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391.011 632.182 0.51 -246.104 re
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BT
/F1 1 Tf
14.944 0 0 14.944 100.12 712.403 Tm
0.0208 Tc
[(Comparison)-332.6(of)-332.9(induced)-336.4(s)0(putum)-334.7(with)-332.6(bronchial)-331.7(wash,)]TJ
-0.7815 -1.0357 TD
0.0212 Tc
[(bronchoalveolar)-333.6(l)2.5(avage)-329.7(and)-332.2(b)1.7(ronchial)-331.3(biopsies)-329.7(in)-332.2(COPD)]TJ
/F2 1 Tf
10.959 0 0 10.959 58.28 659.565 Tm
0 Tc
[(S.R.)-242.3(Rutgers)]TJ
/F3 1 Tf
5.6698 0 TD
0 Tw
(*)Tj
/F2 1 Tf
0.5018 0 TD
[(,)-241.5(W)0(.)-241.2(Timens)]TJ
/F3 1 Tf
5.2559 0 TD
(**)Tj
/F2 1 Tf
0.9984 0 TD
[(,)-241.5(H.F.)-242.5(Kaufmann)]TJ
/F3 1 Tf
7.1959 0 TD
(***)Tj
/F2 1 Tf
1.495 0 TD
[(,)-241.5(Th.W.)-242.7(van)-237.7(der)-239.1(Mark)]TJ
/F3 1 Tf
9.172 0 TD
(*)Tj
/F2 1 Tf
0.5018 0 TD
[(,)-241.5(G.H.)-241.1(Koe)]TJ
4.1437 0 TD
[(\310)-117.1(ter)]TJ
/F3 1 Tf
1.614 0 TD
(*)Tj
/F2 1 Tf
0.4966 0 TD
[(,)-241.5(D.S.)-242.3(Postma)]TJ
/F3 1 Tf
6.094 0 TD
(*)Tj
/F4 1 Tf
8.966 0 0 8.966 58.28 622.715 Tm
[(Comparison)-633.6(of)-633.7(induced)-637(sputum)-636.1(with)-633.4(br)31.4(onchial)-639.6(wash,)-632.7(br)31.4(onchoalveolar)-637.3(lavage)-631.2(and)]TJ
0 -1.0559 TD
[(br)31.4(onchial)-222.3(biopsies)-224.1(in)-222.7(COPD.)-224.3(S.R.)-223.3(Rutgers,)-222.3(W)82.2(.)-217.9(T)52.5(imens,)-228.3(H.F)124.1(.)-217.9(Kauffman,)-226.6(Th.W)81.8(.)-217.9(van)-225.9(der)-220.7(Mark,)]TJ
T*
[(G.H.)-333.8(Koe)]TJ
3.4966 -0.019 TD
(\310)Tj
0.3794 0.019 TD
[(ter)105.7(,)-331.7(D.S.)-336.9(Postma.)]TJ
/F5 1 Tf
7.1828 0 TD
(#)Tj
/F4 1 Tf
0.999 0 TD
[(ERS)-334.2(Journals)-335.6(Ltd)-334.6(2000.)]TJ
/F6 1 Tf
-12.0578 -1.0559 TD
[(ABSTRACT)66.7(:)-240.7(I)0(t)-247.7(i)0(s)-242.8(unclear)-248.2(how)-240.6(cellular)-247.6(and)-248.6(soluble)-245.9(inflammatory)-246.4(markers)-248.9(in)-240.2(induced)]TJ
T*
[(sputum)-431.6(r)13.4(elate)-436.6(to)-429.9(markers)-432.3(in)-429.9(lavage)-429.1(fluid)-430.3(and)-431.9(biopsies)-430(in)-429.9(chron)12.1(ic)-431.1(obstructive)-432.7(pul-)]TJ
T*
[(monary)-495.3(disease)-505.2(\(COPD\).)-500.6(This)-498(was)-496.2(investigated)-504.3(and)-495.2(also)-501.1(the)-497.3(possible)-499.5(differen)9.6(ces)]TJ
T*
[(between)-338.6(subjects)-332.1(with)-338.3(COPD)-332.4(and)-330.8(healthy)-338.2(controls)-321.1(assessed.)]TJ
0.999 -1.0559 TD
[(Eighteen)-462.3(nonatopic)-455.8(subjects)-464.8(with)-458.4(COPD)-458.8(and)-457.2(1)51.1(1)-461.1(healthy)-458.3(controls)-447.5(were)-449.5(studied.)]TJ
-0.999 -1.0559 TD
[(Sputum)-346.8(was)-344.4(induced)-346.8(by)-345.3(inhalation)-346.5(of)-347.7(hypertonic)-347.4(saline.)-345.6(The)-349.3(airways)-344.5(were)-342(lavaged,)]TJ
T*
[(using)-466.1(the)-465.7(first)-470.6(50)-466.9(mL)-465.7(for)-467.1(bronc)12.2(hial)-469.2(wash)-462.6(\(BW\))-472(and)-463.5(the)-465.7(subsequent)-464.9(150)-466.4(mL)-465.7(for)]TJ
T*
[(bronc)12.2(hoalveolar)-326.6(lavage)-321.6(\(BAL\),)-324.8(and)-318.1(biopsies)-328.8(wer)11.3(e)-321.8(taken)-324.2(fr)12.9(om)-321.9(subsegmental)-324.1(carinae.)]TJ
0.999 -1.0496 TD
[(Neutrophils)-341.3(wer)11.3(e)-347(the)-345.6(pr)15.3(edominant)-348.8(cell)-350(type)-345(in)-341.4(sputum)-349.4(in)-341.4(COPD)-345(\(median)-351.3(77.3%\))]TJ
-0.999 -1.0559 TD
[(but)-217.9(not)-219.3(in)-221.3(BW)-218.2(\(5.5%\))-216.8(and)-217(BAL)-219.9(fluid)-221.7(\(1.7%\).)-219.7(Differ)8.5(ential)-222.3(cell)-217.3(counts)-217.3(in)-221.3(sputum)-216.6(did)-219.3(not)]TJ
T*
[(correlate)-256.9(with)-268.8(the)-263.4(counts)-267.9(in)-265.5(BW)-211.9(or)-264.3(BAL)-264.1(fluid)-265.9(or)-264.3(biopsies,)-268.5(wher)13.3(eas)-265(sputum)-267.2(eosinophil)]TJ
T*
[(cationic)-322.3(protein)-306.3(\(ECP\))-320.7(levels)-324.9(correlate)8.7(d)-314.2(with)-325.7(BW)-313(fluid)-322.8(ECP)-319.8(levels)-318.6(\()]TJ
/F7 1 Tf
28.902 0 TD
(r)Tj
/F8 1 Tf
0.5501 0 TD
(=)Tj
/F6 1 Tf
0.5564 0 TD
[(0.66,)-314.1(p)]TJ
/F8 1 Tf
2.8706 0 TD
(=)Tj
/F6 1 Tf
0.5501 0 TD
(0.007\))Tj
-33.4292 -1.0559 TD
[(and)-235.9(sputum)-241.9(interleukin-8)-242.7(\(IL-8\))-239.7(concentration)-245.4(with)-237.1(BAL)-238.8(fluid)-240.6(IL-8)-245.1(concentration)-239.1(\()]TJ
/F7 1 Tf
34.8961 0 TD
(r)Tj
/F8 1 Tf
0.5501 0 TD
(=)Tj
/F6 1 Tf
-35.4462 -1.0559 TD
[(0.52,)-320.4(p)]TJ
/F8 1 Tf
2.8769 0 TD
(=)Tj
/F6 1 Tf
0.5501 0 TD
[(0.026\).)-320.4(Subjects)-329.4(with)-319.3(COPD)-326.1(had)-324.4(a)-322(higher)-324.8(perce)11.2(ntage)-325.6(of)-322.4(sputum)-324.1(neutr)11.2(ophils)]TJ
-3.427 -1.0559 TD
[(and)-210.6(eosinophils)-214.4(and)-204.3(higher)-204.7(concentrations)-214.5(of)-208.6(ECP)-212.3(and)-210.6(IL-8)-207.2(than)-211.1(healthy)-211.7(controls.)-203.8(The)]TJ
T*
[(higher)-350.1(perce)11.2(ntages)-351.5(of)-347.7(eosinophils)-347.2(and)-343.4(concentrations)-353.6(of)-347.7(ECP)-345.1(were)-342(also)-349.3(seen)-345.1(in)-347.7(BW)]TJ
T*
[(and)-299.1(BAL)-295.7(fluid.)-294.1(Finally)44.9(,)-293.8(higher)-299.5(numbers)-296.9(of)-297.1(macrop)10.8(hages)-294.2(and)-299.1(eosinophils)-296.6(were)-291.4(found)]TJ
T*
[(in)-335.1(biopsies.)]TJ
0.999 -1.0559 TD
[(In)-302.3(conclusion,)-302.5(induced)-302.5(sputum)-305.1(is)-299.7(derived)-305.1(fr)12.9(om)-303(a)-303(differ)13.3(ent)-307.6(compartment)-303.5(fr)12.9(om)-303(BW)]TJ
-0.999 -1.0559 TD
[(and)-394(BAL)-403.2(fluid)-398.7(and)-394(biopsies.)-401.3(Induced)-396.2(sputum)-400(may)-397.3(be)-402(useful)-396.8(for)-397.6(studying)-400.9(the)-396.1(con-)]TJ
T*
[(tribution)-408.6(of)-404.6(luminal)-412.2(neutr)11.2(ophils)-411.1(and)-400.3(eosinophils)-410.4(in)-411(chron)12.2(ic)-405.8(obstructive)-407.4(pulmonary)]TJ
T*
(disease.)Tj
/F4 1 Tf
T*
[(Eur)-331.9(Respir)-333.8(J)-334.4(2000;)-333.5(15:)-334.6(109\2611)72.1(15.)]TJ
/F3 1 Tf
7.97 0 0 7.97 401.499 623.735 Tm
[(Depts)-293.3(of)-301.8(*Pulmonolog)13.2(y)66.1(,)-297.7(**Pathology)-291.4(and)]TJ
0 -1.067 TD
[(***Aller)17.5(gology)67.1(,)-247.9(University)-238(Hospital,)-240.9(Gro-)]TJ
0 -1.0599 TD
[(ningen,)-322(the)-336.5(Netherlands)10.4(.)]TJ
0 -2.1268 TD
[(Corresponde)11.8(nce:)-333.4(S.R.)-323.4(Rutgers)]TJ
0 -1.0599 TD
[(Dept)-329.8(of)-330.3(Pulmonology)]TJ
0 -1.067 TD
[(University)-323.3(Hospital)-327.3(Groningen)]TJ
0 -1.0599 TD
[(P)103.9(.O.)-325.5(Box)-332.7(30.001)]TJ
T*
[(9700)-325.9(RB)-332.4(Groninge)12.8(n)]TJ
0 -1.067 TD
[(The)-329.7(Netherlands)]TJ
0 -1.0599 TD
[(Fax:)-325.1(31)-330.1(503619320)]TJ
0 -2.1268 TD
[(Keywords)11.5(:)-334.6(Biopsy)]TJ
0 -1.0599 TD
[(bronchoalv)13.4(eolar)-331.5(lavage)]TJ
0 -1.067 TD
[(chronic)-327.3(obstructive)-324.8(pulmonary)-324.3(disease)]TJ
0 -1.0599 TD
[(inflammatio)7.7(n)]TJ
T*
(sputum)Tj
0 -2.1268 TD
[(Received:)-327.9(Februar)11.5(y)-332.2(4)-332.2(1999)]TJ
0 -1.067 TD
[(Accepted)-325.4(after)-331.6(revision)-329.8(August)-320.7(8)-332.2(1999)]TJ
0 -2.1197 TD
[(This)-282.4(study)-277.6(was)-280.9(supported)-268.3(by)-280.3(the)-286.7(Stichtin)10.5(g)]TJ
0 -1.067 TD
[(Astma)-734.6(Bestrijding)-731.3(and)-732.5(Astra)-741.6(Pharma-)]TJ
0 -1.0599 TD
[(ceutica,)-326.4(the)-329.4(Netherlands.)]TJ
9.963 0 0 9.963 68.258 359.887 Tm
[(In)19.6(fl)17.3(am)12(ma)17.7(ti)16.5(on)-286.1(of)-293.3(th)18.9(e)-297.1(a)0(i)12.8(r)0(w)21.4(a)0(y)15.1(s)-297.9(is)-289.6(of)13.9(t)13.9(e)0(n)-292.2(p)0(r)19.6(e)0(s)13.9(e)0(n)20.8(t)-299.1(in)-288.4(ch)15.1(ro)19.6(ni)13.2(c)]TJ
-1.0015 -1.0755 TD
[(ob)15.5(st)17.7(ru)19.6(ct)18.5(iv)18.8(e)-484.9(p)0(u)15.5(l)0(m)15.7(o)0(n)21.2(a)0(r)13.5(y)-484.5(di)18.9(se)19.6(as)14(e)-484.9(\()0(C)20.6(O)0(P)12.4(D)12.4(\))-486.1(an)15.1(d)-484.5(c)0(o)20.8(n)0(s)14.4(i)0(s)17.7(t)0(s)-477.4(o)0(f)]TJ
T*
[(in)18.9(cr)13.5(ea)20.4(se)13.9(d)-205.6(n)0(u)15.5(m)0(b)18.1(e)0(r)13.5(s)-206.8(of)-202.3(ma)12(cr)19.2(op)15.5(ha)20.8(ge)15.1(s)-212.5(a)0(n)20.8(d)-211.3(ly)18.9(mp)18.1(ho)15.5(cy)15.1(te)18.4(s)-212.5(i)0(n)-197.4(t)0(h)13.2(e)]TJ
T*
[(ai)18.4(rw)15.7(ay)-354.7(wa)16.9(ll)-359.1(an)15.1(d)-365(i)13.9(nc)15.1(re)19.2(as)14(ed)-354.7(nu)15.5(mb)18.1(er)19.2(s)-366.2(o)0(f)-355.9(n)0(e)15.1(u)0(t)18.9(r)0(o)19.6(p)0(h)15.5(i)0(l)16.5(s)-366.1(i)13.9(n)-365(th)13.2(e)]TJ
0 -1.0698 TD
[(ai)18.4(rw)15.7(ay)-297.8(lu)18.9(me)17.7(n.)-297.1(A)12.4(i)0(r)17.3(w)0(a)16.9(y)-308.1(in)18.9(fl)17.3(am)17.7(ma)17.7(ti)16.5(on)-297.4(ha)20.8(s)-303.6(b)0(e)15.1(e)0(n)-292.2(s)0(t)17.7(u)0(d)15.5(i)0(e)18.4(d)-302.4(ex)15.1(-)]TJ
0 -1.0755 TD
[(te)18.4(ns)14.4(iv)18.9(el)18.4(y)-234.1(i)0(n)-225.8(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(i)0(a)18.4(l)-236.5(bi)18.9(op)15.5(sy)-224.7(sa)19.6(mp)18.1(le)12.8(s)-229.6(a)0(n)15.1(d)-234.1(br)19.6(on)15.5(ch)20.8(oa)15.1(lv)18.9(eo)15.1(la)18.4(r)]TJ
T*
[(la)18.4(va)15.1(ge)-269.4(\(B)20.6(AL)13.2(\))-275.5(f)0(l)17.3(u)0(i)13.2(d)0(,)-268.6(b)0(u)21.2(t)-282(th)18.9(e)-280(i)13.9(nv)15.5(as)19.6(iv)13.2(en)20.8(es)13.9(s)-275.1(o)0(f)-270.6(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(o)0(s)14.4(c)0(o)20.8(p)0(y)]TJ
T*
[(ma)17.7(ke)15.1(s)-223.9(i)0(t)-211.1(l)0(e)18.4(s)0(s)-214.5(f)0(e)13.5(a)0(s)19.6(i)0(b)18.9(l)0(e)-214.9(f)0(o)19.6(r)-224.3(la)18.4(r)14.7(g)0(e)20.8(-)0(s)18.4(c)0(a)14.7(l)0(e)-214.9(d)0(i)18.9(a)0(g)15.1(n)0(o)21.2(s)0(t)17.7(i)0(c)-214.9(a)0(n)15.1(d)-222.7(fo)19.6(ll)16.5(ow)17.3(-)]TJ
T*
[(up)-371.4(st)17.7(ud)21.2(ie)18.4(s.)-372.2(S)11.4(p)0(u)15.5(t)0(u)18.9(m)-379.5(in)18.9(du)15.5(ct)18.4(io)18.9(n)-376.3(h)0(a)15.1(s)-377.5(ga)15.1(i)13.9(n)0(e)15.1(d)-376.3(in)-368.1(in)13.2(te)18.4(re)19.2(st)-369.3(as)-373(a)]TJ
T*
[(to)18.9(ol)-294.1(fo)13.9(r)-298.3(s)0(t)17.7(u)0(d)15.5(y)0(i)18.9(n)0(g)-291.7(a)0(i)12.8(r)0(w)21.4(a)0(y)-297.8(i)0(n)18.9(f)0(l)17.3(a)0(m)17.7(m)0(a)17.7(t)0(i)16.5(o)0(n)-297.4(i)0(n)-294.1(C)11.6(OP)18.1(D)-306.3(i)0(n)-294.1(r)0(e)19.2(c)0(e)14.7(n)0(t)]TJ
T*
[(ye)15.1(ar)19.2(s,)-366.5(si)17.7(nc)20.8(e)-376.7(i)0(t)-370.5(i)0(s)-363.6(n)0(o)15.5(n)0(i)18.9(n)0(v)21.2(a)0(s)13.9(i)0(v)18.9(e)0(,)-365.7(e)0(a)14.7(s)0(i)17.7(l)0(y)-362.4(p)0(e)15.1(r)0(f)18(o)0(r)14(m)0(e)17.7(d)-376.3(an)20.8(d)-376.3(w)0(e)16.9(l)0(l)]TJ
T*
[(to)18.9(le)18.4(ra)13.5(te)18.4(d.)-336.9(Th)17.1(er)13.5(ef)19.2(or)19.6(e,)-343(sp)20(ut)18.9(um)-340.4(in)18.9(du)15.5(ct)18.4(io)18.9(n)-347.9(m)0(i)15.7(g)0(h)15.5(t)-350.3(be)-337.7(an)-337.7(al)18.4(te)12.8(r)20.4(-)]TJ
T*
[(na)15.1(ti)22.2(ve)-337.7(to)-334(br)19.6(on)15.5(ch)15.1(os)20(co)20.8(py)-337.3(fo)19.6(r)-343.8(m)0(o)12.4(n)0(i)18.9(t)0(o)18.9(r)0(i)17.3(n)0(g)-337.3(a)0(i)18.4(r)0(w)15.7(a)0(y)-332(i)0(n)18.9(f)0(l)17.3(a)0(m)12(m)0(a)17.7(-)]TJ
T*
[(ti)16.5(on)-314.5(in)-316.9(C)11.6(O)0(P)12.4(D)12.4(.)]TJ
1.0015 -1.0471 TD
[(Ne)16.9(ut)18.9(ro)13.9(ph)21.2(il)16.5(s)-258(h)0(a)20.8(v)0(e)-246.6(b)0(e)15.1(e)0(n)-246.6(s)0(h)20(o)0(w)17.3(n)-256.8(to)-248.6(be)-246.6(pr)19.6(es)13.9(en)20.8(t)-253.5(i)0(n)-248.6(i)0(n)18.9(c)0(r)13.5(e)0(a)20.4(s)0(e)13.9(d)]TJ
-1.0015 -1.0755 TD
[(pe)15.1(rc)19.2(en)15.1(t)13.9(a)0(g)15.1(e)0(s)-384.4(i)0(n)-385.2(i)0(n)18.8(d)0(u)21.2(c)0(e)14.7(d)-393.4(sp)20(ut)18.9(um)-385.9(in)-385.2(CO)18.3(PD)-385.9(an)15.1(d)-393.4(t)13.9(he)15.1(se)-384.4(pe)15.1(r)20.4(-)]TJ
T*
[(ce)14.7(nt)18.9(ag)20.8(es)-441.3(co)20.8(rr)18(el)12.8(at)18.4(e)-445(n)0(e)15.1(g)0(a)20.8(t)0(i)16.5(v)0(e)15.1(l)13.9(y)-450.3(w)12.4(it)16.5(h)-450.3(t)13.9(he)-440.1(fo)19.6(rc)13.5(ed)-434.4(ex)15.1(pi)18.9(ra)19.2(to)13.2(ry)]TJ
T*
[(vo)15.5(lu)18.8(me)-357.9(in)-356.7(on)21.2(e)-371.1(s)0(e)19.6(c)0(o)20.8(n)0(d)-360(\()0(F)20.4(E)0(V)]TJ
7.97 0 0 7.97 172.403 178.072 Tm
(1)Tj
9.963 0 0 9.963 176.258 178.072 Tm
[(\))-366.6([)0(1)13.9(])0(.)-372.6(The)-382.4(concent)-8.9(ration)-381.2(of)]TJ
-11.842 -1.0755 TD
[(the)-363.6(neutrophil)-369.6(chemo)-7.8(tactic)-365.7(cytokine)-364.5(inte)-8.2(rleukin-8)-368(\(IL-8\))]TJ
T*
[(is)-312.4(also)-308.6(incre)-8.6(ased)-312.3(in)-311.2(induce)-7.8(d)-308.1(sputu)-7.4(m)-305.5(a)-6.9(nd)-308.8(highest)-313.3(in)-311.2(those)]TJ
T*
[(with)-290.6(the)-289.6(highes)-8.6(t)-282(percent)-10.5(ages)-289.6(of)-287.7(neutr)-8.2(ophils)-289.4([1].)-290.4(The)-291.3(neu-)]TJ
T*
[(troph)-7.8(il)-319.3(medi)-9(ators)-322.4(myel)-9(operoxidase)-327.7(an)-7.6(d)-319.4(lipocali)-10.7(n)-319.4(and)-321.4(the)]TJ
0 -1.0698 TD
[(eosin)-7.8(ophil)-441.1(medi)-9(ators)-447.6(eosinophil)-448.8(cationic)-446.9(prote)-8.2(in)-442.1(\(ECP\))]TJ
0 -1.0755 TD
[(and)-406.7(eosin)-7.8(ophil)-412.6(peroxidase)-412.3(h)-6.5(ave)-407.1(also)-411.1(been)-407.9(shown)-413(to)-407.9(be)]TJ
25.1977 24.697 TD
[(incre)-8.6(ased)-329.4(in)-322.6(induce)-7.8(d)-319.4(sputu)-7.4(m)-322.6([2].)-324.5(The)-325.5(latte)-11.8(r)-321(two)-327.3(markers)]TJ
0 -1.0755 TD
[(did)-294.9(not)-294.9(decreas)-9.7(e)-291.4(after)-300.4(2)-291(weeks)]TJ
/F9 1 Tf
12.1835 0 TD
(')Tj
/F3 1 Tf
0.5122 0 TD
[(treatmen)-11.1(t)-293.4(with)-296.3(inhaled)-295.4(or)]TJ
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0 -1.0527 TD
[(At)-229.8(th)18.9(e)-240.2(s)0(e)19.6(c)0(o)15.1(n)0(d)-229.2(v)0(i)18.9(s)0(i)17.7(t)0(,)-231.1(s)0(p)20(u)0(t)18.9(u)0(m)-232.3(w)0(a)16.9(s)-235.3(in)13.2(du)21.2(ce)14.7(d.)-228.8(A)12.4(t)-242.1(th)18.9(e)-240.2(t)0(h)18.9(i)0(r)17.3(d)-234.1(vi)13.2(si)17.7(t,)]TJ
T*
[(7\261)15.5(14)-280.4(da)20.8(ys)-287.2(af)19.2(te)18.4(r)-292.6(v)0(i)18.9(s)0(i)17.7(t)-293.4(2,)-280(br)13.9(on)21.2(ch)15.1(os)20(co)15.1(py)-280.4(wi)14.9(th)-282.7(br)19.6(on)15.5(ch)15.1(oa)20.8(lv)18.9(eo)15.1(-)]TJ
0 -1.0471 TD
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/F4 1 Tf
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[(Spir)27.5(ometry)]TJ
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1.0015 -1.8551 TD
[(Sp)16.3(ir)17.3(om)18.1(et)18.5(ry)-503.9(w)12.4(a)0(s)-503.9(p)0(e)20.8(r)0(f)12.4(o)0(r)19.6(m)0(e)17.7(d)-512.9(us)20(in)18.9(g)-507.2(a)-513.3(ca)20.4(li)16.5(br)19.6(at)12.8(ed)-497(wa)16.9(te)12.8(r)20.4(-)]TJ
-1.0015 -1.0471 TD
[(se)19.6(al)12.8(ed)-303.5(sp)20(ir)17.3(om)12.4(et)18.4(er)-305.1(\(L)15.5(od)21.2(e,)-303.2(Gr)15.7(on)15.5(in)18.9(ge)15.1(n,)-302.7(th)18.9(e)-314.2(N)0(e)16.9(t)0(h)18.9(e)0(r)13.5(l)0(a)18.4(n)0(d)21.2(s)0(\))-305.9(a)0(c)14.7(-)]TJ
0 -1.0528 TD
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0 -1.0471 TD
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/F4 1 Tf
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[(Sputum)-340.9(induction)]TJ
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[(Sp)16.3(ut)18.9(um)-516.8(wa)16.9(s)-519.8(i)0(n)13.2(d)0(u)21.2(c)0(e)14.7(d)]TJ
/F4 1 Tf
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[(vi)18.5(a)]TJ
/F3 1 Tf
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[(in)13.2(ha)20.8(la)18.4(ti)16.5(on)-513.7(of)-515.3(a)-524.7(h)0(y)15.5(p)0(e)20.8(r)0(t)17.3(o)0(n)15.5(i)0(c)]TJ
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0 -1.0471 TD
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[(w)266.1(a)283(sc)266.1(a)280.8(l)266.1(i)282.6(b)266.1(r)285.7(a)266.1(t)284.5(e)266.1(dt)266.1(oa)266.1(n)8.1(o)266.1(u)281.6(t)266.1(p)285(u)266.1(to)266.1(f)6.9(1)266.1(.)282(5)-2.1(m)266.1(L)]TJ
/F11 1 Tf
14.8125 0.1992 TD
0 Tc
(.)Tj
/F3 1 Tf
0.2675 -0.1992 TD
[(mi)15.7(n)]TJ
7.472 0 0 6.641 223.653 116.957 Tm
-0.0185 Tc
(-1)Tj
9.963 0 0 9.963 232.384 112.535 Tm
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[(an)20.8(d)-273.9(p)0(r)19.6(o)0(d)15.5(u)0(c)20.8(e)0(d)]TJ
7.7221 66.1583 TD
[(pa)15.1(rt)17.3(ic)18.4(le)18.4(s)-337.7(w)12.4(it)16.5(h)-336.5(a)-331.2(di)18.9(am)17.7(et)18.4(er)-327.9(of)-321.8(4.)15.9(5)]TJ
/F8 1 Tf
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(m)Tj
/F3 1 Tf
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[(ch)15.1(lo)18.8(ri)17.3(de)-212.5(of)-213.7(3,)-217.4(4)-222.7(a)0(n)20.8(d)-222.7(5%)-214.4(\(w)15.7(ei)18.4(gh)15.5(t/)16.5(vo)21.2(lu)13.2(m)13.2(e)0(\))-219.8(w)12.4(er)13.5(e)-223.1(n)0(e)20.8(b)0(u)15.5(l)0(i)16.5(z)0(e)20.4(d)-222.7(at)]TJ
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/F9 1 Tf
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(8)Tj
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[(C\))-326.5(fo)19.6(r)-332.4(7)-325.1(mi)15.7(n)-330.8(e)0(a)14.7(c)0(h)20.8(,)-330.4(an)15.1(d)-325.1(a)0(d)15.1(m)0(i)15.7(n)0(-)]TJ
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0 -1.0471 TD
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0 -1.0528 TD
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7.97 0 0 7.97 483.194 708.888 Tm
(1)Tj
9.963 0 0 9.963 489.543 708.888 Tm
[(ma)17.7(no)15.5(eu)15.1(vr)19.6(es)]TJ
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/F4 1 Tf
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[(vi)12.8(a)]TJ
/F3 1 Tf
1.4454 0 TD
[(a)-251.6(T)40.6(ur)13.9(bu)21.2(ha)15.1(le)18.4(r)]TJ
/F5 1 Tf
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[(FE)17.9(V)]TJ
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(1)Tj
9.963 0 0 9.963 331.653 677.48 Tm
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0 -1.0528 TD
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0 -1.0471 TD
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0 -1.0527 TD
[(wi)14.9(th)-499(wa)16.9(te)12.8(r)60.2(.)-506.8(T)12.2(h)0(e)15.1(y)-507.2(we)16.9(re)-504.3(th)18.9(en)-497(en)15.1(co)20.8(ur)13.9(ag)20.8(ed)-502.7(to)-499(co)15.1(ug)21.2(h)-507.2(a)0(n)15.1(d)]TJ
0 -1.0471 TD
[(ex)15.1(pe)15.1(ct)18.4(or)19.6(at)18.5(e)-354(s)0(p)20(u)0(t)18.9(u)0(m)-340.4(i)0(n)13.2(t)0(o)-339.7(a)-348.3(st)17.7(er)19.2(il)16.5(e)-354(p)0(l)18.9(a)0(s)19.6(t)0(i)16.5(c)-348.3(co)15.1(nt)18.9(ai)18.5(ne)15.1(r)43.2(,)-353.2(wh)17.3(ic)18.4(h)]TJ
0 -1.0527 TD
[(wa)16.9(s)-280.8(k)0(e)20.8(p)0(t)-265.7(o)0(n)-269(i)0(c)18.4(e)0(.)-269(T)12.2(he)-269.4(pr)19.6(oc)15.1(ed)15.1(ur)19.6(e)-274.3(w)0(a)16.9(s)-275.1(te)12.8(rm)16.5(in)18.9(at)18.4(ed)-269.4(af)19.2(te)18.4(r)-275.5(t)0(h)13.2(r)0(e)19.2(e)]TJ
0 -1.0471 TD
[(pe)15.1(ri)17.3(od)15.5(s)-252.3(o)0(f)-242.1(7)-251.2(mi)15.7(n)-256.8(o)0(r)-242.1(a)0(f)19.2(t)0(e)12.8(r)-252.7(a)-251.6(f)0(a)19.2(l)0(l)-245.3(i)0(n)-248.6(F)11.4(EV)]TJ
7.97 0 0 7.97 457.398 604.29 Tm
(1)Tj
9.963 0 0 9.963 463.918 604.29 Tm
(of)Tj
/F10 1 Tf
1.0698 0 TD
($)Tj
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0.8251 0 TD
[(20)21.2(%)-253.5(f)0(r)12.3(o)0(m)-243.7(t)0(h)18.9(e)]TJ
-17.4131 -1.0528 TD
[(ba)15.1(se)19.6(li)16.5(ne)-314.9(va)15.1(lu)18.9(e.)]TJ
/F4 1 Tf
0 -2.3559 TD
[(Spu)-8(tum)-333(pr)25.7(ocessing)]TJ
/F3 1 Tf
1.0015 -1.8494 TD
[(Sp)16.3(ut)18.9(um)-306.3(wa)16.9(s)-309.2(p)0(r)13.9(o)0(c)20.8(e)0(s)13.9(s)0(e)19.6(d)-313.7(w)12.4(i)0(t)16.5(h)0(i)18.8(n)-313.7(15)-303.1(mi)15.7(n)-308.1(a)0(f)13.5(t)13.9(er)-305.1(te)18.5(rm)16.5(in)13.2(at)18.5(io)18.8(n)]TJ
-1.0015 -1.0471 TD
[(of)-259.2(th)18.8(e)-268.6(i)0(n)18.9(d)0(u)21.2(c)0(t)12.8(i)0(o)18.9(n)0(.)-257.2(T)12.2(he)-258(vo)15.5(lu)18.8(me)-255.5(of)-259.2(th)18.9(e)-268.6(w)12.4(ho)15.5(le)-254.7(sp)14.4(ut)18.9(um)-255.1(sa)14(mp)18.1(le)]TJ
0 -1.0528 TD
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0 -1.0471 TD
[(th)13.2(re)19.2(it)16.5(ol)-248.6(\(S)20.4(pu)15.5(to)18.8(ly)18.9(si)17.7(n;)-248.6(Ca)16.1(lb)18.9(io)13.2(ch)20.8(em)12(,)-256.5(L)12.2(a)-257.3(J)0(o)14.4(l)0(l)22.2(a)0(,)-251.9(C)11.6(A,)-249.8(US)18.1(A\))-251.7(wa)16.9(s)]TJ
0 -1.0528 TD
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0 -1.0471 TD
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[(at)-243.3(4)]TJ
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(6)Tj
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[(ce)14.7(ll)16.5(s)]TJ
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T*
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0 -1.0471 TD
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0 -1.0528 TD
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0 -1.0471 TD
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/F4 1 Tf
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[(Br)27.3(onchosc)-7.3(opy)]TJ
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0 -1.0471 TD
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[(pr)13.9(ew)16.9(ar)19.2(me)17.7(d)-478.8(t)13.9(o)-478.8(3)0(7)]TJ
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-7.4432 -1.0471 TD
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BT
/F3 1 Tf
9.963 0 0 9.963 58.28 771.647 Tm
0 g
/GS2 gs
0 Tc
[(la)18.4(be)15.1(ll)16.5(ed)-388.9(B)11.6(A)0(L)13.2(.)-393(Af)15.7(te)18.4(r)-400.7(c)0(o)20.8(m)0(p)12.4(l)0(e)18.4(t)0(i)16.5(o)0(n)-388.5(o)0(f)-390.1(l)13.9(av)15.1(ag)15.1(e,)-388.5(br)19.6(on)21.2(ch)15.1(ia)18.4(l)-401.5(b)0(i)18.9(-)]TJ
0 -1.0471 TD
[(op)15.5(sy)-219(sa)19.6(mp)18.1(le)12.8(s)-229.6(w)12.4(er)13.5(e)-228.8(t)0(a)18.4(k)0(e)15.1(n)-228.4(fr)18(om)-220.9(su)20(bs)14.4(eg)20.8(me)12(nt)18.9(al)-220.6(ca)20.4(ri)11.6(na)20.8(e)-228.8(o)0(f)-219.4(t)0(h)13.2(e)]TJ
0 -1.0528 TD
[(ri)17.3(gh)15.5(t)-350.3(o)0(r)-344.6(l)0(e)18.4(f)0(t)-346.9(l)0(o)18.9(w)0(e)16.9(r)-355.2(l)13.9(o)0(b)15.5(e)-354(us)20(in)18.9(g)-353.6(c)0(u)15.1(p)-353.6(fo)19.6(rc)19.2(ep)15.1(s)-349.1(\()0(O)15.7(l)0(y)13.2(m)0(p)18.1(u)0(s)-344.2(B)11.6(F-)]TJ
0 -1.0471 TD
-0.0165 Tc
[(2)-16.5(1)-1(C)-4.9(;)-344(Ol)-16.5(ym)-16.5(pu)-16.5(s)-332.2(O)-16.5(pt)-16.5(ic)-16.5(al)-16.5(\).)]TJ
/F4 1 Tf
0 -3.1583 TD
0 Tc
[(Lavage)-340.3(pr)31.4(ocessi)-10.1(ng)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(Th)17.1(e)-393.8(B)0(W)-314.7(a)0(n)15.1(d)-393.4(BA)12.6(L)-391.8(f)0(l)17.3(u)0(i)18.9(d)-399.1(w)12.4(e)0(r)13.5(e)-393.8(pl)18.9(ac)14.7(ed)-383.2(on)-388.5(ic)18.4(e)-393.8(a)0(n)15.1(d)-393.4(pr)13.9(o-)]TJ
-1.0015 -1.0471 TD
[(ce)14.7(ss)18.9(ed)-377.5(wi)14.9(th)18.9(in)-379.5(10)-382.8(mi)15.7(n)-387.7(a)0(f)19.2(t)0(e)18.4(r)-389.3(re)13.5(co)20.8(ve)15.1(ry)82.2(.)-387.3(T)0(h)17.1(e)-388.1(BW)-309(an)15.1(d)-387.7(B)11.6(AL)]TJ
0 -1.0527 TD
[(fl)17.3(ui)18.9(d)-205.6(w)0(e)16.9(r)0(e)-197(f)0(i)17.3(l)0(t)16.5(e)0(r)19.2(e)0(d)-201.1(t)0(h)18.9(r)0(o)19.6(u)0(g)15.5(h)-205.6(48)21.2(-)]TJ
/F8 1 Tf
11.6372 0 TD
0 Tw
(m)Tj
/F3 1 Tf
0.5634 0 TD
[(m)-208.8(n)0(y)15.5(l)13.9(on)-200.7(ga)20.8(uz)15.1(e)-206(\()0(C)20.6(u)0(r)13.9(a)0(p)20.8(h)0(a)15.1(r)0(m)]TJ
-12.2005 -1.0471 TD
[(24)15.5(9.)21.6(1)-501.5(f)0(i)17.3(l)0(t)16.5(e)0(r)19.2(;)-503.9(Ma)13.2(xx)21.2(im)-496.4(Me)18.9(di)18.9(ca)14.7(l)-503.9(E)12.2(ur)13.9(op)21.2(e,)-496.6(D)12.4(e)0(n)-497(B)11.6(ar)13.5(ch)20.8(,)-501.2(t)0(h)13.2(e)]TJ
0 -1.0527 TD
[(Ne)16.9(th)18.8(er)13.5(la)18.4(nd)21.2(s\))-237.6(an)15.1(d)-239.8(r)0(e)13.5(c)0(o)20.8(v)0(e)15.1(r)0(y)-236.4(a)0(n)20.8(d)-245.5(as)19.6(pe)15.1(ct)-231.9(we)16.9(re)-236.8(as)13.9(se)19.6(ss)18.9(ed)15.1(.)-239.4(T)0(h)17.1(e)0(y)]TJ
0 -1.0471 TD
[(we)16.9(re)-259.6(th)18.9(en)-258(ce)20.4(nt)13.2(ri)17.3(fu)19.6(ge)15.1(d)-262.5(f)0(o)13.9(r)-264.1(5)-262.5(m)0(i)15.7(n)-268.2(at)-254.7(40)15.5(0)]TJ
/F9 1 Tf
15.1596 0 TD
(6)Tj
/F4 1 Tf
0.9958 0 TD
(g)Tj
/F3 1 Tf
0.7625 0 TD
[(at)-260.4(4)]TJ
/F9 1 Tf
1.4568 0 TD
(8)Tj
/F3 1 Tf
0.3756 0 TD
[(C,)-256.2(an)15.1(d)-262.5(t)0(h)13.2(e)]TJ
-18.7504 -1.0527 TD
[(su)20(pe)15.1(rn)19.6(at)12.8(an)20.8(ts)-261.2(we)16.9(re)-259.6(de)15.1(ca)20.4(nt)13.2(ed)-258(an)15.1(d)-268.2(s)0(t)17.7(o)0(r)19.6(e)0(d)-263.7(i)0(n)-260(E)12.2(pp)15.5(en)20.8(do)15.5(rf)-260.8(tu)18.8(be)15.1(s)]TJ
0 -1.0471 TD
[(at)-283.1(-8)13.9(0)]TJ
/F9 1 Tf
2.2876 0 TD
(8)Tj
/F3 1 Tf
0.3756 0 TD
[(C.)-284.7(T)12.2(h)0(e)-286.5(c)0(e)20.4(l)0(l)-285.1(p)0(e)15.1(l)0(l)22.2(e)0(t)-288.8(w)12.4(as)-287.7(re)19.2(su)20(sp)14.4(en)20.8(de)15.1(d)-291(i)0(n)-282.7(F)79.7(AC)18.3(S)-295.9(b)0(u)21.2(f)20.4(fe)13.5(r)]TJ
-2.6632 -1.0527 TD
[(an)15.1(d)-404.8(c)0(e)20.4(n)0(t)18.9(r)0(i)17.3(f)0(u)13.9(g)0(e)20.8(d)-404.8(ag)15.1(ai)18.5(n)-404.8(f)0(o)13.9(r)-400.7(5)-410.5(m)13.2(in)-396.6(at)-397(40)15.5(0)]TJ
/F9 1 Tf
16.0929 0 TD
(6)Tj
/F4 1 Tf
0.9958 0 TD
(g)Tj
/F3 1 Tf
0.9048 0 TD
[(at)-397(4)]TJ
/F9 1 Tf
1.5934 0 TD
(8)Tj
/F3 1 Tf
0.3756 0 TD
[(C.)-398.5(T)12.2(h)0(e)]TJ
-19.9624 -1.0471 TD
[(su)20(pe)15.1(rn)19.6(at)12.8(an)20.8(t)-350.3(f)0(r)18(o)0(m)-346.1(t)0(h)18.9(e)-348.3(se)13.9(co)20.8(nd)-343(ce)20.4(nt)13.2(ri)17.3(fu)19.6(ga)15.1(ti)22.2(on)-343(wa)16.9(s)-349.1(a)0(s)13.9(p)0(i)18.9(r)0(a)19.2(t)0(e)12.8(d)]TJ
0 -1.0527 TD
[(an)15.1(d)-365(t)0(h)18.9(e)-365.4(ce)14.7(ll)-359.1(pe)20.8(ll)16.5(et)-357.1(re)13.5(su)20(sp)20(en)15.1(de)20.8(d)-370.7(i)0(n)-356.7(F)85.4(AC)12.6(S)-364.2(b)0(u)15.5(f)20.4(fe)13.5(r)-366.6(f)0(o)19.6(r)-366.6(TC)18.1(C)]TJ
0 -1.0471 TD
[(de)15.1(te)18.4(rm)16.5(in)18.8(at)18.5(io)18.9(n,)-336.9(vi)18.9(ab)15.1(i)13.9(l)0(i)16.5(t)0(y)-334(a)0(s)14(s)0(e)19.6(s)0(s)18.9(m)0(e)12(n)0(t)-328.3(a)0(n)15.1(d)-342.2(cy)15.1(to)18.9(sp)20(in)-334(pr)13.9(ep)20.8(ar)13.5(a-)]TJ
0 -1.0527 TD
[(ti)16.5(on)-451.1(\(t)17.3(he)-451.5(cy)15.1(to)18.9(sp)14.4(i)13.9(n)-461.7(ce)14.7(nt)18.9(ri)17.3(fu)13.9(ga)20.8(ti)16.5(on)-451.1(st)17.7(ep)-451.5(wa)11.2(s)-457.2(p)0(e)15.1(r)0(f)18(o)0(r)19.6(m)0(e)12(d)-461.7(at)]TJ
0 -1.0471 TD
(34)Tj
/F9 1 Tf
0.9845 0 TD
(6)Tj
/F4 1 Tf
0.9902 0 TD
(g)Tj
/F3 1 Tf
0.4894 0 TD
0.3666 Tc
[(\)\()366.6(s)385(e)366.6(e)]TJ
/F4 1 Tf
2.612 0 TD
0 Tc
[(Sp)21.2(ut)13.2(um)-358.3(pr)54.2(oc)15.1(es)19.6(si)17.7(ng)]TJ
/F3 1 Tf
7.4888 0 TD
[(\).)-355.6(Ce)16.1(ll)-359.1(co)20.8(un)15.5(ti)16.5(ng)21.2(,)-370.3(c)0(y)20.8(t)0(o)18.9(s)0(p)14.4(i)0(n)]TJ
-12.5647 -1.0527 TD
[(st)17.7(ai)18.4(ni)18.9(ng)-496.6(an)20.8(d)-507.2(e)0(x)20.8(p)0(r)19.6(e)0(s)13.9(s)0(i)17.7(o)0(n)-490.9(o)0(f)-492.5(B)0(W)-422.8(a)0(n)15.1(d)-501.5(BA)18.3(L)-505.7(r)0(e)19.2(s)0(u)14.3(l)0(t)16.5(s)-497(we)11.2(re)]TJ
0 -1.0471 TD
[(pe)15.1(rf)18(or)19.6(me)17.7(d)-325.1(a)0(s)-316.1(f)0(o)19.6(r)-326.7(in)18.9(du)15.5(ce)20.4(d)-325.1(s)0(p)14.3(u)0(t)18.9(u)0(m)18.1(.)]TJ
/F4 1 Tf
0 -3.1583 TD
[(Biopsy)-342.7(sample)-336.8(pr)25.7(ocessing)-341.7(and)-332.3(cell)-338.7(quanti)-9.3(ficatio)-9.6(n)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(Th)17.1(e)-416.6(b)0(i)18.9(o)0(p)21.2(s)0(y)-406.7(s)0(a)13.9(m)0(p)18.1(l)0(e)18.4(s)-411.7(we)11.2(re)-401.9(em)12(be)20.8(dd)15.5(ed)-406(in)-402.3(T)40.6(i)0(s)17.7(s)0(u)14.3(e)-410.9(T)69.1(e)0(k)]TJ
/F5 1 Tf
20.799 0 TD
(1)Tj
/F3 1 Tf
-21.8005 -1.0471 TD
[(op)15.5(ti)22.2(ma)12(l)-344.6(c)0(u)15.1(t)0(t)16.5(i)13.9(ng)-343(te)18.4(mp)18.1(er)19.2(at)12.8(ur)19.6(e)-348.3(m)0(e)17.7(d)0(i)18.9(u)0(m)-340.4(\()0(B)14.9(a)0(y)20.8(e)0(r)-339.3(C)0(o)16.5(r)0(p)13.9(o)0(r)19.6(a)0(t)18.4(i)0(o)18.9(n)0(,)]TJ
0 -1.0527 TD
[(El)14.7(kh)21.2(ar)13.5(t)13.9(,)-358.9(IN)15.7(,)-353.2(U)0(S)18.1(A)0(\))15.7(,)-353.2(an)15.1(d)-353.6(s)0(n)14.4(a)0(p)20.8(-)0(f)18(r)0(o)13.9(z)0(e)20.4(n)-359.3(in)-345.3(li)16.5(qu)21.2(id)-351(is)17.7(op)21.2(en)15.1(ta)18.4(ne)15.1(.)]TJ
0 -1.0471 TD
-0.0121 Tc
[(Sa)-12.1(mp)-12.1(l)6.8(e)-12.1(s)-487.5(w)-12.1(er)-12.1(e)-487.9(s)-12.1(t)5.6(o)-12.1(r)7.5(e)-12.1(d)-492(a)-12.1(t)-488.7(-)-12.1(80)]TJ
/F9 1 Tf
11.5006 0 TD
0 Tc
(8)Tj
/F3 1 Tf
0.3756 0 TD
[(C)-489.2(u)0(n)15.5(t)13.9(il)-478.6(fu)13.9(rt)17.3(he)20.8(r)-491.7(p)0(r)19.6(o)0(c)15.1(e)0(s)19.6(s)0(i)17.7(n)0(g)15.5(.)]TJ
-11.8762 -1.0528 TD
[(F)11.4(r)0(o)13.9(z)0(e)20.4(n)-410.5(bi)13.2(op)21.2(si)17.7(es)-401.5(we)16.9(re)-401.9(th)13.2(en)-400.3(cu)20.8(t)-412.9(s)0(e)13.9(r)0(i)17.3(a)0(l)18.5(l)0(y)81.4(,)-410.1(an)20.8(d)-410.5(d)0(i)13.2(v)0(i)18.9(d)0(e)20.8(d)-410.5(in)13.2(to)]TJ
0 -1.0471 TD
[(se)19.6(ri)17.3(es)-230.7(of)-230.7(19)-223.5(se)13.9(ct)18.5(io)18.9(ns)-230.3(\(4)19.6(-)]TJ
/F8 1 Tf
9.1845 0 TD
(m)Tj
/F3 1 Tf
0.5634 0 TD
[(m)-237.2(t)0(h)13.2(i)0(c)18.4(k)0(\))-225.1(a)0(n)15.1(d)-234.1(st)17.7(or)14(ed)-229.6(at)-226.2(-2)19.6(0)]TJ
/F9 1 Tf
9.9983 0 TD
(8)Tj
/F3 1 Tf
0.3756 0 TD
0.2388 Tc
[(Cu)238.8(n)260(t)238.8(i)255.3(l)]TJ
-20.1218 -1.0527 TD
0 Tc
[(us)20(e.)-382.8(Mo)19.3(rp)13.9(ho)21.2(lo)13.2(gi)18.9(ca)20.4(ll)16.5(y)-393.4(o)0(p)21.2(t)0(i)16.5(m)0(a)17.7(l)-390.1(ti)16.5(ss)18.9(ue)-383.2(wa)16.9(s)-388.9(s)0(e)13.9(l)0(e)18.4(c)0(t)18.5(e)0(d)-383.2(o)0(n)-377.1(t)0(h)13.2(e)]TJ
0 -1.0471 TD
[(ba)15.1(si)17.7(s)-201.1(o)0(f)-190.9(a)-200.3(ha)15.1(em)17.7(at)18.5(ox)15.5(yl)18.9(in)-191.7(an)15.1(d)-199.9(e)0(o)15.1(s)0(i)17.7(n)0(-)19.6(s)0(t)17.7(a)0(i)18.4(n)0(e)15.1(d)-199.9(sl)17.7(id)18.9(e.)-195(S)11.4(e)0(c)14.7(t)0(i)16.5(o)0(n)21.2(s)-206.8(\(4)]TJ
/F8 1 Tf
0 -1.0528 TD
(m)Tj
/F3 1 Tf
0.5634 0 TD
[(m\))-273.7(w)12.4(e)0(r)13.5(e)-280(ai)18.4(r)20.4(-)0(d)19.6(r)0(i)17.3(e)0(d)-269.4(f)0(o)13.9(r)-275.5(20)-269(mi)15.7(n)-279.6(a)0(n)15.1(d)-273.9(fi)17.3(xe)15.1(d)-279.6(i)0(n)-265.7(a)0(c)14.7(e)0(t)18.5(o)0(n)15.5(e)-274.3(fo)13.9(r)-275.5(1)0(0)]TJ
-0.5634 -1.0471 TD
[(mi)15.7(n.)-308.4(Im)16.5(mu)18.1(no)15.5(hi)18.9(st)17.7(oc)15.1(he)20.8(mi)15.7(ca)14.7(l)-316.1(s)0(t)17.7(a)0(i)18.4(n)0(i)18.9(n)0(g)-308.8(w)0(a)16.9(s)-320.6(pe)15.1(rf)18(or)19.6(me)17.7(d)-319.4(u)0(s)20(i)0(n)13.2(g)]TJ
0 -1.0527 TD
[(mo)18.1(no)15.5(cl)18.5(on)15.5(al)-340.1(an)20.8(ti)16.5(bo)15.5(di)18.9(es)-344.6(di)18.9(re)19.2(ct)18.4(ed)-343.4(ag)15.1(ai)18.4(ns)20(t)-350.3(t)0(h)18.9(e)-354(se)19.6(cr)13.5(et)18.5(ed)-337.7(fo)13.9(rm)]TJ
0 -1.0471 TD
[(of)-282(EC)18.1(P)-290.2(\()0(E)15.5(G)0(2)17.3(,)-290.6(1:)18.9(50)15.5(;)-287.7(S)0(a)15.9(n)0(b)15.5(i)0(o)18.9(,)-290.6(Ud)17.3(en)20.8(,)-290.6(t)0(h)13.2(e)-285.7(Ne)11.2(t)13.9(h)0(e)15.1(r)0(l)17.3(a)0(n)15.1(d)0(s)20(\))0(,)-281.6(n)0(e)15.1(u)0(-)]TJ
0 -1.0527 TD
[(tr)17.3(op)15.5(hi)18.9(l)-492.5(e)0(l)18.5(a)0(s)13.9(t)13.9(a)0(s)13.9(e)-490.6(\(N)15.7(P5)16.3(7,)-484.8(1:)18.9(40)15.5(;)-492.5(D)12.4(ak)15.1(o,)-484.8(C)11.6(o)0(p)15.5(e)0(n)15.1(h)0(a)20.8(g)0(e)15.1(n)0(,)-479.2(D)0(e)16.9(n)0(-)]TJ
0 -1.0471 TD
[(ma)17.7(rk)13.9(\),)-196.2(C)11.6(D)0(3)-198.9(\()0(1)19.6(:)0(5)13.2(0)0(;)-191.7(B)0(e)16.1(c)0(t)18.5(o)0(n)15.5(-)0(D)15.7(i)0(c)18.4(k)0(i)18.9(n)0(s)14.4(o)0(n)21.2(,)-205.2(Sa)15.9(n)-205.6(J)0(o)20(s)0(e)13.9(,)-199.6(CA)12.6(,)-205.2(U)0(S)18.1(A)0(\))]TJ
0 -1.0527 TD
[(an)15.1(d)-302.4(C)11.6(D6)17.3(8)-302.4(\()0(1)13.9(:)0(5)18.9(0)0(0)21.2(;)-304.7(Da)16.9(ko)15.5(\))-298.3(f)0(o)13.9(r)-304(th)18.9(e)-302.8(d)0(e)20.8(t)0(e)12.8(c)0(t)18.4(i)0(o)18.9(n)-302.4(of)-293.3(eo)15.1(si)17.7(no)21.2(ph)15.5(il)16.5(s,)]TJ
0 -1.0471 TD
[(ne)15.1(ut)18.9(ro)19.6(ph)15.5(il)16.5(s,)-440.5(ly)18.9(mp)18.1(ho)15.5(cy)20.8(te)12.8(s)-451.5(a)0(n)20.8(d)-450.3(ma)12(cr)19.2(op)15.5(ha)20.8(ge)15.1(s)-451.5(r)0(e)19.2(s)0(p)20(e)0(c)14.7(t)0(i)16.5(v)0(e)20.8(l)0(y)75.8(.)]TJ
0 -1.0528 TD
[(De)16.9(te)18.4(ct)18.4(io)13.2(n)-325.1(o)0(f)-316.1(t)0(h)18.9(e)-325.5(pr)13.9(im)15.7(ar)19.2(y)-325.1(a)0(n)15.1(t)0(i)16.5(b)0(o)21.2(d)0(i)18.9(e)0(s)-321.8(w)12.4(as)-321.8(pe)20.8(rf)18(or)13.9(me)17.7(d)-325.1(u)0(s)20(i)0(n)13.2(g)]TJ
0 -1.0471 TD
[(sp)20(ec)14.7(if)17.3(ic)-499.4(bi)18.9(ot)13.2(in)18.9(yl)18.9(at)18.4(ed)-502.7(ra)19.2(bb)15.5(it)-501.4(an)20.8(ti)16.5(mo)18.1(us)14.4(e)-507.6(i)0(m)15.7(m)0(u)18.1(n)0(o)15.5(g)0(l)18.9(o)0(b)21.2(u)0(l)13.2(i)0(n)18.9(s)]TJ
0 -1.0528 TD
[(\(1)19.6(:3)13.2(00)21.2(\))-235.7(a)0(n)15.1(d)-234.1(su)20(bs)14.4(eq)20.8(ue)15.1(nt)18.9(ly)-225.8(st)17.7(re)13.5(pt)18.9(av)20.8(id)13.2(i)13.9(n)-239.8(co)20.8(nj)18.9(ug)15.5(at)18.5(ed)-229.6(to)-225.8(ho)21.2(rs)12.8(e-)]TJ
0 -1.0471 TD
[(ra)19.2(di)13.2(sh)-634.4(pe)20.8(ro)13.9(xi)18.9(da)20.8(se)-634.8(\(1)13.9(:3)18.9(00)15.5(\),)-634.4(pr)19.6(ov)15.5(i)13.9(d)0(i)13.2(n)0(g)-633.2(a)-644.2(re)19.2(dd)15.5(is)17.7(h-)19.6(br)14(ow)17.3(n)]TJ
0 -1.0528 TD
[(pr)19.6(od)15.5(uc)15.1(t)13.9(.)-239.4(Hy)17.3(dr)13.9(og)21.2(en)-229.6(pe)15.1(ro)19.6(xi)18.9(de)-229.6(\(1)13.9(:1)18.9(00)15.5(\))-235.7(w)0(a)16.9(s)-241(us)20(ed)-229.6(to)-231.5(bl)18.9(oc)15.1(k)-234.1(e)0(n)15.1(-)]TJ
0 -1.0471 TD
[(do)15.5(ge)20.8(no)15.5(us)-241.7(pe)20.8(ro)13.9(xi)18.9(da)15.1(se)-242.1(an)20.8(d)-251.2(h)0(a)15.1(e)0(m)17.7(a)0(t)18.4(o)0(x)15.5(y)0(l)18.9(i)0(n)-242.9(w)0(a)16.9(s)-252.3(us)20(ed)-246.6(as)-242.1(co)20.8(un)15.5(-)]TJ
0 -1.0528 TD
[(te)18.4(rs)18.4(ta)12.8(in)18.9(.)-307.7(F)11.4(or)-304.7(ea)20.4(ch)-297.8(an)15.1(ti)16.5(bo)21.2(dy)78.1(,)-307.7(t)0(h)18.9(e)-308.5(to)13.2(ta)18.4(l)-310.4(n)0(u)21.2(m)0(b)18.1(e)0(r)-305.1(o)0(f)-299(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)15.1(l)0(y)]TJ
0 -1.0471 TD
[(st)17.7(ai)18.4(ne)15.1(d)-347.9(c)0(e)14.7(l)0(l)22.2(s)-354.8(w)12.4(a)0(s)-344.6(c)0(o)20.8(u)0(n)15.5(t)0(e)18.4(d)-347.9(to)-345.3(a)-348.3(d)0(e)20.8(p)0(t)13.2(h)-347.9(of)-338.9(10)15.5(0)]TJ
/F8 1 Tf
17.9366 0 TD
(m)Tj
/F3 1 Tf
0.5634 0 TD
0.351 Tc
[(mb)351(e)366.1(l)351(o)369.8(w)-0.8(a)]TJ
-18.5 -1.0527 TD
0 Tc
[(ra)19.2(nd)15.5(om)18.1(ly)-584.3(se)13.9(le)18.4(ct)18.4(ed)-588.1(1-)19.6(mm)]TJ
7.472 0 0 6.641 161.575 232.044 Tm
(2)Tj
9.963 0 0 9.963 171.213 227.622 Tm
[(ar)13.5(ea)-582.8(of)-583.6(ep)15.1(it)16.5(he)20.8(li)16.5(al)-584.8(ba)15.1(se)19.6(me)12(nt)]TJ
-11.3356 -1.0471 TD
[(me)17.7(mb)12.4(ra)19.2(ne)20.8(.)-353.2(S)0(l)13.9(i)0(d)18.9(e)0(s)-344.6(w)0(e)16.9(r)0(e)-345(c)0(o)15.1(d)0(e)20.8(d)-353.6(an)15.1(d)-353.6(c)0(o)20.8(u)0(n)15.5(t)0(e)18.4(d)-353.6(tw)14.9(ic)18.4(e)-354(b)0(y)-343(o)0(n)15.5(e)]TJ
0 -1.0528 TD
[(ob)15.5(se)19.6(rv)19.6(er)-310.8(in)-305.5(a)-319.8(b)0(l)18.9(i)0(n)18.9(d)0(e)15.1(d)-313.7(fa)13.5(sh)20(io)18.9(n.)-308.4(Th)17.1(e)-314.2(m)0(e)12(a)0(n)-303.5(v)0(a)15.1(l)0(u)18.9(e)-314.2(wa)11.2(s)-314.9(t)0(a)18.4(k)0(e)15.1(n)]TJ
0 -1.0471 TD
[(fo)19.6(r)-508.8(a)0(n)20.8(a)0(l)12.8(y)0(s)20(i)0(s)17.7(.)-506.8(L)12.2(i)0(g)18.9(h)0(t)-499(m)0(i)15.7(c)0(r)19.2(o)0(s)14.4(c)0(o)20.8(p)0(y)-496.6(w)0(a)16.9(s)-502.7(pe)15.1(rf)18(or)13.9(me)17.7(d)-501.5(u)0(s)14.4(i)0(n)18.9(g)-507.2(a)]TJ
0 -1.0528 TD
[(Ze)16.7(is)17.7(s)-275.1(m)0(i)15.7(c)0(r)19.2(o)0(s)20(c)0(o)15.1(p)0(e)-263.7(s)0(e)13.9(t)-270.6(at)-266.1(a)-274.3(m)0(a)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.4(a)0(t)18.4(i)0(o)18.9(n)-273.9(of)]TJ
/F9 1 Tf
16.844 0 TD
(6)Tj
/F3 1 Tf
0.9958 0 TD
[(20)21.2(0)-273.9(f)0(o)19.6(r)-275.5(EG)13.2(2)]TJ
-17.8399 -1.0471 TD
[(an)15.1(d)]TJ
/F9 1 Tf
1.7413 0 TD
(6)Tj
/F3 1 Tf
0.9958 0 TD
[(40)21.2(0)-325.1(f)0(o)19.6(r)-326.7(ne)15.1(ut)18.9(ro)19.6(ph)15.5(il)-313.6(el)18.4(as)14(ta)18.4(se)19.6(,)-324.7(C)0(D)18.3(3)-325.1(an)15.1(d)-325.1(C)11.6(D6)17.3(8.)]TJ
/F4 1 Tf
-2.7372 -3.1583 TD
[(Biochem)-10.9(ical)-338.3(assays)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(Th)17.1(e)-405.2(c)0(o)15.1(n)0(c)20.8(e)0(n)15.1(t)0(r)17.3(a)0(t)18.4(i)0(o)18.9(n)-410.5(of)-395.8(EC)18.1(P)-409.7(i)0(n)-396.6(s)0(p)14.4(u)0(t)18.9(u)0(m)-397.3(s)0(u)20(p)0(e)15.1(r)0(n)19.6(a)0(t)12.8(a)0(n)20.8(t)-407.2(an)15.1(d)]TJ
-1.0015 -1.0471 TD
[(BW)-183.8(an)20.8(d)-262.5(B)0(A)12.6(L)-261(fl)17.3(ui)18.9(d)-262.5(w)0(a)16.9(s)-263.7(me)17.7(as)19.6(ur)13.9(ed)-252.3(us)20(in)13.2(g)-256.8(t)0(h)13.2(e)-262.9(fl)17.3(uo)21.2(ro)13.9(en)20.8(zy)15.1(me)]TJ
25.1977 66.1583 TD
[(im)15.7(mu)12.4(no)21.2(as)19.6(sa)13.9(y)-541.4(\()0(I)18(m)0(m)14.9(u)0(n)15.5(o)0(C)16.5(A)0(P)-533.9(E)0(C)18.1(P)108.1(,)-541(P)11.4(ha)15.1(rm)16.5(ac)14.7(i)13.9(a)0(,)-536.5(U)0(p)17.3(p)0(s)14.3(a)0(l)18.5(a)0(,)]TJ
0 -1.0755 TD
[(Sw)12.4(ed)20.8(en)15.1(\).)-224.7(IL)21.2(-8)-225.1(wa)16.9(s)-235.3(m)0(e)17.7(a)0(s)13.9(u)0(r)19.6(e)0(d)-223.9(u)0(s)14.4(i)0(n)18.9(g)-234.1(a)-234.5(h)0(u)21.2(m)0(a)17.7(n)-234.1(IL)15.5(-8)-225.1(en)20.8(zy)15.1(me)17.7(-)]TJ
T*
[(li)16.5(nk)15.5(ed)-354.7(im)15.7(mu)18.1(no)15.5(so)20(rb)13.9(en)20.8(t)-367.3(a)0(s)19.6(s)0(a)14(y)-365(\(E)15.5(L)12.2(I)0(S)14.7(A)0(\))-359.9(\()0(A)15.7(m)0(e)17.7(r)0(s)18.4(h)0(a)15.1(m)0(,)-357.1(L)12.2(it)16.5(tl)16.5(e)]TJ
T*
[(Ch)16.5(al)12.8(fo)19.6(nt)18.9(,)-324.7(U)0(K)19.1(\))0(.)]TJ
/F4 1 Tf
0 -4.046 TD
[(Stat)-7.8(istics)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(Cl)14.1(in)18.8(ic)18.4(al)-425.4(ch)20.8(ar)13.5(ac)20.4(te)12.8(ri)17.3(st)17.7(ic)18.4(s)-428.7(a)0(r)13.5(e)-428(pr)19.6(es)13.9(en)20.8(te)12.8(d)-427.6(a)0(s)-424.2(m)0(e)17.7(a)0(n)20.8(\213)]TJ
6.974 0 0 6.974 509.216 678.274 Tm
0.0001 Tc
(SD)Tj
9.963 0 0 9.963 522.312 678.274 Tm
0 Tc
[(an)15.1(d)]TJ
-21.3794 -1.0755 TD
[(ce)14.7(ll)-467.2(ch)20.8(ar)13.5(ac)20.4(te)12.8(ri)17.3(st)17.7(ic)18.4(s)-474.3(a)0(s)-469.8(m)0(e)17.7(d)0(i)18.9(a)0(n)15.1(s)-474.3(wi)14.9(th)-464.8(ra)19.2(ng)15.5(es)19.6(.)-478.4(D)12.4(if)22.9(fe)19.2(re)19.2(nc)15.1(es)]TJ
T*
[(be)15.1(tw)14.9(ee)20.4(n)-399.1(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)-386.4(w)0(i)14.9(t)0(h)-385.2(C)0(O)12.6(P)11.4(D)-397.4(a)0(n)15.1(d)-393.4(he)15.1(al)18.4(th)18.9(y)-393.4(s)0(u)14.4(b)0(j)18.9(e)0(c)14.7(t)0(s)-386.4(w)0(e)16.9(r)0(e)]TJ
T*
[(te)12.8(st)17.7(ed)-525.5(us)20(in)13.2(g)-535.7(t)0(h)18.9(e)-536.1(Ma)13.2(nn)21.2(-W)12.8(hi)18.9(tn)18.8(ey)-525.5(U-)15.7(te)12.8(st)-522.9(an)15.1(d)-535.7(d)0(i)18.9(f)14.7(fe)19.2(re)19.2(nc)15.1(es)]TJ
T*
[(wi)14.9(th)18.9(in)-231.5(gr)13.9(ou)21.2(ps)-236(us)20(in)18.8(g)-239.8(t)0(h)13.2(e)-240.2(W)37.9(i)13.9(lc)12.8(ox)21.2(on)-234.8(ma)17.7(tc)18.5(he)15.1(d-)19.6(pa)15.1(ir)17.3(s)-241(t)0(e)18.4(s)0(t)17.7(.)-239.4(Co)16.5(r)20.4(-)]TJ
T*
[(re)13.5(la)18.4(ti)16.5(on)-246.2(be)15.1(tw)20.6(ee)14.7(n)-256.8(c)0(e)14.7(l)13.9(l)-259.2(v)0(a)15.1(r)0(i)17.3(a)0(b)20.8(l)0(e)12.8(s)-252.3(we)16.9(re)-253.9(an)20.8(al)18.5(ys)14.3(ed)-246.6(us)20(in)13.2(g)-256.8(S)11.4(pe)15.1(ar)30.6(-)]TJ
T*
[(ma)12(n)]TJ
/F9 1 Tf
1.6844 0 TD
(')Tj
/F3 1 Tf
0.2106 0 TD
[(s)-252.3(r)0(a)19.2(n)0(k)-246.2(c)0(o)15.1(r)0(r)18(e)0(l)18.5(a)0(t)18.4(i)0(o)13.2(n)-251.2(co)15.1(ef)30.6(fi)17.3(ci)18.5(en)15.1(t.)-242.5(Di)14.9(f)20.4(f)0(e)13.5(r)0(e)19.2(n)0(t)18.9(i)0(a)12.8(l)-253.5(sp)20(ut)18.9(um)-249.4(ce)20.4(ll)]TJ
-1.895 -1.0755 TD
[(co)15.1(un)15.5(t)13.9(s)-343.4(\(e)19.2(xp)15.5(re)19.2(ss)18.8(ed)-332(as)-333.2(a)-336.9(p)0(e)15.1(r)0(c)19.2(e)0(n)15.1(t)13.9(ag)15.1(e)-336.9(o)0(f)-333.2(n)0(o)15.5(n)0(s)20(q)0(u)15.5(a)0(m)17.7(o)0(u)21.2(s)-343.4(ce)20.4(ll)16.5(s\))]TJ
T*
[(an)15.1(d)-353.6(a)0(b)20.8(s)0(o)14.4(l)0(u)18.9(t)0(e)-340.1(c)0(e)14.7(l)0(l)-342(n)0(u)15.5(m)0(b)18.1(e)0(r)19.2(s)-354.8(in)-345.3(sp)20(ut)18.9(um)-346.1(\(e)19.2(xp)15.5(re)19.2(ss)18.9(ed)-343.4(in)-345.3(ce)20.4(ll)16.5(s)]TJ
/F11 1 Tf
22.5289 0.2049 TD
(.)Tj
/F3 1 Tf
-22.5289 -1.2804 TD
(mL)Tj
7.472 0 0 6.641 322.866 586.318 Tm
(-1)Tj
9.963 0 0 9.963 328.819 581.839 Tm
[(\))-252.7(w)0(e)11.2(r)0(e)-242.5(u)0(s)14.4(e)0(d)-240.9(i)0(n)-248.6(t)0(h)18.8(e)-257.2(co)20.8(mp)12.4(ar)19.2(is)17.7(on)-246.2(of)-247.8(B)11.6(W)-184(an)15.1(d)-251.2(B)0(A)12.6(L)-255.3(fl)17.3(ui)18.8(d,)]TJ
-1.9576 -1.0698 TD
[(an)15.1(d)-268.2(a)0(b)20.8(s)0(o)14.4(l)0(u)18.9(t)0(e)-254.7(c)0(e)14.7(l)0(l)-256.7(n)0(u)15.5(m)0(b)18.1(e)0(r)19.2(s)-269.4(we)16.9(re)-259.6(us)20(ed)-258(in)-260(th)18.9(e)-268.6(c)0(o)20.8(m)0(p)12.4(a)0(r)19.2(i)0(s)17.7(o)0(n)-257.6(o)0(f)]TJ
0 -1.0755 TD
[(in)13.2(fl)17.3(am)17.7(ma)17.7(to)18.8(ry)-247.8(ce)20.4(ll)-245.3(co)15.1(un)21.2(ts)-244.1(in)-242.9(in)13.2(du)21.2(ce)14.7(d)-251.2(s)0(p)20(u)0(t)13.2(u)0(m)-243.7(a)0(n)20.8(d)-256.8(br)19.6(on)15.5(ch)20.8(ia)18.5(l)]TJ
T*
[(bi)13.2(op)21.2(sy)-406.7(sa)19.6(mp)18.1(le)12.8(s.)-400.7(A)-414.4(p)0(-)13.9(v)0(a)20.8(l)0(u)13.2(e)]TJ
/F8 1 Tf
11.273 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(05)-405.6(wa)16.9(s)-417.4(c)0(o)20.8(n)0(s)20(i)0(d)13.2(e)0(r)19.2(e)0(d)-406(s)0(t)17.7(a)0(t)18.5(i)0(s)17.7(-)]TJ
-11.8193 -1.0755 TD
[(ti)16.5(ca)14.7(ll)16.5(y)-581.2(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.4(a)0(n)20.8(t)0(.)-578.3(A)0(l)20.6(l)-583.6(an)15.1(al)18.5(ys)14.4(es)-572.2(we)16.9(re)-578.3(pe)20.8(rf)18(or)14(me)17.7(d)-581.2(u)0(s)14.4(i)0(n)18.8(g)]TJ
T*
[(SP)17.1(SS)-318.6(6.)21.6(0)-325.1(f)0(o)19.6(r)-326.7(W)37.9(i)0(n)18.9(d)0(o)15.5(w)12.4(s)-326.3(\()0(S)14.7(P)11.4(SS)17.1(,)-324.7(I)0(n)19.6(c)0(.)15.5(,)-319.1(Ch)16.5(ic)12.8(ag)20.8(o,)-314.1(IL)15.5(,)-324.7(U)12.4(SA)12.4(\).)]TJ
/F6 1 Tf
9.8617 -4.0517 TD
[(Res)-7.8(ults)]TJ
/F3 1 Tf
-8.8602 -2.0998 TD
[(T)69.1(w)0(o)-324.1(s)0(u)14.4(b)0(j)18.9(e)0(c)14.7(t)13.9(s)-337.7(w)0(i)14.9(t)13.9(h)-336.5(C)0(O)18.3(P)0(D)-329(d)0(i)18.9(d)-336.5(no)21.2(t)-333.2(y)0(i)18.9(e)0(l)12.8(d)-330.8(su)14.4(f)20.4(f)0(i)17.3(c)0(i)18.4(e)0(n)15.1(t)-333.2(fl)17.3(ui)18.8(d)]TJ
-1.0015 -1.0755 TD
[(an)15.1(d)-313.8(b)0(i)18.9(o)0(p)15.5(s)0(y)-304.3(s)0(a)14(m)0(p)18.1(l)0(e)-305.9(f)0(o)13.9(r)-315.3(di)18.9(f)20.4(f)0(e)19.2(r)0(e)13.5(n)0(t)18.9(i)0(a)18.4(l)-316.1(ce)14.7(ll)-307.9(co)20.8(un)15.5(ti)16.5(ng)-303.1(an)15.1(d)-313.8(w)0(e)16.9(r)0(e)]TJ
T*
[(ex)15.1(cl)18.4(ud)15.5(ed)-314.9(fr)18(om)-317.7(th)18.9(e)-325.5(a)0(n)15.1(a)0(l)18.5(y)0(s)20(e)0(s)13.9(.)-319(On)17.3(e)-325.5(h)0(e)15.1(a)0(l)18.5(t)0(h)18.9(y)-325.1(su)14.4(bj)18.9(ec)20.4(t)-327.5(w)0(a)16.9(s)-326.3(un)21.2(-)]TJ
T*
[(wi)14.9(ll)16.5(in)18.8(g)-376.3(t)0(o)-362.4(u)0(n)15.5(d)0(e)15.1(r)20.4(go)-365.7(br)19.6(on)15.5(ch)20.8(os)14.4(co)20.8(py)78.1(.)-370.3(T)0(h)17.1(e)-376.7(cl)18.4(in)18.8(ic)12.8(al)-362.8(ch)15.1(ar)19.2(ac)14.7(te)18.5(r)20.4(-)]TJ
0 -1.0698 TD
[(is)17.7(ti)16.5(cs)-407.2(of)-401.5(th)18.8(e)-416.6(r)0(e)19.2(m)0(a)17.7(i)0(n)18.9(i)0(n)13.2(g)-410.5(29)-399.9(su)14.4(bj)18.9(ec)14.7(ts)-403.4(ar)19.2(e)-410.9(l)0(i)16.5(s)0(t)17.7(e)0(d)-406(i)0(n)-402.2(t)0(a)18.5(b)0(l)18.9(e)-416.6(1.)]TJ
0 -1.0755 TD
[(T)57.7(welve)-415(subje)-7.8(cts)-416(with)-415.8(COPD)-418.9(had)-418.1(received)-421.4(maintenan)-10.3(ce)]TJ
T*
[(treat)-11(ment)-418.7(with)-415.8(inhal)-9(ed)-417.3(corticosteroi)-13.6(ds)-418.1(before)-418.3(the)-414.8(study)55.2(.)]TJ
T*
[(Ni)-7.8(ne)-212.5(subje)-7.8(cts)-216.8(wi)-7.8(th)-214.5(COPD)-225.4(and)-213.2(one)-218.9(healt)-9.4(hy)-212.1(subje)-7.8(ct)-220.6(yielded)]TJ
T*
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[(sp)14.4(ut)18.9(um)-477(an)15.1(d)-484.5(B)0(A)12.6(L)-488.6(fl)17.3(ui)18.9(d)-484.5(i)0(n)-481.9(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)-477.4(w)0(i)14.9(t)0(h)-476.2(C)0(O)12.6(P)11.4(D)-488.4(n)0(o)15.5(r)-486.1(in)]TJ
0 -1.0528 TD
[(he)15.1(al)18.4(th)18.9(y)-325.1(s)0(u)14.4(b)0(j)18.8(e)0(c)20.4(t)0(s)17.7(.)]TJ
0 -1.0471 TD
[(Th)17.1(e)-206(c)0(o)15.1(n)0(c)20.8(e)0(n)15.1(t)0(r)17.3(a)0(t)18.4(i)0(o)18.8(n)0(s)-196.2(o)0(f)-196.6(E)0(C)12.4(P)-204.8(an)20.8(d)-205.6(I)0(L)15.5(-)0(8)-196.6(w)0(e)16.9(r)0(e)-197(h)0(i)18.9(g)0(h)15.5(e)0(r)-197(i)0(n)-191.7(s)0(p)14.3(u)0(t)18.9(u)0(m)]TJ
0 -1.0527 TD
[(th)13.2(an)-218.2(in)-220.2(BA)18.3(L)-232.5(f)0(l)17.3(u)0(i)18.9(d)-228.4(in)-220.2(bo)21.2(th)-220.2(su)14.4(bj)18.8(ec)14.7(ts)-215.7(wi)14.9(th)-220.1(CO)18.3(PD)-220.9(an)15.1(d)-228.4(h)0(e)15.1(a)0(l)18.5(t)0(h)18.8(y)]TJ
T*
[(su)14.4(bj)18.9(ec)14.7(t)13.9(s)0(.)-571.4(S)11.4(pu)15.5(t)13.9(u)0(m)-568(a)0(n)15.1(d)-575.5(BA)18.3(L)-579.6(f)0(l)17.3(u)0(i)18.8(d)-575.5(E)12.2(C)0(P)-568.8(l)0(e)18.4(v)0(e)15.1(l)0(s)-568.5(d)0(i)18.9(d)-575.5(no)21.2(t)]TJ
0 -1.0471 TD
[(co)15.1(rr)18(el)18.4(at)12.8(e)-359.7(i)0(n)-356.7(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)-352.2(w)0(i)14.9(t)0(h)-351(C)0(O)12.6(P)11.4(D)-363.2(n)0(o)15.5(r)-360.9(in)-351(he)15.1(al)18.5(th)18.8(y)-365(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)17.7(.)]TJ
0 -1.0528 TD
[(Sp)16.3(ut)18.9(um)-346.1(an)15.1(d)-347.9(B)0(A)12.6(L)-352(fl)17.3(ui)18.9(d)-353.6(I)0(L)21.2(-)0(8)-344.6(l)0(e)18.4(v)0(e)15.1(l)0(s)-340.8(c)0(o)15.1(r)0(r)18(e)0(l)18.4(a)0(t)12.8(e)0(d)-337.7(i)0(n)-345.3(s)0(u)20(b)0(j)13.2(e)0(c)20.4(t)0(s)]TJ
0 -1.0471 TD
[(wi)14.9(th)-242.9(CO)12.6(P)11.4(D)-255.1(\()]TJ
/F7 1 Tf
5.1841 0 TD
(r)Tj
/F8 1 Tf
0.5463 0 TD
(=)Tj
/F3 1 Tf
0.5406 0 TD
[(0.)15.9(52)21.2(,)-250.8(p)]TJ
/F8 1 Tf
2.7087 0 TD
(=)Tj
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[(0.)15.9(02)21.2(6\))-247.8(bu)21.2(t)-253.5(n)0(o)15.5(t)-247.8(in)-248.6(he)20.8(al)18.5(th)13.2(y)-251.1(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)17.7(.)]TJ
/F4 1 Tf
-9.5203 -1.8039 TD
[(Spu)-8(tum)]TJ
/F3 1 Tf
3.6761 0 TD
(versus)Tj
/F4 1 Tf
3.2152 0 TD
[(biopsy)-685.7(samples)-8.7(.)]TJ
/F3 1 Tf
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[(T)12.2(h)0(e)-662(d)0(i)18.9(f)14.7(fe)19.2(re)19.2(nt)13.2(i)13.9(a)0(l)-664.4(c)0(e)20.4(l)0(l)]TJ
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0 -1.0471 TD
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0 -1.0471 TD
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0 -1.0527 TD
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0 -1.0471 TD
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0 -1.0528 TD
[(for)-352.6(most)-351.2(of)-350.2(the)-352.2(cells,)-352.4(whereas)-354.7(macr)-8.6(ophages)-7.3(,)-347.5(neutro)-9(phils)]TJ
T*
[(and)-708.3(lymphocyt)-9.5(es)-703.1(con)-8.4(tributed)-709.5(almost)-708.3(equall)-10.1(y)-700.7(t)0(o)-703.8(the)]TJ
0 -1.0471 TD
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0 -1.0528 TD
[(correl)-11(ations)-580(betw)-9.8(een)-577.8(sputum)-580.3(and)-577.4(biops)-7.4(y)-575.5(samp)-7.8(les)-575.3(for)]TJ
0 -1.0471 TD
[(macr)-8.6(ophages)-7.3(,)-671.9(n)0(e)-7.6(utrophil)-9.1(s,)-673.8(and)-674.2(lym)-7.8(phocyte)-8.5(s)-673.4(and)-674.2(be-)]TJ
0 -1.0528 TD
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0 -1.0471 TD
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0 -1.0527 TD
[(subje)-7.8(cts.)]TJ
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0 -2.4982 TD
[(Betw)-9(een-gr)26(oup)-338(analys)-8.6(is)]TJ
0 -1.6503 TD
[(Spu)-8(tum.)]TJ
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(mL)Tj
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(-1)Tj
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[(we)16.9(re)-333.6(si)17.7(g-)]TJ
-19.1202 -1.0527 TD
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ET
1 i 
58.28 373.72 478.205 -0.51 re
f
401.896 358.753 134.589 -0.283 re
f
58.28 342.312 478.205 -0.454 re
f
58.28 146.041 478.205 -0.454 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 387.553 Tm
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0 -1.0559 TD
[(disease)-336(\(COPD\))-333.1(and)-335.7(healthy)-327.4(controls)]TJ
/F3 1 Tf
44.3426 -1.7072 TD
(p-value)Tj
-30.742 -1.6693 TD
[(IS)-8224.7(BW)-7660(BAL)-4853.3(IS/BW)-2317.6(IS/BAL)-2153.8(BW/BAL)]TJ
/F6 1 Tf
-13.6006 -1.998 TD
(COPD)Tj
/F3 1 Tf
0 -1.0559 TD
[(Subjects)-335.1(n)-9351.1(1)0(8)-8465.4(1)0(0)-8459(1)0(6)]TJ
T*
[(Recovery)-336(mL)-5834.1(9.6)-330.7(\(2.7\26124.2\))-4859.7(8)-334.6(\(3\26114\))-5480.8(61)-334.1(\(15\26198\))]TJ
6.276 0 0 6.276 414.538 310.961 Tm
0.0001 Tc
(NS)Tj
8.966 0 0 8.966 454.847 310.961 Tm
0 Tc
[(0.0007)-2896.3(0.0005)]TJ
-44.2288 -1.0559 TD
[(TCC)-333.9(10)]TJ
6.725 0 0 5.977 87.591 305.461 Tm
(6)Tj
8.966 0 0 8.966 93.94 301.493 Tm
(cells)Tj
/F11 1 Tf
1.802 0.2213 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2213 TD
(mL)Tj
6.725 0 0 5.977 124.838 305.461 Tm
(-1)Tj
8.966 0 0 8.966 159.987 301.493 Tm
[(2.6)-330.7(\(0.4\26129.3\))-3481.3(0.07)-336.5(\(0.04\2613.8\))-3481.3(0.14)-330.2(\(0.01\2610.6\))-2488.6(0.0004)-2504.2(0.0001)-2896.3(0.0299)]TJ
-11.3433 -1.0559 TD
[(Squamous)-332.4(cells)-338.1(%)-5033(5)-328.3(\(0\26112\))-7308.2(0)-8959.1(0)]TJ
T*
[(Nonsq)-330.7(epith)-337.1(%*)-4773.2(0.1)-330.7(\(0\2612.8\))-4731.3(3.4)-337(\(0\26180.4\))-4730.8(0.3)-330.7(\(0\26117.9\))-3738.1(0.018)]TJ
6.276 0 0 6.276 461.707 282.557 Tm
0.0001 Tc
[(NS)-6796.3(NS)]TJ
8.966 0 0 8.966 58.28 273.09 Tm
0 Tc
[(Macrophages)-337.7(%*)-3843.8(19.4)-330.2(\(4.8\26163.7\))-2981.7(55.3)-336.5(\(2.2\26186.3\))-3481.3(85.8)-330.2(\(13.3\26194.2\))]TJ
6.276 0 0 6.276 414.538 273.09 Tm
0.0001 Tc
(NS)Tj
8.966 0 0 8.966 454.847 273.09 Tm
0 Tc
[(0.0007)-2896.3(0.0109)]TJ
-44.2288 -1.0559 TD
[(Neutrophils)-335.5(%*)-4514(77.3)-330.2(\(29.1\26194.2\))-2981.2(5.5)-337(\(0.2\26196.7\))-3980.8(1.7)-330.7(\(0.3\26185.5\))-2988.1(0.0173)-2504.2(0.0007)-2896.3(0.0251)]TJ
T*
[(L)53.9(ymphocytes)-335(%*)-4337(1.9)-330.7(\(0.7\2616\))-4731.3(3.5)-337(\(0.8\26118.9\))-3980.8(6.9)-330.7(\(1.2\26130.4\))]TJ
6.276 0 0 6.276 414.538 254.154 Tm
0.0001 Tc
(NS)Tj
8.966 0 0 8.966 454.847 254.154 Tm
0 Tc
(0.0007)Tj
6.276 0 0 6.276 512.334 254.154 Tm
0.0001 Tc
(NS)Tj
8.966 0 0 8.966 58.28 244.687 Tm
0 Tc
[(Eosinophils)-336.2(%*)-5000.9(1.2)-330.7(\(0\2618.5\))-4731.3(0.5)-337(\(0\2612.1\))-5230.8(0.4)-330.7(\(0\2611.7\))]TJ
6.276 0 0 6.276 414.538 244.687 Tm
0.0001 Tc
(NS)Tj
8.966 0 0 8.966 454.847 244.687 Tm
0 Tc
(0.0038)Tj
6.276 0 0 6.276 512.334 244.687 Tm
0.0001 Tc
(NS)Tj
/F6 1 Tf
8.966 0 0 8.966 58.28 235.219 Tm
0 Tc
(Controls)Tj
/F3 1 Tf
T*
[(Subjects)-335.1(n)-9370.1(1)32.1(1)-8478.5(1)0(0)-8471.7(1)32.1(1)]TJ
T*
[(Recovery)-336(mL)-5834.1(5.7)-330.7(\(3.9\26116.3\))-4606.7(10)-334.1(\(5\26118\))-5000.3(85)-334.1(\(36\2611)33.2(10\))]TJ
6.276 0 0 6.276 414.538 216.283 Tm
0.0001 Tc
(NS)Tj
8.966 0 0 8.966 454.847 216.283 Tm
0 Tc
[(0.0033)-2896.3(0.0033)]TJ
-44.2288 -1.0559 TD
[(TCC)-333.9(10)]TJ
6.725 0 0 5.977 87.591 210.841 Tm
(6)Tj
8.966 0 0 8.966 93.94 206.816 Tm
(cells)Tj
/F11 1 Tf
1.802 0.2276 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2276 TD
(mL)Tj
6.725 0 0 5.977 124.838 210.841 Tm
(-1)Tj
8.966 0 0 8.966 159.987 206.816 Tm
[(1.2)-330.7(\(0.8\2613.2\))-3981.3(0.06)-336.5(\(0.01\2610.13\))-2981.2(0.10)-330.2(\(0.03\2610.2\))-2488.6(0.0051)-2504.2(0.0033)-2896.3(0.0069)]TJ
-11.3433 -1.0496 TD
[(Squamous)-332.4(cells)-338.1(%)-5033(6)-328.3(\(3\26114\))-7308.2(0)-8959.1(0)]TJ
0 -1.0559 TD
[(Nonsq)-330.7(epith)-337.1(%*)-4773.2(1.8)-330.7(\(0.1\26118.8\))-2981.7(18.4)-336.5(\(1.0\26167.0\))-4979.8(0)-334.6(\(0\2614.6\))-3985.2(0.0069)]TJ
6.276 0 0 6.276 461.707 187.937 Tm
0.0001 Tc
(NS)Tj
8.966 0 0 8.966 505.474 187.937 Tm
0 Tc
(0.0051)Tj
-49.8751 -1.0559 TD
[(Macrophages)-337.7(%*)-3843.8(57.3)-330.2(\(34.2\26176.7\))-2481.7(72.0)-336.5(\(26.9\26196.5\))-2981.2(92.0)-330.2(\(70.4\26196.5\))]TJ
6.276 0 0 6.276 414.538 178.469 Tm
0.0001 Tc
(NS)Tj
8.966 0 0 8.966 454.847 178.469 Tm
0 Tc
[(0.0033)-2896.3(0.0125)]TJ
-44.2288 -1.0559 TD
[(Neutrophils)-335.5(%*)-4514(35.7)-330.2(\(17.6\26159.7\))-2981.2(3.4)-337(\(0\26125.2\))-4730.8(1.1)-330.7(\(0.1\2613.0\))-3488.1(0.0069)-2504.2(0.0033)-2896.3(0.0593)]TJ
T*
[(L)53.9(ymphocytes)-335(%*)-4337(3.5)-330.7(\(1\2617.2\))-4731.3(7.9)-337(\(0.9\26113.6\))-3980.8(7.1)-330.7(\(2.5\26126.5\))-2988.1(0.0284)-2504.2(0.0099)-2896.3(0.0745)]TJ
T*
[(Eosinophils)-336.2(%*)-5000.9(0.2)-330.7(\(0\2613.1\))-5983.2(0)-334.6(\(0\2610.3\))-4731.3(0.2)-330.7(\(0\2610.45\))-3738.1(0.03)]TJ
6.276 0 0 6.276 461.707 150.066 Tm
0.0001 Tc
[(NS)-6796.3(NS)]TJ
8.966 0 0 8.966 58.28 132.605 Tm
0 Tc
[(*:)-260.6(of)-265.5(total)-263.6(nonsquamous)-257.6(cells.)-265.1(Data)-262.4(are)-264.6(presented)-264.8(as)-259.2(median)-266.3(\(range\).)-261(IS:)-259.6(induced)-263.9(sputum;)-263.5(BW)28.6(:)-261.1(bronchial)-266.2(wash;)-257(BAL:)-264.8(bronchoalveolar)]TJ
T*
[(lavage;)-335.6(TCC:)-335.7(total)-333.2(cell)-337.4(count;)-336.6(Nonsq)-330.7(epith:)-339(nonsquamous)-333.5(epithelial)-334.9(cell.)]TJ
0 75.211 TD
-0.0321 Tc
[(11)-32.1(2)]TJ
7.472 0 0 7.472 260.164 797.499 Tm
0.0001 Tc
[(S.R.)-330.4(RUTG)-10.1(ERS)-332.6(ET)-263.8(AL.)]TJ
ET
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/F3 1 Tf
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/GS2 gs
0 Tc
[(pe)15.1(rc)19.2(en)15.1(t)13.9(a)0(g)15.1(e)0(s)-634.8(o)0(f)-634.8(n)0(e)20.8(u)0(t)18.9(r)0(o)13.9(p)0(h)21.2(i)0(l)16.5(s)-645(an)20.8(d)-643.8(e)0(o)15.1(s)0(i)17.7(n)0(o)21.2(p)0(h)15.5(i)0(l)16.5(s)-639.3(we)16.9(re)-635.2(si)17.7(g-)]TJ
0 -1.0527 TD
[(ni)18.9(fi)17.3(ca)14.7(nt)18.9(ly)-624.2(hi)18.9(gh)15.5(er)-623.8(\(p)]TJ
/F8 1 Tf
8.2513 0 TD
0 Tw
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(00)15.5(02)-621.8(an)15.1(d)-632.4(p)]TJ
/F8 1 Tf
5.8783 0 TD
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(01)15.5(,)-632(r)0(e)19.2(s)0(p)14.4(e)0(c)20.4(t)0(i)16.5(v)0(e)15.1(l)13.9(y\))]TJ
-15.2222 -1.0471 TD
[(an)15.1(d)-376.3(t)0(h)18.9(e)-382.4(pe)20.8(rc)13.5(en)20.8(ta)18.4(ge)15.1(s)-377.5(o)0(f)-373(e)0(p)20.8(i)0(t)16.5(h)0(e)15.1(l)0(i)16.5(a)0(l)-368.5(c)0(e)14.7(l)0(l)16.5(s)0(,)-366.5(m)0(a)17.7(c)0(r)13.5(o)0(p)21.2(h)0(a)15.1(g)0(e)20.8(s)-383.2(an)20.8(d)]TJ
0 -1.0527 TD
[(ly)18.9(mp)18.1(ho)15.5(cy)15.1(te)18.4(s)-616.5(w)0(e)16.9(r)0(e)-612.4(l)0(o)18.9(w)0(e)16.9(r)-616.9(\(p)]TJ
/F8 1 Tf
11.7453 0 TD
(=)Tj
/F3 1 Tf
0.5406 0 TD
[(0.)15.9(00)21.2(4,)-610(p)]TJ
/F8 1 Tf
3.5623 0 TD
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(00)15.5(01)-610.4(an)20.8(d)-621(p)]TJ
/F8 1 Tf
5.8499 0 TD
(=)Tj
/F3 1 Tf
-22.2444 -1.0471 TD
[(0.)15.9(02)21.2(,)-404.4(r)0(e)19.2(s)0(p)14.4(e)0(c)20.4(t)0(i)16.5(v)0(e)15.1(l)0(y)18.9(\))-406.4(i)13.9(n)-404.8(su)14.4(bj)18.9(ec)20.4(ts)-397.7(wi)14.9(th)-396.6(C)11.6(O)0(P)18.1(D)-408.7(th)18.9(an)-394.6(in)-396.6(he)20.8(al)12.8(-)]TJ
0 -1.0527 TD
[(th)18.9(y)-376.3(s)0(u)20(b)0(j)13.2(e)0(c)20.4(t)0(s)17.7(.)-376(Th)17.1(e)-376.7(p)0(e)20.8(r)0(c)13.5(e)0(n)20.8(t)0(a)18.4(g)0(e)15.1(s)-371.8(of)-367.3(ma)12(cr)19.2(op)21.2(ha)15.1(ge)15.1(s)-371.8(w)0(a)16.9(s)-377.5(si)17.7(mi)15.7(-)]TJ
0 -1.0471 TD
[(la)18.4(r)-355.2(i)0(n)-351(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)-346.5(w)0(i)14.9(t)0(h)-345.3(C)0(O)18.3(P)0(D)-351.8(a)0(n)20.8(d)-359.3(he)20.8(al)18.4(th)13.2(y)-353.6(s)0(u)20(b)0(j)13.2(e)0(c)20.4(t)0(s)17.7(.)-353.2(Sp)16.3(ut)18.9(um)]TJ
0 -1.0527 TD
[(EC)18.1(P)-563.3(a)0(n)15.1(d)-564.1(IL)21.2(-8)-555.1(co)15.1(nc)20.8(en)15.1(tr)17.3(at)18.5(io)18.9(ns)-554.7(we)16.9(re)-555.5(hi)18.9(gh)15.5(er)-555.5(in)-555.9(su)20(bj)18.9(ec)14.7(ts)]TJ
0 -1.0471 TD
[(wi)14.9(th)-425(CO)12.6(P)11.4(D)-437.2(th)18.9(an)-428.7(in)-430.7(he)20.8(al)12.8(th)18.9(y)-433.2(s)0(u)14.4(b)0(j)18.9(e)0(c)14.7(t)0(s)-426.2(\()0(p)]TJ
/F8 1 Tf
16.2124 0 TD
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(00)15.5(02)-428.3(an)20.8(d)-438.9(p)]TJ
/F8 1 Tf
5.4857 0 TD
(=)Tj
/F3 1 Tf
-22.2444 -1.0527 TD
[(0.)15.9(00)21.2(04)15.5(,)-319.1(r)0(e)13.5(s)0(p)20(e)0(c)14.7(t)0(i)16.5(v)0(e)20.8(l)0(y)18.9(\))0(.)]TJ
/F4 1 Tf
0 -2.6746 TD
[(Br)27.3(onchia)-7.4(l)-452.7(wash)-458.5(and)-457.5(br)31.4(onchoal)-8.1(veolar)-458.5(lavage)-463(fluid)-454.8(a)-6.5(n)0(d)]TJ
0 -1.0527 TD
[(biops)-7.4(y)-439.3(sam)-7.4(ples.)]TJ
/F3 1 Tf
6.9368 0 TD
[(Th)17.1(e)-433.7(p)0(e)20.8(r)0(c)13.5(e)0(n)20.8(t)0(a)18.4(g)0(e)15.1(s)-434.4(of)-424.2(eo)20.8(si)17.7(no)15.5(ph)21.2(il)16.5(s)-434.4(i)0(n)-425(B)11.6(W)]TJ
-6.9368 -1.0471 TD
[(an)15.1(d)-467.4(B)0(A)12.6(L)-471.5(fl)17.3(ui)18.9(d)-473.1(a)0(s)-464.1(w)0(e)16.9(l)0(l)-461.5(a)0(s)-464.1(t)0(h)18.8(e)-473.5(to)18.9(ta)18.4(l)-475.5(n)0(u)21.2(m)0(b)12.4(e)0(r)-464.5(o)0(f)-458.4(e)0(o)15.1(s)0(i)17.7(n)0(o)15.5(-)]TJ
0 -1.0527 TD
[(ph)15.5(il)22.2(s)-457.2(i)0(n)-447.8(B)0(W)-451.3(f)0(l)17.3(u)0(i)18.9(d)-456(we)16.9(re)-447.4(hi)18.9(gh)15.5(er)-447.4(in)-447.8(su)20(bj)18.9(ec)14.7(ts)-443.3(wi)14.9(th)-447.8(CO)18.3(PD)]TJ
0 -1.0471 TD
[(th)18.9(an)-479.9(in)-476.2(he)20.8(al)18.4(th)13.2(y)-484.5(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)-477.4(\()0(p)]TJ
/F8 1 Tf
11.1705 0 TD
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(00)15.5(5,)-473.5(p)]TJ
/F8 1 Tf
3.4257 0 TD
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(03)-479.5(an)20.8(d)-490.2(p)]TJ
/F8 1 Tf
4.6037 0 TD
(=)Tj
/F3 1 Tf
0.5406 0 TD
[(0.)15.9(01)21.2(,)]TJ
-20.8331 -1.0528 TD
[(re)19.2(sp)14.4(ec)20.4(ti)16.5(ve)15.1(ly)18.9(\).)-327.1(Th)17.1(e)-336.9(p)0(e)20.8(r)0(c)13.5(e)0(n)20.8(t)0(a)12.8(g)0(e)20.8(s)-337.7(of)-327.5(ma)17.7(cr)13.5(op)21.2(ha)15.1(ge)20.8(s)-337.7(w)0(a)16.9(s)-337.7(si)17.7(mi)15.7(-)]TJ
0 -1.0471 TD
[(la)18.4(r)-349.5(i)0(n)-345.3(B)11.6(W)-280.8(a)0(n)15.1(d)-347.9(BA)18.3(L)-352(f)0(l)17.3(u)0(i)18.9(d)-353.6(in)-339.7(su)14.4(bj)18.9(ec)20.4(ts)-346.5(w)12.4(i)0(t)16.5(h)-353.6(C)11.6(O)0(P)12.4(D)-351.8(an)20.8(d)-347.9(i)0(n)]TJ
0 -1.0528 TD
[(he)15.1(al)18.5(th)18.8(y)-336.5(s)0(u)14.4(b)0(j)18.9(e)0(c)14.7(t)0(s)17.7(.)-336.1(BW)-257.8(an)15.1(d)-336.5(B)0(A)12.6(L)-340.6(fl)17.3(ui)18.9(d)-336.5(E)0(C)12.4(P)-335.7(co)15.1(nc)20.8(en)15.1(tr)17.3(at)18.4(io)18.9(ns)]TJ
0 -1.0471 TD
[(we)16.9(re)-322.2(hi)13.2(gh)21.2(er)-322.2(in)-322.6(CO)12.6(P)11.4(D)-334.7(\(p)]TJ
/F8 1 Tf
9.8959 0 TD
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(01)-325.9(an)20.8(d)-336.5(p)]TJ
/F8 1 Tf
4.2964 0 TD
(=)Tj
/F3 1 Tf
0.5406 0 TD
[(0.)15.9(04)21.2(,)-330.4(r)0(e)13.5(s)0(p)20(e)0(c)14.7(t)0(i)16.5(v)0(e)20.8(l)0(y)18.9(\))0(.)]TJ
9.9186 20.5258 TD
[(Th)17.1(e)-376.7(n)0(u)15.5(m)0(b)18.1(e)0(r)19.2(s)-377.5(of)-367.3(CD)18.3(68)-365.7(an)15.1(d)-376.3(E)0(G)18.9(2)0(-)13.9(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)-366.1(c)0(e)14.7(l)0(l)16.5(s)-371.8(in)-368.1(bi)18.9(op)15.5(sy)]TJ
0 -1.0527 TD
[(sa)13.9(mp)18.1(le)18.4(s)-360.5(w)12.4(er)13.5(e)-354(h)0(i)13.2(g)0(h)21.2(e)0(r)-350.7(i)0(n)-351(C)11.6(OP)18.1(D)-363.2(\()0(p)]TJ
/F8 1 Tf
13.4923 0 TD
(=)Tj
/F3 1 Tf
0.5406 0 TD
[(0.)15.9(03)-348.7(an)20.8(d)-359.3(p)]TJ
/F8 1 Tf
4.3476 0 TD
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(04)15.5(9,)-348.3(re)19.2(-)]TJ
-18.9268 -1.0471 TD
[(sp)14.4(ec)20.4(ti)16.5(ve)15.1(ly)18.9(\),)-315.7(an)15.1(d)-325.1(t)0(h)18.9(e)-325.5(nu)15.5(mb)18.1(er)-316.5(of)-316.1(CD)12.6(3)-325.1(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)-314.9(c)0(e)14.7(l)0(l)16.5(s)-326.3(te)18.4(nd)15.5(ed)]TJ
0 -1.0527 TD
[(to)-316.9(be)-314.9(hi)18.9(gh)15.5(er)-316.5(in)-316.9(C)11.6(O)0(P)18.1(D)-329.1(\(p)]TJ
/F8 1 Tf
9.9926 0 TD
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(06)15.5(5\))19.6(.)]TJ
/F6 1 Tf
-1.3714 -3.5111 TD
[(Discu)-10.9(ssion)]TJ
/F3 1 Tf
-8.1659 -2.0998 TD
[(It)-278.6(w)12.4(a)0(s)-276.3(f)0(o)19.6(u)0(n)15.5(d)-279.6(th)18.9(at)-271.8(th)13.2(e)-280(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nt)18.9(ia)12.8(l)-282(c)0(o)20.8(u)0(n)15.5(t)-282(of)-270.6(in)18.8(fl)17.3(am)17.7(ma)12(to)18.9(ry)]TJ
-1.0015 -1.0471 TD
[(ce)14.7(ll)16.5(s)-303.6(i)0(n)-299.8(i)0(n)18.8(d)0(u)15.5(c)0(e)20.4(d)-308.1(sp)20(ut)18.9(um)-300.6(di)18.9(d)-308.1(n)0(o)21.2(t)-310.4(co)20.8(rr)18(el)12.8(at)18.5(e)-302.8(w)0(i)14.9(t)0(h)-299.8(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nt)18.9(ia)18.5(l)]TJ
0 -1.0528 TD
[(ce)14.7(ll)-222.5(co)15.1(un)21.2(ts)-227(in)-225.8(B)11.6(W)-161.3(an)15.1(d)-234.1(B)11.6(AL)-225.8(fl)17.3(ui)18.9(d)-234.1(n)0(o)15.5(r)-230(bi)18.9(op)15.5(sy)-224.6(sa)19.6(mp)18.1(le)12.8(s,)-224.3(bo)21.2(th)]TJ
0 -1.0471 TD
[(in)-248.6(su)14.4(bj)18.9(ec)20.4(ts)-249.8(wi)14.9(th)-248.6(C)11.6(O)0(P)12.4(D)-255.1(an)15.1(d)-256.8(h)0(e)20.8(a)0(l)18.5(t)0(h)13.2(y)-256.8(co)20.8(nt)18.8(ro)14(ls)17.7(.)-256.5(S)11.4(pu)15.5(tu)18.9(m)-260(E)12.2(CP)]TJ
0 -1.0528 TD
[(co)15.1(nc)15.1(en)20.8(tr)17.3(at)18.5(io)13.2(ns)-361.2(co)15.1(rr)18(el)18.5(at)18.4(ed)-366.1(wi)14.9(th)-368.1(B)11.6(W)-377.5(fl)17.3(ui)18.8(d)-376.3(E)0(C)18.1(P)-375.6(co)15.1(nc)20.8(en)15.1(tr)17.3(a-)]TJ
0 -1.0471 TD
[(ti)16.5(on)15.5(s)-223.9(a)0(n)20.8(d)-222.7(sp)14.4(ut)18.9(um)-215.2(IL)15.5(-8)-213.7(le)18.4(ve)15.1(ls)-215.7(co)20.8(rr)12.4(el)18.5(at)18.5(ed)-212.5(wi)14.9(th)-214.5(BA)12.6(L)-221.1(f)0(l)17.3(u)0(i)18.9(d)-228.4(IL)21.2(-)]TJ
0 -1.0527 TD
[(8)-279.6(l)13.9(ev)15.1(el)18.5(s)-275.1(i)0(n)-265.7(s)0(u)14.4(b)0(j)18.8(e)0(c)20.4(t)0(s)-266.9(w)0(i)14.9(t)0(h)-265.7(C)0(O)12.6(P)11.4(D.)-266.8(As)16.1(se)19.6(ss)18.9(in)13.2(g)-273.9(t)0(h)18.9(e)-274.3(di)18.9(f)14.7(f)0(e)19.2(r)0(e)19.2(n)0(c)15.1(e)0(s)]TJ
0 -1.0471 TD
[(be)15.1(tw)14.9(ee)20.4(n)-296.7(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)13.9(s)-297.9(w)12.4(it)16.5(h)-296.7(C)11.6(OP)12.4(D)-289.2(a)0(n)15.1(d)-291(he)15.1(al)18.4(th)18.9(y)-296.7(s)0(u)20(b)0(j)18.8(e)0(c)14.7(t)0(s)17.7(,)-290.6(hi)18.9(gh)15.5(er)]TJ
0 -1.0527 TD
[(pe)15.1(rc)19.2(en)15.1(ta)18.5(ge)15.1(s)-480(o)0(f)-475.4(s)0(p)20(u)0(t)18.9(u)0(m)-477(n)0(e)15.1(u)0(t)18.9(r)0(o)19.6(p)0(h)15.5(i)0(l)16.5(s)-480(an)15.1(d)-478.8(e)0(o)15.1(s)0(i)17.7(n)0(o)15.5(p)0(h)21.2(i)0(l)16.5(s)-480(an)15.1(d)]TJ
0 -1.0471 TD
[(hi)13.2(gh)21.2(er)-345(co)15.1(nc)20.8(en)15.1(tr)17.3(at)18.4(io)18.8(ns)-344.2(of)-344.6(sp)14.4(ut)18.9(um)-346.1(EC)18.1(P)-352.8(a)0(n)15.1(d)-353.6(IL)21.2(-8)-350.3(w)12.4(e)0(r)13.5(e)-354(ob)21.2(-)]TJ
0 -1.0528 TD
[(se)13.9(rv)19.6(ed)-508.4(in)-510.4(th)18.9(e)-513.3(C)0(O)12.6(P)11.4(D)-516.9(g)0(r)14(o)0(u)21.2(p)0(.)-507.6(T)0(h)17.1(e)-519(hi)18.8(gh)15.5(er)-504.3(pe)15.1(rc)19.2(en)15.1(ta)18.4(ge)-508.4(of)]TJ
0 -1.0471 TD
[(eo)15.1(si)17.7(no)15.5(ph)21.2(il)16.5(s)-275.1(a)0(n)20.8(d)-273.9(co)15.1(nc)20.8(en)15.1(tr)17.3(at)18.4(io)18.8(n)-273.9(o)0(f)-264.9(E)0(C)12.4(P)-273.1(in)-265.7(th)18.8(e)-274.3(C)11.6(OP)12.4(D)-272.2(g)0(r)19.6(o)0(u)15.5(p)]TJ
0 -1.0527 TD
[(wa)16.9(s)-252.3(a)0(l)18.5(s)0(o)-241.7(s)0(e)19.6(e)0(n)-246.6(i)13.9(n)-251.2(B)0(W)-172.4(a)0(n)20.8(d)-251.2(BA)18.3(L)-255.3(f)0(l)17.3(u)0(i)18.9(d)-251.2(.)-245.1(F)0(i)14(n)0(a)20.8(l)0(l)16.5(y)73.2(,)-250.8(h)0(i)18.8(g)0(h)15.5(e)0(r)-242.5(n)0(u)21.2(m)0(-)]TJ
0 -1.0471 TD
[(be)15.1(rs)-237.6(of)-236.4(ma)17.7(cr)13.5(op)21.2(ha)15.1(ge)20.8(s)-246.7(a)0(n)15.1(d)-239.8(ac)14.7(ti)16.5(va)20.8(te)12.8(d)-245.5(e)0(o)20.8(s)0(i)17.7(n)0(o)15.5(p)0(h)21.2(i)0(l)16.5(s)-246.7(we)16.9(re)-236.8(fo)19.6(un)15.5(d)]TJ
0 -1.0528 TD
[(in)-316.9(th)18.9(e)-325.5(b)0(i)18.8(o)0(p)15.5(s)0(y)-315.7(s)0(a)19.6(m)0(p)18.1(l)0(e)12.8(s)-320.6(of)-316.1(pa)15.1(ti)16.5(en)20.8(ts)-318.1(w)12.4(i)0(t)16.5(h)-325.1(CO)12.6(P)11.4(D)0(.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(e)-524.7(l)0(a)18.4(c)0(k)-508.4(o)0(f)-515.3(c)0(o)20.8(r)0(r)18(e)0(l)12.8(a)0(t)18.4(i)0(o)18.9(n)-518.6(be)15.1(tw)20.6(ee)14.7(n)-518.6(c)0(e)14.7(l)0(l)-507.1(d)0(i)13.2(f)20.4(fe)19.2(re)13.5(nt)18.8(ia)18.5(ls)-511.6(in)]TJ
-1.0015 -1.0528 TD
[(in)13.2(du)21.2(ce)14.7(d)-410.5(s)0(p)20(u)0(t)18.9(u)0(m)-403(a)0(n)20.8(d)-410.5(di)18.9(f)14.7(f)0(e)19.2(r)0(e)19.2(n)0(t)13.2(i)0(a)18.4(l)0(s)-397.7(i)0(n)-402.3(B)0(W)-331.8(a)0(n)20.8(d)-410.5(BA)12.6(L)-408.9(f)0(l)17.3(u)0(i)18.8(d)]TJ
0 -1.0471 TD
[(su)14.4(gg)21.2(es)14(ts)-301(th)18.8(at)-300.2(sp)14.4(ut)18.9(um)-300.6(is)-301(de)15.1(ri)17.3(ve)20.8(d)-313.7(f)0(r)18(o)0(m)-300.6(a)-314.2(di)18.9(f)20.4(f)0(e)19.2(r)0(e)13.5(n)0(t)-299.8(c)0(o)15.1(m)0(p)18.1(a)0(r)19.2(t)0(-)]TJ
0 -1.0528 TD
[(me)12(nt)-214.5(in)-214.5(th)18.8(e)-228.8(l)0(u)18.8(n)0(g)15.5(.)-222.3(T)12.2(h)0(e)-218.2(g)0(r)19.6(a)0(d)15.1(i)0(e)18.4(n)0(t)-214.5(o)0(f)-219.4(p)0(e)20.8(r)0(c)13.5(e)0(n)20.8(t)0(a)12.8(g)0(e)-212.5(o)0(f)-219.4(n)0(e)20.8(u)0(t)18.9(r)0(o)13.9(p)0(h)21.2(i)0(l)16.5(s)]TJ
0 -1.0471 TD
[(fr)12.4(om)-226.6(sp)14.4(ut)18.9(um)]TJ
/F4 1 Tf
5.2524 0 TD
[(vi)18.4(a)]TJ
/F3 1 Tf
1.4283 0 TD
[(BW)-229.4(fl)17.3(ui)13.2(d)-239.8(t)13.9(o)-239.8(B)0(A)12.6(L)-238.2(fl)17.3(ui)18.9(d)-239.8(a)0(n)15.1(d)-239.8(t)13.9(h)0(e)-235.2(r)0(e)19.2(c)0(i)18.4(p)0(r)14(o)0(c)20.8(a)0(l)]TJ
-6.6807 -1.0527 TD
[(gr)13.9(ad)20.8(ie)12.8(nt)-203.1(of)-202.3(pe)15.1(rc)19.2(en)15.1(ta)18.4(ge)-206.8(of)-202.3(ma)12(cr)19.2(op)15.5(ha)20.8(ge)15.1(s)-212.5(f)0(a)19.2(v)0(o)15.5(u)0(r)19.6(s)-218.2(a)-211.7(c)0(o)20.8(l)0(l)16.5(e)0(c)14.7(t)0(i)16.5(o)0(n)]TJ
0 -1.0471 TD
[(si)17.7(te)-448.2(pr)13.9(ox)21.2(im)15.7(al)-448.2(to)-447.8(th)13.2(at)-448.2(of)-447(th)18.9(e)-456.4(B)0(W)-451.3(f)0(l)17.3(u)0(i)18.9(d)0(,)]TJ
/F4 1 Tf
16.3774 0 TD
[(i.)13.5(e.)]TJ
/F3 1 Tf
1.6389 0 TD
[(in)-447.8(th)18.8(e)-456.4(l)0(a)18.5(r)14.7(ge)]TJ
-18.0163 -1.0528 TD
[(ai)12.8(rw)15.7(ay)20.8(s.)-508.8(Th)17.1(e)-519(d)0(i)18.9(f)20.4(fe)19.2(re)13.5(nc)20.8(es)-509.6(be)15.1(tw)14.9(ee)20.4(n)-518.6(i)0(n)18.8(d)0(u)15.5(c)0(e)20.4(d)-518.6(sp)20(ut)13.2(um)-505.4(an)15.1(d)]TJ
0 -1.0471 TD
[(la)12.8(va)20.8(ge)-371.8(fl)17.3(ui)18.9(ds)-366.9(ar)13.5(e)-376.8(m)0(o)18.1(s)0(t)-369.3(p)0(r)13.9(o)0(b)21.2(a)0(b)15.1(l)0(y)-368.1(n)0(o)21.2(t)-378.7(du)15.5(e)-376.7(t)0(o)-368.1(t)0(h)13.2(e)-376.7(te)18.4(ch)15.1(ni)18.8(ca)20.4(l)]TJ
0 -1.0527 TD
0.277 Tc
[(d)277(i)290.2(f)297.4(f)277(e)296.2(r)277(e)290.5(n)277(c)297.8(e)277(so)277(fi)277(n)290.2(h)277(a)297.8(l)277(a)295.4(t)277(i)293.5(o)277(no)277(fh)277(y)298.2(p)277(e)292.1(r)277(t)294.3(o)277(n)298.2(i)277(cs)277(a)291(l)277(i)293.5(n)277(ew)277(i)291.9(t)290.9(h)-8.3(s)277(p)291.3(u)277(t)295.9(u)277(m)]TJ
0 -1.0471 TD
0 Tc
[(in)13.2(du)21.2(ct)18.5(io)13.2(n)-211.3(a)0(n)15.1(d)-211.3(in)18.9(st)17.7(il)16.5(la)18.4(ti)16.5(on)-206.4(of)-208(no)21.2(rm)16.5(al)-209.2(sa)19.6(li)16.5(ne)-206.8(wi)20.6(th)-208.8(BA)18.3(L.)-204.4(It)-210.4(ha)20.8(s)]TJ
0 -1.0528 TD
[(be)15.1(en)-235.2(sh)14.4(ow)17.3(n)-239.8(p)0(r)14(e)0(v)20.8(i)0(o)13.2(u)0(s)20(l)0(y)-237.2(t)0(h)18.9(a)0(t)-237.6(i)0(n)18.9(d)0(u)15.5(c)0(e)20.4(d)-245.5(sp)20(ut)13.2(um)-238(do)21.2(es)-236.4(no)15.5(t)-242.1(h)0(a)15.1(v)0(e)]TJ
T*
[(a)-405.2(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(t)0(l)16.5(y)-399.1(di)18.9(f)14.7(f)0(e)19.2(r)0(e)19.2(n)0(t)-396.6(c)0(e)20.4(l)0(l)16.5(u)0(l)18.9(a)0(r)-396.2(c)0(o)20.8(m)0(p)18.1(o)0(s)14.3(i)0(t)16.5(i)0(o)18.9(n)-399.1(wh)17.3(en)-394.6(co)20.8(m-)]TJ
0 -1.0471 TD
[(pa)15.1(re)19.2(d)-262.5(w)0(i)14.9(t)0(h)-248.6(s)0(p)14.4(o)0(n)21.2(t)0(a)18.5(n)0(e)15.1(o)0(u)21.2(s)-263.7(sp)20(ut)13.2(um)-249.4(fr)18(om)-255.1(su)20(bj)18.9(ec)14.7(ts)-249.8(wi)14.9(th)-254.3(C)11.6(O)0(P)12.4(D)]TJ
0 -1.0527 TD
[([1)13.9(2].)-327.9(Moreo)-7.8(ver)29.9(,)-336.1(anothe)-7.8(r)-332.4(study)-343.1(showed)-340.2(that)-338.3(inhal)-9(ation)-339(of)]TJ
0 -1.0471 TD
[(hyp)-8(ertonic)-433.6(saline)-432.4(yielded)-432(more)-435(cells)-431.7(than)-426.9(inhal)-9(ation)-430.1(of)]TJ
0 -1.0527 TD
[(norm)-7.8(al)-357.1(saline,)-358.8(yet)-352.2(with)-358.9(a)-354(simila)-10.8(r)-349.5(differential)-360.4(count)-353.7([13].)]TJ
0 -1.0471 TD
[(The)-348.2(dif)10.8(ference)-10.1(s)-343.4(i)0(n)-345.3(cellular)-351.8(counts)-344.3(betwe)-10.9(en)-337.7(induce)-7.8(d)-342.2(spu-)]TJ
0 -1.0528 TD
[(tum)-366.3(and)-361.2(BW)-291.9(and)-361.2(BAL)-367.9(fluid,)-363.4(there)-8.6(fore,)-365.5(probabl)-9.7(y)-359.3(reflect)]TJ
0 -1.0471 TD
[(differences)-337(betw)-9.8(een)-333.2(compa)-7.8(rtments)-346.5(in)-334(the)-335.1(lung.)]TJ
1.0015 -1.0528 TD
[(Be)16.1(si)17.7(de)15.1(s)-241(s)0(a)13.9(m)0(p)18.1(l)0(i)16.5(n)0(g)-229.2(i)0(n)-237.2(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nt)-231.5(co)15.1(mp)18.1(ar)13.5(tm)21.4(en)15.1(ts)-232.7(in)-237.2(th)18.8(e)-240.2(l)0(u)18.9(n)0(g)15.5(,)]TJ
-1.0015 -1.0471 TD
[(th)13.2(e)-297.1(t)0(e)18.4(c)0(h)15.1(n)0(i)18.9(q)0(u)15.5(e)-297.1(of)-287.7(sa)13.9(mp)18.1(li)16.5(ng)-291.7(ma)17.7(y)-296.7(a)0(l)18.4(s)0(o)-292.9(c)0(o)15.1(n)0(t)18.9(r)0(i)17.3(b)0(u)21.2(t)0(e)-294.5(t)0(o)-288.4(t)0(h)18.9(e)-302.8(l)13.9(a)0(c)14.7(k)]TJ
0 -1.0528 TD
[(of)-481.1(co)15.1(rr)18(el)18.5(at)12.8(io)18.9(n)-490.2(o)0(f)-481.1(c)0(e)20.4(l)0(l)-484.3(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nt)18.9(ia)18.4(ls)-483.1(be)15.1(tw)20.6(ee)14.7(n)-490.2(s)0(p)20(u)0(t)13.2(u)0(m)-477(a)0(n)15.1(d)]TJ
0 -1.0471 TD
[(BA)12.6(L)-391.8(f)0(l)17.3(u)0(i)13.2(d)0(.)-382.4(S)11.4(pu)15.5(tu)18.9(m)-396.6(c)0(a)14.7(n)-393.4(be)-383.2(re)19.2(ga)15.1(rd)19.6(ed)-388.9(as)-384.4(a)-393.8(d)0(e)15.1(p)0(o)21.2(s)0(i)17.7(t)0(o)13.2(r)0(y)-384.4(f)0(o)19.6(r)]TJ
ET
1 i 
58.28 357.562 227.168 -0.51 re
f
58.28 341.121 227.168 -0.51 re
f
58.28 163.786 227.168 -0.51 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 371.395 Tm
[(Table)-331.9(4.)-336.7(\261)-940.2(Numbers)-607.2(of)-608.6(inflammatory)-605(cells)-610.6(in)-602.1(induced)]TJ
0 -1.0559 TD
[(sputum)-333.9(and)-329.3(bronchial)-340(biopsy)-331.6(samples)]TJ
/F3 1 Tf
13.3666 -1.7072 TD
[(COPD)-4073.5(Control)]TJ
/F6 1 Tf
-13.3666 -1.998 TD
[(Induced)-332.9(sputum)]TJ
/F3 1 Tf
0 -1.0559 TD
[(Subjects)-10843.8(18)-5929.9(1)25.8(1)]TJ
T*
[(Nonsq)-330.7(epith)]TJ
0.6639 -1.0559 TD
(10)Tj
6.725 0 0 5.977 73.191 304.271 Tm
(3)Tj
8.966 0 0 8.966 79.597 300.302 Tm
(cells)Tj
/F11 1 Tf
1.802 0.2213 TD
(.)Tj
/F3 1 Tf
0.2656 -0.2213 TD
(mL)Tj
6.725 0 0 5.977 110.494 304.271 Tm
(-1)Tj
8.966 0 0 8.966 178.186 309.77 Tm
[(0)-334.6(\(0\2612\))-3186.1(15)-334.1(\(3\261432\))]TJ
-13.373 -2.1118 TD
(Macrophages)Tj
0.6639 -1.0559 TD
(10)Tj
6.725 0 0 5.977 73.191 285.335 Tm
(3)Tj
8.966 0 0 8.966 79.597 281.367 Tm
(cells)Tj
/F11 1 Tf
1.802 0.2213 TD
(.)Tj
/F3 1 Tf
0.2656 -0.2213 TD
(mL)Tj
6.725 0 0 5.977 110.494 285.335 Tm
(-1)Tj
8.966 0 0 8.966 169.228 290.835 Tm
[(632)-333.6(\(4\261140\))-1187.1(646)-333.6(\(293\2611775\))]TJ
-12.3739 -2.1119 TD
(Neutrophils)Tj
0.6639 -1.0559 TD
(10)Tj
6.725 0 0 5.977 73.191 266.4 Tm
(3)Tj
8.966 0 0 8.966 79.597 262.431 Tm
(cells)Tj
/F11 1 Tf
1.802 0.2213 TD
(.)Tj
/F3 1 Tf
0.2656 -0.2213 TD
(mL)Tj
6.725 0 0 5.977 110.494 266.4 Tm
(-1)Tj
8.966 0 0 8.966 162.992 271.899 Tm
[(1945)-333.1(\(9\2612744\))]TJ
/F12 1 Tf
6.725 0 0 5.977 216.624 275.868 Tm
(1)Tj
/F3 1 Tf
8.966 0 0 8.966 224.504 271.899 Tm
[(432)-333.6(\(150\2611240\))]TJ
-18.5388 -2.1119 TD
[(L)53.9(ymphocytes)]TJ
0.6639 -1.0559 TD
(10)Tj
6.725 0 0 5.977 73.191 247.464 Tm
(3)Tj
8.966 0 0 8.966 79.597 243.496 Tm
(cells)Tj
/F11 1 Tf
1.802 0.2213 TD
(.)Tj
/F3 1 Tf
0.2656 -0.2213 TD
(mL)Tj
6.725 0 0 5.977 110.494 247.464 Tm
(-1)Tj
8.966 0 0 8.966 171.439 252.964 Tm
[(47)-334.1(\(8\261291\))-2439(43)-334.1(\(14\26191\))]TJ
-12.6205 -2.1118 TD
(Eosinophils)Tj
0.6639 -1.0559 TD
(10)Tj
6.725 0 0 5.977 73.191 228.529 Tm
(3)Tj
8.966 0 0 8.966 79.597 224.561 Tm
(cells)Tj
/F11 1 Tf
1.802 0.2213 TD
(.)Tj
/F3 1 Tf
0.2656 -0.2213 TD
(mL)Tj
6.725 0 0 5.977 110.494 228.529 Tm
(-1)Tj
8.966 0 0 8.966 169.795 234.028 Tm
[(26)-327.8(\(0\261593\))]TJ
/F13 1 Tf
6.725 0 0 5.977 209.934 237.997 Tm
({)Tj
/F3 1 Tf
8.966 0 0 8.966 237.94 234.028 Tm
[(2)-334.6(\(0\26150\))]TJ
/F6 1 Tf
-20.0373 -2.1119 TD
[(Biopsy)-332.6(samples)]TJ
/F3 1 Tf
0 -1.0559 TD
[(Subjects)-335.1(n)-10008.7(1)0(7)-5917.2(1)0(0)]TJ
T*
[(CD68+)-335.5(cells)]TJ
/F11 1 Tf
5.0836 0.2276 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2276 TD
(mm)Tj
6.725 0 0 5.977 120.076 200.183 Tm
(-2)Tj
8.966 0 0 8.966 158.683 196.157 Tm
[(1)25.8(155)-327.3(\(330\2612920\))]TJ
6.725 0 0 5.977 220.989 200.183 Tm
(#)Tj
8.966 0 0 8.966 224.504 196.157 Tm
[(590)-333.6(\(450\2611580\))]TJ
-18.5388 -1.0559 TD
[(Neut)-332.2(elastase)-337.3(cells)]TJ
/F11 1 Tf
7.4547 0.2276 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2276 TD
(mm)Tj
6.725 0 0 5.977 141.392 190.715 Tm
(-2)Tj
8.966 0 0 8.966 164.75 186.69 Tm
[(385)-333.6(\(10\2611250\))-1439(410)-333.6(\(0\261740\))]TJ
-11.8744 -1.0559 TD
[(CD3+)-336(cells)]TJ
/F11 1 Tf
4.5841 0.2276 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2276 TD
(mm)Tj
6.725 0 0 5.977 115.597 181.247 Tm
(-2)Tj
8.966 0 0 8.966 162.482 177.222 Tm
[(935)-333.6(\(170\2612240\))-439.4(385)-333.6(\(210\2611520\))]TJ
-11.6215 -1.0496 TD
[(EG2+)-334.8(cells)]TJ
/F11 1 Tf
4.5209 0.2213 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2213 TD
(mm)Tj
6.725 0 0 5.977 115.03 171.779 Tm
(-2)Tj
8.966 0 0 8.966 169.568 167.811 Tm
[(30)-334.1(\(0\261180\))]TJ
6.725 0 0 5.977 209.707 171.779 Tm
(+)Tj
8.966 0 0 8.966 235.729 167.811 Tm
[(10)-334.1(\(0\26140\))]TJ
-19.7907 -1.9475 TD
[(Data)-319.3(are)-315.1(presented)-315.4(as)-316.1(median)-316.9(\(range\).)-317.9(COPD:)-313.2(chronic)-315.5(obstruc-)]TJ
0 -1.0559 TD
[(tive)-407.2(pulmonary)-405.1(disease;)-413.4(Nonsq)-400.3(epith:)-408.5(nonsquamous)-409.4(epithelial)]TJ
T*
[(cell;)-573.2(EG2:)-576.2(secreted)-574.9(form)-577.2(of)-575.3(eosinophil)-572.1(cationic)-577.8(protein.)]TJ
6.725 0 0 5.977 279.213 135.383 Tm
(+)Tj
8.966 0 0 8.966 283.011 131.414 Tm
(:)Tj
-25.064 -1.0559 TD
(p)Tj
/F8 1 Tf
0.4995 0 TD
(=)Tj
/F3 1 Tf
0.5501 0 TD
(0.049;)Tj
6.725 0 0 5.977 92.976 125.915 Tm
(#)Tj
8.966 0 0 8.966 96.321 121.946 Tm
0.2991 Tc
(:p)Tj
/F8 1 Tf
1.0686 0 TD
0 Tc
(=)Tj
/F3 1 Tf
0.5501 0 TD
(0.03;)Tj
/F13 1 Tf
6.725 0 0 5.977 131.641 125.915 Tm
({)Tj
/F3 1 Tf
8.966 0 0 8.966 134.986 121.946 Tm
0.2991 Tc
(:p)Tj
/F8 1 Tf
1.0686 0 TD
0 Tc
(=)Tj
/F3 1 Tf
0.5564 0 TD
(0.01;)Tj
/F12 1 Tf
6.725 0 0 5.977 170.305 125.915 Tm
(1)Tj
/F3 1 Tf
8.966 0 0 8.966 173.764 121.946 Tm
0.2927 Tc
(:p)Tj
/F8 1 Tf
1.0686 0 TD
0 Tc
(=)Tj
/F3 1 Tf
0.5501 0 TD
[(0.0015,)-294.1(COPD)]TJ
/F4 1 Tf
6.247 0 TD
(versus)Tj
/F3 1 Tf
2.8263 0 TD
(con-)Tj
-23.5718 -1.0559 TD
(trol.)Tj
ET
58.28 758.834 478.205 -0.51 re
f
390.614 743.867 145.871 -0.284 re
f
58.28 727.427 478.205 -0.454 re
f
58.28 644.768 478.205 -0.51 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 772.667 Tm
[(Table)-331.9(3.)-336.7(\261)-655.7(Eosinophil)-320.1(cationic)-319.5(protein)-323.7(\(ECP\))-325.2(and)-316.7(interleukin-8)-328(\(IL-8\))-315.8(concentration)-326.7(in)-317.5(induced)-321.9(sputum)-321.3(\(IS\))-321.8(and)-323(bronchial)]TJ
T*
[(wash)-333.5(\(BW\))-332.3(and)-335.7(bronchoalveolar)-333.8(lavage)-336.5(\(BAL\))-333.1(fluid)]TJ
/F3 1 Tf
43.7166 -1.7072 TD
(p-value)Tj
-31.8106 -1.6693 TD
[(IS)-8654.6(BW)-7413.4(BAL)-5106.2(IS/BW)-2949.9(IS/BAL)-2779.8(BW/BAL)]TJ
/F6 1 Tf
-11.906 -1.998 TD
(COPD)Tj
/F3 1 Tf
0 -1.0559 TD
[(Subjects)-335.1(n)-7656.6(1)0(8)-8889(1)0(0)-8218.8(1)0(6)]TJ
T*
[(ECP)-334.1(pg)]TJ
/F11 1 Tf
3.1551 0.2213 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2213 TD
(mL)Tj
6.725 0 0 5.977 101.31 700.044 Tm
(-1)Tj
8.966 0 0 8.966 137.594 696.075 Tm
[(750)-333.6(\(1)31.7(15\26123760\))]TJ
/F12 1 Tf
6.725 0 0 5.977 199.899 700.044 Tm
(1)Tj
/F3 1 Tf
8.966 0 0 8.966 239.641 696.075 Tm
[(4)-328.3(\(0\261106\))]TJ
6.725 0 0 5.977 275.301 700.044 Tm
(#)Tj
8.966 0 0 8.966 324.283 696.075 Tm
[(0)-328.3(\(0\26162\))]TJ
6.725 0 0 5.977 355.464 700.044 Tm
(+)Tj
8.966 0 0 8.966 396.453 696.075 Tm
[(0.0007)-2965.8(0.0002)-3528.6(0.0069)]TJ
-37.7162 -1.0559 TD
[(IL-8)-332.2(ng)]TJ
/F11 1 Tf
3.0856 0.2213 TD
(.)Tj
/F3 1 Tf
0.2656 -0.2213 TD
(mL)Tj
6.725 0 0 5.977 100.687 690.576 Tm
(-1)Tj
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0 -1.0471 TD
[(ex)15.1(ac)20.4(er)19.2(ba)15.1(ti)16.5(on)21.2(s)-241(d)0(u)15.5(r)0(i)17.3(n)0(g)-229.2(t)0(h)18.9(e)-240.2(st)17.7(ud)21.2(y)73.2(,)-239.4(th)18.9(e)-240.2(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nc)15.1(es)-230.7(w)12.4(e)0(r)13.5(e)-234.5(du)15.5(e)-240.2(t)0(o)]TJ
0 -1.0527 TD
[(an)-223.9(on)15.5(go)21.2(in)18.9(g)-234.1(i)0(n)18.9(f)0(l)11.6(a)0(m)17.7(m)0(a)17.7(t)0(o)18.9(r)0(y)-225.1(p)0(r)14(o)0(c)20.8(e)0(s)19.6(s)-235.3(in)-225.8(th)18.9(e)-234.5(a)0(i)18.5(r)0(w)15.7(a)0(y)15.1(s)-229.6(in)-225.8(CO)18.3(PD)12.4(,)]TJ
0 -1.0471 TD
[(wh)17.3(ic)18.4(h)-393.4(p)0(e)20.8(r)0(s)12.8(i)0(s)17.7(t)0(s)-380.7(d)0(e)15.1(s)0(p)20(i)0(t)16.5(e)-393.8(sm)16.9(ok)21.2(in)18.9(g)-393.4(c)0(e)14.7(s)0(s)18.9(a)0(t)18.4(i)0(o)18.9(n)0(.)-382.4(T)0(h)17.1(e)-393.8(ma)17.7(in)-379.5(di)13.2(f-)]TJ
0 -1.0527 TD
[(fe)19.2(re)13.5(nc)20.8(e)-280(i)0(n)-271.4(a)0(i)18.5(r)0(w)15.7(a)0(y)-275.1(s)0(e)19.6(c)0(r)19.2(e)0(t)12.8(i)13.9(on)15.5(s)-280.8(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)-279.6(su)20(bj)18.9(ec)14.7(ts)-272.6(w)12.4(i)0(t)16.5(h)-279.6(CO)12.6(P)11.4(D)]TJ
0 -1.0471 TD
[(an)15.1(d)-296.7(h)0(e)20.8(a)0(l)12.8(t)0(h)18.9(y)-296.7(co)15.1(nt)18.9(ro)19.6(ls)-289.6(wa)16.9(s)-297.9(t)0(h)13.2(e)-297.1(hi)18.9(gh)15.5(er)-288.1(pe)15.1(rc)19.2(en)15.1(t)13.9(a)0(g)15.1(e)-297.1(of)-293.3(ne)20.8(ut)18.9(ro)13.9(-)]TJ
0 -1.0528 TD
[(ph)15.5(il)22.2(s)-252.3(i)0(n)-242.9(i)0(n)18.9(d)0(u)15.5(c)0(e)14.7(d)-251.2(sp)20(ut)18.9(um)18.1(.)-250.8(T)0(h)17.1(i)0(s)-244.1(d)0(i)18.9(f)14.7(fe)19.2(re)19.2(nc)15.1(e)-251.6(w)0(a)16.9(s)-252.3(no)21.2(t)-253.5(o)0(b)15.5(s)0(e)19.6(r)0(v)19.6(e)0(d)]TJ
0 -1.0471 TD
[(in)-237.2(BW)-172.4(an)20.8(d)-251.2(B)0(A)18.3(L)-249.6(fl)17.3(ui)18.9(d)-251.2(a)0(n)15.1(d)-245.5(bi)18.9(op)15.5(sy)-236(sa)13.9(mp)18.1(le)18.4(s)-252.3(a)0(n)20.8(d)-251.2(su)20(gg)15.5(es)19.6(ts)-238.4(an)]TJ
0 -1.0528 TD
[(ac)14.7(cu)20.8(mu)18.1(la)12.8(ti)22.2(on)-229.2(of)-219.4(ne)15.1(ut)18.9(ro)13.9(ph)21.2(il)16.5(s)-235.3(i)0(n)-220.2(t)0(h)13.2(e)-228.8(la)12.8(r)20.4(g)0(e)-223.9(a)0(i)18.5(r)0(w)15.7(a)0(y)15.1(s)-229.6(in)-225.8(CO)18.3(PD)12.4(.)]TJ
0 -1.0471 TD
[(Th)17.1(e)-280(l)13.9(ac)14.7(k)-279.6(o)0(f)-264.9(i)0(n)13.2(c)0(r)19.2(e)0(a)20.4(s)0(e)13.9(d)-273.9(nu)15.5(mb)18.1(er)13.5(s)-275.1(o)0(f)-270.6(n)0(e)20.8(u)0(t)13.2(r)0(o)19.6(p)0(h)21.2(i)0(l)16.5(s)-280.8(in)-265.7(br)13.9(on)21.2(ch)15.1(ia)18.4(l)]TJ
0 -1.0528 TD
[(bi)18.9(op)15.5(sy)-201.9(sa)13.9(mp)18.1(le)18.4(s)-212.5(i)0(n)-203.1(C)0(O)12.6(P)11.4(D)-215.2(m)0(a)17.7(y)-217(be)-201.1(du)15.5(e)-211.7(t)0(o)-203.1(r)0(a)19.2(p)0(i)13.2(d)-211.3(pu)15.5(l)13.9(s)0(e)13.9(d)-211.3(tr)17.3(an)15.1(s-)]TJ
T*
[(br)19.6(on)15.5(ch)15.1(i)13.9(a)0(l)-283.1(m)0(i)15.7(g)0(r)19.6(a)0(t)18.4(i)0(o)18.9(n)-291(of)-276.3(ne)15.1(ut)18.9(ro)13.9(ph)21.2(il)16.5(s,)-275.5(su)14.4(ch)-280.8(th)18.9(at)18.4(,)-284.9(a)0(t)-283.2(a)0(n)20.8(y)-291(ti)16.5(me)17.7(-)]TJ
0 -1.0471 TD
[(po)15.5(in)18.8(t,)-310.8(th)13.2(ei)18.4(r)-321(n)0(u)15.5(m)0(b)18.1(e)0(r)19.2(s)-326.3(in)-311.2(ti)16.5(ss)18.9(ue)15.1(s)-320.6(a)0(r)13.5(e)-319.8(lo)13.2(w)75(.)-324.7(Al)14.9(te)18.4(rn)19.6(at)18.5(iv)13.2(el)18.4(y)73.2(,)-324.7(th)18.9(is)]TJ
0 -1.0528 TD
[(ma)17.7(y)-450.3(b)0(e)-445.8(d)0(u)21.2(e)-450.7(to)-447.8(pr)19.6(ef)19.2(er)13.5(en)20.8(ti)16.5(al)-442.5(ac)14.7(cu)20.8(mu)12.4(l)13.9(a)0(t)12.8(i)0(o)18.9(n)-450.3(of)-441.3(ne)15.1(ut)18.9(ro)19.6(ph)15.5(il)16.5(s)]TJ
0 -1.0471 TD
[(wi)14.9(th)18.9(in)-254.3(th)18.9(e)-268.6(e)0(p)20.8(i)0(t)16.5(h)0(e)15.1(l)13.9(iu)13.2(m)-265.7(o)0(r)-253.5(i)0(n)-254.3(i)0(n)18.9(t)0(e)18.4(r)0(s)12.8(t)0(i)16.5(t)13.9(ia)12.8(l)-264.9(l)13.9(un)15.5(g)-262.5(t)0(i)16.5(s)0(s)18.9(u)0(e)15.1(,)-262.1(si)17.7(te)18.4(s)-263.7(n)0(o)15.5(t)]TJ
0 -1.0528 TD
[(in)18.9(ve)15.1(st)17.7(ig)18.9(at)18.5(ed)-314.9(in)-316.9(th)18.9(e)-325.5(p)0(r)19.6(e)0(s)13.9(e)0(n)20.8(t)-327.5(st)17.7(ud)21.2(y)67.5(.)]TJ
1.0015 -1.0471 TD
[(Re)16.1(la)18.4(ti)16.5(ve)15.1(ly)-214.5(lo)13.2(w)-226.6(p)0(e)20.8(r)0(c)13.5(e)0(n)20.8(t)0(a)12.8(g)0(e)20.8(s)-229.6(of)-219.4(eo)20.8(si)17.7(no)15.5(ph)21.2(il)16.5(s)-229.6(w)0(e)16.9(r)0(e)-219.8(f)0(o)19.6(u)0(n)15.5(d)-228.4(in)]TJ
-1.0015 -1.0527 TD
[(in)18.9(du)15.5(ce)20.4(d)-268.2(s)0(p)14.4(u)0(t)18.9(u)0(m)-260.7(a)0(n)20.8(d)-268.2(BW)-189.5(an)15.1(d)-268.2(B)11.6(AL)-260(fl)17.3(ui)13.2(d)-262.5(a)0(n)15.1(d)-268.2(lo)18.9(w)-272.2(n)0(u)21.2(m)0(b)18.1(e)0(r)13.5(s)]TJ
0 -1.0471 TD
[(of)-236.4(ac)20.4(ti)16.5(va)15.1(te)18.4(d)-245.5(e)0(o)20.8(s)0(i)17.7(n)0(o)15.5(p)0(h)21.2(i)0(l)16.5(s)-246.6(i)13.9(n)-245.5(bi)18.9(op)15.5(sy)-236(sa)19.6(mp)18.1(le)18.4(s)-246.7(i)0(n)-231.5(s)0(u)14.4(b)0(j)18.9(e)0(c)14.7(t)0(s)-232.7(w)0(i)14.9(t)0(h)]TJ
0 -1.0527 TD
[(CO)18.3(PD)12.4(,)-267.8(b)0(u)15.5(t)-270.6(th)18.8(es)13.9(e)-274.3(w)12.4(er)13.5(e)-268.6(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(t)0(l)16.5(y)-268.2(hi)13.2(gh)21.2(er)-265.3(th)18.9(an)-263.7(in)-265.7(he)20.8(al)18.4(th)13.2(y)]TJ
0 -1.0471 TD
[(co)15.1(nt)18.9(ro)19.6(ls)-255.5(in)-260(al)18.5(l)-264.9(c)0(o)20.8(m)0(p)12.4(a)0(r)19.2(t)0(m)15.7(e)0(n)15.1(t)13.9(s.)-258.4(Mo)19.3(re)13.5(ov)21.2(er)47.7(,)-267.8(h)0(i)18.9(g)0(h)21.2(e)0(r)-259.6(c)0(o)20.8(n)0(c)15.1(e)0(n)15.1(t)13.9(ra)13.5(-)]TJ
0 -1.0527 TD
[(ti)16.5(on)21.2(s)-280.8(o)0(f)-270.6(t)0(h)18.8(e)-280(ac)14.7(ti)16.5(va)20.8(ti)16.5(on)-269(ma)12(rk)19.6(er)-271(EC)18.1(P)-278.8(w)0(e)11.2(r)0(e)-271(f)0(o)19.6(u)0(n)15.5(d)-273.9(in)-271.4(in)13.2(du)21.2(ce)14.7(d)]TJ
0 -1.0471 TD
[(sp)20(ut)13.2(um)-255.1(in)-254.3(CO)18.3(PD)12.4(.)-262.2(I)0(t)-255.9(i)0(s)-255.5(n)0(o)15.5(t)-264.9(cl)18.4(ea)20.4(r)-264.1(w)0(h)11.6(e)0(t)18.4(h)0(e)20.8(r)-264.1(th)13.2(es)19.6(e)-262.9(e)0(o)15.1(s)0(i)17.7(n)0(o)21.2(p)0(h)15.5(i)0(l)16.5(s)]TJ
0 -1.0527 TD
[(ar)19.2(e)-325.5(a)0(b)15.1(l)0(e)-311.6(t)0(o)-316.9(c)0(a)14.7(u)0(s)20(e)-325.5(ti)16.5(ss)18.9(ue)-314.9(da)15.1(ma)17.7(ge)20.8(.)]TJ
1.0015 -1.0528 TD
[(Su)16.3(bj)18.9(ec)14.7(ts)-244.1(wi)14.9(th)-242.9(CO)12.6(P)11.4(D)-255.1(ha)15.1(d)-251.2(s)0(i)17.7(m)0(i)15.7(l)0(a)18.4(r)-258.4(pe)20.8(rc)13.5(en)20.8(ta)18.4(ge)15.1(s)-252.3(o)0(f)-247.8(s)0(p)20(u)0(t)13.2(u)0(m)]TJ
-1.0015 -1.0471 TD
[(an)15.1(d)-296.7(B)0(W)-223.7(a)0(n)20.8(d)-302.4(B)11.6(A)0(L)-294.1(f)0(l)17.3(u)0(i)18.9(d)-302.4(ma)17.7(cr)19.2(op)15.5(ha)20.8(ge)15.1(s)-297.9(b)0(u)15.5(t)-299.1(hi)18.9(gh)15.5(er)-293.7(nu)21.2(mb)18.1(er)13.5(s)]TJ
25.1977 66.1583 TD
[(of)-333.2(ai)18.4(rw)15.7(ay)-326.3(wa)16.9(ll)-330.6(ma)17.7(cr)13.5(op)21.2(ha)15.1(ge)15.1(s)-337.7(c)0(o)20.8(m)0(p)18.1(a)0(r)13.5(e)0(d)-326.3(w)0(i)14.9(t)0(h)-328.3(h)0(e)15.1(a)0(l)18.5(t)0(h)18.9(y)-336.5(co)15.1(n-)]TJ
0 -1.0471 TD
[(tr)17.3(ol)13.2(s.)-207.2(It)-210.4(is)-215.7(un)21.2(li)16.5(ke)15.1(ly)-208.8(th)18.8(at)-214.9(th)18.9(e)-223.1(d)0(i)18.9(f)20.4(fe)19.2(re)13.5(nt)-208.8(me)17.7(th)13.2(od)-206.4(of)-213.7(ma)17.7(cr)13.5(op)21.2(ha)15.1(ge)]TJ
0 -1.0528 TD
[(id)13.2(en)20.8(ti)16.5(fi)17.3(ca)14.7(ti)22.2(on)-468.2(in)-464.8(bi)18.9(op)15.5(sy)-463.7(sa)14(mp)18.1(le)18.4(s,)]TJ
/F4 1 Tf
13.7825 0 TD
[(i.)19.2(e.)]TJ
/F3 1 Tf
1.6559 0 TD
[(im)15.7(mu)18.1(no)15.5(cy)20.8(to)18.8(ch)15.1(em)17.7(-)]TJ
-15.4385 -1.0471 TD
[(is)17.7(tr)17.3(y)]TJ
/F4 1 Tf
2.1966 0 TD
[(ve)20.4(rs)18.8(us)]TJ
/F3 1 Tf
2.9648 0 TD
[(mo)18.1(rp)19.6(ho)15.5(lo)18.8(gy)-473.8(in)-470.5(sp)20(ut)18.8(um)-477(an)20.8(d)-478.8(B)0(W)-400.1(a)0(n)15.1(d)-478.8(BA)12.6(L)]TJ
-5.1613 -1.0528 TD
[(fl)17.3(ui)13.2(d,)-519(in)13.2(fl)17.3(ue)20.8(nc)15.1(ed)-525.5(th)18.9(e)-530.4(d)0(i)13.2(f)20.4(fe)19.2(re)13.5(nc)20.8(e)-536.1(i)0(n)-521.8(a)0(i)18.5(r)0(w)15.7(a)0(y)-525.5(w)0(a)16.9(l)0(l)-524.1(m)0(a)12(c)0(r)19.2(o)0(-)]TJ
0 -1.0471 TD
[(ph)15.5(ag)15.1(es)-230.8(be)15.1(tw)14.9(ee)20.4(n)-245.5(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)-232.7(w)0(i)14.9(t)0(h)-237.2(C)11.6(OP)12.4(D)-243.7(a)0(n)20.8(d)-245.5(he)15.1(al)18.4(th)18.8(y)-245.5(c)0(o)20.8(n)0(t)13.2(r)0(o)19.6(l)0(s)17.7(.)]TJ
1.0015 -1.0528 TD
[(Th)17.1(is)-318.1(st)17.7(ud)21.2(y)-325.1(e)0(x)15.1(p)0(l)18.9(o)0(r)19.6(e)0(d)-314.9(t)0(h)18.9(e)-325.5(ap)20.8(pl)13.2(ic)18.4(at)18.4(io)18.8(n)-325.1(o)0(f)-316.1(i)13.9(nd)15.5(uc)15.1(ed)-309.2(sp)14.3(ut)18.9(um)]TJ
-1.0015 -1.0471 TD
[(as)-321.8(an)-320.6(al)18.5(te)18.5(rn)13.9(at)18.5(iv)18.8(e)-331.2(t)0(o)-316.9(b)0(r)14(o)0(n)21.2(c)0(h)15.1(o)0(a)20.8(l)0(v)13.2(e)0(o)20.8(l)0(a)18.4(r)-332.4(la)18.4(va)15.1(ge)-314.9(an)15.1(d)-330.8(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(i)0(a)18.5(l)]TJ
0 -1.0527 TD
[(bi)13.2(op)21.2(si)17.7(es)-242.1(in)-242.9(re)19.2(se)19.6(ar)13.5(ch)-240.9(on)-240.5(ch)20.8(ro)13.9(ni)18.9(c)-251.6(o)0(b)21.2(s)0(t)17.7(r)0(u)13.9(c)0(t)18.5(i)0(v)18.8(e)-251.6(pu)21.2(lm)15.7(on)15.5(ar)19.2(y)-251.2(d)0(i)18.8(s)0(-)]TJ
T*
[(ea)14.7(se)19.6(.)-427.2(I)0(t)-415.2(w)0(a)16.9(s)-423.1(co)15.1(nc)20.8(lu)13.2(de)20.8(d)-421.9(t)0(h)13.2(a)0(t)-414(t)0(h)18.8(e)-428(di)18.9(f)20.4(f)0(e)19.2(r)0(e)13.5(n)0(t)18.9(i)0(a)18.4(l)-424.2(co)15.1(un)21.2(t)-424.2(o)0(f)-418.5(i)0(n)18.8(-)]TJ
0 -1.0471 TD
[(fl)17.3(am)12(ma)17.7(to)18.9(ry)-196.6(ce)14.7(l)13.9(l)0(s)-198.6(i)0(n)-197.4(i)0(n)18.9(d)0(u)21.2(c)0(e)14.7(d)-205.6(sp)20(ut)18.9(um)-198.2(do)15.5(es)-190.9(no)15.5(t)-202.3(c)0(o)15.1(r)0(r)18(e)0(l)18.5(a)0(t)12.8(e)-200.3(wi)14.9(th)]TJ
0 -1.0528 TD
[(fi)17.3(nd)15.5(in)18.9(gs)-475(in)-476.2(br)13.9(on)21.2(ch)15.1(ia)18.4(l)-481.2(w)0(a)11.2(s)0(h)-475(a)0(n)20.8(d)-484.5(br)14(on)21.2(ch)15.1(oa)20.8(lv)18.9(eo)15.1(la)18.5(r)-486.1(l)0(a)18.4(v)0(a)15.1(g)0(e)]TJ
0 -1.0471 TD
[(fl)17.3(ui)13.2(d)-336.5(o)0(r)-333.2(b)0(i)18.9(o)0(p)21.2(s)0(y)-332.8(s)0(a)19.6(m)0(p)18.1(l)0(e)12.8(s)-337.7(in)-328.3(su)20(bj)13.2(ec)20.4(ts)-329.5(wi)14.9(th)-328.3(ch)15.1(ro)19.6(ni)13.2(c)-336.9(o)0(b)15.5(s)0(t)17.7(r)0(u)19.6(c)0(-)]TJ
0 -1.0527 TD
[(ti)16.5(ve)-286.5(pu)21.2(lm)15.7(on)15.5(ar)19.2(y)-291(d)0(i)18.9(s)0(e)13.9(a)0(s)19.6(e)-291.4(an)15.1(d)-291(h)0(e)20.8(a)0(l)18.4(t)0(h)13.2(y)-291(co)20.8(nt)13.2(ro)19.6(ls)17.7(,)-290.6(w)0(h)17.3(e)0(r)19.2(e)0(a)14.7(s)-292.2(so)20(l-)]TJ
0 -1.0471 TD
[(ub)15.5(le)-539.2(ma)17.7(rk)19.6(er)13.5(s)-548.3(d)0(o)-536.4(c)0(o)20.8(r)0(r)18(e)0(l)12.8(a)0(t)18.5(e)0(.)-536.5(T)0(h)17.1(i)0(s)-540(s)0(u)20(g)0(g)15.5(e)0(s)19.6(t)0(s)-540(t)0(h)18.9(a)0(t)-539.2(i)0(n)18.9(d)0(u)21.2(c)0(e)14.7(d)]TJ
0 -1.0527 TD
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