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0 R 370 0 R 371 0 R 372 0 R 373 0 R 374 0 R 375 0 R 376 0 R 377 0 R 378 0 R 379 0 R 380 0 R 381 0 R 382 0 R 383 0 R 384 0 R 385 0 R 386 0 R 387 0 R 388 0 R 389 0 R 390 0 R 391 0 R 392 0 R 393 0 R 394 0 R 395 0 R 396 0 R 397 0 R 398 0 R 399 0 R 400 0 R 401 0 R 402 0 R 403 0 R 404 0 R 405 0 R 406 0 R 407 0 R 408 0 R 409 0 R 410 0 R 411 0 R 412 0 R 413 0 R 414 0 R 415 0 R 416 0 R 417 0 R 418 0 R 419 0 R 420 0 R 421 0 R 422 0 R 423 0 R 424 0 R 425 0 R 426 0 R 427 0 R 428 0 R 429 0 R 430 0 R 431 0 R 432 0 R 433 0 R 434 0 R 435 0 R 436 0 R 437 0 R 438 0 R 439 0 R 440 0 R 441 0 R 442 0 R 443 0 R 444 0 R 445 0 R 446 0 R 447 0 R 448 0 R 449 0 R 450 0 R 451 0 R 452 0 R 453 0 R 454 0 R 455 0 R 456 0 R 457 0 R 458 0 R 459 0 R 460 0 R 461 0 R 462 0 R 463 0 R 464 0 R 465 0 R 466 0 R 467 0 R 468 0 R 469 0 R 470 0 R 471 0 R 472 0 R 473 0 R 474 0 R 475 0 R 476 0 R 477 0 R 478 0 R 479 0 R 480 0 R 481 0 R 482 0 R 483 0 R 484 0 R 485 0 R 486 0 R 487 0 R 488 0 R 489 0 R 490 0 R 491 0 R 492 0 R 493 0 R 494 0 R 495 0 R 496 0 R 497 0 R 498 0 R 499 0 R 500 0 R 501 0 R 502 0 R 503 0 R 504 0 R 505 0 R 506 0 R 507 0 R 508 0 R 509 0 R 510 0 R 511 0 R 512 0 R 513 0 R 514 0 R 515 0 R 516 0 R 517 0 R 518 0 R 519 0 R 520 0 R 521 0 R 522 0 R 523 0 R 524 0 R 525 0 R 526 0 R 527 0 R 528 0 R 529 0 R] endobj 327 0 obj << /Pg 25 0 R /P 167 0 R /K [1] /ActualText ( ) /Type /StructElem /S /Span >> endobj 168 0 obj << /Pg 25 0 R /P 81 0 R /K [328 0 R 329 0 R 330 0 R 331 0 R 332 0 R 333 0 R 334 0 R 335 0 R 336 0 R 337 0 R 338 0 R 87 0 R 340 0 R 88 0 R 342 0 R 343 0 R 344 0 R 345 0 R 346 0 R 347 0 R 348 0 R 349 0 R 350 0 R 351 0 R 352 0 R 353 0 R 354 0 R 355 0 R 356 0 R 357 0 R 358 0 R 359 0 R 360 0 R 361 0 R 362 0 R 363 0 R 364 0 R 89 0 R 366 0 R 90 0 R 368 0 R 369 0 R 370 0 R 371 0 R 372 0 R 373 0 R 374 0 R 375 0 R 376 0 R 377 0 R 378 0 R 379 0 R 380 0 R 381 0 R 382 0 R 383 0 R 384 0 R 385 0 R 386 0 R 387 0 R 388 0 R 389 0 R 390 0 R 391 0 R 392 0 R 393 0 R 394 0 R 395 0 R 396 0 R 397 0 R 398 0 R 399 0 R 400 0 R 401 0 R 91 0 R 403 0 R 404 0 R 405 0 R 406 0 R 407 0 R 408 0 R 409 0 R 410 0 R 411 0 R 412 0 R 413 0 R 414 0 R 415 0 R] /Type /StructElem /S /P >> endobj 328 0 obj << /Pg 25 0 R /P 168 0 R /K [2] /ActualText (The associations between atmospheric ozone pollution and ) /Type /StructElem /S /Span >> endobj 329 0 obj << /Pg 25 0 R /P 168 0 R /K [3] /ActualText (increased risk) /Type /StructElem /S /Span >> endobj 330 0 obj << /Pg 25 0 R /P 168 0 R /K [4] /ActualText (s) /Type /StructElem /S /Span >> endobj 331 0 obj << /Pg 25 0 R /P 168 0 R /K [5] /ActualText ( ) /Type /StructElem /S /Span >> endobj 332 0 obj << /Pg 25 0 R /P 168 0 R /K [6] /ActualText (of ) /Type /StructElem /S /Span >> endobj 333 0 obj << /Pg 25 0 R /P 168 0 R /K [7] /ActualText (respiratory ) /Type /StructElem /S /Span >> endobj 334 0 obj << /Pg 25 0 R /P 168 0 R /K [8] /ActualText (diseases) /Type /StructElem /S /Span >> endobj 335 0 obj << /Pg 25 0 R /P 168 0 R /K [9] /ActualText ( ) /Type /StructElem /S /Span >> endobj 336 0 obj << /Pg 25 0 R /P 168 0 R /K [10] /ActualText (have been well established) /Type /StructElem /S /Span >> endobj 337 0 obj << /Pg 25 0 R /P 168 0 R /K [11] /ActualText ( ) /Type /StructElem /S /Span >> endobj 338 0 obj << /Pg 25 0 R /P 168 0 R /K [12] /ActualText ([) /Type /StructElem /S /Span >> endobj 87 0 obj << /Pg 25 0 R /P 168 0 R /K [530 0 R 339 0 R] /Type /StructElem /S /Link >> endobj 530 0 obj << /Pg 25 0 R /Obj 29 0 R /Type /OBJR >> endobj 339 0 obj << /Pg 25 0 R /P 87 0 R /K [13] /ActualText (1) /Type /StructElem /S /Span >> endobj 340 0 obj << /Pg 25 0 R /P 168 0 R /K [14] /ActualText (, ) /Type /StructElem /S /Span >> endobj 88 0 obj << /Pg 25 0 R /P 168 0 R /K [531 0 R 341 0 R] /Type /StructElem /S /Link >> endobj 531 0 obj << /Pg 25 0 R /Obj 30 0 R /Type /OBJR >> endobj 341 0 obj << /Pg 25 0 R /P 88 0 R /K [15] /ActualText (2) /Type /StructElem /S /Span >> endobj 342 0 obj << /Pg 25 0 R /P 168 0 R /K [16] /ActualText (]) /Type /StructElem /S /Span >> endobj 343 0 obj << /Pg 25 0 R /P 168 0 R /K [17] /ActualText (,) /Type /StructElem /S /Span >> endobj 344 0 obj << /Pg 25 0 R /P 168 0 R /K [18] /ActualText ( ) /Type /StructElem /S /Span >> endobj 345 0 obj << /Pg 25 0 R /P 168 0 R /K [19] /ActualText (but) /Type /StructElem /S /Span >> endobj 346 0 obj << /Pg 25 0 R /P 168 0 R /K [20] /ActualText ( ) /Type /StructElem /S /Span >> endobj 347 0 obj << /Pg 25 0 R /P 168 0 R /K [21] /ActualText (the underlying biological ) /Type /StructElem /S /Span >> endobj 348 0 obj << /Pg 25 0 R /P 168 0 R /K [22] /ActualText (mechanisms are yet fully ascertained) /Type /StructElem /S /Span >> endobj 349 0 obj << /Pg 25 0 R /P 168 0 R /K [23] /ActualText (. ) /Type /StructElem /S /Span >> endobj 350 0 obj << /Pg 25 0 R /P 168 0 R /K [24] /ActualText (L) /Type /StructElem /S /Span >> endobj 351 0 obj << /Pg 25 0 R /P 168 0 R /K [25] /ActualText (ung) /Type /StructElem /S /Span >> endobj 352 0 obj << /Pg 25 0 R /P 168 0 R /K [26] /ActualText ( ) /Type /StructElem /S /Span >> endobj 353 0 obj << /Pg 25 0 R /P 168 0 R /K [27] /ActualText (epithelial ) /Type /StructElem /S /Span >> endobj 354 0 obj << /Pg 25 0 R /P 168 0 R /K [28] /ActualText (cells may be injured by inhaled ) /Type /StructElem /S /Span >> endobj 355 0 obj << /Pg 25 0 R /P 168 0 R /K [29] /ActualText (ozone) /Type /StructElem /S /Span >> endobj 356 0 obj << /Pg 25 0 R /P 168 0 R /K [30] /ActualText (,) /Type /StructElem /S /Span >> endobj 357 0 obj << /Pg 25 0 R /P 168 0 R /K [31] /ActualText ( ) /Type /StructElem /S /Span >> endobj 358 0 obj << /Pg 25 0 R /P 168 0 R /K [32] /ActualText (but the ) /Type /StructElem /S /Span >> endobj 359 0 obj << /Pg 25 0 R /P 168 0 R /K [33] /ActualText (results) /Type /StructElem /S /Span >> endobj 360 0 obj << /Pg 25 0 R /P 168 0 R /K [34] /ActualText ( ) /Type /StructElem /S /Span >> endobj 361 0 obj << /Pg 25 0 R /P 168 0 R /K [35] /ActualText (were ) /Type /StructElem /S /Span >> endobj 362 0 obj << /Pg 25 0 R /P 168 0 R /K [36] /ActualText (not fully c) /Type /StructElem /S /Span >> endobj 363 0 obj << /Pg 25 0 R /P 168 0 R /K [37] /ActualText (onsistent ) /Type /StructElem /S /Span >> endobj 364 0 obj << /Pg 25 0 R /P 168 0 R /K [38] /ActualText ([) /Type /StructElem /S /Span >> endobj 89 0 obj << /Pg 25 0 R /P 168 0 R /K [532 0 R 365 0 R] /Type /StructElem /S /Link >> endobj 532 0 obj << /Pg 25 0 R /Obj 31 0 R /Type /OBJR >> endobj 365 0 obj << /Pg 25 0 R /P 89 0 R /K [39] /ActualText (3) /Type /StructElem /S /Span >> endobj 366 0 obj << /Pg 25 0 R /P 168 0 R /K [40] /ActualText (, ) /Type /StructElem /S /Span >> endobj 90 0 obj << /Pg 25 0 R /P 168 0 R /K [533 0 R 367 0 R] /Type /StructElem /S /Link >> endobj 533 0 obj << /Pg 25 0 R /Obj 32 0 R /Type /OBJR >> endobj 367 0 obj << /Pg 25 0 R /P 90 0 R /K [41] /ActualText (4) /Type /StructElem /S /Span >> endobj 368 0 obj << /Pg 25 0 R /P 168 0 R /K [42] /ActualText (]) /Type /StructElem /S /Span >> endobj 369 0 obj << /Pg 25 0 R /P 168 0 R /K [43] /ActualText (.) /Type /StructElem /S /Span >> endobj 370 0 obj << /Pg 25 0 R /P 168 0 R /K [44] /ActualText ( ) /Type /StructElem /S /Span >> endobj 371 0 obj << /Pg 25 0 R /P 168 0 R /K [45] /ActualText (Furthermore) /Type /StructElem /S /Span >> endobj 372 0 obj << /Pg 25 0 R /P 168 0 R /K [46] /ActualText (, res) /Type /StructElem /S /Span >> endobj 373 0 obj << /Pg 25 0 R /P 168 0 R /K [47] /ActualText (piratory ) /Type /StructElem /S /Span >> endobj 374 0 obj << /Pg 25 0 R /P 168 0 R /K [48] /ActualText (microbiota ) /Type /StructElem /S /Span >> endobj 375 0 obj << /Pg 25 0 R /P 168 0 R /K [49] /ActualText (and metabolic homeostasis ) /Type /StructElem /S /Span >> endobj 376 0 obj << /Pg 25 0 R /P 168 0 R /K [50] /ActualText (w) /Type /StructElem /S /Span >> endobj 377 0 obj << /Pg 25 0 R /P 168 0 R /K [51] /ActualText (ere) /Type /StructElem /S /Span >> endobj 378 0 obj << /Pg 25 0 R /P 168 0 R /K [52] /ActualText ( ) /Type /StructElem /S /Span >> endobj 379 0 obj << /Pg 25 0 R /P 168 0 R /K [53] /ActualText (deemed as ) /Type /StructElem /S /Span >> endobj 380 0 obj << /Pg 25 0 R /P 168 0 R /K [54] /ActualText (key) /Type /StructElem /S /Span >> endobj 381 0 obj << /Pg 25 0 R /P 168 0 R /K [55] /ActualText ( ) /Type /StructElem /S /Span >> endobj 382 0 obj << /Pg 25 0 R /P 168 0 R /K [56] /ActualText (factors in maintaining ) /Type /StructElem /S /Span >> endobj 383 0 obj << /Pg 25 0 R /P 168 0 R /K [57] /ActualText (human respiratory health) /Type /StructElem /S /Span >> endobj 384 0 obj << /Pg 25 0 R /P 168 0 R /K [58] /ActualText (, and) /Type /StructElem /S /Span >> endobj 385 0 obj << /Pg 25 0 R /P 168 0 R /K [59] /ActualText ( ) /Type /StructElem /S /Span >> endobj 386 0 obj << /Pg 25 0 R /P 168 0 R /K [60] /ActualText (any disturbances) /Type /StructElem /S /Span >> endobj 387 0 obj << /Pg 25 0 R /P 168 0 R /K [61] /ActualText ( ) /Type /StructElem /S /Span >> endobj 388 0 obj << /Pg 25 0 R /P 168 0 R /K [62] /ActualText (in ) /Type /StructElem /S /Span >> endobj 389 0 obj << /Pg 25 0 R /P 168 0 R /K [63] /ActualText (this balance) /Type /StructElem /S /Span >> endobj 390 0 obj << /Pg 25 0 R /P 168 0 R /K [64] /ActualText ( ) /Type /StructElem /S /Span >> endobj 391 0 obj << /Pg 25 0 R /P 168 0 R /K [65] /ActualText (ha) /Type /StructElem /S /Span >> endobj 392 0 obj << /Pg 25 0 R /P 168 0 R /K [66] /ActualText (ve) /Type /StructElem /S /Span >> endobj 393 0 obj << /Pg 25 0 R /P 168 0 R /K [67] /ActualText ( ) /Type /StructElem /S /Span >> endobj 394 0 obj << /Pg 25 0 R /P 168 0 R /K [68] /ActualText (the potential to ) /Type /StructElem /S /Span >> endobj 395 0 obj << /Pg 25 0 R /P 168 0 R /K [69] /ActualText (increase) /Type /StructElem /S /Span >> endobj 396 0 obj << /Pg 25 0 R /P 168 0 R /K [70] /ActualText ( ) /Type /StructElem /S /Span >> endobj 397 0 obj << /Pg 25 0 R /P 168 0 R /K [71] /ActualText (the susceptibility ) /Type /StructElem /S /Span >> endobj 398 0 obj << /Pg 25 0 R /P 168 0 R /K [72] /ActualText (to ) /Type /StructElem /S /Span >> endobj 399 0 obj << /Pg 25 0 R /P 168 0 R /K [73] /ActualText (respiratory infectious diseases) /Type /StructElem /S /Span >> endobj 400 0 obj << /Pg 25 0 R /P 168 0 R /K [74] /ActualText ( ) /Type /StructElem /S /Span >> endobj 401 0 obj << /Pg 25 0 R /P 168 0 R /K [75] /ActualText ([) /Type /StructElem /S /Span >> endobj 91 0 obj << /Pg 25 0 R /P 168 0 R /K [534 0 R 402 0 R] /Type /StructElem /S /Link >> endobj 534 0 obj << /Pg 25 0 R /Obj 33 0 R /Type /OBJR >> endobj 402 0 obj << /Pg 25 0 R /P 91 0 R /K [76] /ActualText (5) /Type /StructElem /S /Span >> endobj 403 0 obj << /Pg 25 0 R /P 168 0 R /K [77] /ActualText (]) /Type /StructElem /S /Span >> endobj 404 0 obj << /Pg 25 0 R /P 168 0 R /K [78] /ActualText (. However, ) /Type /StructElem /S /Span >> endobj 405 0 obj << /Pg 25 0 R /P 168 0 R /K [79] /ActualText (few) /Type /StructElem /S /Span >> endobj 406 0 obj << /Pg 25 0 R /P 168 0 R /K [80] /ActualText ( ) /Type /StructElem /S /Span >> endobj 407 0 obj << /Pg 25 0 R /P 168 0 R /K [81] /ActualText (human ) /Type /StructElem /S /Span >> endobj 408 0 obj << /Pg 25 0 R /P 168 0 R /K [82] /ActualText (studies have investigated the potential effects of ozone ) /Type /StructElem /S /Span >> endobj 409 0 obj << /Pg 25 0 R /P 168 0 R /K [83] /ActualText (inhalation ) /Type /StructElem /S /Span >> endobj 410 0 obj << /Pg 25 0 R /P 168 0 R /K [84] /ActualText (on respiratory ) /Type /StructElem /S /Span >> endobj 411 0 obj << /Pg 25 0 R /P 168 0 R /K [85] /ActualText (microbiota) /Type /StructElem /S /Span >> endobj 412 0 obj << /Pg 25 0 R /P 168 0 R /K [86] /ActualText ( ) /Type /StructElem /S /Span >> endobj 413 0 obj << /Pg 25 0 R /P 168 0 R /K [87] /ActualText (and metabolome) /Type /StructElem /S /Span >> endobj 414 0 obj << /Pg 25 0 R /P 168 0 R /K [88] /ActualText (. ) /Type /StructElem /S /Span >> endobj 415 0 obj << /Pg 25 0 R /P 168 0 R /K [89] /ActualText ( ) /Type /StructElem /S /Span >> endobj 169 0 obj << /Pg 25 0 R /P 81 0 R /K [416 0 R 417 0 R 418 0 R 419 0 R 420 0 R 421 0 R 422 0 R 423 0 R 424 0 R 425 0 R 426 0 R 427 0 R 428 0 R 429 0 R 430 0 R 431 0 R 432 0 R 433 0 R 434 0 R 435 0 R 436 0 R 437 0 R 438 0 R 439 0 R 440 0 R 441 0 R 442 0 R 443 0 R 444 0 R 445 0 R 446 0 R 447 0 R 448 0 R 449 0 R 450 0 R 451 0 R 92 0 R 453 0 R 93 0 R 457 0 R 458 0 R 459 0 R 460 0 R 461 0 R 462 0 R 463 0 R 464 0 R 465 0 R 466 0 R 467 0 R 468 0 R 469 0 R 470 0 R 471 0 R 472 0 R 473 0 R 474 0 R 475 0 R 476 0 R 477 0 R 478 0 R 94 0 R 480 0 R 95 0 R 482 0 R 483 0 R 484 0 R 485 0 R 486 0 R 487 0 R 488 0 R 489 0 R 490 0 R 96 0 R 492 0 R 493 0 R 494 0 R 495 0 R 496 0 R 497 0 R 498 0 R 499 0 R 500 0 R 501 0 R 502 0 R 503 0 R 504 0 R 505 0 R 506 0 R 507 0 R 508 0 R 509 0 R 510 0 R 511 0 R 512 0 R 513 0 R 514 0 R 515 0 R 516 0 R 517 0 R 518 0 R 519 0 R 520 0 R 521 0 R 522 0 R 523 0 R 524 0 R 525 0 R 526 0 R 527 0 R 528 0 R 529 0 R] /Type /StructElem /S /P >> endobj 416 0 obj << /Pg 25 0 R /P 169 0 R /K [90] /ActualText (T) /Type /StructElem /S /Span >> endobj 417 0 obj << /Pg 25 0 R /P 169 0 R /K [91] /ActualText (o address these gaps) /Type /StructElem /S /Span >> endobj 418 0 obj << /Pg 25 0 R /P 169 0 R /K [92] /ActualText (,) /Type /StructElem /S /Span >> endobj 419 0 obj << /Pg 25 0 R /P 169 0 R /K [93] /ActualText ( ) /Type /StructElem /S /Span >> endobj 420 0 obj << /Pg 25 0 R /P 169 0 R /K [94] /ActualText (we conducted) /Type /StructElem /S /Span >> endobj 421 0 obj << /Pg 25 0 R /P 169 0 R /K [95] /ActualText ( ) /Type /StructElem /S /Span >> endobj 422 0 obj << /Pg 25 0 R /P 169 0 R /K [96] /ActualText (a randomi) /Type /StructElem /S /Span >> endobj 423 0 obj << /Pg 25 0 R /P 169 0 R /K [97] /ActualText (s) /Type /StructElem /S /Span >> endobj 424 0 obj << /Pg 25 0 R /P 169 0 R /K [98] /ActualText (ed, double) /Type /StructElem /S /Span >> endobj 425 0 obj << /Pg 25 0 R /P 169 0 R /K [99] /ActualText (-) /Type /StructElem /S /Span >> endobj 426 0 obj << /Pg 25 0 R /P 169 0 R /K [100] /ActualText (blind, crossover, ) /Type /StructElem /S /Span >> endobj 427 0 obj << /Pg 25 0 R /P 169 0 R /K [101] /ActualText (controlled ) /Type /StructElem /S /Span >> endobj 428 0 obj << /Pg 25 0 R /P 169 0 R /K [102] /ActualText (exposure trial) /Type /StructElem /S /Span >> endobj 429 0 obj << /Pg 25 0 R /P 169 0 R /K [103] /ActualText ( ) /Type /StructElem /S /Span >> endobj 430 0 obj << /Pg 25 0 R /P 169 0 R /K [104] /ActualText (in 30 healthy ) /Type /StructElem /S /Span >> endobj 431 0 obj << /Pg 25 0 R /P 169 0 R /K [105] /ActualText (young adults) /Type /StructElem /S /Span >> endobj 432 0 obj << /Pg 25 0 R /P 169 0 R /K [106] /ActualText ( ) /Type /StructElem /S /Span >> endobj 433 0 obj << /Pg 25 0 R /P 169 0 R /K [107] /ActualText (to explore the respiratory effects ) /Type /StructElem /S /Span >> endobj 434 0 obj << /Pg 25 0 R /P 169 0 R /K [108] /ActualText (of short) /Type /StructElem /S /Span >> endobj 435 0 obj << /Pg 25 0 R /P 169 0 R /K [109] /ActualText (-) /Type /StructElem /S /Span >> endobj 436 0 obj << /Pg 25 0 R /P 169 0 R /K [110] /ActualText (term ozone exposure.) /Type /StructElem /S /Span >> endobj 437 0 obj << /Pg 25 0 R /P 169 0 R /K [111] /ActualText ( ) /Type /StructElem /S /Span >> endobj 438 0 obj << /Pg 25 0 R /P 169 0 R /K [112] /ActualText (The sample size ) /Type /StructElem /S /Span >> endobj 439 0 obj << /Pg 25 0 R /P 169 0 R /K [113] /ActualText (was ) /Type /StructElem /S /Span >> endobj 440 0 obj << /Pg 25 0 R /P 169 0 R /K [114] /ActualText (calculated using an equivalence ) /Type /StructElem /S /Span >> endobj 441 0 obj << /Pg 25 0 R /P 169 0 R /K [115] /ActualText (test, and was ) /Type /StructElem /S /Span >> endobj 442 0 obj << /Pg 25 0 R /P 169 0 R /K [116] /ActualText (comparable to that ) /Type /StructElem /S /Span >> endobj 443 0 obj << /Pg 25 0 R /P 169 0 R /K [117] /ActualText (in) /Type /StructElem /S /Span >> endobj 444 0 obj << /Pg 25 0 R /P 169 0 R /K [118] /ActualText ( ) /Type /StructElem /S /Span >> endobj 445 0 obj << /Pg 25 0 R /P 169 0 R /K [119] /ActualText (previous ) /Type /StructElem /S /Span >> endobj 446 0 obj << /Pg 25 0 R /P 169 0 R /K [120] /ActualText (controlled) /Type /StructElem /S /Span >> endobj 447 0 obj << /Pg 25 0 R /P 169 0 R /K [121] /ActualText ( ) /Type /StructElem /S /Span >> endobj 448 0 obj << /Pg 25 0 R /P 169 0 R /K [122] /ActualText (exposure ) /Type /StructElem /S /Span >> endobj 449 0 obj << /Pg 25 0 R /P 169 0 R /K [123] /ActualText (studies) /Type /StructElem /S /Span >> endobj 450 0 obj << /Pg 25 0 R /P 169 0 R /K [124] /ActualText ( ) /Type /StructElem /S /Span >> endobj 451 0 obj << /Pg 25 0 R /P 169 0 R /K [125] /ActualText ([) /Type /StructElem /S /Span >> endobj 92 0 obj << /Pg 25 0 R /P 169 0 R /K [535 0 R 452 0 R] /Type /StructElem /S /Link >> endobj 535 0 obj << /Pg 25 0 R /Obj 34 0 R /Type /OBJR >> endobj 452 0 obj << /Pg 25 0 R /P 92 0 R /K [126] /ActualText (4) /Type /StructElem /S /Span >> endobj 453 0 obj << /Pg 25 0 R /P 169 0 R /K [127] /ActualText (, ) /Type /StructElem /S /Span >> endobj 93 0 obj << /Pg 25 0 R /P 169 0 R /K [536 0 R 454 0 R 455 0 R 456 0 R] /Type /StructElem /S /Link >> endobj 536 0 obj << /Pg 25 0 R /Obj 35 0 R /Type /OBJR >> endobj 454 0 obj << /Pg 25 0 R /P 93 0 R /K [128] /ActualText (6) /Type /StructElem /S /Span >> endobj 455 0 obj << /Pg 25 0 R /P 93 0 R /K [129] /ActualText (-) /Type /StructElem /S /Span >> endobj 456 0 obj << /Pg 25 0 R /P 93 0 R /K [130] /ActualText (8) /Type /StructElem /S /Span >> endobj 457 0 obj << /Pg 25 0 R /P 169 0 R /K [131] /ActualText (]) /Type /StructElem /S /Span >> endobj 458 0 obj << /Pg 25 0 R /P 169 0 R /K [132] /ActualText (. ) /Type /StructElem /S /Span >> endobj 459 0 obj << /Pg 25 0 R /P 169 0 R /K [133] /ActualText (E) /Type /StructElem /S /Span >> endobj 460 0 obj << /Pg 25 0 R /P 169 0 R /K [134] /ActualText (ach subject was exposed ) /Type /StructElem /S /Span >> endobj 461 0 obj << /Pg 25 0 R /P 169 0 R /K [135] /ActualText (sequentially ) /Type /StructElem /S /Span >> endobj 462 0 obj << /Pg 25 0 R /P 169 0 R /K [136] /ActualText (to both filtered air and 200 ppb ozone for ) /Type /StructElem /S /Span >> endobj 463 0 obj << /Pg 25 0 R /P 169 0 R /K [137] /ActualText (continuous 2 ) /Type /StructElem /S /Span >> endobj 464 0 obj << /Pg 25 0 R /P 169 0 R /K [138] /ActualText (hours in random order) /Type /StructElem /S /Span >> endobj 465 0 obj << /Pg 25 0 R /P 169 0 R /K [139] /ActualText (. ) /Type /StructElem /S /Span >> endobj 466 0 obj << /Pg 25 0 R /P 169 0 R /K [140] /ActualText (A) /Type /StructElem /S /Span >> endobj 467 0 obj << /Pg 25 0 R /P 169 0 R /K [141] /ActualText ( ) /Type /StructElem /S /Span >> endobj 468 0 obj << /Pg 25 0 R /P 169 0 R /K [142] /ActualText (washout period) /Type /StructElem /S /Span >> endobj 469 0 obj << /Pg 25 0 R /P 169 0 R /K [143] /ActualText ( ) /Type /StructElem /S /Span >> endobj 470 0 obj << /Pg 25 0 R /P 169 0 R /K [144] /ActualText (of ) /Type /StructElem /S /Span >> endobj 471 0 obj << /Pg 25 0 R /P 169 0 R /K [145] /ActualText (at least 2 weeks) /Type /StructElem /S /Span >> endobj 472 0 obj << /Pg 25 0 R /P 169 0 R /K [146] /ActualText ( ) /Type /StructElem /S /Span >> endobj 473 0 obj << /Pg 25 0 R /P 169 0 R /K [147] /ActualText (was ) /Type /StructElem /S /Span >> endobj 474 0 obj << /Pg 25 0 R /P 169 0 R /K [148] /ActualText (determined according to previous controlled) /Type /StructElem /S /Span >> endobj 475 0 obj << /Pg 25 0 R /P 169 0 R /K [149] /ActualText ( ) /Type /StructElem /S /Span >> endobj 476 0 obj << /Pg 25 0 R /P 169 0 R /K [150] /ActualText (exposure trials) /Type /StructElem /S /Span >> endobj 477 0 obj << /Pg 25 0 R /P 169 0 R /K [151] /ActualText ( ) /Type /StructElem /S /Span >> endobj 478 0 obj << /Pg 25 0 R /P 169 0 R /K [152] /ActualText ([) /Type /StructElem /S /Span >> endobj 94 0 obj << /Pg 25 0 R /P 169 0 R /K [537 0 R 479 0 R] /Type /StructElem /S /Link >> endobj 537 0 obj << /Pg 25 0 R /Obj 36 0 R /Type /OBJR >> endobj 479 0 obj << /Pg 25 0 R /P 94 0 R /K [153] /ActualText (8) /Type /StructElem /S /Span >> endobj 480 0 obj << /Pg 25 0 R /P 169 0 R /K [154] /ActualText (, ) /Type /StructElem /S /Span >> endobj 95 0 obj << /Pg 25 0 R /P 169 0 R /K [538 0 R 481 0 R] /Type /StructElem /S /Link >> endobj 538 0 obj << /Pg 25 0 R /Obj 37 0 R /Type /OBJR >> endobj 481 0 obj << /Pg 25 0 R /P 95 0 R /K [155] /ActualText (9) /Type /StructElem /S /Span >> endobj 482 0 obj << /Pg 25 0 R /P 169 0 R /K [156] /ActualText (]) /Type /StructElem /S /Span >> endobj 483 0 obj << /Pg 25 0 R /P 169 0 R /K [157] /ActualText (. ) /Type /StructElem /S /Span >> endobj 484 0 obj << /Pg 25 0 R /P 169 0 R /K [158] /ActualText (Lung function ) /Type /StructElem /S /Span >> endobj 485 0 obj << /Pg 25 0 R /P 169 0 R /K [159] /ActualText (w) /Type /StructElem /S /Span >> endobj 486 0 obj << /Pg 25 0 R /P 169 0 R /K [160] /ActualText (as) /Type /StructElem /S /Span >> endobj 487 0 obj << /Pg 25 0 R /P 169 0 R /K [161] /ActualText ( ) /Type /StructElem /S /Span >> endobj 488 0 obj << /Pg 25 0 R /P 169 0 R /K [162] /ActualText (measured according to the recommen) /Type /StructElem /S /Span >> endobj 489 0 obj << /Pg 25 0 R /P 169 0 R /K [163] /ActualText (ded methods ) /Type /StructElem /S /Span >> endobj 490 0 obj << /Pg 25 0 R /P 169 0 R /K [164] /ActualText ([) /Type /StructElem /S /Span >> endobj 96 0 obj << /Pg 25 0 R /P 169 0 R /K [539 0 R 491 0 R] /Type /StructElem /S /Link >> endobj 539 0 obj << /Pg 25 0 R /Obj 38 0 R /Type /OBJR >> endobj 491 0 obj << /Pg 25 0 R /P 96 0 R /K [165] /ActualText (10) /Type /StructElem /S /Span >> endobj 492 0 obj << /Pg 25 0 R /P 169 0 R /K [166] /ActualText (]) /Type /StructElem /S /Span >> endobj 493 0 obj << /Pg 25 0 R /P 169 0 R /K [167] /ActualText (. As a well) /Type /StructElem /S /Span >> endobj 494 0 obj << /Pg 25 0 R /P 169 0 R /K [168] /ActualText (-) /Type /StructElem /S /Span >> endobj 495 0 obj << /Pg 25 0 R /P 169 0 R /K [169] /ActualText (established ) /Type /StructElem /S /Span >> endobj 496 0 obj << /Pg 25 0 R /P 169 0 R /K [170] /ActualText (biomarker of lung epithelial injury, s) /Type /StructElem /S /Span >> endobj 497 0 obj << /Pg 25 0 R /P 169 0 R /K [171] /ActualText (erum ) /Type /StructElem /S /Span >> endobj 498 0 obj << /Pg 25 0 R /P 169 0 R /K [172] /ActualText (Clara cell protein \(CC16\)) /Type /StructElem /S /Span >> endobj 499 0 obj << /Pg 25 0 R /P 169 0 R /K [173] /ActualText ( ) /Type /StructElem /S /Span >> endobj 500 0 obj << /Pg 25 0 R /P 169 0 R /K [174] /ActualText (was ) /Type /StructElem /S /Span >> endobj 501 0 obj << /Pg 25 0 R /P 169 0 R /K [175] /ActualText (measured ) /Type /StructElem /S /Span >> endobj 502 0 obj << /Pg 25 0 R /P 169 0 R /K [176] /ActualText (using enzyme) /Type /StructElem /S /Span >> endobj 503 0 obj << /Pg 25 0 R /P 169 0 R /K [177] /ActualText (-) /Type /StructElem /S /Span >> endobj 504 0 obj << /Pg 25 0 R /P 169 0 R /K [178] /ActualText (linked immunosorbent assays) /Type /StructElem /S /Span >> endobj 505 0 obj << /Pg 25 0 R /P 169 0 R /K [179] /ActualText (.) /Type /StructElem /S /Span >> endobj 506 0 obj << /Pg 25 0 R /P 169 0 R /K [180] /ActualText ( ) /Type /StructElem /S /Span >> endobj 507 0 obj << /Pg 25 0 R /P 169 0 R /K [181] /ActualText (Respiratory microbiota was analyzed ) /Type /StructElem /S /Span >> endobj 508 0 obj << /Pg 25 0 R /P 169 0 R /K [182] /ActualText (with) /Type /StructElem /S /Span >> endobj 509 0 obj << /Pg 25 0 R /P 169 0 R /K [183] /ActualText ( ) /Type /StructElem /S /Span >> endobj 510 0 obj << /Pg 25 0 R /P 169 0 R /K [184] /ActualText (the) /Type /StructElem /S /Span >> endobj 511 0 obj << /Pg 25 0 R /P 169 0 R /K [185] /ActualText ( ) /Type /StructElem /S /Span >> endobj 512 0 obj << /Pg 25 0 R /P 169 0 R /K [186] /ActualText (nasal se) /Type /StructElem /S /Span >> endobj 513 0 obj << /Pg 25 0 R /P 169 0 R /K [187] /ActualText (cretion) /Type /StructElem /S /Span >> endobj 514 0 obj << /Pg 25 0 R /P 169 0 R /K [188] /ActualText ( ) /Type /StructElem /S /Span >> endobj 515 0 obj << /Pg 25 0 R /P 169 0 R /K [189] /ActualText (using) /Type /StructElem /S /Span >> endobj 516 0 obj << /Pg 25 0 R /P 169 0 R /K [190] /ActualText ( ) /Type /StructElem /S /Span >> endobj 517 0 obj << /Pg 25 0 R /P 169 0 R /K [191] /ActualText (16S rRNA amplicon sequencing) /Type /StructElem /S /Span >> endobj 518 0 obj << /Pg 25 0 R /P 169 0 R /K [192] /ActualText (.) /Type /StructElem /S /Span >> endobj 519 0 obj << /Pg 25 0 R /P 169 0 R /K [193] /ActualText ( ) /Type /StructElem /S /Span >> endobj 520 0 obj << /Pg 25 0 R /P 169 0 R /K [194] /ActualText (Airway metabolome ) /Type /StructElem /S /Span >> endobj 521 0 obj << /Pg 25 0 R /P 169 0 R /K [195] /ActualText (was analyzed ) /Type /StructElem /S /Span >> endobj 522 0 obj << /Pg 25 0 R /P 169 0 R /K [196] /ActualText (with) /Type /StructElem /S /Span >> endobj 523 0 obj << /Pg 25 0 R /P 169 0 R /K [197] /ActualText ( ) /Type /StructElem /S /Span >> endobj 524 0 obj << /Pg 25 0 R /P 169 0 R /K [198] /ActualText (the exhaled breath condensate) /Type /StructElem /S /Span >> endobj 525 0 obj << /Pg 25 0 R /P 169 0 R /K [199] /ActualText ( ) /Type /StructElem /S /Span >> endobj 526 0 obj << /Pg 25 0 R /P 169 0 R /K [200] /ActualText (\(EBC\)) /Type /StructElem /S /Span >> endobj 527 0 obj << /Pg 25 0 R /P 169 0 R /K [201] /ActualText ( ) /Type /StructElem /S /Span >> endobj 528 0 obj << /Pg 25 0 R /P 169 0 R /K [202] /ActualText (using ) /Type /StructElem /S /Span >> endobj 529 0 obj << /Pg 25 0 R /P 169 0 R /K [203] /ActualText (gas ) /Type /StructElem /S /Span >> endobj 170 0 obj << /Pg 42 0 R /P 81 0 R /K [540 0 R 541 0 R 542 0 R 543 0 R 544 0 R 545 0 R 546 0 R 547 0 R 548 0 R 549 0 R 550 0 R 551 0 R 552 0 R] /Type /StructElem /S /P >> endobj 540 0 obj << /Pg 42 0 R /P 170 0 R /K [0] /ActualText (chromatography) /Type /StructElem /S /Span >> endobj 97 0 obj [540 0 R 541 0 R 542 0 R 543 0 R 544 0 R 545 0 R 546 0 R 547 0 R 548 0 R 549 0 R 550 0 R 551 0 R 552 0 R 553 0 R 554 0 R 555 0 R 556 0 R 557 0 R 558 0 R 559 0 R 560 0 R 561 0 R 562 0 R 563 0 R 564 0 R 565 0 R 566 0 R 567 0 R 568 0 R 569 0 R 570 0 R 571 0 R 572 0 R 573 0 R 574 0 R 575 0 R 576 0 R 577 0 R 578 0 R 579 0 R 580 0 R 581 0 R 582 0 R 583 0 R 584 0 R 585 0 R 586 0 R 587 0 R 588 0 R 589 0 R 590 0 R 591 0 R 592 0 R 593 0 R 594 0 R 595 0 R 596 0 R 597 0 R 598 0 R 599 0 R 600 0 R 601 0 R 602 0 R 603 0 R 604 0 R 605 0 R 606 0 R 607 0 R 608 0 R 609 0 R 610 0 R 611 0 R 612 0 R 613 0 R 614 0 R 615 0 R 616 0 R 617 0 R 618 0 R 619 0 R 620 0 R 621 0 R 622 0 R 623 0 R 624 0 R 625 0 R 626 0 R 627 0 R 628 0 R 629 0 R 630 0 R 631 0 R 632 0 R 633 0 R 634 0 R 635 0 R 636 0 R 637 0 R 638 0 R 639 0 R 640 0 R 641 0 R 642 0 R 643 0 R 644 0 R 645 0 R 646 0 R 647 0 R 648 0 R 649 0 R 650 0 R 651 0 R 652 0 R 653 0 R 654 0 R 655 0 R 656 0 R 657 0 R 658 0 R 659 0 R 660 0 R 661 0 R 662 0 R 663 0 R 664 0 R 665 0 R 666 0 R 667 0 R 668 0 R 669 0 R 670 0 R 671 0 R 672 0 R 673 0 R 674 0 R 675 0 R 676 0 R 677 0 R 678 0 R 679 0 R 680 0 R 681 0 R 682 0 R 683 0 R 684 0 R 685 0 R 686 0 R 687 0 R 688 0 R 689 0 R 690 0 R 691 0 R 692 0 R 693 0 R 694 0 R 695 0 R 696 0 R 697 0 R 698 0 R 699 0 R 700 0 R 701 0 R 702 0 R 703 0 R 704 0 R 705 0 R 706 0 R 707 0 R 708 0 R 709 0 R 710 0 R 711 0 R 712 0 R 713 0 R 714 0 R] endobj 541 0 obj << /Pg 42 0 R /P 170 0 R /K [1] /ActualText (-) /Type /StructElem /S /Span >> endobj 542 0 obj << /Pg 42 0 R /P 170 0 R /K [2] /ActualText (time of flight) /Type /StructElem /S /Span >> endobj 543 0 obj << /Pg 42 0 R /P 170 0 R /K [3] /ActualText (-) /Type /StructElem /S /Span >> endobj 544 0 obj << /Pg 42 0 R /P 170 0 R /K [4] /ActualText (mass spectrometry) /Type /StructElem /S /Span >> endobj 545 0 obj << /Pg 42 0 R /P 170 0 R /K [5] /ActualText ( ) /Type /StructElem /S /Span >> endobj 546 0 obj << /Pg 42 0 R /P 170 0 R /K [6] /ActualText (\(GC) /Type /StructElem /S /Span >> endobj 547 0 obj << /Pg 42 0 R /P 170 0 R /K [7] /ActualText (-) /Type /StructElem /S /Span >> endobj 548 0 obj << /Pg 42 0 R /P 170 0 R /K [8] /ActualText (TOF) /Type /StructElem /S /Span >> endobj 549 0 obj << /Pg 42 0 R /P 170 0 R /K [9] /ActualText (-) /Type /StructElem /S /Span >> endobj 550 0 obj << /Pg 42 0 R /P 170 0 R /K [10] /ActualText (MS\)) /Type /StructElem /S /Span >> endobj 551 0 obj << /Pg 42 0 R /P 170 0 R /K [11] /ActualText (.) /Type /StructElem /S /Span >> endobj 552 0 obj << /Pg 42 0 R /P 170 0 R /K [12] /ActualText ( ) /Type /StructElem /S /Span >> endobj 171 0 obj << /Pg 42 0 R /P 81 0 R /K [553 0 R 554 0 R 555 0 R 556 0 R 557 0 R 558 0 R 559 0 R 560 0 R 561 0 R 562 0 R 563 0 R 564 0 R 565 0 R 566 0 R 567 0 R 568 0 R 569 0 R 570 0 R 571 0 R 572 0 R 573 0 R 574 0 R 575 0 R 576 0 R 577 0 R 578 0 R 579 0 R 580 0 R 581 0 R 582 0 R 583 0 R 584 0 R 585 0 R 586 0 R 587 0 R 588 0 R 589 0 R 590 0 R 591 0 R 592 0 R 593 0 R 594 0 R 595 0 R 596 0 R 597 0 R 598 0 R 599 0 R 600 0 R 601 0 R 602 0 R 603 0 R 604 0 R 605 0 R 606 0 R 607 0 R 608 0 R 609 0 R 610 0 R 611 0 R 612 0 R 613 0 R 614 0 R 615 0 R 616 0 R 617 0 R 618 0 R 619 0 R 620 0 R 621 0 R 622 0 R 623 0 R 624 0 R 625 0 R 626 0 R 627 0 R 628 0 R 629 0 R 630 0 R 631 0 R 632 0 R 633 0 R 634 0 R 635 0 R 636 0 R 637 0 R 638 0 R 639 0 R 640 0 R 641 0 R 642 0 R 643 0 R 644 0 R 645 0 R 646 0 R 647 0 R 648 0 R 649 0 R 650 0 R 651 0 R 652 0 R 653 0 R 654 0 R 655 0 R 656 0 R 657 0 R 658 0 R 659 0 R 660 0 R 661 0 R 662 0 R 663 0 R 664 0 R 665 0 R 666 0 R 667 0 R 668 0 R 669 0 R 670 0 R 671 0 R 672 0 R 673 0 R 674 0 R 675 0 R 676 0 R 677 0 R 678 0 R 679 0 R 680 0 R 681 0 R 682 0 R 683 0 R 684 0 R 685 0 R 686 0 R 687 0 R 688 0 R 689 0 R 690 0 R 691 0 R 692 0 R 693 0 R 694 0 R 695 0 R 696 0 R] /Type /StructElem /S /P >> endobj 553 0 obj << /Pg 42 0 R /P 171 0 R /K [13] /ActualText (W) /Type /StructElem /S /Span >> endobj 554 0 obj << /Pg 42 0 R /P 171 0 R /K [14] /ActualText (e applied linear mixed) /Type /StructElem /S /Span >> endobj 555 0 obj << /Pg 42 0 R /P 171 0 R /K [15] /ActualText (-) /Type /StructElem /S /Span >> endobj 556 0 obj << /Pg 42 0 R /P 171 0 R /K [16] /ActualText (effect \(LME\) model) /Type /StructElem /S /Span >> endobj 557 0 obj << /Pg 42 0 R /P 171 0 R /K [17] /ActualText (s) /Type /StructElem /S /Span >> endobj 558 0 obj << /Pg 42 0 R /P 171 0 R /K [18] /ActualText ( ) /Type /StructElem /S /Span >> endobj 559 0 obj << /Pg 42 0 R /P 171 0 R /K [19] /ActualText (to ) /Type /StructElem /S /Span >> endobj 560 0 obj << /Pg 42 0 R /P 171 0 R /K [20] /ActualText (estimate) /Type /StructElem /S /Span >> endobj 561 0 obj << /Pg 42 0 R /P 171 0 R /K [21] /ActualText ( ) /Type /StructElem /S /Span >> endobj 562 0 obj << /Pg 42 0 R /P 171 0 R /K [22] /ActualText (the acute ) /Type /StructElem /S /Span >> endobj 563 0 obj << /Pg 42 0 R /P 171 0 R /K [23] /ActualText (effects of ) /Type /StructElem /S /Span >> endobj 564 0 obj << /Pg 42 0 R /P 171 0 R /K [24] /ActualText (ozone exposure on) /Type /StructElem /S /Span >> endobj 565 0 obj << /Pg 42 0 R /P 171 0 R /K [25] /ActualText ( ) /Type /StructElem /S /Span >> endobj 566 0 obj << /Pg 42 0 R /P 171 0 R /K [26] /ActualText (lung function and serum CC16) /Type /StructElem /S /Span >> endobj 567 0 obj << /Pg 42 0 R /P 171 0 R /K [27] /ActualText (.) /Type /StructElem /S /Span >> endobj 568 0 obj << /Pg 42 0 R /P 171 0 R /K [28] /ActualText ( ) /Type /StructElem /S /Span >> endobj 569 0 obj << /Pg 42 0 R /P 171 0 R /K [29] /ActualText (For ) /Type /StructElem /S /Span >> endobj 570 0 obj << /Pg 42 0 R /P 171 0 R /K [30] /ActualText (microbiota) /Type /StructElem /S /Span >> endobj 571 0 obj << /Pg 42 0 R /P 171 0 R /K [31] /ActualText ( ) /Type /StructElem /S /Span >> endobj 572 0 obj << /Pg 42 0 R /P 171 0 R /K [32] /ActualText (analysis, ) /Type /StructElem /S /Span >> endobj 573 0 obj << /Pg 42 0 R /P 171 0 R /K [33] /ActualText (we ) /Type /StructElem /S /Span >> endobj 574 0 obj << /Pg 42 0 R /P 171 0 R /K [34] /ActualText (firstly ) /Type /StructElem /S /Span >> endobj 575 0 obj << /Pg 42 0 R /P 171 0 R /K [35] /ActualText (evaluated alpha) /Type /StructElem /S /Span >> endobj 576 0 obj << /Pg 42 0 R /P 171 0 R /K [36] /ActualText (-) /Type /StructElem /S /Span >> endobj 577 0 obj << /Pg 42 0 R /P 171 0 R /K [37] /ActualText (diversity by calculating abundance) /Type /StructElem /S /Span >> endobj 578 0 obj << /Pg 42 0 R /P 171 0 R /K [38] /ActualText (-) /Type /StructElem /S /Span >> endobj 579 0 obj << /Pg 42 0 R /P 171 0 R /K [39] /ActualText (based coverage estimator \(ACE\), ) /Type /StructElem /S /Span >> endobj 580 0 obj << /Pg 42 0 R /P 171 0 R /K [40] /ActualText (Simpson, and Shannon) /Type /StructElem /S /Span >> endobj 581 0 obj << /Pg 42 0 R /P 171 0 R /K [41] /ActualText (;) /Type /StructElem /S /Span >> endobj 582 0 obj << /Pg 42 0 R /P 171 0 R /K [42] /ActualText ( ) /Type /StructElem /S /Span >> endobj 583 0 obj << /Pg 42 0 R /P 171 0 R /K [43] /ActualText (t) /Type /StructElem /S /Span >> endobj 584 0 obj << /Pg 42 0 R /P 171 0 R /K [44] /ActualText (hen, we assessed b) /Type /StructElem /S /Span >> endobj 585 0 obj << /Pg 42 0 R /P 171 0 R /K [45] /ActualText (eta) /Type /StructElem /S /Span >> endobj 586 0 obj << /Pg 42 0 R /P 171 0 R /K [46] /ActualText (-) /Type /StructElem /S /Span >> endobj 587 0 obj << /Pg 42 0 R /P 171 0 R /K [47] /ActualText (diversity ) /Type /StructElem /S /Span >> endobj 588 0 obj << /Pg 42 0 R /P 171 0 R /K [48] /ActualText (by calculating) /Type /StructElem /S /Span >> endobj 589 0 obj << /Pg 42 0 R /P 171 0 R /K [49] /ActualText ( ) /Type /StructElem /S /Span >> endobj 590 0 obj << /Pg 42 0 R /P 171 0 R /K [50] /ActualText (weighted) /Type /StructElem /S /Span >> endobj 591 0 obj << /Pg 42 0 R /P 171 0 R /K [51] /ActualText ( ) /Type /StructElem /S /Span >> endobj 592 0 obj << /Pg 42 0 R /P 171 0 R /K [52] /ActualText (Unifrac distance and visualiz) /Type /StructElem /S /Span >> endobj 593 0 obj << /Pg 42 0 R /P 171 0 R /K [53] /ActualText (ing it) /Type /StructElem /S /Span >> endobj 594 0 obj << /Pg 42 0 R /P 171 0 R /K [54] /ActualText ( ) /Type /StructElem /S /Span >> endobj 595 0 obj << /Pg 42 0 R /P 171 0 R /K [55] /ActualText (via principal coordinate analysis) /Type /StructElem /S /Span >> endobj 596 0 obj << /Pg 42 0 R /P 171 0 R /K [56] /ActualText (;) /Type /StructElem /S /Span >> endobj 597 0 obj << /Pg 42 0 R /P 171 0 R /K [57] /ActualText ( ) /Type /StructElem /S /Span >> endobj 598 0 obj << /Pg 42 0 R /P 171 0 R /K [58] /ActualText (l) /Type /StructElem /S /Span >> endobj 599 0 obj << /Pg 42 0 R /P 171 0 R /K [59] /ActualText (ast) /Type /StructElem /S /Span >> endobj 600 0 obj << /Pg 42 0 R /P 171 0 R /K [60] /ActualText (ly) /Type /StructElem /S /Span >> endobj 601 0 obj << /Pg 42 0 R /P 171 0 R /K [61] /ActualText (,) /Type /StructElem /S /Span >> endobj 602 0 obj << /Pg 42 0 R /P 171 0 R /K [62] /ActualText ( ) /Type /StructElem /S /Span >> endobj 603 0 obj << /Pg 42 0 R /P 171 0 R /K [63] /ActualText (we identified) /Type /StructElem /S /Span >> endobj 604 0 obj << /Pg 42 0 R /P 171 0 R /K [64] /ActualText ( ) /Type /StructElem /S /Span >> endobj 605 0 obj << /Pg 42 0 R /P 171 0 R /K [65] /ActualText (taxa characterizing the differences ) /Type /StructElem /S /Span >> endobj 606 0 obj << /Pg 42 0 R /P 171 0 R /K [66] /ActualText (between ) /Type /StructElem /S /Span >> endobj 607 0 obj << /Pg 42 0 R /P 171 0 R /K [67] /ActualText (ozone and ) /Type /StructElem /S /Span >> endobj 608 0 obj << /Pg 42 0 R /P 171 0 R /K [68] /ActualText (filtered air) /Type /StructElem /S /Span >> endobj 609 0 obj << /Pg 42 0 R /P 171 0 R /K [69] /ActualText ( ) /Type /StructElem /S /Span >> endobj 610 0 obj << /Pg 42 0 R /P 171 0 R /K [70] /ActualText (groups using a ) /Type /StructElem /S /Span >> endobj 611 0 obj << /Pg 42 0 R /P 171 0 R /K [71] /ActualText (linear discrimina) /Type /StructElem /S /Span >> endobj 612 0 obj << /Pg 42 0 R /P 171 0 R /K [72] /ActualText (nt effect size) /Type /StructElem /S /Span >> endobj 613 0 obj << /Pg 42 0 R /P 171 0 R /K [73] /ActualText ( ) /Type /StructElem /S /Span >> endobj 614 0 obj << /Pg 42 0 R /P 171 0 R /K [74] /ActualText (analysis) /Type /StructElem /S /Span >> endobj 615 0 obj << /Pg 42 0 R /P 171 0 R /K [75] /ActualText (, and a taxon) /Type /StructElem /S /Span >> endobj 616 0 obj << /Pg 42 0 R /P 171 0 R /K [76] /ActualText ( ) /Type /StructElem /S /Span >> endobj 617 0 obj << /Pg 42 0 R /P 171 0 R /K [77] /ActualText (with ) /Type /StructElem /S /Span >> endobj 618 0 obj << /Pg 42 0 R /P 171 0 R /K [78] /ActualText (a li) /Type /StructElem /S /Span >> endobj 619 0 obj << /Pg 42 0 R /P 171 0 R /K [79] /ActualText (near discriminant) /Type /StructElem /S /Span >> endobj 620 0 obj << /Pg 42 0 R /P 171 0 R /K [80] /ActualText ( ) /Type /StructElem /S /Span >> endobj 621 0 obj << /Pg 42 0 R /P 171 0 R /K [81] /ActualText (analysis) /Type /StructElem /S /Span >> endobj 622 0 obj << /Pg 42 0 R /P 171 0 R /K [82] /ActualText ( ) /Type /StructElem /S /Span >> endobj 623 0 obj << /Pg 42 0 R /P 171 0 R /K [83] /ActualText (score >) /Type /StructElem /S /Span >> endobj 624 0 obj << /Pg 42 0 R /P 171 0 R /K [84] /ActualText ( ) /Type /StructElem /S /Span >> endobj 625 0 obj << /Pg 42 0 R /P 171 0 R /K [85] /ActualText (4) /Type /StructElem /S /Span >> endobj 626 0 obj << /Pg 42 0 R /P 171 0 R /K [86] /ActualText ( ) /Type /StructElem /S /Span >> endobj 627 0 obj << /Pg 42 0 R /P 171 0 R /K [87] /ActualText (was ) /Type /StructElem /S /Span >> endobj 628 0 obj << /Pg 42 0 R /P 171 0 R /K [88] /ActualText (considered significantly different between two groups) /Type /StructElem /S /Span >> endobj 629 0 obj << /Pg 42 0 R /P 171 0 R /K [89] /ActualText (.) /Type /StructElem /S /Span >> endobj 630 0 obj << /Pg 42 0 R /P 171 0 R /K [90] /ActualText ( ) /Type /StructElem /S /Span >> endobj 631 0 obj << /Pg 42 0 R /P 171 0 R /K [91] /ActualText (For ) /Type /StructElem /S /Span >> endobj 632 0 obj << /Pg 42 0 R /P 171 0 R /K [92] /ActualText (m) /Type /StructElem /S /Span >> endobj 633 0 obj << /Pg 42 0 R /P 171 0 R /K [93] /ActualText (etabolomics analyses) /Type /StructElem /S /Span >> endobj 634 0 obj << /Pg 42 0 R /P 171 0 R /K [94] /ActualText (,) /Type /StructElem /S /Span >> endobj 635 0 obj << /Pg 42 0 R /P 171 0 R /K [95] /ActualText ( ) /Type /StructElem /S /Span >> endobj 636 0 obj << /Pg 42 0 R /P 171 0 R /K [96] /ActualText (we ) /Type /StructElem /S /Span >> endobj 637 0 obj << /Pg 42 0 R /P 171 0 R /K [97] /ActualText (firstly ) /Type /StructElem /S /Span >> endobj 638 0 obj << /Pg 42 0 R /P 171 0 R /K [98] /ActualText (conducted ) /Type /StructElem /S /Span >> endobj 639 0 obj << /Pg 42 0 R /P 171 0 R /K [99] /ActualText (an ) /Type /StructElem /S /Span >> endobj 640 0 obj << /Pg 42 0 R /P 171 0 R /K [100] /ActualText (orthogonal partial least squares ) /Type /StructElem /S /Span >> endobj 641 0 obj << /Pg 42 0 R /P 171 0 R /K [101] /ActualText (discriminant analysis) /Type /StructElem /S /Span >> endobj 642 0 obj << /Pg 42 0 R /P 171 0 R /K [102] /ActualText ( ) /Type /StructElem /S /Span >> endobj 643 0 obj << /Pg 42 0 R /P 171 0 R /K [103] /ActualText (and ) /Type /StructElem /S /Span >> endobj 644 0 obj << /Pg 42 0 R /P 171 0 R /K [104] /ActualText (used the variance importance in the projection \(VIP\)) /Type /StructElem /S /Span >> endobj 645 0 obj << /Pg 42 0 R /P 171 0 R /K [105] /ActualText ( ) /Type /StructElem /S /Span >> endobj 646 0 obj << /Pg 42 0 R /P 171 0 R /K [106] /ActualText (scores ) /Type /StructElem /S /Span >> endobj 647 0 obj << /Pg 42 0 R /P 171 0 R /K [107] /ActualText (to define contributions ) /Type /StructElem /S /Span >> endobj 648 0 obj << /Pg 42 0 R /P 171 0 R /K [108] /ActualText (of) /Type /StructElem /S /Span >> endobj 649 0 obj << /Pg 42 0 R /P 171 0 R /K [109] /ActualText ( ) /Type /StructElem /S /Span >> endobj 650 0 obj << /Pg 42 0 R /P 171 0 R /K [110] /ActualText (each ) /Type /StructElem /S /Span >> endobj 651 0 obj << /Pg 42 0 R /P 171 0 R /K [111] /ActualText (metabolite to) /Type /StructElem /S /Span >> endobj 652 0 obj << /Pg 42 0 R /P 171 0 R /K [112] /ActualText ( ) /Type /StructElem /S /Span >> endobj 653 0 obj << /Pg 42 0 R /P 171 0 R /K [113] /ActualText (the overall between) /Type /StructElem /S /Span >> endobj 654 0 obj << /Pg 42 0 R /P 171 0 R /K [114] /ActualText (-) /Type /StructElem /S /Span >> endobj 655 0 obj << /Pg 42 0 R /P 171 0 R /K [115] /ActualText (group difference) /Type /StructElem /S /Span >> endobj 656 0 obj << /Pg 42 0 R /P 171 0 R /K [116] /ActualText (;) /Type /StructElem /S /Span >> endobj 657 0 obj << /Pg 42 0 R /P 171 0 R /K [117] /ActualText ( ) /Type /StructElem /S /Span >> endobj 658 0 obj << /Pg 42 0 R /P 171 0 R /K [118] /ActualText (then,) /Type /StructElem /S /Span >> endobj 659 0 obj << /Pg 42 0 R /P 171 0 R /K [119] /ActualText ( ) /Type /StructElem /S /Span >> endobj 660 0 obj << /Pg 42 0 R /P 171 0 R /K [120] /ActualText (f) /Type /StructElem /S /Span >> endobj 661 0 obj << /Pg 42 0 R /P 171 0 R /K [121] /ActualText (or ) /Type /StructElem /S /Span >> endobj 662 0 obj << /Pg 42 0 R /P 171 0 R /K [122] /ActualText (metabolite) /Type /StructElem /S /Span >> endobj 663 0 obj << /Pg 42 0 R /P 171 0 R /K [123] /ActualText (s) /Type /StructElem /S /Span >> endobj 664 0 obj << /Pg 42 0 R /P 171 0 R /K [124] /ActualText ( ) /Type /StructElem /S /Span >> endobj 665 0 obj << /Pg 42 0 R /P 171 0 R /K [125] /ActualText (with ) /Type /StructElem /S /Span >> endobj 666 0 obj << /Pg 42 0 R /P 171 0 R /K [126] /ActualText (a ) /Type /StructElem /S /Span >> endobj 667 0 obj << /Pg 42 0 R /P 171 0 R /K [127] /ActualText (VIP score) /Type /StructElem /S /Span >> endobj 668 0 obj << /Pg 42 0 R /P 171 0 R /K [128] /ActualText ( ) /Type /StructElem /S /Span >> endobj 669 0 obj << /Pg 42 0 R /P 171 0 R /K [129] /ActualText (> 1) /Type /StructElem /S /Span >> endobj 670 0 obj << /Pg 42 0 R /P 171 0 R /K [130] /ActualText (, we) /Type /StructElem /S /Span >> endobj 671 0 obj << /Pg 42 0 R /P 171 0 R /K [131] /ActualText ( ) /Type /StructElem /S /Span >> endobj 672 0 obj << /Pg 42 0 R /P 171 0 R /K [132] /ActualText (used ) /Type /StructElem /S /Span >> endobj 673 0 obj << /Pg 42 0 R /P 171 0 R /K [133] /ActualText (LME models ) /Type /StructElem /S /Span >> endobj 674 0 obj << /Pg 42 0 R /P 171 0 R /K [134] /ActualText (to ) /Type /StructElem /S /Span >> endobj 675 0 obj << /Pg 42 0 R /P 171 0 R /K [135] /ActualText (evaluate the ) /Type /StructElem /S /Span >> endobj 676 0 obj << /Pg 42 0 R /P 171 0 R /K [136] /ActualText (difference) /Type /StructElem /S /Span >> endobj 677 0 obj << /Pg 42 0 R /P 171 0 R /K [137] /ActualText (s) /Type /StructElem /S /Span >> endobj 678 0 obj << /Pg 42 0 R /P 171 0 R /K [138] /ActualText ( ) /Type /StructElem /S /Span >> endobj 679 0 obj << /Pg 42 0 R /P 171 0 R /K [139] /ActualText (between groups. ) /Type /StructElem /S /Span >> endobj 680 0 obj << /Pg 42 0 R /P 171 0 R /K [140] /ActualText (All tests were two) /Type /StructElem /S /Span >> endobj 681 0 obj << /Pg 42 0 R /P 171 0 R /K [141] /ActualText (-) /Type /StructElem /S /Span >> endobj 682 0 obj << /Pg 42 0 R /P 171 0 R /K [142] /ActualText (sided and) /Type /StructElem /S /Span >> endobj 683 0 obj << /Pg 42 0 R /P 171 0 R /K [143] /ActualText ( ) /Type /StructElem /S /Span >> endobj 684 0 obj << /Pg 42 0 R /P 171 0 R /K [144] /ActualText (a p) /Type /StructElem /S /Span >> endobj 685 0 obj << /Pg 42 0 R /P 171 0 R /K [145] /ActualText (-) /Type /StructElem /S /Span >> endobj 686 0 obj << /Pg 42 0 R /P 171 0 R /K [146] /ActualText (value < 0.05 was ) /Type /StructElem /S /Span >> endobj 687 0 obj << /Pg 42 0 R /P 171 0 R /K [147] /ActualText (consider) /Type /StructElem /S /Span >> endobj 688 0 obj << /Pg 42 0 R /P 171 0 R /K [148] /ActualText (ed statistically significant. ) /Type /StructElem /S /Span >> endobj 689 0 obj << /Pg 42 0 R /P 171 0 R /K [149] /ActualText (The study protocol was registered at ) /Type /StructElem /S /Span >> endobj 690 0 obj << /Pg 42 0 R /P 171 0 R /K [150] /ActualText (ClinicalTrials.gov) /Type /StructElem /S /Span >> endobj 691 0 obj << /Pg 42 0 R /P 171 0 R /K [151] /ActualText ( ) /Type /StructElem /S /Span >> endobj 692 0 obj << /Pg 42 0 R /P 171 0 R /K [152] /ActualText (\(NCT03697174\), and ) /Type /StructElem /S /Span >> endobj 693 0 obj << /Pg 42 0 R /P 171 0 R /K [153] /ActualText (a) /Type /StructElem /S /Span >> endobj 694 0 obj << /Pg 42 0 R /P 171 0 R /K [154] /ActualText (ll participants provided written informed ) /Type /StructElem /S /Span >> endobj 695 0 obj << /Pg 42 0 R /P 171 0 R /K [155] /ActualText (consent at enrollment.) /Type /StructElem /S /Span >> endobj 696 0 obj << /Pg 42 0 R /P 171 0 R /K [156] /ActualText ( ) /Type /StructElem /S /Span >> endobj 172 0 obj << /Pg 42 0 R /P 81 0 R /K [697 0 R 698 0 R 699 0 R 700 0 R 701 0 R 702 0 R 703 0 R 704 0 R 705 0 R 706 0 R 707 0 R 708 0 R 709 0 R 710 0 R 711 0 R 712 0 R 713 0 R 714 0 R] /Type /StructElem /S /P >> endobj 697 0 obj << /Pg 42 0 R /P 172 0 R /K [157] /ActualText (O) /Type /StructElem /S /Span >> endobj 698 0 obj << /Pg 42 0 R /P 172 0 R /K [158] /ActualText (zone concentrations) /Type /StructElem /S /Span >> endobj 699 0 obj << /Pg 42 0 R /P 172 0 R /K [159] /ActualText ( ) /Type /StructElem /S /Span >> endobj 700 0 obj << /Pg 42 0 R /P 172 0 R /K [160] /ActualText (in chamber) /Type /StructElem /S /Span >> endobj 701 0 obj << /Pg 42 0 R /P 172 0 R /K [161] /ActualText ( ) /Type /StructElem /S /Span >> endobj 702 0 obj << /Pg 42 0 R /P 172 0 R /K [162] /ActualText (were very close to the target values with ) /Type /StructElem /S /Span >> endobj 703 0 obj << /Pg 42 0 R /P 172 0 R /K [163] /ActualText (an ) /Type /StructElem /S /Span >> endobj 704 0 obj << /Pg 42 0 R /P 172 0 R /K [164] /ActualText (average of ) /Type /StructElem /S /Span >> endobj 705 0 obj << /Pg 42 0 R /P 172 0 R /K [165] /ActualText (201.0 1.6 ppb in the ozone group and 8.0 2.6 ppb in the filtered air ) /Type /StructElem /S /Span >> endobj 706 0 obj << /Pg 42 0 R /P 172 0 R /K [166] /ActualText (group. The levels of fine particulate matter, nitrogen dioxide, temperature and relative ) /Type /StructElem /S /Span >> endobj 707 0 obj << /Pg 42 0 R /P 172 0 R /K [167] /ActualText (humidity were ) /Type /StructElem /S /Span >> endobj 708 0 obj << /Pg 42 0 R /P 172 0 R /K [168] /ActualText (quite similar) /Type /StructElem /S /Span >> endobj 709 0 obj << /Pg 42 0 R /P 172 0 R /K [169] /ActualText ( ) /Type /StructElem /S /Span >> endobj 710 0 obj << /Pg 42 0 R /P 172 0 R /K [170] /ActualText (between the two groups. Relative to the ) /Type /StructElem /S /Span >> endobj 711 0 obj << /Pg 42 0 R /P 172 0 R /K [171] /ActualText (filtered air) /Type /StructElem /S /Span >> endobj 712 0 obj << /Pg 42 0 R /P 172 0 R /K [172] /ActualText ( ) /Type /StructElem /S /Span >> endobj 713 0 obj << /Pg 42 0 R /P 172 0 R /K [173] /ActualText (group, ) /Type /StructElem /S /Span >> endobj 714 0 obj << /Pg 42 0 R /P 172 0 R /K [174] /ActualText (exposure to ozone resulted in significant declines in lung function at lag 2 h, and the ) /Type /StructElem /S /Span >> endobj 173 0 obj << /Pg 45 0 R /P 81 0 R /K [715 0 R 716 0 R 717 0 R 718 0 R 719 0 R 720 0 R 721 0 R 722 0 R 723 0 R 724 0 R 725 0 R 726 0 R 727 0 R 728 0 R 729 0 R 730 0 R 731 0 R 732 0 R 733 0 R 734 0 R 735 0 R 736 0 R 737 0 R 738 0 R 99 0 R 739 0 R 100 0 R 740 0 R 741 0 R 742 0 R 743 0 R] /Type /StructElem /S /P >> endobj 715 0 obj << /Pg 45 0 R /P 173 0 R /K [0] /ActualText (decrements became more prominent at lag 15 h) /Type /StructElem /S /Span >> endobj 98 0 obj [715 0 R 716 0 R 717 0 R 718 0 R 719 0 R 720 0 R 721 0 R 722 0 R 723 0 R 724 0 R 725 0 R 726 0 R 727 0 R 728 0 R 729 0 R 730 0 R 731 0 R 732 0 R 733 0 R 734 0 R 735 0 R 736 0 R 737 0 R 738 0 R 744 0 R 739 0 R 745 0 R 740 0 R 741 0 R 742 0 R 743 0 R 746 0 R 747 0 R 748 0 R 749 0 R 750 0 R 751 0 R 752 0 R 753 0 R 754 0 R 755 0 R 756 0 R 757 0 R 758 0 R 759 0 R 760 0 R 761 0 R 762 0 R 763 0 R 764 0 R 765 0 R 766 0 R 767 0 R 768 0 R 769 0 R 770 0 R 771 0 R 772 0 R 773 0 R 774 0 R 775 0 R 776 0 R 777 0 R 778 0 R 779 0 R 780 0 R 781 0 R 782 0 R 783 0 R 784 0 R 785 0 R 786 0 R 787 0 R 788 0 R 789 0 R 790 0 R 791 0 R 792 0 R 793 0 R 794 0 R 795 0 R 796 0 R 797 0 R 798 0 R 799 0 R 800 0 R 801 0 R 802 0 R 803 0 R 804 0 R 805 0 R 806 0 R 807 0 R 808 0 R 809 0 R 810 0 R 811 0 R 812 0 R 813 0 R 814 0 R 815 0 R 816 0 R 817 0 R 818 0 R 819 0 R 820 0 R 821 0 R 822 0 R 823 0 R 824 0 R 825 0 R 826 0 R 827 0 R 828 0 R 829 0 R 830 0 R 831 0 R 832 0 R 833 0 R 834 0 R 835 0 R 836 0 R 837 0 R 838 0 R 839 0 R 840 0 R 841 0 R 842 0 R 843 0 R] endobj 716 0 obj << /Pg 45 0 R /P 173 0 R /K [1] /ActualText ( ) /Type /StructElem /S /Span >> endobj 717 0 obj << /Pg 45 0 R /P 173 0 R /K [2] /ActualText (in ) /Type /StructElem /S /Span >> endobj 718 0 obj << /Pg 45 0 R /P 173 0 R /K [3] /ActualText (the next morning) /Type /StructElem /S /Span >> endobj 719 0 obj << /Pg 45 0 R /P 173 0 R /K [4] /ActualText (. At lag) /Type /StructElem /S /Span >> endobj 720 0 obj << /Pg 45 0 R /P 173 0 R /K [5] /ActualText ( ) /Type /StructElem /S /Span >> endobj 721 0 obj << /Pg 45 0 R /P 173 0 R /K [6] /ActualText (15 h) /Type /StructElem /S /Span >> endobj 722 0 obj << /Pg 45 0 R /P 173 0 R /K [7] /ActualText (, there ) /Type /StructElem /S /Span >> endobj 723 0 obj << /Pg 45 0 R /P 173 0 R /K [8] /ActualText (were decrements of 3.70% [95% confidence interval \(CI\): 0.58%, 6.82%] in fo) /Type /StructElem /S /Span >> endobj 724 0 obj << /Pg 45 0 R /P 173 0 R /K [9] /ActualText (rced ) /Type /StructElem /S /Span >> endobj 725 0 obj << /Pg 45 0 R /P 173 0 R /K [10] /ActualText (vital capacity and 3.14% \(95%CI: 0.02%, 6.30%\) in forced expiratory volume in 1 ) /Type /StructElem /S /Span >> endobj 726 0 obj << /Pg 45 0 R /P 173 0 R /K [11] /ActualText (second. The findings were consistent with previous ) /Type /StructElem /S /Span >> endobj 727 0 obj << /Pg 45 0 R /P 173 0 R /K [12] /ActualText (chamber) /Type /StructElem /S /Span >> endobj 728 0 obj << /Pg 45 0 R /P 173 0 R /K [13] /ActualText ( ) /Type /StructElem /S /Span >> endobj 729 0 obj << /Pg 45 0 R /P 173 0 R /K [14] /ActualText (studies tha) /Type /StructElem /S /Span >> endobj 730 0 obj << /Pg 45 0 R /P 173 0 R /K [15] /ActualText (t) /Type /StructElem /S /Span >> endobj 731 0 obj << /Pg 45 0 R /P 173 0 R /K [16] /ActualText ( ) /Type /StructElem /S /Span >> endobj 732 0 obj << /Pg 45 0 R /P 173 0 R /K [17] /ActualText (revealed) /Type /StructElem /S /Span >> endobj 733 0 obj << /Pg 45 0 R /P 173 0 R /K [18] /ActualText ( ) /Type /StructElem /S /Span >> endobj 734 0 obj << /Pg 45 0 R /P 173 0 R /K [19] /ActualText (delayed impairment of l) /Type /StructElem /S /Span >> endobj 735 0 obj << /Pg 45 0 R /P 173 0 R /K [20] /ActualText (ung function ) /Type /StructElem /S /Span >> endobj 736 0 obj << /Pg 45 0 R /P 173 0 R /K [21] /ActualText (after acute ozone exposure) /Type /StructElem /S /Span >> endobj 737 0 obj << /Pg 45 0 R /P 173 0 R /K [22] /ActualText ( ) /Type /StructElem /S /Span >> endobj 738 0 obj << /Pg 45 0 R /P 173 0 R /K [23] /ActualText ([) /Type /StructElem /S /Span >> endobj 99 0 obj << /Pg 45 0 R /P 173 0 R /K [844 0 R 744 0 R] /Type /StructElem /S /Link >> endobj 844 0 obj << /Pg 45 0 R /Obj 48 0 R /Type /OBJR >> endobj 744 0 obj << /Pg 45 0 R /P 99 0 R /K [24] /ActualText (6) /Type /StructElem /S /Span >> endobj 739 0 obj << /Pg 45 0 R /P 173 0 R /K [25] /ActualText (, ) /Type /StructElem /S /Span >> endobj 100 0 obj << /Pg 45 0 R /P 173 0 R /K [845 0 R 745 0 R] /Type /StructElem /S /Link >> endobj 845 0 obj << /Pg 45 0 R /Obj 49 0 R /Type /OBJR >> endobj 745 0 obj << /Pg 45 0 R /P 100 0 R /K [26] /ActualText (7) /Type /StructElem /S /Span >> endobj 740 0 obj << /Pg 45 0 R /P 173 0 R /K [27] /ActualText (]) /Type /StructElem /S /Span >> endobj 741 0 obj << /Pg 45 0 R /P 173 0 R /K [28] /ActualText (.) /Type /StructElem /S /Span >> endobj 742 0 obj << /Pg 45 0 R /P 173 0 R /K [29] /ActualText ( ) /Type /StructElem /S /Span >> endobj 743 0 obj << /Pg 45 0 R /P 173 0 R /K [30] /ActualText ( ) /Type /StructElem /S /Span >> endobj 174 0 obj << /Pg 45 0 R /P 81 0 R /K [746 0 R 747 0 R 748 0 R 749 0 R 750 0 R 751 0 R 752 0 R 753 0 R 754 0 R 755 0 R 756 0 R 757 0 R 758 0 R 759 0 R 101 0 R 761 0 R 762 0 R 763 0 R 764 0 R 765 0 R 766 0 R 767 0 R 768 0 R 769 0 R 770 0 R 771 0 R 772 0 R 773 0 R 774 0 R 775 0 R 776 0 R 777 0 R 778 0 R 779 0 R 780 0 R 781 0 R 782 0 R 783 0 R 784 0 R 785 0 R 786 0 R 787 0 R 788 0 R 789 0 R 790 0 R 791 0 R 792 0 R] /Type /StructElem /S /P >> endobj 746 0 obj << /Pg 45 0 R /P 174 0 R /K [31] /ActualText (Impaired l) /Type /StructElem /S /Span >> endobj 747 0 obj << /Pg 45 0 R /P 174 0 R /K [32] /ActualText (ung function) /Type /StructElem /S /Span >> endobj 748 0 obj << /Pg 45 0 R /P 174 0 R /K [33] /ActualText ( ) /Type /StructElem /S /Span >> endobj 749 0 obj << /Pg 45 0 R /P 174 0 R /K [34] /ActualText (was always accompanied by ) /Type /StructElem /S /Span >> endobj 750 0 obj << /Pg 45 0 R /P 174 0 R /K [35] /ActualText (increase) /Type /StructElem /S /Span >> endobj 751 0 obj << /Pg 45 0 R /P 174 0 R /K [36] /ActualText (d) /Type /StructElem /S /Span >> endobj 752 0 obj << /Pg 45 0 R /P 174 0 R /K [37] /ActualText ( ) /Type /StructElem /S /Span >> endobj 753 0 obj << /Pg 45 0 R /P 174 0 R /K [38] /ActualText (epitheli) /Type /StructElem /S /Span >> endobj 754 0 obj << /Pg 45 0 R /P 174 0 R /K [39] /ActualText (al) /Type /StructElem /S /Span >> endobj 755 0 obj << /Pg 45 0 R /P 174 0 R /K [40] /ActualText ( ) /Type /StructElem /S /Span >> endobj 756 0 obj << /Pg 45 0 R /P 174 0 R /K [41] /ActualText (permeability) /Type /StructElem /S /Span >> endobj 757 0 obj << /Pg 45 0 R /P 174 0 R /K [42] /ActualText (, which can be indicated by elevated serum levels of CC16) /Type /StructElem /S /Span >> endobj 758 0 obj << /Pg 45 0 R /P 174 0 R /K [43] /ActualText ( ) /Type /StructElem /S /Span >> endobj 759 0 obj << /Pg 45 0 R /P 174 0 R /K [44] /ActualText ([) /Type /StructElem /S /Span >> endobj 101 0 obj << /Pg 45 0 R /P 174 0 R /K [846 0 R 760 0 R] /Type /StructElem /S /Link >> endobj 846 0 obj << /Pg 45 0 R /Obj 50 0 R /Type /OBJR >> endobj 760 0 obj << /Pg 45 0 R /P 101 0 R /K [45] /ActualText (4) /Type /StructElem /S /Span >> endobj 761 0 obj << /Pg 45 0 R /P 174 0 R /K [46] /ActualText (]) /Type /StructElem /S /Span >> endobj 762 0 obj << /Pg 45 0 R /P 174 0 R /K [47] /ActualText (. ) /Type /StructElem /S /Span >> endobj 763 0 obj << /Pg 45 0 R /P 174 0 R /K [48] /ActualText (Similarly, ) /Type /StructElem /S /Span >> endobj 764 0 obj << /Pg 45 0 R /P 174 0 R /K [49] /ActualText (we found serum CC16 increased by 41.93 % \(95% CI: 31.96%, 51.89%\) 2 hours after ) /Type /StructElem /S /Span >> endobj 765 0 obj << /Pg 45 0 R /P 174 0 R /K [50] /ActualText (exposure to ozone compared with filtered air, and then the effect attenuated ) /Type /StructElem /S /Span >> endobj 766 0 obj << /Pg 45 0 R /P 174 0 R /K [51] /ActualText (considerably but remained significant at lag 15 h. ) /Type /StructElem /S /Span >> endobj 767 0 obj << /Pg 45 0 R /P 174 0 R /K [52] /ActualText (Elevat) /Type /StructElem /S /Span >> endobj 768 0 obj << /Pg 45 0 R /P 174 0 R /K [53] /ActualText (ed ) /Type /StructElem /S /Span >> endobj 769 0 obj << /Pg 45 0 R /P 174 0 R /K [54] /ActualText (serum CC16 ) /Type /StructElem /S /Span >> endobj 770 0 obj << /Pg 45 0 R /P 174 0 R /K [55] /ActualText (levels ) /Type /StructElem /S /Span >> endobj 771 0 obj << /Pg 45 0 R /P 174 0 R /K [56] /ActualText (at lag 2 ) /Type /StructElem /S /Span >> endobj 772 0 obj << /Pg 45 0 R /P 174 0 R /K [57] /ActualText (h) /Type /StructElem /S /Span >> endobj 773 0 obj << /Pg 45 0 R /P 174 0 R /K [58] /ActualText ( ) /Type /StructElem /S /Span >> endobj 774 0 obj << /Pg 45 0 R /P 174 0 R /K [59] /ActualText (was significantly correlated with ) /Type /StructElem /S /Span >> endobj 775 0 obj << /Pg 45 0 R /P 174 0 R /K [60] /ActualText (decrements ) /Type /StructElem /S /Span >> endobj 776 0 obj << /Pg 45 0 R /P 174 0 R /K [61] /ActualText (in ) /Type /StructElem /S /Span >> endobj 777 0 obj << /Pg 45 0 R /P 174 0 R /K [62] /ActualText (both FVC and FEV) /Type /StructElem /S /Span >> endobj 778 0 obj << /Pg 45 0 R /P 174 0 R /K [63] /ActualText (1) /Type /StructElem /S /Span >> endobj 779 0 obj << /Pg 45 0 R /P 174 0 R /K [64] /ActualText ( ) /Type /StructElem /S /Span >> endobj 780 0 obj << /Pg 45 0 R /P 174 0 R /K [65] /ActualText (at lag 15 h) /Type /StructElem /S /Span >> endobj 781 0 obj << /Pg 45 0 R /P 174 0 R /K [66] /ActualText (, ) /Type /StructElem /S /Span >> endobj 782 0 obj << /Pg 45 0 R /P 174 0 R /K [67] /ActualText (suggesting a potential temporal pattern) /Type /StructElem /S /Span >> endobj 783 0 obj << /Pg 45 0 R /P 174 0 R /K [68] /ActualText ( ) /Type /StructElem /S /Span >> endobj 784 0 obj << /Pg 45 0 R /P 174 0 R /K [69] /ActualText ( ) /Type /StructElem /S /Span >> endobj 785 0 obj << /Pg 45 0 R /P 174 0 R /K [70] /ActualText ( ) /Type /StructElem /S /Span >> endobj 786 0 obj << /Pg 45 0 R /P 174 0 R /K [71] /ActualText (from ozone exposure, increased epithelial ) /Type /StructElem /S /Span >> endobj 787 0 obj << /Pg 45 0 R /P 174 0 R /K [72] /ActualText (permeability to) /Type /StructElem /S /Span >> endobj 788 0 obj << /Pg 45 0 R /P 174 0 R /K [73] /ActualText ( ) /Type /StructElem /S /Span >> endobj 789 0 obj << /Pg 45 0 R /P 174 0 R /K [74] /ActualText (impaired) /Type /StructElem /S /Span >> endobj 790 0 obj << /Pg 45 0 R /P 174 0 R /K [75] /ActualText ( ) /Type /StructElem /S /Span >> endobj 791 0 obj << /Pg 45 0 R /P 174 0 R /K [76] /ActualText (lung function.) /Type /StructElem /S /Span >> endobj 792 0 obj << /Pg 45 0 R /P 174 0 R /K [77] /ActualText ( ) /Type /StructElem /S /Span >> endobj 175 0 obj << /Pg 45 0 R /P 81 0 R /K [793 0 R 794 0 R 795 0 R 796 0 R 797 0 R 798 0 R 799 0 R 800 0 R 801 0 R 802 0 R 803 0 R 804 0 R 805 0 R 806 0 R 807 0 R 808 0 R 809 0 R 810 0 R 811 0 R 812 0 R 813 0 R 814 0 R 815 0 R 816 0 R 817 0 R 818 0 R 819 0 R 820 0 R 821 0 R 822 0 R 823 0 R 824 0 R 825 0 R 826 0 R 827 0 R 828 0 R 829 0 R 830 0 R 831 0 R 832 0 R 833 0 R 834 0 R 835 0 R 836 0 R 837 0 R 838 0 R 102 0 R 840 0 R 841 0 R 842 0 R 843 0 R] /Type /StructElem /S /P >> endobj 793 0 obj << /Pg 45 0 R /P 175 0 R /K [78] /ActualText (N) /Type /StructElem /S /Span >> endobj 794 0 obj << /Pg 45 0 R /P 175 0 R /K [79] /ActualText (ot) /Type /StructElem /S /Span >> endobj 795 0 obj << /Pg 45 0 R /P 175 0 R /K [80] /ActualText (ably) /Type /StructElem /S /Span >> endobj 796 0 obj << /Pg 45 0 R /P 175 0 R /K [81] /ActualText (,) /Type /StructElem /S /Span >> endobj 797 0 obj << /Pg 45 0 R /P 175 0 R /K [82] /ActualText ( ) /Type /StructElem /S /Span >> endobj 798 0 obj << /Pg 45 0 R /P 175 0 R /K [83] /ActualText (we ) /Type /StructElem /S /Span >> endobj 799 0 obj << /Pg 45 0 R /P 175 0 R /K [84] /ActualText (presented, to our knowledge for the first time, the human) /Type /StructElem /S /Span >> endobj 800 0 obj << /Pg 45 0 R /P 175 0 R /K [85] /ActualText (-) /Type /StructElem /S /Span >> endobj 801 0 obj << /Pg 45 0 R /P 175 0 R /K [86] /ActualText (based ) /Type /StructElem /S /Span >> endobj 802 0 obj << /Pg 45 0 R /P 175 0 R /K [87] /ActualText (evidence ) /Type /StructElem /S /Span >> endobj 803 0 obj << /Pg 45 0 R /P 175 0 R /K [88] /ActualText (that short) /Type /StructElem /S /Span >> endobj 804 0 obj << /Pg 45 0 R /P 175 0 R /K [89] /ActualText (-) /Type /StructElem /S /Span >> endobj 805 0 obj << /Pg 45 0 R /P 175 0 R /K [90] /ActualText (term ozone exposure could ) /Type /StructElem /S /Span >> endobj 806 0 obj << /Pg 45 0 R /P 175 0 R /K [91] /ActualText (significantly decrease the diversity) /Type /StructElem /S /Span >> endobj 807 0 obj << /Pg 45 0 R /P 175 0 R /K [92] /ActualText ( ) /Type /StructElem /S /Span >> endobj 808 0 obj << /Pg 45 0 R /P 175 0 R /K [93] /ActualText (of ) /Type /StructElem /S /Span >> endobj 809 0 obj << /Pg 45 0 R /P 175 0 R /K [94] /ActualText (nasal bacterial community) /Type /StructElem /S /Span >> endobj 810 0 obj << /Pg 45 0 R /P 175 0 R /K [95] /ActualText (.) /Type /StructElem /S /Span >> endobj 811 0 obj << /Pg 45 0 R /P 175 0 R /K [96] /ActualText ( ) /Type /StructElem /S /Span >> endobj 812 0 obj << /Pg 45 0 R /P 175 0 R /K [97] /ActualText (As shown in Figure 1a, ACE, Simpson and Shannon were ) /Type /StructElem /S /Span >> endobj 813 0 obj << /Pg 45 0 R /P 175 0 R /K [98] /ActualText (significantly lower in the ozone group than in the filtered air group, suggesting distinct ) /Type /StructElem /S /Span >> endobj 814 0 obj << /Pg 45 0 R /P 175 0 R /K [99] /ActualText (reductions in both nasal bacterial community richness and evenness after ozone ) /Type /StructElem /S /Span >> endobj 815 0 obj << /Pg 45 0 R /P 175 0 R /K [100] /ActualText (inhalation) /Type /StructElem /S /Span >> endobj 816 0 obj << /Pg 45 0 R /P 175 0 R /K [101] /ActualText (. Meanwhile, we observe) /Type /StructElem /S /Span >> endobj 817 0 obj << /Pg 45 0 R /P 175 0 R /K [102] /ActualText (d a clear separation between ) /Type /StructElem /S /Span >> endobj 818 0 obj << /Pg 45 0 R /P 175 0 R /K [103] /ActualText (the ozone ) /Type /StructElem /S /Span >> endobj 819 0 obj << /Pg 45 0 R /P 175 0 R /K [104] /ActualText (groups) /Type /StructElem /S /Span >> endobj 820 0 obj << /Pg 45 0 R /P 175 0 R /K [105] /ActualText ( ) /Type /StructElem /S /Span >> endobj 821 0 obj << /Pg 45 0 R /P 175 0 R /K [106] /ActualText (and ) /Type /StructElem /S /Span >> endobj 822 0 obj << /Pg 45 0 R /P 175 0 R /K [107] /ActualText (the filtered air group) /Type /StructElem /S /Span >> endobj 823 0 obj << /Pg 45 0 R /P 175 0 R /K [108] /ActualText ( ) /Type /StructElem /S /Span >> endobj 824 0 obj << /Pg 45 0 R /P 175 0 R /K [109] /ActualText (in the Figure 1b \(p = 0.007\)) /Type /StructElem /S /Span >> endobj 825 0 obj << /Pg 45 0 R /P 175 0 R /K [110] /ActualText (, ) /Type /StructElem /S /Span >> endobj 826 0 obj << /Pg 45 0 R /P 175 0 R /K [111] /ActualText (indicating an evident difference in ) /Type /StructElem /S /Span >> endobj 827 0 obj << /Pg 45 0 R /P 175 0 R /K [112] /ActualText (nasal bacterial community between groups) /Type /StructElem /S /Span >> endobj 828 0 obj << /Pg 45 0 R /P 175 0 R /K [113] /ActualText (. ) /Type /StructElem /S /Span >> endobj 829 0 obj << /Pg 45 0 R /P 175 0 R /K [114] /ActualText (Some ) /Type /StructElem /S /Span >> endobj 830 0 obj << /Pg 45 0 R /P 175 0 R /K [115] /ActualText (in vitro) /Type /StructElem /S /Span >> endobj 831 0 obj << /Pg 45 0 R /P 175 0 R /K [116] /ActualText ( ) /Type /StructElem /S /Span >> endobj 832 0 obj << /Pg 45 0 R /P 175 0 R /K [117] /ActualText (studies ) /Type /StructElem /S /Span >> endobj 833 0 obj << /Pg 45 0 R /P 175 0 R /K [118] /ActualText (also ) /Type /StructElem /S /Span >> endobj 834 0 obj << /Pg 45 0 R /P 175 0 R /K [119] /ActualText (demonstrated ) /Type /StructElem /S /Span >> endobj 835 0 obj << /Pg 45 0 R /P 175 0 R /K [120] /ActualText (the anti) /Type /StructElem /S /Span >> endobj 836 0 obj << /Pg 45 0 R /P 175 0 R /K [121] /ActualText (-) /Type /StructElem /S /Span >> endobj 837 0 obj << /Pg 45 0 R /P 175 0 R /K [122] /ActualText (microbial potential of ozone ) /Type /StructElem /S /Span >> endobj 838 0 obj << /Pg 45 0 R /P 175 0 R /K [123] /ActualText ([) /Type /StructElem /S /Span >> endobj 102 0 obj << /Pg 45 0 R /P 175 0 R /K [847 0 R 839 0 R] /Type /StructElem /S /Link >> endobj 847 0 obj << /Pg 45 0 R /Obj 51 0 R /Type /OBJR >> endobj 839 0 obj << /Pg 45 0 R /P 102 0 R /K [124] /ActualText (11) /Type /StructElem /S /Span >> endobj 840 0 obj << /Pg 45 0 R /P 175 0 R /K [125] /ActualText (]) /Type /StructElem /S /Span >> endobj 841 0 obj << /Pg 45 0 R /P 175 0 R /K [126] /ActualText (.) /Type /StructElem /S /Span >> endobj 842 0 obj << /Pg 45 0 R /P 175 0 R /K [127] /ActualText ( ) /Type /StructElem /S /Span >> endobj 843 0 obj << /Pg 45 0 R /P 175 0 R /K [128] /ActualText (Diminished diversity of bacterial community ) /Type /StructElem /S /Span >> endobj 176 0 obj << /Pg 52 0 R /P 81 0 R /K [848 0 R 849 0 R 850 0 R 851 0 R 852 0 R 853 0 R 104 0 R 854 0 R 105 0 R 855 0 R 856 0 R 857 0 R 858 0 R 859 0 R 860 0 R 861 0 R 862 0 R 863 0 R 864 0 R 865 0 R 866 0 R 867 0 R 868 0 R 869 0 R 870 0 R 871 0 R 872 0 R 873 0 R 874 0 R 875 0 R 876 0 R 877 0 R 878 0 R 879 0 R 880 0 R 881 0 R 882 0 R 883 0 R 884 0 R 885 0 R 886 0 R 887 0 R 888 0 R 889 0 R 890 0 R 891 0 R 892 0 R 893 0 R 894 0 R 895 0 R 896 0 R 897 0 R 898 0 R 899 0 R 900 0 R 901 0 R 902 0 R 903 0 R 904 0 R 905 0 R 906 0 R 907 0 R 908 0 R 909 0 R 910 0 R 106 0 R 911 0 R 912 0 R 913 0 R 914 0 R 915 0 R 916 0 R 917 0 R 918 0 R 919 0 R 920 0 R 921 0 R 922 0 R 923 0 R 924 0 R 925 0 R 926 0 R 927 0 R 928 0 R 929 0 R 930 0 R 931 0 R 932 0 R 933 0 R 934 0 R 935 0 R 936 0 R 937 0 R 938 0 R 107 0 R 939 0 R 940 0 R 941 0 R 942 0 R 943 0 R 944 0 R 945 0 R 946 0 R 947 0 R 948 0 R 949 0 R 950 0 R 951 0 R 952 0 R 953 0 R 954 0 R 955 0 R 956 0 R 957 0 R 958 0 R 959 0 R 960 0 R 961 0 R 962 0 R 963 0 R] /Type /StructElem /S /P >> endobj 848 0 obj << /Pg 52 0 R /P 176 0 R /K [0] /ActualText (in upper respiratory tract have been associated with several respir) /Type /StructElem /S /Span >> endobj 103 0 obj [848 0 R 849 0 R 850 0 R 851 0 R 852 0 R 853 0 R 964 0 R 854 0 R 965 0 R 855 0 R 856 0 R 857 0 R 858 0 R 859 0 R 860 0 R 861 0 R 862 0 R 863 0 R 864 0 R 865 0 R 866 0 R 867 0 R 868 0 R 869 0 R 870 0 R 871 0 R 872 0 R 873 0 R 874 0 R 875 0 R 876 0 R 877 0 R 878 0 R 879 0 R 880 0 R 881 0 R 882 0 R 883 0 R 884 0 R 885 0 R 886 0 R 887 0 R 888 0 R 889 0 R 890 0 R 891 0 R 892 0 R 893 0 R 894 0 R 895 0 R 896 0 R 897 0 R 898 0 R 899 0 R 900 0 R 901 0 R 902 0 R 903 0 R 904 0 R 905 0 R 906 0 R 907 0 R 908 0 R 909 0 R 910 0 R 966 0 R 911 0 R 912 0 R 913 0 R 914 0 R 915 0 R 916 0 R 917 0 R 918 0 R 919 0 R 920 0 R 921 0 R 922 0 R 923 0 R 924 0 R 925 0 R 926 0 R 927 0 R 928 0 R 929 0 R 930 0 R 931 0 R 932 0 R 933 0 R 934 0 R 935 0 R 936 0 R 937 0 R 938 0 R 967 0 R 939 0 R 940 0 R 941 0 R 942 0 R 943 0 R 944 0 R 945 0 R 946 0 R 947 0 R 948 0 R 949 0 R 950 0 R 951 0 R 952 0 R 953 0 R 954 0 R 955 0 R 956 0 R 957 0 R 958 0 R 959 0 R 960 0 R 961 0 R 962 0 R 963 0 R 968 0 R 969 0 R 970 0 R 971 0 R 972 0 R 973 0 R 974 0 R 975 0 R 976 0 R 977 0 R 978 0 R 979 0 R 980 0 R 981 0 R 982 0 R 983 0 R 984 0 R 985 0 R 986 0 R 987 0 R 988 0 R 989 0 R 990 0 R 991 0 R 992 0 R 993 0 R 994 0 R 995 0 R 996 0 R 997 0 R 998 0 R 999 0 R 1000 0 R 1001 0 R 1002 0 R 1003 0 R 1004 0 R 1005 0 R 1006 0 R 1007 0 R 1008 0 R 1009 0 R 1010 0 R 1011 0 R 1012 0 R 1013 0 R 1014 0 R 1015 0 R 1016 0 R 1017 0 R 1018 0 R 1019 0 R 1020 0 R 1021 0 R 1022 0 R 1023 0 R 1024 0 R 1025 0 R 1026 0 R 1027 0 R 1028 0 R 1029 0 R 1030 0 R 1031 0 R 1032 0 R 1033 0 R 1034 0 R] endobj 849 0 obj << /Pg 52 0 R /P 176 0 R /K [1] /ActualText (atory infectious ) /Type /StructElem /S /Span >> endobj 850 0 obj << /Pg 52 0 R /P 176 0 R /K [2] /ActualText (diseases in ) /Type /StructElem /S /Span >> endobj 851 0 obj << /Pg 52 0 R /P 176 0 R /K [3] /ActualText (clinical ) /Type /StructElem /S /Span >> endobj 852 0 obj << /Pg 52 0 R /P 176 0 R /K [4] /ActualText (studies ) /Type /StructElem /S /Span >> endobj 853 0 obj << /Pg 52 0 R /P 176 0 R /K [5] /ActualText ([) /Type /StructElem /S /Span >> endobj 104 0 obj << /Pg 52 0 R /P 176 0 R /K [1035 0 R 964 0 R] /Type /StructElem /S /Link >> endobj 1035 0 obj << /Pg 52 0 R /Obj 54 0 R /Type /OBJR >> endobj 964 0 obj << /Pg 52 0 R /P 104 0 R /K [6] /ActualText (12) /Type /StructElem /S /Span >> endobj 854 0 obj << /Pg 52 0 R /P 176 0 R /K [7] /ActualText (, ) /Type /StructElem /S /Span >> endobj 105 0 obj << /Pg 52 0 R /P 176 0 R /K [1036 0 R 965 0 R] /Type /StructElem /S /Link >> endobj 1036 0 obj << /Pg 52 0 R /Obj 55 0 R /Type /OBJR >> endobj 965 0 obj << /Pg 52 0 R /P 105 0 R /K [8] /ActualText (13) /Type /StructElem /S /Span >> endobj 855 0 obj << /Pg 52 0 R /P 176 0 R /K [9] /ActualText (]) /Type /StructElem /S /Span >> endobj 856 0 obj << /Pg 52 0 R /P 176 0 R /K [10] /ActualText (.) /Type /StructElem /S /Span >> endobj 857 0 obj << /Pg 52 0 R /P 176 0 R /K [11] /ActualText ( ) /Type /StructElem /S /Span >> endobj 858 0 obj << /Pg 52 0 R /P 176 0 R /K [12] /ActualText (In addition) /Type /StructElem /S /Span >> endobj 859 0 obj << /Pg 52 0 R /P 176 0 R /K [13] /ActualText (, ) /Type /StructElem /S /Span >> endobj 860 0 obj << /Pg 52 0 R /P 176 0 R /K [14] /ActualText (we found ) /Type /StructElem /S /Span >> endobj 861 0 obj << /Pg 52 0 R /P 176 0 R /K [15] /ActualText (the composition of ) /Type /StructElem /S /Span >> endobj 862 0 obj << /Pg 52 0 R /P 176 0 R /K [16] /ActualText (the ) /Type /StructElem /S /Span >> endobj 863 0 obj << /Pg 52 0 R /P 176 0 R /K [17] /ActualText (nasal ) /Type /StructElem /S /Span >> endobj 864 0 obj << /Pg 52 0 R /P 176 0 R /K [18] /ActualText (bacterial communit) /Type /StructElem /S /Span >> endobj 865 0 obj << /Pg 52 0 R /P 176 0 R /K [19] /ActualText (y) /Type /StructElem /S /Span >> endobj 866 0 obj << /Pg 52 0 R /P 176 0 R /K [20] /ActualText ( ) /Type /StructElem /S /Span >> endobj 867 0 obj << /Pg 52 0 R /P 176 0 R /K [21] /ActualText (was altered) /Type /StructElem /S /Span >> endobj 868 0 obj << /Pg 52 0 R /P 176 0 R /K [22] /ActualText ( ) /Type /StructElem /S /Span >> endobj 869 0 obj << /Pg 52 0 R /P 176 0 R /K [23] /ActualText (by ozone inhalation) /Type /StructElem /S /Span >> endobj 870 0 obj << /Pg 52 0 R /P 176 0 R /K [24] /ActualText (.) /Type /StructElem /S /Span >> endobj 871 0 obj << /Pg 52 0 R /P 176 0 R /K [25] /ActualText ( ) /Type /StructElem /S /Span >> endobj 872 0 obj << /Pg 52 0 R /P 176 0 R /K [26] /ActualText (Specifically) /Type /StructElem /S /Span >> endobj 873 0 obj << /Pg 52 0 R /P 176 0 R /K [27] /ActualText (, we observed ) /Type /StructElem /S /Span >> endobj 874 0 obj << /Pg 52 0 R /P 176 0 R /K [28] /ActualText (significant decrements in the relative abundance of ) /Type /StructElem /S /Span >> endobj 875 0 obj << /Pg 52 0 R /P 176 0 R /K [29] /ActualText (2 phyla) /Type /StructElem /S /Span >> endobj 876 0 obj << /Pg 52 0 R /P 176 0 R /K [30] /ActualText ( ) /Type /StructElem /S /Span >> endobj 877 0 obj << /Pg 52 0 R /P 176 0 R /K [31] /ActualText (Actinobacteria) /Type /StructElem /S /Span >> endobj 878 0 obj << /Pg 52 0 R /P 176 0 R /K [32] /ActualText ( ) /Type /StructElem /S /Span >> endobj 879 0 obj << /Pg 52 0 R /P 176 0 R /K [33] /ActualText (and ) /Type /StructElem /S /Span >> endobj 880 0 obj << /Pg 52 0 R /P 176 0 R /K [34] /ActualText (Firmicutes) /Type /StructElem /S /Span >> endobj 881 0 obj << /Pg 52 0 R /P 176 0 R /K [35] /ActualText ( ) /Type /StructElem /S /Span >> endobj 882 0 obj << /Pg 52 0 R /P 176 0 R /K [36] /ActualText (\(see Figure 1c\)) /Type /StructElem /S /Span >> endobj 883 0 obj << /Pg 52 0 R /P 176 0 R /K [37] /ActualText (, also known as ) /Type /StructElem /S /Span >> endobj 884 0 obj << /Pg 52 0 R /P 176 0 R /K [38] /ActualText (harmless commensal bacteria) /Type /StructElem /S /Span >> endobj 885 0 obj << /Pg 52 0 R /P 176 0 R /K [39] /ActualText ( ) /Type /StructElem /S /Span >> endobj 886 0 obj << /Pg 52 0 R /P 176 0 R /K [40] /ActualText (in nasal ) /Type /StructElem /S /Span >> endobj 887 0 obj << /Pg 52 0 R /P 176 0 R /K [41] /ActualText (capacity) /Type /StructElem /S /Span >> endobj 888 0 obj << /Pg 52 0 R /P 176 0 R /K [42] /ActualText (. The deceases in ) /Type /StructElem /S /Span >> endobj 889 0 obj << /Pg 52 0 R /P 176 0 R /K [43] /ActualText (the two ) /Type /StructElem /S /Span >> endobj 890 0 obj << /Pg 52 0 R /P 176 0 R /K [44] /ActualText (commensal bacteria) /Type /StructElem /S /Span >> endobj 891 0 obj << /Pg 52 0 R /P 176 0 R /K [45] /ActualText ( ) /Type /StructElem /S /Span >> endobj 892 0 obj << /Pg 52 0 R /P 176 0 R /K [46] /ActualText (may ) /Type /StructElem /S /Span >> endobj 893 0 obj << /Pg 52 0 R /P 176 0 R /K [47] /ActualText (result in d) /Type /StructElem /S /Span >> endobj 894 0 obj << /Pg 52 0 R /P 176 0 R /K [48] /ActualText (iminished) /Type /StructElem /S /Span >> endobj 895 0 obj << /Pg 52 0 R /P 176 0 R /K [49] /ActualText ( ) /Type /StructElem /S /Span >> endobj 896 0 obj << /Pg 52 0 R /P 176 0 R /K [50] /ActualText (resistance against ) /Type /StructElem /S /Span >> endobj 897 0 obj << /Pg 52 0 R /P 176 0 R /K [51] /ActualText (the colonization of ) /Type /StructElem /S /Span >> endobj 898 0 obj << /Pg 52 0 R /P 176 0 R /K [52] /ActualText (foreign) /Type /StructElem /S /Span >> endobj 899 0 obj << /Pg 52 0 R /P 176 0 R /K [53] /ActualText ( ) /Type /StructElem /S /Span >> endobj 900 0 obj << /Pg 52 0 R /P 176 0 R /K [54] /ActualText (pathogens) /Type /StructElem /S /Span >> endobj 901 0 obj << /Pg 52 0 R /P 176 0 R /K [55] /ActualText (, and thus increas) /Type /StructElem /S /Span >> endobj 902 0 obj << /Pg 52 0 R /P 176 0 R /K [56] /ActualText (e) /Type /StructElem /S /Span >> endobj 903 0 obj << /Pg 52 0 R /P 176 0 R /K [57] /ActualText ( ) /Type /StructElem /S /Span >> endobj 904 0 obj << /Pg 52 0 R /P 176 0 R /K [58] /ActualText (risk) /Type /StructElem /S /Span >> endobj 905 0 obj << /Pg 52 0 R /P 176 0 R /K [59] /ActualText (s) /Type /StructElem /S /Span >> endobj 906 0 obj << /Pg 52 0 R /P 176 0 R /K [60] /ActualText ( ) /Type /StructElem /S /Span >> endobj 907 0 obj << /Pg 52 0 R /P 176 0 R /K [61] /ActualText (of ) /Type /StructElem /S /Span >> endobj 908 0 obj << /Pg 52 0 R /P 176 0 R /K [62] /ActualText (bacterial or viral infection in the respiratory system) /Type /StructElem /S /Span >> endobj 909 0 obj << /Pg 52 0 R /P 176 0 R /K [63] /ActualText ( ) /Type /StructElem /S /Span >> endobj 910 0 obj << /Pg 52 0 R /P 176 0 R /K [64] /ActualText ([) /Type /StructElem /S /Span >> endobj 106 0 obj << /Pg 52 0 R /P 176 0 R /K [1037 0 R 966 0 R] /Type /StructElem /S /Link >> endobj 1037 0 obj << /Pg 52 0 R /Obj 56 0 R /Type /OBJR >> endobj 966 0 obj << /Pg 52 0 R /P 106 0 R /K [65] /ActualText (5) /Type /StructElem /S /Span >> endobj 911 0 obj << /Pg 52 0 R /P 176 0 R /K [66] /ActualText (]) /Type /StructElem /S /Span >> endobj 912 0 obj << /Pg 52 0 R /P 176 0 R /K [67] /ActualText (. ) /Type /StructElem /S /Span >> endobj 913 0 obj << /Pg 52 0 R /P 176 0 R /K [68] /ActualText (In ) /Type /StructElem /S /Span >> endobj 914 0 obj << /Pg 52 0 R /P 176 0 R /K [69] /ActualText (contrast, ) /Type /StructElem /S /Span >> endobj 915 0 obj << /Pg 52 0 R /P 176 0 R /K [70] /ActualText (a) /Type /StructElem /S /Span >> endobj 916 0 obj << /Pg 52 0 R /P 176 0 R /K [71] /ActualText (t) /Type /StructElem /S /Span >> endobj 917 0 obj << /Pg 52 0 R /P 176 0 R /K [72] /ActualText ( ) /Type /StructElem /S /Span >> endobj 918 0 obj << /Pg 52 0 R /P 176 0 R /K [73] /ActualText (the) /Type /StructElem /S /Span >> endobj 919 0 obj << /Pg 52 0 R /P 176 0 R /K [74] /ActualText ( ) /Type /StructElem /S /Span >> endobj 920 0 obj << /Pg 52 0 R /P 176 0 R /K [75] /ActualText (famil) /Type /StructElem /S /Span >> endobj 921 0 obj << /Pg 52 0 R /P 176 0 R /K [76] /ActualText (y level,) /Type /StructElem /S /Span >> endobj 922 0 obj << /Pg 52 0 R /P 176 0 R /K [77] /ActualText ( ) /Type /StructElem /S /Span >> endobj 923 0 obj << /Pg 52 0 R /P 176 0 R /K [78] /ActualText (we observed an relative enrichment of ) /Type /StructElem /S /Span >> endobj 924 0 obj << /Pg 52 0 R /P 176 0 R /K [79] /ActualText (Moraxellaceae) /Type /StructElem /S /Span >> endobj 925 0 obj << /Pg 52 0 R /P 176 0 R /K [80] /ActualText ( ) /Type /StructElem /S /Span >> endobj 926 0 obj << /Pg 52 0 R /P 176 0 R /K [81] /ActualText (and ) /Type /StructElem /S /Span >> endobj 927 0 obj << /Pg 52 0 R /P 176 0 R /K [82] /ActualText (Pseudomonadaceae) /Type /StructElem /S /Span >> endobj 928 0 obj << /Pg 52 0 R /P 176 0 R /K [83] /ActualText ( ) /Type /StructElem /S /Span >> endobj 929 0 obj << /Pg 52 0 R /P 176 0 R /K [84] /ActualText (following ozone exposure) /Type /StructElem /S /Span >> endobj 930 0 obj << /Pg 52 0 R /P 176 0 R /K [85] /ActualText ( ) /Type /StructElem /S /Span >> endobj 931 0 obj << /Pg 52 0 R /P 176 0 R /K [86] /ActualText (\(see Figure 1c\)) /Type /StructElem /S /Span >> endobj 932 0 obj << /Pg 52 0 R /P 176 0 R /K [87] /ActualText (, which) /Type /StructElem /S /Span >> endobj 933 0 obj << /Pg 52 0 R /P 176 0 R /K [88] /ActualText ( ) /Type /StructElem /S /Span >> endobj 934 0 obj << /Pg 52 0 R /P 176 0 R /K [89] /ActualText (were often involved in ) /Type /StructElem /S /Span >> endobj 935 0 obj << /Pg 52 0 R /P 176 0 R /K [90] /ActualText (the ) /Type /StructElem /S /Span >> endobj 936 0 obj << /Pg 52 0 R /P 176 0 R /K [91] /ActualText (development of ) /Type /StructElem /S /Span >> endobj 937 0 obj << /Pg 52 0 R /P 176 0 R /K [92] /ActualText (pneumonia and other infectious diseases ) /Type /StructElem /S /Span >> endobj 938 0 obj << /Pg 52 0 R /P 176 0 R /K [93] /ActualText ([) /Type /StructElem /S /Span >> endobj 107 0 obj << /Pg 52 0 R /P 176 0 R /K [1038 0 R 967 0 R] /Type /StructElem /S /Link >> endobj 1038 0 obj << /Pg 52 0 R /Obj 57 0 R /Type /OBJR >> endobj 967 0 obj << /Pg 52 0 R /P 107 0 R /K [94] /ActualText (12) /Type /StructElem /S /Span >> endobj 939 0 obj << /Pg 52 0 R /P 176 0 R /K [95] /ActualText (]) /Type /StructElem /S /Span >> endobj 940 0 obj << /Pg 52 0 R /P 176 0 R /K [96] /ActualText (.) /Type /StructElem /S /Span >> endobj 941 0 obj << /Pg 52 0 R /P 176 0 R /K [97] /ActualText ( ) /Type /StructElem /S /Span >> endobj 942 0 obj << /Pg 52 0 R /P 176 0 R /K [98] /ActualText (Therefore) /Type /StructElem /S /Span >> endobj 943 0 obj << /Pg 52 0 R /P 176 0 R /K [99] /ActualText (, ) /Type /StructElem /S /Span >> endobj 944 0 obj << /Pg 52 0 R /P 176 0 R /K [100] /ActualText (it ) /Type /StructElem /S /Span >> endobj 945 0 obj << /Pg 52 0 R /P 176 0 R /K [101] /ActualText (is ) /Type /StructElem /S /Span >> endobj 946 0 obj << /Pg 52 0 R /P 176 0 R /K [102] /ActualText (reasonable to ) /Type /StructElem /S /Span >> endobj 947 0 obj << /Pg 52 0 R /P 176 0 R /K [103] /ActualText (assume ) /Type /StructElem /S /Span >> endobj 948 0 obj << /Pg 52 0 R /P 176 0 R /K [104] /ActualText (that ) /Type /StructElem /S /Span >> endobj 949 0 obj << /Pg 52 0 R /P 176 0 R /K [105] /ActualText (t) /Type /StructElem /S /Span >> endobj 950 0 obj << /Pg 52 0 R /P 176 0 R /K [106] /ActualText (he im) /Type /StructElem /S /Span >> endobj 951 0 obj << /Pg 52 0 R /P 176 0 R /K [107] /ActualText (balance between ) /Type /StructElem /S /Span >> endobj 952 0 obj << /Pg 52 0 R /P 176 0 R /K [108] /ActualText (commensal and pathogenic ) /Type /StructElem /S /Span >> endobj 953 0 obj << /Pg 52 0 R /P 176 0 R /K [109] /ActualText (bacteria) /Type /StructElem /S /Span >> endobj 954 0 obj << /Pg 52 0 R /P 176 0 R /K [110] /ActualText ( ) /Type /StructElem /S /Span >> endobj 955 0 obj << /Pg 52 0 R /P 176 0 R /K [111] /ActualText (in upper respiratory tract ) /Type /StructElem /S /Span >> endobj 956 0 obj << /Pg 52 0 R /P 176 0 R /K [112] /ActualText (induced by ozone exposure ) /Type /StructElem /S /Span >> endobj 957 0 obj << /Pg 52 0 R /P 176 0 R /K [113] /ActualText (may lead to ) /Type /StructElem /S /Span >> endobj 958 0 obj << /Pg 52 0 R /P 176 0 R /K [114] /ActualText (individual ) /Type /StructElem /S /Span >> endobj 959 0 obj << /Pg 52 0 R /P 176 0 R /K [115] /ActualText (vulnerability) /Type /StructElem /S /Span >> endobj 960 0 obj << /Pg 52 0 R /P 176 0 R /K [116] /ActualText ( ) /Type /StructElem /S /Span >> endobj 961 0 obj << /Pg 52 0 R /P 176 0 R /K [117] /ActualText (to respiratory infection) /Type /StructElem /S /Span >> endobj 962 0 obj << /Pg 52 0 R /P 176 0 R /K [118] /ActualText (.) /Type /StructElem /S /Span >> endobj 963 0 obj << /Pg 52 0 R /P 176 0 R /K [119] /ActualText ( ) /Type /StructElem /S /Span >> endobj 177 0 obj << /Pg 52 0 R /P 81 0 R /K [968 0 R 969 0 R 970 0 R 971 0 R 972 0 R 973 0 R 974 0 R 975 0 R 976 0 R 977 0 R 978 0 R 979 0 R 980 0 R 981 0 R 982 0 R 983 0 R 984 0 R 985 0 R 986 0 R 987 0 R 988 0 R 989 0 R 990 0 R 991 0 R 992 0 R 993 0 R 994 0 R 995 0 R 996 0 R 997 0 R 998 0 R 999 0 R 1000 0 R 1001 0 R 1002 0 R 1003 0 R 1004 0 R 1005 0 R 1006 0 R 1007 0 R 1008 0 R 1009 0 R 1010 0 R 1011 0 R 1012 0 R 1013 0 R 1014 0 R 1015 0 R 1016 0 R 1017 0 R 1018 0 R 1019 0 R 108 0 R 1021 0 R 1022 0 R 1023 0 R 1024 0 R 1025 0 R 1026 0 R 1027 0 R 1028 0 R 1029 0 R 1030 0 R 1031 0 R 1032 0 R 1033 0 R 1034 0 R] /Type /StructElem /S /P >> endobj 968 0 obj << /Pg 52 0 R /P 177 0 R /K [120] /ActualText (The colonization and proliferation of bacteria in ) /Type /StructElem /S /Span >> endobj 969 0 obj << /Pg 52 0 R /P 177 0 R /K [121] /ActualText (the ) /Type /StructElem /S /Span >> endobj 970 0 obj << /Pg 52 0 R /P 177 0 R /K [122] /ActualText (respiratory tract ) /Type /StructElem /S /Span >> endobj 971 0 obj << /Pg 52 0 R /P 177 0 R /K [123] /ActualText (may ) /Type /StructElem /S /Span >> endobj 972 0 obj << /Pg 52 0 R /P 177 0 R /K [124] /ActualText (also) /Type /StructElem /S /Span >> endobj 973 0 obj << /Pg 52 0 R /P 177 0 R /K [125] /ActualText ( ) /Type /StructElem /S /Span >> endobj 974 0 obj << /Pg 52 0 R /P 177 0 R /K [126] /ActualText (be) /Type /StructElem /S /Span >> endobj 975 0 obj << /Pg 52 0 R /P 177 0 R /K [127] /ActualText ( ) /Type /StructElem /S /Span >> endobj 976 0 obj << /Pg 52 0 R /P 177 0 R /K [128] /ActualText (influenced by) /Type /StructElem /S /Span >> endobj 977 0 obj << /Pg 52 0 R /P 177 0 R /K [129] /ActualText ( ) /Type /StructElem /S /Span >> endobj 978 0 obj << /Pg 52 0 R /P 177 0 R /K [130] /ActualText (some) /Type /StructElem /S /Span >> endobj 979 0 obj << /Pg 52 0 R /P 177 0 R /K [131] /ActualText ( ) /Type /StructElem /S /Span >> endobj 980 0 obj << /Pg 52 0 R /P 177 0 R /K [132] /ActualText (substance) /Type /StructElem /S /Span >> endobj 981 0 obj << /Pg 52 0 R /P 177 0 R /K [133] /ActualText (s) /Type /StructElem /S /Span >> endobj 982 0 obj << /Pg 52 0 R /P 177 0 R /K [134] /ActualText ( ) /Type /StructElem /S /Span >> endobj 983 0 obj << /Pg 52 0 R /P 177 0 R /K [135] /ActualText (in ) /Type /StructElem /S /Span >> endobj 984 0 obj << /Pg 52 0 R /P 177 0 R /K [136] /ActualText (airway surface liquid) /Type /StructElem /S /Span >> endobj 985 0 obj << /Pg 52 0 R /P 177 0 R /K [137] /ActualText (. ) /Type /StructElem /S /Span >> endobj 986 0 obj << /Pg 52 0 R /P 177 0 R /K [138] /ActualText (In ) /Type /StructElem /S /Span >> endobj 987 0 obj << /Pg 52 0 R /P 177 0 R /K [139] /ActualText (this metabolomic analysis) /Type /StructElem /S /Span >> endobj 988 0 obj << /Pg 52 0 R /P 177 0 R /K [140] /ActualText ( ) /Type /StructElem /S /Span >> endobj 989 0 obj << /Pg 52 0 R /P 177 0 R /K [141] /ActualText (with EBC) /Type /StructElem /S /Span >> endobj 990 0 obj << /Pg 52 0 R /P 177 0 R /K [142] /ActualText (, w) /Type /StructElem /S /Span >> endobj 991 0 obj << /Pg 52 0 R /P 177 0 R /K [143] /ActualText (e) /Type /StructElem /S /Span >> endobj 992 0 obj << /Pg 52 0 R /P 177 0 R /K [144] /ActualText ( ) /Type /StructElem /S /Span >> endobj 993 0 obj << /Pg 52 0 R /P 177 0 R /K [145] /ActualText (found ) /Type /StructElem /S /Span >> endobj 994 0 obj << /Pg 52 0 R /P 177 0 R /K [146] /ActualText (that) /Type /StructElem /S /Span >> endobj 995 0 obj << /Pg 52 0 R /P 177 0 R /K [147] /ActualText ( ) /Type /StructElem /S /Span >> endobj 996 0 obj << /Pg 52 0 R /P 177 0 R /K [148] /ActualText (glucose was significantly) /Type /StructElem /S /Span >> endobj 997 0 obj << /Pg 52 0 R /P 177 0 R /K [149] /ActualText ( ) /Type /StructElem /S /Span >> endobj 998 0 obj << /Pg 52 0 R /P 177 0 R /K [150] /ActualText (elevated) /Type /StructElem /S /Span >> endobj 999 0 obj << /Pg 52 0 R /P 177 0 R /K [151] /ActualText ( ) /Type /StructElem /S /Span >> endobj 1000 0 obj << /Pg 52 0 R /P 177 0 R /K [152] /ActualText (after ) /Type /StructElem /S /Span >> endobj 1001 0 obj << /Pg 52 0 R /P 177 0 R /K [153] /ActualText (an inhalation of ) /Type /StructElem /S /Span >> endobj 1002 0 obj << /Pg 52 0 R /P 177 0 R /K [154] /ActualText (ozone relative to filtered air with a fold change \(FC\) of 1.59, accompanied by ) /Type /StructElem /S /Span >> endobj 1003 0 obj << /Pg 52 0 R /P 177 0 R /K [155] /ActualText (significantly increased D) /Type /StructElem /S /Span >> endobj 1004 0 obj << /Pg 52 0 R /P 177 0 R /K [156] /ActualText (-) /Type /StructElem /S /Span >> endobj 1005 0 obj << /Pg 52 0 R /P 177 0 R /K [157] /ActualText (glyceric acid \(FC=1.27\) and lactic acid \(FC=1.15\). The ) /Type /StructElem /S /Span >> endobj 1006 0 obj << /Pg 52 0 R /P 177 0 R /K [158] /ActualText (alteration ) /Type /StructElem /S /Span >> endobj 1007 0 obj << /Pg 52 0 R /P 177 0 R /K [159] /ActualText (of) /Type /StructElem /S /Span >> endobj 1008 0 obj << /Pg 52 0 R /P 177 0 R /K [160] /ActualText ( ) /Type /StructElem /S /Span >> endobj 1009 0 obj << /Pg 52 0 R /P 177 0 R /K [161] /ActualText (airway ) /Type /StructElem /S /Span >> endobj 1010 0 obj << /Pg 52 0 R /P 177 0 R /K [162] /ActualText (glucose metabolism ) /Type /StructElem /S /Span >> endobj 1011 0 obj << /Pg 52 0 R /P 177 0 R /K [163] /ActualText (by ozone ) /Type /StructElem /S /Span >> endobj 1012 0 obj << /Pg 52 0 R /P 177 0 R /K [164] /ActualText (was) /Type /StructElem /S /Span >> endobj 1013 0 obj << /Pg 52 0 R /P 177 0 R /K [165] /ActualText ( ) /Type /StructElem /S /Span >> endobj 1014 0 obj << /Pg 52 0 R /P 177 0 R /K [166] /ActualText (in accordance with ) /Type /StructElem /S /Span >> endobj 1015 0 obj << /Pg 52 0 R /P 177 0 R /K [167] /ActualText (a ) /Type /StructElem /S /Span >> endobj 1016 0 obj << /Pg 52 0 R /P 177 0 R /K [168] /ActualText (previous ) /Type /StructElem /S /Span >> endobj 1017 0 obj << /Pg 52 0 R /P 177 0 R /K [169] /ActualText (study) /Type /StructElem /S /Span >> endobj 1018 0 obj << /Pg 52 0 R /P 177 0 R /K [170] /ActualText ( ) /Type /StructElem /S /Span >> endobj 1019 0 obj << /Pg 52 0 R /P 177 0 R /K [171] /ActualText ([) /Type /StructElem /S /Span >> endobj 108 0 obj << /Pg 52 0 R /P 177 0 R /K [1039 0 R 1020 0 R] /Type /StructElem /S /Link >> endobj 1039 0 obj << /Pg 52 0 R /Obj 58 0 R /Type /OBJR >> endobj 1020 0 obj << /Pg 52 0 R /P 108 0 R /K [172] /ActualText (8) /Type /StructElem /S /Span >> endobj 1021 0 obj << /Pg 52 0 R /P 177 0 R /K [173] /ActualText (]) /Type /StructElem /S /Span >> endobj 1022 0 obj << /Pg 52 0 R /P 177 0 R /K [174] /ActualText (. ) /Type /StructElem /S /Span >> endobj 1023 0 obj << /Pg 52 0 R /P 177 0 R /K [175] /ActualText (Increased ) /Type /StructElem /S /Span >> endobj 1024 0 obj << /Pg 52 0 R /P 177 0 R /K [176] /ActualText (glucose ) /Type /StructElem /S /Span >> endobj 1025 0 obj << /Pg 52 0 R /P 177 0 R /K [177] /ActualText (in EBC ) /Type /StructElem /S /Span >> endobj 1026 0 obj << /Pg 52 0 R /P 177 0 R /K [178] /ActualText (possibly) /Type /StructElem /S /Span >> endobj 1027 0 obj << /Pg 52 0 R /P 177 0 R /K [179] /ActualText ( ) /Type /StructElem /S /Span >> endobj 1028 0 obj << /Pg 52 0 R /P 177 0 R /K [180] /ActualText (resulted from) /Type /StructElem /S /Span >> endobj 1029 0 obj << /Pg 52 0 R /P 177 0 R /K [181] /ActualText ( ) /Type /StructElem /S /Span >> endobj 1030 0 obj << /Pg 52 0 R /P 177 0 R /K [182] /ActualText (an enhanced ) /Type /StructElem /S /Span >> endobj 1031 0 obj << /Pg 52 0 R /P 177 0 R /K [183] /ActualText (leakage of ) /Type /StructElem /S /Span >> endobj 1032 0 obj << /Pg 52 0 R /P 177 0 R /K [184] /ActualText (glucose from the blood into the airway through impaired ) /Type /StructElem /S /Span >> endobj 1033 0 obj << /Pg 52 0 R /P 177 0 R /K [185] /ActualText (lung ) /Type /StructElem /S /Span >> endobj 1034 0 obj << /Pg 52 0 R /P 177 0 R /K [186] /ActualText (epithelial tight junctions, ) /Type /StructElem /S /Span >> endobj 178 0 obj << /Pg 59 0 R /P 81 0 R /K [1040 0 R 1041 0 R 1042 0 R 1043 0 R 1044 0 R 1045 0 R 1046 0 R 1047 0 R 1048 0 R 1049 0 R 1050 0 R 1051 0 R 1052 0 R 1053 0 R 1054 0 R 1055 0 R 1056 0 R 1057 0 R 1058 0 R 1059 0 R 1060 0 R 1061 0 R 1062 0 R 1063 0 R 1064 0 R 1065 0 R 110 0 R 1066 0 R 111 0 R 1067 0 R 1068 0 R 1069 0 R 1070 0 R 1071 0 R 1072 0 R 1073 0 R 1074 0 R 1075 0 R 1076 0 R 1077 0 R 1078 0 R 1079 0 R 1080 0 R 1081 0 R 1082 0 R 1083 0 R 1084 0 R 1085 0 R 1086 0 R 1087 0 R 1088 0 R 1089 0 R] /Type /StructElem /S /P >> endobj 1040 0 obj << /Pg 59 0 R /P 178 0 R /K [0] /ActualText (which ) /Type /StructElem /S /Span >> endobj 109 0 obj [1040 0 R 1041 0 R 1042 0 R 1043 0 R 1044 0 R 1045 0 R 1046 0 R 1047 0 R 1048 0 R 1049 0 R 1050 0 R 1051 0 R 1052 0 R 1053 0 R 1054 0 R 1055 0 R 1056 0 R 1057 0 R 1058 0 R 1059 0 R 1060 0 R 1061 0 R 1062 0 R 1063 0 R 1064 0 R 1065 0 R 1090 0 R 1066 0 R 1091 0 R 1067 0 R 1068 0 R 1069 0 R 1070 0 R 1071 0 R 1072 0 R 1073 0 R 1074 0 R 1075 0 R 1076 0 R 1077 0 R 1078 0 R 1079 0 R 1080 0 R 1081 0 R 1082 0 R 1083 0 R 1084 0 R 1085 0 R 1086 0 R 1087 0 R 1088 0 R 1089 0 R 1092 0 R 1093 0 R 1094 0 R 1095 0 R 1096 0 R 1097 0 R 1098 0 R 1099 0 R 1100 0 R 1101 0 R 1102 0 R 1103 0 R 1104 0 R 1105 0 R 1106 0 R 1107 0 R 1108 0 R 1109 0 R 1110 0 R 1111 0 R 1112 0 R 1113 0 R 1114 0 R 1115 0 R 1116 0 R 1117 0 R 1118 0 R 1119 0 R 1120 0 R 1121 0 R 1122 0 R 1123 0 R 1124 0 R 1125 0 R 1126 0 R 1127 0 R 1128 0 R 1129 0 R 1130 0 R 1131 0 R 1132 0 R 1133 0 R 1134 0 R 1135 0 R 1136 0 R 1137 0 R 1138 0 R 1139 0 R 1140 0 R 1141 0 R 1142 0 R 1143 0 R 1144 0 R 1145 0 R 1146 0 R 1147 0 R 1148 0 R 1149 0 R 1150 0 R 1151 0 R 1152 0 R 1153 0 R 1154 0 R 1155 0 R 1156 0 R 1157 0 R 1158 0 R 1159 0 R 1160 0 R 1161 0 R 1162 0 R 1163 0 R 1164 0 R 1165 0 R] endobj 1041 0 obj << /Pg 59 0 R /P 178 0 R /K [1] /ActualText (could be ) /Type /StructElem /S /Span >> endobj 1042 0 obj << /Pg 59 0 R /P 178 0 R /K [2] /ActualText (supported) /Type /StructElem /S /Span >> endobj 1043 0 obj << /Pg 59 0 R /P 178 0 R /K [3] /ActualText ( ) /Type /StructElem /S /Span >> endobj 1044 0 obj << /Pg 59 0 R /P 178 0 R /K [4] /ActualText (by ) /Type /StructElem /S /Span >> endobj 1045 0 obj << /Pg 59 0 R /P 178 0 R /K [5] /ActualText (an elevation of ) /Type /StructElem /S /Span >> endobj 1046 0 obj << /Pg 59 0 R /P 178 0 R /K [6] /ActualText (serum CC16) /Type /StructElem /S /Span >> endobj 1047 0 obj << /Pg 59 0 R /P 178 0 R /K [7] /ActualText (. ) /Type /StructElem /S /Span >> endobj 1048 0 obj << /Pg 59 0 R /P 178 0 R /K [8] /ActualText (H) /Type /StructElem /S /Span >> endobj 1049 0 obj << /Pg 59 0 R /P 178 0 R /K [9] /ActualText (igher ) /Type /StructElem /S /Span >> endobj 1050 0 obj << /Pg 59 0 R 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1128 0 R 1129 0 R 1130 0 R 1131 0 R 1132 0 R 1133 0 R 1134 0 R 1135 0 R 1136 0 R 1137 0 R] /Type /StructElem /S /P >> endobj 1092 0 obj << /Pg 59 0 R /P 179 0 R /K [52] /ActualText (T) /Type /StructElem /S /Span >> endobj 1093 0 obj << /Pg 59 0 R /P 179 0 R /K [53] /ActualText (his) /Type /StructElem /S /Span >> endobj 1094 0 obj << /Pg 59 0 R /P 179 0 R /K [54] /ActualText ( ) /Type /StructElem /S /Span >> endobj 1095 0 obj << /Pg 59 0 R /P 179 0 R /K [55] /ActualText (randomised, double) /Type /StructElem /S /Span >> endobj 1096 0 obj << /Pg 59 0 R /P 179 0 R /K [56] /ActualText (-) /Type /StructElem /S /Span >> endobj 1097 0 obj << /Pg 59 0 R /P 179 0 R /K [57] /ActualText (blind, crossover trial has the advantage of allowing for ) /Type /StructElem /S /Span >> endobj 1098 0 obj << /Pg 59 0 R /P 179 0 R /K [58] /ActualText (causal inference on the associations between ozone and adverse respiratory ) /Type /StructElem /S /Span >> endobj 1099 0 obj << /Pg 59 0 R /P 179 0 R /K [59] 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1143 0 R 1144 0 R 1145 0 R 1146 0 R 1147 0 R 1148 0 R 1149 0 R 1150 0 R 1151 0 R 1152 0 R 1153 0 R 1154 0 R 1155 0 R 1156 0 R 1157 0 R 1158 0 R 1159 0 R 1160 0 R 1161 0 R 1162 0 R 1163 0 R] /Type /StructElem /S /P >> endobj 1138 0 obj << /Pg 59 0 R /P 180 0 R /K [98] /ActualText (To conclude, t) /Type /StructElem /S /Span >> endobj 1139 0 obj << /Pg 59 0 R /P 180 0 R /K [99] /ActualText (his randomi) /Type /StructElem /S /Span >> endobj 1140 0 obj << /Pg 59 0 R /P 180 0 R /K [100] /ActualText (s) /Type /StructElem /S /Span >> endobj 1141 0 obj << /Pg 59 0 R /P 180 0 R /K [101] /ActualText (ed, double) /Type /StructElem /S /Span >> endobj 1142 0 obj << /Pg 59 0 R /P 180 0 R /K [102] /ActualText (-) /Type /StructElem /S /Span >> endobj 1143 0 obj << /Pg 59 0 R /P 180 0 R /K [103] /ActualText (blind, crossover) /Type /StructElem /S /Span >> endobj 1144 0 obj << /Pg 59 0 R /P 180 0 R /K [104] /ActualText (, controlled exposure) /Type /StructElem /S /Span >> endobj 1145 0 obj << /Pg 59 0 R 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The cycles refer to the 95% confidence ellipses. \(c\) The cladogram of ) /Type /StructElem /S /Span >> endobj 1417 0 obj << /Pg 74 0 R /P 203 0 R /K [27] /ActualText (nasal bacterial community from a linear discriminant effect size analysis. The red area ) /Type /StructElem /S /Span >> endobj 1418 0 obj << /Pg 74 0 R /P 203 0 R /K [28] /ActualText (represents significantly enriched ta) /Type /StructElem /S /Span >> endobj 1419 0 obj << /Pg 74 0 R /P 203 0 R /K [29] /ActualText (xa in the filtered air group; the green area ) /Type /StructElem /S /Span >> endobj 1420 0 obj << /Pg 74 0 R /P 203 0 R /K [30] /ActualText (represents significantly enriched taxa in the ozone group; and the yellow area ) /Type /StructElem /S /Span >> endobj 1421 0 obj << /Pg 74 0 R /P 203 0 R /K [31] /ActualText (represents no differences in taxa between the two groups. The central point ) /Type /StructElem /S /Span >> endobj 1422 0 obj << /Pg 74 0 R /P 203 0 R /K [32] /ActualText (represents the root of the tree \(bacteria\), and each rin) /Type /StructElem /S /Span >> endobj 1423 0 obj << /Pg 74 0 R /P 203 0 R /K [33] /ActualText (g represents the next lower ) /Type /StructElem /S /Span >> endobj 1424 0 obj << /Pg 74 0 R /P 203 0 R /K [34] /ActualText (taxonomic level \(from phylum to genus\). The diameter of each circle represents the ) /Type /StructElem /S /Span >> endobj 1425 0 obj << /Pg 74 0 R /P 203 0 R /K [35] /ActualText (relative abundance of the taxon.) /Type /StructElem /S /Span >> endobj 1426 0 obj << /Pg 74 0 R /P 203 0 R /K [36] /ActualText ( ) /Type /StructElem /S /Span >> endobj 1427 0 obj << /Pg 74 0 R /P 203 0 R /K [37] /ActualText (Abbreviations:) /Type /StructElem /S /Span >> endobj 1428 0 obj << /Pg 74 0 R /P 203 0 R /K [38] /ActualText ( ) /Type /StructElem /S /Span >> endobj 1429 0 obj << /Pg 74 0 R /P 203 0 R /K [39] /ActualText (ACE, abundance) /Type /StructElem /S /Span >> endobj 1430 0 obj << /Pg 74 0 R /P 203 0 R /K [40] /ActualText (-) /Type /StructElem /S /Span >> endobj 1431 0 obj << /Pg 74 0 R /P 203 0 R /K [41] /ActualText (based coverage ) /Type /StructElem /S /Span >> endobj 1432 0 obj << /Pg 74 0 R /P 203 0 R /K [42] /ActualText (estimator) /Type /StructElem /S /Span >> endobj 1433 0 obj << /Pg 74 0 R /P 203 0 R /K [43] /ActualText (; ) /Type /StructElem /S /Span >> endobj 1434 0 obj << /Pg 74 0 R /P 203 0 R /K [44] /ActualText (PCoA, principal coordinate analysis.) /Type /StructElem /S /Span >> endobj 1435 0 obj << /Pg 74 0 R /P 203 0 R /K [45] /ActualText ( ) /Type /StructElem /S /Span >> endobj 204 0 obj << /Pg 74 0 R /P 81 0 R /K [1436 0 R 1437 0 R] /Type /StructElem /S /P >> endobj 1436 0 obj << /Pg 74 0 R /P 204 0 R /K [46] /ActualText ( ) /Type /StructElem /S /Span >> endobj 1437 0 obj << /Pg 74 0 R /P 204 0 R /K [47] /ActualText ( ) /Type /StructElem /S /Span >> endobj 205 0 obj << /Pg 76 0 R /P 81 0 R /K [312 0 R] /Type /StructElem /S /P >> endobj 312 0 obj << /Pg 76 0 R /P 205 0 R /K [0] /ActualText ( ) /Type /StructElem /S /Span >> endobj 13 0 obj [278 0 0 0 0 0 0 0 0 0 389 0 278 333 0 0 0 0 0 0 0 0 0 0 0 0 333 0 0 0 0 0 0 722 0 722 0 0 0 0 0 0 0 0 0 0 0 778 0 0 722 0 611 0 0 0 0 0 0 0 0 0 0 0 0 556 611 556 611 556 333 611 611 278 0 556 278 889 611 611 611 611 389 556 333 611 556 778 556 556 500] endobj 17 0 obj << /Filter /FlateDecode /Length 340 >> stream x}Mn0vqH,CTeȂ̐͢yEPvdU#kZ )`G8&ӭ¯j^\M]i>20t |q\kN> stream x |ǟwfvw#lI$6W0 9A1jgRE+j4-TP^UAUZZe;BkSHy;;lf@"-**^ō;_7mjf= <W=콲{p';&V׌]^w`F?kb㜩9yW%byôI5_%azĬɵn]@nm6.(rW X 9o¥/]V0}Z .;oM@p ,]an\ ͋wQQrfocL.Zbc0 wM_gq)k/X60)+l]ڸjblOtaҦ˃k @|Y 9 p||M^]OP73Ѳn3K4|Z@4`Rԧ`)96-_^nNVcZPAx90 G_Ky~=KEFU> yMTqzQwreHr " IcIGȲ{u琸]ހsPfh`55> "#p1}ӥmfvm3o2Z#Z5Mc-c9 E?,S͒6aج K1): ̿c=b>cθVs#i!;wzg9ZccѪ2u9XOr G 1Yc]*ǡЌ@; G(cl }iq7Qgss@7`0\߄lw E=s`0 yf6o2 `0 `0 `0N?{=8c@Zп.4 i*bT>fSm`Ӏ7UӜVg }̏cjuD|7.=^{ p!0 #]q*'@wDDc5@= F05 fT+W`+l `Guj"=Ƹ<>E > +*Aj) Q@MAԳ uPÊf@OȄP͆0jdBP Q!u CQ #-ᨣ- QH"RZŨ娟BFԱ0F> :JQ'@DEuTNT: ƣN a0O`&LF0::8cQ@ 깊΅_f6٨PuFmsPσzcX"Ε?%ЀQ<̿.St9,? bXڬ X$VbK` ꥨUp>ereWr5p\h 4^+Pa.AkR\ Per Q+0FXz\z3\z A\z+\c|nSvX֡cNu#]p=pOnB7 އ.?B܊p<__*܁0܉܅ݨOQpjP[~-x~& <?GPI،R~~ Fѝ0.x(nx\~(MHяW^_#QE?7Qo~/?]=/p>W~ |*ßPٜ~O9q091999=釕97Cʜ~ۜ~H)snsߘ*sAeN?xo МlN?3}~=ٜoӟ/g\0"<'4 xĕo%zQC/NA4jӈxA8'PVq +߂{#?*f|K/}854ow rd" Zxti"V* 4](q0hDVh6iŷRjjL*U/_Ut_*UkZ?*f|1K/}<7AgH!0 #l8E=:tx Z[r·Q:УpӢeDJPb}+}+&OoP0K/}85ou`0=VS9YO]*:PZAS:U`zV5:Q3 z_ߊVH}+#&ZN ]qb~bz `[92N@}+5I[iVހAϋzQoMzVx}+lrܷ纕P|+m5!|w1{X[ E!0 #,,xѥYjFRT'|+JӁov0[RX]toEjQ纕+??/ k҇ɳn18)=`0zVS=d45RJO}+}JFd4jQo6)n4bNz h FjJ^VCu_*U zy sB {҇ɳn18졁`0=|+)(?:+[h4AQ ](qpMft,&d,&d0p7ƀA,=-YǷw_*_"cM˅)[8>Lss ')"1F]*EI#j4.4fj1ۭjh-vd5Fª*A`2LAc[x>7u_*_"cM|>&}<>1w`0 F0ߊqHwZ"jE܅(Z,l 6.mfau$пYmVQf٬1jIiMh7} \cMۋ|3o҇Slp{G  rd"rV;tzSNDjBpm.l.ˁ9d,3ֵX4M̢0Mq (jez'K "2g$K/}<BR@`0a!E*=zk.Zr9.a7:W.f'h7jX:Mh6t2V-Cnrsw[HKW09 `*<r.=-CJۙp'ING<\?hzٍ^'Dg s>ss*\3C`0 GاSDv}F`fh6=]^r@K \~OZ ՟?۟3*7Lx\\mgv=%rިfHvSn18Pg >,"oA^dj'& ))) TtSMoHjz Sm8M>w0%^q@ܟ=#_z)A >y z `H/ K#^F\0f 7l6d]͒$AAjj:St759+=Tz`0`V4%'{nr5f%a;לMx= )[Bjv SW_@0yQ :4#.!0 #OSDъLXa`R,vEbIIIQpz0+lNJrYY\ӋBAcTu%hL6I)iqBҷ;^~Vg H}<Mъ`0=’kХr&gI;.t2,מV;,kr2o(--릥)摴3ŞȑV;֩ި)2gK/}hŠC,v`0 FO p;)v8]80)/oĈP^x􈢼yY#v(?n8lch;wN'SAkH]~ _z_5ta0C`0 GzYX2R` \$I.˕݅˕ 5ŮpAveqiAiq.l=6]CFϊc|0ra*2gTK/}e|yp+MyINg|C :4!vK(U{#w_}=韛t뢑6q=`0z%NQ` cd!090.{QhP_H-I .ipK@cݶk7衕zp^x
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