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11.8553 0 0 9.8 253.32 637.33 Tm (C0)Tj 0 Tc 6.4001 0 0 6.4001 268.52 635.17 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0325 Tc 9.8 0 0 9.8 45.02 626.29 Tm (alveolar-end )Tj 0.0285 Tc 6.327 0 Td (tidal )Tj 0.0369 Tc 2.835 0 Td (gradients )Tj 0.05 Tc 10.0265 0 0 9.8 182.78 626.29 Tm (and )Tj 0.0422 Tc 9.8 0 0 9.8 207.83 626.29 Tm (haemodynamic )Tj 0.0421 Tc -16.601 -1.103 Td (parameters )Tj 0.0075 Tc 5.115 0 Td (were )Tj 0.0351 Tc 2.318 0 Td (determined )Tj 0.0228 Tc 5.168 0 Td (in )Tj 0.0279 Tc 1.182 0 Td (the )Tj 0.0269 Tc 1.629 0 Td (supine )Tj 0.0381 Tc 3.102 0 Td (position )Tj 0.05 Tc 10.1194 0 0 9.8 264.14 615.48 Tm (at )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.9867 0 0 9.8 44.8 604.45 Tm (TO, )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.8641 0 0 9.8 63.76 604.45 Tm (T6 )Tj 10.1832 0 0 9.8 80.3 604.45 Tm (and )Tj 10.9347 0 0 9.8 101.19 604.45 Tm (Tl2 )Tj 9.9356 0 0 9.8 122.38 604.45 Tm (months )Tj 0.0431 Tc 9.8 0 0 9.8 159.27 604.45 Tm (during )Tj 0.0279 Tc 3.362 0 Td (the )Tj 0.0265 Tc 1.824 0 Td (same )Tj 0.0444 Tc 2.657 0 Td (morning )Tj 0.0068 Tc -19.506 -1.127 Td (session. )Tj 0.05 Tc 9.9723 0 0 9.8 80.55 593.41 Tm (The )Tj 0.0229 Tc 9.8 0 0 9.8 100.9 593.41 Tm (sequence )Tj 0.0263 Tc 4.202 0 Td (used )Tj 0.0319 Tc 2.315 0 Td (for )Tj 0.0318 Tc 1.662 0 Td (supine )Tj 0.0331 Tc 3.171 0 Td (measurements )Tj 0.0211 Tc -17.093 -1.103 Td (was )Tj 0.0117 Tc 1.95 0 Td (as )Tj 0.0052 Tc 1.199 0 Td (follows: )Tj 0.0344 Tc 3.824 0 Td (I\) )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.3053 0 0 9.8 123.31 582.6 Tm (Ppa )Tj EMC ET BT /T1_0 1 Tf 0.0344 Tc 9.8 0 0 9.8 142.78 582.6 Tm (measurement; )Tj -0.035 Tc 9.5495 0 0 9.8 205.14 582.6 Tm (2\) )Tj 0.0351 Tc 9.8 0 0 9.8 216.34 582.6 Tm (simultaneous )Tj 0.0435 Tc -17.522 -1.127 Td (measurement )Tj 0.05 Tc 10.8509 0 0 9.8 106.94 571.56 Tm (of )Tj 0.0387 Tc 9.8 0 0 9.8 121.42 571.56 Tm (minute )Tj 0.0303 Tc 3.6 0 Td (ventilation, )Tj 0.0264 Tc 5.502 0 Td (expired )Tj 0.005 Tc 3.773 0 Td (gases, )Tj 0.0353 Tc -20.72 -1.101 Td (end )Tj 0.0224 Tc 2.359 0 Td (tidal )Tj 0.0148 Tc 2.737 0 Td (gas )Tj 0.0419 Tc 2.153 0 Td (composition )Tj 0.05 Tc 9.8699 0 0 9.8 176.06 560.77 Tm (and )Tj 0.0454 Tc 9.8 0 0 9.8 199.45 560.77 Tm (blood )Tj 0.0045 Tc 3.272 0 Td (gases; )Tj -0.035 Tc 9.7754 0 0 9.8 264.13 560.77 Tm (3\) )Tj 0.0262 Tc 9.8 0 0 9.8 44.78 549.73 Tm (Cerretelli's )Tj 0.0171 Tc 5.127 0 Td (modified )Tj 0.0398 Tc 4.287 0 Td (rebreathing )Tj 0.0323 Tc 5.436 0 Td (technique )Tj -0.035 Tc 9.2192 0 0 9.8 235.94 549.73 Tm ([5]. )Tj 0.0339 Tc 9.8 0 0 9.8 253.36 549.73 Tm (This )Tj 0.0318 Tc -21.312 -1.103 Td (supine )Tj 0.0299 Tc 3.233 0 Td (sequence )Tj 0.0211 Tc 4.348 0 Td (was )Tj 0.0347 Tc 2.106 0 Td (repeated )Tj -0.0011 Tc 4.162 0 Td (twice )Tj 0.0414 Tc 2.686 0 Td (after )Tj 0.0372 Tc 2.437 0 Td (pauses )Tj 0.0335 Tc 3.376 0 Td (to )Tj 0.0313 Tc -22.367 -1.127 Td (enable )Tj 0.0402 Tc 3.143 0 Td (the )Tj 0.0404 Tc 1.694 0 Td (patients )Tj 0.05 Tc 9.8951 0 0 9.8 128.62 527.88 Tm (to )Tj 9.8343 0 0 9.8 140.63 527.88 Tm (return )Tj 0.0335 Tc 9.8 0 0 9.8 170.38 527.88 Tm (to )Tj 0 Tc 1.216 0 Td (a )Tj 0.0383 Tc 0.829 0 Td (steady )Tj 0.0301 Tc 3.086 0 Td (state. )Tj 0.0477 Tc 2.656 0 Td (When )Tj -0.0017 Tc -20.65 -1.101 Td (in )Tj -0.0047 Tc 1.184 0 Td (use, )Tj 0.0353 Tc 1.999 0 Td (oxygen-therapy )Tj 0.05 Tc 10.2945 0 0 9.8 145.34 517.09 Tm (or )Tj 0.0339 Tc 9.8 0 0 9.8 157.9 517.09 Tm (ventilation )Tj 0.0229 Tc 5.012 0 Td (assistance )Tj 0.0075 Tc 4.613 0 Td (were )Tj 0.0418 Tc -21.233 -1.127 Td (withdrawn )Tj 0.05 Tc 10.4356 0 0 9.8 93.25 506.05 Tm (at )Tj 0.0302 Tc 9.8 0 0 9.8 104.8 506.05 Tm (least )Tj 0 Tc 2.329 0 Td [(2 )-88(h )]TJ 0.0254 Tc 1.77 0 Td (before )Tj 0.0319 Tc 3.058 0 Td (measurements. )Tj 0.0205 Tc -12.327 -1.103 Td (Clinical )Tj 0.0082 Tc 3.599 0 Td (follow )Tj 0.05 Tc 9.8342 0 0 9.8 118.56 495.24 Tm (up )Tj 0.0306 Tc 9.8 0 0 9.8 131.42 495.24 Tm (consisted )Tj 0.05 Tc 10.8509 0 0 9.8 172.94 495.24 Tm (of )Tj 0.0466 Tc 9.8 0 0 9.8 184.1 495.24 Tm (patient )Tj 0.0359 Tc 3.279 0 Td (history )Tj 0.0416 Tc 3.248 0 Td (along )Tj 0.0217 Tc -20.807 -1.126 Td (with )Tj 0.05 Tc 10.0277 0 0 9.8 64.9 484.21 Tm (standard )Tj 0.026 Tc 9.8 0 0 9.8 104.9 484.21 Tm (physical )Tj 0.0379 Tc 3.759 0 Td (examination. )Tj 0.0492 Tc 5.931 0 Td (Each )Tj 0.0466 Tc 2.433 0 Td (patient )Tj 0.0211 Tc 3.254 0 Td (was )Tj 0.0279 Tc -21.585 -1.103 Td (asked )Tj 0.044 Tc 2.801 0 Td (whether )Tj 0.016 Tc 3.869 0 Td (he )Tj 0.024 Tc 1.338 0 Td (experienced )Tj 0.0242 Tc 5.469 0 Td (tiredness, )Tj 0.0341 Tc 4.445 0 Td (shortness )Tj 0.05 Tc 10.5727 0 0 9.8 262.94 473.4 Tm (of )Tj 0.0378 Tc 9.8 0 0 9.8 44.17 462.37 Tm (breath, )Tj 0.0299 Tc 3.811 0 Td (inability )Tj 0.05 Tc 9.8951 0 0 9.8 124.54 462.37 Tm (to )Tj 0.043 Tc 9.8 0 0 9.8 140.87 462.37 Tm (work )Tj 0.05 Tc 10.0163 0 0 9.8 170.54 462.37 Tm (or )Tj 0.0076 Tc 9.8 0 0 9.8 187.3 462.37 Tm (sleep )Tj 0.0331 Tc 2.87 0 Td (disturbances. )Tj 0.0221 Tc -17.481 -1.127 Td (Breathlessness )Tj 0.0211 Tc 6.836 0 Td (was )Tj 0.0354 Tc 2.268 0 Td (evaluated )Tj 0.0398 Tc 4.799 0 Td (from )Tj 0 Tc 2.842 0 Td (1)Tj 0.341 0.341 0.329 rg 0.44 0 Td (-)Tj 0.165 0.169 0.157 rg 0.634 0 Td (5 )Tj 0.0219 Tc 1.116 0 Td (using )Tj 0.0279 Tc 2.937 0 Td (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0346 Tc 9.8 0 0 9.8 43.975 440.5258 Tm (Sadoul )Tj EMC ET BT /T1_0 1 Tf 0.0096 Tc 9.8 0 0 9.8 78.5788 440.5258 Tm (scale )Tj -0.0045 Tc 2.61 0 Td ([I]. )Tj 0.024 Tc 1.827 0 Td (Clinical )Tj 0.0068 Tc 3.89 0 Td (signs )Tj 0.05 Tc 10.8509 0 0 9.8 186.14 440.53 Tm (of )Tj 0.0365 Tc 9.8 0 0 9.8 199.91 440.53 Tm (right )Tj 0.0357 Tc 2.595 0 Td (ventricular )Tj 0.0196 Tc -18.523 -1.127 Td (failure )Tj 0.0157 Tc 3.463 0 Td (were )Tj 0.037 Tc 2.736 0 Td (looked )Tj 0.0114 Tc 3.646 0 Td (for. )Tj 0.0495 Tc 2.262 0 Td (Attention )Tj 0.0211 Tc 4.899 0 Td (was )Tj 0.0058 Tc 2.344 0 Td (given )Tj 0.0335 Tc 2.994 0 Td (to )Tj 0.0232 Tc -22.355 -1.103 Td (possible )Tj 0.019 Tc 4.024 0 Td (side )Tj 0.0047 Tc 2.233 0 Td (effects )Tj 0.0137 Tc 3.317 0 Td (by )Tj 0.0405 Tc 1.613 0 Td (measuring )Tj 0.0454 Tc 5.097 0 Td (blood )Tj 0.0281 Tc 3.087 0 Td (pressure, )Tj 0.05 Tc 9.8536 0 0 9.8 43.67 407.65 Tm (heart )Tj 0.0402 Tc 9.8 0 0 9.8 72.71 407.65 Tm (rate )Tj 0.05 Tc 10.0265 0 0 9.8 95.9 407.65 Tm (and )Tj 0.0137 Tc 9.8 0 0 9.8 119.29 407.65 Tm (by )Tj 0.0335 Tc 1.728 0 Td (checking )Tj 0.0319 Tc 4.554 0 Td (for )Tj 0.0324 Tc 2.018 0 Td (nausea, )Tj 0.0414 Tc 3.966 0 Td (tremor, )Tj 0.0355 Tc -20.004 -1.127 Td (peripheral )Tj 0.0445 Tc 4.751 0 Td (paraesthsia )Tj 0.05 Tc 10.0265 0 0 9.8 141.5 396.61 Tm (and )Tj 0.0424 Tc 9.8 0 0 9.8 160.71 396.61 Tm (disturbance )Tj 0.05 Tc 10.8509 0 0 9.8 213.74 396.61 Tm (of )Tj 0.0139 Tc 9.8 0 0 9.8 226 396.61 Tm (gait. )Tj 0.0142 Tc -17.58 -1.102 Td (Before )Tj 0.0402 Tc 3.161 0 Td (the )Tj 0.0411 Tc 1.658 0 Td (onset )Tj 0.05 Tc 10.8509 0 0 9.8 126.62 385.81 Tm (of )Tj 0.0439 Tc 9.8 0 0 9.8 138.94 385.81 Tm (therapy )Tj 0.0403 Tc 3.592 0 Td (conventional )Tj 0.0328 Tc 5.971 0 Td (spirogra\255)Tj 0.0337 Tc -19.331 -1.127 Td (phic )Tj 0.0375 Tc 2.2 0 Td (measurements )Tj 0.05 Tc 9.9256 0 0 9.8 128.76 374.77 Tm (\(Godart\) )Tj 0.0157 Tc 9.8 0 0 9.8 170.15 374.77 Tm (were )Tj 0.0411 Tc 2.379 0 Td (performed )Tj 0.0249 Tc 4.888 0 Td (includ\255)Tj 0.0186 Tc -20.204 -1.103 Td (ing )Tj 0.0109 Tc 1.72 0 Td (vital )Tj 0.035 Tc 2.269 0 Td (capacity )Tj 0.0104 Tc 4.014 0 Td (\(VC\), )Tj 0.0245 Tc 2.793 0 Td (forced )Tj 0.0412 Tc 3.111 0 Td (expiratory )Tj 0.0335 Tc 4.906 0 Td (volume )Tj -0.0017 Tc 3.569 0 Td (in )Tj 0.0356 Tc -22.409 -1.126 Td (one )Tj 0.028 Tc 1.905 0 Td (second )Tj 0.05 Tc 9.8976 0 0 9.8 94.2 352.93 Tm (\(FEV)Tj 0 Tc 6.2 0 0 6.2 118.35 350.77 Tm (1)Tj 0.608 0.348 Td (\) )Tj 0.05 Tc 10.0265 0 0 9.8 128.78 352.93 Tm (and )Tj 0.0276 Tc 9.8 0 0 9.8 148.07 352.93 Tm (residual )Tj 0.0335 Tc 3.746 0 Td (volume )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0318 Tc 9.8 0 0 9.8 219.2376 352.93 Tm (\(RV\) )Tj EMC ET BT /T1_0 1 Tf 0.0382 Tc 9.8 0 0 9.8 244.0904 352.93 Tm (by )Tj 0.0402 Tc 1.393 0 Td (the )Tj 0.0239 Tc -21.893 -1.128 Td (helium )Tj 0.0366 Tc 3.567 0 Td (dilution )Tj 0.0432 Tc 4.048 0 Td (method. )Tj 0.05 Tc 9.954 0 0 9.8 159.03 341.88 Tm (Total )Tj 0.0413 Tc 9.8 0 0 9.8 188.56 341.88 Tm (lung )Tj 0.035 Tc 2.52 0 Td (capacity )Tj 0.0211 Tc 4.246 0 Td (was )Tj 0.0343 Tc -21.634 -1.101 Td (calculated )Tj 0.0117 Tc 4.849 0 Td (as )Tj 0.0402 Tc 1.355 0 Td (the )Tj 0.0368 Tc 1.8 0 Td (sum )Tj 0.05 Tc 10.8509 0 0 9.8 143.42 331.09 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.8926 0 0 9.8 156.46 331.09 Tm (VC )Tj EMC ET BT /T1_0 1 Tf 10.0265 0 0 9.8 175.58 331.09 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0148 Tc 9.8 0 0 9.8 196.27 331.09 Tm (RV. )Tj EMC ET BT /T1_0 1 Tf 0.0245 Tc 9.8 0 0 9.8 217.8986 331.09 Tm (Values )Tj 0.0157 Tc 3.381 0 Td (were )Tj 0.0181 Tc -21.242 -1.127 Td (expressed )Tj 0.0117 Tc 4.433 0 Td (as )Tj 0 Tc 1.176 0 Td (a )Tj 0.0347 Tc 0.771 0 Td (percentage )Tj 0.05 Tc 10.8509 0 0 9.8 153.98 320.05 Tm (of )Tj 0.0325 Tc 9.8 0 0 9.8 165.38 320.05 Tm (predicted )Tj -0.035 Tc 9.6519 0 0 9.8 207.85 320.05 Tm ([21]. )Tj 0.0375 Tc 9.8 0 0 9.8 228.68 320.05 Tm (Blood )Tj 0.0148 Tc 2.886 0 Td (gas )Tj -21.839 -1.127 Td (values )Tj 0.0157 Tc 2.915 0 Td (were )Tj 0.038 Tc 2.277 0 Td (measured )Tj 0.049 Tc 4.426 0 Td (on )Tj 0.0271 Tc 1.366 0 Td (samples )Tj 0.05 Tc 9.8178 0 0 9.8 186.39 309.01 Tm (drawn )Tj 0.0342 Tc 9.8 0 0 9.8 215.9 309.01 Tm (either )Tj 0.048 Tc 2.693 0 Td (from )Tj 0 Tc 2.401 0 Td (a )Tj -0.0046 Tc -22.777 -1.102 Td (flexible )Tj 0.0484 Tc 3.43 0 Td (catheter )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.3798 0 0 9.8 114.13 298.21 Tm (\(TO, )Tj EMC ET BT /T1_0 1 Tf 0.0262 Tc 9.8 0 0 9.8 135.28 298.21 Tm (T6, )Tj 0.05 Tc 10.488 0 0 9.8 153.27 298.21 Tm (Tl2\) )Tj 10.2945 0 0 9.8 177.02 298.21 Tm (or )Tj 0.0398 Tc 9.8 0 0 9.8 189.73 298.21 Tm (from )Tj 0 Tc 2.499 0 Td (a )Tj 0.0231 Tc 0.842 0 Td (needle )Tj 0.05 Tc 10.4928 0 0 9.8 253.08 298.21 Tm (\(Tl, )Tj 0.0139 Tc 9.8 0 0 9.8 42.64 287.17 Tm (T2, )Tj 0.0262 Tc 1.984 0 Td [(T4, )-292(T8, )]TJ ET BT /Suspect <>BDC /T1_0 1 Tf 0.0089 Tc 9.8 0 0 9.8 101.2048 287.17 Tm (TIO\) )Tj EMC ET BT /T1_0 1 Tf 0.0264 Tc 9.8 0 0 9.8 126.6456 287.17 Tm (inserted )Tj 0.0366 Tc 3.978 0 Td (percutaneously )Tj 0.0425 Tc 7.092 0 Td (into )Tj 0.0279 Tc 2.308 0 Td (the )Tj 0.0387 Tc -21.964 -1.128 Td (brachial )Tj 0.0332 Tc 4.323 0 Td (artery. )Tj 0.0401 Tc 3.657 0 Td (Arterial )Tj 0.0393 Tc 4.264 0 Td (blood )Tj 0.0089 Tc 3.28 0 Td (was )Tj 0.0266 Tc 2.417 0 Td (immediately )Tj 0.0306 Tc -17.953 -1.101 Td (analysed )Tj 0.0319 Tc 4.309 0 Td (for )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.1538 0 0 9.8 102.43 265.33 Tm (Pao)Tj 0 Tc 6.2 0 0 6.2 119.49 263.17 Tm (2)Tj 0.648 0.348 Td (, )Tj EMC /Suspect <>BDC 0.05 Tc 10.4014 0 0 9.8 131.23 265.33 Tm (Paco)Tj 0 Tc 6.2 0 0 6.2 153.81 263.17 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.0265 0 0 9.8 162.86 265.33 Tm (and )Tj 10.4514 0 0 9.8 184.1 265.33 Tm (pH )Tj 10.4356 0 0 9.8 202.93 265.33 Tm (at )Tj -0.0325 Tc 9.8 0 0 9.8 216.61 265.33 Tm (37 )Tj 0.255 0.255 0.243 rg -0.035 Tc 11.8973 0 0 14.7 231.72 265.33 Tm (oc )Tj 0.165 0.169 0.157 rg 0.0158 Tc 9.8 0 0 9.8 248.16 265.33 Tm (using )Tj 0.05 Tc 9.8612 0 0 9.8 42.38 254.28 Tm (appropriate )Tj 0.0259 Tc 9.8 0 0 9.8 95.42 254.28 Tm (electrodes )Tj 0.0434 Tc 4.627 0 Td (\(Corning )Tj 0.0083 Tc 4.364 0 Td (I68\), )Tj 0.0387 Tc 2.323 0 Td (arterial )Tj 0.0179 Tc 3.454 0 Td (oxygen )Tj 0.05 Tc 9.8448 0 0 9.8 42.34 243.25 Tm (saturation )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0405 Tc 9.8 0 0 9.8 90.6 243.25 Tm (\(Sao)Tj 0 Tc 6.2 0 0 6.2 110.37 241.33 Tm (2)Tj 0.618 0.31 Td (\) )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.0265 0 0 9.8 122.54 243.25 Tm (and )Tj 0.0482 Tc 9.8 0 0 9.8 143.3 243.25 Tm (plasma )Tj 0.0469 Tc 3.599 0 Td (bicarbonate )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.9764 0 0 9.8 234.12 243.25 Tm (\(HCO )Tj EMC /Suspect <>BDC 0.0121 Tc 9.8 0 0 9.8 261.73 243.25 Tm (3\) )Tj EMC ET BT /T1_0 1 Tf 0.0075 Tc 9.8 0 0 9.8 42.2296 232.4504 Tm (were )Tj 0.255 0.255 0.243 rg 0.0279 Tc 2.342 0 Td (calculated. )Tj 0.165 0.169 0.157 rg 0.05 Tc 9.829 0 0 9.8 52.28 221.41 Tm (Minute )Tj 0.0339 Tc 9.8 0 0 9.8 88.54 221.41 Tm (ventilation )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0121 Tc 9.8 0 0 9.8 139.5588 221.41 Tm (\(VE\), )Tj EMC ET BT /T1_0 1 Tf 0.0224 Tc 9.8 0 0 9.8 168.214 221.41 Tm (tidal )Tj 0.0335 Tc 2.449 0 Td (volume )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0097 Tc 9.8 0 0 9.8 228.5918 221.41 Tm (\(VT\) )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.8699 0 0 9.8 254.3 221.41 Tm (and )Tj 0.0399 Tc 9.8 0 0 9.8 42.23 210.61 Tm (respiratory )Tj 0.0278 Tc 5.402 0 Td (frequency )Tj /T1_1 1 Tf 0.0282 Tc 9.4 0 0 9.4 143.59 210.61 Tm (\(f\) )Tj /T1_0 1 Tf 0.0157 Tc 9.8 0 0 9.8 159.83 210.61 Tm (were )Tj 0.0378 Tc 2.661 0 Td (determined )Tj 0.0299 Tc 5.518 0 Td (with )Tj 0 Tc 2.562 0 Td (a )Tj 0.02 Tc -22.745 -1.128 Td (Fleisch )Tj 0.05 Tc 9.9234 0 0 9.8 78.28 199.56 Tm (No. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9.8 0 0 9.8 100.74 199.56 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.8572 0 0 9.8 111.86 199.56 Tm (pneumotachograph )Tj 0.0321 Tc 9.8 0 0 9.8 201.26 199.56 Tm (connected )Tj 0.05 Tc 9.8951 0 0 9.8 250.3 199.56 Tm (to )Tj 0 Tc 9.8 0 0 9.8 265.1 199.56 Tm (a )Tj 0.0236 Tc -22.767 -1.101 Td (Validyne )Tj 0.0468 Tc 4.408 0 Td (transducer )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.3473 0 0 9.8 135.55 188.77 Tm (MP )Tj EMC ET BT /T1_0 1 Tf -0.0296 Tc 9.8 0 0 9.8 156.2 188.77 Tm (45 )Tj 0.05 Tc 12.147 0 0 9.8 171.22 188.77 Tm (\(\2612 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.9706 0 0 9.8 194.54 188.77 Tm (cmH)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 215.71 186.37 Tm (2)Tj /T1_0 1 Tf 0.05 Tc 11.702 0 0 9.8 219.96 188.77 Tm (0\) )Tj EMC ET BT /T1_0 1 Tf 0.0299 Tc 9.8 0 0 9.8 235.67 188.77 Tm (with )Tj 0.0476 Tc 2.44 0 Td (an )Tj 0.0274 Tc -22.212 -1.127 Td (electronic )Tj 0.0389 Tc 4.533 0 Td (integrator. )Tj 0.0494 Tc -3.499 -1.127 Td (Haemodynamic )Tj 0.0448 Tc 7.354 0 Td (parameters )Tj 0.0157 Tc 5.287 0 Td (were )Tj 0.0205 Tc 2.464 0 Td (collected )Tj 0.0217 Tc 4.27 0 Td (with )Tj 0 Tc 2.342 0 Td (a )Tj 0.05 Tc 9.9254 0 0 9.8 41.66 155.88 Tm (Grandjean )Tj 0.0222 Tc 9.8 0 0 9.8 95.41 155.88 Tm (floating )Tj 0.0484 Tc 4.14 0 Td (catheter )Tj -0.035 Tc 8.8252 0 0 9.8 178.59 155.88 Tm ([9] )Tj 0.0287 Tc 9.8 0 0 9.8 196.92 155.88 Tm (\(flexo-pulmocath )Tj -0.035 Tc 9.5393 0 0 9.8 42.39 144.85 Tm (125 )Tj /T1_2 1 Tf 0 Tc 10.8 0 0 10.8 58.92 144.85 Tm (x )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0161 Tc 9.8 0 0 9.8 66.38 144.85 Tm (O.I\) )Tj EMC ET BT /T1_0 1 Tf 0.0292 Tc 9.8 0 0 9.8 84.9804 144.85 Tm (placed )Tj 0.0207 Tc 3.027 0 Td (inside )Tj 0.0279 Tc 2.798 0 Td (the )Tj 0.05 Tc 9.8115 0 0 9.8 157.46 144.85 Tm (pulmonary )Tj 0.0332 Tc 9.8 0 0 9.8 206.78 144.85 Tm (artery. )Tj 0.0473 Tc 3.11 0 Td (Correct )Tj 0.0362 Tc -19.971 -1.102 Td (placement )Tj 0.0211 Tc 4.723 0 Td (was )Tj 0.0294 Tc 1.95 0 Td (checked )Tj 0.05 Tc 9.9193 0 0 9.8 144.25 134.05 Tm (by )Tj 0.0357 Tc 9.8 0 0 9.8 157.91 134.05 Tm (recording )Tj 0.0294 Tc 4.485 0 Td (pressure )Tj 0.0127 Tc 3.882 0 Td (curves. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.026 Tc 9.8 0 0 9.8 41.486 123.0054 Tm (Pressures )Tj EMC ET BT /T1_0 1 Tf 0.0075 Tc 9.8 0 0 9.8 85.6742 123.0054 Tm (were )Tj 0.0415 Tc 2.497 0 Td (measured )Tj 0.0381 Tc 4.63 0 Td (with )Tj 0 Tc 2.391 0 Td (a )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.9705 0 0 9.8 188.7 123.01 Tm (Statham )Tj EMC /Suspect <>BDC 0 Tc 9.8 0 0 9.8 229.4 123.01 Tm (P )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.386 0 0 9.8 240.18 123.01 Tm (23 )Tj 0.049 Tc 9.8 0 0 9.8 254.83 123.01 Tm (DB )Tj 0.0432 Tc -21.801 -1.103 Td (electromanometer )Tj 0.0382 Tc 8.302 0 Td (connected )Tj 0.0401 Tc 4.882 0 Td (together )Tj 0.0299 Tc 4.017 0 Td (with )Tj 0.0279 Tc 2.374 0 Td (the )Tj -0.0084 Tc 1.755 0 Td (elec\255)Tj 0.0488 Tc -21.298 -1.127 Td (trocardiograph )Tj 0.05 Tc 9.8951 0 0 9.8 110.38 101.16 Tm (to )Tj 0 Tc 9.8 0 0 9.8 123.74 101.16 Tm (a )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0209 Tc 9.8 0 0 9.8 133.1578 101.16 Tm (Phillips )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.9991 0 0 9.8 169.86 101.16 Tm (EM )Tj 10.2667 0 0 9.8 191.69 101.16 Tm (II )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9.8 0 0 9.8 200.54 101.16 Tm (0 )Tj EMC ET BT /T1_0 1 Tf 0.0273 Tc 9.8 0 0 9.8 210.2322 101.16 Tm (recorder. )Tj 0.05 Tc 9.8256 0 0 9.8 252.88 101.16 Tm (The )Tj 0.0195 Tc 9.8 0 0 9.8 41.27 90.37 Tm (reference )Tj 0.0183 Tc 4.404 0 Td (zero )Tj 0.0329 Tc 2.309 0 Td (pressure )Tj -0.0098 Tc 4.08 0 Td (level )Tj 0.0211 Tc 2.432 0 Td (was )Tj 0.0421 Tc 2.142 0 Td (standardized )Tj 0.05 Tc 9.8951 0 0 9.8 251.02 90.37 Tm (to )Tj 0 Tc 9.8 0 0 9.8 264.62 90.37 Tm (a )Tj -0.016 Tc 3.305 66.905 Td (fixed )Tj 0.0478 Tc 2.679 0 Td (mean )Tj 0.0225 Tc 2.963 0 Td (mid-chest )Tj 0.0307 Tc 4.744 0 Td (distance )Tj 0.0433 Tc 4.114 0 Td (determined )Tj 0.048 Tc 5.533 0 Td (from )Tj 0 Tc 2.768 0 Td (a )Tj 0.0319 Tc -22.804 -1.102 Td (sample )Tj 0.05 Tc 10.5727 0 0 9.8 329.9 735.24 Tm (of )Tj -0.0194 Tc 9.8 0 0 9.8 341.86 735.24 Tm (six )Tj 0.0369 Tc 1.51 0 Td (patients )Tj 0.05 Tc 10.0265 0 0 9.8 393.26 735.24 Tm (and )Tj 0.0181 Tc 9.8 0 0 9.8 412.8 735.24 Tm (used )Tj 0.05 Tc 10.0233 0 0 9.8 435.02 735.24 Tm (on )Tj 0.0418 Tc 9.8 0 0 9.8 448.94 735.24 Tm (each )Tj 0.0367 Tc 2.335 0 Td (test )Tj 0.05 Tc 10.0131 0 0 9.8 489.99 735.24 Tm (day )Tj 10.1832 0 0 9.8 509.18 735.24 Tm (and )Tj 0.0319 Tc 9.8 0 0 9.8 297.01 724.45 Tm (for )Tj -0.0154 Tc 1.887 0 Td (all )Tj 0.0404 Tc 1.629 0 Td (patients )Tj 0.05 Tc 9.9284 0 0 9.8 371.02 724.45 Tm (throughout )Tj 0.0402 Tc 9.8 0 0 9.8 425.02 724.45 Tm (the )Tj 0.0403 Tc 1.922 0 Td (study )Tj 0.0473 Tc 2.945 0 Td (in )Tj 0.05 Tc 10.0673 0 0 9.8 487.1 724.45 Tm (order )Tj 10.1862 0 0 9.8 516.46 724.45 Tm (to )Tj 0.0465 Tc 9.8 0 0 9.8 296.78 713.41 Tm (compare )Tj 0.0285 Tc 4.092 0 Td (identical )Tj -0.0072 Tc 4.016 0 Td (levels )Tj 0.05 Tc 10.5727 0 0 9.8 402.38 713.41 Tm (of )Tj 0.0294 Tc 9.8 0 0 9.8 414.26 713.41 Tm (pressure )Tj 0.0464 Tc 3.89 0 Td (measurements )Tj 0.0473 Tc 6.582 0 Td (in )Tj -0.0154 Tc -22.435 -1.103 Td (all )Tj 0.0316 Tc 1.335 0 Td (patients. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.81 0 0 9.8 349.16 702.6 Tm (Pulmonary )Tj EMC ET BT /T1_0 1 Tf 0.0409 Tc 9.8 0 0 9.8 399.02 702.6 Tm (artery )Tj 0.0329 Tc 2.853 0 Td (pressure )Tj 0.0334 Tc 3.866 0 Td (was )Tj 0.05 Tc 9.8334 0 0 9.8 483.82 702.6 Tm (measured )Tj 0.0303 Tc 9.8 0 0 9.8 296.89 691.8 Tm (before )Tj 0.0337 Tc 3.074 0 Td (each )Tj 0.025 Tc 2.327 0 Td (assessment )Tj 0.05 Tc 10.5727 0 0 9.8 399.5 691.8 Tm (of )Tj 0.0414 Tc 9.8 0 0 9.8 411.5 691.8 Tm (cardiac )Tj 0.05 Tc 10.1739 0 0 9.8 445.82 691.8 Tm (output )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.011 Tc 9.8 0 0 9.8 478.2 691.8 Tm (\(Qc\). )Tj EMC ET BT /T1_0 1 Tf 0.0492 Tc 9.8 0 0 9.8 503.6996 691.8 Tm (Each )Tj 0.0329 Tc -21.127 -1.126 Td (pressure )Tj 0.03 Tc 3.841 0 Td (value )Tj 0.0211 Tc 2.548 0 Td (was )Tj 0.0289 Tc 1.877 0 Td (averaged )Tj 0.0441 Tc 4.113 0 Td (for )Tj -0.0343 Tc 1.543 0 Td (five )Tj 0.0448 Tc 1.773 0 Td (respiratory )Tj 0.0046 Tc 5.06 0 Td (cycles )Tj 0.05 Tc 9.8699 0 0 9.8 296.78 669.97 Tm (and )Tj 0.0402 Tc 9.8 0 0 9.8 317.5 669.97 Tm (the )Tj 0.0397 Tc 1.812 0 Td (mean )Tj 0.05 Tc 10.5727 0 0 9.8 363.26 669.97 Tm (of )Tj 0.0281 Tc 9.8 0 0 9.8 376.78 669.97 Tm (three )Tj 0.0051 Tc 2.633 0 Td (successive )Tj 0.0246 Tc 4.763 0 Td (values )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.8206 0 0 9.8 480.6 669.97 Tm (\(Ppa\) )Tj EMC ET BT /T1_0 1 Tf 0.0211 Tc 9.8 0 0 9.8 509.03 669.97 Tm (was )Tj 0.029 Tc -21.649 -1.128 Td (retained. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0325 Tc 9.8 0 0 9.8 338.0592 658.9156 Tm (Qc )Tj EMC ET BT /T1_0 1 Tf 0.0211 Tc 9.8 0 0 9.8 353.994 658.9156 Tm (was )Tj 0.0228 Tc 2.05 0 Td (indirectly )Tj 0.0378 Tc 4.456 0 Td (determined )Tj 0.0478 Tc 5.289 0 Td (according )Tj 0.05 Tc 9.8951 0 0 9.8 516.22 658.92 Tm (to )Tj 0.0438 Tc 9.8 0 0 9.8 296.84 648.12 Tm (Fick's )Tj 0.0288 Tc 3.141 0 Td (principle )Tj 0.05 Tc 10.0265 0 0 9.8 370.22 648.12 Tm (and )Tj 0.0279 Tc 9.8 0 0 9.8 391.9 648.12 Tm (the )Tj 0.0423 Tc 1.862 0 Td (rebreathing )Tj 0.0414 Tc 5.558 0 Td (technique )Tj -0.035 Tc 9.4074 0 0 9.8 511.69 648.12 Tm ([5]. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0368 Tc 9.8 0 0 9.8 296.6 637.33 Tm (Patients )Tj EMC ET BT /T1_0 1 Tf 0.0075 Tc 9.8 0 0 9.8 332.8698 637.33 Tm (were )Tj 0.0352 Tc 2.244 0 Td (connected )Tj 0.0335 Tc 4.637 0 Td (to )Tj 0 Tc 1.118 0 Td (a )Tj 0.0435 Tc 0.764 0 Td (Douglas )Tj 0.05 Tc 9.8605 0 0 9.8 456.73 637.33 Tm (bag )Tj 10.1832 0 0 9.8 474.62 637.33 Tm (and )Tj 0.0346 Tc 9.8 0 0 9.8 493.1 637.33 Tm (expired )Tj 0.0076 Tc -20.055 -1.127 Td (gases )Tj 0.0075 Tc 2.677 0 Td (were )Tj 0.0147 Tc 2.44 0 Td (collected; )Tj 0.0332 Tc 4.506 0 Td (end-tidal )Tj 0.0387 Tc 4.31 0 Td (arterial )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9.8 0 0 9.8 468.1492 626.2854 Tm (0)Tj 6.4001 0 0 6.4001 476.36 624.12 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.1832 0 0 9.8 484.94 626.29 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 12.0563 0 0 9.8 505.31 626.29 Tm (C0)Tj 0 Tc 6.4001 0 0 6.4001 520.76 623.88 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0294 Tc 9.8 0 0 9.8 296.42 615.48 Tm (pressure )Tj 0.0103 Tc 4.226 0 Td (differences )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.2452 0 0 9.8 388.99 615.48 Tm (P\(ET-a\)0)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 431.47 613.09 Tm (2)Tj 0.642 0.385 Td (, )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.2168 0 0 9.8 444.67 615.48 Tm (P\(a-ET\)C0)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 494.35 613.09 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0239 Tc 9.8 0 0 9.8 504.71 615.48 Tm (were )Tj 0.0321 Tc -21.27 -1.126 Td (simultaneously )Tj 0.0326 Tc 6.845 0 Td (measured. )Tj 0.0421 Tc -5.808 -1.102 Td (End-tidal )Tj 0.0137 Tc 4.455 0 Td (gases )Tj 0.0157 Tc 2.603 0 Td (were )Tj 0.038 Tc 2.374 0 Td (measured )Tj 0.0137 Tc 4.509 0 Td (by )Tj 0 Tc 1.434 0 Td (a )Tj 0.0457 Tc 0.841 0 Td (mass )Tj 0.0372 Tc 2.535 0 Td (spectro\255)Tj 0.0451 Tc -19.8 -1.128 Td (meter )Tj 0.0384 Tc 2.833 0 Td (calibrated )Tj 0.0319 Tc 4.701 0 Td (for )Tj 0.0337 Tc 1.642 0 Td (each )Tj 0.0336 Tc 2.327 0 Td (experiment )Tj 0.028 Tc 5.202 0 Td (using )Tj 0.0402 Tc 2.692 0 Td (the )Tj 0.0346 Tc 1.727 0 Td (same )Tj 0.0271 Tc -21.129 -1.127 Td (gas )Tj 0.038 Tc 1.99 0 Td (mixture )Tj 0.0117 Tc 3.959 0 Td (as )Tj 0.0402 Tc 1.478 0 Td (the )Tj 0.05 Tc 9.8242 0 0 9.8 387.61 571.56 Tm (blood )Tj 0.0271 Tc 9.8 0 0 9.8 417.76 571.56 Tm (gas )Tj 0.0369 Tc 2.006 0 Td (analyser )Tj 0.0444 Tc 4.186 0 Td (\(Centronic )Tj 0.05 Tc 10.3037 0 0 9.8 296.35 560.77 Tm (MGA )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0006 Tc 9.8 0 0 9.8 325.38 560.77 Tm (200\) )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.0265 0 0 9.8 347.18 560.77 Tm (and )Tj 0.036 Tc 9.8 0 0 9.8 366.47 560.77 Tm (recorded )Tj 0.0137 Tc 4.165 0 Td (by )Tj 0.05 Tc 9.9257 0 0 9.8 421.1 560.77 Tm (Gould )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0224 Tc 9.8 0 0 9.8 451.86 560.77 Tm (ES )Tj EMC /Suspect <>BDC -0.0061 Tc 1.661 0 Td (1000 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.9393 0 0 9.8 491.18 560.77 Tm (appara\255)Tj 0.0096 Tc 9.8 0 0 9.8 296.38 549.73 Tm (tus; )Tj 0.0454 Tc 1.938 0 Td (blood )Tj 0.023 Tc 2.923 0 Td (samples )Tj 0.0075 Tc 3.785 0 Td (were )Tj 0.0321 Tc 2.411 0 Td (simultaneously )Tj 0.05 Tc 9.9071 0 0 9.8 472.23 549.73 Tm (drawn )Tj 0.048 Tc 9.8 0 0 9.8 503.41 549.73 Tm (from )Tj 0.0279 Tc -21.15 -1.103 Td (the )Tj 0.0387 Tc 1.706 0 Td (arterial )Tj 0.0018 Tc 3.529 0 Td (line. )Tj 0.05 Tc 10.3529 0 0 9.8 369.1 538.92 Tm (At )Tj 0.0279 Tc 9.8 0 0 9.8 383.98 538.92 Tm (the )Tj 0.0353 Tc 1.682 0 Td (end )Tj 0.05 Tc 10.8509 0 0 9.8 419.66 538.92 Tm (of )Tj 0.0279 Tc 9.8 0 0 9.8 432.22 538.92 Tm (the )Tj 0.0301 Tc 1.682 0 Td (collection )Tj 0.0364 Tc 4.641 0 Td (period, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 11.8553 0 0 9.8 295.8 527.88 Tm (C0)Tj 0 Tc 6.8001 0 0 6.8001 311.24 525.48 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.8596 0 0 9.8 317.3 527.88 Tm (production )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0388 Tc 9.8 0 0 9.8 367.08 527.88 Tm (\(\\TC0)Tj 0 Tc 6.8001 0 0 6.8001 392.84 525.73 Tm (2)Tj 0.565 0.316 Td (\) )Tj EMC ET BT /T1_0 1 Tf 0.0211 Tc 9.8 0 0 9.8 402.47 527.88 Tm (was )Tj 0.0304 Tc 1.828 0 Td (calculated. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0438 Tc 9.8 0 0 9.8 468.6886 527.88 Tm (Patients )Tj EMC ET BT /T1_0 1 Tf 0.0479 Tc 9.8 0 0 9.8 505.664 527.88 Tm (then )Tj 0.0405 Tc -21.379 -1.101 Td (rebreathed )Tj 0 Tc 4.889 0 Td (a )Tj 0.0323 Tc 0.744 0 Td (hypoxic-hypercapnic )Tj 0.0271 Tc 9.274 0 Td (gas )Tj 0.05 Tc 9.8907 0 0 9.8 458.52 517.09 Tm (\(7% )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 12.0563 0 0 9.8 479.39 517.09 Tm (C0)Tj 0 Tc 6.3001 0 0 6.3001 495.08 514.68 Tm (2)Tj 0.638 0.383 Td (, )Tj EMC ET BT /T1_0 1 Tf 0.0376 Tc 9.8 0 0 9.8 504.86 517.09 Tm (12% )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9.8 0 0 9.8 295.8162 506.0454 Tm (0)Tj 0.812 -0.221 Td (2)Tj 0.432 0.221 Td (, )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.6766 0 0 9.8 314.93 506.05 Tm (8I% )Tj 0 Tc 9.8 0 0 9.8 339.16 506.05 Tm (N)Tj 6.2 0 0 6.2 347.73 503.88 Tm (2)Tj 0.618 0.35 Td (\) )Tj 0.0316 Tc 9.8 0 0 9.8 359.41 506.05 Tm (from )Tj 0 Tc 2.572 0 Td (a )Tj 0.0169 Tc 0.935 0 Td (2-litre )Tj 0.05 Tc 9.8605 0 0 9.8 423.37 506.05 Tm (bag )Tj 0.0383 Tc 9.8 0 0 9.8 443.04 506.05 Tm (until )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 12.0563 0 0 9.8 467.15 506.05 Tm (C0)Tj 0 Tc 6.2 0 0 6.2 482.37 503.88 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0377 Tc 9.8 0 0 9.8 491.03 506.05 Tm (reached )Tj 0.0379 Tc -19.944 -1.103 Td (equilibrium )Tj 0.0265 Tc 5.423 0 Td (between )Tj 0.0266 Tc 3.894 0 Td (bag, )Tj 0.0143 Tc 2.193 0 Td (alveoli )Tj 0.05 Tc 10.0265 0 0 9.8 439.82 495.24 Tm (and )Tj 0.0245 Tc 9.8 0 0 9.8 459.02 495.24 Tm (capillaries; )Tj 0.0259 Tc 5.078 0 Td (this )Tj 0.0211 Tc -21.746 -1.126 Td (was )Tj 0.05 Tc 9.8048 0 0 9.8 315.75 484.21 Tm (obtained )Tj 0.0308 Tc 9.8 0 0 9.8 357.35 484.21 Tm (when )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 11.8553 0 0 9.8 383.88 484.21 Tm (C0)Tj 0 Tc 6.2 0 0 6.2 398.85 482.28 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0294 Tc 9.8 0 0 9.8 407.06 484.21 Tm (pressure )Tj 0.0336 Tc 4.013 0 Td (reached )Tj 0 Tc 3.762 0 Td (a )Tj 0.05 Tc 9.9055 0 0 9.8 492.5 484.21 Tm (plateau )Tj ET BT /Suspect <>BDC /T1_3 1 Tf -0.0347 Tc 9.2 0 0 9.2 295.78 473.17 Tm (\(P )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 6.5905 0 0 6.2 305.05 473.17 Tm (pla)Tj 0 Tc 6.2 0 0 6.2 314.19 471.01 Tm (1)Tj 0.05 Tc 11.8553 0 0 9.8 316.68 473.17 Tm (C0)Tj 0 Tc 9.8 0 0 9.8 331.86 471.01 Tm (2)Tj -0.0008 Tc 0.392 0.22 Td (\), )Tj 0.0252 Tc 0.961 0 Td (usually )Tj 0.0291 Tc 3.379 0 Td (within )Tj -0.035 Tc 9.1317 0 0 9.8 409.36 473.17 Tm (15 )Tj 0.341 0.341 0.329 rg 9.1232 0 0 9.8 421.55 473.17 Tm (s. )Tj ET BT /Suspect <>BDC 0.165 0.169 0.157 rg /T1_0 1 Tf 0 Tc 9.8 0 0 9.8 431.72 473.17 Tm (P )Tj EMC /Suspect <>BDC 0.255 0.255 0.243 rg 6.2 0 0 6.2 437.53 473.17 Tm (p)Tj -0.035 Tc 4.8344 0 0 6.2 441.2 471.24 Tm (10)Tj 0.05 Tc 11.8626 0 0 9.8 446.45 473.17 Tm (,0)Tj 0 Tc 6.2 0 0 6.2 457.17 471.24 Tm (2 )Tj EMC ET BT 0.165 0.169 0.157 rg /T1_0 1 Tf -0.034 Tc 9.8 0 0 9.8 464.39 473.17 Tm (wa )Tj 0.031 Tc 1.958 0 Td (measured )Tj 0.05 Tc 10.4356 0 0 9.8 295.57 462.37 Tm (at )Tj 0.0346 Tc 9.8 0 0 9.8 306.82 462.37 Tm (same )Tj 0.0135 Tc 2.535 0 Td (time )Tj 0.0362 Tc 2.171 0 Td (as )Tj ET BT /Suspect <>BDC /T1_4 1 Tf 0 Tc 9.4 0 0 9.4 364.73 462.37 Tm (P )Tj EMC /Suspect <>BDC /T1_0 1 Tf 9.8 0 0 9.8 370.76 462.37 Tm (P)Tj 6.4001 0 0 6.4001 374.42 460.21 Tm (1)Tj 0.05 Tc 11.2327 0 0 9.8 376.57 462.37 Tm (.,C0)Tj 0 Tc 6.4001 0 0 6.4001 397.4 460.21 Tm (2)Tj 0.703 0.338 Td (\225 )Tj EMC ET BT /T1_0 1 Tf 0.0116 Tc 9.8 0 0 9.8 407.96 462.37 Tm (Mixed )Tj 0.0225 Tc 3.063 0 Td (venous )Tj ET BT /Suspect <>BDC 0.255 0.255 0.243 rg /T1_0 1 Tf 0.05 Tc 11.8553 0 0 9.8 470.52 462.37 Tm (C0)Tj 0 Tc 6.4001 0 0 6.4001 485.96 460.21 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0432 Tc 9.8 0 0 9.8 492.86 462.37 Tm (and )Tj ET BT /Suspect <>BDC 0.165 0.169 0.157 rg /T1_2 1 Tf 0 Tc 10.2 0 0 10.2 511.98 462.37 Tm (0)Tj 6.1 0 0 6.1 520.06 459.96 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0247 Tc 9.8 0 0 9.8 295.46 451.56 Tm (pressure: )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.4383 0 0 9.8 336.6 451.56 Tm (\(PvC0)Tj 0 Tc 6.4001 0 0 6.4001 366.2 449.17 Tm (2)Tj 0.666 0.373 Td (, )Tj EMC /Suspect <>BDC 0.05 Tc 10.9713 0 0 9.8 376.03 451.56 Tm (Pv0)Tj 0 Tc 6.4001 0 0 6.4001 395 449.4 Tm (2)Tj 0.6 0.337 Td (\) )Tj EMC ET BT /T1_0 1 Tf -0.0006 Tc 9.8 0 0 9.8 405.59 451.56 Tm (were )Tj 0.0111 Tc 2.351 0 Td (respectively )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0343 Tc 9.8 0 0 9.8 480.6188 451.56 Tm (calculated )Tj EMC ET BT /T1_0 1 Tf 0.0382 Tc 9.8 0 0 9.8 295.4478 440.5252 Tm (by )Tj 0.046 Tc 1.356 0 Td (subtracting )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.2168 0 0 9.8 359.47 440.53 Tm (P\(a-ET\)C0)Tj /T1_1 1 Tf 0 Tc 6 0 0 6 408.91 438.37 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0316 Tc 9.8 0 0 9.8 415.81 440.53 Tm (from )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.8165 0 0 9.8 439.4 440.53 Tm (PP)Tj /T1_1 1 Tf 0 Tc 6 0 0 6 449.09 438.37 Tm (1)Tj /T1_0 1 Tf 0.05 Tc 11.2327 0 0 9.8 451.21 440.53 Tm (.,C0)Tj /T1_1 1 Tf 0 Tc 6 0 0 6 472.27 438.37 Tm (2)Tj /T1_0 1 Tf 0.05 Tc 10.0947 0 0 9.8 475.32 440.53 Tm (-and )Tj EMC /Suspect <>BDC 0.0484 Tc 9.8 0 0 9.8 497.72 440.53 Tm (P\(ET\255)Tj EMC /Suspect <>BDC 0.05 Tc 10.1518 0 0 9.8 295.58 429.49 Tm (a\)02 )Tj EMC ET BT /T1_0 1 Tf 0.0398 Tc 9.8 0 0 9.8 319.33 429.49 Tm (from )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9.8 0 0 9.8 343.879 429.49 Tm (P )Tj EMC /Suspect <>BDC 0.05 Tc 6.5905 0 0 6.2 349.93 429.49 Tm (pla)Tj 0 Tc 6.2 0 0 6.2 359.31 427.33 Tm (1)Tj 9.8 0 0 9.8 361.58 429.49 Tm (0)Tj 6.2 0 0 6.2 369.57 427.33 Tm (2 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.2192 0 0 9.8 377.06 429.49 Tm ([6]. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 11.8553 0 0 9.8 393.72 429.49 Tm (C0)Tj 0 Tc 6.2 0 0 6.2 408.93 427.56 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0396 Tc 9.8 0 0 9.8 416.54 429.49 Tm (arteriovenous )Tj 0.0455 Tc 6.294 0 Td (concentra\255)Tj 0.0379 Tc -18.629 -1.103 Td (tion )Tj 0.0111 Tc 2.074 0 Td (difference )Tj 0.0211 Tc 4.539 0 Td (was )Tj 0.0316 Tc 1.974 0 Td (calculated )Tj 0.0299 Tc 4.711 0 Td (with )Tj 0.0402 Tc 2.301 0 Td (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.8094 0 0 9.8 465.03 418.68 Tm (OLSZOWKA )Tj EMC ET BT /T1_2 1 Tf 0.05 Tc 9.8342 0 0 9.7 516.15 418.68 Tm (et )Tj -0.0266 Tc 9.7 0 0 9.7 295.14 407.65 Tm (a/. )Tj /T1_0 1 Tf 0.05 Tc 9.9045 0 0 9.8 309.59 407.65 Tm (nomogram )Tj 0.0183 Tc 9.8 0 0 9.8 360 407.65 Tm ([I7] )Tj 0.05 Tc 10.0265 0 0 9.8 379.34 407.65 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.8571 0 0 9.8 399.26 407.65 Tm (Qc )Tj EMC ET BT /T1_0 1 Tf 0.0211 Tc 9.8 0 0 9.8 414.95 407.65 Tm (was )Tj 0.0397 Tc 2.056 0 Td (then )Tj 0.0328 Tc 2.245 0 Td (calculated. )Tj 0.05 Tc 10.1189 0 0 9.8 506.79 407.65 Tm (The )Tj 0.0363 Tc 9.8 0 0 9.8 294.86 396.84 Tm (complete )Tj 0.0436 Tc 4.371 0 Td (procedure )Tj 0.0319 Tc 4.787 0 Td (for )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.8571 0 0 9.8 401.18 396.84 Tm (Qc )Tj EMC ET BT /T1_0 1 Tf 0.0434 Tc 9.8 0 0 9.8 417.02 396.84 Tm (evaluation )Tj 0.0211 Tc 4.981 0 Td (was )Tj 0.05 Tc 9.8048 0 0 9.8 485.91 396.84 Tm (obtained )Tj 10.4356 0 0 9.8 295.09 385.81 Tm (at )Tj 0.0302 Tc 9.8 0 0 9.8 305.92 385.81 Tm (least )Tj 0 Tc 2.25 0 Td (3 )Tj 0.017 Tc 0.744 0 Td (times )Tj 0.05 Tc 10.4356 0 0 9.8 360.13 385.81 Tm (at )Tj 0.0388 Tc 9.8 0 0 9.8 371.69 385.81 Tm (I5 )Tj 0.05 Tc 9.8937 0 0 9.8 383.02 385.81 Tm (min )Tj 0.0283 Tc 9.8 0 0 9.8 402.16 385.81 Tm (intervals )Tj 0.05 Tc 10.0265 0 0 9.8 441.02 385.81 Tm (and )Tj 0.0279 Tc 9.8 0 0 9.8 459.58 385.81 Tm (the )Tj 0.05 Tc 9.8764 0 0 9.8 475.18 385.81 Tm (mean )Tj 0.0239 Tc 9.8 0 0 9.8 501.1 385.81 Tm (value )Tj 0.029 Tc -21.011 -1.127 Td (retained. )Tj 0.0291 Tc 1.002 -1.103 Td (Wedge )Tj 0.0294 Tc 3.36 0 Td (pressure )Tj 0.05 Tc 10.0383 0 0 9.8 376.46 363.96 Tm (cannot )Tj -0.0028 Tc 9.8 0 0 9.8 409.69 363.96 Tm (be )Tj 0.0241 Tc 1.332 0 Td (systematically )Tj 0.05 Tc 9.8048 0 0 9.8 485.91 363.96 Tm (obtained )Tj 0.0299 Tc 9.8 0 0 9.8 294.95 352.93 Tm (with )Tj 0 Tc 2.268 0 Td (a )Tj 0.0354 Tc 0.841 0 Td (micro-catheter, )Tj 0.0414 Tc 7.004 0 Td (thus )Tj 0.0351 Tc 2.208 0 Td (preventing )Tj 0.0391 Tc 4.935 0 Td (calculation )Tj 0.05 Tc 10.8509 0 0 9.8 514.7 352.93 Tm (of )Tj 9.8624 0 0 9.8 294.98 342.12 Tm (pulmonary )Tj 0.0361 Tc 9.8 0 0 9.8 344.38 342.12 Tm (vascular )Tj 0.0197 Tc 3.846 0 Td (resistance. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.9759 0 0 9.8 428.36 342.12 Tm (Ppa/Qc )Tj EMC ET BT /T1_0 1 Tf 9.8143 0 0 9.8 462.71 342.12 Tm (ratio )Tj 0.0211 Tc 9.8 0 0 9.8 485.51 342.12 Tm (was )Tj 0.0263 Tc 1.887 0 Td (used )Tj 0.0332 Tc -21.339 -1.126 Td (instead )Tj 0.0117 Tc 3.402 0 Td (as )Tj 0.05 Tc 10.2654 0 0 9.8 339.98 331.09 Tm (an )Tj 0.0184 Tc 9.8 0 0 9.8 353.44 331.09 Tm (index )Tj 0.05 Tc 11.1292 0 0 9.8 379.33 331.09 Tm (of )Tj 9.8115 0 0 9.8 391.22 331.09 Tm (pulmonary )Tj 0.0361 Tc 9.8 0 0 9.8 440.86 331.09 Tm (vascular )Tj 0.0221 Tc 3.919 0 Td (resistance. )Tj 0.05 Tc 9.8256 0 0 9.8 304.72 320.05 Tm (The )Tj 0.0246 Tc 9.8 0 0 9.8 328.78 320.05 Tm (values )Tj 0.045 Tc 3.469 0 Td (are )Tj 0.0458 Tc 2.115 0 Td (reported )Tj 0.0117 Tc 4.472 0 Td (as )Tj 0.05 Tc 10.817 0 0 9.8 443.26 320.05 Tm (mean\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.7582 0 0 9.8 476.5 320.05 Tm (SEM. )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.4635 0 0 9.8 501.79 320.05 Tm (Data )Tj 0.0236 Tc 9.8 0 0 9.8 294.62 309.24 Tm (collected )Tj 0.05 Tc 10.0233 0 0 9.8 336.86 309.24 Tm (on )Tj 0.0427 Tc 9.8 0 0 9.8 352.46 309.24 Tm (entry )Tj 0.0075 Tc 2.752 0 Td (were )Tj 0.05 Tc 9.8385 0 0 9.8 403.58 309.24 Tm (compared )Tj 0.0319 Tc 9.8 0 0 9.8 450.61 309.24 Tm (for )Tj 0.0395 Tc 1.773 0 Td (homogeneity )Tj 0.0224 Tc -17.655 -1.126 Td (between )Tj 0.05 Tc 9.8357 0 0 9.8 333.1 298.21 Tm (the )Tj 0.0346 Tc 9.8 0 0 9.8 349.82 298.21 Tm (almitrine )Tj 0.05 Tc 9.8699 0 0 9.8 392.06 298.21 Tm (and )Tj 0.0349 Tc 9.8 0 0 9.8 411.62 298.21 Tm (placebo )Tj 0.0336 Tc 3.737 0 Td (groups, )Tj 0.028 Tc 3.633 0 Td (using )Tj 0.05 Tc 9.8357 0 0 9.8 509.98 298.21 Tm (the )Tj 0.0464 Tc 9.8 0 0 9.8 294.72 287.4 Tm (unpaired )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.836 0 0 9.8 338.7 287.4 Tm (Student )Tj EMC ET BT /T1_0 1 Tf 0.0261 Tc 9.8 0 0 9.8 377.5 287.4 Tm (t-test. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.1472 0 0 9.8 407.68 287.4 Tm (TO, )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.074 0 0 9.8 427.83 287.4 Tm (T6 )Tj 10.0265 0 0 9.8 445.58 287.4 Tm (and )Tj 11.098 0 0 9.8 467.42 287.4 Tm (Tl2 )Tj 10.2439 0 0 9.8 489.98 287.4 Tm (data )Tj -0.0017 Tc 9.8 0 0 9.8 514.96 287.4 Tm (in )Tj 0.0404 Tc -22.471 -1.126 Td (patients )Tj 0.0389 Tc 3.931 0 Td (completing )Tj 0.05 Tc 9.8357 0 0 9.8 386.14 276.37 Tm (the )Tj 0.0403 Tc 9.8 0 0 9.8 404.5 276.37 Tm (study )Tj 0.0075 Tc 2.928 0 Td (were )Tj 0.0341 Tc 2.538 0 Td (analysed )Tj 0.028 Tc 4.345 0 Td (using )Tj 0.0257 Tc -21.014 -1.127 Td (two-way )Tj 0.0212 Tc 4.057 0 Td (analysis )Tj 0.05 Tc 10.8509 0 0 9.8 371.42 265.33 Tm (of )Tj 0.0354 Tc 9.8 0 0 9.8 383.5 265.33 Tm (variance )Tj 0.0299 Tc 3.993 0 Td (with )Tj 0.0347 Tc 2.278 0 Td (repeated )Tj 0.0339 Tc 3.991 0 Td (measure\255)Tj 0.0352 Tc -19.347 -1.102 Td (ments )Tj 0.0335 Tc 2.89 0 Td (to )Tj 0.0367 Tc 1.176 0 Td (test )Tj 0.0319 Tc 1.803 0 Td (for )Tj 0.038 Tc 1.58 0 Td (between-group )Tj 0.0103 Tc 6.749 0 Td (differences )Tj 0.05 Tc 10.1832 0 0 9.8 481.34 254.53 Tm (and )Tj 0.0219 Tc 9.8 0 0 9.8 500.4 254.53 Tm (using )Tj 0 Tc -21.022 -1.127 Td (a )Tj 0.034 Tc 1.421 0 Td (one-way )Tj 0.0247 Tc 4.603 0 Td (analysis )Tj 0.05 Tc 10.8509 0 0 9.8 396.14 243.49 Tm (of )Tj 0.0319 Tc 9.8 0 0 9.8 413.98 243.49 Tm (variance )Tj 0.0381 Tc 4.556 0 Td (with )Tj 0.0417 Tc 2.841 0 Td (repeated )Tj 0.0375 Tc -19.593 -1.127 Td (measurements )Tj -0.035 Tc 9.439 0 0 9.8 357.37 232.45 Tm ([32] )Tj 0.05 Tc 9.8951 0 0 9.8 375.34 232.45 Tm (to )Tj 0.0286 Tc 9.8 0 0 9.8 386.38 232.45 Tm (test )Tj 0.0441 Tc 1.754 0 Td (for )Tj 0.038 Tc 1.553 0 Td (within-group )Tj 0.0287 Tc 5.893 0 Td (changes. )Tj 0.05 Tc 10.9512 0 0 9.8 515.68 232.45 Tm (If )Tj 0.0479 Tc 9.8 0 0 9.8 294.39 221.64 Tm (one )Tj 0.0269 Tc 2.212 0 Td (way )Tj 0.0247 Tc 2.415 0 Td (analysis )Tj 0.05 Tc 10.8509 0 0 9.8 379.82 221.64 Tm (of )Tj 0.0319 Tc 9.8 0 0 9.8 395.02 221.64 Tm (variance )Tj 0.0089 Tc 4.311 0 Td (was )Tj 0.0193 Tc 2.289 0 Td (significant )Tj 0.0279 Tc 5.106 0 Td (the )Tj 0.0243 Tc -21.999 -1.126 Td (different )Tj 0.0286 Tc 4.097 0 Td (test )Tj 0.0422 Tc 1.903 0 Td (day )Tj 0.0246 Tc 1.966 0 Td (values )Tj 0.0157 Tc 3.111 0 Td (were )Tj 0.0457 Tc 2.439 0 Td (further )Tj 0.05 Tc 9.8385 0 0 9.8 460.22 210.61 Tm (compared )Tj 0.0231 Tc 9.8 0 0 9.8 506.86 210.61 Tm (two )Tj -0.0108 Tc -21.67 -1.102 Td (by )Tj 0.0353 Tc 1.711 0 Td (two )Tj 0.0219 Tc 2.329 0 Td (using )Tj 0.0461 Tc 2.967 0 Td (Newman-Keuls' )Tj 0.0432 Tc 7.733 0 Td (method. )Tj 0.0286 Tc 4.269 0 Td (Statistical )Tj 0.0156 Tc -19.049 -1.127 Td (significance )Tj 0.0211 Tc 5.352 0 Td (was )Tj 0.0165 Tc 1.976 0 Td (defined )Tj 0.05 Tc 10.1194 0 0 9.8 400.46 188.77 Tm (at )Tj 0.0279 Tc 9.8 0 0 9.8 412.3 188.77 Tm (the )Tj 0 Tc 1.669 0 Td (p )Tj 0.255 0.255 0.243 rg /T1_1 1 Tf 10.1 0 0 10.1 435.68 188.77 Tm (< )Tj ET BT /Suspect <>BDC 0.165 0.169 0.157 rg /T1_0 1 Tf 0.0035 Tc 9.8 0 0 9.8 444.14 188.77 Tm (0.05 )Tj EMC ET BT /T1_0 1 Tf -0.0088 Tc 9.8 0 0 9.8 465.2786 188.77 Tm (level. )Tj /T1_4 1 Tf 0.0142 Tc 9.4 0 0 9.4 393.07 161.41 Tm (Results )Tj /T1_0 1 Tf 0.05 Tc 10.377 0 0 9.8 303.89 145.09 Tm (No )Tj 0.0217 Tc 9.8 0 0 9.8 321.46 145.09 Tm (significant )Tj 0.0127 Tc 4.83 0 Td (differences )Tj 0.0075 Tc 5.004 0 Td (were )Tj 0.0426 Tc 2.414 0 Td (found )Tj 0.0224 Tc 3 0 Td (between )Tj 0.0279 Tc 3.915 0 Td (the )Tj 0.0231 Tc -21.967 -1.127 Td (two )Tj 0.0463 Tc 2.198 0 Td (groups )Tj 0.0441 Tc 3.572 0 Td (for )Tj 0.0143 Tc 1.887 0 Td (clinical, )Tj 0.0422 Tc 3.977 0 Td (haemodynamic )Tj 0.05 Tc 10.0265 0 0 9.8 478.46 134.05 Tm (and )Tj 0.0067 Tc 9.8 0 0 9.8 500.53 134.05 Tm (func\255)Tj 0.0355 Tc -21.077 -1.127 Td (tional )Tj 0.05 Tc 10.0381 0 0 9.8 321.99 123.01 Tm (data, )Tj 0.0264 Tc 9.8 0 0 9.8 347.42 123.01 Tm (except )Tj 0.0441 Tc 3.134 0 Td (for )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.517 0 0 9.8 394.51 123.01 Tm (Paco)Tj 0 Tc 6.2 0 0 6.2 417.09 121.08 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0273 Tc 9.8 0 0 9.8 424.79 123.01 Tm (which )Tj 0.0089 Tc 2.963 0 Td (was )Tj 0.0163 Tc 1.995 0 Td (slightly )Tj 0.05 Tc 10.0045 0 0 9.8 508.09 123.01 Tm (but )Tj 0.0187 Tc 9.8 0 0 9.8 293.62 112.2 Tm (significantly )Tj 0.0388 Tc 5.695 0 Td (higher )Tj 0.0228 Tc 3.201 0 Td (in )Tj 0.0402 Tc 1.304 0 Td (the )Tj 0.0346 Tc 1.804 0 Td (almitrine )Tj 0.05 Tc 9.9115 0 0 9.8 454 112.2 Tm (group )Tj 0.0341 Tc 9.8 0 0 9.8 483.72 112.2 Tm (\(table )Tj 0.0024 Tc 2.919 0 Td (I\). )Tj 0.026 Tc -22.283 -1.102 Td (Five )Tj 0.0439 Tc 2.21 0 Td (patients )Tj 0.05 Tc 9.8907 0 0 9.8 352.47 101.4 Tm (dropped )Tj 10.261 0 0 9.8 391.82 101.4 Tm (out )Tj 10.8509 0 0 9.8 409.34 101.4 Tm (of )Tj 0.0279 Tc 9.8 0 0 9.8 421.42 101.4 Tm (the )Tj 0.0209 Tc 1.653 0 Td (study: )Tj 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)Tj 8.8 0 0 8.8 127.1 470.6496 Tm (M )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0285 Tc 8.9 0 0 8.9 127.1 459.8196 Tm (M* )Tj EMC /Suspect <>BDC 0 -1.245 TD (M* )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.0253 0 0 8.8 127.28 437.9096 Tm (9M )Tj 0.0227 Tc 8.9 0 0 8.9 173.6 723.4996 Tm (Age )Tj 0.05 Tc 9.3071 0 0 8.9 177.7 711.4596 Tm (yr )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0193 Tc 8.8 0 0 8.8 175.91 689.5396 Tm (50 )Tj EMC ET BT /T1_0 1 Tf -0.0177 Tc 8.8 0 0 8.8 176.1564 678.7068 Tm (62 )Tj -0.027 -1.259 Td (69 )Tj 0.0004 Tc -0.047 -1.232 Td (45 )Tj -0.0177 Tc 0.019 -1.258 Td (66 )Tj 0.0467 Tc -0.03 -1.259 Td (52 )Tj -0.035 Tc 8.7062 0 0 8.8 175.68 623.5596 Tm (68 )Tj 0.0193 Tc 8.8 0 0 8.8 175.18 612.4896 Tm (59 )Tj 0.05 Tc 8.8437 0 0 8.8 175.03 601.6496 Tm (44 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0097 Tc 8.8 0 0 8.8 175.2 590.8096 Tm (60 )Tj EMC ET BT /T1_0 1 Tf 0.0193 Tc 8.8 0 0 8.8 174.936 579.7392 Tm (53 )Tj 0.0027 Tc -2.052 -1.232 Td (57.1 )Tj 0 Tc 2.039 0 Td (\261 )Tj 0.235 0.235 0.223 rg 0.898 0 Td (2)Tj 0.341 0.341 0.329 rg 0.559 0 Td (.)Tj 0.149 0.149 0.137 rg 0.202 0 Td (7 )Tj -0.0177 Tc -1.616 -3.749 Td (69 )Tj 0.0278 Tc -0.047 -1.231 Td (49 )Tj -0.0177 Tc 0.047 -1.232 Td (66 )Tj 0.0193 Tc -0.03 -1.259 Td (56 )Tj 0 -1.231 TD (57 )Tj -0.027 -1.205 Td (57 )Tj 0.0467 Tc 0 -1.259 TD (52 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0371 Tc 8.8 0 0 8.8 174.9624 459.5664 Tm (60 )Tj EMC ET BT /T1_0 1 Tf -0.0177 Tc 8.8 0 0 8.8 174.9624 448.7248 Tm (65 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.0675 0 0 8.8 153.25 437.6596 Tm (59.0\2612)Tj 0.341 0.341 0.329 rg 0 Tc 8.8 0 0 8.8 184.03 437.6596 Tm (.)Tj 0.149 0.149 0.137 rg 0.207 0 Td (2 )Tj EMC ET BT /T1_0 1 Tf 0.0049 Tc 8.9 0 0 8.9 223.19 722.7696 Tm (FEVI )Tj /T1_1 1 Tf 0.0477 Tc 11.8 0 0 11.8 271.34 723.4996 Tm (vc )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0 Tc 8.5 0 0 8.5 230.31 711.9396 Tm (I )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.0259 Tc 8.8 0 0 8.8 222.89 689.7796 Tm (0.77 )Tj EMC ET BT /T1_0 1 Tf 0.0001 Tc 8.8 0 0 8.8 270.85 689.542 Tm (2.1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0168 Tc 8.8 0 0 8.8 222.89 678.7092 Tm (0.69 )Tj EMC ET BT /T1_0 1 Tf -0.001 Tc 8.8 0 0 8.8 271.3164 678.7092 Tm (1.8 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0123 Tc 8.8 0 0 8.8 223.4004 667.63 Tm (1.01 )Tj EMC ET BT /T1_0 1 Tf 0.0091 Tc 8.8 0 0 8.8 270.7972 667.63 Tm (3.1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 222.89 656.5508 Tm (0)Tj 0.341 0.341 0.329 rg 0.565 0 Td (.)Tj 0.149 0.149 0.137 rg 0.0004 Tc 0.208 0 Td (43 )Tj EMC ET BT /T1_0 1 Tf -0.001 Tc 8.8 0 0 8.8 271.3252 656.7884 Tm (1.7 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0259 Tc 8.8 0 0 8.8 222.8988 645.4804 Tm (0.62 )Tj EMC ET BT /T1_0 1 Tf -0.001 Tc 8.8 0 0 8.8 271.3252 645.718 Tm (1.7 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.035 Tc 8.8 0 0 8.8 222.6524 634.6388 Tm (0.70 )Tj EMC ET BT /T1_0 1 Tf 0.0264 Tc 8.8 0 0 8.8 271.0788 634.4012 Tm (1.9 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0076 Tc 8.8 0 0 8.8 222.89 623.7972 Tm (0.59 )Tj EMC ET BT /T1_0 1 Tf 0.0127 Tc 8.8 0 0 8.8 271.0788 623.7972 Tm (1.6 )Tj -0.0031 Tc -5.445 -1.258 Td (1.23 )Tj 0.0412 Tc 5.392 0 Td (2.4 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0168 Tc 8.8 0 0 8.8 222.6524 601.6476 Tm (0.59 )Tj EMC ET BT /T1_0 1 Tf 0.0127 Tc 8.8 0 0 8.8 271.0788 601.6476 Tm (1.7 )Tj -0.0123 Tc -5.473 -1.203 Td (1.51 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.8025 0 0 8.8 270.32 591.0596 Tm (3.0 )Tj EMC /Suspect <>BDC 0.0168 Tc 8.8 0 0 8.8 222.41 579.7396 Tm (0.49 )Tj EMC /Suspect <>BDC 0.0412 Tc 5.45 0.027 Td (2.0 )Tj EMC /Suspect <>BDC 0.05 Tc 9.3027 0 0 8.8 205.31 568.6596 Tm (0.78\2610.10 )Tj EMC /Suspect <>BDC 9.2495 0 0 8.8 255.44 568.8996 Tm (2.09\2610.1 )Tj EMC ET BT /T1_0 1 Tf 0.0151 Tc 8.8 0 0 8.8 218.1 535.9096 Tm (1.79 )Tj 0.0091 Tc 5.907 0 Td (3.1 )Tj -0.0031 Tc -5.88 -1.203 Td (1.78 )Tj 0.0365 Tc 5.88 0 Td (3.8 )Tj 0.0151 Tc -5.88 -1.259 Td (1.14 )Tj 0.0091 Tc 5.88 0 Td (3.1 )Tj 0.0341 Tc -5.96 -1.259 Td (2.54 )Tj 0.235 0.235 0.223 rg 0.0394 Tc 5.94 0.027 Td (4.3 )Tj ET BT /Suspect <>BDC 0.149 0.149 0.137 rg /T1_0 1 Tf 0.0341 Tc 8.8 0 0 8.8 217.6336 492.332 Tm (2.00 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.8025 0 0 8.8 270.08 492.3296 Tm (3.6 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0076 Tc 8.8 0 0 8.8 217.84 481.4896 Tm (0.65 )Tj EMC ET BT /T1_0 1 Tf 0.0001 Tc 8.8 0 0 8.8 270.3672 481.4896 Tm (2.1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0168 Tc 8.8 0 0 8.8 217.5936 470.648 Tm (0.68 )Tj EMC ET BT /T1_0 1 Tf 0.0138 Tc 8.8 0 0 8.8 270.3672 470.4104 Tm (2.8 )Tj -0.0031 Tc -5.94 -1.203 Td (1.23 )Tj 0.0412 Tc 5.94 -0.027 Td (2.4 )Tj 0.0151 Tc -5.94 -1.232 Td (1.22 )Tj 0.05 Tc 8.8025 0 0 8.8 270.32 448.7396 Tm (3.4 )Tj -0.0123 Tc 8.8 0 0 8.8 204.62 437.9096 Tm (1.45 )Tj 0 Tc 1.949 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0106 Tc 8.8 0 0 8.8 229.392 437.9096 Tm (0.21 )Tj EMC ET BT /T1_0 1 Tf 0.0219 Tc 8.8 0 0 8.8 252.0256 437.9096 Tm (3.18 )Tj 0 Tc 2.064 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0015 Tc 8.8 0 0 8.8 277.572 437.9096 Tm (0.23 )Tj EMC ET BT /T1_0 1 Tf 0.0393 Tc 8.9 0 0 8.9 327.66 723.4996 Tm (TLC )Tj 0.0257 Tc 4.816 0 Td (TLC )Tj 0.05 Tc 9.2229 0 0 8.9 415.35 723.2596 Tm (FEV/VC )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.9713 0 0 8.9 471.21 723.4996 Tm (Pao)Tj 0 Tc 6.7 0 0 6.7 485.42 720.1296 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.0447 0 0 8.9 520.09 723.4996 Tm (Paco)Tj /T1_1 1 Tf 0 Tc 5.5001 0 0 5.5001 538.87 720.1296 Tm (2 )Tj /T1_0 1 Tf 0.041 Tc 8.9 0 0 8.9 362.32 711.6996 Tm (%predicted )Tj 0 Tc 7.089 0.054 Td (% )Tj 0.05 Tc 9.0409 0 0 8.9 470.75 711.6996 Tm (kPa )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0356 Tc 8.9 0 0 8.9 522.28 711.4596 Tm (kPa )Tj EMC ET BT /T1_0 1 Tf 0.0394 Tc 8.8 0 0 8.8 327.7 689.7796 Tm (4.2 )Tj -0.0177 Tc 5.384 0 Td (75 )Tj 0.0494 Tc 5.39 0 Td (37 )Tj 0.0086 Tc 5.499 0 Td (6.53 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.8 0 0 8.8 520.2704 689.542 Tm (6.40 )Tj EMC ET BT /T1_0 1 Tf 0.0228 Tc 8.8 0 0 8.8 327.6296 678.7092 Tm (3.3 )Tj -0.0177 Tc 5.417 0 Td (67 )Tj 0.022 Tc 5.365 0.027 Td (38 )Tj 0.0178 Tc 5.474 0 Td (7.73 )Tj -0.0005 Tc 5.608 -0.027 Td (6.13 )Tj 0.0488 Tc -21.866 -1.259 Td (5.4 )Tj 0.0374 Tc 5.393 -0.027 Td (92 )Tj 0.022 Tc 5.391 0.055 Td (33 )Tj 0.0301 Tc 5.47 0 Td (5.47 )Tj 0.021 Tc 5.582 -0.027 Td (5.93 )Tj 0.003 Tc -21.833 -1.232 Td (7.1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0028 Tc 8.8 0 0 8.8 371.0048 656.7972 Tm (109 )Tj EMC ET BT /T1_0 1 Tf 0.004 Tc 8.8 0 0 8.8 422.5552 657.0436 Tm (25 )Tj 0 Tc 5.489 -0.028 Td (8)Tj 0.4 0.404 0.392 rg 0.543 0 Td (.)Tj 0.149 0.149 0.137 rg 0.0018 Tc 0.287 0 Td (17 )Tj 0.021 Tc 4.727 0 Td (5.47 )Tj 0.0257 Tc -21.853 -1.258 Td (4.9 )Tj 0.0091 Tc 8.9 0 0 8.9 375.25 645.7196 Tm (84 )Tj 0.0494 Tc 8.8 0 0 8.8 422.51 645.9596 Tm (36 )Tj 0.0087 Tc 5.473 -0.027 Td (9.33 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0086 Tc 8.8 0 0 8.8 520.2692 645.722 Tm (6.00 )Tj EMC ET BT /T1_0 1 Tf 0.0304 Tc 8.8 0 0 8.8 327.6196 634.6428 Tm (6.4 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0165 Tc 8.8 0 0 8.8 371.0124 634.6428 Tm (103 )Tj EMC ET BT /T1_0 1 Tf 0.0494 Tc 8.8 0 0 8.8 422.2724 634.8804 Tm (37 )Tj 0.0178 Tc 5.501 0 Td (7.67 )Tj 0 Tc 5.578 -0.027 Td (5)Tj 0.4 0.404 0.392 rg 0.568 0 Td (.)Tj 0.149 0.149 0.137 rg 0.01 Tc 0.201 0 Td (93 )Tj 0.0257 Tc -22.651 -1.232 Td (4.8 )Tj -0.0345 Tc 5.46 0 Td (89 )Tj 0.05 Tc 9.0322 0 0 8.8 422.26 624.0496 Tm (37 )Tj 0.003 Tc 8.8 0 0 8.8 470.86 624.0496 Tm (8.53 )Tj 0.0027 Tc 5.558 -0.028 Td (5.73 )Tj 0.0352 Tc -21.864 -1.231 Td (5.8 )Tj -0.0174 Tc 5.393 -0.027 Td (95 )Tj -0.035 Tc 8.796 0 0 8.8 422.49 612.9696 Tm (51 )Tj 0.0178 Tc 8.8 0 0 8.8 470.44 612.9696 Tm (7.87 )Tj 0.0118 Tc 5.578 -0.027 Td (5.93 )Tj 0.0394 Tc -21.882 -1.232 Td (4.8 )Tj -0.0072 Tc 5.46 0 Td (86 )Tj 0.022 Tc 5.369 0 Td (35 )Tj 0.0301 Tc 5.47 0 Td (5.99 )Tj 0.021 Tc 5.582 -0.027 Td (5.99 )Tj 0 Tc -21.882 -1.232 Td (4)Tj 0.341 0.341 0.329 rg 0.586 0 Td (.)Tj 0.149 0.149 0.137 rg 0.227 0 Td (9 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0072 Tc 8.8 0 0 8.8 375.004 591.0576 Tm (80 )Tj EMC /Suspect <>BDC 0.05 Tc 9.0082 0 0 8.8 422.24 591.0596 Tm (50 )Tj EMC ET BT /T1_0 1 Tf 0.003 Tc 8.8 0 0 8.8 470.61 591.2996 Tm (8.51 )Tj 0.021 Tc 5.559 -0.027 Td (5.72 )Tj 0.05 Tc 8.9675 0 0 8.8 327.13 579.7396 Tm (5.4 )Tj -0.0174 Tc 8.8 0 0 8.8 374.59 579.9796 Tm (95 )Tj 0.004 Tc 5.424 0.027 Td (25 )Tj 0.036 Tc 5.466 -0.027 Td (6.92 )Tj -0.0005 Tc 5.582 0 Td (6.65 )Tj 0.021 Tc -24.574 -1.259 Td (5.18 )Tj 0 Tc 2.066 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0106 Tc 8.8 0 0 8.8 328.8564 568.9004 Tm (0.31 )Tj EMC ET BT /T1_0 1 Tf 0.003 Tc 8.8 0 0 8.8 354.0772 568.9004 Tm (88.7 )Tj 0 Tc 1.986 0 Td (\261 )Tj 0.0228 Tc 0.837 0 Td (3.7 )Tj 0.031 Tc 2.6 0.027 Td (36.7 )Tj 0 Tc 2.062 0 Td (\261 )Tj -0.0135 Tc 0.87 0 Td (2.5 )Tj 0.0269 Tc 2.541 -0.027 Td (7.52 )Tj 0 Tc 2.063 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0076 Tc 8.8 0 0 8.8 475.7372 568.9004 Tm (0.35 )Tj EMC ET BT /T1_0 1 Tf 0.0118 Tc 8.8 0 0 8.8 498.5732 568.9004 Tm (5.99 )Tj 0 Tc 2.011 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0259 Tc 8.8 0 0 8.8 523.6532 568.9004 Tm (0.10 )Tj EMC ET BT /T1_0 1 Tf 0.0215 Tc 8.8 0 0 8.8 327.1228 536.1468 Tm (5.7 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0382 Tc 8.8 0 0 8.8 372.4516 536.1468 Tm (106 )Tj EMC ET BT /T1_0 1 Tf 0.0193 Tc 8.8 0 0 8.8 422.0044 536.1468 Tm (58 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0213 Tc 8.8 0 0 8.8 470.6068 536.1468 Tm (8.40 )Tj EMC /Suspect <>BDC 0.0301 Tc 5.395 -0.027 Td (5.20 )Tj EMC ET BT /T1_0 1 Tf 0.0304 Tc 8.8 0 0 8.8 327.3692 525.3228 Tm (6.2 )Tj -0.0174 Tc 5.611 0 Td (91 )Tj 0.05 Tc 9.0764 0 0 8.8 421.85 525.3196 Tm (47 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0213 Tc 8.8 0 0 8.8 470.61 525.5596 Tm (8.80 )Tj EMC ET BT /T1_0 1 Tf 0.0147 Tc 8.8 0 0 8.8 516.9684 525.322 Tm (4.87 )Tj 0.0352 Tc -21.573 -1.232 Td (5.7 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.9265 0 0 8.8 377 514.4796 Tm (90 )Tj EMC ET BT /T1_0 1 Tf 9.0322 0 0 8.8 422.02 514.4796 Tm (37 )Tj 0.0179 Tc 8.8 0 0 8.8 470.43 514.4796 Tm (9.33 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0118 Tc 8.8 0 0 8.8 518.3284 514.242 Tm (5.07 )Tj EMC ET BT /T1_0 1 Tf 0.044 Tc 8.8 0 0 8.8 327.1572 503.4004 Tm (7.2 )Tj 0.0245 Tc 5.175 0 Td (126 )Tj 0.0467 Tc 5.631 0 Td (59 )Tj 0.0121 Tc 5.495 0 Td (8.33 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0118 Tc 8.8 0 0 8.8 518.3284 503.4004 Tm (5.07 )Tj EMC ET BT /T1_0 1 Tf 0.0167 Tc 8.8 0 0 8.8 327.3772 492.33 Tm (6.2 )Tj 0.01 Tc 5.639 0 Td (93 )Tj 0.0467 Tc 5.142 0.027 Td (56 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0304 Tc 8.8 0 0 8.8 470.1308 492.5676 Tm (8.00 )Tj EMC /Suspect <>BDC 0.0118 Tc 5.423 0 Td (5.07 )Tj EMC /Suspect <>BDC 0.05 Tc 9.0209 0 0 8.8 326.97 481.7296 Tm (4.0 )Tj EMC ET BT /T1_0 1 Tf 0.0467 Tc 8.8 0 0 8.8 376.98 481.7296 Tm (57 )Tj 0.022 Tc 5.147 0.027 Td (31 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0451 Tc 8.8 0 0 8.8 469.952 481.7296 Tm (7.20 )Tj EMC ET BT /T1_0 1 Tf 0.0118 Tc 8.8 0 0 8.8 517.8504 481.7296 Tm (5.87 )Tj 0.0167 Tc -21.669 -1.259 Td (7.1 )Tj 0.0245 Tc 5.175 0 Td (116 )Tj 0.05 Tc 8.8746 0 0 8.8 422.32 470.8996 Tm (24 )Tj 0.0269 Tc 8.8 0 0 8.8 469.95 470.8996 Tm (7.87 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0238 Tc 8.8 0 0 8.8 517.69 470.6532 Tm (4.80 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.8405 0 0 8.8 326.97 459.8196 Tm (4.9 )Tj 0.0476 Tc 8.8 0 0 8.8 377.18 459.8196 Tm (82 )Tj -0.035 Tc 8.796 0 0 8.8 422.49 459.8196 Tm (51 )Tj 0.0269 Tc 8.8 0 0 8.8 469.95 460.0596 Tm (7.85 )Tj 0.0301 Tc 5.443 -0.027 Td (5.32 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.9025 0 0 8.8 327.16 448.9796 Tm (7.0 )Tj EMC ET BT /T1_0 1 Tf 0.0245 Tc 8.8 0 0 8.8 372.7 448.9796 Tm (119 )Tj 0.05 Tc 9.0322 0 0 8.8 422.26 448.9796 Tm (36 )Tj 0.0301 Tc 8.8 0 0 8.8 469.93 448.9796 Tm (5.85 )Tj 0.0147 Tc 5.427 0 Td (4.79 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0086 Tc 8.8 0 0 8.8 302.5804 437.6628 Tm (6.00 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 320.2596 437.6628 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0259 Tc 8.8 0 0 8.8 327.6428 437.6628 Tm (0.36 )Tj EMC ET BT /T1_0 1 Tf -0.0004 Tc 8.8 0 0 8.8 352.6788 437.9092 Tm (97.8 )Tj 0.05 Tc 9.7971 0 0 8.8 370.35 437.9096 Tm (\2617.2 )Tj 9.0764 0 0 8.8 402.83 437.9096 Tm (44)Tj 0.341 0.341 0.329 rg 0 Tc 8.8 0 0 8.8 412.79 437.9096 Tm (.)Tj 0.149 0.149 0.137 rg 0.201 0 Td (3 )Tj 0.05 Tc 9.425 0 0 8.8 421.16 437.9096 Tm (\2614.3 )Tj 0.0178 Tc 8.8 0 0 8.8 446.6 437.9096 Tm (7.96 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.3741 0 0 8.8 464.74 437.9096 Tm (\2610.33 )Tj EMC ET BT /T1_0 1 Tf 9.285 0 0 8.8 495.2 437.9096 Tm (5.12\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0106 Tc 8.8 0 0 8.8 520.52 437.9096 Tm (0.11 )Tj EMC ET BT /T1_0 1 Tf -0.0045 Tc 8.9 0 0 8.9 69.87 423.2196 Tm (No )Tj 0.0192 Tc 1.74 0 Td (significant )Tj 0.009 Tc 5.118 0 Td (differences )Tj 0.0129 Tc 5.311 0 Td (were )Tj 0.0004 Tc 2.751 0 Td (found )Tj 0.0241 Tc 3.097 0 Td (between )Tj -0.0136 Tc 4.244 0 Td (the )Tj -0.0313 Tc 2.002 0 Td (two )Tj 0.0051 Tc 1.997 0 Td (groups )Tj 0.0131 Tc 3.299 0 Td (except )Tj 0.0162 Tc 3.138 0 Td (for )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.0447 0 0 8.9 376.09 423.2196 Tm (Paco)Tj 0 Tc 6.2 0 0 6.2 395.12 419.8396 Tm (2)Tj 0.534 0.545 Td (\225 )Tj EMC ET BT /T1_0 1 Tf 0.015 Tc 8.9 0 0 8.9 404.47 423.2196 Tm (TLC: )Tj -0.0032 Tc 2.82 0 Td (total )Tj 0.026 Tc 2.266 0 Td (lung )Tj 0.0087 Tc 2.353 0 Td (capacity; )Tj -0.0175 Tc 4.202 0 Td (VC: )Tj 0.0178 Tc 2.191 0 Td (vital )Tj 0.0053 Tc -51.415 -1.326 Td (capacity; )Tj 0.0251 Tc 4.145 0 Td (FEV)Tj 0 Tc 6.2 0 0 6.2 124.28 407.7996 Tm (1)Tj 0.476 0.584 Td (: )Tj 0.0052 Tc 8.9 0 0 8.9 133.79 411.4196 Tm (forced )Tj 0.015 Tc 3.057 0 Td (expiratory )Tj 0.0186 Tc 4.69 0 Td (volume )Tj /T1_1 1 Tf 0.05 Tc 9.1706 0 0 8.8 233.88 411.4196 Tm (in )Tj /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 245.79 411.4196 Tm (1 )Tj 0.0006 Tc 0.94 0 Td (second; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0293 Tc 8.9 0 0 8.9 285.7866 411.4196 Tm (Pao)Tj 0 Tc 6.2 0 0 6.2 300.01 407.7996 Tm (2)Tj 0.49 0.584 Td (; )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.9287 0 0 8.9 309.63 411.4196 Tm (Paco)Tj 0 Tc 6.2 0 0 6.2 328.66 407.7996 Tm (2)Tj 0.485 0.584 Td (: )Tj 0.0161 Tc 8.9 0 0 8.9 338 411.4196 Tm (oxygen )Tj 0.0281 Tc 3.463 0 Td (and )Tj 0.0284 Tc 1.921 0 Td (carbon )Tj 0.0116 Tc 3.274 0 Td (dioxide )Tj 0.0079 Tc 3.335 0 Td (tensions )Tj /T1_1 1 Tf 0.05 Tc 9.1706 0 0 8.8 478.78 411.4196 Tm (in )Tj /T1_0 1 Tf 0.0037 Tc 8.9 0 0 8.9 490.18 411.4196 Tm (arterial )Tj 0.0052 Tc 3.285 0 Td (blood, )Tj 0.0049 Tc -50.482 -1.353 Td (*:drop-outs. )Tj -0.0267 Tc 10.3 0 0 10.3 67.65 372.4096 Tm (was )Tj 0.015 Tc 1.91 0 Td (lost )Tj 0.0436 Tc 1.923 0 Td (to )Tj 0.0017 Tc 1.207 0 Td (follow-up )Tj 0.05 Tc 11.1051 0 0 10.3 164.84 372.4096 Tm (at )Tj 0.0149 Tc 10.3 0 0 10.3 177.6 372.4096 Tm (four )Tj 0.0248 Tc 2.16 0 Td (months )Tj 0.0101 Tc 3.496 0 Td (\(placebo\) )Tj 0.0322 Tc 4.281 0 Td (and )Tj 0.0018 Tc -20.619 -1.076 Td (one )Tj 0.0238 Tc 1.725 0 Td (stopped )Tj 0.0224 Tc 3.565 0 Td (the )Tj 0.0142 Tc 1.567 0 Td (tablets )Tj 0.0131 Tc 2.959 0 Td (\(placebo\) )Tj 0.05 Tc 10.4705 0 0 10.3 211.56 361.3296 Tm (at )Tj 0.0251 Tc 10.3 0 0 10.3 222.64 361.3296 Tm (one )Tj 0.0464 Tc 1.761 0 Td (month )Tj 0.05 Tc 11.1664 0 0 10.3 272 361.3296 Tm (of )Tj -0.0083 Tc 10.3 0 0 10.3 283.65 361.3296 Tm (his )Tj -0.0092 Tc -20.979 -1.076 Td (own )Tj 0.0216 Tc 1.963 0 Td (accord )Tj 0.0267 Tc 3.014 0 Td (\(attributing )Tj 0.05 Tc 10.3003 0 0 10.3 170.15 350.2496 Tm (cor )Tj 0.0176 Tc 10.3 0 0 10.3 186.88 350.2496 Tm (pulmonale )Tj 0.0436 Tc 4.602 0 Td (to )Tj 0.0107 Tc 1.121 0 Td (the )Tj 0.002 Tc 1.544 0 Td (tablets\). )Tj 0.0067 Tc -18.846 -1.028 Td (Fifteen )Tj 0.0218 Tc 3.606 0 Td (patients )Tj 0.0054 Tc 3.961 0 Td (\(eight )Tj 0.0185 Tc 3.065 0 Td (almitrine )Tj 0.0064 Tc 4.453 0 Td (bismesylate )Tj 0.0322 Tc 5.506 0 Td (and )Tj -0.0189 Tc -20.624 -1.076 Td (seven )Tj 0.011 Tc 2.541 0 Td (placebo\) )Tj 0.0144 Tc 3.846 0 Td (completed )Tj 0.0224 Tc 4.637 0 Td (the )Tj 0.0081 Tc 1.601 0 Td (study. )Tj -0.0039 Tc -11.7 -1.076 Td (All )Tj 0.0218 Tc 1.944 0 Td (patients )Tj -0.0027 Tc 3.901 0 Td (receiving )Tj 0.0126 Tc 4.34 0 Td (almitrine )Tj 0.0041 Tc 4.407 0 Td (bismesylate )Tj -0.035 Tc 10.1498 0 0 10.3 282.84 317.4996 Tm (ex\255)Tj 0.0008 Tc 10.3 0 0 10.3 67.2 306.4296 Tm (pressed )Tj 0.0224 Tc 3.41 0 Td (the )Tj 0.0118 Tc 1.648 0 Td (sensation )Tj 0.05 Tc 11.1664 0 0 10.3 162.67 306.4296 Tm (of )Tj -0.0134 Tc 10.3 0 0 10.3 175.67 306.4296 Tm (feeling )Tj 0.0097 Tc 3.122 0 Td (better. )Tj 0.0138 Tc 3.033 0 Td (Five )Tj 0.0185 Tc 2.204 0 Td (patients )Tj 0.0117 Tc -18.925 -1.076 Td (considerably )Tj 0.0129 Tc 5.683 0 Td (improved )Tj 0.0224 Tc 4.401 0 Td (their )Tj 0.0053 Tc 2.374 0 Td (score )Tj 0.05 Tc 10.5246 0 0 10.3 221.44 295.3496 Tm (on )Tj 0.0107 Tc 10.3 0 0 10.3 237.41 295.3496 Tm (the )Tj 0.0198 Tc 1.699 0 Td (dyspnoea )Tj -0.0138 Tc -18.24 -1.052 Td (scale, )Tj 0.0438 Tc 2.762 0 Td (and )Tj 0.0101 Tc 2.136 0 Td (three )Tj 0.03 Tc 2.587 0 Td (others )Tj 0.0077 Tc 3.133 0 Td (described )Tj 0.05 Tc 10.3527 0 0 10.3 222.49 284.5096 Tm (no )Tj 0.0084 Tc 10.3 0 0 10.3 239.26 284.5096 Tm (change. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0203 Tc 10.3 0 0 10.3 277.782 284.5096 Tm (One )Tj EMC ET BT /T1_0 1 Tf 0.024 Tc 10.3 0 0 10.3 66.9616 273.4371 Tm (patient )Tj -0.0033 Tc 3.223 0 Td (was )Tj 0.0182 Tc 1.932 0 Td (able )Tj 0.0202 Tc 2.112 0 Td (to )Tj 0.0298 Tc 1.181 0 Td (stop )Tj 0.0104 Tc 2.132 0 Td (domiciliary )Tj 0 Tc 5.096 0 Td (oxygen )Tj 0.0232 Tc 3.327 0 Td (therapy )Tj 0.0205 Tc -18.991 -1.052 Td (and )Tj 0.0363 Tc 1.847 0 Td (another )Tj -0.0033 Tc (was )Tj 0.0027 Tc 5.448 0 Td (able )Tj 0.0436 Tc 2.018 0 Td (to )Tj 0.0376 Tc 1.181 0 Td (stop )Tj 0.0104 Tc 2.085 0 Td (domiciliary )Tj 0.0167 Tc 5.057 0 Td (ventilatory )Tj -0.0024 Tc -17.636 -1.076 Td (assistance, )Tj 0.0421 Tc 4.547 0 Td (both )Tj 0.0392 Tc 2.163 0 Td (at )Tj 0.0224 Tc 1.036 0 Td (their )Tj 0.0131 Tc 2.152 0 Td (request. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.1931 0 0 10.3 205.46 251.5196 Tm (Six )Tj EMC ET BT /T1_0 1 Tf 0.0252 Tc 10.3 0 0 10.3 220.83 251.5196 Tm (patients )Tj -0.0057 Tc 3.55 0 Td (receiving )Tj 0.006 Tc -18.489 -1.051 Td (placebo )Tj 0.0038 Tc 3.751 0 Td (expressed )Tj 0.235 0.235 0.223 rg 0.05 Tc 4.607 0 Td (an )Tj 0.149 0.149 0.137 rg 0.0088 Tc 1.637 0 Td (overall )Tj 0.0148 Tc 3.479 0 Td (sensation )Tj 0.05 Tc 11.1664 0 0 10.3 251.77 240.6896 Tm (of )Tj -0.0173 Tc 10.3 0 0 10.3 267.18 240.6896 Tm (feeling )Tj 0.0058 Tc -19.439 -1.076 Td (better. )Tj 0.0138 Tc 2.87 0 Td (Five )Tj 0.05 Tc 11.4455 0 0 10.3 117.64 229.6096 Tm (of )Tj -0.0039 Tc 10.3 0 0 10.3 129.05 229.6096 Tm (these )Tj 0.0252 Tc 2.294 0 Td (patients )Tj 0.0163 Tc 3.545 0 Td (improved )Tj 0.0224 Tc 4.19 0 Td (their )Tj 0.0231 Tc 2.144 0 Td (dyspnoea )Tj -0.013 Tc -18.216 -1.076 Td (score, )Tj 0.0251 Tc 2.856 0 Td (one )Tj 0.0048 Tc 1.987 0 Td (described )Tj 0.032 Tc 4.381 0 Td (no )Tj 0.018 Tc 1.557 0 Td (change )Tj 0.0322 Tc 3.437 0 Td (and )Tj 0.0251 Tc 2.034 0 Td (one )Tj 0.0077 Tc 1.987 0 Td (described )Tj -0.0053 Tc -18.274 -1.075 Td (worse )Tj 0.0153 Tc 3.054 0 Td (dyspnoea. )Tj 0.05 Tc 10.601 0 0 10.3 148.14 207.4596 Tm (No )Tj 0.0331 Tc 10.3 0 0 10.3 168.82 207.4596 Tm (particular )Tj -0.0058 Tc 4.777 0 Td (side )Tj -0.0116 Tc 2.272 0 Td (effects )Tj -0.0143 Tc 3.282 0 Td (were )Tj 0.0052 Tc -20.254 -1.076 Td (observed )Tj 0.0107 Tc 3.976 0 Td (in )Tj 0.0029 Tc 1.151 0 Td (this )Tj 0.0035 Tc 1.812 0 Td (study. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.4918 0 0 10.3 76.05 185.7796 Tm (Pao)Tj 0 Tc 6.8001 0 0 6.8001 93.15 183.6196 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0322 Tc 10.3 0 0 10.3 103.92 185.7796 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0393 Tc 10.3 0 0 10.3 126.4667 185.7796 Tm (Sao)Tj 0 Tc 6.8001 0 0 6.8001 143 183.3796 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0173 Tc 10.3 0 0 10.3 153.37 185.7796 Tm (time )Tj 0.0104 Tc 2.471 0 Td (courses )Tj -0.0143 Tc 3.702 0 Td (were )Tj -0.001 Tc 2.559 0 Td (significantly )Tj 0.0038 Tc -17.203 -1.075 Td (different )Tj 0.0041 Tc 3.916 0 Td (between )Tj 0.0176 Tc 3.778 0 Td (groups. )Tj 0.0383 Tc 3.553 0 Td (The )Tj -0.009 Tc 2.111 0 Td (values )Tj 0.0229 Tc 2.963 0 Td (improved )Tj -0.0237 Tc 4.436 0 Td (sig\255)Tj -0.004 Tc -20.724 -1.076 Td (nificantly )Tj 0.05 Tc 10.7878 0 0 10.3 109.21 163.6296 Tm (at )Tj 0.0286 Tc 10.3 0 0 10.3 120.79 163.6296 Tm (T6 )Tj 0.235 0.235 0.223 rg 0.0322 Tc 1.472 0 Td (and )Tj 0.05 Tc 11.2988 0 0 10.3 154.98 163.6296 Tm (Tl2 )Tj 0.149 0.149 0.137 rg -0.0127 Tc 10.3 0 0 10.3 175.46 163.6296 Tm (in )Tj 0.0224 Tc 1.128 0 Td (the )Tj 0.0155 Tc 1.605 0 Td (almitrine )Tj 0.0017 Tc 4.103 0 Td (bismesylate )Tj 0.0166 Tc -17.427 -1.076 Td (group )Tj 0.028 Tc 2.687 0 Td (compared )Tj -0.0031 Tc 4.473 0 Td (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.2143 0 0 10.3 151.15 152.5496 Tm (TO )Tj EMC ET BT /T1_0 1 Tf 0.0173 Tc 10.3 0 0 10.3 165.9 152.5496 Tm (with )Tj 0.032 Tc 2.15 0 Td (no )Tj 0.018 Tc 1.324 0 Td (change )Tj 0.0375 Tc 3.211 0 Td (throughout )Tj -0.0127 Tc 5.044 0 Td (in )Tj -0.001 Tc -21.385 -1.051 Td (the )Tj 0.0138 Tc 1.57 0 Td (placebo )Tj 0.0194 Tc 3.544 0 Td (group. )Tj 0.0383 Tc 3.062 0 Td (The )Tj 0.0216 Tc 1.978 0 Td (Newman-Keuls' )Tj 0.0219 Tc 7.1 0 Td (test )Tj 0.0068 Tc 1.788 0 Td (showed )Tj -0.0029 Tc -19.053 -1.052 Td (significant )Tj 0.0207 Tc 4.728 0 Td (improvement )Tj 0.05 Tc 11.1664 0 0 10.3 177.85 130.8796 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.4918 0 0 10.3 192.59 130.8796 Tm (Pao)Tj 0 Tc 6.5001 0 0 6.5001 209.46 128.4696 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0438 Tc 10.3 0 0 10.3 219.27 130.8796 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0393 Tc 10.3 0 0 10.3 241.0957 130.8796 Tm (Sao)Tj 0 Tc 6.5001 0 0 6.5001 257.62 128.4696 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.3942 0 0 10.3 267.2 130.8796 Tm (in )Tj 0.0107 Tc 10.3 0 0 10.3 281.71 130.8796 Tm (the )Tj 0.0097 Tc -20.931 -1.076 Td (almitrine )Tj 0.0041 Tc 4.055 0 Td (bismesylate )Tj 0.04 Tc 5.087 0 Td (group )Tj -0.0037 Tc 2.885 0 Td (between )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.0263 0 0 10.3 227.96 119.7996 Tm (TO )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.3744 0 0 10.3 243.35 119.7996 Tm (and )Tj 10.3182 0 0 10.3 263.11 119.7996 Tm (T6 )Tj 0.0322 Tc 10.3 0 0 10.3 278.74 119.7996 Tm (and )Tj -0.0148 Tc -20.634 -1.051 Td (no )Tj 0.019 Tc 1.603 0 Td (further )Tj 0.0059 Tc 3.44 0 Td (increase )Tj 0.0041 Tc 3.89 0 Td (between )Tj 0.0053 Tc 3.965 0 Td (T6 )Tj 0.05 Tc 10.3744 0 0 10.3 216.38 108.9696 Tm (and )Tj 11.2988 0 0 10.3 238.06 108.9696 Tm (Tl2 )Tj -0.0328 Tc 10.3 0 0 10.3 261.15 108.9696 Tm (\(fig. )Tj -0.035 Tc 9.9738 0 0 10.3 284.28 108.9696 Tm (1\). )Tj 0.0264 Tc 10.3 0 0 10.3 65.87 97.8896 Tm (Compared )Tj 0.0436 Tc 4.941 0 Td (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.1778 0 0 10.3 131.16 97.8896 Tm (TO, )Tj EMC /Suspect <>BDC 0.05 Tc 10.6681 0 0 10.3 151.18 97.8896 Tm (Paco)Tj 0 Tc 6.8001 0 0 6.8001 173.82 95.4796 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.005 Tc 10.3 0 0 10.3 183.71 97.8896 Tm (values )Tj 0.0115 Tc 3.12 0 Td (showed )Tj 0.0341 Tc 3.706 0 Td (the )Tj 0.0024 Tc 1.859 0 Td (same )Tj -0.0041 Tc -20.13 -1.076 Td (slight )Tj 0.0443 Tc 2.704 0 Td (but )Tj -0.0006 Tc 1.879 0 Td (significant )Tj 0.0183 Tc 4.705 0 Td (improvement )Tj 0.05 Tc 10.7878 0 0 10.3 223.35 86.8096 Tm (at )Tj 0.0499 Tc 10.3 0 0 10.3 236.72 86.8096 Tm (both )Tj 0.0286 Tc 2.421 0 Td (T6 )Tj 0.0438 Tc 1.635 0 Td (and )Tj 0.0098 Tc 4 27.751 Td (T12 )Tj -0.0127 Tc 1.894 0 Td (in )Tj 0.0107 Tc 1.057 0 Td (the )Tj 0.0155 Tc 1.512 0 Td (almitrine )Tj 0.0017 Tc 4.01 0 Td (bismesylate )Tj 0.04 Tc 4.97 0 Td (group )Tj 0.0438 Tc 2.757 0 Td (and )Tj 0.032 Tc 1.809 0 Td (no )Tj 0.0133 Tc 1.301 0 Td (change )Tj 0.0107 Tc -19.31 -1.076 Td (in )Tj 0.0341 Tc 1.128 0 Td (the )Tj 0.0138 Tc 1.617 0 Td (placebo )Tj 0.04 Tc 3.519 0 Td (group )Tj -0.0227 Tc 2.826 0 Td (\(fig)Tj 0.341 0.341 0.329 rg 0 Tc 1.393 0 Td (. )Tj 0.149 0.149 0.137 rg -0.035 Tc 9.9738 0 0 10.3 433.82 361.5696 Tm (1\). )Tj 0.0383 Tc 10.3 0 0 10.3 329.57 350.4896 Tm (The )Tj 0.0126 Tc 2.103 0 Td (almitrine )Tj 0.0017 Tc 4.219 0 Td (bismesylate )Tj 0.0341 Tc 5.204 0 Td (group )Tj 0.0115 Tc 2.94 0 Td (showed )Tj 0 Tc 3.604 0 Td (a )Tj 0.0052 Tc 0.932 0 Td (slight )Tj 0.0059 Tc -19.96 -1.051 Td (increase )Tj 0.0107 Tc 3.6 0 Td (in )Tj 0.0176 Tc 1.106 0 Td (ventilation )Tj -0.035 Tc 10.2029 0 0 10.3 417.19 339.6596 Tm (\(fig. )Tj 10.1996 0 0 10.3 436.76 339.6596 Tm (2\) )Tj 0.05 Tc 10.3744 0 0 10.3 448.03 339.6596 Tm (and )Tj 0 Tc 10.3 0 0 10.3 467.29 339.6596 Tm (a )Tj 0.0146 Tc 0.768 0 Td (slight )Tj 0.0388 Tc 2.577 0 Td (drop )Tj 0.0107 Tc 2.245 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 10.3 0 0 10.3 536.1661 339.6596 Tm (0)Tj 6.2 0 0 6.2 544.42 337.4896 Tm (2 )Tj EMC ET BT 0.235 0.235 0.223 rg /T1_0 1 Tf 0.0438 Tc 10.3 0 0 10.3 319.68 328.5796 Tm (and )Tj ET BT /Suspect <>BDC 0.149 0.149 0.137 rg /T1_0 1 Tf 0.05 Tc 12.0966 0 0 10.3 344.7 328.5796 Tm (C0)Tj 0 Tc 6.5001 0 0 6.5001 359.72 326.4096 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0205 Tc 10.3 0 0 10.3 372.42 328.5796 Tm (arterial-end )Tj 0.0071 Tc 5.735 0 Td (tidal )Tj 0.0199 Tc 2.67 0 Td (pressure )Tj -0.008 Tc 4.314 0 Td (differences )Tj 0.0085 Tc -17.853 -1.076 Td (whereas )Tj 0.0101 Tc 3.599 0 Td (there )Tj 0.0013 Tc 2.316 0 Td (were )Tj 0.05 Tc 10.3527 0 0 10.3 403.09 317.4996 Tm (no )Tj -0.0006 Tc 10.3 0 0 10.3 416.92 317.4996 Tm (significant )Tj -0.0056 Tc 4.448 0 Td (differences )Tj -0.0127 Tc 4.653 0 Td (in )Tj 0.0205 Tc 1.026 0 Td (any )Tj 0.05 Tc 11.1664 0 0 10.3 539.53 317.4996 Tm (of )Tj -0.0039 Tc 10.3 0 0 10.3 320 306.6696 Tm (these )Tj 0.0487 Tc 2.378 0 Td (data )Tj 0.0119 Tc 2.138 0 Td (between )Tj 0.0196 Tc 3.731 0 Td (groups )Tj 0.0214 Tc 3.153 0 Td (\(table )Tj 0.0094 Tc 2.717 0 Td (II\). )Tj 0.0225 Tc -13.181 -1.076 Td (Although )Tj 0.0218 Tc 4.746 0 Td (there )Tj 0.0013 Tc 2.853 0 Td (were )Tj 0.032 Tc 2.712 0 Td (no )Tj 0.0184 Tc 1.834 0 Td (statistical )Tj -0.008 Tc 4.704 0 Td (differences )Tj 0.0041 Tc -17.804 -1.052 Td (between )Tj 0.0215 Tc 3.941 0 Td (groups, )Tj 0.0138 Tc 3.775 0 Td (placebo )Tj 0.0285 Tc 3.811 0 Td (patients )Tj 0.0068 Tc 3.935 0 Td (showed )Tj -0.0004 Tc 3.717 0 Td (slightly )Tj 0.0058 Tc -19.213 -1.098 Td (decreased )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.3398 0 0 10.3 365.49 273.4396 Tm (Ppa )Tj EMC ET BT /T1_0 1 Tf 10.3744 0 0 10.3 386.62 273.4396 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0321 Tc 10.3 0 0 10.3 407.63 273.4396 Tm (Ppa/Qc )Tj EMC ET BT 0.235 0.235 0.223 rg /T1_0 1 Tf 0.0004 Tc 10.3 0 0 10.3 444.2568 273.4396 Tm (values )Tj 0.149 0.149 0.137 rg 0.0168 Tc 3.029 0 Td (\(table )Tj 0.0403 Tc 2.787 0 Td (II, )Tj 0.235 0.235 0.223 rg -0.035 Tc 9.7759 0 0 10.3 519.3 273.4396 Tm (fig)Tj 0.341 0.341 0.329 rg 0 Tc 10.3 0 0 10.3 530.27 273.4396 Tm (. )Tj 0.149 0.149 0.137 rg -0.0321 Tc 0.687 0 Td (3\). )Tj 0.0122 Tc -21.148 -1.052 Td (Almitrine )Tj 0.0041 Tc 4.491 0 Td (bismesylate )Tj 0.0192 Tc 5.281 0 Td (treated )Tj 0.0218 Tc 3.323 0 Td (patients )Tj 0.0021 Tc 3.772 0 Td (showed )Tj 0.235 0.235 0.223 rg -0.0135 Tc 3.566 0 Td (very )Tj 0.149 0.149 0.137 rg 0.0162 Tc -20.446 -1.052 Td (stable )Tj 0.0208 Tc 3.098 0 Td (mean )Tj 0.0215 Tc 2.9 0 Td (haemodynamic )Tj 0.05 Tc 10.4117 0 0 10.3 453.33 251.7596 Tm (data )Tj 0.0349 Tc 10.3 0 0 10.3 479.41 251.7596 Tm (throughout )Tj 0.0107 Tc 5.401 0 Td (the )Tj 0.0128 Tc -20.936 -1.075 Td (study. )Tj 0.0163 Tc 2.88 0 Td (Considering )Tj 0.0224 Tc 5.384 0 Td (the )Tj 0.005 Tc 1.641 0 Td (previously )Tj 0.0118 Tc 4.594 0 Td (observed )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0228 Tc 10.3 0 0 10.3 510.4027 240.6871 Tm (0.53 )Tj EMC /Suspect <>BDC 0.0458 Tc 2.065 0 Td (kPa )Tj EMC ET BT /T1_0 1 Tf 0 Tc 10.3 0 0 10.3 319.4201 229.8515 Tm [(\( )271(4 )]TJ 0.0246 Tc 10.3 0 0 10.3 479.41 251.7596 Tm -14.471 -2.127 Td (mmHg\) )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.4918 0 0 10.3 366.45 229.8496 Tm (Ppa )Tj EMC ET BT /T1_0 1 Tf 0.0146 Tc 10.3 0 0 10.3 385.99 229.8496 Tm (modification )Tj 0.0248 Tc 5.555 0 Td (after )Tj 0.0001 Tc 2.217 0 Td (single )Tj 0.0191 Tc 2.67 0 Td (oral )Tj 0.0022 Tc 1.893 0 Td (doses )Tj 0.05 Tc 10.8872 0 0 10.3 539.29 229.8496 Tm (of )Tj 0.0185 Tc 10.3 0 0 10.3 319.2 218.7696 Tm (almitrine )Tj 0.0087 Tc 3.962 0 Td (bismesylate )Tj -0.0327 Tc 5.001 0 Td ([15, )Tj -0.035 Tc 10.0672 0 0 10.3 429.53 218.7696 Tm (27], )Tj 10.2693 0 0 10.3 446.67 218.7696 Tm (we )Tj 0.0203 Tc 10.3 0 0 10.3 460.55 218.7696 Tm (calculated )Tj 0.0224 Tc 4.426 0 Td (the )Tj 0.0148 Tc 1.5 0 Td (power )Tj 0.05 Tc 11.1664 0 0 10.3 319.2 207.6996 Tm (of )Tj 0.0224 Tc 10.3 0 0 10.3 333.73 207.6996 Tm (the )Tj 0.0137 Tc 1.812 0 Td (statistical )Tj 0.0066 Tc 4.453 0 Td (test. )Tj 0.0266 Tc 2.239 0 Td (The )Tj 0.0207 Tc 2.137 0 Td (power )Tj 0.05 Tc 11.4455 0 0 10.3 475.47 207.6996 Tm (of )Tj 0.0224 Tc 10.3 0 0 10.3 490.01 207.6996 Tm (the )Tj 0.0142 Tc 1.8 0 Td (test )Tj -0.0026 Tc 1.966 0 Td (used )Tj 0.0236 Tc -20.373 -1.076 Td (comparing )Tj 0.0224 Tc 4.73 0 Td (the )Tj 0.0232 Tc 1.566 0 Td (two )Tj 0.0243 Tc 1.818 0 Td (groups )Tj 0.05 Tc 11.1664 0 0 10.3 434.54 196.6196 Tm (of )Tj 0.235 0.235 0.223 rg -0.0072 Tc 10.3 0 0 10.3 446.06 196.6196 Tm (seven )Tj 0.149 0.149 0.137 rg 0.05 Tc 10.3744 0 0 10.3 471.87 196.6196 Tm (and )Tj 0.0025 Tc 10.3 0 0 10.3 490.89 196.6196 Tm (eight )Tj 0.0185 Tc 2.28 0 Td (patients )Tj -0.015 Tc -18.94 -1.052 Td (was )Tj 0.0021 Tc 1.893 0 Td (very )Tj 0.0142 Tc 2.116 0 Td (satisfactory; )Tj 0.0224 Tc 5.435 0 Td (the )Tj 0.0054 Tc 1.658 0 Td (Beta )Tj 0.0175 Tc 2.19 0 Td (\(type )Tj 0.0222 Tc 2.483 0 Td (II\) )Tj 0.0338 Tc 1.399 0 Td (error )Tj 0.05 Tc 11.1664 0 0 10.3 520.99 185.7796 Tm (of )Tj 10.5178 0 0 10.3 533.36 185.7796 Tm (not )Tj 0.0083 Tc 10.3 0 0 10.3 319.21 174.7096 Tm (detecting )Tj 0 Tc 4.137 0 Td (a )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.3 0 0 10.3 370.9675 174.7096 Tm (0)Tj 0.341 0.341 0.329 rg 0.527 0 Td (.)Tj 0.149 0.149 0.137 rg -0.035 Tc 9.8308 0 0 10.3 379.37 174.7096 Tm (53 )Tj EMC /Suspect <>BDC 0.0458 Tc 10.3 0 0 10.3 393.45 174.7096 Tm (kPa )Tj EMC ET BT /T1_0 1 Tf -0.0192 Tc 10.3 0 0 10.3 414.5444 174.7096 Tm (\(4 )Tj 0.0129 Tc 1.225 0 Td (mmHg\) )Tj -0.0046 Tc 3.593 0 Td (difference )Tj -0.0033 Tc 4.45 0 Td (was )Tj 0.0443 Tc 1.948 0 Td (8%. )Tj 0.0135 Tc -20.494 -1.052 Td (This )Tj 0.0145 Tc 2.321 0 Td (result )Tj 0.0236 Tc 2.735 0 Td (means )Tj 0.0314 Tc 3.179 0 Td (that, )Tj 0.0054 Tc 2.401 0 Td (despite )Tj 0.0107 Tc 3.397 0 Td (the )Tj -0.0032 Tc 1.754 0 Td (relatively )Tj 0.0033 Tc 4.243 0 Td (small )Tj 0.0306 Tc -20.023 -1.076 Td (number )Tj 0.05 Tc 10.8872 0 0 10.3 358.45 152.7896 Tm (of )Tj 0.0229 Tc 10.3 0 0 10.3 373.26 152.7896 Tm (patients, )Tj 0.0101 Tc 4.204 0 Td (there )Tj 0.0084 Tc 2.643 0 Td (was )Tj 0 Tc 2.189 0 Td (a )Tj 0.0311 Tc 1.074 0 Td (92% )Tj 0.0154 Tc 2.527 0 Td (chance )Tj 0.05 Tc 10.8872 0 0 10.3 539.05 152.7896 Tm (of )Tj 0.0141 Tc 10.3 0 0 10.3 318.97 141.7196 Tm (detecting )Tj 0 Tc 4.067 0 Td (a )Tj -0.0046 Tc 0.795 0 Td (difference )Tj 0.0002 Tc 4.383 0 Td (between )Tj 0.0224 Tc 3.667 0 Td (the )Tj 0.0115 Tc 1.614 0 Td (two )Tj 0.0137 Tc 1.864 0 Td (groups, )Tj 0.235 0.235 0.223 rg 0.05 Tc 10.4705 0 0 10.3 523.16 141.7196 Tm (at )Tj 0.149 0.149 0.137 rg 0.0224 Tc 10.3 0 0 10.3 534.56 141.7196 Tm (the )Tj -0.007 Tc -20.936 -1.052 Td (significance )Tj -0.0136 Tc 5.219 0 Td (level )Tj 0.05 Tc 11.1664 0 0 10.3 396.98 130.8796 Tm (of )Tj 0 Tc 10.3 0 0 10.3 410.82 130.8796 Tm (p )Tj 0.235 0.235 0.223 rg /T1_1 1 Tf 10.5 0 0 10.5 417.63 130.8796 Tm (< )Tj ET BT /Suspect <>BDC 0.149 0.149 0.137 rg /T1_0 1 Tf -0.0095 Tc 10.3 0 0 10.3 426.11 130.8796 Tm (0.05, )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.8462 0 0 10.3 451.41 130.8796 Tm (if )Tj 0.0322 Tc 10.3 0 0 10.3 462.24 130.8796 Tm (any )Tj 0.0134 Tc 1.983 0 Td (such )Tj -0.0072 Tc 2.319 0 Td (difference )Tj -0.0006 Tc -18.237 -1.076 Td (existed)Tj 0.341 0.341 0.329 rg 0 Tc 2.913 0 Td (. )Tj 0.149 0.149 0.137 rg 0.0163 Tc -1.93 -1.051 Td (Considering )Tj 0.0107 Tc 5.572 0 Td (the )Tj 0.0247 Tc 1.748 0 Td (importance )Tj 0.05 Tc 11.1664 0 0 10.3 458.14 108.9696 Tm (of )Tj 0.0112 Tc 10.3 0 0 10.3 471.88 108.9696 Tm (detecting )Tj 0.0141 Tc 4.239 0 Td (haemo\255)Tj 0.0165 Tc -19.108 -1.076 Td (dynamic )Tj 0.0188 Tc 4.028 0 Td (variations, )Tj 0.0089 Tc 4.926 0 Td (individual )Tj 0.05 Tc 10.4117 0 0 10.3 458.87 97.8896 Tm (data )Tj 0.0013 Tc 10.3 0 0 10.3 483.04 97.8896 Tm (were )Tj 0.235 0.235 0.223 rg 0.0038 Tc 2.422 0 Td (analysed. )Tj 0.149 0.149 0.137 rg 0.0105 Tc -18.368 -1.051 Td (Again )Tj -0.035 Tc 10.2693 0 0 10.3 347.95 87.0596 Tm (we )Tj 0.009 Tc 10.3 0 0 10.3 362.55 87.0596 Tm (chose )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0072 Tc 10.3 0 0 10.3 389.7523 87.0596 Tm (0.53 )Tj EMC /Suspect <>BDC 0.0341 Tc 2.089 0 Td (kPa )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.8906 0 0 10.3 431.16 87.0596 Tm (\(4 )Tj 0.0129 Tc 10.3 0 0 10.3 442.57 87.0596 Tm (mmHg\) )Tj 0.0207 Tc 3.522 0 Td (as )Tj 0.0107 Tc 1.2 0 Td (the )Tj 0.0147 Tc 1.59 0 Td (threshold )Tj ET endstream endobj 19 0 obj <>/Filter/JBIG2Decode/Height 3505/ImageMask true/Length 16686/Name/X/Subtype/Image/Type/XObject/Width 2480>>stream #x, . -XGTbYVZa9eCx.CRt9F~a*&!{ 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0.286 0.286 0.275 rg 0.197 0 Td (. )Tj ET BT /Suspect <>BDC 0.376 0.376 0.365 rg /T1_0 1 Tf -0.035 Tc 9.4235 0 0 12.2 413.74 689.5396 Tm (.l. )Tj EMC ET BT 0.565 0.565 0.553 rg /T1_0 1 Tf 7.9813 0 0 12.2 421 689.5396 Tm (..)Tj 0.714 0.714 0.706 rg 8.5514 0 0 12.2 425.08 689.5396 Tm (..)Tj 0.565 0.565 0.553 rg 8.3115 0 0 12.2 429.42 689.5396 Tm (... )Tj ET BT /Suspect <>BDC 0.286 0.286 0.275 rg /T1_0 1 Tf 9.0252 0 0 17.2001 435.43 689.5396 Tm (.r. )Tj EMC ET BT 0.565 0.565 0.553 rg /T1_0 1 Tf 8.6893 0 0 17.2001 442.66 689.5396 Tm (...)Tj 0.376 0.376 0.365 rg 0 Tc 17.2001 0 0 17.2001 448.74 689.5396 Tm (. )Tj ET BT /Suspect <>BDC 0.565 0.565 0.553 rg /T1_0 1 Tf -0.035 Tc 9.0401 0 0 17.2001 450.84 689.5396 Tm (\267\267\267\267 )Tj EMC ET BT /T1_0 1 Tf 9.7644 0 0 17.2001 462.38 689.5396 Tm (...... )Tj 7.9813 0 0 17.2001 475.9 689.5396 Tm (.. )Tj 0.161 0.161 0.149 rg /T1_2 1 Tf 0 Tc 9.2 0 0 9.2 316.69 672.9296 Tm (s )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.05 Tc 6.5697 0 0 6.2 304.07 665.9496 Tm (35)Tj 0.565 0.565 0.553 rg 0 Tc 6.2 0 0 6.2 311.14 665.9496 Tm (, )Tj EMC ET BT 0.161 0.161 0.149 rg /T1_4 1 Tf -0.035 Tc 5.2767 0 0 5.8001 256.06 625.9696 Tm (/\(J )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0 Tc 5.9001 0 0 5.9001 275.69 625.9696 Tm (t)Tj 0.376 0.376 0.365 rg 0.05 Tc 7.3365 0 0 5.9001 278.71 625.9696 Tm (l2 )Tj EMC /Suspect <>BDC 0.161 0.161 0.149 rg /T1_0 1 Tf 7.4766 0 0 7.1 260.78 617.5396 Tm (months )Tj EMC ET BT /T1_3 1 Tf 5.7405 0 0 5.6 290.82 596.8296 Tm (almitrine )Tj 0 Tc 5.6 0 0 5.6 256.64 586.9596 Tm [(o )150(.)]TJ 0.286 0.286 0.275 rg 0.0421 Tc 0.857 0 Td (..)Tj 0.161 0.161 0.149 rg 0 Tc 0.559 0 Td (.)Tj 0.376 0.376 0.365 rg -0.0009 Tc 0.345 0 Td (.. )Tj 0.161 0.161 0.149 rg 0 Tc 0.561 0 Td (o )Tj 0.376 0.376 0.365 rg 0.557 0 Td (.)Tj 0.565 0.565 0.553 rg 0.259 0 Td (.)Tj 0.376 0.376 0.365 rg 0.0421 Tc 0.3 0 Td (..)Tj 0.161 0.161 0.149 rg 0 Tc 0.602 0 Td (.)Tj 0.714 0.714 0.706 rg -0.035 Tc 4.9379 0 0 5.6 281.2 586.9596 Tm (.. )Tj 0.161 0.161 0.149 rg 0 Tc 5.6 0 0 5.6 283.61 586.9596 Tm (o )Tj ET BT /Suspect <>BDC /T1_3 1 Tf 0.05 Tc 5.755 0 0 5.6 291.1 586.9596 Tm (placebo )Tj EMC ET BT /T1_0 1 Tf 0.0003 Tc 8.3 0 0 8.3 46.44 565.2896 Tm (Fig. )Tj /T1_1 1 Tf 0.05 Tc 8.7701 0 0 7.8001 62.61 565.2896 Tm (I. )Tj /T1_0 1 Tf 0.0091 Tc 8.3 0 0 8.3 75.78 565.2896 Tm (Time )Tj 0.022 Tc (course )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.0124 0 0 8.3 120.56 565.2896 Tm (ofPao)Tj 0 Tc 5.2 0 0 5.2 143.49 563.5996 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.331 0 0 8.3 148.73 565.2896 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.4649 0 0 8.3 164.19 565.2896 Tm (Paco)Tj 0 Tc 5.2 0 0 5.2 182.26 563.5996 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0225 Tc 8.3 0 0 8.3 187.76 565.2896 Tm (in )Tj 0.0078 Tc 1.1 0 Td (almitrine )Tj -0.0128 Tc 3.987 0 Td (bismesyl)Tj 0.286 0.286 0.275 rg 0 Tc 3.47 0 Td (a)Tj 0.161 0.161 0.149 rg 0.0077 Tc 0.501 0 Td (te )Tj ET BT /Suspect <>BDC /T1_3 1 Tf 0.05 Tc 15.205 0 0 12 271.45 565.2896 Tm (\(e-e-e\) )Tj EMC ET BT 0.286 0.286 0.275 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 318.98 565.2896 Tm (a)Tj 0.161 0.161 0.149 rg 0.0477 Tc 0.502 0 Td (nd )Tj 0.0183 Tc 1.366 0 Td (pla)Tj 0.286 0.286 0.275 rg -0.0246 Tc 1.265 0 Td (ce)Tj 0.161 0.161 0.149 rg 0.025 Tc 0.882 0 Td (bo )Tj 0.05 Tc 11.147 0 0 8.3 363.24 565.2896 Tm (\(0 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 376.44 565.2896 Tm (\267 )Tj EMC /Suspect <>BDC 0.376 0.376 0.365 rg 0.465 0 Td (\267 )Tj EMC /Suspect <>BDC 0.286 0.286 0.275 rg 0.493 0 Td (\267 )Tj EMC /Suspect <>BDC 0.376 0.376 0.365 rg 0.493 0 Td (\267 )Tj EMC /Suspect <>BDC 0.286 0.286 0.275 rg 0.62 0 Td (0 )Tj EMC /Suspect <>BDC 0.161 0.161 0.149 rg 1.149 0 Td (\267 )Tj EMC /Suspect <>BDC 0.494 0 Td (\267 )Tj EMC /Suspect <>BDC 0.376 0.376 0.365 rg 0.493 0 Td (\267 )Tj EMC /Suspect <>BDC 0.714 0.714 0.706 rg 0.522 0 Td (\267 )Tj EMC /Suspect <>BDC 0.376 0.376 0.365 rg 0.592 0 Td (0)Tj 0.161 0.161 0.149 rg 0.845 0 Td (\) )Tj EMC ET BT /T1_0 1 Tf 0.0148 Tc 8.3 0 0 8.3 432.4152 565.2896 Tm (groups. )Tj 0.0296 Tc 3.395 0 Td (The )Tj 0.0154 Tc 1.924 0 Td (betwe)Tj 0.286 0.286 0.275 rg 0 Tc 2.425 0 Td (e)Tj 0.161 0.161 0.149 rg 0.473 0 Td (n )Tj 0.0369 Tc 0.776 0 Td (group )Tj -0.0022 Tc -55.531 -1.073 Td (analysis )Tj 0.0093 Tc 3.477 0 Td (showed )Tj 0 Tc (a )Tj 0.0016 Tc 4.092 0 Td (significant )Tj -0.0071 Tc 4.443 0 Td (difference )Tj 0.0167 Tc 4.292 0 Td (for )Tj 0.05 Tc 8.3631 0 0 8.3 193.81 556.3796 Tm (Pao)Tj 0 Tc 5.2 0 0 5.2 207.3 554.6896 Tm (2)Tj 0.685 0.325 Td (, )Tj -0.0074 Tc 8.3 0 0 8.3 215.03 556.3796 Tm (which )Tj -0.003 Tc 2.655 0 Td (significantly )Tj 0.0147 Tc 5.229 0 Td (improved )Tj 0.05 Tc 8.8841 0 0 8.3 315.12 556.3796 Tm (at )Tj 0.0379 Tc 8.3 0 0 8.3 324.05 556.3796 Tm (T6 )Tj 0.05 Tc 8.4882 0 0 8.3 335.59 556.3796 Tm (and )Tj 8.5182 0 0 8.3 351.02 556.3796 Tm (TI2 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0273 Tc 8.3 0 0 8.3 366.4 556.3796 Tm (\(p)Tj 0.286 0.286 0.275 rg 0 Tc 1.023 0 Td (<)Tj 0.161 0.161 0.149 rg -0.035 Tc 7.5602 0 0 8.3 381.36 556.3796 Tm (O.OI\) )Tj EMC ET BT /T1_0 1 Tf 0.0067 Tc 8.3 0 0 8.3 400.68 556.3796 Tm (within )Tj -0.0141 Tc 2.93 0 Td (the )Tj 0.0151 Tc 1.471 0 Td (almitrine )Tj 0.05 Tc 8.3191 0 0 8.3 470.22 556.3796 Tm (group )Tj 0.0204 Tc 8.3 0 0 8.3 493.32 556.3796 Tm (compared )Tj 0.0377 Tc -53.869 -1.045 Td (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.3339 0 0 8.3 55.8 547.7096 Tm (TO )Tj EMC ET BT /T1_0 1 Tf 0.0481 Tc 8.3 0 0 8.3 68.16 547.7096 Tm (but )Tj 0.05 Tc 8.4142 0 0 8.3 82.34 547.7096 Tm (not )Tj 0.0225 Tc 8.3 0 0 8.3 96.49 547.7096 Tm (in )Tj 0.0294 Tc 1.166 0 Td (the )Tj 0.0061 Tc 1.6 0 Td (placebo )Tj 0.0202 Tc 3.501 0 Td (group. )Tj 0 Tc 3.082 0 Td (A )Tj 0.0016 Tc 1.06 0 Td (significant )Tj -0.0104 Tc 4.56 0 Td (difference )Tj 0.0086 Tc 4.301 0 Td (was )Tj 0.0056 Tc 1.907 0 Td (observed )Tj 0.0358 Tc 4.004 0 Td (on )Tj 0.0284 Tc 1.392 0 Td (entry )Tj 0.0167 Tc 2.524 0 Td (for )Tj 0.0004 Tc 1.575 0 Td (the )Tj 0.006 Tc 1.596 0 Td (two )Tj 0.0156 Tc 1.88 0 Td (groups )Tj 0.0312 Tc 3.159 0 Td (for )Tj 0.05 Tc 8.349 0 0 8.3 419.44 547.7096 Tm (Paco)Tj 0 Tc 5.2 0 0 5.2 437.03 545.7796 Tm (2)Tj 0.685 0.371 Td (, )Tj 0.0139 Tc 8.3 0 0 8.3 445.47 547.7096 Tm (therefore )Tj 0.0174 Tc 4.119 0 Td (they )Tj -0.0072 Tc 2.09 0 Td (were )Tj 0.05 Tc 8.5895 0 0 8.3 515.79 547.7096 Tm (not )Tj 0.012 Tc 8.3 0 0 8.3 45.91 538.7996 Tm (compared. )Tj 0.02 Tc 4.589 0 Td (However )Tj 0.0149 Tc 4.035 0 Td (the )Tj 0.014 Tc (one )Tj -0.0034 Tc 3.28 0 Td (way )Tj 0.0061 Tc 1.906 0 Td (analysis )Tj 0.05 Tc 9.4914 0 0 8.3 189.66 538.7996 Tm (of )Tj 0.0067 Tc 8.3 0 0 8.3 199.13 538.7996 Tm (variance )Tj 0.0093 Tc 3.701 0 Td (showed )Tj 0 Tc (a )Tj -0.0013 Tc 4.119 0 Td (significant )Tj 0.0035 Tc 4.445 0 Td (decrease )Tj 0.05 Tc 9.2123 0 0 8.3 331.98 538.7996 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.4649 0 0 8.3 341.66 538.7996 Tm (Paco)Tj 0 Tc 5.2 0 0 5.2 359.49 536.8696 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.8841 0 0 8.3 364.73 538.7996 Tm (at )Tj 0.0089 Tc 8.3 0 0 8.3 373.66 538.7996 Tm (T6 )Tj 0.0383 Tc 1.419 0 Td (and )Tj 0.05 Tc 9.3338 0 0 8.3 400.13 538.7996 Tm (Tl2 )Tj -0.0018 Tc 8.3 0 0 8.3 416.25 538.7996 Tm (\(p )Tj 0 Tc 0.994 0 Td (< )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 7.8001 0 0 7.8001 431.2 538.7996 Tm (0)Tj 0.286 0.286 0.275 rg 0.545 0 Td (.)Tj 0.161 0.161 0.149 rg 0.0081 Tc 0.227 0 Td (05\) )Tj EMC ET BT /T1_0 1 Tf 0.0328 Tc 8.3 0 0 8.3 449.98 538.7996 Tm (compared )Tj 0.0377 Tc 4.475 0 Td (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 6.9578 0 0 8.3 496.48 538.7996 Tm (TO )Tj EMC ET BT /T1_0 1 Tf 0.0225 Tc 8.3 0 0 8.3 507.78 538.7996 Tm (in )Tj 0.0004 Tc 1.137 0 Td (the )Tj 0.0078 Tc -56.784 -1.073 Td (almitrine )Tj 0.0202 Tc 4.005 0 Td (group, )Tj 0.05 Tc 8.4142 0 0 8.3 104.5 529.8896 Tm (not )Tj 0.0225 Tc 8.3 0 0 8.3 118.65 529.8896 Tm (in )Tj 0.0149 Tc 1.137 0 Td (the )Tj 0.0109 Tc 1.57 0 Td (placebo )Tj 0.0202 Tc 3.501 0 Td (group. )Tj -0.035 Tc 8.7709 0 0 11.8 71.26 500.5096 Tm (VE )Tj /T1_1 1 Tf 0.05 Tc 9.6764 0 0 9.1 64.33 487.9896 Tm (L/mn )Tj /T1_2 1 Tf -0.035 Tc 8.4176 0 0 9.5 71.13 477.3996 Tm (11.5 )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 8.2151 0 0 8.9 75.34 456.4496 Tm (71 )Tj EMC /Suspect <>BDC /T1_4 1 Tf -0.0037 Tc 8 0 0 8 69 435.0196 Tm (10.5 )Tj EMC /Suspect <>BDC 0.05 Tc 8.8009 0 0 8 72.58 413.0996 Tm (10 )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 8.7913 0 0 13.8 217.21 417.1996 Tm (..)Tj 0.376 0.376 0.365 rg 0 Tc 13.8 0 0 13.8 222.85 417.1996 Tm (.)Tj 0.161 0.161 0.149 rg -0.035 Tc 9.8683 0 0 13.8 225.85 417.1996 Tm (...)Tj 0.286 0.286 0.275 rg 0 Tc 13.8 0 0 13.8 234.17 417.1996 Tm (. )Tj ET BT /Suspect <>BDC 0.161 0.161 0.149 rg /T1_1 1 Tf 38.8 0 0 38.8 236.95 417.1996 Tm (/ )Tj EMC ET BT 0 g /T1_1 1 Tf 11 0 0 11 202.94 407.7996 Tm (.)Tj 0.161 0.161 0.149 rg 0.263 0 Td (. )Tj ET BT /Suspect <>BDC 0.09 0.094 0.082 rg /T1_1 1 Tf -0.035 Tc 9.8683 0 0 13.8 208.75 407.7996 Tm (\267\267\267 )Tj EMC ET BT 0.161 0.161 0.149 rg /T1_4 1 Tf -0.0215 Tc 8 0 0 8 72.57 392.8696 Tm (9.5 )Tj 0 Tc 0.631 -2.679 Td (9 )Tj /T1_0 1 Tf 0.05 Tc 12.8612 0 0 11 107.61 337.9696 Tm (ta )Tj 8.7993 0 0 8.4 200.74 305.9496 Tm (aJmitrine )Tj 0 Tc 8.3 0 0 8.3 152.11 293.1796 Tm (o )Tj 0.029 Tc 0.655 0 Td (.... )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0111 Tc 8.3 0 0 8.3 167.1828 293.1796 Tm (\267o )Tj EMC ET BT /T1_0 1 Tf 0.0335 Tc 8.3 0 0 8.3 174.1631 293.1796 Tm (...... )Tj 0 Tc 1.665 0 Td (o )Tj 0.05 Tc 8.7191 0 0 8.3 200.84 293.1796 Tm (placebo )Tj 0.0003 Tc 8.3 0 0 8.3 44.27 279.2196 Tm (Fig. )Tj -0.035 Tc 7.9565 0 0 8.3 59.91 279.2196 Tm (2. )Tj -0.0006 Tc 8.3 0 0 8.3 73.86 279.2196 Tm (Time )Tj 0.022 Tc 2.871 0 Td (course )Tj 0.05 Tc 8.9331 0 0 8.3 126.58 279.2196 Tm (of )Tj 0.0144 Tc 8.3 0 0 8.3 139.89 279.2196 Tm (ventilation )Tj 0.0225 Tc 5.187 0 Td (in )Tj 0.0115 Tc 1.594 0 Td (almitrine )Tj 0.0053 Tc 4.48 0 Td (bismesylate )Tj 0 Tc -22.817 -1.161 Td (\( )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 18.2663 0 0 8.3 47.38 269.5796 Tm (\225-\225-\225\) )Tj EMC ET BT /T1_0 1 Tf 8.331 0 0 8.3 90.94 269.5796 Tm (and )Tj 0.0109 Tc 8.3 0 0 8.3 105.73 269.5796 Tm (placebo )Tj 0 Tc 3.41 0 Td (\( )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.3 0 0 8.3 137.6518 269.5796 Tm (0 )Tj EMC /Suspect <>BDC 1.035 0 Td (\267 )Tj EMC /Suspect <>BDC 0.435 0 Td (\267 )Tj EMC /Suspect <>BDC 0.09 0.094 0.082 rg 0.435 0 Td (\267 )Tj EMC /Suspect <>BDC 0.161 0.161 0.149 rg 0.435 0 Td (\267 )Tj EMC /Suspect <>BDC 0.533 0 Td (0 )Tj EMC /Suspect <>BDC 1.093 0 Td (\267 )Tj EMC /Suspect <>BDC 0.435 0 Td (\267 )Tj EMC /Suspect <>BDC 0.406 0 Td (\267 )Tj EMC /Suspect <>BDC 0.435 0 Td (\267 )Tj EMC /Suspect <>BDC 0.05 Tc 11.4615 0 0 8.3 185.54 269.5796 Tm (0\) )Tj EMC ET BT /T1_0 1 Tf 0.01 Tc 8.3 0 0 8.3 197.39 269.5796 Tm (groups. )Tj 0.05 Tc 8.3293 0 0 8.3 224.95 269.5796 Tm (No )Tj -0.0151 Tc 8.3 0 0 8.3 237.56 269.5796 Tm (signifi)Tj 0.286 0.286 0.275 rg 0 Tc 2.441 0 Td (c)Tj 0.161 0.161 0.149 rg 0.05 Tc 8.4625 0 0 8.3 261.43 269.5796 Tm (ant )Tj 0.0086 Tc 8.3 0 0 8.3 43.75 261.1596 Tm (changes )Tj -0.0072 Tc 3.547 0 Td (were )Tj 0.0097 Tc 2.255 0 Td (observed )Tj 0.0194 Tc 4.004 0 Td (during )Tj 0.0294 Tc 3.024 0 Td (the )Tj 0.0093 Tc 1.613 0 Td (study. )Tj 0.0269 Tc 10.3 0 0 10.3 43.71 239.2396 Tm (for )Tj 0.0115 Tc 2.037 0 Td (individual )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.3398 0 0 10.3 116.02 239.2396 Tm (Ppa )Tj EMC ET BT /T1_0 1 Tf 0.0142 Tc 10.3 0 0 10.3 140.85 239.2396 Tm (variations. )Tj 0.0467 Tc 5.255 0 Td (In )Tj 0.0107 Tc 1.711 0 Td (the )Tj 0.0257 Tc 2.074 0 Td (almitr)Tj 0.286 0.286 0.275 rg 0 Tc 2.526 0 Td (i)Tj 0.161 0.161 0.149 rg -0.0045 Tc 0.287 0 Td (ne )Tj -0.0006 Tc -21.272 -1.075 Td (bismesylate )Tj 0.0241 Tc 5.32 0 Td (group, )Tj 0.0149 Tc 3.341 0 Td (four )Tj 0.0285 Tc 2.35 0 Td (patients )Tj -0.0143 Tc 3.901 0 Td (were )Tj 0.0108 Tc 2.513 0 Td (stable, )Tj 0.0251 Tc 3.278 0 Td (one )Tj 0.0021 Tc -20.718 -1.076 Td (showed )Tj 0 Tc 3.371 0 Td (a )Tj 0.0079 Tc 0.772 0 Td (decrease )Tj 0.034 Tc 3.788 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.03 Tc 10.3 0 0 10.3 136.73 217.0843 Tm (Ppa, )Tj EMC ET BT /T1_0 1 Tf 0.0438 Tc 10.3 0 0 10.3 159.0707 217.0843 Tm (and )Tj 0.0218 Tc 1.878 0 Td (three )Tj 0 Tc 2.4 0 Td (a )Tj -0.0092 Tc 0.768 0 Td (single )Tj 0.0093 Tc 2.624 0 Td (increase )Tj 0.05 Tc 10.4705 0 0 10.3 43.72 206.2496 Tm (at )Tj 0.0134 Tc 10.3 0 0 10.3 57.45 206.2496 Tm (one )Tj 0.0231 Tc 1.986 0 Td (evaluation )Tj 0.0017 Tc 4.917 0 Td (time )Tj 0.0214 Tc 2.306 0 Td (\(table )Tj 0.029 Tc 2.904 0 Td (III\). )Tj 0.05 Tc 10.5385 0 0 10.3 205.81 206.2496 Tm (In )Tj 0.0224 Tc 10.3 0 0 10.3 220.55 206.2496 Tm (the )Tj 0.0177 Tc 1.804 0 Td (placebo )Tj 0.0194 Tc -18.993 -1.075 Td (group, )Tj -0.035 Tc 10.0116 0 0 10.3 75.98 195.1796 Tm (five )Tj 0.0252 Tc 10.3 0 0 10.3 95.86 195.1796 Tm (patients )Tj -0.0221 Tc 3.76 0 Td (were )Tj 0.0162 Tc 2.372 0 Td (stable )Tj 0.0438 Tc 2.88 0 Td (and )Tj -0.0119 Tc 2.065 0 Td (two )Tj 0.0115 Tc 1.976 0 Td (showed )Tj 0 Tc 3.605 0 Td (a )Tj 0.0012 Tc -21.765 -1.052 Td (decrease )Tj 0.0107 Tc 3.788 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.4918 0 0 10.3 93.87 184.3396 Tm (Ppa )Tj EMC ET BT /T1_0 1 Tf 0.0168 Tc 10.3 0 0 10.3 114.02 184.3396 Tm (\(table )Tj 0.0115 Tc 2.693 0 Td (III\). )Tj /T1_3 1 Tf 0.0229 Tc 9.4 0 0 9.4 135.3 156.6496 Tm (Discussion )Tj /T1_0 1 Tf 0.0135 Tc 10.3 0 0 10.3 52.89 140.2696 Tm (This )Tj 0.0251 Tc 2.056 0 Td (one )Tj 0.0282 Tc 1.738 0 Td (year )Tj 0.0259 Tc 2.045 0 Td (study )Tj 0.0107 Tc 2.508 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.3984 0 0 10.3 149.43 140.2696 Tm (COLD )Tj EMC ET BT /T1_0 1 Tf 0.0285 Tc 10.3 0 0 10.3 182.06 140.2696 Tm (patients )Tj 0.0173 Tc 3.527 0 Td (with )Tj 0.0261 Tc 2.073 0 Td (chronic )Tj 0.0134 Tc -19.092 -1.051 Td (hypoxia )Tj 0.0068 Tc 3.705 0 Td (showed )Tj 0.0473 Tc 3.518 0 Td (that )Tj 0.0155 Tc 2.073 0 Td (almitrine )Tj 0.0041 Tc 4.15 0 Td (bismesylate )Tj 0.0131 Tc 5.155 0 Td (adminis\255)Tj 0.0101 Tc -18.602 -1.076 Td (tered )Tj 0.0057 Tc 2.587 0 Td (orally )Tj 0.0132 Tc 2.901 0 Td (induced )Tj 0.0008 Tc 3.762 0 Td (clinical )Tj 0.0207 Tc 3.461 0 Td (improvement )Tj 0.0237 Tc 6.061 0 Td (together )Tj 0.0173 Tc -18.818 -1.076 Td (with )Tj 0 Tc 2.212 0 Td (a )Tj 0.0286 Tc 0.827 0 Td (mean )Tj 0.0093 Tc 2.635 0 Td (increase )Tj 0.0107 Tc 3.694 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.4918 0 0 10.3 151.18 107.2796 Tm (Pao)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 168.27 105.1196 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 11.4455 0 0 10.3 176.16 107.2796 Tm (of )Tj -0.0282 Tc 10.3 0 0 10.3 189.88 107.2796 Tm (1.2 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0458 Tc 10.3 0 0 10.3 205.8656 107.2796 Tm (kPa )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.1996 0 0 10.3 226.23 107.2796 Tm (\(9 )Tj 0.0246 Tc 10.3 0 0 10.3 238.61 107.2796 Tm (mmHg\) )Tj 0.0257 Tc -19.029 -1.075 Td (without )Tj 0.0116 Tc 3.498 0 Td (deleterious )Tj 0.0086 Tc 4.793 0 Td (changes )Tj 0.0107 Tc 3.602 0 Td (in )Tj 0.0215 Tc 1.105 0 Td (haemodynamic )Tj 0.005 Tc 6.663 0 Td (values )Tj 0.05 Tc 10.8872 0 0 10.3 42.52 85.3696 Tm (or )Tj 0.034 Tc 10.3 0 0 10.3 55.06 85.3696 Tm (in )Tj 0.013 Tc 1.151 0 Td (ventilation)Tj 0.286 0.286 0.275 rg 0 Tc 4.493 0 Td (. )Tj ET BT /Suspect <>BDC 0.161 0.161 0.149 rg /T1_0 1 Tf 0.05 Tc 10.4048 0 0 10.3 307.88 502.4396 Tm (On )Tj EMC ET BT /T1_0 1 Tf 0.0066 Tc 10.3 0 0 10.3 326.66 502.4396 Tm (average, )Tj 0.0218 Tc 4.01 0 Td (patients )Tj 0.05 Tc 10.3262 0 0 10.3 407.18 502.4396 Tm (had )Tj 0.0275 Tc 10.3 0 0 10.3 428.85 502.4396 Tm (moderate )Tj 0.019 Tc 4.489 0 Td (hypoxaemia )Tj 0.0438 Tc -17.192 -1.052 Td (and )Tj 0.0062 Tc 2.083 0 Td (low )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 12.2982 0 0 10.3 340.37 491.5996 Tm (C0)Tj 0 Tc 6.4001 0 0 6.4001 355.63 489.1996 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0239 Tc 10.3 0 0 10.3 364.8 491.5996 Tm (retention )Tj 0.0096 Tc 4.266 0 Td (similar )Tj 0.0436 Tc 3.354 0 Td (to )Tj 0.0107 Tc 1.403 0 Td (the )Tj 0.0215 Tc 1.801 0 Td (majority )Tj 0.05 Tc 11.1664 0 0 10.3 518.58 491.5996 Tm (of )Tj 0.0218 Tc 10.3 0 0 10.3 297.89 480.7696 Tm (patients )Tj 0.0231 Tc 4.017 0 Td (treated )Tj 0.0149 Tc 3.581 0 Td (by )Tj 0.0126 Tc 1.742 0 Td (almitrine )Tj 0.0087 Tc 4.453 0 Td (bismesylate )Tj 0.0107 Tc 5.508 0 Td (in )Tj 0.05 Tc 10.569 0 0 10.3 512.33 480.7696 Tm (our )Tj 0.0253 Tc 10.3 0 0 10.3 297.53 469.6896 Tm (country. )Tj 0.0383 Tc 3.952 0 Td (The )Tj 0.0219 Tc 2.063 0 Td (therapeutic )Tj 0.0285 Tc 5.089 0 Td (aim )Tj 0.034 Tc 1.942 0 Td (in )Tj 0.0134 Tc 1.257 0 Td (such )Tj 0.0318 Tc 2.307 0 Td (patients )Tj -0.0186 Tc 3.73 0 Td (is )Tj 0.0436 Tc 1.105 0 Td (to )Tj 0.0205 Tc -21.444 -1.052 Td (improve )Tj -0.0174 Tc 3.787 0 Td (life )Tj 0.0147 Tc 1.612 0 Td (quality )Tj 0.0316 Tc 3.202 0 Td (and, )Tj 0.05 Tc 10.8462 0 0 10.3 408.31 458.8496 Tm (if )Tj 0.0018 Tc 10.3 0 0 10.3 417.81 458.8496 Tm (possible, )Tj 0.0436 Tc 3.9 0 Td (to )Tj 0.0167 Tc 1.185 0 Td (delay )Tj 0 Tc 2.572 0 Td (oxygen )Tj 0.0232 Tc -19.304 -1.075 Td (therapy )Tj 0.05 Tc 10.3744 0 0 10.3 333.89 447.7796 Tm (and )Tj 0.0117 Tc 10.3 0 0 10.3 353.41 447.7796 Tm (lengthen )Tj 0.005 Tc 3.851 0 Td (survival. )Tj 0.0383 Tc -8.317 -1.052 Td (The )Tj 0.0115 Tc 1.901 0 Td (need )Tj 0.0436 Tc 2.243 0 Td (to )Tj 0.0266 Tc 1.1 0 Td (repeat )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.3398 0 0 10.3 390.78 436.9396 Tm (Ppa )Tj EMC ET BT /T1_0 1 Tf 0.0144 Tc 10.3 0 0 10.3 410.07 436.9396 Tm (measurements )Tj 0.0055 Tc 6.165 0 Td (led )Tj 0 Tc 1.551 0 Td (us )Tj 0.0202 Tc 1.19 0 Td (to )Tj 0.0006 Tc 1.101 0 Td (use )Tj 0.037 Tc -20.934 -1.099 Td (Grandjean)Tj 0.286 0.286 0.275 rg 0 Tc 4.511 0 Td (')Tj 0.161 0.161 0.149 rg 0.254 0 Td (s )Tj 0.0009 Tc 0.657 0 Td (floating )Tj 0.0292 Tc 3.439 0 Td (catheter )Tj -0.035 Tc 8.8547 0 0 10.3 426.49 425.6196 Tm ([9] )Tj -0.0027 Tc 10.3 0 0 10.3 439.84 425.6196 Tm (as )Tj 0.05 Tc 10.545 0 0 10.3 451.64 425.6196 Tm (an )Tj 0.02 Tc 10.3 0 0 10.3 465.12 425.6196 Tm (easier )Tj 0.0438 Tc 2.713 0 Td (and )Tj -0.0189 Tc 1.849 0 Td (less )Tj 0.001 Tc -20.853 -1.075 Td (invasive )Tj 0.0327 Tc 3.606 0 Td (method )Tj 0.0431 Tc 3.46 0 Td (than )Tj 0.0341 Tc 2.15 0 Td (the )Tj 0.0236 Tc 1.55 0 Td (Swan-Ganz )Tj 0.0359 Tc 5.082 0 Td (catheter)Tj 0.376 0.376 0.365 rg 0 Tc 3.45 0 Td (. )Tj 0.161 0.161 0.149 rg 0.0181 Tc 0.505 0 Td (Initial )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.3398 0 0 10.3 297.34 403.7096 Tm (Ppa )Tj EMC ET BT /T1_0 1 Tf 0.0097 Tc 10.3 0 0 10.3 318.56 403.7096 Tm (values )Tj -0.0065 Tc 3.04 0 Td (were )Tj 0.003 Tc 2.372 0 Td (slightly )Tj 0.0044 Tc 3.466 0 Td (increased, )Tj 0.05 Tc 10.3901 0 0 10.3 457.06 403.7096 Tm (but )Tj 0.0013 Tc 10.3 0 0 10.3 476.05 403.7096 Tm (were )Tj -0.0127 Tc 2.401 0 Td (in )Tj 0.0224 Tc 1.246 0 Td (the )Tj 0.0181 Tc -20.993 -1.052 Td (range )Tj 0.05 Tc 11.4455 0 0 10.3 324.73 392.8696 Tm (of )Tj 0.0004 Tc 10.3 0 0 10.3 337.34 392.8696 Tm (values )Tj 0.0288 Tc 2.9 0 Td (reported )Tj 0.0383 Tc 3.907 0 Td (by )Tj -0.035 Tc 8.7775 0 0 10.3 421.37 392.8696 Tm (WEITZENBLUM )Tj /T1_2 1 Tf 0.05 Tc 10.5037 0 0 10.2 485.85 392.8696 Tm (et )Tj -0.035 Tc 10.1586 0 0 10.2 497.43 392.8696 Tm (al. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.7862 0 0 10.3 511.23 392.8696 Tm ([30] )Tj EMC ET BT /T1_0 1 Tf 0.034 Tc 10.3 0 0 10.3 297.07 382.0396 Tm (in )Tj 0.0174 Tc 1.256 0 Td (similar )Tj 0.0229 Tc 3.242 0 Td (patients. )Tj 0.0266 Tc 4.034 0 Td (The )Tj 0.0123 Tc 2.044 0 Td (use )Tj 0.05 Tc 10.8872 0 0 10.3 424.67 382.0396 Tm (of )Tj 0.0341 Tc 10.3 0 0 10.3 437.92 382.0396 Tm (Grandjean )Tj 0.0207 Tc 4.91 0 Td (catheters )Tj 0.0173 Tc -18.578 -1.076 Td (with )Tj 0.0224 Tc 2.617 0 Td (the )Tj 0.0071 Tc 2.021 0 Td (smallest )Tj 0.0275 Tc 4.05 0 Td (internal )Tj 0.0125 Tc 3.997 0 Td (diameter, )Tj 0.0081 Tc 4.66 0 Td (necessitated )Tj 0.0244 Tc -17.371 -1.076 Td (measurement )Tj 0.05 Tc 10.8872 0 0 10.3 358.93 359.8796 Tm (of )Tj 0.0257 Tc 10.3 0 0 10.3 371.94 359.8796 Tm (cardiac )Tj 0.045 Tc 3.46 0 Td (output )Tj 0.0077 Tc 3.204 0 Td (indirectly. )Tj 0 Tc 4.657 0 Td (We )Tj 0.013 Tc 1.804 0 Td (used )Tj 0.0224 Tc -20.388 -1.075 Td (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 12.2982 0 0 10.3 315.08 348.8096 Tm (C0)Tj 0 Tc 6.9001 0 0 6.9001 330.58 346.3996 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0221 Tc 10.3 0 0 10.3 339.52 348.8096 Tm (rebreathing )Tj 0.0285 Tc 5.213 0 Td (method, )Tj -0.0015 Tc 3.905 0 Td (which )Tj 0.0256 Tc 2.946 0 Td (has )Tj 0.0058 Tc 1.896 0 Td (been )Tj -0.0061 Tc 2.382 0 Td (vali\255)Tj 0.0343 Tc -20.464 -1.052 Td (dated )Tj 0.034 Tc 3.041 0 Td (in )Tj -0.0039 Tc 1.55 0 Td (he)Tj 0.286 0.286 0.275 rg 0 Tc 0.95 0 Td (a)Tj 0.161 0.161 0.149 rg 0.0092 Tc 0.492 0 Td (lthy )Tj 0.0081 Tc 2.309 0 Td (subjects )Tj -0.035 Tc 9.6842 0 0 10.3 424.3 337.9696 Tm ([29]. )Tj 0.05 Tc 10.5385 0 0 10.3 449.5 337.9696 Tm (In )Tj 0.0285 Tc 10.3 0 0 10.3 466.45 337.9696 Tm (patients )Tj 0.0173 Tc 3.995 0 Td (with )Tj 0.0231 Tc -20.433 -1.075 Td (respiratory )Tj -0.0087 Tc 4.901 0 Td (diseases )Tj 0.0224 Tc 3.561 0 Td (the )Tj 0.0124 Tc 1.582 0 Td (accuracy )Tj 0.05 Tc 11.1664 0 0 10.3 441.28 326.8996 Tm (of )Tj 0.0134 Tc 10.3 0 0 10.3 453.29 326.8996 Tm (such )Tj 0 Tc 2.201 0 Td (a )Tj 0.028 Tc 0.803 0 Td (method )Tj -0.0186 Tc 3.454 0 Td (is )Tj 0.0221 Tc -21.65 -1.076 Td (question)Tj 0.286 0.286 0.275 rg 0 Tc 3.553 0 Td (a)Tj 0.161 0.161 0.149 rg -0.009 Tc 0.549 0 Td (ble )Tj 0.0107 Tc 1.884 0 Td (in )Tj -0.0299 Tc 1.48 0 Td (view )Tj 0 Tc 2.563 0 Td (o)Tj 0.286 0.286 0.275 rg 0.56 0 Td (f )Tj 0.161 0.161 0.149 rg 0.0341 Tc 1.014 0 Td (the )Tj 0.019 Tc 1.964 0 Td (ventilation/perfusion )Tj 0.0158 Tc -13.583 -1.052 Td (mismatch. )Tj -0.035 Tc 8.8065 0 0 10.3 344.07 304.9796 Tm (DAVIS )Tj /T1_2 1 Tf 0.0489 Tc 10.2 0 0 10.2 372.43 304.9796 Tm (et )Tj -0.0251 Tc 1.018 0 Td (al. )Tj /T1_0 1 Tf -0.035 Tc 9.3088 0 0 10.3 396.14 304.9796 Tm ([7] )Tj 0.0117 Tc 10.3 0 0 10.3 409.35 304.9796 Tm (have )Tj 0.0254 Tc 2.198 0 Td (reported )Tj 0.05 Tc 10.542 0 0 10.3 470.98 304.9796 Tm (that )Tj 0.0107 Tc 10.3 0 0 10.3 491.21 304.9796 Tm (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 12.2982 0 0 10.3 507 304.9796 Tm (C0)Tj 0 Tc 6.4001 0 0 6.4001 522.26 302.3296 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0244 Tc 10.3 0 0 10.3 296.9 293.9096 Tm (rebreathing )Tj 0.0327 Tc 5.025 0 Td (method )Tj 0.0153 Tc 3.405 0 Td (for )Tj 0.0151 Tc 1.482 0 Td (measuring )Tj 0.0257 Tc 4.504 0 Td (cardiac )Tj 0.045 Tc 3.274 0 Td (output )Tj 0.0084 Tc 3.001 0 Td (was )Tj 0.0067 Tc -20.715 -1.052 Td (reliable )Tj 0.0107 Tc 3.383 0 Td (in )Tj 0.0022 Tc 1.163 0 Td (seriously )Tj /T1_1 1 Tf 0.05 Tc 10.9494 0 0 9.8 383.87 283.0696 Tm (ill )Tj /T1_0 1 Tf 0.0252 Tc 10.3 0 0 10.3 395.65 283.0696 Tm (patients )Tj 0.0107 Tc 3.587 0 Td (\(including )Tj 0.0208 Tc 4.546 0 Td (respiratory )Tj 0.0073 Tc -17.752 -1.099 Td (distress )Tj 0.0118 Tc 3.573 0 Td (syndrome\). )Tj 0.0181 Tc 5.197 0 Td (Indeed, )Tj 0.0022 Tc 3.608 0 Td (using )Tj 0.0254 Tc 2.678 0 Td (arterial )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.4918 0 0 10.3 488.3 271.7496 Tm (Pco)Tj 0 Tc 6.7 0 0 6.7 505.41 269.3396 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0025 Tc 10.3 0 0 10.3 514.51 271.7496 Tm (in\255)Tj 0.0193 Tc -21.141 -1.051 Td (stead )Tj 0.05 Tc 11.1664 0 0 10.3 322.33 260.9196 Tm (of )Tj 0.0248 Tc 10.3 0 0 10.3 334.61 260.9196 Tm (end )Tj 0.013 Tc 1.878 0 Td (tidal )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.6439 0 0 10.3 376.57 260.9196 Tm (Pco)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 394.14 258.7496 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0119 Tc 10.3 0 0 10.3 401.63 260.9196 Tm (they )Tj 0.0081 Tc 2.119 0 Td (found )Tj 0 Tc 2.783 0 Td (a )Tj 0.0021 Tc 0.803 0 Td (very )Tj 0.0041 Tc 2.139 0 Td (significant )Tj 0.0276 Tc -18.067 -1.052 Td (correlation )Tj 0.0275 Tc 5.071 0 Td (\(n )Tj 0 Tc 1.013 0 Td (= )Tj -0.035 Tc 9.7543 0 0 10.3 368.09 250.0796 Tm (18; )Tj 0 Tc 10.3 0 0 10.3 384.55 250.0796 Tm [(r )49(= )]TJ -0.0077 Tc 1.347 0 Td (0.935)Tj 0.286 0.286 0.275 rg 0 Tc 2.282 0 Td (; )Tj 0.161 0.161 0.149 rg 0.677 0 Td [(p )79(< )]TJ ET BT /Suspect <>BDC /T1_0 1 Tf -0.012 Tc 10.3 0 0 10.3 444.1767 250.0796 Tm (0.001\) )Tj EMC ET BT /T1_0 1 Tf 0.008 Tc 10.3 0 0 10.3 475.1282 250.0796 Tm (between )Tj -0.0049 Tc 3.831 0 Td (re\255)Tj 0.0293 Tc -21.155 -1.076 Td (breathing )Tj 0.0438 Tc 4.383 0 Td (and )Tj 0.0195 Tc 1.895 0 Td (direct )Tj 0.0294 Tc 2.763 0 Td (Fick )Tj 0.0122 Tc 2.248 0 Td (methods. )Tj 0.0073 Tc 4.168 0 Td (Similarly)Tj 0.286 0.286 0.275 rg 0 Tc 3.814 0 Td (, )Tj 0.161 0.161 0.149 rg -0.035 Tc 9.4416 0 0 10.3 501.55 238.9996 Tm (MAH\255)Tj 8.2771 0 0 10.3 296.38 228.1696 Tm (LER )Tj /T1_2 1 Tf 0.0489 Tc 10.2 0 0 10.2 314.88 228.1696 Tm (et )Tj -0.0251 Tc 1.112 0 Td (al. )Tj /T1_0 1 Tf -0.035 Tc 9.7862 0 0 10.3 340.26 228.1696 Tm ([13] )Tj 0.0085 Tc 10.3 0 0 10.3 359.42 228.1696 Tm (observed )Tj 0.286 0.286 0.275 rg 0 Tc 4.02 0 Td (a )Tj 0.161 0.161 0.149 rg 0.0243 Tc 0.853 0 Td (better )Tj 0.0276 Tc 2.701 0 Td (correlation )Tj 0.0309 Tc 4.954 0 Td (\(r )Tj 0 Tc 0.849 0 Td (= )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0005 Tc 10.3 0 0 10.3 505.3298 228.1696 Tm (0.84)Tj 0.286 0.286 0.275 rg 0 Tc 1.767 0 Td (; )Tj EMC ET BT 0.161 0.161 0.149 rg /T1_0 1 Tf 10.3 0 0 10.3 296.4252 217.0868 Tm [(p )55(= )]TJ ET BT /Suspect <>BDC /T1_0 1 Tf -0.0026 Tc 10.3 0 0 10.3 311.9576 217.0868 Tm (0.009\) )Tj EMC ET BT /T1_0 1 Tf 0.0041 Tc 10.3 0 0 10.3 343.6301 217.0868 Tm (between )Tj 0.0107 Tc 3.877 0 Td (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 12.2982 0 0 10.3 401.77 217.0896 Tm (C0)Tj 0 Tc 6.4001 0 0 6.4001 417.27 214.9196 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0197 Tc 10.3 0 0 10.3 426.45 217.0896 Tm (rebreathing )Tj 0.05 Tc 10.3744 0 0 10.3 480.54 217.0896 Tm (and )Tj 0.0148 Tc 10.3 0 0 10.3 501.74 217.0896 Tm (direct )Tj 0.0216 Tc -19.915 -1.076 Td (Fick )Tj 0.0287 Tc 2.223 0 Td (methods )Tj 0.0107 Tc 3.921 0 Td (in )Tj 0.0342 Tc 1.152 0 Td (moderate )Tj 0.0401 Tc 4.316 0 Td (air )Tj -0.0326 Tc 1.472 0 Td (flow )Tj 0.0294 Tc 2.152 0 Td (obstruction )Tj 0.05 Tc 10.4437 0 0 10.3 506.38 206.0096 Tm (than )Tj 0.0107 Tc 10.3 0 0 10.3 296.34 195.1796 Tm (in )Tj -0.0002 Tc 1.093 0 Td (severe )Tj 0.0104 Tc 2.856 0 Td (airway )Tj -0.0022 Tc 3.086 0 Td (disease. )Tj 0.0148 Tc 3.488 0 Td (However)Tj 0.286 0.286 0.275 rg 0 Tc 3.777 0 Td (, )Tj 0.161 0.161 0.149 rg 0.0029 Tc 0.574 0 Td (this )Tj 0.0318 Tc 1.771 0 Td (good )Tj 0.0135 Tc 2.43 0 Td (correla\255)Tj 0.0205 Tc -19.07 -1.076 Td (tion )Tj 0.0084 Tc 2.082 0 Td (was )Tj 0.0128 Tc 2.025 0 Td (associated )Tj 0.0173 Tc 4.661 0 Td (with )Tj 0.05 Tc 10.545 0 0 10.3 410.22 184.0996 Tm (an )Tj 0.0229 Tc 10.3 0 0 10.3 425.26 184.0996 Tm (underestimation )Tj 0.05 Tc 10.6081 0 0 10.3 499.56 184.0996 Tm (of )Tj 0.0224 Tc 10.3 0 0 10.3 512.64 184.0996 Tm (the )Tj 0.0175 Tc -21.023 -1.076 Td (indirect )Tj 0.005 Tc 3.63 0 Td (values)Tj 0.478 0.478 0.467 rg 0 Tc 2.623 0 Td (. )Tj 0.161 0.161 0.149 rg -0.035 Tc 8.8436 0 0 10.3 367.37 173.0196 Tm (CHABRILLAT )Tj /T1_2 1 Tf 0.0253 Tc 10.2 0 0 10.2 424.93 173.0196 Tm (et )Tj 0.0345 Tc 1.182 0 Td (al)Tj 0.286 0.286 0.275 rg 0 Tc 0.8 0 Td (. )Tj 0.161 0.161 0.149 rg /T1_0 1 Tf -0.035 Tc 9.3088 0 0 10.3 452 173.0196 Tm ([6] )Tj 0.0129 Tc 10.3 0 0 10.3 467.07 173.0196 Tm (improved )Tj 0.0341 Tc 4.401 0 Td (the )Tj 0.0096 Tc -21.002 -1.051 Td (Cerretelli )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 12.2982 0 0 10.3 341.09 162.1896 Tm (C0)Tj 0 Tc 6.2 0 0 6.2 356.35 160.0196 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0267 Tc 10.3 0 0 10.3 365.04 162.1896 Tm (rebreathing )Tj 0.0219 Tc 5.286 0 Td (procedure )Tj -0.0085 Tc 4.652 0 Td (by )Tj 0.0173 Tc 1.462 0 Td (correcting )Tj 0.0224 Tc -18.088 -1.076 Td (the )Tj 0.0353 Tc 1.571 0 Td (plateau )Tj 0.0097 Tc 3.389 0 Td (pressures )Tj 0.0173 Tc 4.112 0 Td (with )Tj 0.0107 Tc 2.174 0 Td (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 12.0966 0 0 10.3 428.02 151.1096 Tm (C0)Tj 0 Tc 6.4001 0 0 6.4001 443.04 148.9396 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.3744 0 0 10.3 450.2 151.1096 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 10.3 0 0 10.3 469.22 151.1096 Tm (0)Tj 6.4001 0 0 6.4001 477.48 148.9396 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0365 Tc 10.3 0 0 10.3 484.39 151.1096 Tm (end )Tj 0.0092 Tc 1.831 0 Td (tidal\255)Tj 0.0254 Tc -20.114 -1.052 Td (arterial )Tj 0.0165 Tc 3.355 0 Td (pressure )Tj -0.0033 Tc 3.752 0 Td (differences )Tj 0.034 Tc 4.748 0 Td (in )Tj 0.0331 Tc 1.144 0 Td (order )Tj 0.0202 Tc 2.58 0 Td (to )Tj 0.0424 Tc 1.161 0 Td (obtain )Tj -0.0036 Tc 3.048 0 Td (mixed )Tj 0.0098 Tc -19.802 -1.075 Td (venous )Tj 0.0068 Tc 3.183 0 Td (pressures. )Tj 0.0225 Tc 4.316 0 Td (They )Tj 0.0118 Tc 2.384 0 Td (observed )Tj 0 Tc 3.95 0 Td (a )Tj 0.0064 Tc 0.744 0 Td (significant )Tj 0.0102 Tc 4.517 0 Td (correla\255)Tj 0.0283 Tc -19.093 -1.052 Td (tion )Tj 0.0173 Tc 2.316 0 Td (with )Tj 0.0004 Tc 2.524 0 Td (values )Tj 0.0325 Tc 3.218 0 Td (obtained )Tj 0.0149 Tc 4.36 0 Td (by )Tj 0.0224 Tc 1.655 0 Td (the )Tj 0.0218 Tc 1.964 0 Td (thermodilution )Tj 0.0176 Tc -16.038 -1.076 Td (technique )Tj 0.05 Tc 11.7806 0 0 10.3 348.06 107.2796 Tm (\(r=0)Tj 0.286 0.286 0.275 rg 0 Tc 10.3 0 0 10.3 370.62 107.2796 Tm (.)Tj 0.161 0.161 0.149 rg -0.0273 Tc 0.237 0 Td (897; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0495 Tc 10.3 0 0 10.3 401.4273 107.2796 Tm (p<0.001; )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 12.1519 0 0 10.3 452.93 107.2796 Tm (n= )Tj -0.035 Tc 10.1042 0 0 10.3 469.21 107.2796 Tm (19\) )Tj 0.0257 Tc 10.3 0 0 10.3 492.43 107.2796 Tm (without )Tj 0.0246 Tc -19.099 -1.075 Td (underestimation )Tj 0.0207 Tc 7.026 0 Td (as )Tj 0.0206 Tc 1.078 0 Td (long )Tj 0.0207 Tc 2.079 0 Td (as )Tj 0.0218 Tc 1.076 0 Td (cardiac )Tj 0.05 Tc 10.381 0 0 10.3 444.9 96.2096 Tm (output )Tj 0.0084 Tc 10.3 0 0 10.3 476.29 96.2096 Tm (was )Tj 0.0053 Tc 1.811 0 Td (smaller )Tj 0.05 Tc 10.3147 0 0 10.3 295.68 85.3696 Tm (than )Tj 0 Tc 10.3 0 0 10.3 322.01 85.3696 Tm (8 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.5552 0 0 10.3 333.99 85.3696 Tm (/\267min )Tj EMC /Suspect <>BDC 0.565 0.565 0.553 rg 0 Tc 10.3 0 0 10.3 359.64 85.3696 Tm (-)Tj 0.161 0.161 0.149 rg 6.2 0 0 6.2 365.57 89.2196 Tm (1)Tj 0.679 -0.621 Td (\225 )Tj EMC ET BT /T1_0 1 Tf 0.0169 Tc 10.3 0 0 10.3 378.76 85.3696 Tm 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/Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.345 0 0 9.5 409.03 644.9996 Tm (0.31 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 440.98 644.9996 Tm (8)Tj 0.326 0.326 0.318 rg 0.504 0 Td (.)Tj 0.153 0.153 0.145 rg -0.035 Tc 8.9623 0 0 9.5 447.78 644.9996 Tm (63 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.5674 0 0 9.5 458.72 644.9996 Tm (\2610.24 )Tj EMC /Suspect <>BDC -0.0185 Tc 9.5 0 0 9.5 498.36 644.7496 Tm (0.039 )Tj EMC ET BT /T1_0 1 Tf -0.0013 Tc 9.5 0 0 9.5 69.093 632.9601 Tm (kPa )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0168 Tc 9.5 0 0 9.5 69.3115 611.5186 Tm (Paco)Tj 0 Tc 6.2 0 0 6.2 88.1 607.9096 Tm (2 )Tj EMC /Suspect <>BDC 0.0401 Tc 9.5 0 0 9.5 140.98 611.0396 Tm (5.94\2610.10 )Tj EMC ET BT /T1_0 1 Tf -0.0312 Tc 9.5 0 0 9.5 219.241 611.0396 Tm (5.63 )Tj 0 Tc 1.888 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.345 0 0 9.5 244.56 611.0396 Tm (0.11 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 276.31 611.0396 Tm (5)Tj 0.326 0.326 0.318 rg 0.525 0 Td (.)Tj 0.153 0.153 0.145 rg -0.035 Tc 9.0811 0 0 9.5 283.32 611.0396 Tm (36 )Tj 0 Tc 9.5 0 0 9.5 294.25 611.0396 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.4933 0 0 9.5 301.63 611.0396 Tm (0.17 )Tj EMC ET BT /T1_0 1 Tf -0.0227 Tc 9.5 0 0 9.5 330.73 611.0396 Tm (5.13 )Tj 0 Tc 1.915 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.5 0 0 9.5 356.532 611.0396 Tm (0)Tj 0.267 0.267 0.259 rg 0.497 0 Td (.)Tj 0.153 0.153 0.145 rg -0.035 Tc 8.8927 0 0 9.5 363.55 611.0396 Tm (13 )Tj EMC ET BT /T1_0 1 Tf -0.0312 Tc 9.5 0 0 9.5 383.47 611.0396 Tm (5.28 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0417 Tc 9.5 0 0 9.5 401.653 611.0396 Tm (\2610.10 )Tj EMC /Suspect <>BDC 0.0401 Tc 4.119 0.025 Td (5.20\2610.18 )Tj EMC ET BT /T1_0 1 Tf -0.014 Tc 9.5 0 0 9.5 69.096 599.4781 Tm (kPa )Tj -0.035 Tc 9.4032 0 0 9.5 68.88 577.0896 Tm (pH )Tj -0.0344 Tc 9.5 0 0 9.5 140.77 577.0896 Tm (7.42 )Tj 0 Tc 1.86 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.1967 0 0 9.5 166.06 577.0896 Tm (0.01 )Tj EMC ET BT /T1_0 1 Tf 9.3623 0 0 9.5 219.03 576.8496 Tm (7.41 )Tj 0 Tc 9.5 0 0 9.5 236.94 576.8496 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.2281 0 0 9.5 244.33 576.8496 Tm (O.Dl )Tj EMC /Suspect <>BDC -0.0259 Tc 9.5 0 0 9.5 276.34 576.8496 Tm (7.40 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 294.01 576.8496 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.345 0 0 9.5 301.39 576.8496 Tm (0.01 )Tj EMC ET BT /T1_0 1 Tf -0.0344 Tc 9.5 0 0 9.5 331 576.8496 Tm (7.43 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0164 Tc 9.5 0 0 9.5 348.917 576.8496 Tm (\2610.01 )Tj EMC ET BT /T1_0 1 Tf -0.0259 Tc 9.5 0 0 9.5 383.497 577.0871 Tm (7.42 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0227 Tc 9.5 0 0 9.5 401.6515 577.0871 Tm (\2610.01 )Tj EMC ET BT /T1_0 1 Tf -0.0344 Tc 9.5 0 0 9.5 440.573 577.0871 Tm (7.41 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 11.2489 0 0 9.5 458.72 577.0896 Tm (\2610)Tj 0.326 0.326 0.318 rg 0 Tc 9.5 0 0 9.5 471.29 577.0896 Tm (.)Tj 0.153 0.153 0.145 rg -0.035 Tc 9.1891 0 0 9.5 473.08 577.0896 Tm (01 )Tj EMC /Suspect <>BDC 9.4551 0 0 9.5 498.6 577.0896 Tm (0.935 )Tj EMC ET BT /T1_0 1 Tf -0.0098 Tc 9.5 0 0 9.5 68.94 555.4196 Tm (Sao)Tj 0 Tc 6.2 0 0 6.2 83.04 552.2896 Tm (2 )Tj -0.035 Tc 9.4234 0 0 9.5 140.7 554.9396 Tm (89.6 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 11.0283 0 0 9.5 158.44 554.9396 Tm (\2612)Tj 0.267 0.267 0.259 rg 0 Tc 9.5 0 0 9.5 170.77 554.9396 Tm (.)Tj 0.153 0.153 0.145 rg 0.214 0 Td (0 )Tj EMC ET BT /T1_0 1 Tf -0.0303 Tc 9.5 0 0 9.5 214.451 554.9396 Tm (92.5* )Tj 0 Tc 2.342 0 Td (\261 )Tj -0.019 Tc 0.854 0 Td (1.2 )Tj -0.035 Tc 9.47 0 0 9.5 271.76 554.9396 Tm (93.1* )Tj 0 Tc 9.5 0 0 9.5 293.77 554.9396 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.019 Tc 9.5 0 0 9.5 301.883 554.9396 Tm (1.0 )Tj EMC /Suspect <>BDC 0.0362 Tc 3.065 0.025 Td (92.7\2610.8 )Tj EMC /Suspect <>BDC 0.05 Tc 9.9568 0 0 9.5 383.49 555.1796 Tm (93.4\2610)Tj 0.326 0.326 0.318 rg 0 Tc 9.5 0 0 9.5 413.74 555.1796 Tm (.)Tj 0.153 0.153 0.145 rg 0.237 0 Td (6 )Tj EMC /Suspect <>BDC -0.0119 Tc 2.586 0.025 Td (92)Tj 0.267 0.267 0.259 rg 0 Tc 1.004 0 Td (.)Tj 0.153 0.153 0.145 rg 0.05 Tc 10.3211 0 0 9.5 452.11 555.4196 Tm (9\2610.7 )Tj EMC /Suspect <>BDC -0.0185 Tc 9.5 0 0 9.5 498.36 555.1796 Tm (0.044 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 69.02 543.6196 Tm (% )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0428 Tc 9.5 0 0 9.5 68.83 520.9796 Tm (HCO\) )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.3295 0 0 9.5 140.33 521.2196 Tm (28.1 )Tj 0 Tc 9.5 0 0 9.5 158.44 521.2196 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.3545 0 0 9.5 166.06 521.2196 Tm (0.7 )Tj EMC ET BT /T1_0 1 Tf -0.0278 Tc 9.5 0 0 9.5 218.83 521.2196 Tm (25.8 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0449 Tc 9.5 0 0 9.5 236.937 521.2196 Tm (\2610.5 )Tj EMC ET BT /T1_0 1 Tf -0.0278 Tc 9.5 0 0 9.5 275.8965 521.2196 Tm (24.3 )Tj 0 Tc 1.881 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0185 Tc 9.5 0 0 9.5 301.385 521.2196 Tm (0.6 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.3295 0 0 9.5 330.81 521.2196 Tm (25.1 )Tj 0 Tc 9.5 0 0 9.5 348.68 521.2196 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0312 Tc 9.5 0 0 9.5 356.052 521.2196 Tm (0.5 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.1814 0 0 9.5 383.54 521.2196 Tm (25.1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.6731 0 0 9.5 401.41 521.2196 Tm (\2610.6 )Tj EMC /Suspect <>BDC -0.035 Tc 9.1628 0 0 9.5 440.86 521.4596 Tm (23)Tj 0.326 0.326 0.318 rg 0 Tc 9.5 0 0 9.5 450.1 521.4596 Tm (.)Tj 0.153 0.153 0.145 rg 0.05 Tc 10.1683 0 0 9.5 452.53 521.4596 Tm (8\2610.7 )Tj EMC /Suspect <>BDC -0.0185 Tc 9.5 0 0 9.5 498.36 521.4596 Tm (0.060 )Tj EMC ET BT /T1_2 1 Tf 0.0285 Tc 9.3 0 0 9.3 68.35 509.4196 Tm (mmol/l )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 68.59 487.5096 Tm (P )Tj EMC ET BT /T1_0 1 Tf -0.0046 Tc 9.5 0 0 9.5 75.981 487.5096 Tm (\(a-ET\)C0)Tj 0 Tc 6.2 0 0 6.2 111.7 483.8996 Tm (2 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.1967 0 0 9.5 140.53 487.0296 Tm (0.68 )Tj EMC /Suspect <>BDC 0.0354 Tc 9.5 0 0 9.5 158.2 487.0296 Tm (\2610.09 )Tj EMC /Suspect <>BDC 0.0456 Tc 6.124 0 Td (0.40\261 )Tj EMC /Suspect <>BDC 0 Tc 2.687 0 Td (0)Tj 0.267 0.267 0.259 rg 0.522 0 Td (.)Tj 0.153 0.153 0.145 rg -0.035 Tc 9.4317 0 0 9.5 249.15 487.0296 Tm (12 )Tj EMC /Suspect <>BDC 9.0483 0 0 9.5 276.11 487.0296 Tm (0.41 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 293.77 487.0296 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.345 0 0 9.5 301.15 487.0296 Tm (0.11 )Tj EMC /Suspect <>BDC -0.0269 Tc 9.5 0 0 9.5 328.6 487.0296 Tm (0.47 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 346.5075 487.0296 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.5 0 0 9.5 354.117 487.0296 Tm (0)Tj 0.404 0.408 0.396 rg 0.472 0 Td (.)Tj 0.153 0.153 0.145 rg -0.035 Tc 8.8927 0 0 9.5 360.9 487.0296 Tm (11 )Tj EMC /Suspect <>BDC 9.4933 0 0 9.5 383.26 487.0296 Tm (0.47 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 401.41 487.0296 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0185 Tc 9.5 0 0 9.5 408.782 487.0296 Tm (0.12 )Tj EMC /Suspect <>BDC 0 Tc 3.346 0.025 Td (0)Tj 0.267 0.267 0.259 rg 0.547 0 Td (.)Tj 0.153 0.153 0.145 rg 0.05 Tc 10.1466 0 0 9.5 447.51 487.2696 Tm (52\261 )Tj EMC /Suspect <>BDC -0.0269 Tc 9.5 0 0 9.5 466.34 487.2696 Tm (0.16 )Tj EMC /Suspect <>BDC -0.0248 Tc 3.371 -0.025 Td (0.252 )Tj EMC ET BT /T1_0 1 Tf -0.0013 Tc 9.5 0 0 9.5 68.138 475.4706 Tm (kPa )Tj -0.0256 Tc 0.023 -2.332 Td (P\(ET-a\)0)Tj 0 Tc 6.2 0 0 6.2 101.82 450.1896 Tm (2 )Tj -0.035 Tc 9.4181 0 0 9.5 140.26 453.0796 Tm (5.36 )Tj 0 Tc 9.5 0 0 9.5 157.96 453.0796 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0269 Tc 9.5 0 0 9.5 165.5695 453.0796 Tm (0.47 )Tj EMC ET BT /T1_0 1 Tf -0.029 Tc 9.5 0 0 9.5 213.7915 453.0796 Tm (4.75 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0417 Tc 9.5 0 0 9.5 231.889 453.0796 Tm (\2610.57 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 275.6745 453.0796 Tm (4)Tj 0.267 0.267 0.259 rg 0.541 0 Td (.)Tj 0.153 0.153 0.145 rg -0.035 Tc 8.7063 0 0 9.5 283.09 453.0796 Tm (75 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0481 Tc 9.5 0 0 9.5 293.53 453.0796 Tm (\2610.50 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 325.773 453.3171 Tm (4)Tj 0.326 0.326 0.318 rg 0.566 0 Td (.)Tj 0.153 0.153 0.145 rg -0.035 Tc 9.3134 0 0 9.5 332.9 453.3196 Tm (55 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0227 Tc 9.5 0 0 9.5 344.1 453.3196 Tm (\2610.48 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.4566 0 0 9.5 383.08 453.3196 Tm (4.73 )Tj 0 Tc 9.5 0 0 9.5 401.41 453.3196 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0269 Tc 9.5 0 0 9.5 409.029 453.3196 Tm (0.40 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.4566 0 0 9.5 440.39 453.5596 Tm (4.31 )Tj 0 Tc 9.5 0 0 9.5 458.72 453.5596 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0185 Tc 9.5 0 0 9.5 466.1015 453.5596 Tm (0.43 )Tj EMC /Suspect <>BDC -0.035 Tc 9.4551 0 0 9.5 498.36 453.3196 Tm (0.147 )Tj EMC ET BT /T1_0 1 Tf -0.014 Tc 9.5 0 0 9.5 68.13 441.2796 Tm (kPa )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0194 Tc 9.5 0 0 9.5 68.1015 419.3631 Tm (Ppa )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 139.855 419.1256 Tm (2)Tj 0.267 0.267 0.259 rg 0.493 0 Td (.)Tj 0.153 0.153 0.145 rg -0.035 Tc 9.3134 0 0 9.5 146.52 419.1196 Tm (53 )Tj 0 Tc 9.5 0 0 9.5 157.72 419.1196 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0185 Tc 9.5 0 0 9.5 165.3295 419.1196 Tm (0.40 )Tj EMC /Suspect <>BDC 0.05 Tc 9.9371 0 0 9.5 211.61 419.1196 Tm (2.47\2610)Tj 0.326 0.326 0.318 rg 0 Tc 9.5 0 0 9.5 242.05 419.1196 Tm (.)Tj 0.153 0.153 0.145 rg -0.035 Tc 9.4174 0 0 9.5 243.64 419.1196 Tm (23 )Tj EMC /Suspect <>BDC 0.05 Tc 9.7781 0 0 9.5 273.49 419.3596 Tm (2.54\2610)Tj 0.267 0.267 0.259 rg 0 Tc 9.5 0 0 9.5 303.7 419.3596 Tm (.)Tj 0.153 0.153 0.145 rg -0.035 Tc 9.4174 0 0 9.5 305.52 419.3596 Tm (28 )Tj EMC /Suspect <>BDC 9.4776 0 0 9.5 325.99 419.3596 Tm (2.03 )Tj EMC /Suspect <>BDC 0.0291 Tc 9.5 0 0 9.5 343.86 419.3596 Tm (\2610.19 )Tj EMC ET BT /T1_0 1 Tf -0.0272 Tc 9.5 0 0 9.5 383.513 419.5971 Tm (1.77 )Tj 0 Tc 1.884 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0185 Tc 9.5 0 0 9.5 408.783 419.5971 Tm (0.14 )Tj EMC ET BT /T1_0 1 Tf 0.0454 Tc 9.5 0 0 9.5 440.8265 419.5971 Tm (1.72\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0269 Tc 9.5 0 0 9.5 466.3435 419.5971 Tm (0.18 )Tj EMC /Suspect <>BDC -0.0311 Tc 3.345 0 Td (0.549 )Tj EMC ET BT /T1_0 1 Tf -0.0266 Tc 9.5 0 0 9.5 68.132 408.5296 Tm (kPa )Tj -0.035 Tc 9.3449 0 0 9.5 67.81 386.3696 Tm (Qc )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0314 Tc 9.5 0 0 9.5 139.63 386.1296 Tm (4.72\2610.31 )Tj EMC ET BT /T1_0 1 Tf -0.029 Tc 9.5 0 0 9.5 211.393 386.1296 Tm (4.77 )Tj 0 Tc 1.879 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0269 Tc 9.5 0 0 9.5 236.853 386.1296 Tm (0.29 )Tj EMC /Suspect <>BDC 0 Tc 3.808 0 Td (4)Tj 0.267 0.267 0.259 rg 0.541 0 Td (.)Tj 0.153 0.153 0.145 rg 0.05 Tc 9.5017 0 0 9.5 280.19 386.1296 Tm (72\2610.27 )Tj EMC ET BT /T1_0 1 Tf -0.0227 Tc 9.5 0 0 9.5 325.67 386.3696 Tm (5.19 )Tj 0 Tc 1.889 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.4933 0 0 9.5 351.23 386.3696 Tm (0.37 )Tj EMC /Suspect <>BDC 0.0369 Tc 9.5 0 0 9.5 383.23 386.3696 Tm (5.02\2610.33 )Tj EMC /Suspect <>BDC -0.035 Tc 9.4181 0 0 9.5 440.54 386.6096 Tm (5.01 )Tj EMC /Suspect <>BDC 0.0481 Tc 9.5 0 0 9.5 458.48 386.6096 Tm (\2610.22 )Tj EMC /Suspect <>BDC -0.0311 Tc 4.147 0 Td (0.818 )Tj EMC /Suspect <>BDC -0.0222 Tc -45.243 -1.216 Td (l\267min )Tj EMC ET BT /T1_0 1 Tf -0.0224 Tc 9.5 0 0 9.5 67.6215 353.1411 Tm (Ppa/Qc )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.4933 0 0 9.5 139.57 353.1396 Tm (0.59 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 157.48 353.1396 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.4933 0 0 9.5 164.85 353.1396 Tm (0.15 )Tj EMC /Suspect <>BDC 0.0392 Tc 9.5 0 0 9.5 211.33 353.1396 Tm (0.52\261 )Tj EMC /Suspect <>BDC -0.035 Tc 9.4933 0 0 9.5 236.61 353.1396 Tm (0.05 )Tj EMC /Suspect <>BDC 3.855 0 Td (0.56 )Tj EMC /Suspect <>BDC 0.0291 Tc 9.5 0 0 9.5 291.12 353.1396 Tm (\2610.08 )Tj EMC /Suspect <>BDC 0.0417 Tc 3.616 0.025 Td (0.40\2610.04 )Tj EMC /Suspect <>BDC -0.035 Tc 9.4933 0 0 9.5 383.02 353.3796 Tm (0.36 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 400.93 353.3796 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.4933 0 0 9.5 408.54 353.3796 Tm (0.03 )Tj EMC /Suspect <>BDC -0.0185 Tc 9.5 0 0 9.5 440.33 353.3796 Tm (0.34 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 458.4845 353.3796 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.01 Tc 9.5 0 0 9.5 465.866 353.3796 Tm (0.04 )Tj EMC /Suspect <>BDC -0.035 Tc 9.4551 0 0 9.5 498.12 353.6196 Tm (0.857 )Tj EMC /Suspect <>BDC -0.014 Tc 9.5 0 0 9.5 67.17 341.8196 Tm (kPa)Tj 0.267 0.267 0.259 rg 0 Tc 1.502 0 Td (\267)Tj 0.153 0.153 0.145 rg -0.0158 Tc 0.215 0 Td (l\267min )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.211 0 0 9.5 67.41 320.6296 Tm (VE )Tj -0.0343 Tc 9.5 0 0 9.5 139.32 320.1496 Tm (9.39 )Tj 0.267 0.267 0.259 rg 0 Tc 1.886 0 Td (\261 )Tj ET BT /Suspect <>BDC 0.153 0.153 0.145 rg /T1_0 1 Tf -0.0269 Tc 9.5 0 0 9.5 164.609 320.1496 Tm (0.33 )Tj EMC /Suspect <>BDC -0.035 Tc 9.3317 0 0 9.5 208.69 320.3896 Tm (10.27 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 230.2 320.3896 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0185 Tc 9.5 0 0 9.5 237.819 320.3896 Tm (0.47 )Tj EMC /Suspect <>BDC -0.035 Tc 9.1622 0 0 9.5 270.59 320.3896 Tm (10)Tj 0.267 0.267 0.259 rg 0 Tc 9.5 0 0 9.5 279.38 320.3896 Tm (.)Tj 0.153 0.153 0.145 rg -0.035 Tc 8.796 0 0 9.5 281.62 320.3896 Tm (55 )Tj EMC /Suspect <>BDC 0.0417 Tc 9.5 0 0 9.5 292.33 320.3896 Tm (\2610.74 )Tj EMC ET BT /T1_0 1 Tf -0.0089 Tc 9.5 0 0 9.5 325.4565 320.3896 Tm (9.72 )Tj 0 Tc 1.912 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0269 Tc 9.5 0 0 9.5 350.9925 320.3896 Tm (0.52 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 382.77 320.3896 Tm (9)Tj 0.267 0.267 0.259 rg 0.498 0 Td (.)Tj 0.153 0.153 0.145 rg -0.035 Tc 9.0547 0 0 9.5 389.73 320.3896 Tm (58 )Tj 0 Tc 9.5 0 0 9.5 400.93 320.3896 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.4933 0 0 9.5 408.54 320.3896 Tm (0.48 )Tj EMC /Suspect <>BDC 0.0326 Tc 9.5 0 0 9.5 436.01 320.8696 Tm (10.32\261 )Tj EMC /Suspect <>BDC -0.0185 Tc 3.142 0 Td (0.87 )Tj EMC /Suspect <>BDC -0.0248 Tc 3.371 -0.025 Td (0.552 )Tj EMC /Suspect <>BDC /T1_2 1 Tf -0.0006 Tc 9.3 0 0 9.3 67.32 309.3196 Tm (l\267min )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 13.0504 0 0 14 67.16 287.6396 Tm (vo)Tj 0 Tc 6.2 0 0 6.2 80.15 284.2696 Tm (2 )Tj -0.0343 Tc 9.5 0 0 9.5 139.08 287.6396 Tm (9.39 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0481 Tc 9.5 0 0 9.5 156.997 287.6396 Tm (\2610.02 )Tj EMC /Suspect <>BDC 0 Tc 5.668 0 Td (0)Tj 0.326 0.326 0.318 rg 0.521 0 Td (.)Tj 0.153 0.153 0.145 rg 0.05 Tc 9.8726 0 0 9.5 217.33 287.6396 Tm (32\2610.02 )Tj EMC /Suspect <>BDC -0.035 Tc 9.345 0 0 9.5 270.81 287.6396 Tm (0.31 )Tj EMC /Suspect <>BDC 0.0481 Tc 9.5 0 0 9.5 288.48 287.6396 Tm (\2610.02 )Tj EMC /Suspect <>BDC 0.0392 Tc 3.894 0.025 Td (0.30\261 )Tj EMC /Suspect <>BDC -0.035 Tc 9.1967 0 0 9.5 350.75 287.8796 Tm (0.01 )Tj EMC /Suspect <>BDC 0.05 Tc 9.5295 0 0 9.5 382.54 287.8796 Tm (0.30\261 )Tj EMC /Suspect <>BDC -0.035 Tc 9.1967 0 0 9.5 408.55 287.8796 Tm (0.01 )Tj EMC /Suspect <>BDC 0 Tc 9.5 0 0 9.5 440.09 288.1296 Tm (0)Tj 0.326 0.326 0.318 rg 0.547 0 Td (.)Tj 0.153 0.153 0.145 rg 0.05 Tc 9.6021 0 0 9.5 447.06 288.1296 Tm (32\2610.01 )Tj EMC /Suspect <>BDC -0.0248 Tc 9.5 0 0 9.5 497.88 288.1296 Tm (0.176 )Tj EMC /Suspect <>BDC /T1_2 1 Tf 0 Tc 9.3 0 0 9.3 67.08 275.5996 Tm (l)Tj 0.326 0.326 0.318 rg 0.327 0 Td (\267)Tj 0.153 0.153 0.145 rg 0.036 Tc 0.172 0 Td (min )Tj EMC ET BT /T1_0 1 Tf -0.0158 Tc 9.5 0 0 9.5 66.67 254.1696 Tm (When )Tj -0.0258 Tc 2.612 0 Td (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.02 Tc 9.5 0 0 9.5 105.62 254.1696 Tm (analysis )Tj EMC ET BT /T1_0 1 Tf 0.0239 Tc 9.5 0 0 9.5 137.654 254.1696 Tm (of )Tj -0.0152 Tc 1.046 0 Td (variance )Tj -0.0126 Tc 3.537 0 Td (showed )Tj 0 Tc 3.299 0 Td (a )Tj -0.011 Tc 0.629 0 Td (significant )Tj -0.0151 Tc (difference )Tj -0.0165 Tc 8.507 0 Td (between )Tj -0.024 Tc 3.488 0 Td (groups, )Tj -0.0258 Tc 3.098 0 Td (the )Tj -0.0176 Tc 1.445 0 Td (values )Tj -0.0126 Tc 2.752 0 Td (significantly )Tj -0.0162 Tc 5.075 0 Td (improved )Tj 0.0008 Tc 4.003 0 Td (at )Tj -0.0289 Tc 0.914 0 Td (T6 )Tj -0.035 Tc 9.3709 0 0 9.5 509.92 254.1696 Tm (and )Tj -0.011 Tc 9.5 0 0 9.5 525.11 254.1696 Tm (T12 )Tj -0.0167 Tc -48.238 -1.165 Td (compared )Tj -0.035 Tc 9.1158 0 0 9.5 105.21 243.0996 Tm (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.4621 0 0 9.5 113.83 243.0996 Tm (TO )Tj EMC ET BT /T1_0 1 Tf -0.018 Tc 9.5 0 0 9.5 126.89 243.0996 Tm (within )Tj -0.0258 Tc 2.686 0 Td (the )Tj -0.0182 Tc 1.412 0 Td (almitrine )Tj -0.0283 Tc 3.702 0 Td (group )Tj 0.0222 Tc 2.618 0 Td (not )Tj 0.0249 Tc 1.488 0 Td (in )Tj -0.0132 Tc 0.995 0 Td (the )Tj 0.0155 Tc 1.373 0 Td (pla)Tj 0.267 0.267 0.259 rg 0 Tc 1.231 0 Td (c)Tj 0.153 0.153 0.145 rg -0.035 Tc 9.2532 0 0 9.5 278.27 243.0996 Tm (ebo )Tj -0.0283 Tc 9.5 0 0 9.5 293.46 243.0996 Tm (group )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0252 Tc 9.5 0 0 9.5 316.7825 243.0996 Tm (\(*p<0.05, )Tj EMC /Suspect <>BDC -0.025 Tc 3.972 0 Td (**p<0.01\) )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.745 0 0 9.5 394.15 243.0996 Tm (HC0)Tj 0.326 0.326 0.318 rg 0 Tc 6.2 0 0 6.2 413.39 239.9696 Tm (3)Tj 0.529 0.505 Td (: )Tj 0.153 0.153 0.145 rg -0.0064 Tc 9.5 0 0 9.5 420.94 243.0996 Tm (plasma )Tj -0.0112 Tc 2.965 0 Td (bicarbonate)Tj 0.267 0.267 0.259 rg 0 Tc 4.541 0 Td (; )Tj 0.153 0.153 0.145 rg -0.0246 Tc 0.472 0 Td (P\(a)Tj 0.326 0.326 0.318 rg -0.035 Tc 7.9223 0 0 9.5 508.72 243.0996 Tm (-ET)Tj 0.153 0.153 0.145 rg 0.05 Tc 9.6011 0 0 9.5 520.31 243.0996 Tm (\)C0)Tj 0 Tc 6.2 0 0 6.2 535.75 239.9696 Tm (2)Tj 0.529 0.505 Td (; )Tj -0.0256 Tc 9.5 0 0 9.5 66.9 231.0596 Tm (P\(ET-a\)0)Tj 0 Tc 6.2 0 0 6.2 100.38 227.6796 Tm (2)Tj 0.524 0.545 Td (: )Tj -0.0111 Tc 9.5 0 0 9.5 109.23 231.0596 Tm (arterial )Tj -0.035 Tc 9.1158 0 0 9.5 138.2 231.0596 Tm (to )Tj -0.0019 Tc 9.5 0 0 9.5 147.99 231.0596 Tm (end )Tj -0.0247 Tc 1.758 0 Td (tidal )Tj 0.05 Tc 10.6853 0 0 9.5 183.62 231.0596 Tm (C0)Tj 0 Tc 6.2 0 0 6.2 196.46 227.6796 Tm (2 )Tj -0.0316 Tc 9.5 0 0 9.5 202.18 231.0596 Tm (and )Tj 0 Tc 1.622 0 Td (0)Tj 6.2 0 0 6.2 224.15 227.6796 Tm (2 )Tj -0.0153 Tc 9.5 0 0 9.5 229.4 231.0596 Tm (differences; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.8836 0 0 9.5 273.99 231.0596 Tm (Ppa)Tj 0.267 0.267 0.259 rg 0 Tc 9.5 0 0 9.5 289.69 231.0596 Tm (: )Tj EMC ET BT 0.153 0.153 0.145 rg /T1_0 1 Tf -0.0173 Tc 9.5 0 0 9.5 294.763 231.0596 Tm (pulmonary )Tj -0.0175 Tc 4.5 0 Td (artery )Tj -0.0182 Tc 2.518 0 Td (mean )Tj -0.0065 Tc 2.386 0 Td (pressur)Tj 0.267 0.267 0.259 rg 0 Tc 2.801 0 Td (e)Tj 0.153 0.153 0.145 rg 0.446 0 Td (; )Tj -0.0024 Tc 0.568 0 Td (Qc)Tj 0.267 0.267 0.259 rg 0 Tc 1.176 0 Td (: )Tj 0.153 0.153 0.145 rg -0.0165 Tc 0.547 0 Td (cardiac )Tj -0.0164 Tc 3.093 0 Td (output; )Tj -0.035 Tc 8.0143 0 0 9.5 495.32 231.0596 Tm (VE: )Tj -0.0185 Tc 9.5 0 0 9.5 511.12 231.0596 Tm (external )Tj -0.0166 Tc -46.783 -1.267 Td (ventilation; )Tj 0.05 Tc 10.4665 0 0 9.5 110.99 219.0196 Tm (V0)Tj 0 Tc 6.2 0 0 6.2 123.98 215.6396 Tm (2)Tj 0.563 0.545 Td (: )Tj -0.0167 Tc 9.5 0 0 9.5 131.87 219.0196 Tm (oxygen )Tj -0.0103 Tc 3.026 0 Td (uptake)Tj 0.267 0.267 0.259 rg 0 Tc 2.64 0 Td (. )Tj 0.153 0.153 0.145 rg 0.0488 Tc -12.764 -3.676 Td (observed )Tj 0 Tc 4.664 0 Td (a )Tj 0.05 Tc 10.4057 0 0 9.5 120.38 184.0996 Tm (vanatwn )Tj 9.8242 0 0 9.5 165.32 184.0996 Tm (factor )Tj 11.1664 0 0 9.5 197.59 184.0996 Tm (of )Tj 9.7509 0 0 9.5 213.18 184.0996 Tm (8.9% )Tj 9.7966 0 0 9.5 242.23 184.0996 Tm (when )Tj 9.66 0 0 9.5 271.6 184.0996 Tm (three )Tj 9.6175 0 0 9.5 64.28 173.0196 Tm (measurements )Tj 0.0389 Tc 9.5 0 0 9.5 130.98 173.0196 Tm (were )Tj 0.05 Tc 10.0137 0 0 9.5 156.98 173.0196 Tm (made )Tj 9.7232 0 0 9.5 186.37 173.0196 Tm (within )Tj 10.1218 0 0 9.5 219.76 173.0196 Tm (one )Tj 10.3422 0 0 9.5 241.75 173.0196 Tm (hour )Tj 10.0972 0 0 9.5 268.41 173.0196 Tm (in )Tj -0.035 Tc 9.1622 0 0 9.5 283.83 173.0196 Tm (18 )Tj 0.05 Tc 9.6767 0 0 9.5 64.28 162.1896 Tm (respiratory )Tj 9.7104 0 0 9.5 115.12 162.1896 Tm (patients )Tj 10.0601 0 0 9.5 152.81 162.1896 Tm (and )Tj 9.5022 0 0 9.5 173.53 162.1896 Tm (13.2% )Tj 9.7966 0 0 9.5 204.43 162.1896 Tm (when )Tj 9.7698 0 0 9.5 231.39 162.1896 Tm (three )Tj 0.0268 Tc 9.5 0 0 9.5 257.04 162.1896 Tm (series )Tj 0.05 Tc 10.8872 0 0 9.5 284.28 162.1896 Tm (of )Tj 9.5503 0 0 9.5 64.27 151.1096 Tm (three )Tj 9.6944 0 0 9.5 88.36 151.1096 Tm (measurements )Tj 0.0389 Tc 9.5 0 0 9.5 152.66 151.1096 Tm (were )Tj 0.05 Tc 9.9094 0 0 9.5 175.77 151.1096 Tm (made )Tj 9.5511 0 0 9.5 202.26 151.1096 Tm (within )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0093 Tc 9.5 0 0 9.5 233.25 151.1096 Tm (10)Tj 0.553 0.553 0.545 rg 0 Tc 0.986 0 Td (-)Tj 0.153 0.153 0.145 rg 0.0093 Tc 0.686 0 Td (12 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.886 0 0 9.5 261.9 151.1096 Tm (days )Tj 9.5033 0 0 9.5 284.79 151.1096 Tm (in )Tj -0.035 Tc 9.4317 0 0 9.5 64.93 140.0296 Tm (17 )Tj 0.05 Tc 9.6399 0 0 9.5 81.17 140.0296 Tm (patients. )Tj 10.2612 0 0 9.5 125.87 140.0296 Tm (In )Tj 9.6859 0 0 9.5 143.01 140.0296 Tm (the )Tj 9.705 0 0 9.5 163.52 140.0296 Tm (present )Tj 9.876 0 0 9.5 202.13 140.0296 Tm (study )Tj 9.5482 0 0 9.5 233.08 140.0296 Tm (we )Tj 9.7226 0 0 9.5 252.36 140.0296 Tm (used )Tj 9.6859 0 0 9.5 280.03 140.0296 Tm (the )Tj 9.6237 0 0 9.5 63.96 129.1996 Tm (correction )Tj 9.7981 0 0 9.5 112.71 129.1996 Tm (proposed )Tj 9.7211 0 0 9.5 157.98 129.1996 Tm (by )Tj -0.035 Tc 8.7632 0 0 9.5 173.77 129.1996 Tm (CHABRILLAT )Tj /T1_2 1 Tf 0.05 Tc 10.5037 0 0 9.9 231.56 129.1996 Tm (et )Tj -0.0105 Tc 9.9 0 0 9.9 244.83 129.1996 Tm (a/. )Tj /T1_0 1 Tf -0.033 Tc 9.5 0 0 9.5 260.8 129.1996 Tm ([6] )Tj 0.05 Tc 10.2172 0 0 9.5 276.82 129.1996 Tm (and )Tj 0.0431 Tc 9.5 0 0 9.5 63.96 118.3596 Tm (observed, )Tj 0.05 Tc 9.9305 0 0 9.5 107.53 118.3596 Tm (for )Tj 9.5503 0 0 9.5 123.75 118.3596 Tm (three )Tj 9.6548 0 0 9.5 147.83 118.3596 Tm (measurements, )Tj 0 Tc 9.5 0 0 9.5 214.7 118.3596 Tm (a )Tj 0.05 Tc 10.0137 0 0 9.5 222.48 118.3596 Tm (mean )Tj 0.0489 Tc 9.5 0 0 9.5 248.97 118.3596 Tm (variability )Tj 0.05 Tc 11.2967 0 0 9.5 63.94 107.2796 Tm (of9.4\2614)Tj 0.267 0.267 0.259 rg 0 Tc 9.5 0 0 9.5 103.11 107.2796 Tm (.)Tj 0.153 0.153 0.145 rg 0.05 Tc 10.5545 0 0 9.5 105.59 107.2796 Tm (3% )Tj 10.6597 0 0 9.5 123.41 107.2796 Tm (\(m\261so\). )Tj 10.0056 0 0 9.5 163.18 107.2796 Tm (The )Tj 0.0456 Tc 9.5 0 0 9.5 182.45 107.2796 Tm (initial )Tj 0.0382 Tc 2.896 0 Td (values )Tj 0.05 Tc 9.6625 0 0 9.5 239.02 107.2796 Tm (observed )Tj 9.5557 0 0 9.5 280.19 107.2796 Tm (for )Tj 9.6719 0 0 9.5 63.48 96.4496 Tm (cardiac )Tj 10.381 0 0 9.5 96.7 96.4496 Tm (output )Tj 0.0389 Tc 9.5 0 0 9.5 128.09 96.4496 Tm (were )Tj 0.05 Tc 10.0972 0 0 9.5 149.94 96.4496 Tm (in )Tj 9.8686 0 0 9.5 160.83 96.4496 Tm (the )Tj 9.7568 0 0 9.5 176.74 96.4496 Tm (range )Tj 11.4455 0 0 9.5 202.89 96.4496 Tm (of )Tj 0.0382 Tc 9.5 0 0 9.5 214.3 96.4496 Tm (values )Tj 0.05 Tc 10.0152 0 0 9.5 242.72 96.4496 Tm (reported )Tj 9.7211 0 0 9.5 282.23 96.4496 Tm (by )Tj -0.035 Tc 8.7083 0 0 9.5 63.54 85.3696 Tm (WEITZENBLUM )Tj /T1_2 1 Tf 0.05 Tc 10.1854 0 0 9.9 130.91 85.3696 Tm (et )Tj -0.0226 Tc 9.9 0 0 9.9 145.14 85.3696 Tm (a/. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0281 Tc 9.5 0 0 9.5 162.31 85.3696 Tm ([30] )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.0972 0 0 9.5 184.37 85.3696 Tm (in )Tj 0.0448 Tc 9.5 0 0 9.5 199.73 85.3696 Tm (similar )Tj 0.05 Tc 9.6399 0 0 9.5 235.28 85.3696 Tm (patients. )Tj 10.4117 0 0 9.5 278.9 85.3696 Tm (No )Tj 9.7614 0 0 9.5 317.04 184.5796 Tm (change )Tj 0.049 Tc 9.5 0 0 9.5 352.04 184.5796 Tm (was )Tj 0.05 Tc 9.6625 0 0 9.5 372.91 184.5796 Tm (observed )Tj 9.6658 0 0 9.5 416.25 184.5796 Tm (after )Tj 0.049 Tc 9.5 0 0 9.5 440.81 184.5796 Tm (almitrine. )Tj ET BT /Suspect <>BDC 0.086 0.09 0.078 rg /T1_0 1 Tf 0.05 Tc 10.0141 0 0 9.5 487.04 184.5796 Tm (Other )Tj EMC ET BT 0.153 0.153 0.145 rg /T1_0 1 Tf 0.0487 Tc 9.5 0 0 9.5 516.63 184.5796 Tm (studies )Tj 0.05 Tc 9.5057 0 0 9.5 317.28 173.4996 Tm (also )Tj 9.8126 0 0 9.5 337.5 173.4996 Tm (found )Tj 10.1226 0 0 9.5 366.25 173.4996 Tm (no )Tj 9.8402 0 0 9.5 380.13 173.4996 Tm (change )Tj 10.0972 0 0 9.5 413.62 173.4996 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.0919 0 0 9.5 425.16 173.4996 Tm (Qc )Tj EMC ET BT /T1_0 1 Tf 9.7159 0 0 9.5 440.32 173.4996 Tm (either )Tj 9.7852 0 0 9.5 468.02 173.4996 Tm (after )Tj 0 Tc 9.5 0 0 9.5 491.14 173.4996 Tm (a )Tj 0.0247 Tc 0.858 0 Td (single )Tj 0.05 Tc 9.764 0 0 9.5 526.3 173.4996 Tm (dose )Tj -0.0089 Tc 9.5 0 0 9.5 317.39 162.4296 Tm ([14, )Tj 0.0181 Tc 2.097 0 Td (23, )Tj -0.027 Tc 1.844 0 Td (31] )Tj 0.05 Tc 10.8872 0 0 9.5 371.69 162.4296 Tm (or )Tj 9.9045 0 0 9.5 385.91 162.4296 Tm (after )Tj 9.97 0 0 9.5 410.67 162.4296 Tm (short )Tj 9.8628 0 0 9.5 437.27 162.4296 Tm (term )Tj 9.8701 0 0 9.5 461.84 162.4296 Tm (therapy )Tj 0.0031 Tc 9.5 0 0 9.5 498.96 162.4296 Tm ([I )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0256 Tc 9.5 0 0 9.5 506.313 162.4296 Tm (0])Tj 0.326 0.326 0.318 rg 0 Tc 0.852 0 Td (. )Tj EMC ET BT 0.153 0.153 0.145 rg /T1_0 1 Tf 0.05 Tc 9.96 0 0 9.5 521.53 162.4296 Tm (Right )Tj 9.5912 0 0 9.5 317.12 151.3496 Tm (ventricular )Tj 0.0475 Tc 9.5 0 0 9.5 370.25 151.3496 Tm (ejection )Tj 0.05 Tc 9.6316 0 0 9.5 410.22 151.3496 Tm (fraction )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.2172 0 0 9.5 450.92 151.3496 Tm (and )Tj EMC ET BT /T1_0 1 Tf 9.9964 0 0 9.5 473.89 151.3496 Tm (heart )Tj 9.8037 0 0 9.5 502.78 151.3496 Tm (rate )Tj 0.0389 Tc 9.5 0 0 9.5 525.9 151.3496 Tm (were )Tj 0.05 Tc 9.7271 0 0 9.5 317.14 140.5096 Tm (unchanged )Tj 9.9045 0 0 9.5 368.57 140.5096 Tm (after )Tj 9.66 0 0 9.5 393.93 140.5096 Tm (three )Tj 9.9688 0 0 9.5 420.66 140.5096 Tm (months )Tj 10.8872 0 0 9.5 457.9 140.5096 Tm (of )Tj 9.8701 0 0 9.5 471.71 140.5096 Tm (therapy )Tj 0.267 0.267 0.259 rg 0 Tc 9.5 0 0 9.5 509.55 140.5096 Tm ([)Tj 0.153 0.153 0.145 rg -0.0223 Tc 0.344 0 Td (12]. )Tj 0.0493 Tc 2.061 0 Td (All )Tj 0.05 Tc 9.5266 0 0 9.5 317.11 129.4396 Tm (these )Tj 0.0362 Tc 9.5 0 0 9.5 342.8 129.4396 Tm (findings )Tj 0.05 Tc 9.9419 0 0 9.5 381.33 129.4396 Tm (are )Tj 9.6323 0 0 9.5 398.92 129.4396 Tm (consistent )Tj 9.6494 0 0 9.5 446.19 129.4396 Tm (with )Tj 9.8686 0 0 9.5 469.54 129.4396 Tm (the )Tj 0.0385 Tc 9.5 0 0 9.5 487.37 129.4396 Tm (results )Tj 0.05 Tc 11.1664 0 0 9.5 519.06 129.4396 Tm (of )Tj 9.8686 0 0 9.5 532.39 129.4396 Tm (the )Tj 9.7808 0 0 9.5 316.91 118.5996 Tm (present )Tj 0.0491 Tc 9.5 0 0 9.5 351.44 118.5996 Tm (study. )Tj 0.05 Tc 10.8219 0 0 9.5 326.93 107.7596 Tm (It )Tj 0.0345 Tc 9.5 0 0 9.5 339.93 107.7596 Tm (is )Tj 0.0236 Tc 1.318 0 Td (difficult )Tj 0.05 Tc 10.2202 0 0 9.5 390.8 107.7596 Tm (to )Tj 10.0681 0 0 9.5 405.41 107.7596 Tm (obtain )Tj 0.0462 Tc 9.5 0 0 9.5 438.73 107.7596 Tm (wedge )Tj 0.0464 Tc 3.425 0 Td (pressures )Tj 0.05 Tc 9.7748 0 0 9.5 515.79 107.7596 Tm (with )Tj 0 Tc 9.5 0 0 9.5 540.26 107.7596 Tm (a )Tj 0.05 Tc 9.5423 0 0 9.5 316.88 96.6896 Tm (microcatheter. )Tj 9.9943 0 0 9.5 382.35 96.6896 Tm (Pulmonary )Tj 9.6387 0 0 9.5 433.91 96.6896 Tm (vascular )Tj 0.0442 Tc 9.5 0 0 9.5 472.92 96.6896 Tm (resistance )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.6629 0 0 9.5 517.85 96.6896 Tm (\(PVR\) )Tj EMC ET BT /T1_0 1 Tf 9.833 0 0 9.5 316.56 85.6096 Tm (could )Tj 10.3425 0 0 9.5 345.54 85.6096 Tm (not )Tj 10.0397 0 0 9.5 364.59 85.6096 Tm (be )Tj 9.6839 0 0 9.5 379.17 85.6096 Tm (calculated)Tj 0.267 0.267 0.259 rg 0 Tc 9.5 0 0 9.5 423.13 85.6096 Tm (. )Tj 0.153 0.153 0.145 rg 0.05 Tc 9.5889 0 0 9.5 430.54 85.6096 Tm (As )Tj 10.2997 0 0 9.5 446.82 85.6096 Tm (an )Tj 9.6167 0 0 9.5 462.02 85.6096 Tm (index )Tj 11.1664 0 0 9.5 490.41 85.6096 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.8239 0 0 9.5 503.96 85.6096 Tm (PVR, )Tj EMC ET BT /T1_0 1 Tf 9.8686 0 0 9.5 532.15 85.6096 Tm (the )Tj ET endstream endobj 56 0 obj <>/Filter/JBIG2Decode/Height 3505/ImageMask true/Length 14144/Name/X/Subtype/Image/Type/XObject/Width 2480>>stream "ޒ0&9$.q N%8SwOl><};j^dFʹaQ9t< ^-aԚ{/)6R FҰX&h8RBik|Li\-jƜp?* 0>kqL+?"}K=[Oiv=y~3%{$sqȩ 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Tc 1.857 0 Td (administered )Tj 0.0203 Tc 5.715 0 Td (intravenously )Tj -0.035 Tc 9.8528 0 0 10.2 43.83 283.0696 Tm ([8, )Tj -0.0253 Tc 10.2 0 0 10.2 58.21 283.0696 Tm (23, )Tj -0.035 Tc 10.0258 0 0 10.2 74.77 283.0696 Tm (31]. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.4713 0 0 10.2 94.29 283.0696 Tm (Our )Tj EMC ET BT /T1_0 1 Tf 0.0032 Tc 10.2 0 0 10.2 115.57 283.0696 Tm (results, )Tj 0.0193 Tc 3.33 0 Td (using )Tj 0.0234 Tc 2.641 0 Td (this )Tj 0.0232 Tc 1.914 0 Td (ratio, )Tj -0.0002 Tc 2.644 0 Td (were )Tj 0.0418 Tc 2.33 0 Td (in )Tj 0.227 0.231 0.22 rg 0.0168 Tc 1.257 0 Td (the )Tj 0.153 0.153 0.141 rg 0.0051 Tc -21.161 -1.086 Td (expected )Tj 0.0162 Tc 3.927 0 Td (range. )Tj 0.0214 Tc -2.944 -1.062 Td (Symptoms )Tj 0.0218 Tc 4.874 0 Td (improved )Tj 0.05 Tc 10.3942 0 0 10.2 148.49 261.1596 Tm (in )Tj 0.0483 Tc 10.2 0 0 10.2 161.83 261.1596 Tm (both )Tj 0.0265 Tc 2.375 0 Td (groups, )Tj 0.0028 Tc 3.611 0 Td (all )Tj 0.05 Tc 10.214 0 0 10.2 238.17 261.1596 Tm (but )Tj 0.0442 Tc 10.2 0 0 10.2 256.84 261.1596 Tm (one )Tj 0.0326 Tc -20.906 -1.086 Td (patient )Tj 0.0116 Tc 3.151 0 Td (expressed )Tj 0 Tc 4.322 0 Td (a )Tj 0.0165 Tc 0.775 0 Td (sensation )Tj 0.05 Tc 11.4455 0 0 10.2 169.9 250.0796 Tm (of )Tj -0.005 Tc 10.2 0 0 10.2 181.69 250.0796 Tm (feeling )Tj 0.0289 Tc 3.058 0 Td (better )Tj 0.227 0.231 0.22 rg 0.05 Tc 10.2172 0 0 10.2 240.22 250.0796 Tm (and )Tj 0.153 0.153 0.141 rg 0.0286 Tc 10.2 0 0 10.2 259.32 250.0796 Tm (the )Tj 0.0169 Tc -21.165 -1.063 Td (same )Tj 0.0369 Tc 2.61 0 Td (number )Tj 0.05 Tc 11.1664 0 0 10.2 108.25 239.2396 Tm (of )Tj 0.0059 Tc 10.2 0 0 10.2 122.18 239.2396 Tm (subjects )Tj 0.0285 Tc 3.76 0 Td (improved )Tj 0.0212 Tc 4.563 0 Td (their )Tj 0.032 Tc 2.401 0 Td (dyspnoea )Tj -0.0011 Tc -18.443 -1.085 Td (scores. )Tj 0.0344 Tc 3.051 0 Td (The )Tj 0.0247 Tc 1.923 0 Td (purely )Tj 0.0067 Tc 2.935 0 Td (subjective )Tj 0.0444 Tc 4.404 0 Td (nature )Tj 0.05 Tc 11.1664 0 0 10.2 199.76 228.1696 Tm (of )Tj 0.0116 Tc 10.2 0 0 10.2 211.52 228.1696 Tm (such )Tj 0.0186 Tc 2.13 0 Td (improve\255)Tj 0.0441 Tc -18.644 -1.063 Td (ment )Tj -0.035 Tc 9.7912 0 0 10.2 70.23 217.3296 Tm (is )Tj 0.0266 Tc 10.2 0 0 10.2 82.02 217.3296 Tm (obvious )Tj 0.0372 Tc 3.882 0 Td (but, )Tj 0.05 Tc 10.2409 0 0 10.2 143.91 217.3296 Tm (it )Tj -0.0124 Tc 10.2 0 0 10.2 155.23 217.3296 Tm (is )Tj 0.0323 Tc 1.212 0 Td (noteworthy )Tj 0.05 Tc 10.3956 0 0 10.2 222.48 217.3296 Tm (that )Tj 0.0182 Tc 10.2 0 0 10.2 245.05 217.3296 Tm (in )Tj 0.0286 Tc 1.375 0 Td (the )Tj 0.0171 Tc -21.161 -1.086 Td (almitrine )Tj 0.0401 Tc 4.039 0 Td (group )Tj 0.0442 Tc 2.808 0 Td (one )Tj 0.0326 Tc 1.828 0 Td (patient )Tj 0.0232 Tc 3.184 0 Td (requested )Tj 0.0341 Tc (interruption )Tj 0.05 Tc 11.4455 0 0 10.2 263.09 206.2496 Tm (of )Tj 0.0127 Tc 10.2 0 0 10.2 43.01 195.1796 Tm (domiciliary )Tj 0.0211 Tc 5.414 0 Td (ventilatory )Tj 0.0166 Tc 5.209 0 Td (assistance )Tj 0.0395 Tc 4.816 0 Td (and )Tj 0.0455 Tc 2.22 0 Td (another )Tj 0.05 Tc 11.1664 0 0 10.2 263.33 195.1796 Tm (of )Tj 0.0103 Tc 10.2 0 0 10.2 43.01 184.3396 Tm (domiciliary )Tj 0.0104 Tc 5.075 0 Td (oxygen )Tj 0.0189 Tc 3.335 0 Td (therapy. )Tj 0.05 Tc 10.2612 0 0 10.2 53.15 173.2596 Tm (In )Tj 10.2281 0 0 10.2 68.53 173.2596 Tm (our )Tj 0.0314 Tc 10.2 0 0 10.2 89.43 173.2596 Tm (study )Tj -0.009 Tc 2.908 0 Td (all )Tj 0.05 Tc 10.214 0 0 10.2 135.83 173.2596 Tm (but )Tj 0.0324 Tc 10.2 0 0 10.2 155.94 173.2596 Tm (one )Tj 0.05 Tc 11.4455 0 0 10.2 177.6 173.2596 Tm (of )Tj 0.0286 Tc 10.2 0 0 10.2 192.86 173.2596 Tm (the )Tj 0.0264 Tc 1.892 0 Td (patients )Tj -0.0002 Tc 3.917 0 Td (were )Tj 0.0142 Tc -20.501 -1.085 Td (almitrine )Tj 0.0213 Tc 4.093 0 Td (responders, )Tj /T1_2 1 Tf -0.0312 Tc 5.182 0 Td (i.e. )Tj 0.227 0.231 0.22 rg /T1_0 1 Tf 0.0175 Tc 1.533 0 Td (showed )Tj 0.153 0.153 0.141 rg 0.05 Tc 10.545 0 0 10.2 188.92 162.1896 Tm (an )Tj 0.227 0.231 0.22 rg 0.0106 Tc 10.2 0 0 10.2 202.91 162.1896 Tm (increase )Tj 0.153 0.153 0.141 rg 0.05 Tc 11.1664 0 0 10.2 240.69 162.1896 Tm (of )Tj 0.0286 Tc 10.2 0 0 10.2 252.99 162.1896 Tm (over )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0095 Tc 10.2 0 0 10.2 42.7578 151.1124 Tm (0.67 )Tj EMC /Suspect <>BDC 0.0418 Tc 2.132 0 Td (kPa )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.8906 0 0 10.2 84.89 151.1096 Tm (\(5 )Tj 0.0383 Tc 10.2 0 0 10.2 97.02 151.1096 Tm (mmHg\) )Tj 0.0418 Tc 3.653 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.4918 0 0 10.2 146.36 151.1096 Tm (Pao)Tj 0 Tc 6.5001 0 0 6.5001 163.23 148.9396 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0413 Tc 10.2 0 0 10.2 171.35 151.1096 Tm (after )Tj 0.0201 Tc 2.361 0 Td (almitrine )Tj -0.035 Tc 9.6276 0 0 10.2 237.92 151.1096 Tm ([2]. )Tj 0.0462 Tc 10.2 0 0 10.2 254.92 151.1096 Tm (The )Tj 0.0359 Tc -20.816 -1.063 Td (mean )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.3398 0 0 10.2 68.82 140.2696 Tm (Pao)Tj 0 Tc 6.2 0 0 6.2 85.45 138.1096 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0173 Tc 10.2 0 0 10.2 92.38 140.2696 Tm (increase )Tj -0.0099 Tc 3.703 0 Td (\(2.4 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.039 Tc 10.2 0 0 10.2 148.7962 140.2696 Tm (kPa, )Tj EMC ET BT /T1_0 1 Tf -0.0223 Tc 10.2 0 0 10.2 171.3382 140.2696 Tm (9.3 )Tj 0.0324 Tc 1.543 0 Td (mmHg\) )Tj 0.0043 Tc 3.542 0 Td (was )Tj 0.0181 Tc 1.875 0 Td (similar )Tj 0.05 Tc 10.5122 0 0 10.2 42.6 129.4396 Tm (to )Tj 10.2491 0 0 10.2 55.36 129.4396 Tm (that )Tj 0.0204 Tc 10.2 0 0 10.2 76 129.4396 Tm (observed )Tj 0.0182 Tc 4.109 0 Td (in )Tj 0.0099 Tc 1.198 0 Td (studies )Tj 0.0165 Tc 3.2 0 Td (where )Tj 0.0201 Tc 2.895 0 Td (almitrine )Tj 0.0019 Tc 4.142 0 Td (bismesy\255)Tj 0.0209 Tc -18.825 -1.086 Td (late )Tj -0.0075 Tc 1.895 0 Td (was )Tj 0.0035 Tc 1.953 0 Td (given )Tj 0.0183 Tc 2.644 0 Td (intravenously )Tj -0.028 Tc 6.098 0 Td ([19, )Tj -0.035 Tc 10.0672 0 0 10.2 190.66 118.3596 Tm (26]. )Tj 0.0115 Tc 10.2 0 0 10.2 210.28 118.3596 Tm (Similar )Tj 0.0101 Tc 3.392 0 Td (values )Tj -0.0002 Tc -19.854 -1.063 Td (were )Tj 0.0258 Tc 2.469 0 Td (found )Tj 0.0418 Tc 3.025 0 Td (in )Tj 0 Tc 1.368 0 Td (a )Tj 0.0283 Tc 1.011 0 Td (short-term )Tj 0.0373 Tc 4.958 0 Td (study )Tj 0.0106 Tc 2.823 0 Td (where )Tj 0.023 Tc 3.013 0 Td (almitrine )Tj 0.0063 Tc -18.663 -1.085 Td (bismesylate )Tj 0.0279 Tc 5.121 0 Td (was )Tj -0.0024 Tc 1.953 0 Td (given )Tj 0.015 Tc 2.572 0 Td (orally )Tj 0.0418 Tc 2.74 0 Td (in )Tj 0.227 0.231 0.22 rg 0 Tc 1.155 0 Td (a )Tj 0.153 0.153 0.141 rg 0.0236 Tc 0.851 0 Td (larger )Tj 0.0165 Tc 2.762 0 Td (daily )Tj 0.0228 Tc 2.408 0 Td (dosage )Tj -0.035 Tc 9.8225 0 0 10.2 42.39 85.3696 Tm ([25]. )Tj 0.0144 Tc 10.2 0 0 10.2 67.14 85.3696 Tm (Finally, )Tj 0.0286 Tc 3.897 0 Td (the )Tj 0.0204 Tc 1.94 0 Td (present )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.3398 0 0 10.2 163.94 85.3696 Tm (Pao)Tj 0 Tc 6.5001 0 0 6.5001 181.05 83.1996 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0261 Tc 10.2 0 0 10.2 191.59 85.3696 Tm (improvement )Tj 0.0043 Tc 6.24 0 Td (was )Tj 0.0315 Tc 4.072 22.617 Td (superior )Tj 0.05 Tc 10.2202 0 0 10.2 336.38 316.0596 Tm (to )Tj 0.0448 Tc 10.2 0 0 10.2 349.38 316.0596 Tm (that )Tj 0.017 Tc 2.047 0 Td (observed )Tj 0.227 0.231 0.22 rg 0.0295 Tc 4.13 0 Td (after )Tj 0 Tc 2.361 0 Td (a )Tj 0.153 0.153 0.141 rg -0.0047 Tc 0.87 0 Td (single )Tj 0.0219 Tc 2.767 0 Td (dose )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.6284 0 0 10.2 497.03 316.0596 Tm ([20] )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.6081 0 0 10.2 516.42 316.0596 Tm (or )Tj 0.0295 Tc 10.2 0 0 10.2 296.56 305.2196 Tm (after )Tj 0.0218 Tc 2.381 0 Td (six-month )Tj 0.0322 Tc 4.685 0 Td (therapy )Tj 0.0418 Tc 3.607 0 Td (in )Tj 0 Tc 1.273 0 Td (a )Tj 0.0124 Tc 0.899 0 Td (large )Tj 0.0401 Tc 2.478 0 Td (group )Tj 0.05 Tc 11.4455 0 0 10.2 482.7 305.2196 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.2293 0 0 10.2 496.19 305.2196 Tm (COLD )Tj EMC ET BT /T1_0 1 Tf 0.0297 Tc 10.2 0 0 10.2 296.44 294.1496 Tm (patients )Tj 0.0047 Tc 3.775 0 Td ([I]. )Tj 0.0226 Tc 1.763 0 Td (The )Tj 0.0336 Tc 2.087 0 Td (better )Tj 0.05 Tc 10.3147 0 0 10.2 403.8 294.1496 Tm (than )Tj 0.0116 Tc 10.2 0 0 10.2 428.04 294.1496 Tm (average )Tj 0.0139 Tc 3.645 0 Td (results )Tj -0.029 Tc 3.179 0 Td (in )Tj 0.0156 Tc 1.234 0 Td (this )Tj 0.0255 Tc -20.953 -1.063 Td (study )Tj 0.0453 Tc 2.696 0 Td (are )Tj 0.0076 Tc 1.734 0 Td (possibly )Tj 0.0385 Tc 3.79 0 Td (due )Tj 0.028 Tc 1.967 0 Td (to )Tj 0.0165 Tc 1.269 0 Td (longer )Tj 0.0124 Tc 3.043 0 Td (follow-up )Tj 0.05 Tc 10.6081 0 0 10.2 490.41 283.3096 Tm (or )Tj 0.0254 Tc 10.2 0 0 10.2 503.74 283.3096 Tm (more )Tj 0.0186 Tc -20.316 -1.11 Td (suitable )Tj 0.0264 Tc 3.652 0 Td (patients )Tj 0.0265 Tc 3.656 0 Td (who )Tj 0.0076 Tc 2.196 0 Td (were )Tj -0.0091 Tc 2.351 0 Td (exclusively )Tj 0.0484 Tc 4.852 0 Td (pure )Tj 0.0207 Tc 2.303 0 Td (obstruc\255)Tj -0.0024 Tc -19.022 -1.062 Td (tive )Tj 0.05 Tc 10.3744 0 0 10.2 315.1 261.1596 Tm (and )Tj 10.2553 0 0 10.2 334.94 261.1596 Tm (non)Tj 0.337 0.341 0.329 rg 0 Tc 10.2 0 0 10.2 351.69 261.1596 Tm (-)Tj 0.227 0.231 0.22 rg 0.0179 Tc 0.332 0 Td (asthmatic. )Tj 0.153 0.153 0.141 rg 0.05 Tc 10.2612 0 0 10.2 306.47 250.3196 Tm (In )Tj 0.227 0.231 0.22 rg 0.0077 Tc 10.2 0 0 10.2 319.28 250.3196 Tm (this )Tj 0.0196 Tc 1.806 0 Td (study)Tj 0.337 0.341 0.329 rg 0 Tc (, )Tj 0.153 0.153 0.141 rg -0.0274 Tc 2.823 0 Td (we )Tj 0.0136 Tc 1.478 0 Td (observed )Tj 0.227 0.231 0.22 rg 0 Tc 4.037 0 Td (a )Tj 0.153 0.153 0.141 rg 0.0002 Tc 0.822 0 Td (slight )Tj 0.05 Tc 10.3901 0 0 10.2 457.06 250.3196 Tm (but )Tj 0.0004 Tc 10.2 0 0 10.2 474.54 250.3196 Tm (insignificant )Tj 0.0038 Tc -17.494 -1.086 Td (increase )Tj 0.227 0.231 0.22 rg 0.0182 Tc 3.66 0 Td (in )Tj 0.0059 Tc 1.163 0 Td (ventilation. )Tj 0.153 0.153 0.141 rg 0.0044 Tc 4.981 0 Td (As )Tj 0.0018 Tc 1.491 0 Td (previously )Tj 0.0082 Tc 4.568 0 Td (emphasized )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.0154 0 0 10.2 510.26 239.2396 Tm ([20, )Tj EMC ET BT /T1_0 1 Tf 9.9022 0 0 10.2 296.37 228.4096 Tm (26], )Tj 0.0168 Tc 10.2 0 0 10.2 319.28 228.4096 Tm (the )Tj 0.0143 Tc 2.048 0 Td (improvement )Tj 0.0182 Tc 6.209 0 Td (in )Tj 0.0175 Tc 1.615 0 Td (blood )Tj -0.0094 Tc 3.13 0 Td (gas )Tj 0.0006 Tc 2.084 0 Td (values )Tj 0.0154 Tc 3.281 0 Td (with )Tj 0.0142 Tc -20.642 -1.086 Td (almitrine )Tj -0.0007 Tc 3.977 0 Td (bismesylate )Tj 0.0427 Tc 4.947 0 Td (cannot )Tj 0.0109 Tc 3.127 0 Td (be )Tj 0.0149 Tc 1.193 0 Td (due )Tj -0.0094 Tc 1.742 0 Td (solely )Tj 0.028 Tc 2.609 0 Td (to )Tj 0.0028 Tc 1.08 0 Td (increased )Tj 0.0102 Tc -18.691 -1.086 Td (ventilation. )Tj 0.0016 Tc 5.096 0 Td (Previous )Tj 0.0099 Tc 3.91 0 Td (studies )Tj 0.0022 Tc 3.234 0 Td (showing )Tj 0.0168 Tc 3.766 0 Td (the )Tj 0.0054 Tc 1.645 0 Td (discrepancy )Tj 0.0017 Tc -17.625 -1.062 Td (between )Tj 0.0175 Tc 4.084 0 Td (blood )Tj 0.0024 Tc 3.083 0 Td (gas )Tj 0.0098 Tc 2.077 0 Td (improvements )Tj 0.0395 Tc 6.561 0 Td (and )Tj 0.0078 Tc 2.275 0 Td (ventilation )Tj 0.0061 Tc -18.115 -1.086 Td (changes )Tj -0.0036 Tc 4.032 0 Td (suggest )Tj 0.05 Tc 10.2491 0 0 10.2 375.15 184.3396 Tm (that )Tj 0.227 0.231 0.22 rg 0.0112 Tc 10.2 0 0 10.2 399.63 184.3396 Tm (almitrine )Tj 0.153 0.153 0.141 rg -0.0007 Tc 4.474 0 Td (bismesylate )Tj 0.0145 Tc 5.45 0 Td (might )Tj 0.0182 Tc -20.121 -1.086 Td (improve )Tj 0.227 0.231 0.22 rg 0.011 Tc 4.162 0 Td (ventilation-perfusion )Tj 0.153 0.153 0.141 rg 0.0093 Tc 9.277 0 Td (matching. )Tj 0.0073 Tc 4.811 0 Td (Indeed, )Tj 0.227 0.231 0.22 rg 0 Tc 3.751 0 Td (a )Tj 0.153 0.153 0.141 rg 0.0182 Tc -21.971 -1.062 Td (redistribution )Tj 0.05 Tc 10.6081 0 0 10.2 356.29 162.4296 Tm (of )Tj 0.0293 Tc 10.2 0 0 10.2 367.48 162.4296 Tm (blood )Tj -0.0347 Tc 2.678 0 Td (flow )Tj 0.0324 Tc 2.04 0 Td (has )Tj 0.0041 Tc 1.655 0 Td (been )Tj 0.0202 Tc 2.185 0 Td (demonstrated )Tj -0.035 Tc 9.6065 0 0 10.2 514.85 162.4296 Tm ([4, )Tj 9.9919 0 0 10.2 296.32 151.3496 Tm (14, )Tj 10.0672 0 0 10.2 310.82 151.3496 Tm (22]. )Tj 0.0462 Tc 10.2 0 0 10.2 328.85 151.3496 Tm (The )Tj 0.0145 Tc 1.92 0 Td (redistribution )Tj 0.227 0.231 0.22 rg 0.05 Tc 11.4455 0 0 10.2 408.29 151.3496 Tm (of )Tj 0.153 0.153 0.141 rg 0.0108 Tc 10.2 0 0 10.2 419.87 151.3496 Tm (lung )Tj 0.0132 Tc 2.065 0 Td (perfusion )Tj -0.0115 Tc 4.163 0 Td (suggests )Tj 0 Tc 3.592 0 Td (a )Tj 0.011 Tc -21.994 -1.086 Td (vascular )Tj -0.0113 Tc 4.052 0 Td (effect )Tj 0.05 Tc 10.8872 0 0 10.2 365.92 140.2696 Tm (of )Tj 0.0142 Tc 10.2 0 0 10.2 381.33 140.2696 Tm (almitrine )Tj -0.0031 Tc 4.378 0 Td (bismesylate )Tj 0.0147 Tc 5.36 0 Td (perhaps )Tj 0 Tc 3.86 0 Td (a )Tj 0.0094 Tc -21.991 -1.062 Td (precapillary )Tj 0.0108 Tc 5.497 0 Td (vasoconstriction)Tj 0.337 0.341 0.329 rg 0 Tc 6.78 0 Td (. )Tj ET BT /Suspect <>BDC 0.153 0.153 0.141 rg /T1_0 1 Tf 0.0062 Tc 10.2 0 0 10.2 429.4026 129.4372 Tm (Such )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.2997 0 0 10.2 455.98 129.4396 Tm (an )Tj -0.0161 Tc 10.2 0 0 10.2 472.35 129.4396 Tm (effect )Tj 0.0086 Tc 2.771 0 Td (might )Tj 0.0053 Tc -20.122 -1.063 Td (cause )Tj 0 Tc 2.573 0 Td (a )Tj -0.0084 Tc 0.835 0 Td (rise )Tj -0.0054 Tc 1.764 0 Td (in )Tj 0.0235 Tc 1.119 0 Td (pulmonary )Tj 0.0161 Tc 4.852 0 Td (arterial )Tj -0.0008 Tc 3.293 0 Td (pressure. )Tj 0.05 Tc 10.5385 0 0 10.2 305.5 107.5196 Tm (In )Tj 0.0272 Tc 10.2 0 0 10.2 317.27 107.5196 Tm (animals )Tj -0.035 Tc 9.6284 0 0 10.2 353.27 107.5196 Tm ([23] )Tj 0.05 Tc 10.3744 0 0 10.2 370.97 107.5196 Tm (and )Tj 0.039 Tc 10.2 0 0 10.2 389.61 107.5196 Tm (normal )Tj 0.0093 Tc 3.292 0 Td (subjects )Tj -0.035 Tc 9.8164 0 0 10.2 458.97 107.5196 Tm ([8], )Tj 0.0241 Tc 10.2 0 0 10.2 474.54 107.5196 Tm (intravenous )Tj 0.227 0.231 0.22 rg 0.026 Tc -17.567 -1.085 Td (almitrine )Tj 0.153 0.153 0.141 rg 0.0111 Tc 4.048 0 Td (bismesylate )Tj 0.0162 Tc 5.041 0 Td (causes )Tj 0.05 Tc 10.2997 0 0 10.2 417.93 96.4496 Tm (an )Tj 0.0106 Tc 10.2 0 0 10.2 430.71 96.4496 Tm (increase )Tj 0.0418 Tc 3.565 0 Td (in )Tj 0.0324 Tc 1.073 0 Td (pulmonary )Tj 0.0275 Tc -17.907 -1.063 Td (artery )Tj 0.0213 Tc 3.08 0 Td (pressure)Tj 0.337 0.341 0.329 rg 0 Tc 3.52 0 Td (. )Tj 0.153 0.153 0.141 rg 0.0312 Tc 0.842 0 Td (Haemodynamic )Tj 0.0099 Tc 7.285 0 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0.118 0.106 rg 0.598 0 Td (I)Tj 0.247 0.247 0.235 rg -0.035 Tc 9.3843 0 0 10.4 291.19 762.48 Tm (SMESYLATB )Tj EMC ET BT /T1_0 1 Tf 9.75 0 0 10.4 348.4 762.48 Tm (THERAPY )Tj 0.0258 Tc 9.5 0 0 9.5 539 762.48 Tm (47 )Tj /T1_1 1 Tf -0.0084 Tc 9 0 0 9 70.02 739.44 Tm (Table )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 9.7551 0 0 9 95.73 739.44 Tm (Ill.-)Tj EMC /Suspect <>BDC -0.0009 Tc 9 0 0 9 118.79 738.97 Tm (Individual )Tj EMC ET BT /T1_1 1 Tf 0.009 Tc 9 0 0 9 159.164 738.97 Tm (Ppa )Tj -0.0006 Tc 2.046 0 Td (values )Tj 0.537 0.541 0.525 rg 0 Tc 7.7 0 0 7.7 199.61 724.09 Tm (-)Tj ET BT /Suspect <>BDC 0.247 0.247 0.235 rg /T1_0 1 Tf 0.0402 Tc 8.9 0 0 8.9 200.6 716.89 Tm (Ppa )Tj EMC ET BT /T1_0 1 Tf 0.033 Tc 8.9 0 0 8.9 220.7763 716.89 Tm (kPa )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.2465 0 0 8.9 154.97 706.33 Tm (TO )Tj EMC ET BT /T1_0 1 Tf 0.039 Tc 8.9 0 0 8.9 212.08 706.33 Tm (T6 )Tj 0.0392 Tc 6.364 0 Td (T12 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 155.3959 684.7297 Tm (5)Tj 0.372 0.372 0.361 rg 0.587 0 Td (.)Tj 0.247 0.247 0.235 rg 0.0463 Tc 0.172 0 Td (00 )Tj EMC /Suspect <>BDC 0.0402 Tc 5.608 0 Td (3.20 )Tj EMC /Suspect <>BDC 0.033 Tc 6.371 0 Td (4.04 )Tj EMC ET BT /T1_0 1 Tf 0.0075 Tc 8.9 0 0 8.9 70.0627 673.6759 Tm (Almitrine )Tj -0.0018 Tc 9.597 0 Td (2.27 )Tj 0.0342 Tc 6.364 0 Td (2.12 )Tj -0.0018 Tc 6.418 0 Td (2.29 )Tj 0.0149 Tc -22.429 -1.187 Td (bismesylate )Tj 0.0402 Tc 9.588 0 Td (3.12 )Tj 0 Tc 6.424 -0.053 Td (2)Tj 0.114 0.118 0.106 rg 0.579 0 Td (.)Tj 0.247 0.247 0.235 rg 0.0059 Tc 0.218 0 Td (86 )Tj 0.0162 Tc 5.567 0 Td (2.76 )Tj 0.0137 Tc -22.384 -1.187 Td (group )Tj 0.0162 Tc 9.602 0 Td (2.23 )Tj 0.0042 Tc 6.412 0 Td (3.33 )Tj -0.0018 Tc 6.37 0 Td (2.21 )Tj 0.0138 Tc -22.388 -1.187 Td (\(n=8\) )Tj 0.0157 Tc 9.63 -0.054 Td (1.96 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0162 Tc 8.9 0 0 8.9 212.1156 641.0307 Tm (2.09 )Tj EMC ET BT /T1_0 1 Tf -0.0018 Tc 8.9 0 0 8.9 268.7552 641.0307 Tm (2.83 )Tj 0.0162 Tc -12.782 -1.188 Td [(2.69 )-4337(2.77 )]TJ -0.0018 Tc 12.782 0 Td (2.83 )Tj 0.0157 Tc -12.757 -1.24 Td (1.49 )Tj -0.0202 Tc 6.472 0 Td (1.87 )Tj 0.0157 Tc 6.31 0 Td (1.97 )Tj -12.782 -1.239 Td (1.49 )Tj 8.9 0 0 8.9 212.08 706.33 Tm 0.029 -11.004 Td (1.52 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.9 0 0 8.9 268.9777 608.3944 Tm (1.40 )Tj EMC /Suspect <>BDC -0.035 Tc 8.9234 0 0 11.3 68.63 597.36 Tm (X\261sEM )Tj EMC /Suspect <>BDC -0.0018 Tc 8.9 0 0 8.9 136.27 597.36 Tm (2.53 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 154.07 597.36 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0171 Tc 8.9 0 0 8.9 161.6706 597.36 Tm (0.40 )Tj EMC ET BT /T1_0 1 Tf 0.0162 Tc 8.9 0 0 8.9 190.9872 597.36 Tm (2.47 )Tj 0 Tc 2 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0009 Tc 8.9 0 0 8.9 216.3878 597.36 Tm (0.23 )Tj EMC ET BT /T1_0 1 Tf 0.0342 Tc 8.9 0 0 8.9 252.4239 597.36 Tm (2.54)Tj 0.372 0.372 0.361 rg 0 Tc 2 0 Td (\261 )Tj ET BT /Suspect <>BDC 0.247 0.247 0.235 rg /T1_0 1 Tf -0.0009 Tc 8.9 0 0 8.9 277.8245 597.36 Tm (0.28 )Tj EMC ET BT /T1_0 1 Tf 0.0342 Tc 8.9 0 0 8.9 154.5061 575.7597 Tm (2.24 )Tj -0.0202 Tc 6.497 0 Td (1.87 )Tj -0.0018 Tc 6.285 -0.053 Td (2.31 )Tj 0.0059 Tc -22.381 -1.133 Td (Placebo )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0157 Tc 8.9 0 0 8.9 154.7286 564.7237 Tm (1.70 )Tj EMC ET BT /T1_0 1 Tf 0.0162 Tc 8.9 0 0 8.9 211.6263 564.7237 Tm (2.16 )Tj -0.0022 Tc 6.443 0 Td (1.36 )Tj 0.0137 Tc -22.517 -1.242 Td (group )Tj -0.0022 Tc 9.681 0 Td (1.47 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0157 Tc 8.9 0 0 8.9 211.8488 553.6699 Tm (1.20 )Tj EMC ET BT /T1_0 1 Tf -0.0202 Tc 8.9 0 0 8.9 268.969 553.6699 Tm (1.33 )Tj 0.0138 Tc -22.52 -1.239 Td (\(n=7\) )Tj 0.0157 Tc 9.684 0 Td (1.72 )Tj -0.0022 Tc 6.418 0 Td (1.55 )Tj -0.0202 Tc 6.418 0 Td (1.33 )Tj 0.0162 Tc -12.915 -1.24 Td (2.15 )Tj -0.0022 Tc 6.497 0 Td (1.45 )Tj -0.0202 Tc 6.364 0 Td (1.41 )Tj -12.782 -1.242 Td (1.93 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0162 Tc 8.9 0 0 8.9 211.1457 520.553 Tm (2.00 )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 8.7654 0 0 9.2 268.52 520.56 Tm (1.92 )Tj /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 154.03 509.53 Tm (2)Tj 0.372 0.372 0.361 rg 0.579 0 Td (.)Tj 0.247 0.247 0.235 rg 0.0496 Tc 0.171 0 Td (99 )Tj -0.0018 Tc 5.669 0 Td (2.18 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0342 Tc 8.9 0 0 8.9 267.7987 509.53 Tm (2.40 )Tj EMC /Suspect <>BDC 0.05 Tc 9.0314 0 0 8.9 67.17 498.49 Tm (x\261SEM )Tj EMC /Suspect <>BDC -0.0018 Tc 8.9 0 0 8.9 135.31 498.49 Tm (2.03 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 153.11 498.49 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0171 Tc 8.9 0 0 8.9 160.7106 498.49 Tm (0.19 )Tj EMC ET BT /T1_0 1 Tf -0.0022 Tc 8.9 0 0 8.9 193.6139 498.49 Tm (1.77 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.4392 0 0 8.9 210.71 498.49 Tm (\2610.14 )Tj EMC ET BT /T1_0 1 Tf -0.0022 Tc 8.9 0 0 8.9 253.61 498.49 Tm (1.72 )Tj 0.372 0.372 0.361 rg 0 Tc 1.921 0 Td (\261 )Tj ET BT /Suspect <>BDC 0.247 0.247 0.235 rg /T1_0 1 Tf -0.0009 Tc 8.9 0 0 8.9 278.3075 498.49 Tm (0.18 )Tj EMC ET BT /T1_0 1 Tf 0.0127 Tc 8.9 0 0 8.9 67.6178 476.8897 Tm (Individual )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0402 Tc 8.9 0 0 8.9 109.3944 476.8897 Tm (Ppa )Tj EMC ET BT 0.176 0.176 0.165 rg /T1_0 1 Tf 0.0192 Tc 8.9 0 0 8.9 127.6572 476.8897 Tm (values )Tj 0.247 0.247 0.235 rg 0.0247 Tc 2.913 0 Td (recorded )Tj 0.0461 Tc 4.09 0 Td (at )Tj 0.176 0.176 0.165 rg 0.0441 Tc 0.971 0 Td (each )Tj 0.247 0.247 0.235 rg 0.0181 Tc 2.111 0 Td (measurement )Tj 0.0027 Tc 5.717 0 Td (time )Tj /T1_1 1 Tf 0.05 Tc 9.14 0 0 8.8 286.38 476.89 Tm (in )Tj /T1_0 1 Tf 0.0093 Tc 8.9 0 0 8.9 68.07 465.84 Tm (almitrine )Tj 0.0149 Tc 3.894 0 Td (bismesylate )Tj 0.0121 Tc 5.112 0 Td (and )Tj 0.0232 Tc 1.683 0 Td (placebo )Tj 0.0015 Tc 3.443 0 Td (groups. )Tj 0.0191 Tc 10.4 0 0 10.4 67.22 422.65 Tm (patients )Tj -0.0321 Tc 3.589 0 Td (given )Tj 0 Tc 2.49 0 Td (a )Tj -0.0085 Tc 0.781 0 Td (sing)Tj 0.114 0.118 0.106 rg 0 Tc 1.667 0 Td (l)Tj 0.247 0.247 0.235 rg 0.229 0 Td (e )Tj 0.009 Tc 0.74 0 Td (infusion )Tj 0.05 Tc 11.1292 0 0 10.4 204.37 422.65 Tm (of )Tj 0.0067 Tc 10.4 0 0 10.4 216.85 422.65 Tm (almitrine )Tj -0.0196 Tc 4.027 0 Td (bismesy\255)Tj 0.176 0.176 0.165 rg 0.002 Tc -18.379 -1.015 Td (late )Tj 0.247 0.247 0.235 rg 0.0191 Tc 2.075 0 Td (are )Tj 0.0164 Tc 1.847 0 Td (contradictory. )Tj 0.0221 Tc 6.453 0 Td (Some )Tj 0.0032 Tc 2.912 0 Td (studies )Tj 0.019 Tc 3.475 0 Td (reported )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 11.243 0 0 10.4 284.52 412.09 Tm (an )Tj EMC ET BT 0.176 0.176 0.165 rg /T1_0 1 Tf -0.0034 Tc 10.4 0 0 10.4 67.59 401.05 Tm (increase )Tj 0.247 0.247 0.235 rg -0.0224 Tc 3.508 0 Td (in )Tj ET BT /Suspect <>BDC 0.176 0.176 0.165 rg /T1_0 1 Tf 0.0197 Tc 10.4 0 0 10.4 115.1492 401.05 Tm (Ppa )Tj EMC ET BT 0.247 0.247 0.235 rg /T1_0 1 Tf -0.0016 Tc 10.4 0 0 10.4 134.2956 401.05 Tm (due )Tj -0.035 Tc 10.3833 0 0 10.4 153.09 401.05 Tm (to )Tj 0.05 Tc 10.7542 0 0 10.4 164.05 401.05 Tm (an )Tj 0.0032 Tc 10.4 0 0 10.4 177.51 401.05 Tm (increase )Tj 0.0238 Tc 3.554 0 Td (in )Tj 0.0245 Tc 1.023 0 Td (right )Tj 0.0156 Tc 2.261 0 Td (ventricular )Tj 0.0069 Tc -17.442 -1.062 Td (pressure )Tj 0.0227 Tc 3.782 0 Td (without )Tj 0.0105 Tc 3.591 0 Td (change )Tj -0.0224 Tc 3.324 0 Td (in )Tj 0.023 Tc 1.199 0 Td (cardiac )Tj 0.0379 Tc 3.415 0 Td (output )Tj -0.035 Tc 9.982 0 0 10.4 259.92 390 Tm ([15, )Tj 8.7922 0 0 10.4 279.74 390 Tm (31 )Tj 0 Tc 10.4 0 0 10.4 288.85 390 Tm (])Tj 0.372 0.372 0.361 rg 0.364 0 Td (, )Tj 0.247 0.247 0.235 rg 0.0226 Tc -21.687 -1.061 Td (other )Tj 0.0032 Tc 2.487 0 Td (studies )Tj -0.0048 Tc 3.189 0 Td (observed )Tj 0.0187 Tc 3.978 0 Td (no )Tj 0.0105 Tc 1.376 0 Td (change )Tj -0.035 Tc 10.3148 0 0 10.4 215.27 378.97 Tm ([24, )Tj 9.6456 0 0 10.4 234.66 378.97 Tm (28])Tj 0.372 0.372 0.361 rg 0 Tc 10.4 0 0 10.4 247.94 378.97 Tm (. )Tj ET BT /Suspect <>BDC 0.247 0.247 0.235 rg /T1_0 1 Tf -0.0078 Tc 10.4 0 0 10.4 253.8784 378.97 Tm (WEit)Tj 0.372 0.372 0.361 rg 0 Tc 2.078 0 Td (Z)Tj 0.247 0.247 0.235 rg -0.035 Tc 8.4948 0 0 10.4 281.23 378.97 Tm (EN\255)Tj EMC ET BT /T1_0 1 Tf 8.3467 0 0 10.4 66.68 368.41 Tm (BLUM )Tj /T1_2 1 Tf 0.0357 Tc 9.7 0 0 9.7 95.91 368.41 Tm (et )Tj 0.05 Tc 9.9734 0 0 9.7 109.37 368.41 Tm (a/)Tj 0.114 0.118 0.106 rg 0 Tc 9.7 0 0 9.7 117.51 368.41 Tm (. )Tj 0.247 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 9.7536 0 0 10.4 126 368.41 Tm ([31] )Tj 0.0075 Tc 10.4 0 0 10.4 147.25 368.41 Tm (explained )Tj -0.0047 Tc 4.577 0 Td (these )Tj -0.0014 Tc 2.624 0 Td (discrepancies )Tj -0.0212 Tc 6.011 0 Td (by )Tj -0.0182 Tc -20.918 -1.062 Td (differences )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.6555 0 0 10.4 113.67 357.37 Tm (in )Tj EMC ET BT /T1_0 1 Tf 0.0191 Tc 10.4 0 0 10.4 124.82 357.37 Tm (patients )Tj 0.0225 Tc 3.495 0 Td (and )Tj 0.0133 Tc 1.809 0 Td (methods )Tj 0.0355 Tc 3.741 0 Td (but )Tj 0.0018 Tc 1.605 0 Td (observed )Tj -0.0213 Tc 3.932 0 Td (with )Tj -0.0065 Tc -20.131 -1.062 Td (identical )Tj 0.0256 Tc 3.93 0 Td (methodo)Tj 0.114 0.118 0.106 rg 0 Tc 3.686 0 Td (l)Tj 0.247 0.247 0.235 rg -0.0227 Tc 0.276 0 Td (ogy, )Tj -0.0089 Tc 2.261 0 Td (an )Tj 0.0136 Tc 1.477 0 Td (early )Tj 0.0456 Tc 2.538 0 Td (and )Tj 0.021 Tc 2.085 0 Td (transitory )Tj -0.0162 Tc 4.563 0 Td (in\255)Tj -0.0056 Tc -20.863 -1.062 Td (crease )Tj -0.035 Tc 9.9195 0 0 10.4 100.72 335.28 Tm (in )Tj ET BT /Suspect <>BDC 0.176 0.176 0.165 rg /T1_0 1 Tf 0.0067 Tc 10.4 0 0 10.4 116.59 335.28 Tm (Ppa. )Tj EMC ET BT 0.247 0.247 0.235 rg /T1_0 1 Tf 0.0168 Tc 10.4 0 0 10.4 143.9836 335.28 Tm (After )Tj 0.043 Tc 2.9 0 Td (oral )Tj 0.0067 Tc 2.445 0 Td (almitrine )Tj -0.0044 Tc 4.488 0 Td (bismesylate )Tj 0.0225 Tc -17.273 -1.061 Td (adm)Tj 0.114 0.118 0.106 rg 0 Tc 1.802 0 Td (i)Tj 0.247 0.247 0.235 rg 0.0124 Tc 0.285 0 Td (nist)Tj 0.114 0.118 0.106 rg 0 Tc 1.477 0 Td (r)Tj 0.247 0.247 0.235 rg 0.0295 Tc 0.36 0 Td (at)Tj 0.114 0.118 0.106 rg -0.0224 Tc 0.787 0 Td (io)Tj 0.247 0.247 0.235 rg -0.0082 Tc 0.792 0 Td (n, )Tj 0 Tc 1.237 0 Td (a )Tj 0.176 0.176 0.165 rg 0.93 0 Td (4 )Tj 0.247 0.247 0.235 rg 0.03 Tc 0.925 0 Td (mmHg )Tj 0.114 0.118 0.106 rg -0.0224 Tc 3.316 0 Td (in)Tj 0.247 0.247 0.235 rg -0.0078 Tc 0.784 0 Td (crease, )Tj 0 Tc 3.188 0 Td (2 )Tj 0.01 Tc 0.972 0 Td (to )Tj 0 Tc 1.284 0 Td [(3 )-184(h )]TJ 0.0186 Tc 1.893 0 Td (after )Tj -0.0006 Tc -20.031 -1.015 Td (adm)Tj 0.114 0.118 0.106 rg 0 Tc 1.802 0 Td (i)Tj 0.247 0.247 0.235 rg 0.0134 Tc 0.285 0 Td (nistration, )Tj -0.0179 Tc 4.569 0 Td (has )Tj -0.0255 Tc 1.71 0 Td (been )Tj 0.0018 Tc 2.159 0 Td (observed )Tj 0 Tc 4.001 0 Td ([)Tj 0.114 0.118 0.106 rg 0.312 0 Td (1)Tj 0.247 0.247 0.235 rg 0.4 0 Td (4)Tj 0.372 0.372 0.361 rg 0.542 0 Td (, )Tj 0.247 0.247 0.235 rg -0.035 Tc 10.1981 0 0 10.4 236.1 313.69 Tm (27]. )Tj 0.176 0.176 0.165 rg 0.0315 Tc 10.4 0 0 10.4 76.23 302.65 Tm (Thus)Tj 0.372 0.372 0.361 rg 0 Tc 2.116 0 Td (, )Tj 0.247 0.247 0.235 rg 0.0093 Tc 0.889 0 Td (there )Tj -0.035 Tc 9.3682 0 0 10.4 136.24 302.65 Tm (is )Tj 10.2675 0 0 10.4 149.17 302.65 Tm (ev)Tj 0.114 0.118 0.106 rg 0 Tc 10.4 0 0 10.4 158.79 302.65 Tm (i)Tj 0.247 0.247 0.235 rg 0.0085 Tc 0.23 0 Td (dence )Tj 0.0402 Tc 3.053 0 Td (that )Tj 0 Tc 2.3 0 Td (a )Tj -0.0106 Tc 1.104 0 Td (single )Tj 0.0077 Tc 3.005 0 Td (dose )Tj 0.05 Tc 11.1292 0 0 10.4 285.97 302.65 Tm (of )Tj 0.176 0.176 0.165 rg 0.0067 Tc 10.4 0 0 10.4 66.61 291.61 Tm (almitrine )Tj 0.247 0.247 0.235 rg -0.0044 Tc 4.304 0 Td (bismesylate )Tj 0.0324 Tc 5.251 0 Td (can )Tj 0.006 Tc 2.078 0 Td (induce )Tj 0.0112 Tc 3.284 0 Td (vasoconstrict)Tj 0.114 0.118 0.106 rg 0 Tc 5.439 0 Td (i)Tj 0.247 0.247 0.235 rg 0.0083 Tc 0.23 0 Td (on. )Tj 0.0095 Tc -20.627 -1.062 Td (Like )Tj -0.0088 Tc 2.541 0 Td (the )Tj 0.0109 Tc 1.847 0 Td (ventilatory )Tj -0.0166 Tc 5.114 0 Td (effect )Tj -0.0033 Tc 2.869 0 Td (this )Tj 0.0067 Tc 2.124 0 Td (vascular )Tj -0.0166 Tc 4.007 0 Td (effect )Tj -0.035 Tc 10.1489 0 0 10.4 287.92 280.56 Tm (is )Tj 0.0212 Tc 10.4 0 0 10.4 66.26 269.53 Tm (probably )Tj 0.0029 Tc 4.058 0 Td (variable )Tj 0.176 0.176 0.165 rg -0.0079 Tc 3.59 0 Td (from )Tj 0.247 0.247 0.235 rg 0.0272 Tc 2.31 0 Td (one )Tj 0.0179 Tc 1.858 0 Td (patient )Tj 0.01 Tc 3.18 0 Td (to )Tj 0.0192 Tc 1.146 0 Td (another. )Tj -0.0337 Tc -15.135 -1.015 Td (In )Tj -0.0088 Tc 1.435 0 Td (the )Tj 0.0053 Tc 1.805 0 Td (present )Tj 0.0018 Tc 3.505 0 Td (work, )Tj 0.0093 Tc 2.952 0 Td (there )Tj -0.0147 Tc 2.587 0 Td (were )Tj 0.0187 Tc 2.492 0 Td (no )Tj 0.0055 Tc 1.561 0 Td (changes )Tj -0.0224 Tc 3.832 0 Td (in )Tj 0.0162 Tc -21.223 -1.062 Td (haemodynamic )Tj 0.05 Tc 10.6431 0 0 10.4 134.3 247.93 Tm (data )Tj -0.0224 Tc 10.4 0 0 10.4 157.35 247.93 Tm (in )Tj 0.0191 Tc 1.164 0 Td (patients )Tj 0.0093 Tc 3.641 0 Td (treated )Tj 0.0074 Tc 3.176 0 Td (for )Tj 0.0041 Tc 1.617 0 Td (one )Tj 0.0281 Tc 1.809 0 Td (year )Tj 0 Tc -20.169 -1.062 Td (w)Tj 0.114 0.118 0.106 rg 0.685 0 Td (i)Tj 0.247 0.247 0.235 rg -0.035 Tc 10.3833 0 0 10.4 76.29 236.89 Tm (th )Tj 0 Tc 10.4 0 0 10.4 86.77 236.89 Tm (a)Tj 0.114 0.118 0.106 rg 0.51 0 Td (l)Tj 0.247 0.247 0.235 rg 0.0124 Tc 0.237 0 Td (mitrine )Tj 0.0002 Tc 3.188 0 Td (bismesylate)Tj 0.372 0.372 0.361 rg 0 Tc 4.732 0 Td (. )Tj 0.247 0.247 0.235 rg 0.0394 Tc 0.428 0 Td (The )Tj 0.012 Tc 1.854 0 Td (haemodynamic )Tj 0.0036 Tc 6.448 0 Td (stabil\255)Tj -0.0112 Tc -19.379 -1.062 Td (ity )Tj -0.0035 Tc 1.614 0 Td (confirms )Tj 0.011 Tc 4.119 0 Td (prev)Tj 0.114 0.118 0.106 rg 0 Tc 1.836 0 Td (i)Tj 0.247 0.247 0.235 rg 0.008 Tc 0.276 0 Td (ous )Tj 0.0032 Tc 2.026 0 Td (studies )Tj 0.0116 Tc 3.386 0 Td (performed )Tj -0.0104 Tc 4.927 0 Td (on )Tj 0.0095 Tc 1.669 0 Td (more )Tj -0.0067 Tc -19.905 -1.062 Td (severe )Tj 0.0191 Tc 2.832 0 Td (patients )Tj 0.0186 Tc 3.634 0 Td (after )Tj 0.0041 Tc 2.263 0 Td (one )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.2034 0 0 10.4 175.43 214.8 Tm ([10], )Tj EMC ET BT /T1_0 1 Tf 0.0229 Tc 10.4 0 0 10.4 197.64 214.8 Tm (four )Tj -0.035 Tc 9.0515 0 0 10.4 219.62 214.8 Tm ([3] )Tj 0.0456 Tc 10.4 0 0 10.4 233.65 214.8 Tm (and )Tj 0 Tc 1.937 0 Td (6 )Tj 0.0215 Tc 0.841 0 Td (months )Tj -0.035 Tc 9.439 0 0 10.4 66.01 204.25 Tm ([18] )Tj 0 Tc 10.4 0 0 10.4 86.85 204.25 Tm (t)Tj 0.114 0.118 0.106 rg 0.325 0 Td (r)Tj 0.247 0.247 0.235 rg 0.0195 Tc 0.313 0 Td (eatment; )Tj -0.0224 Tc 4.11 0 Td (in )Tj 0.0218 Tc 1.337 0 Td (addition )Tj 0.0155 Tc 3.965 0 Td (stabil)Tj 0.114 0.118 0.106 rg 0.016 Tc 2.267 0 Td (it)Tj 0.247 0.247 0.235 rg 0 Tc 0.608 0 Td (y )Tj 0.05 Tc 11.1292 0 0 10.4 231.73 204.25 Tm (of )Tj 0.176 0.176 0.165 rg 0.0129 Tc 10.4 0 0 10.4 246.23 204.25 Tm (right )Tj 0.247 0.247 0.235 rg 0.0327 Tc 2.492 0 Td (heart )Tj -0.0214 Tc -19.857 -1.062 Td (fu)Tj 0.114 0.118 0.106 rg 0 Tc 0.887 0 Td (n)Tj 0.247 0.247 0.235 rg 0.0135 Tc 0.499 0 Td (ction )Tj -0.0224 Tc 2.586 0 Td (in )Tj 0.039 Tc 1.337 0 Td (COLD )Tj 0.05 Tc 10.9841 0 0 10.4 156.02 193.21 Tm (pat)Tj 0.114 0.118 0.106 rg 0 Tc 10.4 0 0 10.4 170.31 193.21 Tm (i)Tj 0.247 0.247 0.235 rg 0.0241 Tc 0.229 0 Td (ents )Tj 0.017 Tc 2.223 0 Td (treated )Tj 0 Tc 3.417 0 Td (w)Tj 0.114 0.118 0.106 rg 0.685 0 Td (i)Tj 0.247 0.247 0.235 rg 0.01 Tc 0.283 0 Td (th )Tj -0.0076 Tc 1.377 0 Td (aJrnitrine )Tj -0.0044 Tc -18.265 -1.062 Td (bismesylate )Tj 0.0283 Tc 4.937 0 Td (has )Tj 0.0053 Tc 1.663 0 Td (been )Tj 0.0084 Tc 2.159 0 Td (observed )Tj 0.0186 Tc 3.968 0 Td (after )Tj 0.0095 Tc 2.178 0 Td (more )Tj 0.0274 Tc 2.399 0 Td (than )Tj -0.035 Tc 9.8147 0 0 10.4 267.73 182.16 Tm (five )Tj 0.0472 Tc 10.4 0 0 10.4 285.11 182.16 Tm (yr )Tj 0.0049 Tc -21.103 -1.061 Td (\(personal )Tj 0.0084 Tc 4.202 0 Td (observations\). )Tj 0.176 0.176 0.165 rg 0.05 Tc 10.5034 0 0 10.4 174.17 171.13 Tm (In )Tj 0.247 0.247 0.235 rg 0.0259 Tc 10.4 0 0 10.4 188.06 171.13 Tm (contrast )Tj 0.01 Tc 3.838 0 Td (to )Tj 0.05 Tc 10.5338 0 0 10.4 240.86 171.13 Tm (our )Tj -0.0158 Tc 10.4 0 0 10.4 260.52 171.13 Tm (findings )Tj -0.035 Tc 8.8064 0 0 10.4 65.24 160.09 Tm (MACNEE )Tj /T1_2 1 Tf -0.0007 Tc 10.2 0 0 10.2 104.55 160.09 Tm (et )Tj 0.176 0.176 0.165 rg -0.035 Tc 10.1247 0 0 10.2 115.61 160.09 Tm (a/. )Tj 0.247 0.247 0.235 rg /T1_0 1 Tf 9.7536 0 0 10.4 129.36 160.09 Tm ([12] )Tj 0.0004 Tc 10.4 0 0 10.4 148.68 160.09 Tm (found )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0238 Tc 10.4 0 0 10.4 177.0304 160.09 Tm (in )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.8147 0 0 10.4 189.01 160.09 Tm (five )Tj 0.0191 Tc 10.4 0 0 10.4 207.38 160.09 Tm (patients )Tj 0 Tc 3.588 0 Td [(a )-87(s)]TJ 0.114 0.118 0.106 rg 1.202 0 Td (l)Tj 0.247 0.247 0.235 rg 0.0105 Tc 0.231 0 Td (ight )Tj 0.0355 Tc 1.948 0 Td (but )Tj -0.0037 Tc -20.646 -1.016 Td (significant )Tj -0.019 Tc 4.49 0 Td (rise )Tj 0.0238 Tc 1.608 0 Td (in )Tj ET BT /Suspect <>BDC 0.176 0.176 0.165 rg /T1_0 1 Tf 0.0197 Tc 10.4 0 0 10.4 140.1232 149.5236 Tm (Ppa )Tj EMC ET BT 0.247 0.247 0.235 rg /T1_0 1 Tf 0.0186 Tc 10.4 0 0 10.4 158.7808 149.5236 Tm (after )Tj 0.0093 Tc 2.177 0 Td (three )Tj 0.0215 Tc 2.309 0 Td (months )Tj 0.05 Tc 11.1292 0 0 10.4 240.37 149.52 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.2459 0 0 10.4 252.12 149.52 Tm (100 )Tj EMC ET BT /T1_0 1 Tf -0.0264 Tc 10.4 0 0 10.4 269.26 149.52 Tm (mg )Tj 0.05 Tc 11.1292 0 0 10.4 285.01 149.52 Tm (of )Tj 0.0276 Tc 10.4 0 0 10.4 65.18 138.49 Tm (oral )Tj 0.0124 Tc 2.261 0 Td (almitrine )Tj -0.0008 Tc 4.339 0 Td (daily)Tj 0.372 0.372 0.361 rg 0 Tc 2.019 0 Td (. )Tj 0.176 0.176 0.165 rg 0.0175 Tc 0.843 0 Td (Therefore )Tj 0.247 0.247 0.235 rg 0.016 Tc 4.708 0 Td (it )Tj -0.035 Tc 10.1489 0 0 10.4 225.04 138.49 Tm (is )Tj -0.0003 Tc 10.4 0 0 10.4 238.07 138.49 Tm (necessary )Tj 0.05 Tc 10.4772 0 0 10.4 285.09 138.49 Tm (to )Tj 0.02 Tc 10.4 0 0 10.4 65.18 127.44 Tm (compa)Tj 0.114 0.118 0.106 rg 0 Tc 2.778 0 Td (r)Tj 0.247 0.247 0.235 rg 0.313 0 Td (e )Tj 0.0162 Tc 0.977 0 Td (their )Tj 0.0125 Tc 2.405 0 Td (patients )Tj -0.0059 Tc 3.736 0 Td (with )Tj 0.0041 Tc 2.352 0 Td (those )Tj 0.0238 Tc 2.579 0 Td (in )Tj 0.0342 Tc 1.337 0 Td (other )Tj 0.0109 Tc 2.672 0 Td (studies )Tj 0.0271 Tc -19.151 -1.062 Td (\(tab)Tj 0.114 0.118 0.106 rg 0 Tc 1.664 0 Td (l)Tj 0.247 0.247 0.235 rg 0.229 0 Td (e )Tj 0.176 0.176 0.165 rg -0.0334 Tc 1.065 0 Td (IV\). )Tj 0.247 0.247 0.235 rg 0.05 Tc 10.5034 0 0 10.4 118.97 116.4 Tm (In)Tj 0.114 0.118 0.106 rg 0 Tc 10.4 0 0 10.4 128.55 116.4 Tm (i)Tj 0.247 0.247 0.235 rg -0.0085 Tc 0.283 0 Td (tial )Tj 0.176 0.176 0.165 rg 0.0101 Tc 1.94 0 Td (hypoxia )Tj 0.247 0.247 0.235 rg 0.0225 Tc 3.867 0 Td (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 12.0563 0 0 10.8 214.43 116.4 Tm (C0)Tj 0 Tc 6.2 0 0 6.2 229.41 114.48 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0178 Tc 10.4 0 0 10.4 239.99 116.4 Tm (retention )Tj 0.05 Tc 11.1292 0 0 10.4 285.01 116.4 Tm (of )Tj 0.0068 Tc 10.4 0 0 10.4 65.23 105.84 Tm (Macnee)Tj 0.372 0.372 0.361 rg 0 Tc 3.224 0 Td (')Tj 0.247 0.247 0.235 rg 0.228 0 Td (s )Tj 0.0125 Tc 0.986 0 Td (patients )Tj -0.0147 Tc 3.782 0 Td (were )Tj 0.0051 Tc 2.485 0 Td (identical )Tj 0.01 Tc 4.113 0 Td (to )Tj 0.0174 Tc 1.378 0 Td (ours )Tj 0.0355 Tc 2.411 0 Td (but )Tj -0.035 Tc 10.1035 0 0 10.4 279.27 105.84 Tm (less )Tj -0.0251 Tc 10.4 0 0 10.4 65.13 94.8 Tm (severe )Tj 0.0121 Tc 3.288 0 Td (than )Tj 0.0041 Tc 2.677 0 Td (those )Tj 0.05 Tc 11.1292 0 0 10.4 157.81 94.8 Tm (of )Tj 0.0131 Tc 10.4 0 0 10.4 174.57 94.8 Tm (some )Tj 0.176 0.176 0.165 rg 0.0342 Tc 2.959 0 Td (other )Tj -0.0001 Tc 3.008 0 Td (middle )Tj 0.247 0.247 0.235 rg 0.0216 Tc 3.599 0 Td (term )Tj 0.0078 Tc -20.075 -1.062 Td (haemodynamic )Tj 0.0124 Tc 6.452 0 Td (almitrine )Tj 0.0223 Tc 3.965 0 Td (stud)Tj 0.114 0.118 0.106 rg 0 Tc 1.76 0 Td (i)Tj 0.247 0.247 0.235 rg -0.0276 Tc 0.229 0 Td (es )Tj -0.035 Tc 10.311 0 0 10.4 205.19 83.76 Tm ([3, )Tj 0.114 0.118 0.106 rg 0 Tc 10.4 0 0 10.4 219.48 83.76 Tm (1)Tj 0.247 0.247 0.235 rg -0.035 Tc 10.1675 0 0 10.4 223.09 83.76 Tm (0]. )Tj ET BT /Suspect <>BDC 0.176 0.176 0.165 rg /T1_0 1 Tf 0.0428 Tc 10.4 0 0 10.4 236.59 83.76 Tm (Ppa )Tj EMC ET BT 0.247 0.247 0.235 rg /T1_0 1 Tf -0.0144 Tc 10.4 0 0 10.4 255.8196 83.76 Tm (va)Tj 0.114 0.118 0.106 rg 0 Tc 0.962 0 Td (l)Tj 0.247 0.247 0.235 rg -0.0195 Tc 0.286 0 Td (ues )Tj 0.05 Tc 11.6856 0 0 10.4 284.53 83.76 Tm (of )Tj 0.176 0.176 0.165 rg 0.0159 Tc 10.4 0 0 10.4 320.59 738.97 Tm (Macnee's )Tj 0.247 0.247 0.235 rg 0.0187 Tc 4.098 0 Td (study )Tj -0.0147 Tc 2.506 0 Td (were )Tj 0.0067 Tc 2.11 0 Td (smaller )Tj 0.0428 Tc 3.242 0 Td (than )Tj 0.0238 Tc 2.117 0 Td (in )Tj -0.0084 Tc 1.106 0 Td (all )Tj 0.0457 Tc 1.247 0 Td (other )Tj 0.0066 Tc 2.487 0 Td (studies, )Tj 0.0033 Tc -18.917 -1.062 Td (including )Tj -0.0033 Tc 4.43 0 Td (ours. )Tj 0.0163 Tc 2.632 0 Td (The )Tj 0.0154 Tc 2.222 0 Td (most )Tj 0.0224 Tc 2.572 0 Td (striking )Tj 0.0084 Tc 3.789 0 Td (discrepancy )Tj 0.05 Tc 11.1292 0 0 10.4 540.85 727.92 Tm (of )Tj 0.0159 Tc 10.4 0 0 10.4 320.59 717.36 Tm (Macnee's )Tj 0.0187 Tc 4.237 0 Td (study )Tj -0.035 Tc 9.3682 0 0 10.4 392.08 717.36 Tm (is )Tj 0.0143 Tc 10.4 0 0 10.4 402.21 717.36 Tm (the )Tj 0.0046 Tc 1.656 0 Td (lack )Tj 0.05 Tc 11.6856 0 0 10.4 440.53 717.36 Tm (of )Tj 0.0055 Tc 10.4 0 0 10.4 453.45 717.36 Tm (significant )Tj 0.0032 Tc 4.667 0 Td (increase )Tj 0.05 Tc 11.6856 0 0 10.4 540.37 717.36 Tm (of )Tj ET BT /Suspect <>BDC 0.176 0.176 0.165 rg /T1_0 1 Tf 0.0428 Tc 10.4 0 0 10.4 320.59 706.33 Tm (Pao)Tj 0 Tc 6.2 0 0 6.2 337.41 704.41 Tm (2 )Tj EMC ET BT 0.247 0.247 0.235 rg /T1_0 1 Tf 0.0186 Tc 10.4 0 0 10.4 345.97 706.33 Tm (after )Tj 0.0208 Tc 2.315 0 Td (three )Tj 0.0215 Tc 2.447 0 Td (months )Tj 0.0113 Tc 3.507 0 Td (therapy. )Tj 0.176 0.176 0.165 rg 0.05 Tc 10.5589 0 0 10.4 471.27 706.33 Tm (The )Tj 0.247 0.247 0.235 rg 10.4235 0 0 10.4 492.81 706.33 Tm (st)Tj 0.114 0.118 0.106 rg 0 Tc 10.4 0 0 10.4 500.64 706.33 Tm (u)Tj 0.247 0.247 0.235 rg 0.0244 Tc 0.498 0 Td (dy )Tj 0.176 0.176 0.165 rg 0.0045 Tc 1.431 0 Td (clearly )Tj 0.247 0.247 0.235 rg 0.0009 Tc -19.245 -1.016 Td (inclu)Tj 0.114 0.118 0.106 rg 0 Tc 1.984 0 Td (d)Tj 0.247 0.247 0.235 rg -0.0002 Tc 0.507 0 Td (ed )Tj 0 Tc 1.477 0 Td (a )Tj 0.114 0.118 0.106 rg 0.971 0 Td (l)Tj 0.247 0.247 0.235 rg -0.0001 Tc 0.275 0 Td (arge )Tj 0 Tc 2.271 0 Td (n)Tj 0.114 0.118 0.106 rg 0.509 0 Td (u)Tj 0.247 0.247 0.235 rg 0.0095 Tc 0.506 0 Td (mber )Tj 0 Tc 2.577 0 Td (o)Tj 0.114 0.118 0.106 rg 0.552 0 Td (f )Tj 0.247 0.247 0.235 rg 0.0169 Tc 0.795 0 Td (non-responders. )Tj 0.176 0.176 0.165 rg 0.05 Tc 10.44 0 0 10.4 525.07 695.76 Tm (From )Tj -0.0038 Tc 10.4 0 0 10.4 320.63 684.73 Tm (results )Tj 0.247 0.247 0.235 rg -0.0224 Tc 3.131 0 Td (in )Tj 0.0143 Tc 1.298 0 Td (the )Tj 0.176 0.176 0.165 rg 0.0085 Tc 1.794 0 Td (literature, )Tj 0.247 0.247 0.235 rg 0.05 Tc 10.6148 0 0 10.4 431.9 684.73 Tm (out )Tj 11.1292 0 0 10.4 451.57 684.73 Tm (of )Tj 0.0201 Tc 10.4 0 0 10.4 465.97 684.73 Tm (approximately )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0252 Tc 10.4 0 0 10.4 534.1836 684.73 Tm (200 )Tj EMC /Suspect <>BDC 0.039 Tc -20.543 -1.062 Td (COLD )Tj EMC ET BT /T1_0 1 Tf 0.0191 Tc 10.4 0 0 10.4 352.8284 673.6852 Tm (patients )Tj 0.017 Tc 3.503 0 Td (treated )Tj -0.0127 Tc 3.094 0 Td (wit)Tj 0.114 0.118 0.106 rg 0 Tc 1.292 0 Td (h )Tj 0.247 0.247 0.235 rg 0.0124 Tc 0.775 0 Td (almitrine )Tj 0.0299 Tc 3.97 0 Td (only )Tj 0.016 Tc 2.127 0 Td (25% )Tj -0.0147 Tc 2.22 0 Td (were )Tj 0.009 Tc -20.077 -1.015 Td (non-responders )Tj -0.035 Tc 9.4074 0 0 10.4 391.45 663.12 Tm ([2]. )Tj 0.0201 Tc 10.4 0 0 10.4 409.01 663.12 Tm (Non-responders )Tj -0.004 Tc 7.195 0 Td (usually )Tj 0.114 0.118 0.106 rg 0 Tc 3.414 0 Td (h)Tj 0.247 0.247 0.235 rg 0.0048 Tc 0.498 0 Td (ave )Tj 0 Tc 1.892 0 Td (a )Tj -0.0231 Tc -21.499 -1.061 Td (mixed )Tj -0.0022 Tc 2.909 0 Td (restrictive )Tj 0.0225 Tc 4.421 0 Td (and )Tj 0.0151 Tc 1.939 0 Td (obstructive )Tj 0.0164 Tc 5.029 0 Td (functiona)Tj 0.114 0.118 0.106 rg 0 Tc 3.972 0 Td (l )Tj 0.247 0.247 0.235 rg 0.0316 Tc 0.703 0 Td (pattern )Tj 0.05 Tc 11.1292 0 0 10.4 320.05 641.05 Tm (or )Tj 0.176 0.176 0.165 rg 0.011 Tc 10.4 0 0 10.4 332.66 641.05 Tm (pure )Tj 0.247 0.247 0.235 rg 0.0032 Tc 2.111 0 Td (emphysema, )Tj 0.0225 Tc 5.354 0 Td (and )Tj -0.0147 Tc 1.81 0 Td (were )Tj 0.176 0.176 0.165 rg 0.05 Tc 10.8321 0 0 10.4 451.67 641.05 Tm (not )Tj 0.247 0.247 0.235 rg -0.0014 Tc 10.4 0 0 10.4 469.33 641.05 Tm (explicitly )Tj 0.002 Tc 4.015 0 Td (excluded )Tj 0.0075 Tc -18.37 -1.062 Td (from )Tj 0 Tc 2.501 0 Td (t)Tj 0.114 0.118 0.106 rg 0.325 0 Td (h)Tj 0.247 0.247 0.235 rg 0.498 0 Td (e )Tj 0.176 0.176 0.165 rg 0.0068 Tc 0.929 0 Td (Macnee )Tj 0.247 0.247 0.235 rg 0.0147 Tc 3.699 0 Td (population. )Tj 0.176 0.176 0.165 rg 0.0039 Tc 5.209 0 Td (His )Tj 0.247 0.247 0.235 rg 0.0302 Tc 1.883 0 Td (study )Tj 0.005 Tc 2.727 0 Td (essent)Tj 0.114 0.118 0.106 rg 0 Tc 2.494 0 Td (i)Tj 0.247 0.247 0.235 rg 0.275 0 Td (a)Tj 0.114 0.118 0.106 rg -0.035 Tc 9.5285 0 0 10.4 538.48 630 Tm (ll)Tj 0.247 0.247 0.235 rg 0 Tc 10.4 0 0 10.4 543.83 630 Tm (y )Tj -0.0071 Tc -21.521 -1.015 Td (shows )Tj 0.0402 Tc 2.873 0 Td (that )Tj 0.0067 Tc 1.977 0 Td (almitrine )Tj 0.0164 Tc 4.023 0 Td (therapy )Tj -0.0127 Tc 3.463 0 Td (wit)Tj 0.114 0.118 0.106 rg 0 Tc 1.292 0 Td (h)Tj 0.247 0.247 0.235 rg 0.05 Tc 10.6148 0 0 10.4 466.94 619.44 Tm (out )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0428 Tc 10.4 0 0 10.4 485.71 619.44 Tm (Pao)Tj 0 Tc 6.2 0 0 6.2 502.53 617.05 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0065 Tc 10.4 0 0 10.4 510.15 619.44 Tm (improve\255)Tj 0.0127 Tc -18.27 -1.061 Td (ment )Tj 0.0017 Tc 2.347 0 Td (induces )Tj 0 Tc 3.321 0 Td (a )Tj 0.0041 Tc 0.781 0 Td (slight )Tj -0.0034 Tc 2.544 0 Td (increase )Tj -0.035 Tc 9.9195 0 0 10.4 450.64 608.41 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0428 Tc 10.4 0 0 10.4 461.71 608.41 Tm (Ppa )Tj EMC ET BT 0.114 0.118 0.106 rg /T1_0 1 Tf -0.035 Tc 9.9195 0 0 10.4 481.84 608.41 Tm (in )Tj 0.247 0.247 0.235 rg 0.0191 Tc 10.4 0 0 10.4 492.98 608.41 Tm (patients )Tj -0.0059 Tc 3.597 0 Td (with )Tj -0.0265 Tc -20.223 -1.062 Td (low )Tj 0.007 Tc 1.708 0 Td (initial )Tj -0.0122 Tc 2.638 0 Td (values. )Tj 0.0376 Tc 3.089 0 Td (From )Tj 0.0373 Tc 2.54 0 Td (tab)Tj 0.114 0.118 0.106 rg 0 Tc 1.333 0 Td (l)Tj 0.247 0.247 0.235 rg 0.229 0 Td (e )Tj 0.0212 Tc 0.65 0 Td (IV )Tj 0.176 0.176 0.165 rg 0.05 Tc 10.615 0 0 10.4 460.71 597.36 Tm (it )Tj 0.247 0.247 0.235 rg 0.0324 Tc 10.4 0 0 10.4 469.34 597.36 Tm (can )Tj 0.0358 Tc 1.718 0 Td (be )Tj -0.014 Tc 1.185 0 Td (seen )Tj 0.0402 Tc 2.042 0 Td (that )Tj 0.0238 Tc 1.887 0 Td (in )Tj 0.0125 Tc -21.174 -1.015 Td (patients )Tj 0.176 0.176 0.165 rg -0.0213 Tc 3.551 0 Td (with )Tj 0.247 0.247 0.235 rg -0.0042 Tc 2.067 0 Td (elevated )Tj -0.0007 Tc 3.648 0 Td (initial )Tj ET BT /Suspect <>BDC 0.176 0.176 0.165 rg /T1_0 1 Tf 0.0221 Tc 10.4 0 0 10.4 444.432 586.804 Tm (Ppa, )Tj EMC ET BT 0.247 0.247 0.235 rg /T1_0 1 Tf 0.0187 Tc 10.4 0 0 10.4 467.0312 586.804 Tm (no )Tj 0.0282 Tc 1.328 0 Td (further )Tj 0.0032 Tc 3.234 0 Td (increase )Tj -0.0065 Tc -18.693 -1.062 Td (occu)Tj 0.114 0.118 0.106 rg 0 Tc 1.901 0 Td (r)Tj 0.247 0.247 0.235 rg 0.356 0 Td (s )Tj -0.0059 Tc 0.706 0 Td (with )Tj 0.0038 Tc 2.113 0 Td (almitrine. )Tj 0.176 0.176 0.165 rg 0.0315 Tc 4.248 0 Td (Thus )Tj 0.247 0.247 0.235 rg 0.0041 Tc 2.445 0 Td (one )Tj 0.0437 Tc 1.754 0 Td (cannot )Tj 0 Tc 3.242 0 Td (p)Tj 0.114 0.118 0.106 rg 0.551 0 Td (r)Tj 0.247 0.247 0.235 rg 0.0046 Tc 0.36 0 Td (edict )Tj 0.0229 Tc 2.261 0 Td (from )Tj -0.0088 Tc -19.93 -1.061 Td (the )Tj 0.007 Tc 1.794 0 Td (initial )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0197 Tc 10.4 0 0 10.4 369.5624 564.7248 Tm (Ppa )Tj EMC ET BT /T1_0 1 Tf -0.0088 Tc 10.4 0 0 10.4 392.1408 564.7248 Tm (the )Tj 0.0171 Tc 1.742 0 Td (subsequent )Tj -0.0074 Tc 5.127 0 Td (effect )Tj 0.05 Tc 11.1292 0 0 10.4 492.37 564.73 Tm (of )Tj 0.0089 Tc 10.4 0 0 10.4 507.25 564.73 Tm (almitrine. )Tj 0.176 0.176 0.165 rg 0.0117 Tc -18.044 -1.015 Td (Therefore )Tj 0.247 0.247 0.235 rg -0.0088 Tc 4.621 0 Td (the )Tj 0.0058 Tc 1.746 0 Td (absence )Tj 0.05 Tc 11.1292 0 0 10.4 424.21 554.17 Tm (of )Tj 0 Tc 10.4 0 0 10.4 438.61 554.17 Tm (a)Tj 0.114 0.118 0.106 rg 0.51 0 Td (l)Tj 0.247 0.247 0.235 rg 0.0124 Tc 0.237 0 Td (mitrine )Tj 0.114 0.118 0.106 rg 0 Tc 3.509 0 Td (h)Tj 0.247 0.247 0.235 rg 0.0211 Tc 0.544 0 Td (aemo)Tj 0.114 0.118 0.106 rg 0 Tc 2.263 0 Td (d)Tj 0.247 0.247 0.235 rg 0.0127 Tc 0.516 0 Td (ynamic )Tj 0.0105 Tc -19.024 -1.062 Td (change )Tj 0.0238 Tc 3.232 0 Td (in )Tj 0.0143 Tc 1.252 0 Td (the )Tj 0.0053 Tc 1.666 0 Td (present )Tj 0.0071 Tc 3.353 0 Td (study )Tj 0.176 0.176 0.165 rg -0.035 Tc 10.1489 0 0 10.4 445.84 543.12 Tm (is )Tj 0.247 0.247 0.235 rg 0.0324 Tc 10.4 0 0 10.4 456.95 543.12 Tm (not )Tj 0.0017 Tc 1.744 0 Td (explained )Tj 0.176 0.176 0.165 rg -0.0212 Tc 4.396 0 Td (by )Tj 0.247 0.247 0.235 rg 0.0373 Tc 1.381 0 Td (the )Tj 0.018 Tc -20.778 -1.061 Td (fact )Tj 0.0402 Tc 2.086 0 Td (that )Tj 0.0143 Tc 2.123 0 Td (the )Tj 0.0231 Tc 1.712 0 Td (patients' )Tj -0.0007 Tc 3.959 0 Td (initial )Tj 0.176 0.176 0.165 rg 0.0162 Tc 2.869 0 Td (haemodynamic )Tj 0.247 0.247 0.235 rg -0.0016 Tc 6.737 0 Td (values )Tj -0.0147 Tc -19.43 -1.062 Td (were )Tj 0.176 0.176 0.165 rg 0.05 Tc 10.4827 0 0 10.4 342.71 521.05 Tm (not )Tj 0.247 0.247 0.235 rg -0.0126 Tc 10.4 0 0 10.4 360.33 521.05 Tm (sufficiently )Tj -0.014 Tc 4.708 0 Td (seve)Tj 0.114 0.118 0.106 rg 0 Tc (r)Tj 0.247 0.247 0.235 rg -0.0271 Tc 2.035 0 Td (e. )Tj 0.05 Tc 11.609 0 0 10.4 328.72 510.49 Tm (In )Tj 0.0084 Tc 10.4 0 0 10.4 342.14 510.49 Tm (conclusion)Tj 0.372 0.372 0.361 rg 0 Tc 4.471 0 Td (, )Tj 0.247 0.247 0.235 rg 0.0143 Tc 0.566 0 Td (the )Tj -0.0119 Tc 1.608 0 Td (existence )Tj 0.05 Tc 11.6856 0 0 10.4 452.53 510.49 Tm (of )Tj 0 Tc 10.4 0 0 10.4 465.01 510.49 Tm (a )Tj 0.0082 Tc 0.843 0 Td (possible )Tj 0.0216 Tc 3.646 0 Td (pulmon\255)Tj 0.0137 Tc -18.474 -1.062 Td (ary )Tj 0.176 0.176 0.165 rg 0.002 Tc 1.717 0 Td (hypertensive )Tj 0.247 0.247 0.235 rg -0.0258 Tc 5.483 0 Td (effect )Tj 0.05 Tc 10.5727 0 0 10.4 421.34 499.44 Tm (of )Tj 0.0048 Tc 10.4 0 0 10.4 433.81 499.44 Tm (alrnitrine )Tj 0.05 Tc 10.6555 0 0 10.4 476.07 499.44 Tm (in )Tj -0.0023 Tc 10.4 0 0 10.4 488.49 499.44 Tm (some )Tj 0.0191 Tc 2.509 0 Td (patients )Tj 0.0324 Tc -18.796 -1.061 Td (can )Tj -0.0103 Tc 1.995 0 Td (be )Tj 0.0054 Tc 1.419 0 Td (avoided )Tj -0.0212 Tc 3.796 0 Td (by )Tj 0.0013 Tc 1.521 0 Td (restricting )Tj 0 Tc 4.56 0 Td (a)Tj 0.114 0.118 0.106 rg 0.51 0 Td (l)Tj 0.247 0.247 0.235 rg 0.029 Tc 0.237 0 Td (mit)Tj 0.114 0.118 0.106 rg 0 Tc 1.432 0 Td (r)Tj 0.247 0.247 0.235 rg -0.0019 Tc 0.315 0 Td (ine )Tj 0.0143 Tc 1.76 0 Td (the)Tj 0.114 0.118 0.106 rg 0 Tc 1.294 0 Td (r)Tj 0.247 0.247 0.235 rg -0.0006 Tc 0.36 0 Td (apy )Tj 0.05 Tc 10.4772 0 0 10.4 539.49 488.41 Tm (to )Tj 0.0125 Tc 10.4 0 0 10.4 319.7 477.37 Tm (patients )Tj -0.0049 Tc 3.597 0 Td (who )Tj -0.035 Tc 9.2486 0 0 10.4 379.84 477.37 Tm (1\) )Tj 0 Tc 10.4 0 0 10.4 391.09 477.37 Tm (a)Tj 0.114 0.118 0.106 rg 0.517 0 Td (r)Tj 0.247 0.247 0.235 rg 0.313 0 Td (e )Tj 0.0024 Tc 0.794 0 Td (hypoxic )Tj 0.0215 Tc 3.591 0 Td (due )Tj 0.05 Tc 10.4772 0 0 10.4 464.61 477.37 Tm (to )Tj 0.0264 Tc 10.4 0 0 10.4 477.62 477.37 Tm (pure )Tj 0.0104 Tc 2.25 0 Td (obstructive )Tj 0.039 Tc -17.447 -1.015 Td (COLD )Tj 0.0225 Tc 3.231 0 Td (and )Tj -0.0295 Tc 1.897 0 Td (2\) )Tj 0.114 0.118 0.106 rg 0 Tc 1.159 0 Td (r)Tj 0.247 0.247 0.235 rg 0.0191 Tc 0.36 0 Td (espond )Tj 0.01 Tc 3.331 0 Td (to )Tj 0.0092 Tc 1.192 0 Td (almit)Tj 0.114 0.118 0.106 rg -0.001 Tc 2.133 0 Td (rin)Tj 0.247 0.247 0.235 rg 0 Tc 1.144 0 Td (e )Tj 0.176 0.176 0.165 rg 0.05 Tc 10.6555 0 0 10.4 477.99 466.81 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.9409 0 0 10.4 490.02 466.81 Tm (Jess )Tj EMC ET BT 0.247 0.247 0.235 rg /T1_0 1 Tf 0.0274 Tc 10.4 0 0 10.4 509.25 466.81 Tm (than )Tj 0 Tc 2.213 0 Td (2)Tj 0.537 0.541 0.525 rg 0.456 0 Td (-)Tj 0.247 0.247 0.235 rg 0.6 0 Td (3 )Tj 0.0308 Tc -21.544 -1.062 Td (months )Tj 0.05 Tc 11.1292 0 0 10.4 359.41 455.76 Tm (of )Tj 0.0164 Tc 10.4 0 0 10.4 376.29 455.76 Tm (therapy)Tj 0.372 0.372 0.361 rg 0 Tc 3.166 0 Td (. )Tj 0.176 0.176 0.165 rg -0.0085 Tc 0.987 0 Td (When )Tj 0.247 0.247 0.235 rg -0.0047 Tc 3.186 0 Td (these )Tj 0.0166 Tc 2.809 0 Td (conditions )Tj 0.176 0.176 0.165 rg 0.0422 Tc 5.076 0 Td (are )Tj 0.247 0.247 0.235 rg -0.004 Tc -20.667 -1.062 Td (respected )Tj 0.0187 Tc 4.615 0 Td (no )Tj 0.0056 Tc 1.838 0 Td (long-term )Tj 0.176 0.176 0.165 rg 0.012 Tc 4.854 0 Td (haemodynamic )Tj 0.247 0.247 0.235 rg -0.0074 Tc 7.052 0 Td (effect )Tj -0.035 Tc 10.1489 0 0 10.4 541.84 444.72 Tm (is )Tj 0.0249 Tc 10.4 0 0 10.4 319.09 433.69 Tm (apparent. )Tj 0 Tc 1.024 -1.062 Td (A )Tj 0.0084 Tc 1.146 0 Td (discrepancy )Tj 0.0008 Tc 5.364 0 Td (between )Tj 0.0143 Tc 3.781 0 Td (the )Tj 0.0118 Tc 1.748 0 Td (immediate )Tj 0.0225 Tc 4.798 0 Td (and )Tj -0.0045 Tc 2.033 0 Td (long\255)Tj -0.0092 Tc -19.84 -1.015 Td (term )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0018 Tc 10.4 0 0 10.4 341.7412 412.0892 Tm (vascula)Tj 0.114 0.118 0.106 rg 0 Tc 3.047 0 Td (r )Tj EMC ET BT 0.247 0.247 0.235 rg /T1_0 1 Tf -0.0338 Tc 10.4 0 0 10.4 379.0876 412.0892 Tm (effe)Tj 0 g 0 Tc 1.374 0 Td (.)Tj 0.247 0.247 0.235 rg 0.0094 Tc 0.058 0 Td (cts )Tj 0.05 Tc 11.6856 0 0 10.4 407.89 412.09 Tm (of )Tj 0.0067 Tc 10.4 0 0 10.4 419.41 412.09 Tm (almitrine )Tj 0.176 0.176 0.165 rg 0.0002 Tc 3.935 0 Td (bismesylate )Tj 0.247 0.247 0.235 rg -0.0039 Tc 4.923 0 Td (seems )Tj 0.01 Tc 2.688 0 Td (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0166 Tc 10.4 0 0 10.4 319.0916 401.0452 Tm (exist )Tj EMC ET BT /T1_0 1 Tf 0.0456 Tc 10.4 0 0 10.4 343.5732 401.0452 Tm (and )Tj 0.0165 Tc 2.073 0 Td (should )Tj 0.176 0.176 0.165 rg -0.035 Tc 10.1515 0 0 10.4 399.85 401.05 Tm (be )Tj 0.247 0.247 0.235 rg -0.0113 Tc 10.4 0 0 10.4 414.62 401.05 Tm (discussed. )Tj 0.176 0.176 0.165 rg 0.0394 Tc 4.57 0 Td (The )Tj 0.247 0.247 0.235 rg 0.0067 Tc 2.176 0 Td (vascular )Tj -0.0166 Tc 3.868 0 Td (effect )Tj 0.0068 Tc -19.791 -1.062 Td (might )Tj 0.0188 Tc 2.762 0 Td (disappear )Tj 0.0186 Tc 4.384 0 Td (after )Tj 0.0143 Tc 2.269 0 Td (the )Tj 0.176 0.176 0.165 rg 0.0204 Tc 1.615 0 Td (transient )Tj 0.247 0.247 0.235 rg -0.0258 Tc 4.008 0 Td (effect )Tj 0 Tc 2.539 0 Td (o)Tj 0.114 0.118 0.106 rg 0.552 0 Td (f )Tj 0.247 0.247 0.235 rg 0.693 0 Td (a )Tj -0.0014 Tc 0.827 0 Td (single )Tj 0.176 0.176 0.165 rg -0.0106 Tc -19.657 -1.061 Td (dose. )Tj 0.05 Tc 11.6356 0 0 10.4 344.56 378.97 Tm (If )Tj 0.247 0.247 0.235 rg 0.0121 Tc 10.4 0 0 10.4 355.65 378.97 Tm (this )Tj -0.0147 Tc 1.848 0 Td (were )Tj 0.0114 Tc 2.26 0 Td (true, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0197 Tc 10.4 0 0 10.4 421.8772 378.97 Tm (Ppa )Tj EMC ET BT /T1_0 1 Tf 0.0165 Tc 10.4 0 0 10.4 441.4604 378.97 Tm (should )Tj 0.176 0.176 0.165 rg 0.0121 Tc 3.198 0 Td (return )Tj 0.247 0.247 0.235 rg 0.01 Tc 2.906 0 Td (to )Tj 0.0162 Tc 1.202 0 Td (normal )Tj -0.035 Tc 10.1053 0 0 10.4 319.18 367.93 Tm (va)Tj 0.114 0.118 0.106 rg 0 Tc 10.4 0 0 10.4 329.19 367.93 Tm (l)Tj 0.247 0.247 0.235 rg -0.035 Tc 10.2743 0 0 10.4 332.16 367.93 Tm (ues )Tj 0.0456 Tc 10.4 0 0 10.4 347.89 367.93 Tm (and )Tj 0.0274 Tc 1.808 0 Td (then )Tj 0.0206 Tc 2.068 0 Td (further )Tj -0.0193 Tc 3.094 0 Td (dec)Tj 0.114 0.118 0.106 rg 0 Tc 1.393 0 Td (r)Tj 0.247 0.247 0.235 rg -0.0122 Tc 0.36 0 Td (ease )Tj 0.0095 Tc 1.948 0 Td (with )Tj 0.176 0.176 0.165 rg 0.0181 Tc 2.023 0 Td (improvement )Tj 0.114 0.118 0.106 rg 0 Tc 5.723 0 Td (i)Tj 0.247 0.247 0.235 rg 0.285 0 Td (n )Tj 0.0106 Tc -21.515 -1.062 Td (gas )Tj 0.0092 Tc 1.844 0 Td (exc)Tj 0.114 0.118 0.106 rg 0 Tc 1.394 0 Td (h)Tj 0.247 0.247 0.235 rg -0.0005 Tc 0.498 0 Td (ange. )Tj 0.176 0.176 0.165 rg -0.035 Tc 10.3546 0 0 10.4 385.88 356.89 Tm (We )Tj 0.247 0.247 0.235 rg -0.0109 Tc 10.4 0 0 10.4 405.5 356.89 Tm (did )Tj 0.176 0.176 0.165 rg 0.0324 Tc 1.855 0 Td (not )Tj 0.247 0.247 0.235 rg 0.0085 Tc 1.884 0 Td (observe )Tj 0.0285 Tc 3.641 0 Td (such )Tj 0 Tc 2.404 0 Td (a )Tj 0.0206 Tc 1.014 0 Td (further )Tj 0.0048 Tc -19.152 -1.015 Td (decrease )Tj 0.0109 Tc 3.737 0 Td (either )Tj -0.0224 Tc 2.633 0 Td (in )Tj 0.05 Tc 10.5338 0 0 10.4 395.42 346.33 Tm (our )Tj 0.0071 Tc 10.4 0 0 10.4 413.13 346.33 Tm (study )Tj 0.0238 Tc 2.498 0 Td (in )Tj -0.0094 Tc 1.069 0 Td (which )Tj ET BT /Suspect <>BDC 0.176 0.176 0.165 rg /T1_0 1 Tf 0.0428 Tc 10.4 0 0 10.4 478.5044 346.33 Tm (Ppa )Tj EMC ET BT 0.247 0.247 0.235 rg /T1_0 1 Tf 0.0098 Tc 10.4 0 0 10.4 497.7444 346.33 Tm (was )Tj -0.0092 Tc 1.833 0 Td (slightly )Tj 0.176 0.176 0.165 rg -0.002 Tc -19.01 -1.062 Td (increased )Tj 0.247 0.247 0.235 rg 0.05 Tc 10.7518 0 0 10.4 361.81 335.28 Tm (at )Tj ET BT /Suspect <>BDC 0.176 0.176 0.165 rg /T1_0 1 Tf -0.035 Tc 9.371 0 0 10.4 372.88 335.28 Tm (TO)Tj 0.372 0.372 0.361 rg 0 Tc 10.4 0 0 10.4 385.28 335.28 Tm (, )Tj EMC ET BT 0.247 0.247 0.235 rg /T1_0 1 Tf 0.05 Tc 10.5727 0 0 10.4 391.1 335.28 Tm (or )Tj -0.0224 Tc 10.4 0 0 10.4 403.59 335.28 Tm (in )Tj 0.0342 Tc 1.061 0 Td (other )Tj 0.0032 Tc 2.487 0 Td (studies )Tj -0.035 Tc 9.82 0 0 10.4 473.04 335.28 Tm ([3, )Tj 0.176 0.176 0.165 rg 9.2649 0 0 10.4 487.36 335.28 Tm (10] )Tj 0.247 0.247 0.235 rg 0 Tc 10.4 0 0 10.4 502.55 335.28 Tm (w)Tj 0.114 0.118 0.106 rg 0.692 0 Td (h)Tj 0.247 0.247 0.235 rg 0.0235 Tc 0.498 0 Td (ere )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.6084 0 0 10.4 530.83 335.28 Tm (Ppa )Tj EMC ET BT /T1_0 1 Tf -0.0132 Tc 10.4 0 0 10.4 318.71 324.25 Tm (was )Tj -0.0221 Tc 2.067 0 Td (even )Tj 0.114 0.118 0.106 rg -0.0346 Tc 2.41 0 Td (hi)Tj 0.247 0.247 0.235 rg 0.0129 Tc 0.777 0 Td (gher )Tj 0.05 Tc 11.3843 0 0 10.4 397.32 324.25 Tm (at )Tj ET BT /Suspect <>BDC 0.114 0.118 0.106 rg /T1_0 1 Tf -0.035 Tc 8.9962 0 0 10.4 411.28 324.25 Tm (TO)Tj 0.247 0.247 0.235 rg 0 Tc 10.4 0 0 10.4 423.62 324.25 Tm (. )Tj EMC ET BT 0.114 0.118 0.106 rg /T1_0 1 Tf 0.05 Tc 10.4937 0 0 10.4 430.95 324.25 Tm (Th)Tj 0.247 0.247 0.235 rg 0.0012 Tc 10.4 0 0 10.4 443.41 324.25 Tm (erefore )Tj 0.05 Tc 10.4033 0 0 10.4 478.46 324.25 Tm (one )Tj 0.0093 Tc 10.4 0 0 10.4 499.58 324.25 Tm (can )Tj 0.176 0.176 0.165 rg 0.0163 Tc 1.947 0 Td (hardly )Tj 0.247 0.247 0.235 rg 0.0162 Tc -19.338 -1.015 Td (retain )Tj 0.0121 Tc 2.721 0 Td (this )Tj 0.0094 Tc (hypothesis. )Tj 0.0394 Tc -1.806 -1.109 Td (The )Tj 0.0158 Tc 1.891 0 Td (observation )Tj -0.0212 Tc 5.18 0 Td (by )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0463 Tc 8 0 0 8 414.69 302.16 Tm (MACNEE )Tj EMC ET BT /T1_2 1 Tf 0.0464 Tc 10.2 0 0 10.2 452.55 302.16 Tm (et )Tj -0.035 Tc 10.1247 0 0 10.2 463.13 302.16 Tm (al. )Tj /T1_0 1 Tf 10.2034 0 0 10.4 476.39 302.16 Tm ([12], )Tj 0.05 Tc 11.1292 0 0 10.4 497.17 302.16 Tm (of )Tj 0 Tc 10.4 0 0 10.4 508.69 302.16 Tm (a )Tj 0.0145 Tc 0.747 0 Td (modest )Tj -0.0036 Tc -19.014 -1.014 Td (rise )Tj 0.176 0.176 0.165 rg -0.035 Tc 9.9195 0 0 10.4 340.72 291.61 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0428 Tc 10.4 0 0 10.4 355.15 291.61 Tm (Ppa )Tj EMC ET BT 0.247 0.247 0.235 rg /T1_0 1 Tf -0.0213 Tc 10.4 0 0 10.4 379.1948 291.61 Tm (with )Tj 0.0067 Tc 2.437 0 Td (almitrine )Tj 0.0029 Tc 4.348 0 Td (when )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.6084 0 0 10.4 478.99 291.61 Tm (Pao)Tj 0 Tc 6.2 0 0 6.2 496.29 289.21 Tm (2 )Tj EMC ET BT 0.176 0.176 0.165 rg /T1_0 1 Tf 0.0077 Tc 10.4 0 0 10.4 506.78 291.61 Tm (does )Tj 0.247 0.247 0.235 rg 0.0324 Tc 2.547 0 Td (not )Tj 0.0052 Tc -20.638 -1.062 Td (improve, )Tj 0.0011 Tc 4.287 0 Td (suggests )Tj 0.0402 Tc 4.073 0 Td (that )Tj 0 Tc 2.254 0 Td (a )Tj 0.176 0.176 0.165 rg 0.0076 Tc 1.116 0 Td (minimal )Tj ET BT /Suspect <>BDC 0.247 0.247 0.235 rg /T1_0 1 Tf 0.0067 Tc 10.4 0 0 10.4 482.8704 280.5652 Tm (vascular )Tj EMC ET BT /T1_0 1 Tf -0.0166 Tc 10.4 0 0 10.4 524.5432 280.5652 Tm (effect )Tj 0.176 0.176 0.165 rg 0.0017 Tc -19.788 -1.061 Td (persists )Tj 0.247 0.247 0.235 rg 0.0238 Tc 3.589 0 Td (in )Tj 0.0373 Tc 1.39 0 Td (the )Tj 0.0113 Tc 1.887 0 Td (long-term)Tj 0.114 0.118 0.106 rg 0 Tc 4.049 0 Td (. )Tj 0.247 0.247 0.235 rg 0.0222 Tc 0.758 0 Td (Accord)Tj 0.114 0.118 0.106 rg -0.0224 Tc 3.086 0 Td (in)Tj 0.247 0.247 0.235 rg 0 Tc 0.785 0 Td (g)Tj 0.114 0.118 0.106 rg 0.508 0 Td (l)Tj 0.247 0.247 0.235 rg -0.035 Tc 10.1169 0 0 10.4 488.15 269.53 Tm (y, )Tj 0.0272 Tc 10.4 0 0 10.4 501.98 269.53 Tm (one )Tj 0.0154 Tc 2.077 0 Td (could )Tj -0.0021 Tc -19.709 -1.062 Td (explain )Tj 0.0373 Tc 3.285 0 Td (the )Tj 0.012 Tc 1.608 0 Td (abse)Tj 0.114 0.118 0.106 rg 0 Tc 1.856 0 Td (n)Tj 0.247 0.247 0.235 rg -0.035 Tc 10.3978 0 0 10.4 393.98 258.49 Tm (ce )Tj 0.05 Tc 10.5727 0 0 10.4 406.46 258.49 Tm (of )Tj -0.019 Tc 10.4 0 0 10.4 418.55 258.49 Tm (rise )Tj 0.0238 Tc 1.7 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.6084 0 0 10.4 447.79 258.49 Tm (Ppa )Tj EMC ET BT /T1_0 1 Tf -0.0224 Tc 10.4 0 0 10.4 467.91 258.49 Tm (in )Tj 0.036 Tc 1.153 0 Td (our )Tj 0.0187 Tc 1.749 0 Td (study )Tj 0.0061 Tc 2.59 0 Td (if )Tj 0.0143 Tc 0.883 0 Td (the )Tj -0.0224 Tc -20.729 -1.062 Td (in)Tj 0.114 0.118 0.106 rg 0 Tc 0.738 0 Td (i)Tj 0.247 0.247 0.235 rg 0.0104 Tc 0.329 0 Td (tia)Tj 0.114 0.118 0.106 rg 0 Tc 1.056 0 Td (l )Tj 0.247 0.247 0.235 rg 0.0158 Tc 0.653 0 Td (vasoconst)Tj 0.114 0.118 0.106 rg 0.0365 Tc 4.062 0 Td (ri)Tj 0.247 0.247 0.235 rg 0.0135 Tc 0.637 0 Td (ction )Tj -0.0132 Tc 2.501 0 Td (was )Tj 0.0038 Tc 1.938 0 Td (reduced )Tj 0.05 Tc 11.1292 0 0 10.4 480.37 247.44 Tm (or )Tj 0.0153 Tc 10.4 0 0 10.4 494.41 247.44 Tm (balanced )Tj -0.0212 Tc 4.108 0 Td (by )Tj 0.0342 Tc -21.011 -1.014 Td (other )Tj 0.0084 Tc 2.86 0 Td (factors, )Tj -0.0018 Tc 3.786 0 Td (especia)Tj 0.114 0.118 0.106 rg -0.035 Tc 9.5285 0 0 10.4 418.48 236.89 Tm (ll)Tj 0.247 0.247 0.235 rg 0 Tc 10.4 0 0 10.4 423.83 236.89 Tm (y )Tj -0.0089 Tc 1.19 0 Td (an )Tj 0.0135 Tc 1.663 0 Td (improvement )Tj -0.0224 Tc 6.185 0 Td (in )Tj 0.0106 Tc 1.477 0 Td (gas )Tj -0.0041 Tc -20.679 -1.062 Td (exchange. )Tj 0.176 0.176 0.165 rg -0.035 Tc 9.2048 0 0 10.4 366.68 225.85 Tm (RoMALDINI )Tj 0.247 0.247 0.235 rg /T1_2 1 Tf 0.05 Tc 10.1514 0 0 9.7 420.39 225.85 Tm (et )Tj -0.035 Tc 10.1247 0 0 10.2 433.85 225.85 Tm (al. )Tj /T1_0 1 Tf 9.7536 0 0 10.4 450 225.85 Tm ([23] )Tj 0.019 Tc 10.4 0 0 10.4 471.35 225.85 Tm (reported )Tj 0.176 0.176 0.165 rg 0.05 Tc 10.5068 0 0 10.4 513.57 225.85 Tm (that )Tj 0.247 0.247 0.235 rg 0.0373 Tc 10.4 0 0 10.4 536.53 225.85 Tm (an )Tj -0.0034 Tc -20.952 -1.062 Td (increase )Tj 0.0238 Tc 3.6 0 Td (in )Tj -0.0088 Tc 1.16 0 Td (the )Tj 0.0111 Tc 1.563 0 Td (inspire)Tj 0.114 0.118 0.106 rg 0 Tc 2.768 0 Td (d )Tj 0.247 0.247 0.235 rg -0.0172 Tc 0.877 0 Td (oxyge)Tj 0.114 0.118 0.106 rg 0 Tc 2.409 0 Td (n )Tj 0.247 0.247 0.235 rg 0.0085 Tc 0.866 0 Td (fraction )Tj 0.0033 Tc 3.564 0 Td (resulted )Tj 0.0238 Tc 3.546 0 Td (in )Tj 0.176 0.176 0.165 rg 0 Tc 1.152 0 Td (a )Tj 0.247 0.247 0.235 rg -0.0018 Tc -21.553 -1.062 Td (decrease )Tj 0.05 Tc 11.1292 0 0 10.4 357.49 203.76 Tm (of )Tj 0.0373 Tc 10.4 0 0 10.4 369.09 203.76 Tm (the )Tj 0.0126 Tc 1.62 0 Td (pressor )Tj 0.176 0.176 0.165 rg 0.0148 Tc 3.182 0 Td (response )Tj 0.247 0.247 0.235 rg 0.01 Tc 3.921 0 Td (to )Tj 0.0048 Tc 1.146 0 Td (alrnitrine )Tj -0.0224 Tc 3.971 0 Td (in )Tj -0.0017 Tc 1.107 0 Td (dogs. )Tj 0.0394 Tc -19.891 -1.061 Td (The )Tj 0.0041 Tc 1.979 0 Td (slight )Tj 0.0119 Tc 2.551 0 Td (ventilation )Tj -0.0034 Tc 4.793 0 Td (increase )Tj 0 Tc 3.599 0 Td (o)Tj 0.114 0.118 0.106 rg 0.564 0 Td (b)Tj 0.247 0.247 0.235 rg -0.0089 Tc 0.492 0 Td (served )Tj 0.176 0.176 0.165 rg -0.0224 Tc 2.96 0 Td (in )Tj 0.247 0.247 0.235 rg 0.05 Tc 10.5338 0 0 10.4 505.34 192.73 Tm (our )Tj 0.0187 Tc 10.4 0 0 10.4 523.53 192.73 Tm (study )Tj 0.0269 Tc -19.795 -1.016 Td (could )Tj 0.0034 Tc 2.87 0 Td (have )Tj 0.0156 Tc 2.438 0 Td (improved )Tj ET BT /Suspect <>BDC 0.176 0.176 0.165 rg /T1_0 1 Tf -0.035 Tc 10.2089 0 0 10.4 419.47 182.16 Tm (PAo)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 437.23 179.76 Tm (2 )Tj EMC ET BT 0.247 0.247 0.235 rg /T1_0 1 Tf 0.0456 Tc 10.4 0 0 10.4 446.29 182.16 Tm (and )Tj -0.0014 Tc 2.125 0 Td (induced )Tj 0 Tc 3.737 0 Td (a )Tj -0.0265 Tc 1.012 0 Td (simi)Tj 0.114 0.118 0.106 rg 0 Tc 1.713 0 Td (l)Tj 0.247 0.247 0.235 rg 0.05 Tc 11.191 0 0 10.4 537.97 182.16 Tm (ar )Tj 0 Tc 10.4 0 0 10.4 318.26 171.13 Tm (p)Tj 0.114 0.118 0.106 rg 0.551 0 Td (h)Tj 0.247 0.247 0.235 rg 0.0213 Tc 0.498 0 Td (enomenon )Tj -0.0224 Tc 4.663 0 Td (in )Tj 0.05 Tc 10.8736 0 0 10.4 389.18 171.13 Tm (our )Tj 0.176 0.176 0.165 rg 0.0028 Tc 10.4 0 0 10.4 408.02 171.13 Tm (patients. )Tj 0.247 0.247 0.235 rg 0.0163 Tc 3.774 0 Td (The )Tj 0.0227 Tc 1.903 0 Td (probable )Tj 0.0062 Tc 4.012 0 Td (vasocon\255)Tj 0.05 Tc 10.4235 0 0 10.4 317.61 160.09 Tm (st)Tj 0.114 0.118 0.106 rg 0 Tc 10.4 0 0 10.4 325.43 160.09 Tm (r)Tj 0.247 0.247 0.235 rg -0.0156 Tc 0.362 0 Td (ictive )Tj -0.0166 Tc 2.767 0 Td (effect )Tj 0.05 Tc 11.1292 0 0 10.4 387.25 160.09 Tm (of )Tj -0.0088 Tc 10.4 0 0 10.4 402.69 160.09 Tm (the )Tj 0.0382 Tc 1.793 0 Td (drug )Tj 0.027 Tc 2.492 0 Td (cou)Tj 0.114 0.118 0.106 rg -0.0233 Tc 1.524 0 Td (ld )Tj 0.247 0.247 0.235 rg 0.0058 Tc 1.383 0 Td (also )Tj 0.0034 Tc 2.271 0 Td (have )Tj 0.0053 Tc 2.494 0 Td (been )Tj 0.009 Tc -20.079 -1.062 Td (neutralized )Tj 0.025 Tc 4.894 0 Td (by )Tj 0.176 0.176 0.165 rg 0.0143 Tc 1.335 0 Td (the )Tj 0.247 0.247 0.235 rg 0.018 Tc 1.562 0 Td (direct )Tj -0.0166 Tc 2.63 0 Td (effect )Tj 0 Tc 2.493 0 Td (o)Tj 0.114 0.118 0.106 rg 0.552 0 Td (f )Tj 0.247 0.247 0.235 rg 0.0373 Tc 0.601 0 Td (an )Tj 0.0065 Tc 1.387 0 Td (improving )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 12.3229 0 0 10.8 526.02 149.05 Tm (P0)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 539.95 146.65 Tm (2)Tj 0.681 0.387 Td (, )Tj EMC ET BT /T1_0 1 Tf -0.0094 Tc 10.4 0 0 10.4 318.23 138.01 Tm (which )Tj 0 Tc 3.138 0 Td (m)Tj 0.114 0.118 0.106 rg (i)Tj 0.247 0.247 0.235 rg 0.015 Tc 1.101 0 Td (ght )Tj 0.003 Tc 2.085 0 Td (reduce )Tj 0.0024 Tc 3.415 0 Td (hypoxic )Tj 0.01 Tc 3.968 0 Td (vasoconstriction )Tj -0.0224 Tc 7.47 0 Td (in )Tj 0.0049 Tc -21.185 -1.016 Td (general )Tj 0.0456 Tc 3.275 0 Td (and )Tj 0.0297 Tc 1.859 0 Td (perhaps )Tj 0.0058 Tc 3.634 0 Td (also )Tj 0.0056 Tc 1.951 0 Td (polycythaernia )Tj -0.035 Tc 9.0957 0 0 10.4 495.25 127.44 Tm (\(ARNAUD )Tj /T1_2 1 Tf 0.0357 Tc 9.7 0 0 9.7 538.95 127.44 Tm (et )Tj -0.015 Tc 10.2 0 0 10.2 317.69 116.4 Tm (a/. )Tj /T1_0 1 Tf -0.035 Tc 8.1826 0 0 10.3 331.48 116.4 Tm ([1 )Tj -0.0209 Tc 10.3 0 0 10.3 338.77 116.4 Tm (]\). )Tj 0 Tc 10.4 0 0 10.4 328.3 105.36 Tm (A )Tj -0.0001 Tc 1.477 0 Td (minimal )Tj 0.0127 Tc 4.2 0 Td (vasoconstrictor )Tj -0.0258 Tc 7.053 0 Td (effect )Tj 0.05 Tc 11.1292 0 0 10.4 491.41 105.36 Tm (of )Tj 0.0124 Tc 10.4 0 0 10.4 508.21 105.36 Tm (almitrine )Tj -0.0135 Tc -18.265 -1.062 Td (bismesy)Tj 0.114 0.118 0.106 rg 0 Tc 3.175 0 Td (l)Tj 0.247 0.247 0.235 rg 0.024 Tc 0.275 0 Td (ate )Tj -0.0039 Tc 1.762 0 Td (may )Tj 0.176 0.176 0.165 rg 0.05 Tc 11.1671 0 0 10.4 396.39 94.32 Tm (l\) )Tj 0.247 0.247 0.235 rg 0.0053 Tc 10.4 0 0 10.4 408.98 94.32 Tm (persist )Tj -0.0224 Tc 3.128 0 Td (in )Tj -0.0088 Tc 1.252 0 Td (the )Tj 0.176 0.176 0.165 rg -0.0026 Tc 1.748 0 Td (long )Tj 0.247 0.247 0.235 rg -0.0002 Tc 2.267 0 Td (term, )Tj -0.035 Tc 9.8576 0 0 10.4 523.62 94.32 Tm (2\) )Tj /T1_1 1 Tf 8.726 0 0 9.9 536.95 94.32 Tm (be )Tj /T1_0 1 Tf 0.0021 Tc 10.4 0 0 10.4 318.25 83.76 Tm (balanced )Tj 0.176 0.176 0.165 rg 0.0238 Tc 4.052 0 Td (in )Tj 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0.595 0.609 Td (, )Tj EMC ET BT 0.129 0.129 0.118 rg /T1_0 1 Tf 9.5 0 0 9.5 192.92 415.44 Tm (P)Tj 0.267 0.267 0.255 rg 0.05 Tc 10.414 0 0 9.5 199.09 415.44 Tm (aco)Tj /T1_1 1 Tf 0 Tc 5.5001 0 0 5.5001 214.52 412.09 Tm (2 )Tj 0.2 0.204 0.192 rg /T1_0 1 Tf 0.0419 Tc 9.5 0 0 9.5 219.74 415.44 Tm (and )Tj 0.129 0.129 0.118 rg 0.05 Tc 10.0022 0 0 9.5 237.08 415.44 Tm (Ppa )Tj 0.2 0.204 0.192 rg -0.035 Tc 8.5969 0 0 9.5 255.29 415.44 Tm (in )Tj 0.0177 Tc 9.5 0 0 9.5 264.39 415.44 Tm (chronic )Tj 0.0262 Tc 3.331 0 Td (studies. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0188 Tc 9.5 0 0 9.5 35.839 393.3715 Tm (Study )Tj EMC ET BT /T1_0 1 Tf 0.0201 Tc 9.5 0 0 9.5 137.3275 393.3715 Tm (Nwnberof )Tj -0.028 Tc 5.751 0 Td (Length )Tj 0.0463 Tc 2.876 0 Td (of )Tj -0.0223 Tc 3.744 0 Td (Dose )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0092 Tc 9.5 0 0 9.5 344.608 393.837 Tm (Pao)Tj 0 Tc 6.8001 0 0 6.8001 358.52 390 Tm (2)Tj -0.035 Tc 9.1804 0 0 9.5 362.86 393.84 Tm (mmHg )Tj EMC /Suspect <>BDC 0.0146 Tc 9.5 0 0 9.5 488.6 393.37 Tm (Paco)Tj 0 Tc 6.8001 0 0 6.8001 506.84 390 Tm (2)Tj -0.035 Tc 9.2873 0 0 9.5 512.14 393.37 Tm (mrnHg )Tj EMC ET BT /T1_0 1 Tf -0.011 Tc 9.5 0 0 9.5 669.08 393.37 Tm (PpammHg )Tj 0.267 0.267 0.255 rg -0.023 Tc -55.993 -1.263 Td (subjects )Tj 0.2 0.204 0.192 rg -0.0299 Tc 5.76 0 Td (study )Tj 0.0023 Tc 5.671 -1.162 Td (mg/kg/24h )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0193 Tc 8.7 0 0 8.7 310.97 370.33 Tm (initial )Tj EMC ET BT /T1_1 1 Tf 0.0035 Tc 8.8 0 0 8.8 360.94 370.33 Tm (final )Tj 0 Tc 8.6 0 0 8.6 411.67 370.33 Tm (p )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0193 Tc 8.7 0 0 8.7 450.17 370.33 Tm (initial )Tj EMC ET BT /T1_0 1 Tf 0.0058 Tc 9 0 0 9 512.54 370.33 Tm (fmal )Tj /T1_1 1 Tf 0 Tc 8.6 0 0 8.6 563.83 369.84 Tm (p )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0193 Tc 8.7 0 0 8.7 608.57 370.33 Tm (initial )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.0816 0 0 9.6 677.66 370.33 Tm (fmal )Tj /T1_1 1 Tf 0 Tc 8.6 0 0 8.6 735.19 370.33 Tm (p )Tj -0.035 Tc 8.2169 0 0 9.4 36.3 348.25 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EMC ET BT /T1_1 1 Tf 10 0 0 10 764 310.33 Tm (> )Tj /T1_0 1 Tf -0.035 Tc 9.4758 0 0 9.5 36.63 303.61 Tm (1983 )Tj 9.338 0 0 9.5 86.29 303.61 Tm (\(18\) )Tj ET BT /Suspect <>BDC 0.267 0.267 0.255 rg /T1_0 1 Tf -0.0191 Tc 9.5 0 0 9.5 149.43 303.12 Tm (10 )Tj EMC ET BT 0.2 0.204 0.192 rg /T1_0 1 Tf 0.0113 Tc 9.5 0 0 9.5 192.3605 303.614 Tm (6months )Tj 0.129 0.129 0.118 rg -0.035 Tc 8.6596 0 0 9.5 258.42 303.61 Tm (1.5 )Tj ET BT /Suspect <>BDC 0.2 0.204 0.192 rg /T1_0 1 Tf 0.0404 Tc 9.5 0 0 9.5 301.31 303.61 Tm (56.0\261 )Tj EMC ET BT /T1_0 1 Tf -0.0335 Tc 9.5 0 0 9.5 326.5515 303.61 Tm (1.5 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0415 Tc 9.5 0 0 9.5 361.3215 303.61 Tm (60\2611.1 )Tj EMC /Suspect <>BDC -0.035 Tc 9.4617 0 0 9.5 407.9 303.61 Tm (0.05 )Tj EMC ET BT /T1_0 1 Tf -0.0321 Tc 9.5 0 0 9.5 443.89 303.61 Tm (39.5 )Tj ET BT /Suspect <>BDC 0.267 0.267 0.255 rg /T1_0 1 Tf 0.05 Tc 10.9916 0 0 9.5 461.75 303.61 Tm (\2610)Tj 0.129 0.129 0.118 rg -0.035 Tc 8.5664 0 0 9.5 474.06 303.61 Tm (.7 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2.698 0 Td (1.2 )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 7.7494 0 0 9.1 558.61 270.49 Tm (O.Gl )Tj EMC ET BT /T1_0 1 Tf 0.0444 Tc 9.5 0 0 9.5 605.22 270.49 Tm (24.4\2614.7 )Tj 0.0372 Tc 7.175 0 Td (23.8\2613.6 )Tj -0.035 Tc 6.9507 0 0 8.9 731.55 270.97 Tm (NS )Tj 0.129 0.129 0.118 rg /T1_1 1 Tf 0 Tc 10 0 0 10 764 272.89 Tm (> )Tj ET BT /Suspect <>BDC 0.2 0.204 0.192 rg /T1_0 1 Tf 0.0118 Tc 6.5001 0 0 6.5001 764.15 267.12 Tm (t"' )Tj EMC /Suspect <>BDC -0.035 Tc 7.8544 0 0 9.5 36.45 247.93 Tm (MACNEE )Tj EMC ET BT /T1_2 1 Tf 0.05 Tc 8.8825 0 0 8.6 70.48 247.93 Tm (et )Tj /T1_3 1 Tf 9.5315 0 0 9 80.04 247.93 Tm (al)Tj 0.353 0.357 0.345 rg 0 Tc 9 0 0 9 87.69 247.93 Tm (. )Tj 0.129 0.129 0.118 rg /T1_0 1 Tf -0.035 Tc 9.4758 0 0 9.5 37.11 236.41 Tm (1986 )Tj 0.2 0.204 0.192 rg 9.338 0 0 9.5 84.37 236.89 Tm (\(12\) )Tj /T1_2 1 Tf 0 Tc 10 0 0 10 153.98 236.41 Tm (5 )Tj ET BT /Suspect <>BDC 0.267 0.267 0.255 rg /T1_0 1 Tf -0.0047 Tc 9.5 0 0 9.5 187.83 236.89 Tm (103-168 )Tj EMC ET BT 0.2 0.204 0.192 rg /T1_0 1 Tf -0.035 Tc 9.4995 0 0 9.5 221.19 236.89 Tm (days )Tj 9.0926 0 0 9.5 260.33 236.89 Tm (1.5 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0277 Tc 9.5 0 0 9.5 301.79 236.89 Tm (57.0\261 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 333.558 237.3745 Tm (4 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.1592 0 0 9.5 361.79 237.37 Tm (60\2613 )Tj EMC ET BT 0.267 0.267 0.255 rg /T1_0 1 Tf -0.035 Tc 6.9507 0 0 8.9 407.07 237.37 Tm (NS )Tj 0.2 0.204 0.192 rg 0.05 Tc 10.3359 0 0 9.5 450.68 237.37 Tm (45\2613 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.3359 0 0 9.5 508.7574 237.37 Tm (40\2613 )Tj EMC /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 8.7564 0 0 9.1 558.6 237.37 Tm (O.ot )Tj EMC ET BT /T1_0 1 Tf 9.1317 0 0 9.5 612.64 237.37 Tm (17 )Tj 0.05 Tc 10.5519 0 0 9.5 623.51 237.37 Tm (\2613 )Tj 10.353 0 0 9.5 680.1 237.37 Tm (23\2616 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.4617 0 0 9.5 730.94 237.85 Tm (0.05 )Tj EMC ET BT /T1_0 1 Tf -0.016 Tc 9.5 0 0 9.5 36.92 214.33 Tm (Present )Tj -0.0173 Tc 3.022 0 Td (study )Tj 0 Tc 9.293 -0.051 Td (8 )Tj -0.0191 Tc 4.126 0.051 Td (12 )Tj -0.0319 Tc 1.144 0 Td (months )Tj -0.035 Tc 9.0926 0 0 9.6 260.81 214.8 Tm (1.5 )Tj 9.2824 0 0 9.5 301.79 214.8 Tm (57)Tj 0.353 0.357 0.345 rg 0 Tc 9.5 0 0 9.5 311.32 214.8 Tm (.)Tj 0.2 0.204 0.192 rg 0.05 Tc 10.247 0 0 9.5 312.92 214.8 Tm (4\2613.2 )Tj 0.129 0.129 0.118 rg 0.0308 Tc 9.5 0 0 9.5 356.04 215.29 Tm (66.6\2612.9 )Tj ET BT /Suspect <>BDC 0.2 0.204 0.192 rg /T1_1 1 Tf -0.035 Tc 7.7494 0 0 9.1 408.37 215.29 Tm (O.Ql )Tj EMC ET BT /T1_0 1 Tf 9.4251 0 0 9.5 444.44 215.29 Tm (44.5 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0427 Tc 9.5 0 0 9.5 462.23 215.29 Tm (\2610.7 )Tj EMC /Suspect <>BDC -0.035 Tc 9.1306 0 0 9.5 502.04 215.29 Tm (40.1 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 519.83 215.29 Tm (\261 )Tj -0.0335 Tc 0.825 0 Td (1.3 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.166 0 0 9.5 559.11 215.29 Tm (0.05 )Tj EMC ET BT /T1_0 1 Tf 9.4183 0 0 9.5 601.59 215.29 Tm (19.65 )Tj 0.267 0.267 0.255 rg 0 Tc 9.5 0 0 9.5 623.51 215.29 Tm (\261 )Tj 0.2 0.204 0.192 rg 0.798 0 Td (3 )Tj -0.035 Tc 8.5945 0 0 9.5 674.1 215.29 Tm (18)Tj 0.353 0.357 0.345 rg 0 Tc 9.5 0 0 9.5 682.84 215.29 Tm (.)Tj 0.2 0.204 0.192 rg 0.05 Tc 11.5336 0 0 9.5 684.35 215.29 Tm (9\2612 )Tj 0.267 0.267 0.255 rg -0.035 Tc 7.3368 0 0 8.9 731.55 215.76 Tm (NS )Tj 0.129 0.129 0.118 rg 9.1986 0 0 9.6 37.42 194.16 Tm (All )Tj -0.0278 Tc 9.5 0 0 9.5 53.26 194.16 Tm (the )Tj ET BT /Suspect <>BDC 0.2 0.204 0.192 rg /T1_0 1 Tf -0.035 Tc 9.0378 0 0 9.5 68.51 194.16 Tm (stUdies )Tj EMC ET BT /T1_0 1 Tf -0.012 Tc 9.5 0 0 9.5 97.82 194.16 Tm (except )Tj -0.0098 Tc 2.989 0 Td (that )Tj 0.0463 Tc 1.862 0 Td (of )Tj -0.0238 Tc 1.268 0 Td (Macnee )Tj /T1_2 1 Tf 0.05 Tc 8.8825 0 0 8.6 188.56 194.16 Tm (et )Tj /T1_3 1 Tf -0.0097 Tc 9 0 0 9 197.65 194.16 Tm (al. )Tj /T1_0 1 Tf -0.035 Tc 9.4347 0 0 9.5 214.07 195.13 Tm (were )Tj -0.0268 Tc 9.5 0 0 9.5 235.59 195.13 Tm (double )Tj -0.0244 Tc 2.992 0 Td (blind. )Tj 0.0399 Tc 8.7 0 0 8.7 288.87 195.13 Tm (Only )Tj -0.035 Tc 9.2014 0 0 9.5 311.98 195.13 Tm (the )Tj 0.0204 Tc 8.7 0 0 8.7 326.86 195.13 Tm (values )Tj 0.0463 Tc 9.5 0 0 9.5 354.15 195.13 Tm (of )Tj -0.0278 Tc 1.271 0 Td (the )Tj -0.0323 Tc 1.659 0 Td (almitrine )Tj -0.0261 Tc 3.842 0 Td (groups )Tj 0.0023 Tc 3.029 0 Td (are )Tj -0.0316 Tc 1.614 0 Td (shown. )Tj ET endstream endobj 106 0 obj <>stream Hd͊zy8 >sRhF^#y QG#Oç==o/ϧ;c_mӷKv|~_oo~y>}~W=|z>{O݇q~?>Ï?o+~ߒ~;%zΏx߽w;>lp?(O?{wٸ^ PZUuTGu^5P5FjFDMԤU PjVjUmFmک]uPuNNE]E5|| _#_k55|| _#_k55|| _#_k55|| _#_k5Z||-_+_kZ||-_+_kZ||-_+_kZ||-_+_ku:||_'_uu:||_'_uu:||_'_uu:||_'_uz||=_/_z||=_/_z||=_/_z||=_/_ || ߀o77 || ߀o77 || ߀o77 || ߀o77 KG#(~? ?G#(~? ?G#(~? ?G#(~? ?z $߄o77MM&|| $߄o77MM&|| $߄o77MM&|| $߄o77MM&||3,ߌo77f||3,ߌo77f||3,ߌo77f||3,ߌo77f|| "߂oȷ[--|| "߂oȷ[--|| "߂oȷ[--|| "߂oȷ[--||+*ߊoŷʷ[V||+*ߊoŷʷ[V||+*ߊoŷʷ[V||+*ߊoŷʷ[V|| &߆o÷ɷmm6|| &߆o÷ɷmm6|| &߆o÷ɷmm6|| 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0.302 0.306 0.29 rg 0.0051 Tc 2.391 0 Td (observed )Tj 0.0279 Tc 4.141 0 Td (after )Tj 0.0181 Tc 2.4 0 Td (one )Tj 0.0242 Tc 1.938 0 Td (year )Tj 0.05 Tc 11.1292 0 0 10.2 258.13 684.73 Tm (of )Tj 0.0054 Tc 10.2 0 0 10.2 271.1 684.73 Tm (almi\255)Tj 0.0137 Tc -20.086 -1.035 Td (trine )Tj 0.0048 Tc 2.45 0 Td (bismesylate )Tj 0.0187 Tc 5.362 0 Td (therapy )Tj 0.0391 Tc 3.618 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.2795 0 0 10.2 197.17 674.17 Tm (COLD )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0169 Tc 10.2 0 0 10.2 232.82 674.17 Tm (patients. )Tj 0.0252 Tc 4.036 0 Td (This )Tj 0.302 0.306 0.29 rg 0.0238 Tc -20.381 -1.083 Td (supports )Tj 0.0072 Tc 4.053 0 Td (its )Tj 0.0088 Tc 1.458 0 Td (long )Tj 0.0182 Tc 2.313 0 Td (term )Tj -0.0304 Tc 2.449 0 Td (use )Tj -0.0079 Tc 1.733 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.2795 0 0 10.2 201.97 663.12 Tm (COLD )Tj EMC ET BT /T1_0 1 Tf 0.0282 Tc 10.2 0 0 10.2 236.18 663.12 Tm (patients )Tj 0.0118 Tc 3.809 0 Td (who )Tj 0.227 0.227 0.216 rg 0.0137 Tc -20.471 -1.035 Td (respond )Tj 0.302 0.306 0.29 rg 0.0253 Tc 3.623 0 Td (to )Tj 0.0029 Tc 1.224 0 Td (the )Tj 0.0227 Tc 1.545 0 Td (drug. )Tj 0.227 0.227 0.216 rg -0.035 Tc 9.7895 0 0 9.8 158.83 627.12 Tm (References )Tj 0.302 0.306 0.29 rg /T1_1 1 Tf 0.05 Tc 8.4915 0 0 8.1 66.56 611.76 Tm (l. )Tj /T1_0 1 Tf 0.0146 Tc 8.3 0 0 8.3 79.67 611.76 Tm (Arnaud )Tj 0 Tc 3.698 0 Td (F)Tj 0.423 0.428 0.412 rg 0.567 0 Td (, )Tj 0.302 0.306 0.29 rg 0.0078 Tc 0.82 0 Td (Bertrand )Tj 0 Tc 4.11 0 Td (A)Tj 0.423 0.428 0.412 rg 0.737 0 Td (, )Tj 0.302 0.306 0.29 rg 0.0261 Tc 0.7 0 Td (Charpin )Tj 0.0053 Tc 3.878 0 Td (J, )Tj 0.0158 Tc 1.153 0 Td (Chretien )Tj 0.0053 Tc 4.052 0 Td (J, )Tj -0.0035 Tc 1.216 0 Td (Decroix )Tj 0.0262 Tc 3.696 0 Td (G, )Tj 0.0146 Tc -26.313 -1.041 Td (Guerrin )Tj 0.05 Tc 8.5832 0 0 8.3 95 603.12 Tm (F, )Tj 0.0281 Tc 8.3 0 0 8.3 105.08 603.12 Tm (Kalb )Tj 0.0166 Tc 2.312 0 Td (JC, )Tj -0.0104 Tc 1.736 0 Td (Lissac )Tj 0 Tc 2.775 0 Td (J)Tj 0.423 0.428 0.412 rg 0.453 0 Td (, )Tj 0.302 0.306 0.29 rg 0.0031 Tc 0.589 0 Td (Michel )Tj 0.05 Tc 8.4154 0 0 8.3 196.28 603.12 Tm (FB)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 206.75 603.12 Tm (, )Tj 0.302 0.306 0.29 rg 0.0269 Tc 0.589 0 Td (Morerc )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 239.4769 603.12 Tm (P)Tj 0.423 0.428 0.412 rg 0.625 0 Td (, )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg 0.0089 Tc 0.531 0 Td (Paramelle )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 285.0688 603.12 Tm (B)Tj 0.423 0.428 0.412 rg 0.683 0 Td (, )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.013 Tc 8.3 0 0 8.3 65.7081 593.9983 Tm (Parient)Tj 0.549 0.549 0.537 rg 0 Tc 2.818 0 Td (.)Tj 0.302 0.306 0.29 rg 0.069 0 Td (c )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.194 0 0 8.3 98.36 594 Tm (R, )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0155 Tc 8.3 0 0 8.3 110.36 594 Tm (Perrin-Fayolle )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0297 Tc 8.3 0 0 8.3 164.1191 594 Tm (M, )Tj 0.227 0.227 0.216 rg 0.0113 Tc 1.793 0 Td (Rochemaure )Tj 0.021 Tc 8.1 0 0 8.1 226.04 594 Tm (J, )Tj 0.302 0.306 0.29 rg -0.0112 Tc 8.3 0 0 8.3 236.14 594 Tm (Voisin )Tj 0 Tc 3.173 0 Td (C)Tj 0.423 0.428 0.412 rg 0.741 0 Td (. )Tj 0.302 0.306 0.29 rg 0.702 0 Td (-)Tj 0.0002 Tc 1.164 0 Td (Le )Tj -0.0029 Tc -26.307 -1.098 Td (bismesilate )Tj 0.0236 Tc 4.616 0 Td (d'almitrine )Tj 0.0092 Tc 4.8 0 Td (dans )Tj -0.035 Tc 7.8836 0 0 8.3 161.69 584.89 Tm (le )Tj 0.0132 Tc 8.3 0 0 8.3 169.9 584.89 Tm (traitement )Tj 0.05 Tc 8.3101 0 0 8.3 206.8 584.89 Tm (au )Tj 0.0103 Tc 8.3 0 0 8.3 217.37 584.89 Tm (long )Tj 0.0276 Tc 2.023 0 Td (cours )Tj -0.035 Tc 8.0093 0 0 8.3 255.27 584.89 Tm (\(6 )Tj -0.0185 Tc 8.3 0 0 8.3 263.98 584.89 Tm (mois\) )Tj -0.0087 Tc 2.48 0 Td (de )Tj -0.0094 Tc -26.37 -1.042 Td (l'insuffisance )Tj 0.0124 Tc 5.386 0 Td [(respiratoire )58(chronique. )]TJ 0.227 0.227 0.216 rg 0.0279 Tc 9.595 0 Td (Etude )Tj 0.302 0.306 0.29 rg 0.015 Tc 2.606 0 Td (multicentrique )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0 Tc 11.1 0 0 11.1 263.4 576.24 Tm (a )Tj EMC ET BT /T1_0 1 Tf 0.013 Tc 8.3 0 0 8.3 269.2 576.24 Tm (double )Tj -0.0123 Tc -24.577 -1.099 Td (insu. )Tj 0.227 0.227 0.216 rg /T1_2 1 Tf 0.018 Tc 8.1 0 0 8.1 84.06 567.12 Tm (Bull )Tj 0.302 0.306 0.29 rg 0.0144 Tc 2.015 0 Td (Eur )Tj 0.0045 Tc 1.896 0 Td (Physiopathol )Tj 0.0081 Tc 5.63 0 Td (Respir, )Tj 0.227 0.227 0.216 rg /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 188.36 567.12 Tm (1982, )Tj 0.302 0.306 0.29 rg -0.0187 Tc 8.3 0 0 8.3 209.47 567.12 Tm (18\(suppl. )Tj 0.227 0.227 0.216 rg -0.0134 Tc 3.906 0 Td (4\), )Tj 0.302 0.306 0.29 rg -0.035 Tc 8.2694 0 0 8.3 253.82 567.12 Tm (373)Tj 0.549 0.549 0.537 rg 0 Tc 8.3 0 0 8.3 265.82 567.12 Tm (-)Tj 0.302 0.306 0.29 rg -0.0313 Tc 0.578 0 Td (382. )Tj 0 Tc -24.746 -1.041 Td (2)Tj 0.423 0.428 0.412 rg 0.506 0 Td (. )Tj 0.302 0.306 0.29 rg 0.0104 Tc 1.23 0 Td (Bourgouin)Tj 0.114 0.114 0.102 rg 0 Tc 4.33 0 Td (-)Tj 0.227 0.227 0.216 rg 0.0227 Tc 0.354 0 Td (Karaouni )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0277 Tc 8.3 0 0 8.3 154.5087 558.4797 Tm (D, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0147 Tc 8.3 0 0 8.3 166.0291 558.4797 Tm (Mercier )Tj 0 Tc 3.584 0 Td (J)Tj 0.423 0.428 0.412 rg 0.453 0 Td (, )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0229 Tc 8.3 0 0 8.3 204.4249 558.4797 Tm (Prefaut )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0122 Tc 8.3 0 0 8.3 232.703 558.4797 Tm (Ch)Tj 0.423 0.428 0.412 rg 0 Tc 1.261 0 Td (. )Tj 0.302 0.306 0.29 rg 0.529 0 Td (-)Tj 0.014 Tc 0.99 0 Td (Long )Tj 0.0077 Tc 2.547 0 Td (term )Tj 0.0044 Tc -25.516 -1.099 Td (studies )Tj 0.0035 Tc 3.186 0 Td (on )Tj 0.0135 Tc 1.388 0 Td (almitrine )Tj -0.0021 Tc 4.175 0 Td (bismesylate )Tj -0.035 Tc 7.9356 0 0 8.3 179.94 549.36 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0438 Tc 8.3 0 0 8.3 189.52 549.36 Tm (COPD )Tj EMC ET BT /T1_0 1 Tf 0.012 Tc 8.3 0 0 8.3 216.0136 549.36 Tm (patients)Tj 0.423 0.428 0.412 rg 0 Tc 3.275 0 Td (. )Tj 0.302 0.306 0.29 rg /T1_2 1 Tf -0.0152 Tc 8.1 0 0 8.1 248.7 549.36 Tm (Eur )Tj /T1_3 1 Tf 0 Tc 7.8001 0 0 7.8001 263.45 549.36 Tm (J )Tj /T1_2 1 Tf 0.0005 Tc 8.1 0 0 8.1 271.26 549.36 Tm (Resplr )Tj -0.035 Tc 8.3534 0 0 8.7 65.36 540.73 Tm (Dis)Tj 0.423 0.428 0.412 rg 0 Tc 8.7 0 0 8.7 76.35 540.73 Tm (, )Tj 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 81.8 540.73 Tm (1986, )Tj -0.0029 Tc 8.3 0 0 8.3 101.66 540.73 Tm (69\(suppl. )Tj 0.227 0.227 0.216 rg -0.035 Tc 8.2069 0 0 8.3 136.52 540.73 Tm (146\), )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0121 Tc 8.3 0 0 8.3 155.42 540.73 Tm (695-701. )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 7.7865 0 0 8.3 65.19 531.61 Tm (3. )Tj 0.0183 Tc 8.3 0 0 8.3 79.16 531.61 Tm (Bourgouin-Karaouni )Tj 0 Tc 8.964 0 Td (D)Tj 0.423 0.428 0.412 rg 0.741 0 Td (, )Tj 0.302 0.306 0.29 rg 0.0245 Tc 0.589 0 Td (Ramonatxo )Tj 0.227 0.227 0.216 rg 0.0282 Tc 5.147 0 Td (M, )Tj 0.302 0.306 0.29 rg -0.0085 Tc 1.446 0 Td (Michel )Tj -0.0045 Tc 3.123 0 Td (FB, )Tj 0.0083 Tc 1.793 0 Td (Macabies )Tj 0.0053 Tc -23.539 -1.1 Td (J, )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0229 Tc 8.3 0 0 8.3 72.437 522.48 Tm (Prefaut )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0122 Tc 8.3 0 0 8.3 99.2792 522.48 Tm (Ch)Tj 0.423 0.428 0.412 rg 0 Tc 1.261 0 Td (.)Tj 0.302 0.306 0.29 rg 0.413 0 Td (-)Tj 0.0067 Tc 0.746 0 Td (Surveillance )Tj 0.0092 Tc 5.28 0 Td (hemodynamiquc )Tj 0.0224 Tc 7 0 Td (pulmonaire )Tj -0.0095 Tc 4.963 0 Td (d'insuffi\255)Tj 0.0128 Tc -23.831 -1.04 Td (sants )Tj 0.0079 Tc 2.384 0 Td (respiratoires )Tj 0.0162 Tc 5.254 0 Td (cbroniques )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0083 Tc 8.3 0 0 8.3 168.4597 513.848 Tm (traites )Tj EMC /Suspect <>BDC /T1_1 1 Tf 0 Tc 11.1 0 0 11.1 191.4 513.85 Tm (a )Tj EMC ET BT /T1_0 1 Tf 0.0245 Tc 8.3 0 0 8.3 197.68 513.85 Tm (double )Tj -0.0102 Tc 3.124 0 Td (insu )Tj 0.0237 Tc 1.976 0 Td (pendant )Tj 0 Tc 3.581 0 Td (4 )Tj 0.0092 Tc 0.753 0 Td (mois )Tj 0.0316 Tc -25.442 -1.1 Td (par )Tj -0.035 Tc 7.8836 0 0 8.3 79.13 504.72 Tm (le )Tj -0.0029 Tc 8.3 0 0 8.3 87.37 504.72 Tm (bismesilate )Tj 0 Tc 4.731 0 Td (d)Tj 0.423 0.428 0.412 rg 0.577 0 Td (')Tj 0.302 0.306 0.29 rg -0.0157 Tc 0.233 0 Td (almit.rine)Tj 0.423 0.428 0.412 rg 0 Tc 3.748 0 Td (. )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_2 1 Tf 0.05 Tc 8.1354 0 0 8.1 169.02 504.72 Tm (Rev )Tj EMC ET BT /T1_2 1 Tf 0.0347 Tc 8.1 0 0 8.1 184.88 504.72 Tm (Mal )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0081 Tc 8.1 0 0 8.1 201.1772 504.72 Tm (Respir, )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 228.2 504.72 Tm (1984, )Tj 6.7123 0 0 8.3 249.37 504.72 Tm (1, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.1639 0 0 8.3 257.23 504.72 Tm (245)Tj 0.549 0.549 0.537 rg 0 Tc 8.3 0 0 8.3 268.7 504.72 Tm (-)Tj 0.302 0.306 0.29 rg -0.035 Tc 8.2652 0 0 8.3 274.03 504.72 Tm (250. )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 64.77 495.61 Tm (4)Tj 0.423 0.428 0.412 rg 0.504 0 Td (. )Tj 0.302 0.306 0.29 rg 0.016 Tc 1.167 0 Td (Castaing )Tj 0 Tc 4.055 0 Td (Y)Tj 0.423 0.428 0.412 rg 0.739 0 Td (, )Tj 0.227 0.227 0.216 rg 0.015 Tc 0.705 0 Td (Manier )Tj 0.302 0.306 0.29 rg 0.0262 Tc 3.407 0 Td (G, )Tj 0.0028 Tc 1.511 0 Td (Varene )Tj 0 Tc 3.361 0 Td (N)Tj 0.423 0.428 0.412 rg 0.731 0 Td (, )Tj 0.302 0.306 0.29 rg 0.0266 Tc 0.7 0 Td (Guenard )Tj 0.0223 Tc 4.111 0 Td (H. )Tj 0.549 0.549 0.537 rg 0 Tc 1.439 0 Td (-)Tj 0.302 0.306 0.29 rg 0.0069 Tc 0.994 0 Td (Almitrine )Tj 0.0121 Tc -23.43 -1.041 Td (orale )Tj 0.05 Tc 8.3173 0 0 8.3 83.91 486.97 Tm (et )Tj 0.0184 Tc 8.3 0 0 8.3 92.56 486.97 Tm (distribution )Tj 0.0036 Tc 5.089 0 Td (des )Tj 0.0279 Tc 1.686 0 Td (rapports )Tj 0 Tc 3.816 0 Td [(V )277(A)]TJ 0.423 0.428 0.412 rg 1.39 0 Td (/)Tj 0.302 0.306 0.29 rg 0.337 0 Td (Q )Tj 0.0285 Tc 1.041 0 Td (dans )Tj -0.0264 Tc 2.199 0 Td (les )Tj 0.0182 Tc 1.398 0 Td (bronchopneumo\255)Tj 0.0023 Tc -20.299 -1.1 Td (pathies )Tj 0.0162 Tc 3.401 0 Td (chroniques )Tj 0.0074 Tc 5.147 0 Td (obstructives. )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_2 1 Tf -0.0018 Tc 8.1 0 0 8.1 184.38 477.84 Tm (Bull )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_2 1 Tf -0.0152 Tc 8.1 0 0 8.1 203.0991 477.84 Tm (Eur )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0184 Tc 8.1 0 0 8.1 220.3764 477.84 Tm (Phy)Tj 0.423 0.428 0.412 rg 0 Tc 1.596 0 Td (s)Tj 0.302 0.306 0.29 rg -0.0128 Tc 0.399 0 Td (iopatlzol )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_2 1 Tf -0.0018 Tc 8.1 0 0 8.1 268.8549 477.84 Tm (Respir, )Tj 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.3701 0 0 8.3 65.51 469.21 Tm (1981)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 80.51 469.21 Tm (, )Tj 0.302 0.306 0.29 rg 0.0195 Tc 0.675 0 Td (17,917)Tj 0.549 0.549 0.537 rg 0 Tc 2.857 0 Td (-)Tj 0.302 0.306 0.29 rg -0.016 Tc 0.522 0 Td (932. )Tj /T1_2 1 Tf -0.035 Tc 7.5657 0 0 7.7 64.72 460.09 Tm (5. )Tj /T1_0 1 Tf -0.0051 Tc 8.3 0 0 8.3 78.64 460.09 Tm (Ccrretelli )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 112.2799 460.09 Tm (P)Tj 0.423 0.428 0.412 rg 0.625 0 Td (, )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg 0.042 Tc 0.527 0 Td (Cru)Tj 0.423 0.428 0.412 rg 0 Tc 1.624 0 Td (z )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0166 Tc 8.3 0 0 8.3 141.0726 460.09 Tm (JC, )Tj 0.0264 Tc 1.736 0 Td (Fahri )Tj -0.006 Tc 2.602 0 Td (LE, )Tj 0.011 Tc 1.908 0 Td (Rahn )Tj 0.227 0.227 0.216 rg 0 Tc 2.487 0 Td (H)Tj 0.423 0.428 0.412 rg 0.852 0 Td (. )Tj 0.549 0.549 0.537 rg 0.529 0 Td (-)Tj 0.302 0.306 0.29 rg 0.017 Tc 0.933 0 Td (Determination )Tj 0.05 Tc 8.9033 0 0 8.3 285.04 460.09 Tm (of )Tj -0.0304 Tc 8.3 0 0 8.3 64.78 451.44 Tm (mixed )Tj 0.0014 Tc 2.949 0 Td (venous )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0 Tc 8.5 0 0 8.5 117.45 451.44 Tm (0)Tj 5.2 0 0 5.2 123.82 449.53 Tm (2 )Tj EMC ET BT /T1_0 1 Tf 0.0358 Tc 8.3 0 0 8.3 131.44 451.44 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.645 0 0 8.3 149.18 451.44 Tm (C0)Tj 0.423 0.428 0.412 rg 0 Tc 5.2 0 0 5.2 161.25 449.53 Tm (2 )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0049 Tc 8.3 0 0 8.3 169.42 451.44 Tm (tensions )Tj 0.0358 Tc 3.81 0 Td (and )Tj 0.0146 Tc 2.082 0 Td (cardiac )Tj 0.0369 Tc 3.528 0 Td (output )Tj -0.035 Tc 8.0386 0 0 8.3 275.53 451.44 Tm (by )Tj 0 Tc 8.3 0 0 8.3 287.92 451.44 Tm (a )Tj 0.0078 Tc -26.883 -1.098 Td (rebreathing )Tj 0.0145 Tc 4.972 0 Td (method)Tj 0.423 0.428 0.412 rg 0 Tc 3.163 0 Td (. )Tj 0.302 0.306 0.29 rg /T1_2 1 Tf 0.0055 Tc 8.1 0 0 8.1 137.34 442.33 Tm (Resp )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0004 Tc 8.1 0 0 8.1 156.0591 442.33 Tm (Physiol, )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 185.96 442.33 Tm (1966, )Tj 0.05 Tc 9.3992 0 0 8.3 206.8 442.33 Tm (l, )Tj 0.0113 Tc 8.3 0 0 8.3 214.99 442.33 Tm (258-264. )Tj -0.035 Tc 7.6478 0 0 8.3 64.23 433.21 Tm (6. )Tj 0.0214 Tc 8.3 0 0 8.3 78.16 433.21 Tm (Chabrillat )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.261 0 0 8.3 116.62 433.21 Tm (Y, )Tj EMC ET BT /T1_0 1 Tf 0.0173 Tc 8.3 0 0 8.3 128.11 433.21 Tm (Jammcs )Tj -0.035 Tc 8.261 0 0 8.3 159.34 433.21 Tm (Y, )Tj -0.0002 Tc 8.3 0 0 8.3 171.33 433.21 Tm (Zwirn )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.019 Tc 8.3 0 0 8.3 195.317 433.21 Tm (P, )Tj EMC ET BT /T1_0 1 Tf 0.0381 Tc 8.3 0 0 8.3 205.8331 433.21 Tm (Gerard )Tj 0.227 0.227 0.216 rg 0.0116 Tc 3.417 0 Td (R. )Tj 0.549 0.549 0.537 rg 0 Tc 1.381 0 Td (-)Tj 0.302 0.306 0.29 rg 0.0157 Tc 1.048 0 Td (Mesure )Tj -0.0079 Tc 3.465 0 Td (du )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.009 Tc 8.3 0 0 8.3 63.7537 424.5614 Tm (debit )Tj EMC ET BT /T1_0 1 Tf 0.0233 Tc 8.3 0 0 8.3 83.9144 424.5614 Tm (cardiaque )Tj 0.05 Tc 8.4273 0 0 8.3 120.49 424.56 Tm (par )Tj 0.0306 Tc 8.3 0 0 8.3 134.88 424.56 Tm (une )Tj 0.0154 Tc 1.848 0 Td (methode )Tj 0.0324 Tc 3.934 0 Td (non )Tj -0.0078 Tc 1.9 0 Td (agressive)Tj 0.423 0.428 0.412 rg 0 Tc 3.69 0 Td (. )Tj 0.227 0.227 0.216 rg 0.0283 Tc 0.593 0 Td (Estimation )Tj 0.302 0.306 0.29 rg 0.0491 Tc 4.854 0 Td (de )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf -0.0095 Tc 8.3 0 0 8.3 285.5416 424.56 Tm (Ia )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0037 Tc 8.3 0 0 8.3 64.33 415.4383 Tm (pression )Tj 0.0056 Tc 4.095 0 Td (arterielle )Tj -0.0087 Tc 4.337 0 Td (de )Tj 0.0149 Tc 12.1 0 0 12.1 148.68 415.44 Tm (col )Tj 0.05 Tc 8.4273 0 0 8.3 170.41 415.44 Tm (par )Tj 0.0133 Tc 8.3 0 0 8.3 188.63 415.44 Tm (reinhalation )Tj 0.05 Tc 5.659 0 Td (du )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.003 Tc 8.3 0 0 8.3 250.9713 415.44 Tm (ga)Tj 0.423 0.428 0.412 rg 0 Tc 0.987 0 Td (z )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0014 Tc 8.3 0 0 8.3 268.7167 415.44 Tm (expire. )Tj 0.0188 Tc -24.635 -1.04 Td (Comparaison )Tj 0.0109 Tc 5.899 0 Td (avec )Tj -0.035 Tc 7.9307 0 0 8.3 131.47 406.81 Tm (Ia )Tj 0.227 0.227 0.216 rg 0.0126 Tc 8.3 0 0 8.3 141.1 406.81 Tm (thermodilution. )Tj 0.302 0.306 0.29 rg /T1_2 1 Tf 0.0061 Tc 8.1 0 0 8.1 197.88 406.81 Tm (Arch )Tj 0.05 Tc 8.2332 0 0 8.1 217.53 406.81 Tm (Mal )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0 Tc 8.1 0 0 8.1 234.56 406.81 Tm (Coeur)Tj 0.423 0.428 0.412 rg 2.512 0 Td (, )Tj EMC /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 260.84 406.81 Tm (1980, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 7.6564 0 0 8.3 281.68 406.81 Tm (73)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 289.31 406.81 Tm (, )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.4195 0 0 8.3 65.02 397.69 Tm (107)Tj 0.549 0.549 0.537 rg 0 Tc 8.3 0 0 8.3 75.74 397.69 Tm (-)Tj 0.302 0.306 0.29 rg -0.035 Tc 7.7728 0 0 8.3 81.33 397.69 Tm (113)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 92.47 397.69 Tm (. )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 8.3 0 0 8.3 64.2334 388.56 Tm (7)Tj 0.423 0.428 0.412 rg 0.453 0 Td (. )Tj 0.227 0.227 0.216 rg -0.0003 Tc 1.23 0 Td (Davis )Tj 0.302 0.306 0.29 rg 0.0294 Tc 2.713 0 Td (CC, )Tj 0.0251 Tc 1.97 0 Td (Jones )Tj 0.227 0.227 0.216 rg 0.0272 Tc 2.719 0 Td (ML, )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0166 Tc 8.3 0 0 8.3 157.7661 388.56 Tm (Sealey )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_0 1 Tf -0.035 Tc 7.6923 0 0 8.3 182.85 388.56 Tm (BJ)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 191.35 388.56 Tm (. )Tj ET BT /Suspect <>BDC 0.549 0.549 0.537 rg /T1_0 1 Tf 8.3 0 0 8.3 196.2221 388.56 Tm (-)Tj EMC ET BT 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0181 Tc 8.3 0 0 8.3 203.966 388.56 Tm (Measurements )Tj 0.302 0.306 0.29 rg 0.05 Tc 9.4598 0 0 8.3 256.71 388.56 Tm (of )Tj 0.0242 Tc 8.3 0 0 8.3 266.8 388.56 Tm (cardiac )Tj 0.0369 Tc -24.463 -1.099 Td (output )Tj -0.009 Tc 3.124 0 Td (in )Tj 0.0003 Tc 1.208 0 Td (seriously )Tj /T1_1 1 Tf 0.0427 Tc 8.1 0 0 8.1 133.28 379.44 Tm (ill )Tj /T1_0 1 Tf 0.0202 Tc 8.3 0 0 8.3 143.05 379.44 Tm (patients )Tj 0.227 0.227 0.216 rg 0.008 Tc 3.642 0 Td (using )Tj 0.302 0.306 0.29 rg 0 Tc 2.593 0 Td (a )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.645 0 0 8.3 201.98 379.44 Tm (C0)Tj /T1_1 1 Tf 0 Tc 5.3001 0 0 5.3001 214.04 377.53 Tm (2 )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0136 Tc 8.3 0 0 8.3 221.27 379.44 Tm (rebreathing )Tj 0.302 0.306 0.29 rg 0.009 Tc 5.088 0 Td (method. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0183 Tc 8.1 0 0 8.1 64.16 370.81 Tm (Chest)Tj 0.423 0.428 0.412 rg 0 Tc 2.275 0 Td (, )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_0 1 Tf -0.035 Tc 7.8965 0 0 8.3 88.05 370.81 Tm (1978)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 103.55 370.81 Tm (, )Tj 0.302 0.306 0.29 rg -0.0344 Tc 0.583 0 Td (73, )Tj -0.035 Tc 7.7728 0 0 8.3 121.65 370.81 Tm (167)Tj 0.549 0.549 0.537 rg 0 Tc 8.3 0 0 8.3 133.34 370.81 Tm (-)Tj 0.302 0.306 0.29 rg -0.035 Tc 8.1261 0 0 8.3 137.96 370.81 Tm (172)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 150.07 370.81 Tm (. )Tj 0.302 0.306 0.29 rg -0.035 Tc 7.7659 0 0 8.3 63.7 361.69 Tm (8. )Tj 0.0043 Tc 8.3 0 0 8.3 77.68 361.69 Tm (Gluskowski )Tj 0 Tc 5.382 0 Td (J)Tj 0.423 0.428 0.412 rg 0.395 0 Td (, )Tj 0.302 0.306 0.29 rg 0.0265 Tc 0.816 0 Td (Gorecka )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 166.0418 361.69 Tm (D)Tj 0.423 0.428 0.412 rg 0.799 0 Td (, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0064 Tc 8.3 0 0 8.3 179.4795 361.69 Tm (Hawrylkiewicz )Tj 0.227 0.227 0.216 rg 0.01 Tc 6.533 0 Td (I, )Tj 0.302 0.306 0.29 rg -0.0085 Tc 1.16 0 Td (Zielinski )Tj 0.227 0.227 0.216 rg /T1_3 1 Tf 0 Tc 7.3001 0 0 7.3001 276.89 361.69 Tm (J)Tj 0.423 0.428 0.412 rg 0.519 0 Td (. )Tj ET BT /Suspect <>BDC 0.549 0.549 0.537 rg /T1_1 1 Tf 7.3001 0 0 7.3001 286.4969 361.69 Tm (-)Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.002 Tc 8.3 0 0 8.3 63.83 353.05 Tm (Acute )Tj -0.0258 Tc 2.708 0 Td (effects )Tj 0.05 Tc 8.9033 0 0 8.3 110.32 353.05 Tm (of )Tj 0.0058 Tc 8.3 0 0 8.3 119.92 353.05 Tm (alrnitrine )Tj 0.0052 Tc 4.049 0 Td (infusion )Tj 0.05 Tc 8.3916 0 0 8.3 184.24 353.05 Tm (on )Tj 0.0237 Tc 8.3 0 0 8.3 195.85 353.05 Tm (pulmonary )Tj 0.0087 Tc 4.913 0 Td (haemodynamics )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 6.1222 0 0 8.3 63.79 343.93 Tm (i.n )Tj EMC ET BT /T1_0 1 Tf 0.013 Tc 8.3 0 0 8.3 72.95 343.93 Tm (normal )Tj 0.0195 Tc 3.237 0 Td (man. )Tj /T1_2 1 Tf 0.018 Tc 8.1 0 0 8.1 119.58 343.93 Tm (Bull )Tj 0.0144 Tc 2.015 0 Td (Eur )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0047 Tc 8.1 0 0 8.1 151.2591 343.93 Tm (Physiopatlzol )Tj EMC /Suspect <>BDC 0.0081 Tc 5.689 0 Td (Respir, )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 224.36 343.93 Tm (1984, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.002 Tc 8.3 0 0 8.3 244.27 343.93 Tm (20)Tj 0.423 0.428 0.412 rg 0 Tc 1.031 0 Td (, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0087 Tc 8.3 0 0 8.3 257.1765 343.93 Tm (313)Tj 0.423 0.428 0.412 rg 0 Tc 1.504 0 Td (-)Tj 0.302 0.306 0.29 rg -0.035 Tc 8.0593 0 0 8.3 274.47 343.93 Tm (317. )Tj -0.0311 Tc 8.3 0 0 8.3 63.27 334.81 Tm (9. )Tj 0.227 0.227 0.216 rg 0.0299 Tc 1.736 0 Td (Grand )Tj 0.302 0.306 0.29 rg 0.0438 Tc 2.578 0 Td (jean )Tj 0 Tc 1.992 0 Td (T)Tj 0.423 0.428 0.412 rg 0.682 0 Td (.)Tj 0.549 0.549 0.537 rg 0.413 0 Td (-)Tj 0.302 0.306 0.29 rg 0.0086 Tc 0.878 0 Td (Une )Tj 0.0073 Tc 1.965 0 Td (microtechnique )Tj 0.05 Tc 6.528 0 Td (du )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0111 Tc 8.3 0 0 8.3 213.0352 334.81 Tm (catheterismc )Tj EMC ET BT /T1_0 1 Tf 0.0233 Tc 8.3 0 0 8.3 257.6726 334.81 Tm (cardiaque )Tj 0.0221 Tc -23.422 -1.042 Td (droit )Tj 0.0144 Tc 2.487 0 Td (applicable )Tj 0.05 Tc 8.3101 0 0 8.3 123.28 326.16 Tm (au )Tj -0.0031 Tc 8.3 0 0 8.3 136.25 326.16 Tm (lit )Tj 0.05 Tc 1.329 0 Td (du )Tj 0.0142 Tc 1.626 0 Td (malade )Tj 0.0131 Tc 3.458 0 Td (sans )Tj 0.0227 Tc 2.26 0 Td (controle )Tj 0.0123 Tc 3.941 0 Td (radioscopique. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0135 Tc 8.1 0 0 8.1 63.68 317.05 Tm (Cardiologia, )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 108.2 317.05 Tm (1968, )Tj -0.0296 Tc 8.3 0 0 8.3 128.05 317.05 Tm (51, )Tj 0.227 0.227 0.216 rg -0.035 Tc 7.7728 0 0 8.3 141.81 317.05 Tm (184)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 153.02 317.05 Tm (-)Tj 0.227 0.227 0.216 rg -0.035 Tc 8.1261 0 0 8.3 158.12 317.05 Tm (192)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 169.75 317.05 Tm (. )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.5202 0 0 8.3 64.06 307.93 Tm (10)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 71.35 307.93 Tm (. )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0163 Tc 8.3 0 0 8.3 81.559 307.93 Tm (Kofman )Tj 0.302 0.306 0.29 rg 0 Tc 8.6 0 0 8.6 115.63 307.93 Tm (J)Tj 0.423 0.428 0.412 rg 0.437 0 Td (, )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf 0.012 Tc 8.3 0 0 8.3 127.16 307.93 Tm (Perrin )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0144 Tc 8.3 0 0 8.3 154.0437 307.93 Tm (Fayolle )Tj 0.227 0.227 0.216 rg 0.0282 Tc 3.759 0 Td (M, )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0112 Tc 8.3 0 0 8.3 201.0466 307.93 Tm (Groenda.ltl )Tj EMC ET BT /T1_0 1 Tf -0.0269 Tc 8.3 0 0 8.3 243.7667 307.93 Tm (C. )Tj 0.549 0.549 0.537 rg 0 Tc 1.675 0 Td (-)Tj 0.302 0.306 0.29 rg 0.0125 Tc 1.225 0 Td (Action )Tj 0.227 0.227 0.216 rg 0.0092 Tc -24.636 -1.042 Td (hemodynamique )Tj 0.302 0.306 0.29 rg 0.05 Tc 7.452 0 Td (du )Tj 0.0028 Tc 1.804 0 Td (bismesilate )Tj 0.0294 Tc 5.136 0 Td (d'almitrine )Tj 0.05 Tc 8.5136 0 0 8.3 225.96 299.28 Tm (sur )Tj 0.227 0.227 0.216 rg -0.035 Tc 7.9307 0 0 8.3 242.83 299.28 Tm (Ia )Tj 0.302 0.306 0.29 rg 0.0145 Tc 8.3 0 0 8.3 254.32 299.28 Tm (circulation )Tj 0.0224 Tc -23.064 -1.099 Td (pulmonaire )Tj -0.0054 Tc 4.963 0 Td (chez )Tj -0.0264 Tc 2.083 0 Td (lcs )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0054 Tc 8.3 0 0 8.3 132.4926 290.1583 Tm (bronchHique )Tj EMC ET BT /T1_0 1 Tf 0.0124 Tc 8.3 0 0 8.3 178.0015 290.1583 Tm (chronique. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 6.9812 0 0 8.1 216.56 290.16 Tm (JJu/1 )Tj EMC ET BT /T1_2 1 Tf -0.0152 Tc 8.1 0 0 8.1 233.34 290.16 Tm (Eur )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0153 Tc 8.1 0 0 8.1 247.7418 290.16 Tm (Physiopathol )Tj EMC ET BT /T1_2 1 Tf -0.0018 Tc 8.1 0 0 8.1 63.4182 281.5335 Tm (Respir, )Tj /T1_0 1 Tf -0.035 Tc 8.1597 0 0 8.3 89.96 281.53 Tm (1982)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 105.47 281.53 Tm (, )Tj 0.302 0.306 0.29 rg -0.0115 Tc 0.617 0 Td (18\(suppl. )Tj -0.0134 Tc 4.022 0 Td (4\), )Tj 0.0193 Tc 1.437 0 Td (353-358)Tj 0.423 0.428 0.412 rg 0 Tc 3.461 0 Td (. )Tj 0.302 0.306 0.29 rg -0.035 Tc 7.3607 0 0 8.3 64.07 272.41 Tm (11. )Tj 0.0146 Tc 8.3 0 0 8.3 81.08 272.41 Tm (Laubic )Tj 0 Tc 3.528 0 Td (M)Tj 0.423 0.428 0.412 rg 0.914 0 Td (, )Tj 0.302 0.306 0.29 rg 0.05 Tc 8.547 0 0 8.3 125.72 272.41 Tm (Diot )Tj 0.227 0.227 0.216 rg 8.5832 0 0 8.3 146.84 272.41 Tm (F. )Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 159.74 272.41 Tm (-)Tj 0.302 0.306 0.29 rg 1.225 0 Td (A )Tj 0.227 0.227 0.216 rg 0.0085 Tc 1.448 0 Td (pharmacological )Tj 0.302 0.306 0.29 rg 0.0287 Tc 7.445 0 Td (study )Tj 0.05 Tc 9.4598 0 0 8.3 267.75 272.41 Tm (of )Tj -0.0016 Tc 8.3 0 0 8.3 280.78 272.41 Tm (the )Tj 0.0067 Tc -26.196 -1.1 Td (respiratory )Tj 0.0229 Tc 4.96 0 Td (stimulant )Tj 0.0116 Tc 4.458 0 Td (action )Tj 0.05 Tc 8.9033 0 0 8.3 167.44 263.28 Tm (of )Tj 0 Tc 8.3 0 0 8.3 178.89 263.28 Tm (S )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0049 Tc 8.3 0 0 8.3 187.6299 263.28 Tm (2620)Tj 0.423 0.428 0.412 rg 0 Tc 1.952 0 Td (. )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_3 1 Tf 8 0 0 8 210.17 263.28 Tm (J )Tj 0.302 0.306 0.29 rg /T1_2 1 Tf -0.0022 Tc 8.1 0 0 8.1 219.42 263.28 Tm (Pharmacol, )Tj /T1_0 1 Tf -0.0242 Tc 8.3 0 0 8.3 262.75 263.28 Tm (1912, )Tj 0 Tc 2.683 0 Td (3)Tj 0.423 0.428 0.412 rg 0.459 0 Td (, )Tj 0.302 0.306 0.29 rg -0.035 Tc 8.2694 0 0 8.3 62.78 254.65 Tm (363)Tj 0.549 0.549 0.537 rg 0 Tc 8.3 0 0 8.3 74.78 254.65 Tm (-)Tj 0.302 0.306 0.29 rg -0.035 Tc 8.0593 0 0 8.3 79.59 254.65 Tm (374. )Tj 7.7937 0 0 8.3 63.57 245.52 Tm (12. )Tj 0.227 0.227 0.216 rg 0.0061 Tc 8.3 0 0 8.3 81.08 245.52 Tm (Macnee )Tj 0.302 0.306 0.29 rg -0.035 Tc 7.9213 0 0 8.3 112.29 245.52 Tm (W. )Tj 0.0361 Tc 8.3 0 0 8.3 126.64 245.52 Tm (Connaughton )Tj 0.227 0.227 0.216 rg 0.0395 Tc 6.249 0 Td (JJ, )Tj 0.302 0.306 0.29 rg 0.0115 Tc 1.736 0 Td (Rhind )Tj -0.0018 Tc 3.118 0 Td (GB, )Tj 0.0317 Tc 2.26 0 Td (Hayhurst )Tj 0.029 Tc 4.453 0 Td (MD, )Tj 0.0259 Tc -25.504 -1.098 Td (Doublas )Tj 0.0424 Tc 3.769 0 Td (NJ, )Tj 0.0312 Tc 1.783 0 Td (Muir )Tj 0.05 Tc 8.7198 0 0 8.3 128.14 236.41 Tm (AL)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 140.03 236.41 Tm (, )Tj 0.302 0.306 0.29 rg -0.0049 Tc 0.647 0 Td (Flenley )Tj 0.0278 Tc 3.239 0 Td (DC. )Tj 0.549 0.549 0.537 rg 0 Tc 2.017 0 Td (-)Tj 0.302 0.306 0.29 rg 0.878 0 Td (A )Tj 0.024 Tc 0.975 0 Td (comparison )Tj 0.05 Tc 9.4598 0 0 8.3 247.11 236.41 Tm (of )Tj -0.0016 Tc 8.3 0 0 8.3 257.26 236.41 Tm (the )Tj -0.0161 Tc 1.495 0 Td (effects )Tj 0.05 Tc 8.9033 0 0 8.3 62.8 227.76 Tm (of )Tj 0.0135 Tc 8.3 0 0 8.3 72.88 227.76 Tm (almitrine )Tj 0.05 Tc 8.9033 0 0 8.3 106.96 227.76 Tm (or )Tj 0.227 0.227 0.216 rg 0.0054 Tc 8.3 0 0 8.3 117.52 227.76 Tm (oxygen )Tj 0.302 0.306 0.29 rg 0.0211 Tc 3.423 0 Td (breathing )Tj 0.227 0.227 0.216 rg 0.05 Tc 8.3916 0 0 8.3 181.36 227.76 Tm (on )Tj 0.302 0.306 0.29 rg 0.0165 Tc 8.3 0 0 8.3 193.93 227.76 Tm (pulmonary )Tj 0.0109 Tc 4.905 0 Td (arterial )Tj 0.013 Tc 3.365 0 Td (pressure )Tj 0.0358 Tc -24.069 -1.098 Td (and )Tj 0.0199 Tc 1.743 0 Td (right )Tj 0.0133 Tc 2.196 0 Td (ventricular )Tj 0.0058 Tc 4.676 0 Td (ejection )Tj 0.0079 Tc 3.412 0 Td (fraction )Tj -0.009 Tc 3.472 0 Td (in )Tj 0.0037 Tc 1.048 0 Td (hypoxic )Tj 0.0245 Tc 3.404 0 Td (chronic )Tj 0.0133 Tc 3.423 0 Td (bronchitis )Tj 0.0069 Tc -23.375 -1.1 Td (and )Tj 0.0032 Tc 1.792 0 Td (emphysema. )Tj 0.227 0.227 0.216 rg /T1_2 1 Tf 0.05 Tc 8.3646 0 0 8.1 123.01 209.52 Tm (Am )Tj 0.0238 Tc 8.1 0 0 8.1 137.82 209.52 Tm (Rev )Tj 0.0123 Tc 1.896 0 Td (Respir )Tj 0.302 0.306 0.29 rg 0.0059 Tc 2.965 0 Td (Dis, )Tj 0.227 0.227 0.216 rg /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 194.12 209.52 Tm (1986, )Tj 0.302 0.306 0.29 rg 7.9309 0 0 8.3 215.25 209.52 Tm (134, )Tj /T1_2 1 Tf -0.0303 Tc 8.1 0 0 8.1 231.28 209.52 Tm (559)Tj 0.423 0.428 0.412 rg 0 Tc 1.543 0 Td (-)Tj 0.302 0.306 0.29 rg -0.0303 Tc 0.531 0 Td (565)Tj 0.423 0.428 0.412 rg 0 Tc 1.541 0 Td (. )Tj 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.3607 0 0 8.3 63.59 200.89 Tm (13. )Tj 0.0266 Tc 8.3 0 0 8.3 80.6 200.89 Tm (Mahler )Tj 0.227 0.227 0.216 rg 0.0287 Tc 3.412 0 Td (DA, )Tj 0.0445 Tc 2.14 0 Td (Matthay )Tj 0.0207 Tc 3.99 0 Td (RA, )Tj 0.302 0.306 0.29 rg 0.0188 Tc 2.069 0 Td (Snyder )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf 0.05 Tc 9.1672 0 0 8.3 203.48 200.89 Tm (PR)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 215.39 200.89 Tm (, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0065 Tc 8.3 0 0 8.3 220.8431 200.89 Tm (Neff )Tj 0.227 0.227 0.216 rg 0.0207 Tc 2.188 0 Td (RK, )Tj 0.302 0.306 0.29 rg 0.0137 Tc 2.14 0 Td (Loke )Tj 0.227 0.227 0.216 rg 0.0053 Tc 2.428 0 Td (J. )Tj 0.302 0.306 0.29 rg 0 Tc 1.035 0 Td (-)Tj 0.017 Tc -26.826 -1.1 Td (Determination )Tj 0.05 Tc 9.4598 0 0 8.3 116.07 191.76 Tm (of )Tj 0.0339 Tc 8.3 0 0 8.3 126.64 191.76 Tm (cardiac )Tj 0.0485 Tc 3.47 0 Td (output )Tj 0.05 Tc 8.8544 0 0 8.3 182.31 191.76 Tm (at )Tj 0.0014 Tc 8.3 0 0 8.3 192.95 191.76 Tm (rest )Tj 0.0358 Tc 1.958 0 Td (and )Tj 0.0234 Tc 1.966 0 Td (during )Tj -0.0101 Tc 3.18 0 Td (exercise )Tj -0.035 Tc 8.0386 0 0 8.3 282.73 191.76 Tm (by )Tj 0.0154 Tc 8.3 0 0 8.3 62.32 182.65 Tm (carbon )Tj 0.0032 Tc 3.181 0 Td (dioxide )Tj 0.0193 Tc 3.42 0 Td (rebreathing )Tj 0.0261 Tc 5.088 0 Td (method )Tj -0.009 Tc 3.464 0 Td (in )Tj 0.015 Tc 1.155 0 Td (obstructive )Tj 0.0138 Tc 4.916 0 Td (airway )Tj 0.0028 Tc 3.123 0 Td (disease)Tj 0.423 0.428 0.412 rg 0 Tc 2.939 0 Td (. )Tj 0.302 0.306 0.29 rg /T1_2 1 Tf 0.05 Tc 8.3646 0 0 8.1 62.53 174.01 Tm (Am )Tj 0.0238 Tc 8.1 0 0 8.1 76.86 174.01 Tm (Rev )Tj 0.0123 Tc 1.896 0 Td (Respir )Tj 0.0059 Tc 2.965 0 Td (Dis, )Tj /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 133.64 174.01 Tm (1985, )Tj 7.4195 0 0 8.3 154.3 174.01 Tm (131)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 165.47 174.01 Tm (, )Tj 0.302 0.306 0.29 rg 0.0319 Tc 0.583 0 Td (73-78. )Tj 0.227 0.227 0.216 rg -0.035 Tc 7.5202 0 0 8.3 63.1 164.89 Tm (14)Tj 0.114 0.114 0.102 rg 0 Tc 8.3 0 0 8.3 70.39 164.89 Tm (. )Tj 0.302 0.306 0.29 rg -0.0011 Tc 1.23 0 Td (Melot )Tj 0.05 Tc 8.3512 0 0 8.3 104.55 164.89 Tm (Ch, )Tj -0.0005 Tc 8.3 0 0 8.3 121.48 164.89 Tm (Naeije )Tj 0.227 0.227 0.216 rg 0.0116 Tc 3.171 0 Td (R, )Tj 0.0138 Tc 1.504 0 Td (Rothchild )Tj 0.05 Tc 8.3129 0 0 8.3 197.69 164.89 Tm (Th, )Tj 0.0055 Tc 8.3 0 0 8.3 214.52 164.89 Tm (Mertens )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0092 Tc 8.3 0 0 8.3 246.6825 164.89 Tm (Ph, )Tj EMC ET BT /T1_0 1 Tf 0.0125 Tc 8.3 0 0 8.3 262.0458 164.89 Tm (Mols )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.019 Tc 8.3 0 0 8.3 283.6424 164.89 Tm (P, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0097 Tc 8.3 0 0 8.3 62.3644 156.2497 Tm (Hallemans )Tj 0.0116 Tc 4.626 0 Td (R. )Tj 0.05 Tc 8.4589 0 0 8.3 110.78 156.25 Tm (-Improvement )Tj 0.0488 Tc 8.3 0 0 8.3 166.01 156.25 Tm (in )Tj 0.0093 Tc 1.047 0 Td (ventilation-perfusion )Tj 0.0232 Tc 8.848 0 Td (matching )Tj -0.0073 Tc 4.11 0 Td (by )Tj 0.0135 Tc -26.555 -1.099 Td (almitrine )Tj -0.035 Tc 7.9356 0 0 8.3 95.46 147.13 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0438 Tc 8.3 0 0 8.3 104.56 147.13 Tm (COPD)Tj 0.549 0.549 0.537 rg 0 Tc 2.823 0 Td (. )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg /T1_2 1 Tf 0.0065 Tc 8.1 0 0 8.1 132.8 147.13 Tm (Chest, )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 7.8965 0 0 8.3 157.65 147.13 Tm (1983)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 172.67 147.13 Tm (, )Tj 0.302 0.306 0.29 rg -0.0002 Tc 0.576 0 Td (83, )Tj -0.035 Tc 7.9095 0 0 8.3 190.93 147.13 Tm (528)Tj 0.549 0.549 0.537 rg 0 Tc 8.3 0 0 8.3 202.46 147.13 Tm (-)Tj 0.302 0.306 0.29 rg -0.035 Tc 8.2534 0 0 8.3 207.25 147.13 Tm (533)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 219.19 147.13 Tm (. )Tj 0.302 0.306 0.29 rg -0.035 Tc 7.7937 0 0 8.3 62.61 138.01 Tm (15. )Tj 0.227 0.227 0.216 rg -0.0005 Tc 8.3 0 0 8.3 80.2 138.01 Tm (Naeije )Tj 0.302 0.306 0.29 rg 0.0116 Tc 2.882 0 Td (R, )Tj 0.0134 Tc 1.214 0 Td (Melot )Tj 0.0309 Tc 2.655 0 Td (C, )Tj 0.227 0.227 0.216 rg 0.0125 Tc 1.277 0 Td (Mols )Tj 0.302 0.306 0.29 rg 0.019 Tc 2.313 0 Td (P, )Tj 0.0097 Tc 1.099 0 Td (Hallemans )Tj 0.227 0.227 0.216 rg 0 Tc 4.626 0 Td (R)Tj 0.423 0.428 0.412 rg 0.683 0 Td (, )Tj 0.302 0.306 0.29 rg 0.011 Tc 0.541 0 Td (Naeije )Tj 0.0111 Tc 2.892 0 Td (N, )Tj 0.0318 Tc 1.258 0 Td (Comil )Tj 0.0169 Tc 2.9 0 Td (A, )Tj -0.0118 Tc -26.561 -1.041 Td (Sergysels )Tj 0.227 0.227 0.216 rg -0.035 Tc 8.194 0 0 8.3 97.88 129.37 Tm (R. )Tj ET BT /Suspect <>BDC 0.423 0.428 0.412 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 110.78 129.37 Tm (-)Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0162 Tc 8.3 0 0 8.3 120.4329 129.37 Tm (Effects )Tj 0.05 Tc 8.9033 0 0 8.3 148.24 129.37 Tm (of )Tj 0.0135 Tc 8.3 0 0 8.3 160.24 129.37 Tm (almitrine )Tj 0.227 0.227 0.216 rg -0.009 Tc 4.281 0 Td (in )Tj 0.302 0.306 0.29 rg 0.0129 Tc 1.387 0 Td (decompensated )Tj 0.227 0.227 0.216 rg 0.0245 Tc 6.882 0 Td (chronic )Tj 0.302 0.306 0.29 rg 0.0125 Tc -24.396 -1.099 Td (respiratory )Tj -0.0188 Tc 4.966 0 Td (insufficiency)Tj 0.423 0.428 0.412 rg 0 Tc 5.019 0 Td (. )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_2 1 Tf 0.018 Tc 8.1 0 0 8.1 150.78 120.25 Tm (Bull )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_2 1 Tf 0.0144 Tc 8.1 0 0 8.1 168.0573 120.25 Tm (Eur )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0097 Tc 8.1 0 0 8.1 184.3788 120.25 Tm (Physiopatlzol )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_2 1 Tf -0.0018 Tc 8.1 0 0 8.1 231.4155 120.25 Tm (Respir, )Tj 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 8.0056 0 0 8.3 259.4 120.25 Tm (1981, )Tj 7.7937 0 0 8.3 281.01 120.25 Tm (17, )Tj 0.0023 Tc 8.3 0 0 8.3 62.59 111.6 Tm (153-161. )Tj 0.227 0.227 0.216 rg -0.035 Tc 7.5202 0 0 8.3 62.62 102.48 Tm (16)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 69.91 102.48 Tm (. )Tj 0.302 0.306 0.29 rg 0.0141 Tc 1.182 0 Td (Neukirch )Tj 0 Tc 4.328 0 Td (F)Tj 0.423 0.428 0.412 rg 0.625 0 Td (, )Tj 0.302 0.306 0.29 rg 0.0074 Tc 0.7 0 Td (Castillon )Tj 0.009 Tc 4.226 0 Td (Du )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.0957 0 0 8.3 176.12 102.48 Tm (Pe)Tj 0.114 0.114 0.102 rg 0 Tc 8.3 0 0 8.3 184.31 102.48 Tm (r)Tj 0.227 0.227 0.216 rg 0.0276 Tc 0.347 0 Td (ron )Tj EMC ET BT /T1_0 1 Tf 0.0282 Tc 8.3 0 0 8.3 203.0016 102.48 Tm (M, )Tj 0.302 0.306 0.29 rg 0.0034 Tc 1.622 0 Td (Verdier )Tj 0.0208 Tc 3.583 0 Td (F, )Tj 0.025 Tc 1.33 0 Td (Drutel )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf 0.019 Tc 8.3 0 0 8.3 283.163 102.48 Tm (P, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0062 Tc 8.3 0 0 8.3 61.885 93.3583 Tm (Legrand )Tj 0 Tc 4.048 0 Td (M)Tj 0.423 0.428 0.412 rg 0.914 0 Td (, )Tj 0.302 0.306 0.29 rg 0.0143 Tc 0.936 0 Td (Botto )Tj 0.227 0.227 0.216 rg 0.022 Tc 2.949 0 Td (MJ, )Tj 0.302 0.306 0.29 rg 0.0055 Tc 2.255 0 Td (Lesobre )Tj 0.0116 Tc 3.875 0 Td (R. )Tj 0.549 0.549 0.537 rg 0 Tc 1.554 0 Td (-)Tj 0.302 0.306 0.29 rg 0.0125 Tc 1.167 0 Td (Action )Tj 0.05 Tc 8.435 0 0 8.3 237.04 93.36 Tm (d'un )Tj 0.0229 Tc 8.3 0 0 8.3 257.64 93.36 Tm (stimulant )Tj 0.0072 Tc -23.582 -1.041 Td (respiratoire )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.047 0 0 8.3 102.63 84.72 Tm (\(S )Tj EMC /Suspect <>BDC -0.0155 Tc 8.3 0 0 8.3 111.79 84.72 Tm (2620\), )Tj EMC ET BT /T1_0 1 Tf 0.0211 Tc 8.3 0 0 8.3 135.279 84.72 Tm (administre )Tj 0.0192 Tc 4.626 0 Td (oralement, )Tj 0.0285 Tc 4.684 0 Td (dans )Tj 0.227 0.227 0.216 rg -0.0264 Tc 2.199 0 Td (les )Tj 0.302 0.306 0.29 rg 0.0219 Tc 1.34 0 Td (bronchopneu-)Tj 0.015 Tc 9.076 78.882 Td (mopathies )Tj 0.0046 Tc 4.677 0 Td (obstructives )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0135 Tc 8.3 0 0 8.3 400.215 739.4406 Tm (\(etude )Tj EMC ET BT /T1_0 1 Tf 0.0065 Tc 8.3 0 0 8.3 424.6751 739.4406 Tm (statistique\). )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.018 Tc 8.1 0 0 8.1 468.54 739.44 Tm (Bull )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_2 1 Tf 0.044 Tc 8.1 0 0 8.1 485.8173 739.44 Tm (Eur )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_2 1 Tf 0.0153 Tc 8.1 0 0 8.1 501.6609 739.44 Tm (Physiopathol )Tj EMC ET BT /T1_2 1 Tf 0.0081 Tc 8.1 0 0 8.1 317.3373 730.3275 Tm (Respir, )Tj /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 344.36 730.33 Tm (1974, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 7.7937 0 0 8.3 365.01 730.33 Tm (10, )Tj EMC /Suspect <>BDC 8.197 0 0 8.3 377.19 730.33 Tm (793)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 389.18 730.33 Tm (-)Tj 0.302 0.306 0.29 rg -0.0096 Tc 0.514 0 Td (800)Tj 0.114 0.114 0.102 rg 0 Tc 1.501 0 Td (. )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.011 Tc 8.3 0 0 8.3 316.9866 721.2083 Tm (17. )Tj 0.0106 Tc 2.165 0 Td (Olszowka )Tj 0.0164 Tc 4.693 0 Td (AJ, )Tj 0.227 0.227 0.216 rg 0.0303 Tc 2.136 0 Td (Rahn )Tj 0.302 0.306 0.29 rg 0.0282 Tc 2.892 0 Td (M, )Tj 0.227 0.227 0.216 rg 0.0264 Tc 1.908 0 Td (Fahri )Tj 0.0229 Tc 2.892 0 Td (LE. )Tj 0.302 0.306 0.29 rg 0 Tc 2.19 0 Td (-)Tj 0.227 0.227 0.216 rg /T1_2 1 Tf -0.035 Tc 8.0886 0 0 8.7 484.4 721.21 Tm (In: )Tj /T1_0 1 Tf 0.0019 Tc 8.3 0 0 8.3 499.64 721.21 Tm (Blood )Tj 0.302 0.306 0.29 rg -0.011 Tc 3.119 0 Td (gases: )Tj 0.0033 Tc -25.092 -1.042 Td (hemoglobin )Tj -0.0102 Tc 5.381 0 Td (base )Tj -0.0317 Tc 2.301 0 Td (excess )Tj 0.05 Tc 8.4599 0 0 8.3 405.51 712.56 Tm (and )Tj 0.0162 Tc 8.3 0 0 8.3 422.86 712.56 Tm (maldistribution. )Tj -0.0163 Tc 8.6 0 0 8.6 482.83 712.56 Tm (Lea )Tj 0.0358 Tc 8.3 0 0 8.3 500.08 712.56 Tm (and )Tj 0.227 0.227 0.216 rg 0.0099 Tc 2.087 0 Td (Febiger, )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0077 Tc 8.3 0 0 8.3 317.2393 703.9197 Tm (Philadelphia, )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 365 703.92 Tm (1973. )Tj 7.7937 0 0 8.3 317.97 694.8 Tm (18. )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0089 Tc 8.3 0 0 8.3 335 694.8 Tm (Paramelle )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.5 0 0 8.5 372.33 694.8 Tm (8)Tj 0.423 0.428 0.412 rg 0.624 0 Td (, )Tj 0.302 0.306 0.29 rg -0.0248 Tc 8.3 0 0 8.3 383.48 694.8 Tm (Levy )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.019 Tc 8.3 0 0 8.3 403.1593 694.8 Tm (P, )Tj EMC /Suspect <>BDC 0.031 Tc 1.214 0 Td (Pirotte )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 440.0777 694.8 Tm (C)Tj 0.423 0.428 0.412 rg 0.683 0 Td [(. )-145(-)]TJ 0.227 0.227 0.216 rg 0.0333 Tc 1.693 0 Td (Long )Tj 0.302 0.306 0.29 rg 0.0269 Tc 2.605 0 Td (term )Tj -0.0052 Tc 2.363 0 Td (follow )Tj -0.0163 Tc 3.076 0 Td (up )Tj 0.05 Tc 9.4598 0 0 8.3 537.99 694.8 Tm (of )Tj 0.0165 Tc 8.3 0 0 8.3 317.29 685.68 Tm (pulmonary )Tj 0.0192 Tc 4.673 0 Td (arterial )Tj 0.0047 Tc 3.249 0 Td (pressure )Tj 0.0078 Tc 3.573 0 Td (evolution )Tj -0.009 Tc 4.166 0 Td (in )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf 0.05 Tc 8.5886 0 0 8.3 455.43 685.68 Tm (COPD )Tj EMC ET BT /T1_0 1 Tf 0.0285 Tc 8.3 0 0 8.3 481.45 685.68 Tm (patients )Tj 0.302 0.306 0.29 rg 0.0104 Tc 3.582 0 Td (treated )Tj 0.227 0.227 0.216 rg -0.0073 Tc 3.127 0 Td (by )Tj 0.302 0.306 0.29 rg 0.0135 Tc -26.555 -1.04 Td (almitrine )Tj -0.0036 Tc 4.29 0 Td (bismesylate. )Tj /T1_2 1 Tf 0.0144 Tc 8.1 0 0 8.1 398.46 677.05 Tm (Eur )Tj /T1_3 1 Tf 0 Tc 7.7 0 0 7.7 415.13 677.05 Tm (J )Tj 0.227 0.227 0.216 rg /T1_2 1 Tf 0.0005 Tc 8.1 0 0 8.1 424.38 677.05 Tm (Respir )Tj 0.302 0.306 0.29 rg -0.0139 Tc 3.262 0 Td (Dis, )Tj /T1_0 1 Tf -0.0242 Tc 8.3 0 0 8.3 469.15 677.05 Tm (1983, )Tj 0.0043 Tc 2.741 0 Td (64\(suppl. )Tj -0.035 Tc 8.2069 0 0 8.3 529.16 677.05 Tm (126\), )Tj 0.0139 Tc 8.3 0 0 8.3 316.7 668.41 Tm (333-336. )Tj -0.035 Tc 7.7937 0 0 8.3 317.49 659.29 Tm (19. )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf -0.0076 Tc 8.3 0 0 8.3 335 659.29 Tm (Powles )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg 0.0224 Tc 3.069 0 Td (ACP, )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_0 1 Tf 0.002 Tc 8.3 0 0 8.3 381.5298 659.29 Tm (Tuxen )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0002 Tc 8.3 0 0 8.3 405.5583 659.29 Tm (DV, )Tj EMC ET BT /T1_0 1 Tf 0.0297 Tc 8.3 0 0 8.3 421.8761 659.29 Tm (Mahood )Tj 0.0005 Tc 3.754 0 Td (CB, )Tj 0.302 0.306 0.29 rg -0.0045 Tc 1.913 0 Td (Pugsley )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0051 Tc 8.3 0 0 8.3 497.1239 659.29 Tm (SO, )Tj EMC ET BT /T1_0 1 Tf 0.0102 Tc 8.3 0 0 8.3 512.0722 659.29 Tm (Campbell )Tj 0.0049 Tc -23.476 -1.099 Td (EJM. )Tj 0.549 0.549 0.537 rg 0 Tc 2.77 0 Td (-)Tj 0.302 0.306 0.29 rg 0.05 Tc 8.5058 0 0 8.3 349.37 650.17 Tm (The )Tj 0.0006 Tc 8.3 0 0 8.3 367.59 650.17 Tm (effect )Tj 0.05 Tc 8.9033 0 0 8.3 390.64 650.17 Tm (of )Tj 0.0107 Tc 8.3 0 0 8.3 402.65 650.17 Tm (intravenously )Tj 0.0157 Tc 6.129 0 Td (administered )Tj 0.0164 Tc 5.957 0 Td (almitrine, )Tj 0 Tc 4.569 0 Td (a )Tj 0.0073 Tc -26.996 -1.041 Td (peripheral )Tj 0.0131 Tc (chemoreceptor )Tj 0.008 Tc 10.688 0 Td (agonist, )Tj 0.05 Tc 8.3916 0 0 8.3 434.32 641.53 Tm (on )Tj 0.021 Tc 8.3 0 0 8.3 445.45 641.53 Tm (patient)Tj 0.423 0.428 0.412 rg 0 Tc 2.818 0 Td (s )Tj 0.302 0.306 0.29 rg 0.0071 Tc 0.649 0 Td (with )Tj 0.0341 Tc 2.016 0 Td (chronic )Tj 0.05 Tc 8.4068 0 0 8.3 518.8 641.53 Tm (air )Tj -0.035 Tc 8.2465 0 0 8.3 530.31 641.53 Tm (flow )Tj 0.0173 Tc 8.3 0 0 8.3 316.72 632.41 Tm (obstruction. )Tj /T1_2 1 Tf 0.05 Tc 8.7132 0 0 8.1 360.61 632.41 Tm (Am )Tj -0.0058 Tc 8.1 0 0 8.1 375.9 632.41 Tm (Rev )Tj 0.0123 Tc 1.837 0 Td (Respir )Tj 0.227 0.227 0.216 rg 0.0059 Tc 2.965 0 Td (Dis, )Tj 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 431.72 632.41 Tm (1983, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0198 Tc 8.3 0 0 8.3 451.87 632.41 Tm (127, )Tj EMC ET BT /T1_0 1 Tf -0.0177 Tc 8.3 0 0 8.3 468.9099 632.41 Tm (284)Tj 0.423 0.428 0.412 rg 0 Tc 1.382 0 Td (-)Tj 0.302 0.306 0.29 rg -0.035 Tc 8.2652 0 0 8.3 485.71 632.41 Tm (289. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.2681 0 0 8.3 316.75 623.76 Tm (20. )Tj EMC /Suspect <>BDC 0.227 0.227 0.216 rg 0.0133 Tc 8.3 0 0 8.3 335 623.76 Tm (Prefaut )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0032 Tc 8.3 0 0 8.3 364.7223 623.76 Tm (Ch. )Tj 0.549 0.549 0.537 rg 0 Tc 2.022 0 Td (-)Tj 0.302 0.306 0.29 rg -0.0162 Tc 1.105 0 Td (Effects )Tj 0.05 Tc 8.9033 0 0 8.3 417.99 623.76 Tm (of )Tj 0.0135 Tc 8.3 0 0 8.3 429.52 623.76 Tm (almitrine )Tj -0.009 Tc 4.281 0 Td (in )Tj 0.0289 Tc 1.387 0 Td (oral )Tj -0.0179 Tc 2.254 0 Td (form )Tj 0.0035 Tc 2.546 0 Td (on )Tj 0.0296 Tc 1.62 0 Td (lung )Tj -0.0044 Tc -25.68 -1.098 Td (exchanges )Tj -0.035 Tc 7.9356 0 0 8.3 354.66 614.65 Tm (in )Tj 0.0202 Tc 8.3 0 0 8.3 364.81 614.65 Tm (patients )Tj -0.0122 Tc 3.699 0 Td (with )Tj 0.0095 Tc 2.198 0 Td (hypercapnic )Tj 0.0245 Tc 5.37 0 Td (chronic )Tj 0.015 Tc 3.586 0 Td (obstructive )Tj 0.227 0.227 0.216 rg 0.0296 Tc 5.033 0 Td (lung )Tj 0.302 0.306 0.29 rg -0.0086 Tc -25.736 -1.042 Td (disease. )Tj /T1_2 1 Tf 0.0238 Tc 8.1 0 0 8.1 345.18 606 Tm (Rev )Tj -0.0164 Tc 1.896 0 Td (Fr )Tj 0.0347 Tc 1.365 0 Td (Mal )Tj 0.227 0.227 0.216 rg 0.0157 Tc 2.012 0 Td (Resp, )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 409.64 606 Tm (1980, )Tj EMC ET BT /T1_0 1 Tf 0.0048 Tc 8.3 0 0 8.3 429.45 606 Tm (8\(suppl\), )Tj 0.0106 Tc 4.031 0 Td (165-175. )Tj -0.035 Tc 8.2681 0 0 8.3 316.75 596.89 Tm (21. )Tj 0.227 0.227 0.216 rg 0.0264 Tc 8.3 0 0 8.3 334.48 596.89 Tm (Quanjer )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0092 Tc 8.3 0 0 8.3 365.7212 596.89 Tm (Ph. )Tj EMC /Suspect <>BDC 0.549 0.549 0.537 rg 0 Tc 1.728 0 Td (-)Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.018 Tc 8.3 0 0 8.3 388.1727 596.89 Tm (Standardized )Tj 0.0103 Tc 5.851 0 Td (lung )Tj 0.009 Tc 2.195 0 Td (function )Tj 0.0055 Tc 3.883 0 Td (testing. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0204 Tc 8.1 0 0 8.1 515.6 596.89 Tm (Dull )Tj EMC ET BT /T1_2 1 Tf 0.05 Tc 8.3377 0 0 8.1 531.9 596.89 Tm (Eur )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0045 Tc 8.1 0 0 8.1 316.86 588.24 Tm (Physiopathol )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_2 1 Tf 0.0123 Tc 8.1 0 0 8.1 362.463 588.24 Tm (Respir)Tj 0.423 0.428 0.412 rg 0 Tc 2.722 0 Td (, )Tj 0.227 0.227 0.216 rg /T1_0 1 Tf -0.035 Tc 7.8965 0 0 8.3 389.49 588.24 Tm (1983)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 404.99 588.24 Tm (, )Tj 0.302 0.306 0.29 rg -0.0105 Tc 0.617 0 Td (19\(suppl )Tj -0.0328 Tc 3.781 0 Td (5\), )Tj 0.032 Tc 1.424 0 Td (1-95. )Tj -0.0083 Tc -16.511 -1.099 Td (22. )Tj 0.227 0.227 0.216 rg 0.0016 Tc 2.257 0 Td (Rigaud )Tj 0.302 0.306 0.29 rg -0.0301 Tc 3.586 0 Td (D, )Tj 0.0272 Tc 1.561 0 Td (Dubois )Tj 0.0208 Tc 3.586 0 Td (F, )Tj 0.227 0.227 0.216 rg 0.0153 Tc 1.446 0 Td (Boutet )Tj 0.302 0.306 0.29 rg 0 Tc 3.237 0 Td (J)Tj 0.423 0.428 0.412 rg 0.511 0 Td (, )Tj 0.227 0.227 0.216 rg 0.0168 Tc 0.82 0 Td (Brambilla )Tj 0.302 0.306 0.29 rg 0.0309 Tc 4.68 0 Td (C, )Tj 0.227 0.227 0.216 rg 0.0013 Tc 1.511 0 Td (Verain )Tj 0.0169 Tc 3.298 0 Td (A, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0047 Tc 8.3 0 0 8.3 316.7693 569.9966 Tm (Pararnelle )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 352.7664 569.9966 Tm (B)Tj 0.423 0.428 0.412 rg 0.62 0 Td [(. )29(-)]TJ 0.227 0.227 0.216 rg 0.05 Tc 8.5058 0 0 8.3 368.57 570 Tm (The )Tj 0.302 0.306 0.29 rg -0.0161 Tc 8.3 0 0 8.3 384.39 570 Tm (effects )Tj 0.05 Tc 8.9033 0 0 8.3 407.92 570 Tm (of )Tj 0.0135 Tc 8.3 0 0 8.3 417.04 570 Tm (almitrlne )Tj 0.0035 Tc 3.99 0 Td (on )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0273 Tc 8.3 0 0 8.3 461.2541 570 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0116 Tc 8.3 0 0 8.3 474.227 570 Tm (regional )Tj 0.0236 Tc 3.635 0 Td (distribution )Tj 0.05 Tc 9.4598 0 0 8.3 316.23 561.36 Tm (of )Tj 0.0072 Tc 8.3 0 0 8.3 325.42 561.36 Tm (ventilation )Tj 0.05 Tc 8.4599 0 0 8.3 363.27 561.36 Tm (and )Tj -0.0009 Tc 8.3 0 0 8.3 378.73 561.36 Tm (perfusion )Tj -0.009 Tc 4.039 0 Td (in )Tj 0.0202 Tc 0.993 0 Td (patients )Tj 0.0071 Tc 3.467 0 Td (with )Tj 0.0183 Tc 2.082 0 Td (respiratory )Tj -0.0059 Tc 4.733 0 Td (failure. )Tj /T1_2 1 Tf 0.0238 Tc 8.1 0 0 8.1 532.38 561.36 Tm (Rev )Tj -0.035 Tc 7.7668 0 0 8.1 316.86 552.24 Tm (Fr )Tj 0.227 0.227 0.216 rg 0.0347 Tc 8.1 0 0 8.1 327.44 552.24 Tm (Mal )Tj 0.302 0.306 0.29 rg 0.0157 Tc 2.012 0 Td (Resp, )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf -0.035 Tc 8.1597 0 0 8.3 365.48 552.24 Tm (1980)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 380.99 552.24 Tm (, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0001 Tc 8.3 0 0 8.3 385.7708 552.24 Tm (8\(suppl\))Tj 0.423 0.428 0.412 rg 0 Tc 3.357 0 Td (, )Tj 0.302 0.306 0.29 rg -0.035 Tc 8.1261 0 0 8.3 418.76 552.24 Tm (183)Tj 0.549 0.549 0.537 rg 0 Tc 8.3 0 0 8.3 429.98 552.24 Tm (-)Tj 0.302 0.306 0.29 rg -0.035 Tc 7.9309 0 0 8.3 435.57 552.24 Tm (193. )Tj 8.2681 0 0 8.3 316.27 543.61 Tm (23. )Tj 0.227 0.227 0.216 rg 0.0153 Tc 8.3 0 0 8.3 334.52 543.61 Tm (Romaldini )Tj 0.302 0.306 0.29 rg 0 Tc 4.684 0 Td (H)Tj 0.423 0.428 0.412 rg 0.857 0 Td (, )Tj 0.302 0.306 0.29 rg 0.0085 Tc 0.589 0 Td (Rodriguez-Roisin )Tj 0.0116 Tc 7.634 0 Td (R, )Tj 0.227 0.227 0.216 rg 0.0166 Tc 1.331 0 Td (Wagner )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.05 Tc 8.7762 0 0 8.3 489.56 543.61 Tm (PO)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 500.99 543.61 Tm (, )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_0 1 Tf -0.0071 Tc 8.3 0 0 8.3 506.3684 543.61 Tm (West )Tj -0.0123 Tc 2.369 0 Td (JB. )Tj 0.549 0.549 0.537 rg 0 Tc 1.671 0 Td (-)Tj 0.302 0.306 0.29 rg 0.0186 Tc -26.943 -1.1 Td (Enhancement )Tj 0.05 Tc 9.4598 0 0 8.3 364.71 534.48 Tm (of )Tj 0.0037 Tc 8.3 0 0 8.3 374.39 534.48 Tm (hypoxic )Tj 0.0165 Tc 3.472 0 Td (pulmonary )Tj 0.227 0.227 0.216 rg 0.0149 Tc 4.739 0 Td (vasoconstriction )Tj 0.302 0.306 0.29 rg -0.0073 Tc 7.059 0 Td (by )Tj 0.0135 Tc 1.261 0 Td (almitrine )Tj -0.009 Tc -23.536 -1.04 Td (in )Tj 0.0273 Tc 1.105 0 Td (the )Tj 0.0173 Tc 1.554 0 Td (dog. )Tj /T1_2 1 Tf 0.05 Tc 8.3646 0 0 8.1 356.77 525.85 Tm (Am )Tj 8.1354 0 0 8.1 371.1 525.85 Tm (Rev )Tj 0.0123 Tc 8.1 0 0 8.1 386.46 525.85 Tm (Respir )Tj 0.0059 Tc 2.965 0 Td (Dis, )Tj /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 427.4 525.85 Tm (1983, )Tj 7.9309 0 0 8.3 448.53 525.85 Tm (128, )Tj 0.0196 Tc 8.3 0 0 8.3 464.11 525.85 Tm (288-293. )Tj 0 Tc 9.48 0 Td (' )Tj -0.035 Tc 8.2681 0 0 8.3 316.27 516.73 Tm (24. )Tj 0.0067 Tc 8.3 0 0 8.3 333.93 516.73 Tm (Shrijen )Tj 0 Tc 3.483 0 Td (F)Tj 0.423 0.428 0.412 rg 0.625 0 Td (, )Tj 0.227 0.227 0.216 rg 0.0141 Tc 0.878 0 Td (Romero-Colomer )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 440.1119 516.73 Tm (P)Tj 0.423 0.428 0.412 rg 0.563 0 Td (. )Tj EMC /Suspect <>BDC 0.549 0.549 0.537 rg 0.76 0 Td (-)Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0002 Tc 8.3 0 0 8.3 460.2643 516.73 Tm (Effets )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0095 Tc 8.3 0 0 8.3 484.326 516.73 Tm (bemodynarniques )Tj EMC ET BT /T1_0 1 Tf 0.0406 Tc 8.3 0 0 8.3 316.2344 507.6083 Tm (d'un )Tj 0.0301 Tc 2.54 0 Td (stimulant )Tj 0.0077 Tc 4.696 0 Td (ventilatoire )Tj 0.0086 Tc 5.369 0 Td (\(almitrine\) )Tj 0.0139 Tc 5.092 0 Td (chez )Tj 0.227 0.227 0.216 rg 0.0036 Tc 2.602 0 Td (des )Tj 0.302 0.306 0.29 rg 0.0159 Tc 2.093 0 Td (pulmonaires )Tj 0.0127 Tc -22.449 -1.041 Td (chroniques. )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_2 1 Tf -0.0204 Tc 8.1 0 0 8.1 358.64 498.97 Tm (Dull )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_2 1 Tf 0.0144 Tc 8.1 0 0 8.1 374.4593 498.97 Tm (Eur )Tj 0.0099 Tc 1.896 0 Td (Physiopathol )Tj 0.227 0.227 0.216 rg 0.0081 Tc 5.689 0 Td (Respir, )Tj 0.302 0.306 0.29 rg -0.0332 Tc 3.353 0 Td (1918, )Tj 0.0187 Tc 2.489 0 Td (14, )Tj /T1_0 1 Tf 0.0121 Tc 8.3 0 0 8.3 496.23 498.97 Tm (775-784. )Tj -0.035 Tc 8.1176 0 0 8.3 316.27 489.84 Tm (25)Tj 0.114 0.114 0.102 rg 0 Tc 8.3 0 0 8.3 324.31 489.84 Tm (. )Tj 0.302 0.306 0.29 rg 0.0025 Tc 1.159 0 Td (Seignalet )Tj 0.0257 Tc 4.114 0 Td (Ch, )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0229 Tc 8.3 0 0 8.3 383.9538 489.84 Tm (Prefaut )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0257 Tc 8.3 0 0 8.3 411.7505 489.84 Tm (Ch, )Tj 0.227 0.227 0.216 rg -0.024 Tc 1.908 0 Td (Gon7.ales )Tj 0.302 0.306 0.29 rg 0.05 Tc 8.4394 0 0 8.3 462.15 489.84 Tm (Ch)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 472.67 489.84 Tm (, )Tj 0.302 0.306 0.29 rg 0.0031 Tc 0.647 0 Td (Michel )Tj 0.227 0.227 0.216 rg 0.0244 Tc 3.239 0 Td (FB. )Tj 0.423 0.428 0.412 rg 0 Tc 1.901 0 Td (-)Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0133 Tc 8.3 0 0 8.3 528.8859 489.84 Tm (Oral )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0135 Tc 8.3 0 0 8.3 315.7668 480.7183 Tm (almitrine )Tj /T1_1 1 Tf -0.0266 Tc 8.1 0 0 8.1 349.28 480.72 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0016 Tc 8.3 0 0 8.3 358.54 480.72 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0278 Tc 8.3 0 0 8.3 371.4963 480.72 Tm (treatment )Tj 0.05 Tc 8.9033 0 0 8.3 406.96 480.72 Tm (of )Tj 0.0149 Tc 8.3 0 0 8.3 416.56 480.72 Tm (chronic )Tj 0.0208 Tc 3.354 0 Td (obstructive )Tj 0.0296 Tc 4.917 0 Td (lung )Tj 0.0028 Tc 2.139 0 Td (disease)Tj 0.423 0.428 0.412 rg 0 Tc 2.939 0 Td (. )Tj 0.302 0.306 0.29 rg /T1_2 1 Tf 0.0238 Tc 8.1 0 0 8.1 531.9 480.72 Tm (Rev )Tj -0.0164 Tc -26.667 -1.065 Td (Fr )Tj 0.05 Tc 8.5076 0 0 8.1 326.49 472.09 Tm (Mal )Tj 0.0009 Tc 8.1 0 0 8.1 343.74 472.09 Tm (Resp, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0242 Tc 8.3 0 0 8.3 364.99 472.09 Tm (1980, )Tj EMC ET BT /T1_0 1 Tf -0.0024 Tc 8.3 0 0 8.3 385.2918 472.09 Tm (8\(suppl\), )Tj 0.0113 Tc 3.945 0 Td (217-224. )Tj -0.035 Tc 8.2681 0 0 8.3 315.79 462.97 Tm (26. )Tj 0.227 0.227 0.216 rg -0.0046 Tc 8.3 0 0 8.3 333.93 462.97 Tm (Scrgysels )Tj 0.0116 Tc 4.004 0 Td (R, )Tj 0.302 0.306 0.29 rg -0.0031 Tc 1.271 0 Td (Etien )Tj 0.0157 Tc 2.371 0 Td (JL, )Tj -0.0001 Tc 1.607 0 Td (Schandevyl )Tj -0.0297 Tc 4.93 0 Td (W, )Tj 0.014 Tc 1.446 0 Td (Willeput )Tj 0.227 0.227 0.216 rg 0.0116 Tc 3.873 0 Td (R, )Tj 0.302 0.306 0.29 rg 0.0055 Tc 1.272 0 Td (Lenders )Tj 0.227 0.227 0.216 rg 0.0277 Tc 3.528 0 Td (D, )Tj 0.0101 Tc -26.484 -1.1 Td (Vachaudez )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0138 Tc 8.3 0 0 8.3 357.0704 453.84 Tm (JP, )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0094 Tc 8.3 0 0 8.3 371.0227 453.84 Tm (Van )Tj 0.302 0.306 0.29 rg 0.0272 Tc 2.133 0 Td (Crombeucq )Tj 0.227 0.227 0.216 rg 0.0166 Tc 5.266 0 Td (JC. )Tj 0.549 0.549 0.537 rg 0 Tc 1.845 0 Td (-)Tj 0.227 0.227 0.216 rg 0.0348 Tc 0.933 0 Td (Functional )Tj 0.302 0.306 0.29 rg 0.0155 Tc 5.025 0 Td (evaluation )Tj 0.05 Tc 8.9033 0 0 8.3 537.04 453.84 Tm (of )Tj -0.035 Tc 8.1423 0 0 8.3 316.31 445.21 Tm (new )Tj 0.0137 Tc 8.3 0 0 8.3 331.6 445.21 Tm (analeptic )Tj 0.0474 Tc 3.933 0 Td (drug )Tj 0.0099 Tc 2.195 0 Td (\(Vectarion\) )Tj 0.227 0.227 0.216 rg -0.009 Tc 4.977 0 Td (in )Tj 0.302 0.306 0.29 rg 0.0285 Tc 0.993 0 Td (patients )Tj -0.0122 Tc 3.583 0 Td (with )Tj 0.0245 Tc 2.016 0 Td (chronic )Tj 0.0021 Tc 3.42 0 Td (hypoxemia )Tj 0.0358 Tc -23.025 -1.099 Td (and )Tj 0.227 0.227 0.216 rg 0.007 Tc 1.917 0 Td (hypercapnia. )Tj 0.302 0.306 0.29 rg /T1_2 1 Tf 0.0434 Tc 8.1 0 0 8.1 378.36 436.09 Tm (Acta )Tj -0.0105 Tc 2.336 0 Td (Tuberc )Tj 0.0088 Tc 3.168 0 Td (Pneumol )Tj 0.227 0.227 0.216 rg -0.0319 Tc 3.914 0 Td (Del, )Tj -0.0184 Tc 2.047 0 Td (1918, )Tj 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0344 Tc 8.3 0 0 8.3 491.42 436.09 Tm (69, )Tj 0.0163 Tc 1.567 0 Td (237-246)Tj 0.423 0.428 0.412 rg 0 Tc 3.455 0 Td (. )Tj 0.302 0.306 0.29 rg -0.035 Tc 8.2681 0 0 8.3 315.79 427.44 Tm (27. )Tj 0.0134 Tc 8.3 0 0 8.3 333.93 427.44 Tm (Simonneau )Tj 0.0262 Tc 4.982 0 Td (G, )Tj 0.017 Tc 1.393 0 Td (Meignan )Tj 0.227 0.227 0.216 rg 0.0282 Tc 4.048 0 Td (M, )Tj 0.0162 Tc 1.504 0 Td (Denjen )Tj 0.302 0.306 0.29 rg 0 Tc 3.358 0 Td (A)Tj 0.423 0.428 0.412 rg 0.737 0 Td (, )Tj 0.227 0.227 0.216 rg 0.0051 Tc 0.647 0 Td (Ratrestin )Tj 0 Tc 3.99 0 Td (B)Tj 0.423 0.428 0.412 rg 0.741 0 Td (, )Tj 0.227 0.227 0.216 rg 0.05 Tc 8.5286 0 0 8.3 516.44 427.44 Tm (Harf )Tj 0.302 0.306 0.29 rg 0.0169 Tc 8.3 0 0 8.3 535.67 427.44 Tm (A, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.025 Tc 8.3 0 0 8.3 315.803 418.3266 Tm (Prost )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.2416 0 0 8.3 337.87 418.33 Tm (JF)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 347.35 418.33 Tm (. )Tj 0.549 0.549 0.537 rg 0.76 0 Td (-)Tj 0.227 0.227 0.216 rg 0.0268 Tc 1.101 0 Td (Cardiopulmonary )Tj 0.302 0.306 0.29 rg -0.0161 Tc 7.922 0 Td (effects )Tj 0.05 Tc 9.4598 0 0 8.3 453.99 418.33 Tm (of )Tj 0 Tc 8.3 0 0 8.3 466 418.33 Tm (a )Tj 0.0021 Tc 1.036 0 Td (single )Tj 0.0289 Tc 2.896 0 Td (oral )Tj 0.0285 Tc 2.14 0 Td (dose )Tj 0.05 Tc 8.9033 0 0 8.3 537.04 418.33 Tm (of )Tj 0.0063 Tc 8.3 0 0 8.3 315.76 409.21 Tm (almitrinc )Tj 0.0429 Tc 4.048 0 Td (at )Tj 0.227 0.227 0.216 rg 0.0206 Tc 1.165 0 Td (rest )Tj 0.302 0.306 0.29 rg 0.0358 Tc 1.842 0 Td (and )Tj 0.0035 Tc 1.908 0 Td (on )Tj -0.0101 Tc 1.387 0 Td (exercise )Tj 0.227 0.227 0.216 rg -0.009 Tc 3.53 0 Td (in )Tj 0.302 0.306 0.29 rg 0.0202 Tc 1.166 0 Td (patients )Tj 0.0071 Tc 3.583 0 Td (with )Tj 0.0037 Tc 2.198 0 Td (hypoxic )Tj 0.0149 Tc 3.577 0 Td (chronic )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0067 Tc 8.3 0 0 8.3 315.7517 400.5614 Tm (airflow )Tj EMC ET BT /T1_0 1 Tf 0.0173 Tc 8.3 0 0 8.3 342.154 400.5614 Tm (obstruction. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0035 Tc 8.1 0 0 8.1 386.72 400.56 Tm (Chest)Tj 0.423 0.428 0.412 rg 0 Tc 2.335 0 Td (, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 8.1597 0 0 8.3 410.6 400.56 Tm (1986)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 426.11 400.56 Tm (, )Tj 0.302 0.306 0.29 rg -0.0291 Tc 0.576 0 Td (89, )Tj 0.0106 Tc 1.602 0 Td (174-179. )Tj -0.0083 Tc -15.528 -1.099 Td (28. )Tj 0.008 Tc 2.195 0 Td (Tenaillon )Tj 0.227 0.227 0.216 rg -0.035 Tc 8.2476 0 0 8.3 369.11 391.44 Tm (A, )Tj 0.302 0.306 0.29 rg 0.0086 Tc 8.3 0 0 8.3 380.6 391.44 Tm (Labroussc )Tj 0.0053 Tc 4.51 0 Td (J, )Tj 0.227 0.227 0.216 rg 0.0163 Tc 0.984 0 Td (Longchal )Tj 0.302 0.306 0.29 rg 0 Tc 4.22 0 Td (J)Tj 0.423 0.428 0.412 rg 0.453 0 Td (, )Tj 0.302 0.306 0.29 rg 0.0252 Tc 0.526 0 Td (Chastrc )Tj -0.0097 Tc 8.5 0 0 8.5 498.67 391.44 Tm (J, )Tj 0.0012 Tc 8.3 0 0 8.3 507.32 391.44 Tm (Lissac )Tj 0.227 0.227 0.216 rg /T1_3 1 Tf -0.035 Tc 7.1074 0 0 7.4001 530.81 391.44 Tm (J. )Tj 0.302 0.306 0.29 rg /T1_1 1 Tf 0 Tc 7.4001 0 0 7.4001 538.97 391.44 Tm (-)Tj 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0414 Tc 8.3 0 0 8.3 315.29 382.81 Tm (The )Tj 0.302 0.306 0.29 rg -0.0225 Tc 1.848 0 Td (effect )Tj 0.05 Tc 9.4598 0 0 8.3 350.31 382.81 Tm (of )Tj 0.0208 Tc 8.3 0 0 8.3 359.44 382.81 Tm (almitrine )Tj /T1_1 1 Tf 0.05 Tc 8.5307 0 0 8.1 392 382.81 Tm (in )Tj /T1_0 1 Tf 0.0257 Tc 8.3 0 0 8.3 400.72 382.81 Tm (acute )Tj 0.0162 Tc 2.428 0 Td (exarcerbation )Tj 0.05 Tc 9.4598 0 0 8.3 469.35 382.81 Tm (of )Tj 0.0245 Tc 8.3 0 0 8.3 478.48 382.81 Tm (chronic )Tj 0.0183 Tc 3.363 0 Td (respiratory )Tj -0.0038 Tc -22.969 -1.099 Td (failure )Tj 0.02 Tc 3.131 0 Td (treated )Tj -0.0073 Tc 3.358 0 Td (by )Tj -0.0016 Tc 1.435 0 Td (artificial )Tj 0.0048 Tc 3.882 0 Td (ventilation. )Tj 0.227 0.227 0.216 rg /T1_2 1 Tf 0.05 Tc 8.1354 0 0 8.1 456.54 373.69 Tm (Rev )Tj 0.302 0.306 0.29 rg 0.0428 Tc 8.1 0 0 8.1 472.86 373.69 Tm (Fr )Tj 0.227 0.227 0.216 rg 0.05 Tc 8.2332 0 0 8.1 485.37 373.69 Tm (Mal )Tj 0.0157 Tc 8.1 0 0 8.1 503.1 373.69 Tm (Resp, )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 526.28 373.69 Tm (1980, )Tj EMC ET BT /T1_0 1 Tf -0.0024 Tc 8.3 0 0 8.3 315.69 364.56 Tm (8\(suppl\), )Tj -0.035 Tc 8.1261 0 0 8.3 348.68 364.56 Tm (177)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 360.38 364.56 Tm (-)Tj 0.302 0.306 0.29 rg -0.035 Tc 8.1261 0 0 8.3 365.48 364.56 Tm (182)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 377.11 364.56 Tm (. )Tj 0.302 0.306 0.29 rg -0.035 Tc 8.2681 0 0 8.3 315.31 355.93 Tm (29. )Tj 0.0094 Tc 8.3 0 0 8.3 333.58 355.93 Tm (Van )Tj 0.227 0.227 0.216 rg 0.0114 Tc 2.195 0 Td (Herwaarden )Tj 0.302 0.306 0.29 rg 0.029 Tc 5.431 0 Td (CLA, )Tj 0.227 0.227 0.216 rg 0.016 Tc 2.839 0 Td (Binkhorst )Tj 0.05 Tc 8.3583 0 0 8.3 457.88 355.93 Tm (RA)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 469.79 355.93 Tm (, )Tj 0.302 0.306 0.29 rg 0.014 Tc 0.763 0 Td (Fennis )Tj 0.05 Tc 8.4103 0 0 8.3 502.03 355.93 Tm (JFM, )Tj 0.035 Tc 8.3 0 0 8.3 524.62 355.93 Tm (Van't )Tj 0.0099 Tc -25.159 -1.099 Td (Laa)Tj 0.114 0.114 0.102 rg 0 Tc 1.507 0 Td (r )Tj 0.302 0.306 0.29 rg -0.035 Tc 8.2476 0 0 8.3 335.99 346.81 Tm (A. )Tj ET BT /Suspect <>BDC 0.549 0.549 0.537 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 348.38 346.81 Tm (-)Tj EMC ET BT 0.227 0.227 0.216 rg /T1_0 1 Tf 0.001 Tc 8.3 0 0 8.3 357.5598 346.81 Tm (Reliability )Tj 0.302 0.306 0.29 rg 0.05 Tc 9.4598 0 0 8.3 396.87 346.81 Tm (of )Tj 0.0242 Tc 8.3 0 0 8.3 407.92 346.81 Tm (cardiac )Tj 0.0369 Tc 3.528 0 Td (output )Tj 0.0173 Tc 3.246 0 Td (measurement )Tj -0.0122 Tc 6.016 0 Td (with )Tj 0.0273 Tc 2.312 0 Td (the )Tj 0.0127 Tc -26.261 -1.099 Td (indirect )Tj 0.0306 Tc 3.358 0 Td (Fick )Tj 0.0056 Tc 2.088 0 Td (principle )Tj 0.0146 Tc 3.805 0 Td (for )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.645 0 0 8.3 404.06 337.69 Tm (C0)Tj 0 Tc 5.5001 0 0 5.5001 415.97 336.25 Tm (1 )Tj EMC ET BT /T1_0 1 Tf 0.0234 Tc 8.3 0 0 8.3 420.88 337.69 Tm (during )Tj -0.0018 Tc 2.89 0 Td (exercise)Tj 0.423 0.428 0.412 rg 0 Tc 3.287 0 Td (. )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_2 1 Tf -0.0089 Tc 8.1 0 0 8.1 476.22 337.69 Tm (Pjliigers )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_2 1 Tf 0.0162 Tc 8.1 0 0 8.1 505.0803 337.69 Tm (Arch, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 526.28 337.69 Tm (1980, )Tj EMC ET BT /T1_0 1 Tf 8.2694 0 0 8.3 315.26 329.05 Tm (385)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 327.23 329.05 Tm (, )Tj 0.302 0.306 0.29 rg 0.0308 Tc 0.588 0 Td (21-25. )Tj ET BT /Suspect <>BDC /C0_0 1 Tf 0 Tc 3.2 0 0 6.24 315.36 319.93 Tm <0033007E002E0020>Tj EMC ET BT /T1_0 1 Tf 0.0121 Tc 8.3 0 0 8.3 333.09 319.93 Tm (Weitzenblum )Tj 0 Tc 5.954 0 Td (E)Tj 0.423 0.428 0.412 rg 0.627 0 Td (, )Tj 0.302 0.306 0.29 rg 0.0189 Tc 0.634 0 Td (Sautegeau )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0169 Tc 8.3 0 0 8.3 431.5114 319.93 Tm (A, )Tj EMC ET BT /T1_0 1 Tf 0.0426 Tc 8.3 0 0 8.3 443.4717 319.93 Tm (Ehrhart )Tj 0.0282 Tc 3.702 0 Td (M, )Tj 0.227 0.227 0.216 rg 0.02 Tc 1.619 0 Td (Mammosser )Tj 0.0282 Tc 5.552 0 Td (M, )Tj 0.302 0.306 0.29 rg 0.0394 Tc -26.313 -1.042 Td (Htrth )Tj 0.0257 Tc 2.713 0 Td (Ch, )Tj -0.0102 Tc 1.971 0 Td (Roegel )Tj -0.035 Tc 8.2744 0 0 8.3 381.55 311.28 Tm (E. )Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 392.54 311.28 Tm (-)Tj 0.227 0.227 0.216 rg 0.0168 Tc 0.99 0 Td (Long-term )Tj 0.302 0.306 0.29 rg 0.026 Tc 4.795 0 Td (course )Tj 0.05 Tc 8.9033 0 0 8.3 466.96 311.28 Tm (of )Tj 0.0237 Tc 8.3 0 0 8.3 477.61 311.28 Tm (pulmonary )Tj 0.0192 Tc 4.963 0 Td (arterial )Tj 0.0047 Tc -24.51 -1.099 Td (pressure )Tj -0.009 Tc 3.634 0 Td (in )Tj 0.0245 Tc 1.098 0 Td (chronic )Tj 0.015 Tc 3.412 0 Td (obstructive )Tj 0.0237 Tc 4.869 0 Td (pulmonary )Tj -0.0003 Tc 4.789 0 Td (disease. )Tj 0.227 0.227 0.216 rg /T1_2 1 Tf 0.05 Tc 8.7132 0 0 8.1 492.13 302.16 Tm (Am )Tj 0.302 0.306 0.29 rg 8.1354 0 0 8.1 506.46 302.16 Tm (Rev )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0005 Tc 8.1 0 0 8.1 522.3 302.16 Tm (Respir )Tj EMC /Suspect <>BDC -0.0139 Tc -25.538 -1.125 Td (Dis, )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 332.36 293.05 Tm (1984, )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf 8.236 0 0 8.3 353 293.05 Tm (130, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0122 Tc 8.3 0 0 8.3 369.03 293.05 Tm (993-998. )Tj -0.035 Tc 7.9784 0 0 8.3 315.27 284.41 Tm (31. )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0121 Tc 8.3 0 0 8.3 333.09 284.41 Tm (Weitzcnblum )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0203 Tc 8.3 0 0 8.3 381.5537 284.41 Tm (E, )Tj 0.0426 Tc 1.272 0 Td (Ehrhart )Tj 0.227 0.227 0.216 rg -0.0297 Tc 3.645 0 Td (M, )Tj 0.302 0.306 0.29 rg -0.0023 Tc 1.49 0 Td (Schweider )Tj 0.227 0.227 0.216 rg 0.0166 Tc 4.581 0 Td (JC, )Tj 0.302 0.306 0.29 rg 0.0394 Tc 1.678 0 Td (Hirth )Tj 0 Tc 2.655 0 Td (C)Tj 0.423 0.428 0.412 rg 0.688 0 Td (, )Tj 0.227 0.227 0.216 rg -0.0102 Tc 0.647 0 Td (Roegel )Tj 0.302 0.306 0.29 rg -0.035 Tc 8.2744 0 0 8.3 315.31 275.28 Tm (E.)Tj 0.549 0.549 0.537 rg 0 Tc 8.3 0 0 8.3 324.86 275.28 Tm (-)Tj 0.302 0.306 0.29 rg -0.0118 Tc 0.931 0 Td (Effets )Tj 0.005 Tc 2.665 0 Td (hemodynarniques )Tj 0.0159 Tc 7.52 0 Td (pulmonaires )Tj 0.0491 Tc 5.367 0 Td (de )Tj 0.0118 Tc 1.331 0 Td (l'almitrine )Tj 0.0073 Tc 4.511 0 Td (intravein\255)Tj -0.0002 Tc -23.54 -1.099 Td (eeusc )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0139 Tc 8.3 0 0 8.3 336.8618 266.1583 Tm (chez )Tj EMC ET BT /T1_0 1 Tf -0.0264 Tc 8.3 0 0 8.3 356.5494 266.1583 Tm (les )Tj 0.0152 Tc 1.571 0 Td (bronchiteux )Tj 0.0162 Tc 5.425 0 Td (chroniqucs )Tj -0.002 Tc 5.033 0 Td (insuffisants )Tj 0.0058 Tc 5.154 0 Td (respiratoires. )Tj /T1_2 1 Tf -0.0006 Tc 8.1 0 0 8.1 314.96 257.53 Tm (Dull )Tj -0.0152 Tc 2.072 0 Td (Eur )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0047 Tc 8.1 0 0 8.1 346.6229 257.53 Tm (Physiopatlzol )Tj EMC /Suspect <>BDC 0.0081 Tc 5.689 0 Td (Respir, )Tj EMC ET BT 0.227 0.227 0.216 rg /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 419.72 257.53 Tm (1982, )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 7.7937 0 0 8.3 440.85 257.53 Tm (18, )Tj EMC ET BT /T1_0 1 Tf 0.0269 Tc 8.3 0 0 8.3 452.55 257.53 Tm (765-774)Tj 0.114 0.114 0.102 rg 0 Tc 3.518 0 Td (. )Tj 0.302 0.306 0.29 rg -0.035 Tc 8.275 0 0 8.3 315.26 248.41 Tm (32)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 323.35 248.41 Tm (. )Tj 0.302 0.306 0.29 rg 0.0138 Tc 1.173 0 Td (Winer )Tj 0.227 0.227 0.216 rg -0.0345 Tc 3.122 0 Td (BJ. )Tj 0.549 0.549 0.537 rg 0 Tc 1.843 0 Td (-)Tj 0.302 0.306 0.29 rg 0.0089 Tc 1.151 0 Td (Statistical )Tj 0.0067 Tc 4.588 0 Td (principles )Tj -0.009 Tc 4.501 0 Td (in )Tj 0.0063 Tc 1.386 0 Td (experimental )Tj 0.227 0.227 0.216 rg -0.0111 Tc 5.842 0 Td (design)Tj 0.423 0.428 0.412 rg 0 Tc 2.649 0 Td (. )Tj 0.302 0.306 0.29 rg 0.0124 Tc -27.223 -1.042 Td (McGraw-Hill)Tj 0.423 0.428 0.412 rg 0 Tc 5.541 0 Td (, )Tj 0.302 0.306 0.29 rg 0.0107 Tc 0.599 0 Td (New )Tj 0.0328 Tc 2.248 0 Td (York, )Tj -0.035 Tc 8.241 0 0 8.3 408.68 239.76 Tm (1971, )Tj -0.0133 Tc 8.3 0 0 8.3 429.13 239.76 Tm (pp. )Tj 0.0189 Tc 1.605 0 Td (518-538)Tj 0.423 0.428 0.412 rg 0 Tc 3.463 0 Td (. )Tj ET BT /Suspect <>BDC 0.227 0.227 0.216 rg /T1_0 1 Tf 0.0209 Tc 8.3 0 0 8.3 315.3204 218.6531 Tm (RESUME: )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 8.1134 0 0 8.3 356.6 218.65 Tm (Le )Tj 0.0037 Tc 8.3 0 0 8.3 368.17 218.65 Tm (bismesylate )Tj 0 Tc 5.136 0 Td (d)Tj 0.423 0.428 0.412 rg 0.519 0 Td (')Tj 0.302 0.306 0.29 rg 0.01 Tc 0.233 0 Td (almitrine, )Tj 0.227 0.227 0.216 rg 0.0416 Tc 4.405 0 Td (un )Tj 0.302 0.306 0.29 rg 0.0134 Tc 1.436 0 Td (agoniste )Tj -0.0254 Tc 3.817 0 Td (des )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0085 Tc 8.3 0 0 8.3 511.1209 218.65 Tm (cbemore)Tj 0.423 0.428 0.412 rg 0 Tc 3.525 0 Td (\255)Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0107 Tc 8.3 0 0 8.3 314.3196 209.52 Tm (cepteurs, )Tj 0.0148 Tc 4.164 0 Td (ameliore )Tj -0.0264 Tc 4.049 0 Td (les )Tj 0.0083 Tc 1.561 0 Td (gaz )Tj -0.0079 Tc 1.849 0 Td (du )Tj 0.0339 Tc 1.499 0 Td (sang )Tj 0.0139 Tc 2.318 0 Td (chez )Tj -0.0264 Tc 2.314 0 Td (les )Tj 0.0144 Tc 1.51 0 Td (malades )Tj 0.0193 Tc 3.81 0 Td (atteints )Tj 0.0491 Tc 3.47 0 Td (de )Tj 0.0246 Tc -26.476 -1.04 Td (bronchopneumopathie )Tj 0.0235 Tc 9.936 0 Td (chronique )Tj 0.015 Tc 4.742 0 Td (obstructive )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0062 Tc 8.3 0 0 8.3 479.888 200.888 Tm (\(BPCO\). )Tj EMC ET BT /T1_0 1 Tf 0.0151 Tc 8.3 0 0 8.3 514.4658 200.888 Tm (Certains )Tj 0.0222 Tc -24.058 -1.1 Td (auteurs )Tj 0.05 Tc 8.4919 0 0 8.3 346 191.76 Tm (ont )Tj 0.0155 Tc 8.3 0 0 8.3 363.76 191.76 Tm (observe )Tj 0.227 0.227 0.216 rg 0.0306 Tc 3.942 0 Td (une )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0076 Tc 8.3 0 0 8.3 414.6307 191.76 Tm (elevation )Tj EMC ET BT /T1_0 1 Tf -0.0087 Tc 8.3 0 0 8.3 452.0803 191.76 Tm (de )Tj 0.227 0.227 0.216 rg -0.035 Tc 7.9307 0 0 8.3 466.51 191.76 Tm (Ia )Tj 0.302 0.306 0.29 rg 0.0046 Tc 8.3 0 0 8.3 478.57 191.76 Tm (pression )Tj 0.0056 Tc 4.153 0 Td (arterielle )Tj 0.0159 Tc -23.873 -1.098 Td (pulmonaire )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0129 Tc 8.3 0 0 8.3 358.4607 182.6466 Tm (\(Ppa\) )Tj EMC /Suspect <>BDC 0.0252 Tc 2.778 0 Td (apres )Tj EMC ET BT /T1_0 1 Tf 0.0036 Tc 8.3 0 0 8.3 404.0775 182.6466 Tm (des )Tj 0.0109 Tc 1.851 0 Td (doses )Tj 0.0121 Tc 2.786 0 Td (uniques )Tj 0 Tc 3.692 0 Td (d)Tj 0.423 0.428 0.412 rg 0.577 0 Td (')Tj 0.302 0.306 0.29 rg 0.0063 Tc 0.29 0 Td (almitrine )Tj -0.0192 Tc 4.219 0 Td (\(A\). )Tj 0.0002 Tc 2.205 0 Td (La )Tj 0.005 Tc -26.365 -1.041 Td (presente )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.028 Tc 8.3 0 0 8.3 345.0313 174.0063 Tm (etude )Tj EMC /Suspect <>BDC 0.0296 Tc 2.546 0 Td (controlee )Tj EMC /Suspect <>BDC -0.0058 Tc 4.23 0 Td (realisee )Tj EMC ET BT /T1_0 1 Tf 0.0021 Tc 8.3 0 0 8.3 428.5542 174.0063 Tm (en )Tj 0.013 Tc 1.273 0 Td (double )Tj 0.0091 Tc 3.124 0 Td (insu )Tj 0.0181 Tc 2.023 0 Td (compare )Tj -0.035 Tc 7.9707 0 0 8.3 514.01 174.01 Tm (les )Tj -0.0233 Tc 8.3 0 0 8.3 525.03 174.01 Tm (effets )Tj 0.227 0.227 0.216 rg 0.0097 Tc -25.32 -1.099 Td (hemodynamiques )Tj 0.302 0.306 0.29 rg -0.0087 Tc 7.914 0 Td (de )Tj 0.227 0.227 0.216 rg 0 Tc 1.712 0 Td (!)Tj 0.423 0.428 0.412 rg 0.311 0 Td (')Tj 0.302 0.306 0.29 rg 0.0197 Tc 0.175 0 Td (administration )Tj 0.0237 Tc 6.835 0 Td (pendant )Tj 0.227 0.227 0.216 rg -0.0163 Tc 4.105 0 Td (un )Tj 0.302 0.306 0.29 rg 0.05 Tc 8.3101 0 0 8.3 503.92 164.89 Tm (an )Tj 0.0491 Tc 8.3 0 0 8.3 518.32 164.89 Tm (de )Tj -0.035 Tc 8.2267 0 0 8.3 533 164.89 Tm (1,5 )Tj 8.1452 0 0 8.3 314.86 155.76 Tm (mg)Tj 0.549 0.549 0.537 rg 0 Tc 8.3 0 0 8.3 324.87 155.76 Tm (f)Tj 0.302 0.306 0.29 rg -0.016 Tc 0.355 0 Td (kg)Tj 0.549 0.549 0.537 rg 0 Tc 0.986 0 Td (/)Tj 0.423 0.428 0.412 rg 0.05 Tc 9.3064 0 0 8.3 338.14 155.76 Tm (jo)Tj 0.302 0.306 0.29 rg 8.7036 0 0 8.3 345.6 155.76 Tm (ur )Tj 0 Tc 8.3 0 0 8.3 356.08 155.76 Tm (a)Tj 0.423 0.428 0.412 rg 0.519 0 Td (')Tj 0.302 0.306 0.29 rg 0.241 0 Td (A )Tj ET BT /Suspect <>BDC 0.423 0.428 0.412 rg /T1_0 1 Tf 12.8 0 0 12.8 371.39 155.76 Tm (a )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0031 Tc 8.3 0 0 8.3 378.16 155.76 Tm (cclle )Tj 0.0406 Tc 2.198 0 Td (d'un )Tj 0 Tc 2.264 0 Td (A )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0162 Tc 8.3 0 0 8.3 424.3329 155.76 Tm (pl)Tj 0.423 0.428 0.412 rg 0 Tc 0.741 0 Td (a)Tj 0.302 0.306 0.29 rg 0.011 Tc 0.463 0 Td (ceb)Tj 0.423 0.428 0.412 rg 0 Tc 1.446 0 Td (o )Tj EMC /Suspect <>BDC 0.865 0 Td (\()Tj 0.302 0.306 0.29 rg 0.354 0 Td (P)Tj 0.423 0.428 0.412 rg 0.519 0 Td (\) )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg -0.035 Tc 8.1991 0 0 9.4 466.35 155.76 Tm (:i )Tj EMC ET BT /T1_0 1 Tf 0.0036 Tc 8.3 0 0 8.3 473.68 155.76 Tm (des )Tj 0.0048 Tc 1.742 0 Td (malades )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0012 Tc 8.3 0 0 8.3 518.8403 155.76 Tm (BPCO. )Tj EMC ET BT 0.423 0.428 0.412 rg /T1_0 1 Tf 0.05 Tc 8.405 0 0 8.3 314.28 147.13 Tm (so)Tj 0.302 0.306 0.29 rg -0.035 Tc 7.9823 0 0 8.3 322.48 147.13 Tm (ot )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0284 Tc 8.3 0 0 8.3 331.59 147.13 Tm (egnl.:m)Tj 0.423 0.428 0.412 rg 0 Tc 2.892 0 Td (e)Tj 0.302 0.306 0.29 rg 0.0359 Tc 0.414 0 Td (nt )Tj EMC /Suspect <>BDC 0.423 0.428 0.412 rg 0.05 Tc 8.387 0 0 8.3 368.56 147.13 Tm (co)Tj 0.302 0.306 0.29 rg -0.0003 Tc 8.3 0 0 8.3 377.26 147.13 Tm (mp)Tj 0.423 0.428 0.412 rg 0 Tc 1.265 0 Td (a)Tj 0.302 0.306 0.29 rg 0.529 0 Td (r)Tj 0.423 0.428 0.412 rg -0.0026 Tc 0.337 0 Td (es )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 404.567 147.13 Tm (l)Tj 0.423 0.428 0.412 rg 0.229 0 Td (e )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0227 Tc 8.3 0 0 8.3 413.2903 147.13 Tm (ben)Tj 0.423 0.428 0.412 rg 0 Tc 1.434 0 Td (e)Tj 0.302 0.306 0.29 rg 0.463 0 Td (f)Tj 0.423 0.428 0.412 rg 0.176 0 Td (i)Tj 0.302 0.306 0.29 rg -0.035 Tc 8.0872 0 0 8.3 432.88 147.13 Tm (ce )Tj EMC ET BT 0.423 0.428 0.412 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 442.48 147.13 Tm (c)Tj 0.302 0.306 0.29 rg 0.464 0 Td (l)Tj 0.423 0.428 0.412 rg 0.289 0 Td (i)Tj 0.302 0.306 0.29 rg 0.239 0 Td (n)Tj 0.423 0.428 0.412 rg 0.513 0 Td (i)Tj 0.302 0.306 0.29 rg 0.0354 Tc 0.23 0 Td (quc )Tj -0.0063 Tc 1.849 0 Td (et )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 481.1663 147.13 Tm (!)Tj 0.549 0.549 0.537 rg 0.311 0 Td (')Tj 0.302 0.306 0.29 rg 0.0055 Tc 0.233 0 Td (am)Tj 0.423 0.428 0.412 rg 0 Tc 1.213 0 Td (e)Tj 0.302 0.306 0.29 rg -0.035 Tc 7.6228 0 0 8.3 499.62 147.13 Tm (li)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 503.92 147.13 Tm (o)Tj 0.302 0.306 0.29 rg 0.023 Tc 0.529 0 Td (rat)Tj 0.423 0.428 0.412 rg -0.009 Tc 1.149 0 Td (io)Tj 0.302 0.306 0.29 rg 0 Tc 0.817 0 Td (n )Tj EMC ET BT /T1_0 1 Tf 0.0036 Tc 8.3 0 0 8.3 531.2768 147.13 Tm (des )Tj ET BT /Suspect <>BDC 0.423 0.428 0.412 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 314.3231 138.0083 Tm (g)Tj 0.302 0.306 0.29 rg -0.035 Tc 7.2801 0 0 8.3 318.17 138.01 Tm (az. )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.3 0 0 8.3 327.76 138.01 Tm (du )Tj 0.423 0.428 0.412 rg 0 Tc 1.325 0 Td (s)Tj 0.302 0.306 0.29 rg 0.0177 Tc 0.352 0 Td (ang. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0179 Tc 8.3 0 0 8.3 359.0178 138.01 Tm (Vingt )Tj EMC ET BT /T1_0 1 Tf 0.0128 Tc 8.3 0 0 8.3 380.1413 138.01 Tm (malad)Tj 0.423 0.428 0.412 rg -0.0026 Tc 2.536 0 Td (es )Tj 0.0037 Tc 1.037 0 Td (so)Tj 0.302 0.306 0.29 rg -0.0219 Tc 0.996 0 Td (nt )Tj ET BT /Suspect <>BDC 0.423 0.428 0.412 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 426.6213 138.01 Tm (e)Tj 0.302 0.306 0.29 rg 0.0481 Tc 0.355 0 Td (mres )Tj EMC /Suspect <>BDC 0.0348 Tc 2.306 0 Td (dan)Tj 0.423 0.428 0.412 rg 0 Tc 1.557 0 Td (s )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg 0.0182 Tc 0.618 0 Td (!'etude)Tj 0.423 0.428 0.412 rg 0 Tc 2.793 0 Td (, )Tj EMC ET BT /T1_0 1 Tf 8.3 0 0 8.3 493.8347 138.01 Tm (c)Tj 0.302 0.306 0.29 rg 0.47 0 Td (t )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.3093 0 0 8.3 502 138.01 Tm (qu)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 511.13 138.01 Tm (i)Tj 0.302 0.306 0.29 rg 0.296 0 Td (n)Tj 0.423 0.428 0.412 rg -0.0078 Tc 0.459 0 Td (ze )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 526.9664 138.01 Tm (l)Tj 0.549 0.549 0.537 rg 0.229 0 Td (')Tj 0.423 0.428 0.412 rg 0.233 0 Td (o)Tj 0.302 0.306 0.29 rg 0.587 0 Td (n)Tj 0.423 0.428 0.412 rg 0.519 0 Td (t )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.003 Tc 8.3 0 0 8.3 314.8599 129.3697 Tm (tcrminee )Tj EMC ET BT 0.423 0.428 0.412 rg /T1_0 1 Tf -0.035 Tc 8.0093 0 0 8.3 345.99 129.37 Tm (\(8 )Tj 0.302 0.306 0.29 rg 0.0348 Tc 8.3 0 0 8.3 354.64 129.37 Tm (dan)Tj 0.423 0.428 0.412 rg 0 Tc 1.557 0 Td (s )Tj 0.302 0.306 0.29 rg -0.035 Tc 7.8836 0 0 8.3 372.89 129.37 Tm (lc )Tj 0.0145 Tc 8.3 0 0 8.3 380.57 129.37 Tm (groupe )Tj 0 Tc 3.13 0 Td (A)Tj 0.549 0.549 0.537 rg 0.795 0 Td (, )Tj 0.423 0.428 0.412 rg 0.467 0 Td (7 )Tj 0.302 0.306 0.29 rg 0.05 Tc 8.4485 0 0 8.3 422.8 129.37 Tm (dan)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 435.72 129.37 Tm (s )Tj 0.302 0.306 0.29 rg 0.642 0 Td (l)Tj 0.423 0.428 0.412 rg 0.229 0 Td (e )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 5.7449 0 0 6.5001 448.76 129.37 Tm (I,'T)Tj 0.423 0.428 0.412 rg 0 Tc 6.5001 0 0 6.5001 455.94 129.37 Tm (O)Tj 0.302 0.306 0.29 rg 0.05 Tc 7.7801 0 0 6.5001 460.8 129.37 Tm (upe )Tj EMC /Suspect <>BDC 0 Tc 8.3 0 0 8.3 475.16 129.37 Tm (P)Tj 0.423 0.428 0.412 rg 0.5 0 Td (})Tj 0.549 0.549 0.537 rg 0.352 0 Td (. )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 8.1134 0 0 8.3 487.16 129.37 Tm (Lc)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 495.24 129.37 Tm (s )Tj 0.302 0.306 0.29 rg 0.0372 Tc 0.584 0 Td (gaz )Tj -0.0079 Tc 1.676 0 Td (du )Tj 0.0146 Tc 1.325 0 Td (sang)Tj 0.423 0.428 0.412 rg 0 Tc 1.849 0 Td (, )Tj 0.302 0.306 0.29 rg -0.035 Tc 7.2653 0 0 8.3 314.82 120.25 Tm (lu )Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 326.38 120.25 Tm (v)Tj 0.302 0.306 0.29 rg 0.0214 Tc 0.454 0 Td (entilat)Tj 0.423 0.428 0.412 rg 0.05 Tc 8.8796 0 0 8.3 350.81 120.25 Tm (io)Tj 0.302 0.306 0.29 rg 0 Tc 8.3 0 0 8.3 358.55 120.25 Tm [(n )-463(m)]TJ 0.423 0.428 0.412 rg 2.017 0 Td (i)Tj 0.302 0.306 0.29 rg 0.05 Tc 8.3862 0 0 8.3 377.75 120.25 Tm (nut)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 388.71 120.25 Tm (e )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 8.1511 0 0 9.4 398.3 120.25 Tm (\(V)Tj 0.423 0.428 0.412 rg 8.5796 0 0 9.4 406.99 120.25 Tm (E\))Tj 0.302 0.306 0.29 rg 0 Tc 9.4 0 0 9.4 415.01 120.25 Tm (. )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 7.2698 0 0 8.3 422.83 120.25 Tm (Ia )Tj 0.0435 Tc 8.3 0 0 8.3 434.41 120.25 Tm (pr)Tj 0.423 0.428 0.412 rg 0 Tc 0.855 0 Td (e)Tj 0.302 0.306 0.29 rg -0.0014 Tc 0.401 0 Td (ssion )Tj 0.423 0.428 0.412 rg 0 Tc 2.781 0 Td (a)Tj 0.302 0.306 0.29 rg 0.529 0 Td (r)Tj 0.423 0.428 0.412 rg 0.404 0 Td (t)Tj 0.302 0.306 0.29 rg 0.05 Tc 8.335 0 0 8.3 477.51 120.25 Tm (er)Tj 0.423 0.428 0.412 rg -0.0099 Tc 8.3 0 0 8.3 484.25 120.25 Tm (ie)Tj 0.302 0.306 0.29 rg -0.0282 Tc 0.694 0 Td (lle )Tj 0.0123 Tc 1.629 0 Td (pulm)Tj 0.423 0.428 0.412 rg 0 Tc 2.071 0 Td (o)Tj 0.302 0.306 0.29 rg 0.587 0 Td (n)Tj 0.423 0.428 0.412 rg 0.512 0 Td (a)Tj 0.302 0.306 0.29 rg 0.0021 Tc 0.464 0 Td (ire )Tj 0 Tc -26.423 -1.1 Td (m)Tj 0.423 0.428 0.412 rg -0.0173 Tc 0.802 0 Td (oye)Tj 0.302 0.306 0.29 rg -0.0136 Tc 1.454 0 Td (nn)Tj 0.423 0.428 0.412 rg 0 Tc 1.031 0 Td (e )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 7.4001 0 0 7.4001 351.23 111.12 Tm (\()Tj 0.302 0.306 0.29 rg -0.0278 Tc 0.384 0 Td (Ppa)Tj 0.423 0.428 0.412 rg 0 Tc 1.757 0 Td (\) )Tj EMC ET BT /T1_0 1 Tf 8.3 0 0 8.3 375.27 111.12 Tm (e)Tj 0.302 0.306 0.29 rg 0.529 0 Td (t )Tj -0.035 Tc 7.8836 0 0 8.3 387.77 111.12 Tm (le )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 399.28 111.12 Tm (d)Tj 0.423 0.428 0.412 rg 0.519 0 Td (e)Tj 0.302 0.306 0.29 rg -0.0017 Tc 0.475 0 Td (bit )Tj EMC ET BT 0.423 0.428 0.412 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 422.3208 111.12 Tm (c)Tj 0.302 0.306 0.29 rg 0.0326 Tc 0.405 0 Td (ard)Tj 0.423 0.428 0.412 rg 0 Tc 1.331 0 Td (i)Tj 0.302 0.306 0.29 rg 0.0112 Tc 0.346 0 Td (aque )Tj ET BT /Suspect <>BDC 0.423 0.428 0.412 rg /T1_0 1 Tf 0 Tc 7.8001 0 0 7.8001 461.67 111.12 Tm (\()Tj 0.302 0.306 0.29 rg 0.05 Tc 8.449 0 0 7.8001 464.56 111.12 Tm (Qc)Tj 0.423 0.428 0.412 rg 0 Tc 7.8001 0 0 7.8001 474.19 111.12 Tm (\) )Tj EMC ET BT /T1_0 1 Tf 8.3 0 0 8.3 482.32 111.12 Tm (o)Tj 0.302 0.306 0.29 rg 0.0359 Tc 0.587 0 Td (nt )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.9571 0 0 8.3 499.59 111.12 Tm (et)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 505.84 111.12 Tm (c )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg -0.0094 Tc 1.164 0 Td (mesurc)Tj 0.423 0.428 0.412 rg 0 Tc 2.88 0 Td (s )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0135 Tc 8.3 0 0 8.3 314.4171 102.4797 Tm (peri)Tj 0.423 0.428 0.412 rg 0 Tc 1.551 0 Td (o)Tj 0.302 0.306 0.29 rg 0.0123 Tc 0.52 0 Td (diqucment. )Tj -0.0189 Tc 5.21 0 Td (Ppa )Tj -0.0063 Tc 1.96 0 Td (et )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9.8 0 0 9.8 401.66 102.48 Tm (Q)Tj 0.423 0.428 0.412 rg 0.588 0 Td (c )Tj EMC ET BT /T1_0 1 Tf 0.0037 Tc 8.3 0 0 8.3 415.08 102.48 Tm (so)Tj 0.302 0.306 0.29 rg 0.0359 Tc 0.939 0 Td (nt )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0085 Tc 8.3 0 0 8.3 433.9127 102.48 Tm (reste)Tj 0.423 0.428 0.412 rg 0 Tc 1.837 0 Td (s )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg 0.0153 Tc 0.874 0 Td (inchang)Tj 0.423 0.428 0.412 rg -0.035 Tc 8.0284 0 0 8.3 483.28 102.48 Tm (es )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg 0.0348 Tc 8.3 0 0 8.3 493.36 102.48 Tm (dan)Tj 0.423 0.428 0.412 rg 0 Tc 1.499 0 Td (s )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.8836 0 0 8.3 513.53 102.48 Tm (le)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 518.76 102.48 Tm (s )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 8.3 0 0 8.3 525.9976 102.48 Tm (d)Tj 0.423 0.428 0.412 rg 0.519 0 Td (e)Tj 0.302 0.306 0.29 rg -0.035 Tc 7.9635 0 0 8.3 534.24 102.48 Tm (ux )Tj EMC ET BT /T1_0 1 Tf -0.0087 Tc 8.3 0 0 8.3 314.33 93.36 Tm (gr)Tj 0.423 0.428 0.412 rg 0 Tc 0.808 0 Td (o)Tj 0.302 0.306 0.29 rg 0.0017 Tc 0.588 0 Td (upe)Tj 0.651 0.651 0.639 rg 0 Tc 1.318 0 Td (-)Tj 0.423 0.428 0.412 rg 0.113 0 Td (s)Tj 0.549 0.549 0.537 rg 0.457 0 Td (. )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0356 Tc 8.3 0 0 8.3 348.9161 93.36 Tm (Par )Tj EMC ET BT 0.423 0.428 0.412 rg /T1_0 1 Tf 0.0024 Tc 8.3 0 0 8.3 365.1924 93.36 Tm (co)Tj 0.302 0.306 0.29 rg 0.0232 Tc 0.992 0 Td (ntre )Tj 0.0035 Tc 2.313 0 Td (nou)Tj 0.423 0.428 0.412 rg 0 Tc 1.548 0 Td [(s )-349(a)]TJ 0.302 0.306 0.29 rg -0.011 Tc 1.516 0 Td (vons )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0254 Tc 8.3 0 0 8.3 438.7055 93.36 Tm (note )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 458.3184 93.36 Tm (d)Tj 0.423 0.428 0.412 rg 0.52 0 Td (a)Tj 0.302 0.306 0.29 rg 0.587 0 Td (n)Tj 0.423 0.428 0.412 rg 0.449 0 Td (s )Tj 0.302 0.306 0.29 rg -0.035 Tc 7.8836 0 0 8.3 479.93 93.36 Tm (le )Tj 0.0261 Tc 8.3 0 0 8.3 490.01 93.36 Tm (groupe )Tj 0 Tc 3.477 0 Td (A )Tj -0.0272 Tc 1.389 0 Td (unc )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0055 Tc 8.3 0 0 8.3 314.3156 84.7197 Tm (am)Tj 0.423 0.428 0.412 rg 0 Tc 1.213 0 Td (e)Tj 0.302 0.306 0.29 rg -0.035 Tc 7.6228 0 0 8.3 328.26 84.72 Tm (li)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 332.56 84.72 Tm (o)Tj 0.302 0.306 0.29 rg 0.0194 Tc 0.529 0 Td (rati)Tj 0.423 0.428 0.412 rg 0 Tc 1.437 0 Td (o)Tj 0.302 0.306 0.29 rg 0.587 0 Td (n )Tj EMC ET BT 0.423 0.428 0.412 rg /T1_0 1 Tf 8.3 0 0 8.3 360.3982 84.72 Tm (c)Tj 0.302 0.306 0.29 rg -0.0005 Tc 0.464 0 Td (liniqu)Tj 0.423 0.428 0.412 rg 0 Tc 2.369 0 Td [(e )-112(s)]TJ 0.302 0.306 0.29 rg 0.05 Tc 8.3101 0 0 8.3 393.52 84.72 Tm (an)Tj 0.423 0.428 0.412 rg 0 Tc 8.3 0 0 8.3 402.12 84.72 Tm (s )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.033 Tc 8.3 0 0 8.3 407.9217 84.72 Tm (cffet )Tj EMC ET BT 0.423 0.428 0.412 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 425.1608 84.72 Tm (s)Tj 0.302 0.306 0.29 rg 0.0012 Tc 0.351 0 Td (ec)Tj 0.423 0.428 0.412 rg 0 Tc 0.869 0 Td (o)Tj 0.302 0.306 0.29 rg -0.0136 Tc 0.587 0 Td (nd)Tj 0.423 0.428 0.412 rg 0 Tc 1.033 0 Td (a)Tj 0.302 0.306 0.29 rg 0.0423 Tc 0.464 0 Td (ir)Tj 0.423 0.428 0.412 rg 0 Tc 0.634 0 Td (e )Tj 0.302 0.306 0.29 rg 0.05 Tc 8.3173 0 0 8.3 464.07 84.72 Tm (et )Tj ET BT /Suspect <>BDC 0.423 0.428 0.412 rg /T1_0 1 Tf 8.4039 0 0 8.3 473.16 84.72 Tm (sa)Tj 0.302 0.306 0.29 rg 0.0396 Tc 8.3 0 0 8.3 480.47 84.72 Tm (ns )Tj EMC ET BT /T1_0 1 Tf 0.0122 Tc 8.3 0 0 8.3 490.4798 84.72 Tm (changement )Tj -0.0087 Tc 5.263 0 Td (de )Tj ET endstream endobj 113 0 obj <>stream Hd͊zy8 >sRhF^#y QG#Oç==o/ϧ;c_mӷKv|~_oo~y>}~W=|z>{O݇q~?>Ï?o+~ߒ~;%zΏx߽w;>lp?(O?{wٸ^ PZUuTGu^5P5FjFDMԤU PjVjUmFmک]uPuNNE]E5|| _#_k55|| _#_k55|| _#_k55|| 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