TY - JOUR T1 - COPD中静脉血栓栓塞的发生率:炎症和血栓的联系?JF - European Respiratory Journal JO - Eur Respir J SP - 369 LP - 373 DO - 10.1183/13993003.01679-2015 VL - 47 IS -2 AU - Lankeit, Mareike AU - Held，Matthias Y1 - 2016/02/01 UR - //www.qdcxjkg.com/content/47/2/369.abstract N2 -慢性阻塞性肺病(COPD)是一个主要的健康负担，预计到2030年将成为第三大死亡原因[1,2]。急性加重伴呼吸症状加重与进行性肺功能下降加速和预后显著恶化相关(住院死亡率，10%;3年死亡率49%)[2]。对伴有呼吸困难加重的COPD患者的管理仍然具有挑战性，在大约三分之一的病例中，根本原因无法确定[2]。重要的是，越来越多的证据表明，在有COPD加重症状的相关比例患者中，潜在的病情是肺栓塞的急性发作。在过去10年发表的所有研究中，调查了因COPD加重住院患者的肺栓塞患病率[3 - 12](表1)，这些研究采用前瞻性研究设计，包括肺栓塞检查的标准化方案(表1中粗体突出显示[3,5 - 7，9-11]报告的肺栓塞发生率较高(14.4%(1406例患者中203例);范围3.3 - -29.1%)。 On the other hand, retrospective population data from 58 392 000 patients hospitalised with COPD from 1979 to 2003 registered in the United States National Hospital Discharge Survey suggest that, in patients with COPD, both deep vein thrombosis (632 000 patients (1.08%)) and pulmonary embolism (381 000 patients (0.65%)) are generally underdiagnosed in clinical practice [13]. Furthermore, in a retrospective observational study including 436 consecutive patients with acute pulmonary embolism, COPD was identified as an independent predictor of a delayed diagnosis [14]. Given the therapeutic and prognostic implications of a (missed) diagnosis of acute pulmonary embolism, it appears crucial to increase awareness of this clinical condition [15], identify predictors of pulmonary embolism in patients with COPD exacerbation [11] and incorporate pulmonary embolism into the differential diagnosis work-up of COPD patients presenting with worsening dyspnoea.Impact of systemic inflammation to an increased prevalence and incidence of VTE in COPD patients http://ow.ly/UgU1a ER -