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Overall, it is a well) /Type /StructElem /S /Span >> endobj 186 0 obj << /Pg 8 0 R /P 89 0 R /K [39] /ActualText (-) /Type /StructElem /S /Span >> endobj 187 0 obj << /Pg 8 0 R /P 89 0 R /K [40] /ActualText (designed study; however, we have th) /Type /StructElem /S /Span >> endobj 188 0 obj << /Pg 8 0 R /P 89 0 R /K [41] /ActualText (ree ) /Type /StructElem /S /Span >> endobj 189 0 obj << /Pg 8 0 R /P 89 0 R /K [42] /ActualText (concerns about the findings of this study.) /Type /StructElem /S /Span >> endobj 190 0 obj << /Pg 8 0 R /P 89 0 R /K [43] /ActualText ( ) /Type /StructElem /S /Span >> endobj 90 0 obj << /Pg 8 0 R /P 39 0 R /K [191 0 R 192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R 198 0 R 199 0 R 200 0 R 201 0 R 202 0 R 203 0 R 204 0 R 205 0 R 206 0 R 207 0 R 208 0 R 209 0 R 210 0 R 211 0 R 212 0 R 213 0 R 214 0 R 215 0 R 216 0 R 217 0 R 218 0 R 219 0 R 220 0 R 221 0 R 222 0 R 223 0 R 224 0 R 225 0 R] /Type /StructElem /S /P >> endobj 191 0 obj << /Pg 8 0 R /P 90 0 R /K [44] /ActualText (First, the study group with immunosuppressant exposure had more underlying ) /Type /StructElem /S /Span >> endobj 192 0 obj << /Pg 8 0 R /P 90 0 R /K [45] /ActualText (comorbidity than those without exposure. ) /Type /StructElem /S /Span >> endobj 193 0 obj << /Pg 8 0 R /P 90 0 R /K [46] /ActualText (T) /Type /StructElem /S /Span >> endobj 194 0 obj << /Pg 8 0 R /P 90 0 R /K [47] /ActualText (he results could be due to bias by ) /Type /StructElem /S /Span >> endobj 195 0 obj << /Pg 8 0 R /P 90 0 R /K [48] /ActualText (indication where patients with more severe disease receiv) /Type /StructElem /S /Span >> endobj 196 0 obj << /Pg 8 0 R /P 90 0 R /K [49] /ActualText (e immunosuppressive drugs) /Type /StructElem /S /Span >> endobj 197 0 obj << /Pg 8 0 R /P 90 0 R /K [50] /ActualText (.) /Type /StructElem /S /Span >> endobj 198 0 obj << /Pg 8 0 R /P 90 0 R /K [51] /ActualText ( ) /Type /StructElem /S /Span >> endobj 199 0 obj << /Pg 8 0 R /P 90 0 R /K [52] /ActualText (C) /Type /StructElem /S /Span >> endobj 200 0 obj << /Pg 8 0 R /P 90 0 R /K [53] /ActualText (ompared ) /Type /StructElem /S /Span >> endobj 201 0 obj << /Pg 8 0 R /P 90 0 R /K [54] /ActualText (with the unexposed group, ) /Type /StructElem /S /Span >> endobj 202 0 obj << /Pg 8 0 R /P 90 0 R /K [55] /ActualText (the exposed group ) /Type /StructElem /S /Span >> endobj 203 0 obj << /Pg 8 0 R /P 90 0 R /K [56] /ActualText (were) /Type /StructElem /S /Span >> endobj 204 0 obj << /Pg 8 0 R /P 90 0 R /K [57] /ActualText ( ) /Type /StructElem /S /Span >> endobj 205 0 obj << /Pg 8 0 R /P 90 0 R /K [58] /ActualText (older, and had more ) /Type /StructElem /S /Span >> endobj 206 0 obj << /Pg 8 0 R /P 90 0 R /K [59] /ActualText (neurologic) /Type /StructElem /S /Span >> endobj 207 0 obj << /Pg 8 0 R /P 90 0 R /K [60] /ActualText ( ) /Type /StructElem /S /Span >> endobj 208 0 obj << /Pg 8 0 R /P 90 0 R /K [61] /ActualText (and musculoskeletal disease, and skin disease \(all standard mean ) /Type /StructElem /S /Span >> endobj 209 0 obj << /Pg 8 0 R /P 90 0 R /K [62] /ActualText (difference > 0.1\)\(table 1\). Therefore, the baseline characteristics of the ) /Type /StructElem /S /Span >> endobj 210 0 obj << /Pg 8 0 R /P 90 0 R /K [63] /ActualText (study and the ) /Type /StructElem /S /Span >> endobj 211 0 obj << /Pg 8 0 R /P 90 0 R /K [64] /ActualText (control group were not perfectly balanced. In addition, because the patients may have ) /Type /StructElem /S /Span >> endobj 212 0 obj << /Pg 8 0 R /P 90 0 R /K [65] /ActualText (multiple comorbidities) /Type /StructElem /S /Span >> endobj 213 0 obj << /Pg 8 0 R /P 90 0 R /K [66] /ActualText ( ) /Type /StructElem /S /Span >> endobj 214 0 obj << /Pg 8 0 R /P 90 0 R /K [67] /ActualText (and more comorbidities would be associated with the worse ) /Type /StructElem /S /Span >> endobj 215 0 obj << /Pg 8 0 R /P 90 0 R /K [68] /ActualText (outcome of patients with COVID) /Type /StructElem /S /Span >> endobj 216 0 obj << /Pg 8 0 R /P 90 0 R /K [69] /ActualText (-) /Type /StructElem /S /Span >> endobj 217 0 obj << /Pg 8 0 R /P 90 0 R /K [70] /ActualText (19) /Type /StructElem /S /Span >> endobj 218 0 obj << /Pg 8 0 R /P 90 0 R /K [71] /ActualText (, we wondered whether the number of ) /Type /StructElem /S /Span >> endobj 219 0 obj << /Pg 8 0 R /P 90 0 R /K [72] /ActualText (comorb) /Type /StructElem /S /Span >> endobj 220 0 obj << /Pg 8 0 R /P 90 0 R /K [73] /ActualText (idities using Charlson comorbidity index were matched or not between these ) /Type /StructElem /S /Span >> endobj 221 0 obj << /Pg 8 0 R /P 90 0 R /K [74] /ActualText (two group) /Type /StructElem /S /Span >> endobj 222 0 obj << /Pg 8 0 R /P 90 0 R /K [75] /ActualText (s) /Type /StructElem /S /Span >> endobj 223 0 obj << /Pg 8 0 R /P 90 0 R /K [76] /ActualText (.) /Type /StructElem /S /Span >> endobj 224 0 obj << /Pg 8 0 R /P 90 0 R /K [77] /ActualText ( ) /Type /StructElem /S /Span >> endobj 225 0 obj << /Pg 8 0 R /P 90 0 R /K [78] /ActualText (Finally, diabetes mellitus \(DM\) is a common underlying disease of ) /Type /StructElem /S /Span >> endobj 91 0 obj << /Pg 9 0 R /P 39 0 R /K [226 0 R 227 0 R 228 0 R 229 0 R 230 0 R 231 0 R 232 0 R 233 0 R 234 0 R 235 0 R 236 0 R 237 0 R 238 0 R 239 0 R 240 0 R 241 0 R 242 0 R 243 0 R 244 0 R 245 0 R 246 0 R 247 0 R] /Type /StructElem /S /P >> endobj 226 0 obj << /Pg 9 0 R /P 91 0 R /K [0] /ActualText (hospital patients with COVID) /Type /StructElem /S /Span >> endobj 44 0 obj [226 0 R 227 0 R 228 0 R 229 0 R 230 0 R 231 0 R 232 0 R 233 0 R 234 0 R 235 0 R 236 0 R 237 0 R 238 0 R 239 0 R 240 0 R 241 0 R 242 0 R 243 0 R 244 0 R 245 0 R 246 0 R 247 0 R 248 0 R 249 0 R 250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R 257 0 R 258 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R 267 0 R 268 0 R 269 0 R 270 0 R 271 0 R 272 0 R 273 0 R 274 0 R 275 0 R 276 0 R 277 0 R 278 0 R 279 0 R 280 0 R 281 0 R 282 0 R 283 0 R 284 0 R 285 0 R 286 0 R 287 0 R 288 0 R 289 0 R 290 0 R 291 0 R 292 0 R 293 0 R 294 0 R 295 0 R 296 0 R 297 0 R 298 0 R 299 0 R 300 0 R 301 0 R 302 0 R 303 0 R 304 0 R 305 0 R 306 0 R 307 0 R 308 0 R 309 0 R 310 0 R 311 0 R 312 0 R 313 0 R 314 0 R 315 0 R] endobj 227 0 obj << /Pg 9 0 R /P 91 0 R /K [1] /ActualText (-) /Type /StructElem /S /Span >> endobj 228 0 obj << /Pg 9 0 R /P 91 0 R /K [2] /ActualText (19 and can be associated with severe COVID) /Type /StructElem /S /Span >> endobj 229 0 obj << /Pg 9 0 R /P 91 0 R /K [3] /ActualText (-) /Type /StructElem /S /Span >> endobj 230 0 obj << /Pg 9 0 R /P 91 0 R /K [4] /ActualText (19, ) /Type /StructElem /S /Span >> endobj 231 0 obj << /Pg 9 0 R /P 91 0 R /K [5] /ActualText (increased ARDS rate, mortal) /Type /StructElem /S /Span >> endobj 232 0 obj << /Pg 9 0 R /P 91 0 R /K [6] /ActualText (ity, and need for mechanical ventilation ) /Type /StructElem /S /Span >> endobj 233 0 obj << /Pg 9 0 R /P 91 0 R /K [7] /ActualText ([2]) /Type /StructElem /S /Span >> endobj 234 0 obj << /Pg 9 0 R /P 91 0 R /K [8] /ActualText (. Although the ) /Type /StructElem /S /Span >> endobj 235 0 obj << /Pg 9 0 R /P 91 0 R /K [9] /ActualText (authors de) /Type /StructElem /S /Span >> endobj 236 0 obj << /Pg 9 0 R /P 91 0 R /K [10] /ActualText (scribed the use of diabetes drug, they did not show the prevalence of DM ) /Type /StructElem /S /Span >> endobj 237 0 obj << /Pg 9 0 R /P 91 0 R /K [11] /ActualText (among the study subjects. Because all the above could ) /Type /StructElem /S /Span >> endobj 238 0 obj << /Pg 9 0 R /P 91 0 R /K [12] /ActualText (affect the outcome of ) /Type /StructElem /S /Span >> endobj 239 0 obj << /Pg 9 0 R /P 91 0 R /K [13] /ActualText (COVID) /Type /StructElem /S /Span >> endobj 240 0 obj << /Pg 9 0 R /P 91 0 R /K [14] /ActualText (-) /Type /StructElem /S /Span >> endobj 241 0 obj << /Pg 9 0 R /P 91 0 R /K [15] /ActualText (19) /Type /StructElem /S /Span >> endobj 242 0 obj << /Pg 9 0 R /P 91 0 R /K [16] /ActualText (, further analysis) /Type /StructElem /S /Span >> endobj 243 0 obj << /Pg 9 0 R /P 91 0 R /K [17] /ActualText ( ) /Type /StructElem /S /Span >> endobj 244 0 obj << /Pg 9 0 R /P 91 0 R /K [18] /ActualText (to clarify these issues) /Type /StructElem /S /Span >> endobj 245 0 obj << /Pg 9 0 R /P 91 0 R /K [19] /ActualText ( ) /Type /StructElem /S /Span >> endobj 246 0 obj << /Pg 9 0 R /P 91 0 R /K [20] /ActualText (is warranted.) /Type /StructElem /S /Span >> endobj 247 0 obj << /Pg 9 0 R /P 91 0 R /K [21] /ActualText ( ) /Type /StructElem /S /Span >> endobj 92 0 obj << /Pg 9 0 R /P 39 0 R /K [248 0 R 249 0 R 250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R 257 0 R 258 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R 267 0 R 268 0 R 269 0 R 270 0 R 271 0 R 272 0 R 273 0 R 274 0 R 275 0 R 276 0 R 277 0 R 278 0 R 279 0 R 280 0 R 281 0 R 282 0 R 283 0 R 284 0 R 285 0 R 286 0 R 287 0 R 288 0 R 289 0 R 290 0 R 291 0 R 292 0 R 293 0 R 294 0 R 295 0 R 296 0 R 297 0 R 298 0 R 299 0 R 300 0 R 301 0 R 302 0 R 303 0 R 304 0 R 305 0 R 306 0 R 307 0 R] /Type /StructElem /S /P >> endobj 248 0 obj << /Pg 9 0 R /P 92 0 R /K [22] /ActualText (Second, although chronic obstructive ) /Type /StructElem /S /Span >> endobj 249 0 obj << /Pg 9 0 R /P 92 0 R /K [23] /ActualText (pulmonary disease \(COPD\) and asthma) /Type /StructElem /S /Span >> endobj 250 0 obj << /Pg 9 0 R /P 92 0 R /K [24] /ActualText (, which ) /Type /StructElem /S /Span >> endobj 251 0 obj << /Pg 9 0 R /P 92 0 R /K [25] /ActualText (were supposed to be classified as pulmonary disease in this study, the impact) /Type /StructElem /S /Span >> endobj 252 0 obj << /Pg 9 0 R /P 92 0 R /K [26] /ActualText (s) /Type /StructElem /S /Span >> endobj 253 0 obj << /Pg 9 0 R /P 92 0 R /K [27] /ActualText ( ) /Type /StructElem /S /Span >> endobj 254 0 obj << /Pg 9 0 R /P 92 0 R /K [28] /ActualText (of ) /Type /StructElem /S /Span >> endobj 255 0 obj << /Pg 9 0 R /P 92 0 R /K [29] /ActualText (COPD and asthma on COVID) /Type /StructElem /S /Span >> endobj 256 0 obj << /Pg 9 0 R /P 92 0 R /K [30] /ActualText (-) /Type /StructElem /S /Span >> endobj 257 0 obj << /Pg 9 0 R /P 92 0 R /K [31] /ActualText (19 w) /Type /StructElem /S /Span >> endobj 258 0 obj << /Pg 9 0 R /P 92 0 R /K [32] /ActualText (ere) /Type /StructElem /S /Span >> endobj 259 0 obj << /Pg 9 0 R /P 92 0 R /K [33] /ActualText ( ) /Type /StructElem /S /Span >> endobj 260 0 obj << /Pg 9 0 R /P 92 0 R /K [34] /ActualText (different) /Type /StructElem /S /Span >> endobj 261 0 obj << /Pg 9 0 R /P 92 0 R /K [35] /ActualText ( ) /Type /StructElem /S /Span >> endobj 262 0 obj << /Pg 9 0 R /P 92 0 R /K [36] /ActualText ([3, 4]) /Type /StructElem /S /Span >> endobj 263 0 obj << /Pg 9 0 R /P 92 0 R /K [37] /ActualText (. ) /Type /StructElem /S /Span >> endobj 264 0 obj << /Pg 9 0 R /P 92 0 R /K [38] /ActualText (For patients with asthma, a ) /Type /StructElem /S /Span >> endobj 265 0 obj << /Pg 9 0 R /P 92 0 R /K [39] /ActualText (meta) /Type /StructElem /S /Span >> endobj 266 0 obj << /Pg 9 0 R /P 92 0 R /K [40] /ActualText (-) /Type /StructElem /S /Span >> endobj 267 0 obj << /Pg 9 0 R /P 92 0 R /K [41] /ActualText (analysis of 51 studies showed the risk ratios for COVID) /Type /StructElem /S /Span >> endobj 268 0 obj << /Pg 9 0 R /P 92 0 R /K [42] /ActualText (-) /Type /StructElem /S /Span >> endobj 269 0 obj << /Pg 9 0 R /P 92 0 R /K [43] /ActualText (19 associated ) /Type /StructElem /S /Span >> endobj 270 0 obj << /Pg 9 0 R /P 92 0 R /K [44] /ActualText (hospitalization, intensive care unit admission, ventilator use and mortality were 1.18 ) /Type /StructElem /S /Span >> endobj 271 0 obj << /Pg 9 0 R /P 92 0 R /K [45] /ActualText (\(95% CI 0.98) /Type /StructElem /S /Span >> endobj 272 0 obj << /Pg 9 0 R /P 92 0 R /K [46] /ActualText (-) /Type /StructElem /S /Span >> endobj 273 0 obj << /Pg 9 0 R /P 92 0 R /K [47] /ActualText (1.42\), 1.21 \(95% CI 0.97) /Type /StructElem /S /Span >> endobj 274 0 obj << /Pg 9 0 R /P 92 0 R /K [48] /ActualText (-) /Type /StructElem /S /Span >> endobj 275 0 obj << /Pg 9 0 R /P 92 0 R /K [49] /ActualText (1.51, p=0.09\), 1.06 \() /Type /StructElem /S /Span >> endobj 276 0 obj << /Pg 9 0 R /P 92 0 R /K [50] /ActualText (95% CI 0.82) /Type /StructElem /S /Span >> endobj 277 0 obj << /Pg 9 0 R /P 92 0 R /K [51] /ActualText (-) /Type /StructElem /S /Span >> endobj 278 0 obj << /Pg 9 0 R /P 92 0 R /K [52] /ActualText (1.36, ) /Type /StructElem /S /Span >> endobj 279 0 obj << /Pg 9 0 R /P 92 0 R /K [53] /ActualText (p=0.65\) and 0.94 \(95% CI 0.76) /Type /StructElem /S /Span >> endobj 280 0 obj << /Pg 9 0 R /P 92 0 R /K [54] /ActualText (-) /Type /StructElem /S /Span >> endobj 281 0 obj << /Pg 9 0 R /P 92 0 R /K [55] /ActualText (1.17, p=0.58\) and suggest that asthma was not ) /Type /StructElem /S /Span >> endobj 282 0 obj << /Pg 9 0 R /P 92 0 R /K [56] /ActualText (associated with adverse outcome of COVID) /Type /StructElem /S /Span >> endobj 283 0 obj << /Pg 9 0 R /P 92 0 R /K [57] /ActualText (-) /Type /StructElem /S /Span >> endobj 284 0 obj << /Pg 9 0 R /P 92 0 R /K [58] /ActualText (19 ) /Type /StructElem /S /Span >> endobj 285 0 obj << /Pg 9 0 R /P 92 0 R /K [59] /ActualText ([4]) /Type /StructElem /S /Span >> endobj 286 0 obj << /Pg 9 0 R /P 92 0 R /K [60] /ActualText (. ) /Type /StructElem /S /Span >> endobj 287 0 obj << /Pg 9 0 R /P 92 0 R /K [61] /ActualText (In contrast, a) /Type /StructElem /S /Span >> endobj 288 0 obj << /Pg 9 0 R /P 92 0 R /K [62] /ActualText (nother meta) /Type /StructElem /S /Span >> endobj 289 0 obj << /Pg 9 0 R /P 92 0 R /K [63] /ActualText (-) /Type /StructElem /S /Span >> endobj 290 0 obj << /Pg 9 0 R /P 92 0 R /K [64] /ActualText (analysis ) /Type /StructElem /S /Span >> endobj 291 0 obj << /Pg 9 0 R /P 92 0 R /K [65] /ActualText (of 59 studies demonstrated that COPD could be associated with increased odds of ) /Type /StructElem /S /Span >> endobj 292 0 obj << /Pg 9 0 R /P 92 0 R /K [66] /ActualText (hospitalization \(odds ratio [OR], 4.23; 95% CI, 3.65) /Type /StructElem /S /Span >> endobj 293 0 obj << /Pg 9 0 R /P 92 0 R /K [67] /ActualText (-) /Type /StructElem /S /Span >> endobj 294 0 obj << /Pg 9 0 R /P 92 0 R /K [68] /ActualText (4.90\), ICU admission \(OR, 1.35; ) /Type /StructElem /S /Span >> endobj 295 0 obj << /Pg 9 0 R /P 92 0 R /K [69] /ActualText (95% CI, 1.02) /Type /StructElem /S /Span >> endobj 296 0 obj << /Pg 9 0 R /P 92 0 R /K [70] /ActualText (-) /Type /StructElem /S /Span >> endobj 297 0 obj << /Pg 9 0 R /P 92 0 R /K [71] /ActualText (1.78\), and mortality \(OR, 2.47; 95% CI, 2.18) /Type /StructElem /S /Span >> endobj 298 0 obj << /Pg 9 0 R /P 92 0 R /K [72] /ActualText (-) /Type /StructElem /S /Span >> endobj 299 0 obj << /Pg 9 0 R /P 92 0 R /K [73] /ActualText (2.79\) ) /Type /StructElem /S /Span >> endobj 300 0 obj << /Pg 9 0 R /P 92 0 R /K [74] /ActualText ([3]) /Type /StructElem /S /Span >> endobj 301 0 obj << /Pg 9 0 R /P 92 0 R /K [75] /ActualText (. Therefore, ) /Type /StructElem /S /Span >> endobj 302 0 obj << /Pg 9 0 R /P 92 0 R /K [76] /ActualText (we ) /Type /StructElem /S /Span >> endobj 303 0 obj << /Pg 9 0 R /P 92 0 R /K [77] /ActualText (think using a single term ) /Type /StructElem /S /Span >> endobj 304 0 obj << /Pg 9 0 R /P 92 0 R /K [78] /ActualText ( ) /Type /StructElem /S /Span >> endobj 305 0 obj << /Pg 9 0 R /P 92 0 R /K [79] /ActualText ( ) /Type /StructElem /S /Span >> endobj 306 0 obj << /Pg 9 0 R /P 92 0 R /K [80] /ActualText (pulmonary disease cannot fit all.) /Type /StructElem /S /Span >> endobj 307 0 obj << /Pg 9 0 R /P 92 0 R /K [81] /ActualText ( ) /Type /StructElem /S /Span >> endobj 93 0 obj << /Pg 9 0 R /P 39 0 R /K [308 0 R 309 0 R 310 0 R 311 0 R 312 0 R 313 0 R 314 0 R 315 0 R] /Type /StructElem /S /P >> endobj 308 0 obj << /Pg 9 0 R /P 93 0 R /K [82] /ActualText (Third, many anti) /Type /StructElem /S /Span >> endobj 309 0 obj << /Pg 9 0 R /P 93 0 R /K [83] /ActualText (-) /Type /StructElem /S /Span >> endobj 310 0 obj << /Pg 9 0 R /P 93 0 R /K [84] /ActualText (COVID) /Type /StructElem /S /Span >> endobj 311 0 obj << /Pg 9 0 R /P 93 0 R /K [85] /ActualText (-) /Type /StructElem /S /Span >> endobj 312 0 obj << /Pg 9 0 R /P 93 0 R /K [86] /ActualText (19 medications, such as remdesivir, JAK inhibitor, ) /Type /StructElem /S /Span >> endobj 313 0 obj << /Pg 9 0 R /P 93 0 R /K [87] /ActualText (corticosteroid and interleukin) /Type /StructElem /S /Span >> endobj 314 0 obj << /Pg 9 0 R /P 93 0 R /K [88] /ActualText (-) /Type /StructElem /S /Span >> endobj 315 0 obj << /Pg 9 0 R /P 93 0 R /K [89] /ActualText (6 blockade could help improve the clinical outcomes of ) /Type /StructElem /S /Span >> endobj 94 0 obj << /Pg 10 0 R /P 39 0 R /K [316 0 R 317 0 R 318 0 R 319 0 R 320 0 R 321 0 R 322 0 R 323 0 R 324 0 R 325 0 R] /Type /StructElem /S /P >> endobj 316 0 obj << /Pg 10 0 R /P 94 0 R /K [0] /ActualText (patients with COVID) /Type /StructElem /S /Span >> endobj 45 0 obj [316 0 R 317 0 R 318 0 R 319 0 R 320 0 R 321 0 R 322 0 R 323 0 R 324 0 R 325 0 R 326 0 R 327 0 R 328 0 R 329 0 R 330 0 R 331 0 R 332 0 R 333 0 R 334 0 R 335 0 R 336 0 R 337 0 R 338 0 R 339 0 R 340 0 R 341 0 R] endobj 317 0 obj << /Pg 10 0 R /P 94 0 R /K [1] /ActualText (-) /Type /StructElem /S /Span >> endobj 318 0 obj << /Pg 10 0 R /P 94 0 R /K [2] /ActualText (19 ) /Type /StructElem /S /Span >> endobj 319 0 obj << /Pg 10 0 R /P 94 0 R /K [3] /ActualText ([5) /Type /StructElem /S /Span >> endobj 320 0 obj << /Pg 10 0 R /P 94 0 R /K [4] /ActualText (-) /Type /StructElem /S /Span >> endobj 321 0 obj << /Pg 10 0 R /P 94 0 R /K [5] /ActualText (8]) /Type /StructElem /S /Span >> endobj 322 0 obj << /Pg 10 0 R /P 94 0 R /K [6] /ActualText (, however, none of these important agents were ) /Type /StructElem /S /Span >> endobj 323 0 obj << /Pg 10 0 R /P 94 0 R /K [7] /ActualText (mentioned in the prese) /Type /StructElem /S /Span >> endobj 324 0 obj << /Pg 10 0 R /P 94 0 R /K [8] /ActualText (nt study. ) /Type /StructElem /S /Span >> endobj 325 0 obj << /Pg 10 0 R /P 94 0 R /K [9] /ActualText ( ) /Type /StructElem /S /Span >> endobj 95 0 obj << /Pg 10 0 R /P 39 0 R /K [326 0 R 327 0 R 328 0 R 329 0 R 330 0 R] /Type /StructElem /S /P >> endobj 326 0 obj << /Pg 10 0 R /P 95 0 R /K [10] /ActualText (Although we raised some concerns regarding the study reported by Ward et al.) /Type /StructElem /S /Span >> endobj 327 0 obj << /Pg 10 0 R /P 95 0 R /K [11] /ActualText ([1]) /Type /StructElem /S /Span >> endobj 328 0 obj << /Pg 10 0 R /P 95 0 R /K [12] /ActualText (, this ) /Type /StructElem /S /Span >> endobj 329 0 obj << /Pg 10 0 R /P 95 0 R /K [13] /ActualText (study still provided useful information. ) /Type /StructElem /S /Span >> endobj 330 0 obj << /Pg 10 0 R /P 95 0 R /K [14] /ActualText ( ) /Type /StructElem /S /Span >> endobj 96 0 obj << /Pg 10 0 R /P 39 0 R /K [331 0 R 332 0 R 333 0 R 334 0 R 335 0 R 336 0 R 337 0 R 338 0 R 339 0 R 340 0 R 341 0 R] /Type /StructElem /S /P >> endobj 331 0 obj << /Pg 10 0 R /P 96 0 R /K [15] /ActualText (Conflict of interest: C) /Type /StructElem /S /Span >> endobj 332 0 obj << /Pg 10 0 R /P 96 0 R /K [16] /ActualText (-) /Type /StructElem /S /Span >> endobj 333 0 obj << /Pg 10 0 R /P 96 0 R /K [17] /ActualText (K) /Type /StructElem /S /Span >> endobj 334 0 obj << /Pg 10 0 R /P 96 0 R /K [18] /ActualText (. ) /Type /StructElem /S /Span >> endobj 335 0 obj << /Pg 10 0 R /P 96 0 R /K [19] /ActualText (Hsu) /Type /StructElem /S /Span >> endobj 336 0 obj << /Pg 10 0 R /P 96 0 R /K [20] /ActualText ( ) /Type /StructElem /S /Span >> endobj 337 0 obj << /Pg 10 0 R /P 96 0 R /K [21] /ActualText (has nothing to disclose. C) /Type /StructElem /S /Span >> endobj 338 0 obj << /Pg 10 0 R /P 96 0 R /K [22] /ActualText (-) /Type /StructElem /S /Span >> endobj 339 0 obj << /Pg 10 0 R /P 96 0 R /K [23] /ActualText (C. Lai has nothing to ) /Type /StructElem /S /Span >> endobj 340 0 obj << /Pg 10 0 R /P 96 0 R /K [24] /ActualText (disclose.) /Type /StructElem /S /Span >> endobj 341 0 obj << /Pg 10 0 R /P 96 0 R /K [25] /ActualText ( ) /Type /StructElem /S /Span >> endobj 97 0 obj << /Pg 11 0 R /P 39 0 R /K [342 0 R 343 0 R] /Type /StructElem /S /P >> endobj 342 0 obj << /Pg 11 0 R /P 97 0 R /K [0] /ActualText (References) /Type /StructElem /S /Span >> endobj 46 0 obj [342 0 R 343 0 R 344 0 R 345 0 R 346 0 R 347 0 R 348 0 R 349 0 R 350 0 R 351 0 R 352 0 R 353 0 R 354 0 R 355 0 R 356 0 R 357 0 R 358 0 R 359 0 R 360 0 R 361 0 R 362 0 R 363 0 R 364 0 R 365 0 R 366 0 R 367 0 R 368 0 R 369 0 R 370 0 R 371 0 R 372 0 R 373 0 R 374 0 R 375 0 R 376 0 R 377 0 R 378 0 R 379 0 R 380 0 R 381 0 R 382 0 R 383 0 R 384 0 R 385 0 R 386 0 R 387 0 R 388 0 R 389 0 R 390 0 R 391 0 R 392 0 R 393 0 R 394 0 R 395 0 R 396 0 R 397 0 R 398 0 R 399 0 R 400 0 R 401 0 R 402 0 R 403 0 R 404 0 R 405 0 R 406 0 R 407 0 R 408 0 R 409 0 R 410 0 R 411 0 R 412 0 R 413 0 R 414 0 R 415 0 R 416 0 R 417 0 R 418 0 R 419 0 R 420 0 R 421 0 R 422 0 R 423 0 R 424 0 R 425 0 R 426 0 R 427 0 R 428 0 R 429 0 R 430 0 R 431 0 R 432 0 R 433 0 R 434 0 R 435 0 R 436 0 R 437 0 R 438 0 R 439 0 R 440 0 R 441 0 R 442 0 R 443 0 R 444 0 R 445 0 R 446 0 R 447 0 R 448 0 R 449 0 R 450 0 R 451 0 R 452 0 R 453 0 R 454 0 R 455 0 R] endobj 343 0 obj << /Pg 11 0 R /P 97 0 R /K [1] /ActualText ( ) /Type /StructElem /S /Span >> endobj 98 0 obj << /Pg 11 0 R /P 39 0 R /K [344 0 R 345 0 R 346 0 R 347 0 R 348 0 R 349 0 R 350 0 R 351 0 R 352 0 R 353 0 R 354 0 R] /Type /StructElem /S /P >> endobj 344 0 obj << /Pg 11 0 R /P 98 0 R /K [2] /ActualText (1.) /Type /StructElem /S /Span >> endobj 345 0 obj << /Pg 11 0 R /P 98 0 R /K [3] /ActualText ( ) /Type /StructElem /S /Span >> endobj 346 0 obj << /Pg 11 0 R /P 98 0 R /K [4] /ActualText (Ward D, Grtz S, Ernst MT, et al. The effect of immunosuppressants on the ) /Type /StructElem /S /Span >> endobj 347 0 obj << /Pg 11 0 R /P 98 0 R /K [5] /ActualText (prognosis of SARS) /Type /StructElem /S /Span >> endobj 348 0 obj << /Pg 11 0 R /P 98 0 R /K [6] /ActualText (-) /Type /StructElem /S /Span >> endobj 349 0 obj << /Pg 11 0 R /P 98 0 R /K [7] /ActualText (CoV) /Type /StructElem /S /Span >> endobj 350 0 obj << /Pg 11 0 R /P 98 0 R /K [8] /ActualText (-) /Type /StructElem /S /Span >> endobj 351 0 obj << /Pg 11 0 R /P 98 0 R /K [9] /ActualText (2 infection. Eur Respir J ) /Type /StructElem /S /Span >> endobj 352 0 obj << /Pg 11 0 R /P 98 0 R /K [10] /ActualText (2021) /Type /StructElem /S /Span >> endobj 353 0 obj << /Pg 11 0 R /P 98 0 R /K [11] /ActualText (; 59\(4\).) /Type /StructElem /S /Span >> endobj 354 0 obj << /Pg 11 0 R /P 98 0 R /K [12] /ActualText ( ) /Type /StructElem /S /Span >> endobj 99 0 obj << /Pg 11 0 R /P 39 0 R /K [355 0 R 356 0 R 357 0 R 358 0 R 359 0 R 360 0 R 361 0 R 362 0 R 363 0 R 364 0 R 365 0 R 366 0 R 367 0 R 368 0 R 369 0 R] /Type /StructElem /S /P >> endobj 355 0 obj << /Pg 11 0 R /P 99 0 R /K [13] /ActualText (2.) /Type /StructElem /S /Span >> endobj 356 0 obj << /Pg 11 0 R /P 99 0 R /K [14] /ActualText ( ) /Type /StructElem /S /Span >> endobj 357 0 obj << /Pg 11 0 R /P 99 0 R /K [15] /ActualText (Bradley SA, Banach M, Alvarado N, Smokovski I, Bhaskar SMM. Prevalence ) /Type /StructElem /S /Span >> endobj 358 0 obj << /Pg 11 0 R /P 99 0 R /K [16] /ActualText (and impact of diabetes in ) /Type /StructElem /S /Span >> endobj 359 0 obj << /Pg 11 0 R /P 99 0 R /K [17] /ActualText (hospitalized COVID) /Type /StructElem /S /Span >> endobj 360 0 obj << /Pg 11 0 R /P 99 0 R /K [18] /ActualText (-) /Type /StructElem /S /Span >> endobj 361 0 obj << /Pg 11 0 R /P 99 0 R /K [19] /ActualText (19 patients: A systematic review ) /Type /StructElem /S /Span >> endobj 362 0 obj << /Pg 11 0 R /P 99 0 R /K [20] /ActualText (and meta) /Type /StructElem /S /Span >> endobj 363 0 obj << /Pg 11 0 R /P 99 0 R /K [21] /ActualText (-) /Type /StructElem /S /Span >> endobj 364 0 obj << /Pg 11 0 R /P 99 0 R /K [22] /ActualText (analysis. J Diabetes ) /Type /StructElem /S /Span >> endobj 365 0 obj << /Pg 11 0 R /P 99 0 R /K [23] /ActualText (2022) /Type /StructElem /S /Span >> endobj 366 0 obj << /Pg 11 0 R /P 99 0 R /K [24] /ActualText (; 14\(2\): 144) /Type /StructElem /S /Span >> endobj 367 0 obj << /Pg 11 0 R /P 99 0 R /K [25] /ActualText (-) /Type /StructElem /S /Span >> endobj 368 0 obj << /Pg 11 0 R /P 99 0 R /K [26] /ActualText (57.) /Type /StructElem /S /Span >> endobj 369 0 obj << /Pg 11 0 R /P 99 0 R /K [27] /ActualText ( ) /Type /StructElem /S /Span >> endobj 100 0 obj << /Pg 11 0 R /P 39 0 R /K [370 0 R 371 0 R 372 0 R 373 0 R 374 0 R 375 0 R 376 0 R 377 0 R 378 0 R 379 0 R 380 0 R 381 0 R 382 0 R] /Type /StructElem /S /P >> endobj 370 0 obj << /Pg 11 0 R /P 100 0 R /K [28] /ActualText (3.) /Type /StructElem /S /Span >> endobj 371 0 obj << /Pg 11 0 R /P 100 0 R /K [29] /ActualText ( ) /Type /StructElem /S /Span >> endobj 372 0 obj << /Pg 11 0 R /P 100 0 R /K [30] /ActualText (Gerayeli FV, Milne S, Cheung C, et al. COPD and the risk of poor outcomes in ) /Type /StructElem /S /Span >> endobj 373 0 obj << /Pg 11 0 R /P 100 0 R /K [31] /ActualText (COVID) /Type /StructElem /S /Span >> endobj 374 0 obj << /Pg 11 0 R /P 100 0 R /K [32] /ActualText (-) /Type /StructElem /S /Span >> endobj 375 0 obj << /Pg 11 0 R /P 100 0 R /K [33] /ActualText (19: A systematic review and meta) /Type /StructElem /S /Span >> endobj 376 0 obj << /Pg 11 0 R /P 100 0 R /K [34] /ActualText (-) /Type /StructElem /S /Span >> endobj 377 0 obj << /Pg 11 0 R /P 100 0 R /K [35] /ActualText (analysis. EClinicalMedicine ) /Type /StructElem /S /Span >> endobj 378 0 obj << /Pg 11 0 R /P 100 0 R /K [36] /ActualText (2021) /Type /StructElem /S /Span >> endobj 379 0 obj << /Pg 11 0 R /P 100 0 R /K [37] /ActualText (; ) /Type /StructElem /S /Span >> endobj 380 0 obj << /Pg 11 0 R /P 100 0 R /K [38] /ActualText (33: ) /Type /StructElem /S /Span >> endobj 381 0 obj << /Pg 11 0 R /P 100 0 R /K [39] /ActualText (100789.) /Type /StructElem /S /Span >> endobj 382 0 obj << /Pg 11 0 R /P 100 0 R /K [40] /ActualText ( ) /Type /StructElem /S /Span >> endobj 101 0 obj << /Pg 11 0 R /P 39 0 R /K [383 0 R 384 0 R 385 0 R 386 0 R 387 0 R 388 0 R 389 0 R 390 0 R 391 0 R 392 0 R 393 0 R] /Type /StructElem /S /P >> endobj 383 0 obj << /Pg 11 0 R /P 101 0 R /K [41] /ActualText (4.) /Type /StructElem /S /Span >> endobj 384 0 obj << /Pg 11 0 R /P 101 0 R /K [42] /ActualText ( ) /Type /StructElem /S /Span >> endobj 385 0 obj << /Pg 11 0 R /P 101 0 R /K [43] /ActualText (Sunjaya AP, Allida SM, Di Tanna GL, Jenkins CR. Asthma and COVID) /Type /StructElem /S /Span >> endobj 386 0 obj << /Pg 11 0 R /P 101 0 R /K [44] /ActualText (-) /Type /StructElem /S /Span >> endobj 387 0 obj << /Pg 11 0 R /P 101 0 R /K [45] /ActualText (19 risk: a ) /Type /StructElem /S /Span >> endobj 388 0 obj << /Pg 11 0 R /P 101 0 R /K [46] /ActualText (systematic review and meta) /Type /StructElem /S /Span >> endobj 389 0 obj << /Pg 11 0 R /P 101 0 R /K [47] /ActualText (-) /Type /StructElem /S /Span >> endobj 390 0 obj << /Pg 11 0 R /P 101 0 R /K [48] /ActualText (analysis. Eur Respir J ) /Type /StructElem /S /Span >> endobj 391 0 obj << /Pg 11 0 R /P 101 0 R /K [49] /ActualText (2022) /Type /StructElem /S /Span >> endobj 392 0 obj << /Pg 11 0 R /P 101 0 R /K [50] /ActualText (; 59\(3\).) /Type /StructElem /S /Span >> endobj 393 0 obj << /Pg 11 0 R /P 101 0 R /K [51] /ActualText ( ) /Type /StructElem /S /Span >> endobj 102 0 obj << /Pg 11 0 R /P 39 0 R /K [394 0 R 395 0 R 396 0 R 397 0 R 398 0 R 399 0 R 400 0 R 401 0 R 402 0 R 403 0 R 404 0 R 405 0 R 406 0 R 407 0 R 408 0 R 409 0 R 410 0 R 411 0 R 412 0 R] /Type /StructElem /S /P >> endobj 394 0 obj << /Pg 11 0 R /P 102 0 R /K [52] /ActualText (5.) /Type /StructElem /S /Span >> endobj 395 0 obj << /Pg 11 0 R /P 102 0 R /K [53] /ActualText ( ) /Type /StructElem /S /Span >> endobj 396 0 obj << /Pg 11 0 R /P 102 0 R /K [54] /ActualText (Shankar) /Type /StructElem /S /Span >> endobj 397 0 obj << /Pg 11 0 R /P 102 0 R /K [55] /ActualText (-) /Type /StructElem /S /Span >> endobj 398 0 obj << /Pg 11 0 R /P 102 0 R /K [56] /ActualText (Hari M, Vale CL, Godolphin PJ, et al. Association Between ) /Type /StructElem /S /Span >> endobj 399 0 obj << /Pg 11 0 R /P 102 0 R /K [57] /ActualText (Administration of IL) /Type /StructElem /S /Span >> endobj 400 0 obj << /Pg 11 0 R /P 102 0 R /K [58] /ActualText (-) /Type /StructElem /S /Span >> endobj 401 0 obj << /Pg 11 0 R /P 102 0 R /K [59] /ActualText (6 Antagonist) /Type /StructElem /S /Span >> endobj 402 0 obj << /Pg 11 0 R /P 102 0 R /K [60] /ActualText (s and Mortality Among Patients Hospitalized ) /Type /StructElem /S /Span >> endobj 403 0 obj << /Pg 11 0 R /P 102 0 R /K [61] /ActualText (for COVID) /Type /StructElem /S /Span >> endobj 404 0 obj << /Pg 11 0 R /P 102 0 R /K [62] /ActualText (-) /Type /StructElem /S /Span >> endobj 405 0 obj << /Pg 11 0 R /P 102 0 R /K [63] /ActualText (19: A Meta) /Type /StructElem /S /Span >> endobj 406 0 obj << /Pg 11 0 R /P 102 0 R /K [64] /ActualText (-) /Type /StructElem /S /Span >> endobj 407 0 obj << /Pg 11 0 R /P 102 0 R /K [65] /ActualText (analysis. Jama ) /Type /StructElem /S /Span >> endobj 408 0 obj << /Pg 11 0 R /P 102 0 R /K [66] /ActualText (2021) /Type /StructElem /S /Span >> endobj 409 0 obj << /Pg 11 0 R /P 102 0 R /K [67] /ActualText (; 326\(6\): 499) /Type /StructElem /S /Span >> endobj 410 0 obj << /Pg 11 0 R /P 102 0 R /K [68] /ActualText (-) /Type /StructElem /S /Span >> endobj 411 0 obj << /Pg 11 0 R /P 102 0 R /K [69] /ActualText (518.) /Type /StructElem /S /Span >> endobj 412 0 obj << /Pg 11 0 R /P 102 0 R /K [70] /ActualText ( ) /Type /StructElem /S /Span >> endobj 103 0 obj << /Pg 11 0 R /P 39 0 R /K [413 0 R 414 0 R 415 0 R 416 0 R 417 0 R 418 0 R 419 0 R 420 0 R 421 0 R 422 0 R 423 0 R 424 0 R 425 0 R 426 0 R] /Type /StructElem /S /P >> endobj 413 0 obj << /Pg 11 0 R /P 103 0 R /K [71] /ActualText (6.) /Type /StructElem /S /Span >> endobj 414 0 obj << /Pg 11 0 R /P 103 0 R /K [72] /ActualText ( ) /Type /StructElem /S /Span >> endobj 415 0 obj << /Pg 11 0 R /P 103 0 R /K [73] /ActualText (Sterne JAC, Murthy S, Diaz JV, et al. Association Between Administration of ) /Type /StructElem /S /Span >> endobj 416 0 obj << /Pg 11 0 R /P 103 0 R /K [74] /ActualText (Systemic Corticosteroids and Mortality Among Critically Ill Patients With ) /Type /StructElem /S /Span >> endobj 417 0 obj << /Pg 11 0 R /P 103 0 R /K [75] /ActualText (COVID) /Type /StructElem /S /Span >> endobj 418 0 obj << /Pg 11 0 R /P 103 0 R /K [76] /ActualText (-) /Type /StructElem /S /Span >> endobj 419 0 obj << /Pg 11 0 R /P 103 0 R /K [77] /ActualText (19: A Meta) /Type /StructElem /S /Span >> endobj 420 0 obj << /Pg 11 0 R /P 103 0 R /K [78] /ActualText (-) /Type /StructElem /S /Span >> endobj 421 0 obj << /Pg 11 0 R /P 103 0 R /K [79] /ActualText (analysis. Jama ) /Type /StructElem /S /Span >> endobj 422 0 obj << /Pg 11 0 R /P 103 0 R /K [80] /ActualText (2020) /Type /StructElem /S /Span >> endobj 423 0 obj << /Pg 11 0 R /P 103 0 R /K [81] /ActualText (; 324\(13\): 1330) /Type /StructElem /S /Span >> endobj 424 0 obj << /Pg 11 0 R /P 103 0 R /K [82] /ActualText (-) /Type /StructElem /S /Span >> endobj 425 0 obj << /Pg 11 0 R /P 103 0 R /K [83] /ActualText (41.) /Type /StructElem /S /Span >> endobj 426 0 obj << /Pg 11 0 R /P 103 0 R /K [84] /ActualText ( ) /Type /StructElem /S /Span >> endobj 104 0 obj << /Pg 11 0 R /P 39 0 R /K [427 0 R 428 0 R 429 0 R 430 0 R 431 0 R 432 0 R 433 0 R 434 0 R 435 0 R 436 0 R 437 0 R 438 0 R] /Type /StructElem /S /P >> endobj 427 0 obj << /Pg 11 0 R /P 104 0 R /K [85] /ActualText (7.) /Type /StructElem /S /Span >> endobj 428 0 obj << /Pg 11 0 R /P 104 0 R /K [86] /ActualText ( ) /Type /StructElem /S /Span >> endobj 429 0 obj << /Pg 11 0 R /P 104 0 R /K [87] /ActualText (Chen CY, Chen WC, Hsu CK, Chao CM, Lai CC. Clinical efficacy and safety of ) /Type /StructElem /S /Span >> endobj 430 0 obj << /Pg 11 0 R /P 104 0 R /K [88] /ActualText (Janus kinase inhibitors for COVID) /Type /StructElem /S /Span >> endobj 431 0 obj << /Pg 11 0 R /P 104 0 R /K [89] /ActualText (-) /Type /StructElem /S /Span >> endobj 432 0 obj << /Pg 11 0 R /P 104 0 R /K [90] /ActualText (19: A systematic review and meta) /Type /StructElem /S /Span >> endobj 433 0 obj << /Pg 11 0 R /P 104 0 R /K [91] /ActualText (-) /Type /StructElem /S /Span >> endobj 434 0 obj << /Pg 11 0 R /P 104 0 R /K [92] /ActualText (analysis ) /Type /StructElem /S /Span >> endobj 435 0 obj << /Pg 11 0 R /P 104 0 R /K [93] /ActualText (of randomized controlled trials. 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