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96.24 578.65 Tm ([13]. )Tj 0.0291 Tc 10.2 0 0 10.2 121.4 578.65 Tm (Functional )Tj -0.0176 Tc 5.226 0 Td (res)Tj 0.161 0.161 0.149 rg 0 Tc 1.17 0 Td (i)Tj 0.286 0.29 0.275 rg 0.0257 Tc 0.233 0 Td (dual )Tj 0.0252 Tc 2.447 0 Td (capacity )Tj 0.0134 Tc 4.141 0 Td (and )Tj 0.0448 Tc -20.753 -1.035 Td (other )Tj 0.0219 Tc 2.584 0 Td (subd)Tj 0.161 0.161 0.149 rg 0 Tc 1.982 0 Td (i)Tj 0.286 0.29 0.275 rg 0.0073 Tc 0.241 0 Td (visions )Tj 0.05 Tc 11.1292 0 0 10.2 126.61 568.09 Tm (of )Tj 0.0277 Tc 10.2 0 0 10.2 139.18 568.09 Tm (total )Tj 0.0245 Tc 2.299 0 Td (lung )Tj 0.0185 Tc 2.164 0 Td (capacity )Tj -0.0181 Tc 3.868 0 Td (were )Tj 0.0049 Tc 2.258 0 Td (meas\255)Tj 0.02 Tc -19.857 -1.082 Td (ured )Tj -0.035 Tc 10.0482 0 0 10.2 67.69 557.05 Tm (by )Tj 0.223 0.223 0.212 rg 0.0029 Tc 10.2 0 0 10.2 81.1 557.05 Tm (the )Tj 0.286 0.29 0.275 rg 0.0018 Tc 1.545 0 Td (closed )Tj 0.0176 Tc 2.918 0 Td (circuit )Tj 0.0321 Tc 2.973 0 Td (method )Tj 0.0056 Tc 3.483 0 Td (with )Tj -0.0081 Tc 2.212 0 Td 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1.588 0 Td (single-breath )Tj 0.0343 Tc -16.937 -1.081 Td (carbon )Tj 0.0145 Tc 3.349 0 Td (monoxide )Tj 0.0227 Tc 4.518 0 Td (method )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0209 Tc 10.2 0 0 10.2 161.1566 502.341 Tm (\(TICO,S)Tj 0.161 0.161 0.149 rg 0 Tc 3.63 0 Td (B)Tj 0.286 0.29 0.275 rg 0.611 0 Td (\) )Tj EMC ET BT /T1_1 1 Tf 0.0116 Tc 10.2 0 0 10.2 212.1566 502.341 Tm (using )Tj 0.0216 Tc 2.633 0 Td (transfer )Tj 0.0094 Tc -19.059 -1.036 Td (test )Tj 0.0346 Tc 1.78 0 Td (apparatus )Tj 0.0216 Tc 4.469 0 Td (\(Morgan\). )Tj 0.223 0.223 0.212 rg 0.05 Tc 10.2656 0 0 10.2 155.91 491.76 Tm (The )Tj 0.286 0.29 0.275 rg -0.001 Tc 10.2 0 0 10.2 176.56 491.76 Tm (initial )Tj 0.0195 Tc 2.727 0 Td (alveolar )Tj 0.0343 Tc 3.671 0 Td (carbon )Tj 0.0212 Tc -19.38 -1.082 Td (monoxide )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0118 Tc 10.2 0 0 10.2 88.687 480.7236 Tm (\(CO\) )Tj EMC ET BT /T1_1 1 Tf 0.031 Tc 10.2 0 0 10.2 112.2286 480.7236 Tm (concentration )Tj 0.0017 Tc 6.032 0 Td (was )Tj 0.0183 Tc 1.825 0 Td (estimated )Tj 0.0048 Tc 4.235 0 Td (from )Tj 0.0265 Tc 2.268 0 Td (the )Tj 0.223 0.223 0.212 rg 0.013 Tc -20.994 -1.081 Td (inspired )Tj ET BT /Suspect <>BDC 0.286 0.29 0.275 rg /T1_1 1 Tf 0.0454 Tc 10.2 0 0 10.2 81.9754 469.6974 Tm (CO )Tj EMC ET BT /T1_1 1 Tf 0.0271 Tc 10.2 0 0 10.2 100.7026 469.6974 Tm (concentration )Tj 0.0185 Tc 6.163 0 Td (\(0.28%\) )Tj 0.0168 Tc 3.767 0 Td (adjusted )Tj 0.0192 Tc 3.905 0 Td (for )Tj 0.0265 Tc 1.656 0 Td (the )Tj 0.0212 Tc -21.043 -1.036 Td (dilution )Tj -0.035 Tc 9.9195 0 0 10.2 82.48 459.12 Tm (in )Tj 0.0029 Tc 10.2 0 0 10.2 95.5 459.12 Tm (the )Tj 0.0402 Tc 1.687 0 Td (lung )Tj 0.05 Tc 11.1292 0 0 10.2 136.69 459.12 Tm (of )Tj 0.0107 Tc 10.2 0 0 10.2 150.71 459.12 Tm (helium )Tj -0.0079 Tc 3.287 0 Td (in )Tj 0.0265 Tc 1.276 0 Td (the )Tj 0.0094 Tc 1.788 0 Td (test )Tj 0.0251 Tc 1.876 0 Td (inspirate )Tj 0.0059 Tc -18.686 -1.081 Td (\(14% )Tj 0.223 0.223 0.212 rg 0.0226 Tc 2.548 0 Td (He )Tj 0.286 0.29 0.275 rg -0.035 Tc 9.9195 0 0 10.2 85.36 448.09 Tm (in )Tj 0.0055 Tc 10.2 0 0 10.2 95.9 448.09 Tm (air\). )Tj 0.05 Tc 10.2656 0 0 10.2 115.59 448.09 Tm (The )Tj -0.0152 Tc 10.2 0 0 10.2 135.25 448.09 Tm (final )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0454 Tc 10.2 0 0 10.2 156.8536 448.09 Tm (CO )Tj EMC ET BT /T1_1 1 Tf 0.031 Tc 10.2 0 0 10.2 173.6632 448.09 Tm (concentration )Tj 0.0017 Tc 6.079 0 Td (was )Tj 0.0351 Tc 1.881 0 Td (that )Tj 0.161 0.161 0.149 rg 0 Tc -20.665 -1.082 Td (i)Tj 0.286 0.29 0.275 rg 0.289 0 Td (n )Tj 0.05 Tc 10.2654 0 0 10.2 59.9 437.05 Tm (an )Tj 0.0127 Tc 10.2 0 0 10.2 78.62 437.05 Tm (alveolar )Tj 0.0228 Tc 4.09 0 Td (sample )Tj 0.05 Tc 11.1292 0 0 10.2 158.29 437.05 Tm (of )Tj ET BT /Suspect <>BDC 0.223 0.223 0.212 rg /T1_1 1 Tf -0.026 Tc 10.2 0 0 10.2 175.09 437.05 Tm (0.7 )Tj EMC /Suspect <>BDC 0.286 0.29 0.275 rg /T1_3 1 Tf 0 Tc 9.5 0 0 9.5 195.68 437.05 Tm (I )Tj EMC ET BT /T1_1 1 Tf 0.0051 Tc 10.2 0 0 10.2 206.3 437.05 Tm (collected )Tj 0.0279 Tc 4.471 0 Td (after )Tj 0.0158 Tc -20.377 -1.083 Td (exhalation )Tj 0.05 Tc 11.1292 0 0 10.2 93.49 426 Tm (of )Tj 0 Tc 10.2 0 0 10.2 106.94 426 Tm (a )Tj 0.026 Tc 0.997 0 Td (washout )Tj -0.0063 Tc 3.999 0 Td (vo)Tj 0.161 0.161 0.149 rg -0.0088 Tc 1.028 0 Td (lu)Tj 0.286 0.29 0.275 rg 0.008 Tc 0.807 0 Td (me )Tj 0.05 Tc 10.5727 0 0 10.2 194.3 426 Tm (of )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0024 Tc 10.2 0 0 10.2 207.73 426 Tm (0.9 )Tj EMC ET BT /T1_3 1 Tf -0.035 Tc 9.4277 0 0 9.8 225.44 426 Tm (I. )Tj 0.223 0.223 0.212 rg /T1_1 1 Tf 0.0453 Tc 10.2 0 0 10.2 235.63 426 Tm (Prior )Tj 0.286 0.29 0.275 rg 0.0253 Tc 2.685 0 Td (to )Tj 0.0228 Tc -21.518 -1.081 Td (sample )Tj 0.0092 Tc 3.251 0 Td (collection )Tj 0.0265 Tc 4.431 0 Td (the )Tj 0.0127 Tc 1.65 0 Td (bag )Tj 0.0017 Tc 1.833 0 Td (was )Tj -0.0073 Tc 1.92 0 Td (flushed )Tj 0.0056 Tc 3.351 0 Td (with )Tj 0.0497 Tc 2.165 0 Td (room )Tj 0.0437 Tc 2.626 0 Td (air )Tj 0.0134 Tc -21.176 -1.082 Td (and )Tj 0.0083 Tc 1.975 0 Td (emptied )Tj 0 Tc 3.775 0 Td (w)Tj 0.161 0.161 0.149 rg 0.699 0 Td (i)Tj 0.286 0.29 0.275 rg 0.0253 Tc 0.288 0 Td (th )Tj 0.0377 Tc 1.259 0 Td (standard )Tj 0.0128 Tc 4.141 0 Td [(suction. )-225(Allowance )]TJ -0.0218 Tc 8.625 0 Td (was )Tj 0.0177 Tc -20.754 -1.035 Td (made )Tj -0.0051 Tc 2.579 0 Td (fo)Tj 0.161 0.161 0.149 rg 0 Tc 0.904 0 Td (r )Tj 0.286 0.29 0.275 rg 0.0029 Tc 0.752 0 Td (the )Tj 0.0144 Tc 1.639 0 Td (dilution )Tj 0.05 Tc 11.1292 0 0 10.2 141.49 393.37 Tm (of )Tj 0.0265 Tc 10.2 0 0 10.2 154.54 393.37 Tm (the )Tj 0.0051 Tc 1.639 0 Td (collected )Tj 0.0427 Tc 4.043 0 Td (samp)Tj 0.161 0.161 0.149 rg 0 Tc 2.264 0 Td (l)Tj 0.286 0.29 0.275 rg 0.233 0 Td (e )Tj 0.0141 Tc 0.81 0 Td (which )Tj -0.0096 Tc -19.813 -1.082 Td (this )Tj 0.0153 Tc 2.015 0 Td (entailed)Tj 0.404 0.408 0.396 rg 0 Tc 3.331 0 Td (. )Tj 0.286 0.29 0.275 rg 0.0317 Tc 0.859 0 Td (The )Tj 0.0246 Tc 2.269 0 Td (breathholding )Tj 0.0222 Tc 6.491 0 Td (manoeuvre )Tj 0.0125 Tc 5.216 0 Td (com\255)Tj 0.0028 Tc -20.224 -1.083 Td (prised )Tj 0.021 Tc 2.952 0 Td (exhalation )Tj 0.05 Tc 10.4772 0 0 10.2 123.33 371.28 Tm (to )Tj 0.0055 Tc 10.2 0 0 10.2 137.27 371.28 Tm (residual )Tj 0.0041 Tc 3.764 0 Td (volume)Tj 0.404 0.408 0.396 rg 0 Tc 3.045 0 Td (, )Tj 0.286 0.29 0.275 rg 0.0234 Tc 0.761 0 Td (inhalation )Tj 0.05 Tc 10.4772 0 0 10.2 262.53 371.28 Tm (to )Tj 0.0041 Tc 10.2 0 0 10.2 44.14 360.25 Tm (total )Tj 0.0088 Tc 2.252 0 Td (lung )Tj 0.0202 Tc 2.07 0 Td (capacity, )Tj 0.0285 Tc 4.152 0 Td (breathholding )Tj 0.0192 Tc 6.2 0 Td (for )Tj 0.022 Tc 1.554 0 Td (approximately )Tj 0 Tc -16.29 -1.035 Td [(8 )-101(s )]TJ -0.0094 Tc 1.617 0 Td (which )Tj -0.011 Tc 2.871 0 Td (yielded )Tj 0.05 Tc 10.2654 0 0 10.2 123.26 349.69 Tm (an )Tj -0.0105 Tc 10.2 0 0 10.2 137.17 349.69 Tm (effective )Tj 0.0246 Tc 3.871 0 Td (breathholding )Tj 0.0055 Tc 6.256 0 Td (time )Tj 0.05 Tc 11.1292 0 0 10.2 262.45 349.69 Tm (of )Tj 0.0181 Tc 10.2 0 0 10.2 43.58 338.65 Tm (approximately )Tj ET BT /Suspect <>BDC 0.223 0.223 0.212 rg /T1_1 1 Tf -0.035 Tc 9.6688 0 0 10.2 112.95 338.65 Tm (10 )Tj EMC ET BT 0.286 0.29 0.275 rg /T1_1 1 Tf -0.002 Tc 10.2 0 0 10.2 129.46 338.65 Tm (s, )Tj 0.0078 Tc 1.424 0 Td (then )Tj 0.0262 Tc 2.485 0 Td (exhalation )Tj 0.05 Tc 10.4772 0 0 10.2 221.73 338.65 Tm (to )Tj 0.0055 Tc 10.2 0 0 10.2 238.07 338.65 Tm (residual )Tj -0.0036 Tc -19.06 -1.082 Td (volume: )Tj 0.223 0.223 0.212 rg 0.0234 Tc 3.712 0 Td (inhalation )Tj 0.286 0.29 0.275 rg 0.037 Tc 4.704 0 Td (and )Tj 0.021 Tc 1.975 0 Td (exhalation )Tj -0.0024 Tc 4.81 0 Td (were )Tj 0.161 0.161 0.149 rg 0 Tc 2.353 0 Td (r)Tj 0.286 0.29 0.275 rg 0.0216 Tc 0.32 0 Td (equired )Tj 0.0253 Tc 3.585 0 Td (to )Tj 0.0078 Tc -21.456 -1.083 Td (be )Tj -0.0209 Tc 1.26 0 Td (as )Tj 0.0162 Tc 1.185 0 Td (rapid )Tj -0.0209 Tc 2.532 0 Td (as )Tj 0.004 Tc 1.188 0 Td (possible )Tj 0.037 Tc 3.659 0 Td (and )Tj 0 Tc 1.882 0 Td (o)Tj 0.161 0.161 0.149 rg 0.564 0 Td (f )Tj 0.286 0.29 0.275 rg 0.0432 Tc 0.613 0 Td (duration )Tj -0.0237 Tc 4.001 0 Td (less )Tj 0.0235 Tc 1.795 0 Td (than )Tj 0.223 0.223 0.212 rg 0 Tc 2.163 0 Td (4 )Tj 0.286 0.29 0.275 rg 0.79 0 Td (s)Tj 0.161 0.161 0.149 rg 0.464 0 Td (. )Tj 0.286 0.29 0.275 rg 0.0317 Tc -22.153 -1.081 Td (The )Tj 0.0195 Tc 2.07 0 Td (alveolar )Tj 0.0041 Tc 3.867 0 Td (volume )Tj 0.0351 Tc 3.475 0 Td (during )Tj 0.0246 Tc 3.305 0 Td (breathholding )Tj 0.223 0.223 0.212 rg -0.0218 Tc 6.351 0 Td (was )Tj 0.286 0.29 0.275 rg 0.0029 Tc 2.023 0 Td (the )Tj 0.0055 Tc -21.034 -1.035 Td (residual )Tj 0.0135 Tc 3.623 0 Td (volume )Tj 0.223 0.223 0.212 rg 0.0204 Tc 3.474 0 Td (from )Tj 0.286 0.29 0.275 rg 0.0113 Tc 2.448 0 Td (closed )Tj 0.0176 Tc 3.012 0 Td (circuit )Tj 0.0238 Tc 3.055 0 Td (spirometry )Tj 0.223 0.223 0.212 rg -0.0033 Tc 5.004 0 Td (plus )Tj 0.286 0.29 0.275 rg 0.0029 Tc -20.616 -1.082 Td (the )Tj 0.0041 Tc 1.553 0 Td (volume )Tj 0.05 Tc 11.1292 0 0 10.2 93.49 283.93 Tm (of )Tj 0.0094 Tc 10.2 0 0 10.2 105.58 283.93 Tm (test )Tj 0.0002 Tc 1.734 0 Td (gas )Tj 0.0096 Tc 1.648 0 Td (inspired. )Tj 0.05 Tc 10.2656 0 0 10.2 179.43 283.93 Tm (The )Tj -0.0105 Tc 10.2 0 0 10.2 199.09 283.93 Tm (effective )Tj 0.0195 Tc 3.719 0 Td (alveolar )Tj 0.0135 Tc -19.004 -1.082 Td (volume )Tj 0.223 0.223 0.212 rg -0.0218 Tc 3.295 0 Td (was )Tj 0.286 0.29 0.275 rg 0.0128 Tc 1.779 0 Td (calculated )Tj 0.0048 Tc 4.47 0 Td (from )Tj 0.0265 Tc 2.268 0 Td (the )Tj 0.0144 Tc 1.498 0 Td (dilution )Tj 0.161 0.161 0.149 rg -0.0079 Tc 3.531 0 Td (in )Tj 0.286 0.29 0.275 rg 0.0265 Tc 1.041 0 Td (the )Tj 0.223 0.223 0.212 rg 0.0245 Tc 1.546 0 Td (lung )Tj 0.286 0.29 0.275 rg 0.05 Tc 11.1292 0 0 10.2 262.45 272.89 Tm (of )Tj 0.0029 Tc 10.2 0 0 10.2 43.66 261.84 Tm (the )Tj 0.0021 Tc 1.507 0 Td (he)Tj 0.161 0.161 0.149 rg 0 Tc 0.98 0 Td (l)Tj 0.286 0.29 0.275 rg 0.0075 Tc 0.236 0 Td (ium )Tj 0.0148 Tc 1.939 0 Td (present )Tj 0.223 0.223 0.212 rg -0.035 Tc 9.9195 0 0 10.2 124.72 261.84 Tm (in )Tj 0.286 0.29 0.275 rg 0.0265 Tc 10.2 0 0 10.2 135.82 261.84 Tm (the )Tj 0.223 0.223 0.212 rg -0.0063 Tc 1.6 0 Td (test )Tj 0.286 0.29 0.275 rg 0.0302 Tc 1.697 0 Td (breath, )Tj 0.0189 Tc 3.236 0 Td (allowance )Tj 0.223 0.223 0.212 rg 0.0121 Tc 4.481 0 Td (being )Tj 0.286 0.29 0.275 rg 0.0177 Tc -20.097 -1.082 Td (made )Tj 0.0192 Tc 2.626 0 Td (for )Tj 0.0265 Tc 1.656 0 Td (the )Tj 0.0292 Tc 1.686 0 Td (absorption )Tj 0.05 Tc 11.1292 0 0 10.2 154.45 250.8 Tm (of )Tj 0.0437 Tc 10.2 0 0 10.2 166.94 250.8 Tm (carbon )Tj 0 Tc 3.341 0 Td (d)Tj 0.161 0.161 0.149 rg -0.0079 Tc 0.567 0 Td (io)Tj 0.286 0.29 0.275 rg -0.006 Tc 0.804 0 Td (xide )Tj 0.0459 Tc 2.124 0 Td (prior )Tj 0.0253 Tc 2.537 0 Td (to )Tj 0.0057 Tc -21.514 -1.034 Td (analysis )Tj 0.05 Tc 11.1292 0 0 10.2 83.89 240.25 Tm (of )Tj 0.223 0.223 0.212 rg 0.0013 Tc 10.2 0 0 10.2 100.31 240.25 Tm (helium )Tj 0.286 0.29 0.275 rg 0.05 Tc 10.3398 0 0 10.2 136.69 240.25 Tm (and )Tj 0.0192 Tc 10.2 0 0 10.2 160.21 240.25 Tm (for )Tj 0.0029 Tc 2.032 0 Td (the )Tj 0.0237 Tc 2.018 0 Td (instrument )Tj 0.0134 Tc 5.269 0 Td (and )Tj 0.0218 Tc -20.8 -1.082 Td (anatomical )Tj 0.0194 Tc 5.271 0 Td (deadspaces )Tj -0.035 Tc 9.0515 0 0 10.2 151.46 229.21 Tm ([4])Tj 0.404 0.408 0.396 rg 0 Tc 10.2 0 0 10.2 162.51 229.21 Tm (. )Tj 0.223 0.223 0.212 rg 0.0054 Tc 0.957 0 Td (Helium )Tj 0.286 0.29 0.275 rg 0.0017 Tc 3.769 0 Td (was )Tj 0.0065 Tc 2.297 0 Td (analysed )Tj -0.035 Tc 10.1243 0 0 10.2 43.2 218.16 Tm (us)Tj 0.161 0.161 0.149 rg 0 Tc 10.2 0 0 10.2 52.24 218.16 Tm (i)Tj 0.286 0.29 0.275 rg -0.0085 Tc 0.289 0 Td (ng )Tj 0 Tc 1.45 0 Td (a )Tj 0.0345 Tc 0.996 0 Td (katharometer )Tj 0.037 Tc 6.11 0 Td (and )Tj 0.0437 Tc 2.024 0 Td (carbon )Tj 0.0212 Tc 3.396 0 Td (monoxide )Tj -0.0022 Tc 4.662 0 Td (by )Tj 0.05 Tc 10.2654 0 0 10.2 260.54 218.16 Tm (an )Tj 0.0181 Tc 10.2 0 0 10.2 42.64 207.13 Tm (infra-red )Tj 0.013 Tc 4.092 0 Td (analyser. )Tj 0.223 0.223 0.212 rg 0.05 Tc 10.2656 0 0 10.2 126.63 207.13 Tm (The )Tj 0.286 0.29 0.275 rg 0.0216 Tc 10.2 0 0 10.2 148.3 207.13 Tm (transfer )Tj -0.0063 Tc 3.671 0 Td (test )Tj 0.0301 Tc 1.824 0 Td (spirometer )Tj 0.0017 Tc 4.954 0 Td (was )Tj 0.0198 Tc -20.809 -1.082 Td (calibrated )Tj -0.0002 Tc 4.622 0 Td (using )Tj 0.223 0.223 0.212 rg 0 Tc 2.578 0 Td (a )Tj 0.286 0.29 0.275 rg 0.0002 Tc 0.942 0 Td (gas )Tj 0.008 Tc 1.783 0 Td (syringe )Tj 0.0283 Tc 3.39 0 Td (\(Mercury )Tj 0 Tc 4.429 0 Td (E)Tj 0.161 0.161 0.149 rg 0.656 0 Td (l)Tj 0.286 0.29 0.275 rg 0.0166 Tc 0.233 0 Td (ect)Tj 0.161 0.161 0.149 rg 0 Tc 1.233 0 Td (r)Tj 0.286 0.29 0.275 rg 0.0139 Tc 0.368 0 Td (onic)Tj 0.404 0.408 0.396 rg 0 Tc 1.784 0 Td (s )Tj 0.286 0.29 0.275 rg 0.0111 Tc -21.969 -1.082 Td (Ltd\))Tj 0.404 0.408 0.396 rg 0 Tc 1.778 0 Td (, )Tj 0.286 0.29 0.275 rg 0.0029 Tc 0.578 0 Td (the )Tj 0.0132 Tc 1.545 0 Td (analysers )Tj -0.0022 Tc 4.152 0 Td (by )Tj 0.0184 Tc 1.256 0 Td (ser)Tj 0.161 0.161 0.149 rg -0.035 Tc 10.0471 0 0 10.2 150.64 185.05 Tm (ia)Tj 0.286 0.29 0.275 rg 0 Tc 10.2 0 0 10.2 158.31 185.05 Tm (l )Tj 0.0212 Tc 0.517 0 Td (dilution )Tj 0.05 Tc 11.1292 0 0 10.2 200.05 185.05 Tm (of )Tj 0.161 0.161 0.149 rg 0 Tc 10.2 0 0 10.2 212.14 185.05 Tm (t)Tj 0.286 0.29 0.275 rg 0.0201 Tc 0.274 0 Td (est )Tj 0.0237 Tc 1.414 0 Td (gas )Tj -0.0079 Tc 1.695 0 Td (in )Tj 0.0265 Tc 1.088 0 Td (the )Tj 0.0018 Tc -21.137 -1.035 Td (closed )Tj 0.0119 Tc 3.388 0 Td (circu)Tj 0.161 0.161 0.149 rg 0 Tc 2.073 0 Td (i)Tj 0.286 0.29 0.275 rg 0.288 0 Td (t )Tj 0.05 Tc 10.43 0 0 10.2 111.73 174.49 Tm (appa)Tj 0.161 0.161 0.149 rg 0 Tc 10.2 0 0 10.2 133.43 174.49 Tm (r)Tj 0.286 0.29 0.275 rg 0.0477 Tc 0.321 0 Td (atus )Tj 0.0134 Tc 2.588 0 Td (and )Tj 0.0029 Tc 2.408 0 Td (the )Tj -0.0095 Tc 2.059 0 Td (speed )Tj 0.05 Tc 11.1292 0 0 10.2 240.37 174.49 Tm (of )Tj 0.0265 Tc 10.2 0 0 10.2 257.74 174.49 Tm (the )Tj 0.0251 Tc -21.082 -1.083 Td (kymograph )Tj 0.0116 Tc 5.508 0 Td (using )Tj 0 Tc 2.908 0 Td (a )Tj 0.0191 Tc 1.173 0 Td (stop-watch. )Tj 0.05 Tc 10.2656 0 0 10.2 197.19 163.44 Tm (The )Tj 0.0251 Tc 10.2 0 0 10.2 221.74 163.44 Tm (kymograph )Tj 0.0023 Tc -17.612 -1.081 Td (speed )Tj /T1_4 1 Tf 0 Tc 9.3 0 0 9.3 68.98 152.41 Tm (\()Tj 0.161 0.161 0.149 rg 0.456 0 Td (1 )Tj ET BT /Suspect <>BDC 0.286 0.29 0.275 rg /T1_1 1 Tf 0.05 Tc 10.6187 0 0 10.2 80.54 152.41 Tm (cm\267s)Tj 0.553 0.557 0.541 rg 0 Tc 10.2 0 0 10.2 103.08 152.41 Tm (-)Tj 0.286 0.29 0.275 rg 6.2 0 0 6.2 109.71 156.25 Tm (1)Tj 0.492 -0.619 Td (\) )Tj EMC ET BT /T1_1 1 Tf 0.0017 Tc 10.2 0 0 10.2 119.51 152.41 Tm (was )Tj 0.0241 Tc 1.874 0 Td (accurate )Tj 0.0253 Tc 3.867 0 Td (to )Tj 0.0079 Tc 1.177 0 Td (within )Tj 0.05 Tc 10.5565 0 0 10.2 219.78 152.41 Tm (2% )Tj 0.037 Tc 10.2 0 0 10.2 238.46 152.41 Tm (and )Tj 0.0265 Tc 1.89 0 Td (the )Tj 0.033 Tc -21.09 -1.082 Td (other )Tj 0.223 0.223 0.212 rg 0.02 Tc 2.831 0 Td (measurements )Tj 0.286 0.29 0.275 rg 0.0253 Tc 6.635 0 Td (to )Tj -0.0015 Tc 1.554 0 Td (within )Tj 0.223 0.223 0.212 rg 0.05 Tc 10.5509 0 0 10.2 189.53 141.37 Tm (I%. )Tj 0.286 0.29 0.275 rg 10.2656 0 0 10.2 212.55 141.37 Tm (The )Tj 0.0195 Tc 10.2 0 0 10.2 236.54 141.37 Tm (alveolar )Tj 0.0013 Tc -19.004 -1.082 Td (volumes )Tj -0.0022 Tc 3.768 0 Td (by )Tj 0.0265 Tc 1.409 0 Td (the )Tj 0.0343 Tc 1.647 0 Td (mult)Tj 0.161 0.161 0.149 rg 0 Tc (i)Tj 0.286 0.29 0.275 rg 0.0298 Tc 2.262 0 Td (breath )Tj 0.037 Tc 3.048 0 Td (and )Tj -0.0016 Tc 1.925 0 Td (single )Tj 0.0392 Tc 2.791 0 Td (breath )Tj 0.0068 Tc 3.103 0 Td (meth\255)Tj -0.0019 Tc -19.961 -1.036 Td (ods )Tj -0.0024 Tc 1.703 0 Td (were )Tj -0.0027 Tc 2.25 0 Td (des)Tj 0.161 0.161 0.149 rg 0 Tc 1.367 0 Td (i)Tj 0.286 0.29 0.275 rg 0.0256 Tc 0.234 0 Td (gnated )Tj -0.0022 Tc 3.161 0 Td (respectively )Tj -0.035 Tc 8.8992 0 0 10.2 184.3 119.76 Tm (VA )Tj 0.037 Tc 10.2 0 0 10.2 200.06 119.76 Tm (and )Tj -0.035 Tc 8.8992 0 0 10.2 219.34 119.76 Tm (VA)Tj 0.404 0.408 0.396 rg 0 Tc 10.2 0 0 10.2 232.68 119.76 Tm (' )Tj 0.286 0.29 0.275 rg 0.05 Tc 10.3398 0 0 10.2 237.97 119.76 Tm (and )Tj 0.0029 Tc 10.2 0 0 10.2 257.74 119.76 Tm (the )Tj 0.0232 Tc -21.137 -1.082 Td (corresponding )Tj 0.0216 Tc 6.784 0 Td (transfer )Tj 0.0144 Tc 3.944 0 Td (factors )Tj 0.05 Tc 10.8136 0 0 10.2 188.07 108.72 Tm (TI )Tj 0.037 Tc 10.2 0 0 10.2 206.78 108.72 Tm (and )Tj 0.05 Tc 10.5892 0 0 10.2 230.31 108.72 Tm (Tl'. )Tj 0.223 0.223 0.212 rg 0.0317 Tc 10.2 0 0 10.2 253.83 108.72 Tm (The )Tj -0.0043 Tc -20.754 -1.082 Td (difference )Tj 0.286 0.29 0.275 rg -0.004 Tc 4.528 0 Td (between )Tj 0.223 0.223 0.212 rg -0.035 Tc 9.6163 0 0 10.2 127.66 97.68 Tm (VA' )Tj 0.286 0.29 0.275 rg 0.037 Tc 10.2 0 0 10.2 147.74 97.68 Tm (and )Tj 0.0265 Tc 2.078 0 Td (the )Tj 0.0135 Tc 1.788 0 Td (volume )Tj 0.05 Tc 11.1292 0 0 10.2 223.09 97.68 Tm (of )Tj 0.0251 Tc 10.2 0 0 10.2 237.1 97.68 Tm (test )Tj 0.0002 Tc 1.923 0 Td (gas )Tj 0.0063 Tc -21.034 -1.035 Td (inspired )Tj -0.0079 Tc 3.812 0 Td (in)Tj 0.757 0.761 0.745 rg 0 Tc 0.693 0 Td (.)Tj 0.286 0.29 0.275 rg 0.0253 Tc 0.16 0 Td (to )Tj 0.0265 Tc 1.365 0 Td (the )Tj 0.0402 Tc 1.781 0 Td (lung )Tj -0.035 Tc 10.069 0 0 10.2 146.28 87.12 Tm (\(V)Tj 0.161 0.161 0.149 rg 0 Tc 10.2 0 0 10.2 156.89 87.12 Tm (I)Tj 0.286 0.29 0.275 rg 0.33 0 Td (\) )Tj 0.0017 Tc 0.899 0 Td (was )Tj 0.0183 Tc 2.061 0 Td (estimated )Tj 0.0122 Tc 4.575 0 Td (residual )Tj 0.0009 Tc 5.834 64.236 Td (volume. )Tj 0.161 0.161 0.149 rg 0 Tc 3.762 0 Td (K)Tj 0.286 0.29 0.275 rg 0.05 Tc 11.347 0 0 10.2 342.61 742.33 Tm (co )Tj -0.0218 Tc 10.2 0 0 10.2 358.55 742.33 Tm (was )Tj 0.0041 Tc 1.92 0 Td (expressed )Tj 0.0261 Tc 4.425 0 Td (as )Tj 0.0216 Tc 1.325 0 Td (transfer )Tj 0.0292 Tc 3.709 0 Td (factor )Tj 0.0489 Tc 2.93 0 Td (per )Tj /T1_3 1 Tf 0 Tc 10.1 0 0 10.1 522.55 742.33 Tm (I )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0288 Tc 8 0 0 8 296.61 731.76 Tm (BTPS )Tj EMC ET BT /T1_1 1 Tf 0.0215 Tc 10.2 0 0 10.2 318.6 731.76 Tm (\(body )Tj 0.0247 Tc 2.833 0 Td (temperatu)Tj 0.161 0.161 0.149 rg 0 Tc 4.236 0 Td (r)Tj 0.286 0.29 0.275 rg 0.367 0 Td (e)Tj 0.404 0.408 0.396 rg 0.419 0 Td (, )Tj 0.286 0.29 0.275 rg 0.0377 Tc 0.567 0 Td (standard )Tj 0.223 0.223 0.212 rg 0.0163 Tc 4.063 0 Td (pressure )Tj 0.286 0.29 0.275 rg 0.0349 Tc 3.843 0 Td (saturated )Tj 0.0056 Tc -18.481 -1.081 Td (with )Tj 0.0231 Tc 2.165 0 Td (water )Tj 0.0239 Tc 2.681 0 Td (vapour\) )Tj 0.05 Tc 11.1292 0 0 10.2 382.93 720.73 Tm (of )Tj 0.0195 Tc 10.2 0 0 10.2 394.94 720.73 Tm (alveolar )Tj 0.0009 Tc 3.725 0 Td (volume. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 7.8001 0 0 7.8001 469.82 720.73 Tm (S)Tj 0.161 0.161 0.149 rg 0.559 0 Td (J )Tj EMC ET BT 0.286 0.29 0.275 rg /T1_1 1 Tf 0.032 Tc 10.2 0 0 10.2 480.48 720.73 Tm (units )Tj 0.223 0.223 0.212 rg -0.0024 Tc 2.446 0 Td (were )Tj 0.286 0.29 0.275 rg -0.0145 Tc -20.423 -1.083 Td (used. )Tj 0.223 0.223 0.212 rg 0.0317 Tc 2.485 0 Td (The )Tj 0.286 0.29 0.275 rg 0.0472 Tc 2.019 0 Td (start )Tj 0.0134 Tc 2.357 0 Td (and )Tj -0.0167 Tc 1.975 0 Td (finish )Tj 0.05 Tc 10.5727 0 0 10.2 414.62 709.68 Tm (of )Tj 0.0214 Tc 10.2 0 0 10.2 427.6 709.68 Tm (inspiration)Tj 0.404 0.408 0.396 rg 0 Tc 4.557 0 Td (, )Tj 0.223 0.223 0.212 rg 0.0293 Tc 0.665 0 Td (deadspace )Tj 0.286 0.29 0.275 rg 0.0181 Tc -18.062 -1.035 Td (washout )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 10.414 0 0 10.2 336.37 699.12 Tm (ana )Tj EMC ET BT /T1_1 1 Tf 0.0134 Tc 10.2 0 0 10.2 356.98 699.12 Tm (sample )Tj 0.0092 Tc 3.298 0 Td (collection )Tj -0.0024 Tc 4.479 0 Td (were )Tj 0.024 Tc 2.392 0 Td (located )Tj 0 Tc 3.481 0 Td (o)Tj 0.161 0.161 0.149 rg 0.574 0 Td (n )Tj 0.286 0.29 0.275 rg 0.05 Tc 0.94 0 Td (the )Tj 0.0261 Tc -21.141 -1.081 Td (spirogram )Tj -0.0022 Tc 5.097 0 Td (by )Tj -0.0243 Tc 1.776 0 Td (eye )Tj 0.037 Tc 2.119 0 Td (and )Tj 0.223 0.223 0.212 rg 0.0029 Tc 2.361 0 Td (the )Tj 0.286 0.29 0.275 rg 0.0264 Tc 2.016 0 Td (correspond)Tj 0.161 0.161 0.149 rg 0.0391 Tc 4.755 0 Td (in)Tj 0.286 0.29 0.275 rg 0 Tc 0.846 0 Td (g )Tj -0.0108 Tc 1.325 0 Td (times )Tj 0.0126 Tc -20.288 -1.082 Td (including )Tj 0.05 Tc 10.215 0 0 10.2 339.34 677.05 Tm (that )Tj 11.1292 0 0 10.2 359.41 677.05 Tm (of )Tj 0.015 Tc 10.2 0 0 10.2 371.9 677.05 Tm (actual )Tj 0.0246 Tc 2.881 0 Td (breathholding )Tj 0.033 Tc 6.152 0 Td (\(p)Tj 0.161 0.161 0.149 rg 0 Tc 0.897 0 Td (l)Tj 0.286 0.29 0.275 rg 0.05 Tc 10.2487 0 0 10.2 475.58 677.05 Tm (ateau )Tj 0.0032 Tc 10.2 0 0 10.2 503.02 677.05 Tm (time\) )Tj -0.0181 Tc -20.234 -1.036 Td (were )Tj 0.0185 Tc 2.352 0 Td (measured )Tj 0.223 0.223 0.212 rg 0.0391 Tc 4.418 0 Td (in )Tj 0.286 0.29 0.275 rg 0.0142 Tc 1.269 0 Td (duplicate )Tj 0.0253 Tc 4.29 0 Td (to )Tj ET BT /Suspect <>BDC 0.223 0.223 0.212 rg /T1_1 1 Tf -0.0271 Tc 10.2 0 0 10.2 435.2614 666.4828 Tm (0.05 )Tj EMC ET BT 0.286 0.29 0.275 rg /T1_1 1 Tf -0.035 Tc 9.9525 0 0 10.2 457.3 666.48 Tm (s. )Tj 0.223 0.223 0.212 rg 0.05 Tc 10.2656 0 0 10.2 468.39 666.48 Tm (The )Tj 0.286 0.29 0.275 rg -0.0105 Tc 10.2 0 0 10.2 489.97 666.48 Tm (effective )Tj 0.033 Tc -18.953 -1.082 Td (breathho)Tj 0.161 0.161 0.149 rg 0 Tc 3.755 0 Td (l)Tj 0.286 0.29 0.275 rg 0.0224 Tc 0.234 0 Td (ding )Tj -0.0102 Tc 2.267 0 Td (time )Tj 0.0017 Tc 2.119 0 Td (was )Tj 0.0128 Tc 1.975 0 Td (taken )Tj 0.0253 Tc 2.635 0 Td (to )Tj 0.223 0.223 0.212 rg 0.0147 Tc 1.218 0 Td (include )Tj 0.286 0.29 0.275 rg 0.05 Tc 3.394 0 Td (the )Tj 0.0308 Tc 1.651 0 Td (plateau )Tj 0.0055 Tc -19.251 -1.081 Td (time )Tj 0.0168 Tc 2.071 0 Td (together )Tj 0.0212 Tc 3.625 0 Td (with )Tj 0.05 Tc 10.2008 0 0 10.2 376.34 644.41 Tm (part )Tj 11.1292 0 0 10.2 396.37 644.41 Tm (of )Tj 0.223 0.223 0.212 rg 0.0265 Tc 10.2 0 0 10.2 407.5 644.41 Tm (the )Tj 0.286 0.29 0.275 rg 0.001 Tc 1.553 0 Td (times )Tj 0.05 Tc 11.1292 0 0 10.2 448.21 644.41 Tm (of )Tj 0.0308 Tc 10.2 0 0 10.2 459.28 644.41 Tm (inspiration )Tj 0.037 Tc 4.845 0 Td (and )Tj 0.05 Tc 11.1292 0 0 10.2 296.05 633.36 Tm (of )Tj 0.028 Tc 10.2 0 0 10.2 308.05 633.36 Tm (expiration )Tj 0.0261 Tc (as )Tj -0.0135 Tc 5.788 0 Td (follows: )Tj 0.223 0.223 0.212 rg 0.0297 Tc -6.912 -1.035 Td (Method )Tj ET BT /Suspect <>BDC 0.286 0.29 0.275 rg /T1_1 1 Tf 0 Tc 10.2 0 0 10.2 336.406 622.803 Tm (I )Tj EMC ET BT /T1_1 1 Tf 10.2 0 0 10.2 345.4738 622.803 Tm (\()Tj 0.161 0.161 0.149 rg 0.335 0 Td (J)Tj 0.286 0.29 0.275 rg 0.0236 Tc 0.42 0 Td (ones )Tj 0.05 Tc 10.3398 0 0 10.2 377.65 622.8 Tm (and )Tj 0.223 0.223 0.212 rg 0.0131 Tc 10.2 0 0 10.2 399.31 622.8 Tm (Meade\) )Tj 0.553 0.557 0.541 rg 0 Tc 3.617 0 Td (-)Tj 0.286 0.29 0.275 rg 0.0135 Tc 1.139 0 Td (two-thi)Tj 0.161 0.161 0.149 rg 0 Tc 3.013 0 Td (r)Tj 0.286 0.29 0.275 rg 0.0141 Tc 0.415 0 Td (ds )Tj 0.05 Tc 10.5727 0 0 10.2 497.66 622.8 Tm (of )Tj 0.0029 Tc 10.2 0 0 10.2 512.14 622.8 Tm (the )Tj 0.0252 Tc -21.182 -1.082 Td (inspiratory )Tj -0.0102 Tc 5.371 0 Td (time )Tj 0.037 Tc 2.486 0 Td (and )Tj 0.0029 Tc 2.314 0 Td (the )Tj 0.027 Tc 1.921 0 Td (expiratory )Tj 0.0369 Tc 5.091 0 Td (time )Tj -0.0112 Tc 2.637 0 Td (up )Tj 0.0253 Tc 1.786 0 Td (to )Tj 0.0133 Tc -21.599 -1.081 Td (halfway )Tj 0.0389 Tc 3.623 0 Td (through )Tj 0.0265 Tc 3.718 0 Td (the )Tj 0.0088 Tc 1.651 0 Td (period )Tj 0 Tc 2.953 0 Td (o)Tj 0.161 0.161 0.149 rg 0.564 0 Td (f )Tj 0.286 0.29 0.275 rg 0.0427 Tc 0.609 0 Td (samp)Tj 0.161 0.161 0.149 rg 0 Tc 2.264 0 Td (l)Tj 0.286 0.29 0.275 rg 0.233 0 Td (e )Tj 0.0115 Tc 0.754 0 Td (collection. )Tj 0.223 0.223 0.212 rg 0.0391 Tc -16.372 -1.035 Td (Method )Tj 0.286 0.29 0.275 rg 0 Tc 3.717 0 Td (2 )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0023 Tc 10.2 0 0 10.2 342.616 590.1804 Tm (\(Ogilvie )Tj EMC ET BT /T1_5 1 Tf 0.0464 Tc 10.2 0 0 10.2 379.6012 590.1804 Tm (et )Tj -0.0112 Tc 1.131 0 Td (al.\) )Tj ET BT /Suspect <>BDC 0.553 0.557 0.541 rg /T1_1 1 Tf 0 Tc 10.2 0 0 10.2 408.3652 590.1804 Tm (-)Tj EMC ET BT 0.286 0.29 0.275 rg /T1_1 1 Tf 0.0029 Tc 10.2 0 0 10.2 418.5448 590.1804 Tm (the )Tj 0.0299 Tc 1.594 0 Td (inspiratory )Tj 0.0212 Tc 5.041 0 Td (time )Tj 0.05 Tc 10.3398 0 0 10.2 508.69 590.17 Tm (and )Tj 0.0029 Tc 10.2 0 0 10.2 296.62 579.12 Tm (the )Tj 0.0055 Tc 1.6 0 Td (time )Tj 0.05 Tc 11.1292 0 0 10.2 334.45 579.12 Tm (of )Tj 0.0234 Tc 10.2 0 0 10.2 346.46 579.12 Tm (deadspace )Tj 0.0017 Tc 4.621 0 Td (was)Tj 0.161 0.161 0.149 rg 0 Tc 1.6 0 Td (h)Tj 0.286 0.29 0.275 rg 0.0311 Tc 0.509 0 Td (out. )Tj 0.0391 Tc -11.666 -1.081 Td (Method )Tj 0 Tc 3.664 0 Td (3 )Tj 0.0155 Tc 0.753 0 Td (\(American )Tj 0.223 0.223 0.212 rg 0.0197 Tc 4.756 0 Td (Thoracic )Tj 0.286 0.29 0.275 rg 0.0175 Tc 3.99 0 Td (Society's )Tj 0.0148 Tc 4.06 0 Td (Epidemiolo\255)Tj -0.0225 Tc -17.226 -1.035 Td (gical )Tj 0.032 Tc 2.531 0 Td (Standardization )Tj 0.0143 Tc 7.355 0 Td (Project\) )Tj 0.404 0.408 0.396 rg 0 Tc 3.946 0 Td (-)Tj 0.286 0.29 0.275 rg 0.0029 Tc 1.28 0 Td (the )Tj 0 Tc 1.882 0 Td (m)Tj 0.161 0.161 0.149 rg 0.0284 Tc 0.841 0 Td (idp)Tj 0.286 0.29 0.275 rg 0 Tc 1.41 0 Td (o)Tj 0.161 0.161 0.149 rg -0.0079 Tc 0.52 0 Td (in)Tj 0.286 0.29 0.275 rg 0 Tc 0.853 0 Td (t )Tj 0.05 Tc 11.1292 0 0 10.2 515.89 557.53 Tm (of )Tj 0.0214 Tc 10.2 0 0 10.2 296.08 546.48 Tm (inspiration )Tj -0.035 Tc 10.0482 0 0 10.2 349.93 546.48 Tm (by )Tj 0.0135 Tc 10.2 0 0 10.2 367.18 546.48 Tm (volume )Tj 0.05 Tc 10.4772 0 0 10.2 405.57 546.48 Tm (to )Tj 0.0029 Tc 10.2 0 0 10.2 421.9 546.48 Tm (the )Tj 0.0413 Tc 1.921 0 Td (end )Tj 0.05 Tc 11.1292 0 0 10.2 464.53 546.48 Tm (of )Tj 0.0293 Tc 10.2 0 0 10.2 480.38 546.48 Tm (deadspace )Tj 0.0134 Tc -18.062 -1.082 Td (washout. )Tj 0.0391 Tc -0.004 -1.081 Td (Method )Tj 0 Tc 3.672 0 Td (4 )Tj 0.0319 Tc 0.839 0 Td (\(Morgan )Tj 0.0328 Tc 4.049 0 Td (automatic )Tj 0.0356 Tc 4.565 0 Td (apparatus\) )Tj 0.553 0.557 0.541 rg 0 Tc 4.892 0 Td (-)Tj 0.286 0.29 0.275 rg 0.0265 Tc 0.951 0 Td (the )Tj 0.0055 Tc 1.647 0 Td (time )Tj 0.0351 Tc -20.667 -1.035 Td (during )Tj 0.0214 Tc 3.202 0 Td (inspiration )Tj 0.0171 Tc 4.901 0 Td (when )Tj 0.0265 Tc 2.634 0 Td (the )Tj 0.0142 Tc 1.698 0 Td (preset )Tj 0.223 0.223 0.212 rg 0.0293 Tc 2.812 0 Td (deadspace )Tj 0.286 0.29 0.275 rg 0.0044 Tc 4.762 0 Td (wash\255)Tj 0.05 Tc 10.9686 0 0 10.2 295.57 502.81 Tm (out )Tj 0.0135 Tc 10.2 0 0 10.2 313.42 502.81 Tm (volume )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0037 Tc 10.2 0 0 10.2 347.8756 502.81 Tm (\(0.9 )Tj EMC ET BT /T1_3 1 Tf 0.021 Tc 9.5 0 0 9.5 367.08 502.81 Tm (f\) )Tj /T1_1 1 Tf 0.0099 Tc 10.2 0 0 10.2 377.27 502.81 Tm (had )Tj -0.0137 Tc 1.884 0 Td (been )Tj 0.0303 Tc 2.156 0 Td (inhaled )Tj 0.05 Tc 10.4772 0 0 10.2 453.57 502.81 Tm (to )Tj 0.0265 Tc 10.2 0 0 10.2 466.06 502.81 Tm (the )Tj 0 Tc 1.647 0 Td (t)Tj 0.161 0.161 0.149 rg 0.324 0 Td (i)Tj 0.286 0.29 0.275 rg 0.008 Tc 0.241 0 Td (me )Tj 0.0279 Tc 1.592 0 Td (after )Tj 0.0246 Tc -20.46 -1.083 Td (breathholding )Tj 0.0014 Tc 6.116 0 Td (when )Tj 0.0029 Tc 2.493 0 Td (the )Tj 0.026 Tc 1.507 0 Td (washout )Tj 0.0229 Tc 3.717 0 Td (volume )Tj 0 Tc 3.392 0 Td (p)Tj 0.161 0.161 0.149 rg -0.0088 Tc 0.554 0 Td (lu)Tj 0.286 0.29 0.275 rg 0 Tc 0.795 0 Td (s )Tj 0.0483 Tc 0.672 0 Td (half )Tj 0.0265 Tc 1.881 0 Td (the )Tj 0.0236 Tc -21.173 -1.082 Td (preset )Tj 0.0134 Tc 2.808 0 Td (sample )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0015 Tc 9.5 0 0 9.5 357.49 480.72 Tm (\(0. )Tj EMC ET BT /T1_1 1 Tf 0 Tc 10.2 0 0 10.2 368.53 480.72 Tm (7 )Tj ET BT /Suspect <>BDC /T1_5 1 Tf -0.035 Tc 7.9695 0 0 10 377.36 480.72 Tm (I\) )Tj EMC ET BT /T1_1 1 Tf 0.0334 Tc 10.2 0 0 10.2 386.39 480.72 Tm (had )Tj 0.002 Tc 1.884 0 Td (been )Tj 0.0097 Tc 2.247 0 Td (expired. )Tj 0.0099 Tc -12.045 -1.035 Td (Two )Tj 0.223 0.223 0.212 rg 0.0072 Tc 2.172 0 Td (measurements )Tj 0.286 0.29 0.275 rg 0.05 Tc 11.1292 0 0 10.2 390.13 470.16 Tm (of )Tj 0.0149 Tc 10.2 0 0 10.2 401.74 470.16 Tm (transfer )Tj 0.0021 Tc 3.474 0 Td (facto)Tj 0.161 0.161 0.149 rg 0 Tc 2.08 0 Td (r )Tj 0.286 0.29 0.275 rg -0.0181 Tc 0.659 0 Td (were )Tj 0.0334 Tc 2.211 0 Td (made )Tj 0.05 Tc 10.7226 0 0 10.2 513.5 470.16 Tm (on )Tj 0.0087 Tc 10.2 0 0 10.2 295.57 459.12 Tm (each )Tj -0.0042 Tc 2.26 0 Td (occasion: )Tj 0.0253 Tc 4.196 0 Td (to )Tj -0.035 Tc 10.1515 0 0 10.2 374.41 459.12 Tm (be )Tj 0.0038 Tc 10.2 0 0 10.2 387.74 459.12 Tm (acceptable )Tj 0.0029 Tc 4.667 0 Td (the )Tj 0.0006 Tc 1.641 0 Td (inspi)Tj 0.161 0.161 0.149 rg 0 Tc 1.983 0 Td (r)Tj 0.286 0.29 0.275 rg 0.0179 Tc 0.32 0 Td (ed )Tj 0.0013 Tc 1.374 0 Td (volumes )Tj -0.0181 Tc -19.011 -1.081 Td (were )Tj 0.161 0.161 0.149 rg 0 Tc 2.4 0 Td (r)Tj 0.286 0.29 0.275 rg 0.0059 Tc 0.32 0 Td (equired )Tj 0.0253 Tc 3.585 0 Td (to )Tj 0.0034 Tc 1.31 0 Td (agree )Tj 0.0253 Tc 2.69 0 Td (to )Tj -0.0015 Tc 1.319 0 Td (within )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.026 Tc 10.2 0 0 10.2 445.3394 448.0938 Tm (0.2 )Tj EMC ET BT /T1_3 1 Tf 0 Tc 9.5 0 0 9.5 462.56 448.09 Tm (I)Tj 0.404 0.408 0.396 rg 0.314 0 Td (, )Tj 0.286 0.29 0.275 rg /T1_1 1 Tf 0.0029 Tc 10.2 0 0 10.2 473.26 448.09 Tm (the )Tj 0 Tc 1.733 0 Td (a)Tj 0.161 0.161 0.149 rg 0.472 0 Td (l)Tj 0.286 0.29 0.275 rg 0.0007 Tc 0.289 0 Td (veolar )Tj 0.0041 Tc -19.906 -1.082 Td (volume )Tj -0.035 Tc 9.4256 0 0 10.2 332.05 437.05 Tm (\(VA\) )Tj 0.0334 Tc 10.2 0 0 10.2 357.11 437.05 Tm (had )Tj 0.0253 Tc 2.117 0 Td (to )Tj 0.223 0.223 0.212 rg -0.035 Tc 10.1515 0 0 10.2 393.13 437.05 Tm (be )Tj 0.286 0.29 0.275 rg -0.0015 Tc 10.2 0 0 10.2 408.47 437.05 Tm (within )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0102 Tc 10.2 0 0 10.2 441.2528 437.05 Tm (10% )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 11.1292 0 0 10.2 465.97 437.05 Tm (of )Tj 0.0277 Tc 10.2 0 0 10.2 480.94 437.05 Tm (total )Tj -0.0069 Tc 2.487 0 Td (lung )Tj 0.005 Tc -20.66 -1.035 Td (capacity )Tj 0.037 Tc 3.624 0 Td (and )Tj 0.0265 Tc 1.796 0 Td (the )Tj 0.0114 Tc 1.459 0 Td (measurements )Tj 0.05 Tc 11.0133 0 0 10.2 427.57 426.49 Tm (ofTI' )Tj -0.0022 Tc 10.2 0 0 10.2 454.09 426.49 Tm (by )Tj 0.0239 Tc 1.221 0 Td (metho)Tj 0.161 0.161 0.149 rg 0 Tc 2.627 0 Td (d )Tj 0.223 0.223 0.212 rg 0.759 0 Td (4 )Tj 0.05 Tc 10.2918 0 0 10.2 508.31 426.49 Tm (had )Tj 0.286 0.29 0.275 rg -0.0217 Tc 10.2 0 0 10.2 296.14 415.44 Tm (to )Tj 0.0034 Tc 1.027 0 Td (agree )Tj 0.0253 Tc 2.455 0 Td (to )Tj -0.0015 Tc 1.13 0 Td (within )Tj 0.05 Tc 10.3203 0 0 10.2 372.34 415.44 Tm (5% )Tj -0.035 Tc 9.4074 0 0 10.2 389.53 415.44 Tm ([5]. )Tj 0.223 0.223 0.212 rg 0.0317 Tc 10.2 0 0 10.2 404.55 415.44 Tm (The )Tj 0.0166 Tc 1.929 0 Td (latter )Tj 0.286 0.29 0.275 rg -0.0011 Tc 2.36 0 Td (values )Tj -0.0024 Tc 2.825 0 Td (were )Tj 0.0056 Tc 2.156 0 Td (calcu\255)Tj 0.0012 Tc -19.952 -1.081 Td (lated )Tj 0.05 Tc 10.7518 0 0 10.2 319.09 404.41 Tm (at )Tj 0 Tc 10.2 0 0 10.2 330.7 404.41 Tm (t)Tj 0.161 0.161 0.149 rg 0.33 0 Td (h)Tj 0.286 0.29 0.275 rg 0.508 0 Td (e )Tj -0.0102 Tc 0.809 0 Td (time )Tj 0.223 0.223 0.212 rg -0.0002 Tc 2.12 0 Td (using )Tj 0.286 0.29 0.275 rg 0 Tc 2.437 0 Td (a )Tj 0.223 0.223 0.212 rg 0.0188 Tc 0.805 0 Td (Hewlett-Packard )Tj 0.286 0.29 0.275 rg -0.0152 Tc 7.24 0 Td (9825 )Tj -0.0038 Tc 2.308 0 Td (calcu\255)Tj 0.161 0.161 0.149 rg 0 Tc -19.999 -1.082 Td (l)Tj 0.286 0.29 0.275 rg 0.0226 Tc 0.234 0 Td (ator. )Tj 0.223 0.223 0.212 rg 0.0102 Tc 2.311 0 Td (Pairs )Tj 0.286 0.29 0.275 rg 0.05 Tc 11.1292 0 0 10.2 346.45 393.37 Tm (of )Tj 0.0072 Tc 10.2 0 0 10.2 359.02 393.37 Tm (measurements )Tj -0.035 Tc 10.1476 0 0 10.2 421.91 393.37 Tm (wh)Tj 0.161 0.161 0.149 rg 0 Tc 10.2 0 0 10.2 434.32 393.37 Tm (i)Tj 0.286 0.29 0.275 rg 0.0182 Tc 0.233 0 Td (ch )Tj ET BT /Suspect <>BDC /C0_0 1 Tf 0 Tc 7.92 0 0 7.68 450.24 393.37 Tm <006D007E0020>Tj EMC ET BT /T1_1 1 Tf 0.0052 Tc 10.2 0 0 10.2 469.9 393.37 Tm (these )Tj 0.0092 Tc 2.392 0 Td (criteria )Tj -0.0181 Tc -19.474 -1.082 Td (were )Tj -0.0144 Tc 2.448 0 Td (used )Tj -0.0044 Tc 2.389 0 Td (for )Tj 0.0029 Tc 1.75 0 Td (the )Tj 0.0176 Tc 1.733 0 Td (comparison )Tj 0.223 0.223 0.212 rg 0.05 Tc 11.1292 0 0 10.2 435.25 382.33 Tm (of )Tj 0.286 0.29 0.275 rg 0.0124 Tc 10.2 0 0 10.2 449.27 382.33 Tm (results )Tj 0.0197 Tc 3.191 0 Td (calcu)Tj 0.161 0.161 0.149 rg 0 Tc 2.166 0 Td (l)Tj 0.286 0.29 0.275 rg 0.0141 Tc 0.234 0 Td (ated )Tj -0.0237 Tc -20.602 -1.036 Td (using )Tj 0.0029 Tc 2.633 0 Td (the )Tj -0.0223 Tc 1.779 0 Td (effective )Tj 0.0167 Tc 3.871 0 Td (breathholding )Tj -0.0108 Tc 6.303 0 Td (times )Tj 0.223 0.223 0.212 rg -0.0022 Tc 2.685 0 Td (by )Tj 0.286 0.29 0.275 rg 0.0029 Tc 1.55 0 Td (the )Tj 0.0187 Tc 1.779 0 Td (four )Tj 0.0056 Tc -20.65 -1.082 Td (methods. )Tj 0 Tc 4.275 0 Td (T)Tj 0.161 0.161 0.149 rg 0.714 0 Td (h)Tj 0.286 0.29 0.275 rg 0.003 Tc 0.509 0 Td (ose )Tj -0.0097 Tc 1.987 0 Td (before )Tj 0.0178 Tc 3.091 0 Td (salbutamol )Tj -0.0024 Tc 5.189 0 Td (were )Tj 0.0076 Tc 2.485 0 Td (calculated )Tj 0.0174 Tc -18.25 -1.081 Td (without )Tj 0.0071 Tc 3.426 0 Td (allowance )Tj -0.0044 Tc 4.423 0 Td (for )Tj 0.0343 Tc 1.46 0 Td (carbon )Tj 0.0078 Tc 3.208 0 Td (monoxide )Tj 0.0334 Tc 4.379 0 Td (back )Tj -0.0011 Tc 2.303 0 Td (tension; )Tj -0.0032 Tc -19.199 -1.082 Td (results )Tj 0.0279 Tc 2.909 0 Td (after )Tj 0.0178 Tc 2.255 0 Td (salbutamol )Tj -0.0181 Tc 4.907 0 Td (were )Tj 0.223 0.223 0.212 rg 0.0157 Tc 2.25 0 Td (obtained )Tj 0.286 0.29 0.275 rg 0.0279 Tc 3.906 0 Td (after )Tj 0.0227 Tc 2.267 0 Td (making )Tj 0 Tc 3.38 0 Td (a )Tj 0.0125 Tc -21.929 -1.082 Td (correction )Tj 0.05 Tc 10.5727 0 0 10.2 341.66 327.61 Tm (of )Tj ET BT /Suspect <>BDC 0.223 0.223 0.212 rg /T1_1 1 Tf -0.035 Tc 9.6688 0 0 10.2 354.87 327.61 Tm (10 )Tj EMC ET BT /T1_1 1 Tf 0.0101 Tc 10.2 0 0 10.2 367.7 327.61 Tm (ppm )Tj 0.286 0.29 0.275 rg -0.0094 Tc 2.209 0 Td (which )Tj 0.0017 Tc 2.776 0 Td (was )Tj 0.0029 Tc 1.928 0 Td (the )Tj 0.002 Tc 1.639 0 Td (average )Tj 0.223 0.223 0.212 rg -0.0011 Tc 3.531 0 Td (increase )Tj 0.286 0.29 0.275 rg 0.024 Tc -19.202 -1.083 Td (attributable )Tj 0.0253 Tc 5.09 0 Td (to )Tj 0.0029 Tc 1.129 0 Td (the )Tj 0.0071 Tc 1.453 0 Td (initia)Tj 0.161 0.161 0.149 rg 0 Tc 2.117 0 Td (l )Tj ET BT /Suspect <>BDC 0.286 0.29 0.275 rg /T1_1 1 Tf 0.0054 Tc 10.2 0 0 10.2 399.728 316.5634 Tm (deterrllinations )Tj EMC ET BT /T1_1 1 Tf -0.0079 Tc 10.2 0 0 10.2 465.0284 316.5634 Tm (in )Tj 0.0055 Tc 1.045 0 Td (preliminary )Tj -0.0027 Tc -17.707 -1.081 Td (experiments. )Tj 0.0317 Tc 5.508 0 Td (The )Tj 0.223 0.223 0.212 rg 0.0034 Tc 1.987 0 Td (procedures, )Tj 0.286 0.29 0.275 rg 0.018 Tc 5.023 0 Td (equations )Tj 0.037 Tc 4.33 0 Td (and )Tj -0.0054 Tc 1.938 0 Td (reference )Tj -0.0105 Tc -18.73 -1.035 Td (values )Tj 0.0313 Tc 2.816 0 Td (are )Tj -0.0009 Tc 1.6 0 Td (described )Tj -0.035 Tc 9.9195 0 0 10.2 383.44 294.97 Tm (in )Tj 0.223 0.223 0.212 rg 0.0008 Tc 10.2 0 0 10.2 394.94 294.97 Tm (detail )Tj 0.286 0.29 0.275 rg -0.0084 Tc 2.54 0 Td (elsewhere )Tj /T1_3 1 Tf -0.035 Tc 9.1314 0 0 10 464.63 294.97 Tm ([4]. )Tj /T1_1 1 Tf 0.0121 Tc 10.2 0 0 10.2 305.09 283.93 Tm (Subjects )Tj 0.0334 Tc 3.782 0 Td (had )Tj 0.05 Tc 10.4827 0 0 10.2 362.87 283.93 Tm (not )Tj 0.0233 Tc 10.2 0 0 10.2 380.5 283.93 Tm (smoked )Tj 0.0192 Tc 3.579 0 Td (for )Tj 0.05 Tc 10.7518 0 0 10.2 432.85 283.93 Tm (at )Tj 0.0054 Tc 10.2 0 0 10.2 444.39 283.93 Tm (least )Tj 0 Tc 2.215 0 Td (2 )Tj 0.161 0.161 0.149 rg 0.805 0 Td (h)Tj 0.286 0.29 0.275 rg 0.55 0 Td (, )Tj 0.223 0.223 0.212 rg 0.05 Tc 10.4078 0 0 10.2 486.71 283.93 Tm (nor )Tj 0.0013 Tc 10.2 0 0 10.2 504.96 283.93 Tm (used )Tj 0.286 0.29 0.275 rg 0.0137 Tc -20.52 -1.082 Td (their )Tj 0.0282 Tc 2.294 0 Td (salbutamol )Tj 0.223 0.223 0.212 rg 0.0145 Tc 5.088 0 Td (inhalers )Tj 0.286 0.29 0.275 rg 0.0192 Tc 3.668 0 Td (for )Tj 0.05 Tc 10.7518 0 0 10.2 425.17 272.89 Tm (at )Tj 0.0054 Tc 10.2 0 0 10.2 437.67 272.89 Tm (least )Tj 0 Tc 2.264 0 Td [(4 )-194(h )]TJ 0.0092 Tc 1.887 0 Td (before )Tj 0.0029 Tc 3.056 0 Td (the )Tj -0.0079 Tc -21.129 -1.083 Td (tests )Tj -0.035 Tc 10.1476 0 0 10.2 318.71 261.84 Tm (wh)Tj 0.161 0.161 0.149 rg 0 Tc 10.2 0 0 10.2 331.6 261.84 Tm (i)Tj 0.286 0.29 0.275 rg 0.0182 Tc 0.233 0 Td (ch )Tj -0.0024 Tc 1.515 0 Td (were )Tj -0.035 Tc 9.9195 0 0 10.2 374.32 261.84 Tm (in )Tj 0.0265 Tc 10.2 0 0 10.2 387.34 261.84 Tm (the )Tj 0.0426 Tc 1.78 0 Td (order )Tj 0.223 0.223 0.212 rg 0.0242 Tc 2.729 0 Td (dynamic )Tj 0.286 0.29 0.275 rg 0.0246 Tc 4.043 0 Td (spirometry, )Tj 0.0322 Tc -17.596 -1.034 Td (anthropometry, )Tj 0.223 0.223 0.212 rg 0.0283 Tc 7.114 0 Td (transfer )Tj 0.286 0.29 0.275 rg 0.0198 Tc 3.709 0 Td (factor )Tj 0.05 Tc 10.3398 0 0 10.2 435.73 251.29 Tm (and )Tj 0.0262 Tc 10.2 0 0 10.2 456.34 251.29 Tm (static )Tj 0.0245 Tc 2.687 0 Td (lung )Tj 0.0231 Tc 2.313 0 Td (vol)Tj 0.404 0.408 0.396 rg 0 Tc 1.308 0 Td (\255)Tj 0.161 0.161 0.149 rg -0.035 Tc 10.0532 0 0 10.2 295.68 240.25 Tm (um)Tj 0.286 0.29 0.275 rg 9.7768 0 0 10.2 308.54 240.25 Tm (e. )Tj 0.0121 Tc 10.2 0 0 10.2 319.49 240.25 Tm (Subjects )Tj 0.0235 Tc 3.875 0 Td (then )Tj 0.0147 Tc 2.206 0 Td (inhaled )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0302 Tc 9.5 0 0 9.5 416.58 240.25 Tm (200y )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 11.1292 0 0 10.2 440.05 240.25 Tm (of )Tj 0.037 Tc 10.2 0 0 10.2 452.5 240.25 Tm (salbutamo)Tj 0.161 0.161 0.149 rg 0 Tc 4.428 0 Td (l )Tj 0.286 0.29 0.275 rg 0.0384 Tc 0.611 0 Td (afte)Tj 0.161 0.161 0.149 rg 0 Tc 1.609 0 Td (r )Tj 0.286 0.29 0.275 rg -0.0027 Tc -22.071 -1.082 Td (whic)Tj 0.161 0.161 0.149 rg 0 Tc 1.929 0 Td (h )Tj 0.286 0.29 0.275 rg 0.0265 Tc 0.893 0 Td (the )Tj 0.0071 Tc 1.604 0 Td (physiological )Tj 0.223 0.223 0.212 rg 0.0157 Tc 5.878 0 Td (measurements )Tj 0.286 0.29 0.275 rg -0.0024 Tc 6.26 0 Td (were )Tj 0.0144 Tc 2.306 0 Td (repeated )Tj 0.161 0.161 0.149 rg 0 Tc -18.877 -1.083 Td (i)Tj 0.286 0.29 0.275 rg 0.289 0 Td (n )Tj 0.0029 Tc 0.846 0 Td (the )Tj 0.0146 Tc 1.541 0 Td (same )Tj 0.0426 Tc 2.404 0 Td (order)Tj 0.404 0.408 0.396 rg 0 Tc 2.342 0 Td (. )Tj 0.286 0.29 0.275 rg 0.05 Tc 10.2656 0 0 10.2 375.75 218.16 Tm (The )Tj 0.0098 Tc 10.2 0 0 10.2 395.9 218.16 Tm (average )Tj 0.0055 Tc 3.49 0 Td (time )Tj 0.0116 Tc 2.121 0 Td (between )Tj 0.0029 Tc 3.762 0 Td (the )Tj -0.007 Tc 1.544 0 Td (first )Tj 0.0287 Tc -20.846 -1.081 Td (determination )Tj 0.05 Tc 11.1292 0 0 10.2 358.45 207.13 Tm (of )Tj 0.223 0.223 0.212 rg 10.95 0 0 10.2 369.99 207.13 Tm (Tl )Tj 0.286 0.29 0.275 rg 0.0092 Tc 10.2 0 0 10.2 384.97 207.13 Tm (before )Tj 0.037 Tc 2.907 0 Td (and )Tj 0.0279 Tc 1.882 0 Td (after )Tj 0.037 Tc 2.255 0 Td (salbutamo)Tj 0.161 0.161 0.149 rg 0 Tc 4.428 0 Td (l )Tj 0.286 0.29 0.275 rg 0.0017 Tc 0.573 0 Td (was )Tj -0.0246 Tc -20.86 -1.082 Td (54 )Tj -0.0038 Tc 1.329 0 Td (min. )Tj 0.223 0.223 0.212 rg 0.0286 Tc 2.256 0 Td (Duplicate )Tj 0.286 0.29 0.275 rg 0.0255 Tc 4.466 0 Td (determinations )Tj -0.0024 Tc 6.644 0 Td (were )Tj 0.0259 Tc 2.293 0 Td (separated )Tj -0.0022 Tc 4.438 0 Td (by )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0 Tc 10.8 0 0 10.8 295.08 185.52 Tm (7)Tj 0.757 0.761 0.745 rg 0.399 0 Td (-)Tj 0.286 0.29 0.275 rg -0.035 Tc 9.1317 0 0 10.8 306.88 185.52 Tm (10 )Tj EMC ET BT 0.223 0.223 0.212 rg /T1_1 1 Tf -0.0038 Tc 10.2 0 0 10.2 320.62 185.52 Tm (min. )Tj 0.286 0.29 0.275 rg 0.05 Tc 10.2656 0 0 10.2 344.07 185.52 Tm (The )Tj 0.0157 Tc 10.2 0 0 10.2 366.22 185.52 Tm (measurements )Tj -0.0024 Tc 6.401 0 Td (were )Tj 0.223 0.223 0.212 rg 0.0211 Tc 2.4 0 Td (repeated )Tj 0.286 0.29 0.275 rg 0.05 Tc 11.3843 0 0 10.2 497.16 185.52 Tm (at )Tj 0.0265 Tc 10.2 0 0 10.2 510.7 185.52 Tm (the )Tj 0.0303 Tc -21.188 -1.081 Td (same )Tj 0.0055 Tc 2.506 0 Td (time )Tj 0.05 Tc 11.1292 0 0 10.2 342.13 174.49 Tm (of )Tj 0.0359 Tc 10.2 0 0 10.2 354.14 174.49 Tm (day )Tj 0.0046 Tc 1.937 0 Td (two )Tj -0.0114 Tc 1.883 0 Td (weeks )Tj 0.0126 Tc 2.816 0 Td (later. )Tj 0.223 0.223 0.212 rg 0.05 Tc 10.2656 0 0 10.2 446.79 174.49 Tm (The )Tj 0.286 0.29 0.275 rg 0.0354 Tc 10.2 0 0 10.2 467.43 174.49 Tm (latter )Tj 0.223 0.223 0.212 rg 0.0018 Tc 2.596 0 Td (results, )Tj 0.286 0.29 0.275 rg -0.0094 Tc -19.482 -1.083 Td (which )Tj 0.0248 Tc 2.862 0 Td (did )Tj 0.05 Tc 10.4827 0 0 10.2 342.23 163.44 Tm (not )Tj 0.0004 Tc 10.2 0 0 10.2 360.86 163.44 Tm (differ )Tj 0.0021 Tc 2.631 0 Td (sign)Tj 0.161 0.161 0.149 rg 0 Tc 1.7 0 Td (i)Tj 0.286 0.29 0.275 rg -0.0082 Tc 0.279 0 Td (ficantly )Tj 0.223 0.223 0.212 rg 0.0048 Tc 3.482 0 Td (from )Tj 0.286 0.29 0.275 rg 0.0263 Tc 2.456 0 Td (those )Tj 0.05 Tc 10.2564 0 0 10.2 495.26 163.44 Tm (on )Tj 0 Tc 10.2 0 0 10.2 510.7 163.44 Tm (t)Tj 0.161 0.161 0.149 rg 0.33 0 Td (h)Tj 0.286 0.29 0.275 rg 0.508 0 Td (e )Tj -0.035 Tc 8.0782 0 0 10.2 295.11 152.41 Tm (fi)Tj 0.161 0.161 0.149 rg 0 Tc 10.2 0 0 10.2 300.47 152.41 Tm (r)Tj 0.286 0.29 0.275 rg 0.0181 Tc 0.364 0 Td (st )Tj 0.0168 Tc 0.992 0 Td (occasion, )Tj -0.0024 Tc 4.244 0 Td (were )Tj 0.0013 Tc 2.26 0 Td (used )Tj -0.0217 Tc 2.257 0 Td (to )Tj 0.0252 Tc 1.074 0 Td (estimate )Tj 0.0265 Tc 3.821 0 Td (the )Tj 0.0082 Tc 1.65 0 Td (between-day )Tj 0.0111 Tc -17.226 -1.082 Td (variability. )Tj -0.0233 Tc 4.8 0 Td (All )Tj 0.223 0.223 0.212 rg -0.035 Tc 10.1707 0 0 10.2 359.89 141.37 Tm (flow )Tj 0.0112 Tc 10.2 0 0 10.2 381.11 141.37 Tm (rates )Tj 0.286 0.29 0.275 rg 0.05 Tc 10.3398 0 0 10.2 403.57 141.37 Tm (and )Tj 0.0013 Tc 10.2 0 0 10.2 422.86 141.37 Tm (volumes )Tj -0.0311 Tc 3.672 0 Td (we)Tj 0.161 0.161 0.149 rg 0 Tc 1.176 0 Td (r)Tj 0.286 0.29 0.275 rg 0.32 0 Td (e )Tj 0.0041 Tc 0.706 0 Td (expressed )Tj 0.05 Tc 10.7518 0 0 10.2 294.61 130.8 Tm (at )Tj 0.0267 Tc 10.2 0 0 10.2 309.13 130.8 Tm (body )Tj 0.0291 Tc 2.632 0 Td (tem)Tj 0.161 0.161 0.149 rg 0 Tc 1.604 0 Td (p)Tj 0.286 0.29 0.275 rg 0.0354 Tc 0.505 0 Td (erature )Tj 0.0349 Tc 3.574 0 Td (saturated )Tj 0.161 0.161 0.149 rg 0 Tc 4.436 0 Td (w)Tj 0.286 0.29 0.275 rg 0.0223 Tc 0.746 0 Td (ith )Tj 0.0231 Tc 1.701 0 Td (water )Tj 0.0483 Tc 2.823 0 Td (vapour )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0225 Tc 8 0 0 8 294.63 119.76 Tm (\(BTPS\). )Tj EMC ET BT /T1_1 1 Tf 0.0239 Tc 10.2 0 0 10.2 328.75 119.76 Tm (Hence )Tj 0.223 0.223 0.212 rg 0.0087 Tc 3.196 0 Td (TI/VA )Tj 0.0455 Tc 3.244 0 Td (\(Kco\) )Tj 0.286 0.29 0.275 rg 0.0334 Tc 3.117 0 Td (had )Tj 0.0265 Tc 2.164 0 Td (the )Tj 0.0085 Tc 1.884 0 Td (units )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 10.2 0 0 10.2 493.8982 119.76 Tm (mmol\267 )Tj EMC /Suspect <>BDC 0.0017 Tc -19.529 -1.035 Td (min)Tj 0.639 0.639 0.628 rg 0 Tc 1.684 0 Td (-)Tj 0.286 0.29 0.275 rg 6.5001 0 0 6.5001 318.5 112.08 Tm (1)Tj 0.161 0.161 0.149 rg 0.05 Tc 10.914 0 0 10.2 323.29 109.2 Tm (\267kP)Tj 0.286 0.29 0.275 rg 0 Tc 10.2 0 0 10.2 338.78 109.2 Tm (a)Tj 0.553 0.557 0.541 rg 0.61 0 Td (-)Tj 0.404 0.408 0.396 rg 6.5001 0 0 6.5001 351.14 112.08 Tm (1)Tj 0.286 0.29 0.275 rg 0.831 -0.443 Td (\225 )Tj EMC ET BT /T1_5 1 Tf 9.8 0 0 9.8 363.73 109.2 Tm (l )Tj ET BT /Suspect <>BDC 0.223 0.223 0.212 rg /T1_1 1 Tf -0.0088 Tc 8 0 0 8 370.53 109.2 Tm (BTPS)Tj 0.553 0.557 0.541 rg 0 Tc 2.513 0 Td (-)Tj 0.286 0.29 0.275 rg 6.5001 0 0 6.5001 396.26 112.57 Tm (1)Tj 0.161 0.161 0.149 rg 0.678 -0.518 Td (. )Tj EMC ET BT 0.223 0.223 0.212 rg /T1_1 1 Tf 0.0239 Tc 10.2 0 0 10.2 406.99 109.2 Tm (Mathematical )Tj 0.0057 Tc 6.207 0 Td (analysis )Tj 0.286 0.29 0.275 rg -0.0218 Tc 3.679 0 Td (was )Tj 0.0221 Tc -20.891 -1.129 Td (performed )Tj 0.223 0.223 0.212 rg -0.0002 Tc 4.892 0 Td (using )Tj 0.286 0.29 0.275 rg 0.05 Tc 10.2654 0 0 10.2 371.42 97.68 Tm (an )Tj 0.223 0.223 0.212 rg 0.0045 Tc 10.2 0 0 10.2 387.29 97.68 Tm (IBM )Tj ET BT /Suspect <>BDC 0.286 0.29 0.275 rg /T1_1 1 Tf -0.0257 Tc 10.2 0 0 10.2 412.1984 97.68 Tm (370 )Tj EMC ET BT /T1_1 1 Tf 0.0304 Tc 10.2 0 0 10.2 431.4968 97.68 Tm (mainframe )Tj 0.0353 Tc 5.027 0 Td (computer )Tj 0.037 Tc -18.447 -1.035 Td (and )Tj 0.0029 Tc 1.937 0 Td (the )Tj 0.0193 Tc 1.536 0 Td (Statistical )Tj 0.0204 Tc 4.531 0 Td (Package )Tj 0.0192 Tc 3.759 0 Td (for )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0186 Tc 10.2 0 0 10.2 430.3544 87.123 Tm (Socia)Tj 0.161 0.161 0.149 rg 0 Tc 2.316 0 Td (l )Tj EMC /Suspect <>BDC 0.286 0.29 0.275 rg -0.0035 Tc 0.555 0 Td (Sciences )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 11.1292 0 0 10.2 498.13 87.12 Tm (of )Tj 0.0029 Tc 10.2 0 0 10.2 510.7 87.12 Tm (the )Tj ET endstream endobj 3 0 obj <>stream Hd͊zy8 >sRhF^#y QG#Oç==o/ϧ;c_mӷKv|~_oo~y>}~W=|z>{O݇q~?>Ï?o+~ߒ~;%zΏx߽w;>lp?(O?{wٸ^ PZUuTGu^5P5FjFDMԤU PjVjUmFmک]uPuNNE]E5|| _#_k55|| _#_k55|| _#_k55|| _#_k5Z||-_+_kZ||-_+_kZ||-_+_kZ||-_+_ku:||_'_uu:||_'_uu:||_'_uu:||_'_uz||=_/_z||=_/_z||=_/_z||=_/_ || ߀o77 || ߀o77 || ߀o77 || ߀o77 KG#(~? ?G#(~? ?G#(~? ?G#(~? ?z $߄o77MM&|| $߄o77MM&|| $߄o77MM&|| $߄o77MM&||3,ߌo77f||3,ߌo77f||3,ߌo77f||3,ߌo77f|| "߂oȷ[--|| "߂oȷ[--|| "߂oȷ[--|| 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Tc 9.9 0 0 9.9 119.98 732.24 Tm (the )Tj 0.0115 Tc 1.737 0 Td (coefficient )Tj 0.05 Tc 11.1292 0 0 9.9 184.69 732.24 Tm (of )Tj 0.0357 Tc 9.9 0 0 9.9 198.22 732.24 Tm (variation )Tj 0.05 Tc 11.1292 0 0 9.9 241.33 732.24 Tm (of )Tj 0 Tc 9.9 0 0 9.9 254.78 732.24 Tm (a )Tj 0.31 0.31 0.298 rg 0.966 0 Td (s)Tj 0.165 0.165 0.157 rg 0.0018 Tc 0.394 0 Td (ingle )Tj 0.239 0.243 0.231 rg 0.0333 Tc -20.899 -1.067 Td (observation; )Tj 0.31 0.31 0.298 rg 0.0208 Tc 5.778 0 Td (this )Tj 0.239 0.243 0.231 rg 0.001 Tc 1.989 0 Td (was )Tj 0.0215 Tc 2.084 0 Td (the )Tj 0.05 Tc 9.963 0 0 9.9 176.02 721.68 Tm (standard )Tj 0.0335 Tc 9.9 0 0 9.9 217.83 721.68 Tm (deviation )Tj 0.05 Tc 10.5727 0 0 9.9 261.98 721.68 Tm (of )Tj 0.0215 Tc 9.9 0 0 9.9 275.5 721.68 Tm (the )Tj 0.0352 Tc -21.632 -1.114 Td (observation )Tj 0.0192 Tc 5.771 0 Td (divided )Tj 0.0278 Tc 3.937 0 Td (by )Tj 0.0215 Tc 1.839 0 Td (the )Tj 0.0261 Tc 2.028 0 Td (overall )Tj 0.0401 Tc 3.741 0 Td (mean )Tj 0.013 Tc 3.055 0 Td (value. )Tj 0.0267 Tc -20.366 -1.115 Td (Percentage )Tj 0.0246 Tc 5.182 0 Td (changes )Tj 0.165 0.165 0.157 rg 0.0149 Tc 3.926 0 Td (following )Tj 0.31 0.31 0.298 rg 0.0384 Tc 4.603 0 Td (salbutamol )Tj 0.239 0.243 0.231 rg 0.0355 Tc 5.337 0 Td (and )Tj 0.165 0.165 0.157 rg 0.0162 Tc 2.145 0 Td (per\255)Tj 0.239 0.243 0.231 rg 0.0285 Tc -21.248 -1.067 Td (centage )Tj 0.0081 Tc 3.977 0 Td (differences )Tj 0.0126 Tc 5.392 0 Td (between )Tj 0.0179 Tc 4.265 0 Td (results )Tj -0.0207 Tc 3.59 0 Td (by )Tj 0.0215 Tc 1.839 0 Td (the )Tj 0.05 Tc 9.939 0 0 9.9 269.65 689.05 Tm (four )Tj 0.0344 Tc 9.9 0 0 9.9 61.42 678 Tm (methods )Tj 0.0009 Tc 3.88 0 Td (were )Tj 0.0191 Tc 2.172 0 Td (expressed )Tj 0.05 Tc 10.0636 0 0 9.9 164.56 678 Tm (in )Tj 0.0457 Tc 9.9 0 0 9.9 175.66 678 Tm (the )Tj 0.0086 Tc 1.591 0 Td (form )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0113 Tc 9.9 0 0 9.9 215.1808 678 Tm (100 )Tj EMC /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 6.437 0 0 12.4 232.27 678 Tm (l!J.x)Tj 0.388 0.388 0.384 rg 0 Tc 12.4 0 0 12.4 243.2 678 Tm (f)Tj 0.239 0.243 0.231 rg 0.285 0 Td (x )Tj EMC ET BT 0.31 0.31 0.298 rg /T1_0 1 Tf 9.9 0 0 9.9 254.16 678 Tm ([)Tj 0.165 0.165 0.157 rg -0.035 Tc 9.2649 0 0 9.9 257.92 678 Tm (17] )Tj 0.239 0.243 0.231 rg 0.05 Tc 10.0265 0 0 9.9 272.06 678 Tm (and )Tj 0.0427 Tc 9.9 0 0 9.9 60.86 667.44 Tm (compared )Tj 0.0162 Tc 4.616 0 Td (using )Tj 0.0262 Tc 2.523 0 Td (paired )Tj 0.0231 Tc 3.002 0 Td (t-tests )Tj 0.0386 Tc 2.853 0 Td (on )Tj 0.026 Tc 1.367 0 Td (results )Tj 0.0267 Tc 3.045 0 Td (calculated )Tj 0.0496 Tc 4.663 0 Td (to )Tj 0.0362 Tc -22.07 -1.114 Td (four )Tj 0.0173 Tc 2.179 0 Td (significant )Tj -0.0054 Tc 4.706 0 Td (figures. )Tj 0.05 Tc 10.4358 0 0 9.9 163.15 656.41 Tm (For )Tj 0.0408 Tc 9.9 0 0 9.9 181.94 656.41 Tm (purposes )Tj 0.05 Tc 11.1292 0 0 9.9 223.09 656.41 Tm (of )Tj 0.0374 Tc 9.9 0 0 9.9 235.22 656.41 Tm (presentation )Tj 0.165 0.165 0.157 rg 0.0179 Tc -17.603 -1.116 Td (results )Tj 0.239 0.243 0.231 rg 0.0171 Tc 3.2 0 Td (were )Tj 0.0439 Tc 2.473 0 Td (rounded )Tj 0.05 Tc 10.0193 0 0 9.9 156.86 645.36 Tm (off )Tj 0.0496 Tc 9.9 0 0 9.9 173.26 645.36 Tm (to )Tj 0.0274 Tc 1.358 0 Td (two )Tj 0.31 0.31 0.298 rg 0.05 Tc 11.1292 0 0 9.9 206.77 645.36 Tm (or )Tj 0.239 0.243 0.231 rg 0.0349 Tc 9.9 0 0 9.9 220.78 645.36 Tm (three )Tj -0.0051 Tc 2.609 0 Td (figures )Tj 0.0033 Tc 3.298 0 Td (as )Tj 0.017 Tc -22.113 -1.067 Td (seemed )Tj 0.0364 Tc 3.495 0 Td (appropriate. )Tj 0.165 0.165 0.157 rg 0.0112 Tc 6.502 -2.764 Td (Results )Tj 0.239 0.243 0.231 rg 0.0322 Tc -8.961 -1.696 Td (Nineteen )Tj 0.0392 Tc 4.212 0 Td (men )Tj 0.05 Tc 10.0265 0 0 9.9 134.78 590.65 Tm (and )Tj 0.0402 Tc 9.9 0 0 9.9 154.94 590.65 Tm (one )Tj 0.0414 Tc 1.948 0 Td (women )Tj 0.0171 Tc 3.539 0 Td (were )Tj 0.0076 Tc 2.415 0 Td (assessed. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0053 Tc 9.9 0 0 9.9 274.3736 590.65 Tm (Six )Tj EMC ET BT /T1_0 1 Tf 0.0171 Tc 9.9 0 0 9.9 60.4643 580.0867 Tm (were )Tj 0.31 0.31 0.298 rg 0.0309 Tc 2.508 0 Td (smokers )Tj 0.239 0.243 0.231 rg 0.05 Tc 10.3398 0 0 9.9 125.17 580.09 Tm (and )Tj 0.0457 Tc 9.9 0 0 9.9 146.38 580.09 Tm (the )Tj 0.0394 Tc 1.843 0 Td (remainder )Tj 0.31 0.31 0.298 rg 0.0167 Tc 4.887 0 Td (exsmokers. )Tj 0.239 0.243 0.231 rg 0.032 Tc 5.294 0 Td (After )Tj 0.0384 Tc -20.715 -1.115 Td (salbutamol )Tj -0.0081 Tc 5.192 0 Td (all )Tj 0.028 Tc 1.455 0 Td (completed )Tj 0.0457 Tc 4.905 0 Td (the )Tj 0.0174 Tc 1.745 0 Td (tests )Tj 0.31 0.31 0.298 rg 0.0266 Tc 2.267 0 Td (satisfactorily )Tj 0.239 0.243 0.231 rg 0.05 Tc 10.18 0 0 9.9 273.61 569.05 Tm (but )Tj 0.0346 Tc 9.9 0 0 9.9 60.49 558.48 Tm (before )Tj 0.31 0.31 0.298 rg 0.0384 Tc 2.942 0 Td (salbutamol )Tj 0.239 0.243 0.231 rg 0.0274 Tc 5.055 0 Td (two )Tj 0.0287 Tc 1.83 0 Td (subjects )Tj 0.0318 Tc 3.64 0 Td (could )Tj 0.05 Tc 10.1333 0 0 9.9 220.31 558.48 Tm (not )Tj 0.0307 Tc 9.9 0 0 9.9 237.62 558.48 Tm (perform )Tj 0.31 0.31 0.298 rg 0.0457 Tc 3.729 0 Td (the )Tj 0.239 0.243 0.231 rg 0.0352 Tc -21.624 -1.115 Td (measurement )Tj 0.05 Tc 11.1292 0 0 9.9 119.41 547.44 Tm (of )Tj 0.0285 Tc 9.9 0 0 9.9 131.5 547.44 Tm (transfer )Tj 0.0346 Tc 3.627 0 Td (factor )Tj 0.0236 Tc 2.822 0 Td (within )Tj 0.0457 Tc 3.005 0 Td (the )Tj 0.0444 Tc 1.543 0 Td (constraints )Tj 0.31 0.31 0.298 rg 0.0054 Tc -18.234 -1.114 Td (specified. )Tj 0.165 0.165 0.157 rg 0.0391 Tc 4.47 0 Td (Detail)Tj 0.31 0.31 0.298 rg 0 Tc 2.658 0 Td (s )Tj 0.239 0.243 0.231 rg 0.05 Tc 11.1292 0 0 9.9 139.57 536.41 Tm (of )Tj 0.0215 Tc 9.9 0 0 9.9 154.06 536.41 Tm (the )Tj 0.165 0.165 0.157 rg 0.0332 Tc 1.843 0 Td (remaining )Tj 0.239 0.243 0.231 rg -0.035 Tc 9.1317 0 0 9.9 221.44 536.41 Tm (18 )Tj 0.0218 Tc 9.9 0 0 9.9 235.54 536.41 Tm (subjects )Tj 0.05 Tc 9.9087 0 0 9.9 274.46 536.41 Tm (are )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0063 Tc 9.9 0 0 9.9 59.92 525.85 Tm (given )Tj EMC ET BT /T1_0 1 Tf 0.0149 Tc 9.9 0 0 9.9 85.363 525.85 Tm (in )Tj 0.0368 Tc (table )Tj 0.165 0.165 0.157 rg /T1_2 1 Tf 0.05 Tc 10.489 0 0 9.4 118.75 525.85 Tm (I. )Tj 0.239 0.243 0.231 rg /T1_0 1 Tf 9.9723 0 0 9.9 127.59 525.85 Tm (The )Tj 10.2291 0 0 9.9 146.84 525.85 Tm (FEV )Tj 0.31 0.31 0.298 rg 0 Tc 6.2 0 0 6.2 167.79 523.44 Tm (1 )Tj 0.239 0.243 0.231 rg 0.0252 Tc 9.9 0 0 9.9 173.75 525.85 Tm (was )Tj 0.05 Tc 10.7226 0 0 9.9 192.38 525.85 Tm (on )Tj 0.0258 Tc 9.9 0 0 9.9 205.82 525.85 Tm (average )Tj 0.0461 Tc 3.535 0 Td (53% )Tj 0.05 Tc 11.1292 0 0 9.9 262.93 525.85 Tm (of )Tj 0.0457 Tc 9.9 0 0 9.9 274.54 525.85 Tm (the )Tj 0.0206 Tc -21.672 -1.116 Td (reference )Tj 0.0182 Tc 4.702 0 Td (value )Tj 0.0364 Tc 3.044 0 Td (\(range )Tj 0.05 Tc 10.0876 0 0 9.9 171.78 514.8 Tm (27-106%\) )Tj 10.3398 0 0 9.9 224.05 514.8 Tm (and )Tj 0.0216 Tc 9.9 0 0 9.9 248.08 514.8 Tm (increased )Tj 0.0249 Tc -19 -1.115 Td (materially )Tj 0.0425 Tc 4.598 0 Td (after )Tj 0.0438 Tc 2.275 0 Td (salbutamol )Tj 0.031 Tc 5.044 0 Td (\(average )Tj 0.0199 Tc 3.931 0 Td (increase )Tj 0.0095 Tc 3.853 0 Td (16.5%\). )Tj 0.165 0.165 0.157 rg 0.05 Tc 10.2656 0 0 9.9 59.43 492.72 Tm (The )Tj 0.239 0.243 0.231 rg 0.0263 Tc 9.9 0 0 9.9 79.67 492.72 Tm (residual )Tj 0.0223 Tc 3.732 0 Td (volume )Tj 0.0252 Tc 3.443 0 Td (was )Tj 0.0149 Tc 1.981 0 Td (in )Tj 0.165 0.165 0.157 rg 0.05 Tc 10.1622 0 0 9.9 181.9 492.72 Tm (mo)Tj 0.31 0.31 0.298 rg 10.4235 0 0 9.9 195.21 492.72 Tm (st )Tj 0.239 0.243 0.231 rg 0.0232 Tc 9.9 0 0 9.9 206.32 492.72 Tm (instances )Tj 0.0216 Tc 4.218 0 Td (increased )Tj 0.0497 Tc -19.057 -1.067 Td (compared )Tj 0.0236 Tc 4.712 0 Td (with )Tj 0.0457 Tc 2.278 0 Td (the )Tj 0.0206 Tc 1.698 0 Td (reference )Tj 0.0182 Tc 4.314 0 Td (value )Tj 0.05 Tc 10.0265 0 0 9.9 213.98 482.16 Tm (and )Tj 0.0252 Tc 9.9 0 0 9.9 234.23 482.16 Tm (was )Tj 0.0306 Tc 1.988 0 Td (reduced )Tj 0.0278 Tc -19.586 -1.115 Td (by )Tj 0.0386 Tc 1.245 0 Td (salbutamol. )Tj 0.0471 Tc 5.291 0 Td (Total )Tj 0.0431 Tc 2.57 0 Td (lung )Tj 0.0403 Tc 2.083 0 Td (capacity )Tj 0.001 Tc 3.888 0 Td (was )Tj 0.0333 Tc 1.794 0 Td (within )Tj 0.0456 Tc 3.006 0 Td (normal )Tj 0.0137 Tc -19.886 -1.114 Td (limits )Tj 0.0353 Tc 2.711 0 Td (\(mean )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0219 Tc 9.9 0 0 9.9 117.7367 460.0929 Tm (107% )Tj EMC ET BT /T1_0 1 Tf 0.0236 Tc 9.9 0 0 9.9 145.9319 460.0929 Tm (predicted, )Tj 0.0271 Tc 4.652 0 Td (range )Tj -0.035 Tc 9.6981 0 0 9.9 219.26 460.09 Tm (78)Tj 0.561 0.561 0.549 rg 0 Tc 9.9 0 0 9.9 229.32 460.09 Tm (-)Tj 0.239 0.243 0.231 rg 0.0266 Tc 0.657 0 Td (137%, )Tj 0.0247 Tc 3.135 0 Td (table )Tj 0.165 0.165 0.157 rg 0.0088 Tc -20.902 -1.115 Td (II\). )Tj 0.239 0.243 0.231 rg 0.05 Tc 9.9723 0 0 9.9 75.75 449.05 Tm (The )Tj 0.0424 Tc 9.9 0 0 9.9 95.02 449.05 Tm (transfer )Tj 0.0346 Tc 3.579 0 Td (factor )Tj 0.0356 Tc 2.811 0 Td (\(TI\) )Tj 0.165 0.165 0.157 rg 0.05 Tc 10.3398 0 0 9.9 177.97 449.05 Tm (and )Tj 0 Tc 9.9 0 0 9.9 197.24 449.05 Tm (K)Tj 0.31 0.31 0.298 rg 0.05 Tc 11.347 0 0 9.9 204.85 449.05 Tm (co )Tj 0.239 0.243 0.231 rg 0.0009 Tc 9.9 0 0 9.9 218.87 449.05 Tm (were )Tj 0.0386 Tc 2.27 0 Td (on )Tj 0.0258 Tc 1.358 0 Td (average )Tj 0.0465 Tc -19.692 -1.067 Td (82% )Tj 0.05 Tc 9.9273 0 0 9.9 81.98 438.49 Tm (ofpredicted )Tj 0.31 0.31 0.298 rg 0.0364 Tc 9.9 0 0 9.9 134.28 438.49 Tm (\(range )Tj 0.239 0.243 0.231 rg 0.0497 Tc 2.964 0 Td (26-148%\); )Tj 0.0457 Tc 4.998 0 Td (the )Tj 0.024 Tc 1.503 0 Td (values )Tj 0.0448 Tc 2.902 0 Td (did )Tj 0.05 Tc 10.1333 0 0 9.9 273.11 438.49 Tm (not )Tj 0.0138 Tc 9.9 0 0 9.9 59.43 427.44 Tm (differ )Tj 0.0143 Tc 2.904 0 Td (significantly )Tj 0.0207 Tc 5.882 0 Td (between )Tj 0.0306 Tc 4.111 0 Td (duplicates )Tj 0.05 Tc 10.5727 0 0 9.9 236.54 427.44 Tm (or )Tj 0.0126 Tc 9.9 0 0 9.9 252.97 427.44 Tm (between )Tj 0.0309 Tc -19.551 -1.114 Td (attendances. )Tj 0.165 0.165 0.157 rg 0.05 Tc 9.9723 0 0 9.9 115.59 416.41 Tm (The )Tj 0.239 0.243 0.231 rg 0.0355 Tc 9.9 0 0 9.9 136.3 416.41 Tm (transfer )Tj 0.0443 Tc 3.627 0 Td (factor )Tj 0.0321 Tc 2.91 0 Td (calculated )Tj 0.0162 Tc 4.762 0 Td (using )Tj 0.0457 Tc 2.616 0 Td (the )Tj 0.0241 Tc -21.685 -1.115 Td (single-breath )Tj 0.027 Tc 6.307 0 Td (alveolar )Tj 0.0223 Tc 4.226 0 Td (volume )Tj 0.05 Tc 10.2816 0 0 9.9 202.44 405.37 Tm (\(Tl'\) )Tj 0.0252 Tc 9.9 0 0 9.9 229.91 405.37 Tm (was )Tj 0.165 0.165 0.157 rg 0.0225 Tc 2.424 0 Td (reduced )Tj 0.239 0.243 0.231 rg 0.0497 Tc -19.694 -1.115 Td (compared )Tj 0.0236 Tc 4.664 0 Td (with )Tj 0.165 0.165 0.157 rg 0.05 Tc 10.8137 0 0 9.9 126.63 394.33 Tm (TI )Tj 0.239 0.243 0.231 rg -0.0207 Tc 9.9 0 0 9.9 141.13 394.33 Tm (by )Tj 0.05 Tc 10.2564 0 0 9.9 154.46 394.33 Tm (on )Tj 0.0258 Tc 9.9 0 0 9.9 168.86 394.33 Tm (average )Tj 0.165 0.165 0.157 rg 0.0083 Tc 3.758 0 Td (12%. )Tj 0.239 0.243 0.231 rg 0.0328 Tc -13.836 -1.068 Td (Before )Tj 0.0438 Tc 3.481 0 Td (salbutamol )Tj 0.0215 Tc 5.491 0 Td (the )Tj 0.0333 Tc 1.94 0 Td (within )Tj 0.05 Tc 10.3398 0 0 9.9 210.61 383.76 Tm (and )Tj 0.0239 Tc 9.9 0 0 9.9 233.77 383.76 Tm (between-day )Tj 0.165 0.165 0.157 rg 0 Tc -17.603 -1.115 Td (v)Tj 0.31 0.31 0.298 rg 0.428 0 Td (a)Tj 0.165 0.165 0.157 rg 0.0206 Tc 0.542 0 Td (ri)Tj 0.31 0.31 0.298 rg 0.0211 Tc 0.67 0 Td (ability )Tj 0.239 0.243 0.231 rg 0.05 Tc 10.8007 0 0 9.9 104.54 372.72 Tm (ofKco, )Tj 10.8137 0 0 9.9 138.63 372.72 Tm (TI )Tj 0.31 0.31 0.298 rg 10.0265 0 0 9.9 151.58 372.72 Tm (and )Tj 0.239 0.243 0.231 rg 10.8471 0 0 9.9 169.35 372.72 Tm (Tl' )Tj 0.0171 Tc 9.9 0 0 9.9 184.79 372.72 Tm (were )Tj 0.05 Tc 10.2564 0 0 9.9 206.3 372.72 Tm (on )Tj 0.0338 Tc 9.9 0 0 9.9 219.26 372.72 Tm (average )Tj 0.05 Tc 9.9645 0 0 9.9 254.26 372.72 Tm (5% )Tj 10.3398 0 0 9.9 270.61 372.72 Tm (and )Tj 0.0443 Tc 9.9 0 0 9.9 312.34 743.29 Tm (5.9% )Tj 0.0094 Tc 2.68 0 Td (respectively. )Tj 0.05 Tc 9.9723 0 0 9.9 394.95 743.29 Tm (The )Tj 0.0314 Tc 9.9 0 0 9.9 415.66 743.29 Tm (variability )Tj 0.0149 Tc 4.891 0 Td (in )Tj 0.165 0.165 0.157 rg 0.05 Tc 10.8137 0 0 9.9 476.07 743.29 Tm (TI )Tj 0.239 0.243 0.231 rg 0.0252 Tc 9.9 0 0 9.9 491.51 743.29 Tm (was )Tj 0.31 0.31 0.298 rg 0.0175 Tc 2.023 0 Td (signi)Tj 0.165 0.165 0.157 rg -0.035 Tc 9.684 0 0 9.9 531.73 743.29 Tm (fi\255)Tj 0.239 0.243 0.231 rg 0.0396 Tc 9.9 0 0 9.9 311.9 732.73 Tm (cantly )Tj 0.0327 Tc 3.006 0 Td (correlated )Tj 0.0398 Tc 4.712 0 Td (with )Tj 0.05 Tc 10.215 0 0 9.9 411.34 732.73 Tm (that )Tj 0.0149 Tc 9.9 0 0 9.9 432.4 732.73 Tm (in )Tj 0.0339 Tc 1.21 0 Td (alveolar )Tj 0.032 Tc 3.887 0 Td (volume )Tj 0.05 Tc 9.7229 0 0 9.7 518.29 732.73 Tm (\(V )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0255 Tc 8.5 0 0 8.5 528.59 732.73 Tm (1\\\). )Tj EMC ET BT /T1_0 1 Tf 0.0441 Tc 9.9 0 0 9.9 311.98 721.68 Tm (After )Tj 0.31 0.31 0.298 rg 0.0175 Tc 2.752 0 Td (sa)Tj 0.165 0.165 0.157 rg 0.0421 Tc 0.927 0 Td (lbutamol )Tj 0.0457 Tc 4.37 0 Td (the )Tj 0.239 0.243 0.231 rg 0.0314 Tc 1.745 0 Td (variability )Tj 0.05 Tc 11.6856 0 0 9.9 457.33 721.68 Tm (of )Tj 0.165 0.165 0.157 rg 11.2642 0 0 9.9 471.26 721.68 Tm (Tl' )Tj 0.239 0.243 0.231 rg 0.0252 Tc 9.9 0 0 9.9 489.59 721.68 Tm (was )Tj 0.0495 Tc 2.078 0 Td (greater )Tj 0.05 Tc 10.0233 0 0 9.9 311.98 711.12 Tm (than )Tj 9.9231 0 0 9.9 335.02 711.12 Tm (that )Tj 11.1292 0 0 9.9 354.61 711.12 Tm (of )Tj 10.8915 0 0 9.9 366.67 711.12 Tm (Kco )Tj 9.9989 0 0 9.9 389.16 711.12 Tm (\(p )Tj 0.31 0.31 0.298 rg /T1_2 1 Tf 0 Tc 10.1 0 0 10.1 399.68 711.12 Tm (< )Tj ET BT /Suspect <>BDC 0.239 0.243 0.231 rg /T1_0 1 Tf 0.0032 Tc 9.9 0 0 9.9 407.9 711.12 Tm (0.05\). )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 0.05 Tc 11.0829 0 0 9.9 434.77 711.12 Tm (Of )Tj EMC ET BT 0.239 0.243 0.231 rg /T1_0 1 Tf 0.0457 Tc 9.9 0 0 9.9 449.26 711.12 Tm (the )Tj 0.05 Tc 9.939 0 0 9.9 465.49 711.12 Tm (four )Tj 0.0425 Tc 9.9 0 0 9.9 487.66 711.12 Tm (methods )Tj 0.0457 Tc 4.024 0 Td (the )Tj 0.0265 Tc -21.77 -1.114 Td (variability )Tj 0.0278 Tc 4.755 0 Td (by )Tj 0.05 Tc 9.9182 0 0 9.9 372.46 700.09 Tm (method )Tj 0.0274 Tc 9.9 0 0 9.9 408.94 700.09 Tm (two )Tj 0.0252 Tc 1.892 0 Td (was )Tj 0.31 0.31 0.298 rg 0.05 Tc 10.2564 0 0 9.9 447.26 700.09 Tm (on )Tj 0.239 0.243 0.231 rg 0.0338 Tc 9.9 0 0 9.9 461.66 700.09 Tm (average )Tj 0.05 Tc 10.0419 0 0 9.9 498.1 700.09 Tm (5.2% )Tj 10.3398 0 0 9.9 524.05 700.09 Tm (and )Tj -0.0207 Tc 9.9 0 0 9.9 312.49 689.05 Tm (by )Tj 0.0415 Tc 1.355 0 Td (method )Tj 0.165 0.165 0.157 rg 0.0362 Tc 3.627 0 Td (four )Tj 0.239 0.243 0.231 rg 0.044 Tc 2.185 0 Td (it )Tj 0.001 Tc 0.977 0 Td (was )Tj 0.165 0.165 0.157 rg 0.038 Tc 1.936 0 Td (4.6% )Tj 0.239 0.243 0.231 rg 0.0398 Tc 2.621 0 Td (with )Tj 0.0457 Tc 2.278 0 Td (the )Tj 0.05 Tc 10.3198 0 0 9.9 477.02 689.05 Tm (other )Tj 0.0425 Tc 9.9 0 0 9.9 503.98 689.05 Tm (methods )Tj 0.31 0.31 0.298 rg 0 Tc -19.4 -1.068 Td (i)Tj 0.165 0.165 0.157 rg 0.0333 Tc 0.298 0 Td (ntermediate)Tj 0.31 0.31 0.298 rg 0 Tc 5.119 0 Td (. )Tj 0.239 0.243 0.231 rg 0.05 Tc 9.9506 0 0 9.9 373.85 678.48 Tm (In )Tj 0.0327 Tc 9.9 0 0 9.9 389.14 678.48 Tm (some )Tj 0.0311 Tc 2.818 0 Td (individual )Tj 0.0448 Tc 4.992 0 Td (comparisons )Tj 0.0457 Tc 6.117 0 Td (the )Tj 0.0081 Tc -21.728 -1.115 Td (differences )Tj 0.032 Tc 4.857 0 Td (reached )Tj 0.0232 Tc 3.672 0 Td (statistical )Tj 0.0177 Tc 4.364 0 Td (significance )Tj 0.165 0.165 0.157 rg 0.0437 Tc 5.335 0 Td (\(table )Tj 0.05 Tc 10.1818 0 0 9.9 520.25 667.44 Tm (III)Tj 0.31 0.31 0.298 rg 0.0177 Tc 9.9 0 0 9.9 531.78 667.44 Tm (\). )Tj 0.165 0.165 0.157 rg 0.05 Tc 9.9723 0 0 9.9 321.51 656.41 Tm (The )Tj 0.239 0.243 0.231 rg 0.0386 Tc 9.9 0 0 9.9 341.18 656.41 Tm (absolute )Tj 0.165 0.165 0.157 rg 0.0485 Tc 3.936 0 Td (re)Tj 0.31 0.31 0.298 rg 0 Tc 0.811 0 Td (s)Tj 0.165 0.165 0.157 rg 0.0364 Tc 0.402 0 Td (ults )Tj 0.239 0.243 0.231 rg 0.0171 Tc 1.841 0 Td (were )Tj 0.0287 Tc 2.327 0 Td (highest )Tj -0.0207 Tc 3.396 0 Td (by )Tj 0.05 Tc 9.9182 0 0 9.9 479.98 656.41 Tm (method )Tj 0 Tc 9.9 0 0 9.9 516.36 656.41 Tm (3 )Tj 0.05 Tc 10.6532 0 0 9.9 524.05 656.41 Tm (and )Tj 0.165 0.165 0.157 rg 0.0245 Tc 9.9 0 0 9.9 311.92 645.85 Tm (lowest )Tj 0.239 0.243 0.231 rg 0.0278 Tc 2.967 0 Td (by )Tj 0.05 Tc 9.9182 0 0 9.9 353.74 645.85 Tm (method )Tj 0 Tc 9.9 0 0 9.9 388.74 645.85 Tm (2 )Tj 0.0236 Tc 0.732 0 Td (with )Tj 0.0215 Tc 2.181 0 Td (the )Tj 0.05 Tc 10.1049 0 0 9.9 432.86 645.85 Tm (other )Tj 0.0425 Tc 9.9 0 0 9.9 457.9 645.85 Tm (methods )Tj 0.0342 Tc 3.976 0 Td (tending )Tj 0.05 Tc 10.4772 0 0 9.9 531.33 645.85 Tm (to )Tj 0.0363 Tc 9.9 0 0 9.9 312.01 634.8 Tm (be )Tj 0.0293 Tc 1.591 0 Td (intermediate. )Tj 0.0424 Tc 6.293 0 Td (Salbutamol )Tj 0.0448 Tc 5.585 0 Td (did )Tj 0.165 0.165 0.157 rg 0.05 Tc 10.1333 0 0 9.9 466.07 634.8 Tm (not )Tj 0.239 0.243 0.231 rg 0.0322 Tc 9.9 0 0 9.9 487.1 634.8 Tm (alter )Tj 0.05 Tc 10.8137 0 0 9.9 512.55 634.8 Tm (TI )Tj 0.0278 Tc 9.9 0 0 9.9 529.93 634.8 Tm (by )Tj 0.05 Tc 9.9182 0 0 9.9 311.5 623.76 Tm (method )Tj 0 Tc 9.9 0 0 9.9 350.06 623.76 Tm (1 )Tj 0.05 Tc 10.18 0 0 9.9 359.53 623.76 Tm (but )Tj 0.165 0.165 0.157 rg 10.3221 0 0 9.9 378.15 623.76 Tm (TI )Tj 0.239 0.243 0.231 rg 0.0278 Tc 9.9 0 0 9.9 394.09 623.76 Tm (by )Tj 0.165 0.165 0.157 rg 0.0425 Tc 1.548 0 Td (methods )Tj 0.239 0.243 0.231 rg -0.0038 Tc 4.166 0 Td (2, )Tj 0 Tc 1.303 0 Td (3 )Tj 0.05 Tc 10.3398 0 0 9.9 473.17 623.76 Tm (and )Tj 0.165 0.165 0.157 rg 0 Tc 9.9 0 0 9.9 494.36 623.76 Tm (4 )Tj 0.239 0.243 0.231 rg 0.0009 Tc 1.07 0 Td (were )Tj 0.0161 Tc 2.512 0 Td (all )Tj 0.0143 Tc -22.065 -1.114 Td (significantly )Tj 0.0252 Tc 5.443 0 Td (reduced. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0276 Tc 9.9 0 0 9.9 403.5968 612.7314 Tm (This )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.9799 0 0 9.9 424.79 612.73 Tm (had )Tj 0.31 0.31 0.298 rg 0.0457 Tc 9.9 0 0 9.9 443.02 612.73 Tm (the )Tj 0 Tc 1.542 0 Td (e)Tj 0.165 0.165 0.157 rg -0.0136 Tc 0.485 0 Td (ffect )Tj 0.239 0.243 0.231 rg 0.05 Tc 10.1201 0 0 9.9 483.34 612.73 Tm (that, )Tj 0.0371 Tc 9.9 0 0 9.9 505.43 612.73 Tm (whereas )Tj 0.165 0.165 0.157 rg 0.0249 Tc -19.537 -1.067 Td (before )Tj 0.239 0.243 0.231 rg 0.0438 Tc 3.282 0 Td (salbutamol )Tj 0.0425 Tc 5.394 0 Td (methods )Tj 0 Tc 4.38 0 Td (1 )Tj 0.05 Tc 10.3398 0 0 9.9 451.57 602.17 Tm (and )Tj 0 Tc 9.9 0 0 9.9 474.18 602.17 Tm (2 )Tj 0.0227 Tc 1.113 0 Td (gave )Tj 0.035 Tc 2.564 0 Td (similar )Tj 0.165 0.165 0.157 rg 0.026 Tc -20.108 -1.116 Td (results)Tj 0.31 0.31 0.298 rg 0 Tc 2.798 0 Td (, )Tj 0.239 0.243 0.231 rg 0.0425 Tc 0.538 0 Td (after )Tj 0.0384 Tc 2.275 0 Td (salbutamol )Tj 0.0215 Tc 5.103 0 Td (the )Tj 0.026 Tc 1.601 0 Td (results )Tj 0.0278 Tc 3.057 0 Td (by )Tj 0.05 Tc 10.0662 0 0 9.9 476.62 591.12 Tm (method )Tj 0 Tc 9.9 0 0 9.9 512.58 591.12 Tm (2 )Tj 0.0171 Tc 0.781 0 Td (were )Tj 0.31 0.31 0.298 rg 0.0143 Tc -21.104 -1.067 Td (significantly )Tj 0.239 0.243 0.231 rg 0.0169 Tc 5.485 0 Td (lower )Tj 0.0278 Tc 2.676 0 Td (by )Tj 0.05 Tc 10.2564 0 0 9.9 405.02 580.56 Tm (on )Tj 0.0338 Tc 9.9 0 0 9.9 418.46 580.56 Tm (average )Tj 0.0442 Tc 3.634 0 Td (3.9%. )Tj 0.165 0.165 0.157 rg 0.05 Tc 11.1638 0 0 9.9 481.87 580.56 Tm (Kco )Tj 0.239 0.243 0.231 rg 0.0367 Tc 9.9 0 0 9.9 504.49 580.56 Tm (behaved )Tj 0.02 Tc -19.506 -1.114 Td (similarly )Tj 0.0167 Tc 4.328 0 Td (whilst )Tj 0.05 Tc 10.3436 0 0 9.9 384.87 569.53 Tm (TI' )Tj 0.0252 Tc 9.9 0 0 9.9 404.15 569.53 Tm (was )Tj 0.0166 Tc 2.231 0 Td (unaffected )Tj 0.0278 Tc 5.043 0 Td (by )Tj 0.0438 Tc 1.633 0 Td (salbutamol )Tj 0.034 Tc -18.277 -1.116 Td (\(table )Tj 0.0445 Tc 2.769 0 Td (III\). )Tj 0.05 Tc 10.2656 0 0 9.9 321.03 547.44 Tm (The )Tj 0.032 Tc 9.9 0 0 9.9 341.74 547.44 Tm (volume )Tj 0.0204 Tc 3.533 0 Td (inspired )Tj 0.0252 Tc 3.837 0 Td (was )Tj 0.0276 Tc 1.981 0 Td (increased )Tj 0.0278 Tc 4.421 0 Td (by )Tj 0.0438 Tc 1.439 0 Td (salbutamol )Tj 0.034 Tc -18.277 -1.066 Td (\(table )Tj 0.0084 Tc 2.914 0 Td (IV\). )Tj 0.165 0.165 0.157 rg 0.0274 Tc 2.232 0 Td (Residual )Tj 0.239 0.243 0.231 rg 0.0223 Tc 4.221 0 Td (volume )Tj 0.05 Tc 10.3398 0 0 9.9 439.57 536.89 Tm (and )Tj 0.0394 Tc 9.9 0 0 9.9 460.21 536.89 Tm (estimated )Tj 0.0263 Tc 4.665 0 Td (residual )Tj 0.0223 Tc -19.686 -1.115 Td (volume )Tj 0.0171 Tc 3.395 0 Td (were )Tj 0.05 Tc 10.0136 0 0 9.9 367.69 525.85 Tm (both )Tj 0.0321 Tc 9.9 0 0 9.9 389.75 525.85 Tm (reduced, )Tj 0.0457 Tc 3.926 0 Td (the )Tj 0.0488 Tc 1.545 0 Td (latter )Tj 0.05 Tc 10.4772 0 0 9.9 469.41 525.85 Tm (to )Tj 0 Tc 9.9 0 0 9.9 480.38 525.85 Tm (a )Tj 0.165 0.165 0.157 rg 0.0234 Tc 0.729 0 Td (lesser )Tj 0.31 0.31 0.298 rg 0.0396 Tc 2.615 0 Td (extent )Tj 0.239 0.243 0.231 rg 0.05 Tc 10.0233 0 0 9.9 311.5 514.8 Tm (than )Tj 0.0457 Tc 9.9 0 0 9.9 334.06 514.8 Tm (the )Tj 0.0342 Tc 1.688 0 Td (former )Tj 0.0353 Tc 3.247 0 Td (\(mean )Tj 0.0327 Tc 2.96 0 Td (changes )Tj 0.165 0.165 0.157 rg 0.0154 Tc 3.791 0 Td (respectively )Tj -0.01 Tc 5.445 0 Td (12.6 )Tj 0.239 0.243 0.231 rg 0.05 Tc 10.3398 0 0 9.9 523.57 514.8 Tm (and )Tj -0.035 Tc 9.5577 0 0 9.9 311.41 504.25 Tm (9.1 )Tj /T1_2 1 Tf 0.05 Tc 9.5205 0 0 9.4 324.32 504.25 Tm (%\). )Tj 0.165 0.165 0.157 rg /T1_0 1 Tf 9.9723 0 0 9.9 345.03 504.25 Tm (The )Tj 0.239 0.243 0.231 rg 0.0197 Tc 9.9 0 0 9.9 367.11 504.25 Tm (different )Tj 0.0234 Tc 4.178 0 Td (responses )Tj 0.05 Tc 10.017 0 0 9.9 454.57 504.25 Tm (bad )Tj 0.0457 Tc 9.9 0 0 9.9 476.14 504.25 Tm (the )Tj -0.0044 Tc 1.833 0 Td (effect )Tj 0.05 Tc 10.215 0 0 9.9 522.7 504.25 Tm (that )Tj 0.0209 Tc 9.9 0 0 9.9 311.51 493.21 Tm (whereas )Tj -0.035 Tc 9.3061 0 0 9.8 349.42 493.21 Tm (VA' )Tj 0.165 0.165 0.157 rg 0.0294 Tc 9.9 0 0 9.9 368.08 493.21 Tm (increa)Tj 0.31 0.31 0.298 rg -0.031 Tc 2.612 0 Td (se)Tj 0.165 0.165 0.157 rg 0 Tc 0.781 0 Td (d )Tj 0.239 0.243 0.231 rg 0.0425 Tc 0.969 0 Td (after )Tj 0.0435 Tc 2.372 0 Td (salbutamol, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.8992 0 0 9.8 488.62 493.21 Tm (VA )Tj EMC ET BT /T1_0 1 Tf 0.0448 Tc 9.9 0 0 9.9 504.87 493.21 Tm (did )Tj 0.165 0.165 0.157 rg 0.0416 Tc 1.802 0 Td (not. )Tj 0.239 0.243 0.231 rg 0.05 Tc 9.9723 0 0 9.9 310.95 482.16 Tm (The )Tj 0.31 0.31 0.298 rg 0 Tc 9.9 0 0 9.9 330.7 482.16 Tm (t)Tj 0.165 0.165 0.157 rg 0.0111 Tc 0.333 0 Td (ime )Tj 0.239 0.243 0.231 rg 0.05 Tc 11.1292 0 0 9.9 351.73 482.16 Tm (of )Tj 0.31 0.31 0.298 rg 0.0311 Tc 9.9 0 0 9.9 363.28 482.16 Tm (ins)Tj 0.165 0.165 0.157 rg 0.0423 Tc 1.271 0 Td (piration )Tj 0.239 0.243 0.231 rg 0.0252 Tc 3.73 0 Td (was )Tj 0.0166 Tc 1.94 0 Td (unaffected )Tj 0.165 0.165 0.157 rg 0.0278 Tc 4.753 0 Td (by )Tj 0.239 0.243 0.231 rg 0.0491 Tc 1.294 0 Td (salbutamol )Tj 0.05 Tc 10.18 0 0 9.9 311.53 471.12 Tm (but )Tj 0.0457 Tc 9.9 0 0 9.9 331.18 471.12 Tm (the )Tj 0.0223 Tc 1.891 0 Td (volume )Tj 0.0273 Tc 3.679 0 Td (inspired )Tj 0.001 Tc 4.031 0 Td (was )Tj 0.0415 Tc 2.126 0 Td (greater )Tj 0.05 Tc 9.9809 0 0 9.9 482.74 471.12 Tm (so )Tj 0.165 0.165 0.157 rg 0.0457 Tc 9.9 0 0 9.9 497.74 471.12 Tm (the )Tj 0.239 0.243 0.231 rg 0.0401 Tc 1.891 0 Td (mean )Tj 0.039 Tc -20.758 -1.067 Td (inspiratory )Tj 0.165 0.165 0.157 rg -0.0029 Tc 5.088 0 Td (flow )Tj 0.0348 Tc 2.24 0 Td (rate )Tj 0.239 0.243 0.231 rg 0.0252 Tc 1.988 0 Td (was )Tj 0.0237 Tc 1.932 0 Td (increased. )Tj 0.05 Tc 9.9723 0 0 9.9 468.39 460.56 Tm (The )Tj 0.0463 Tc 9.9 0 0 9.9 488.66 460.56 Tm (plateau )Tj 0.001 Tc 3.536 0 Td (was )Tj 0.0188 Tc -21.492 -1.114 Td (slightly )Tj 0.05 Tc 9.9156 0 0 9.9 346.9 449.53 Tm (shorter )Tj 10.2564 0 0 9.9 381.98 449.53 Tm (on )Tj 0.0338 Tc 9.9 0 0 9.9 397.82 449.53 Tm (average )Tj 0.05 Tc 10.15 0 0 9.9 435.37 449.53 Tm (by )Tj 9.9281 0 0 9.9 451.14 449.53 Tm (2.3%. )Tj 0.165 0.165 0.157 rg 10.2656 0 0 9.9 481.35 449.53 Tm (The )Tj 0.239 0.243 0.231 rg 0.0053 Tc 9.9 0 0 9.9 503.5 449.53 Tm (times )Tj 0.05 Tc 11.1292 0 0 9.9 530.77 449.53 Tm (of )Tj 0.0396 Tc 9.9 0 0 9.9 310.95 438.49 Tm (deadspace )Tj 0.05 Tc 10.0592 0 0 9.9 358.07 438.49 Tm (washout )Tj 10.3398 0 0 9.9 397.81 438.49 Tm (and )Tj 0.0405 Tc 9.9 0 0 9.9 417.46 438.49 Tm (sample )Tj 0.0227 Tc 3.398 0 Td (collection )Tj 0.0009 Tc 4.567 0 Td (were )Tj 0.05 Tc 10.264 0 0 9.9 519.37 438.49 Tm (both )Tj 0.0225 Tc 9.9 0 0 9.9 311.51 427.44 Tm (reduced)Tj 0.388 0.388 0.384 rg 0 Tc 3.38 0 Td (, )Tj 0.239 0.243 0.231 rg 0.011 Tc 0.984 0 Td (respectively )Tj 0.165 0.165 0.157 rg 0.0278 Tc 5.772 0 Td (by )Tj 0.239 0.243 0.231 rg 0.0266 Tc 1.856 0 Td (15.5% )Tj 0.05 Tc 10.3398 0 0 9.9 464.53 427.44 Tm (and )Tj 0.0269 Tc 9.9 0 0 9.9 488.52 427.44 Tm (39.4%; )Tj 0.05 Tc 10.2 0 0 9.9 526.06 427.44 Tm (the )Tj 0.0362 Tc 9.9 0 0 9.9 310.93 416.89 Tm (expiratory )Tj 0.165 0.165 0.157 rg -0.0191 Tc 4.848 0 Td (flow )Tj 0.239 0.243 0.231 rg 0.0379 Tc 2.192 0 Td (rates )Tj 0.0171 Tc 2.424 0 Td (were )Tj 0.0216 Tc 2.369 0 Td (increased )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.5807 0 0 12 471.27 416.89 Tm (in )Tj EMC ET BT /T1_0 1 Tf 0.0264 Tc 9.9 0 0 9.9 482.78 416.89 Tm (consequence. )Tj 0.0217 Tc -17.358 -1.116 Td (Overall )Tj 0.0215 Tc 3.451 0 Td (the )Tj 0.0394 Tc 1.494 0 Td (estimated )Tj 0.0458 Tc 4.424 0 Td (breath )Tj 0.0411 Tc 2.762 0 Td (holding )Tj 0.0236 Tc 3.587 0 Td (time )Tj 0.0252 Tc 2.086 0 Td (was )Tj 0.0306 Tc 1.891 0 Td (reduced )Tj 0.0209 Tc -19.695 -1.114 Td (following )Tj 0.0408 Tc 4.361 0 Td (salbutamol; )Tj 0.0457 Tc 5.442 0 Td (the )Tj 0.165 0.165 0.157 rg 0.0314 Tc 1.698 0 Td (reduction )Tj 0.239 0.243 0.231 rg 0.0252 Tc 4.412 0 Td (was )Tj 0.0143 Tc 1.975 0 Td (significantly )Tj 0.0334 Tc -17.885 -1.116 Td (greater )Tj 0.0377 Tc 3.342 0 Td (for )Tj 0.05 Tc 9.9182 0 0 9.9 359.98 383.76 Tm (method )Tj 0.165 0.165 0.157 rg 0 Tc 9.9 0 0 9.9 396.89 383.76 Tm (I )Tj 0.239 0.243 0.231 rg 0.0358 Tc 0.771 0 Td (\(5.3%\) )Tj 0.05 Tc 10.2803 0 0 9.9 437.25 383.76 Tm (than )Tj 0.0457 Tc 9.9 0 0 9.9 460.3 383.76 Tm (the )Tj 0.0494 Tc 1.689 0 Td (other )Tj 0.0425 Tc 2.626 0 Td (methods )Tj -0.0042 Tc -19.404 -1.066 Td (\(2.6)Tj 0.561 0.561 0.549 rg 0 Tc 1.552 0 Td (-)Tj 0.239 0.243 0.231 rg 0.0366 Tc 0.679 0 Td (3.7%\). )Tj 0.05 Tc 9.9723 0 0 9.9 364.71 373.21 Tm (The )Tj 0.0327 Tc 9.9 0 0 9.9 384.38 373.21 Tm (changes )Tj 0.05 Tc 9.9087 0 0 9.9 421.82 373.21 Tm (are )Tj 0.029 Tc 9.9 0 0 9.9 438.64 373.21 Tm (illustrated )Tj 0.05 Tc 10.0636 0 0 9.9 484.72 373.21 Tm (in )Tj 0.0038 Tc 9.9 0 0 9.9 496.21 373.21 Tm (figure )Tj /T1_2 1 Tf -0.035 Tc 8.1087 0 0 9.7 524.86 373.21 Tm (1. )Tj 0.165 0.165 0.157 rg 0.0266 Tc 8.7 0 0 8.7 61.38 352.56 Tm (Table )Tj -0.035 Tc 8.2732 0 0 9.4 87.13 352.56 Tm (I.)Tj 0.31 0.31 0.298 rg 0 Tc 9.4 0 0 9.4 94.48 352.56 Tm (-)Tj 0.165 0.165 0.157 rg 0.0273 Tc 8.7 0 0 8.7 100.13 352.56 Tm (Mean )Tj 0.0192 Tc 2.887 0 Td (values )Tj 0.239 0.243 0.231 rg 0.0053 Tc 3.303 0 Td (and )Tj 0.0206 Tc 2.033 0 Td (ranges )Tj 0.0477 Tc 3.437 0 Td (for )Tj 0.0379 Tc 1.538 0 Td (some )Tj 0.165 0.165 0.157 rg 0.0122 Tc 2.859 0 Td (indices )Tj 0.239 0.243 0.231 rg 0.0183 Tc 3.486 0 Td (describing )Tj 0.05 Tc 8.7476 0 0 8.7 313.4 352.56 Tm (the )Tj 0.165 0.165 0.157 rg 0.0239 Tc 8.7 0 0 8.7 329.48 352.56 Tm (18 )Tj 0.239 0.243 0.231 rg 0.0229 Tc 1.402 0 Td (subjects )Tj 0.165 0.165 0.157 rg 0.05 Tc 8.7004 0 0 8.7 377.28 352.56 Tm (who )Tj 0.239 0.243 0.231 rg 0.0253 Tc 8.7 0 0 8.7 396.38 352.56 Tm (completed )Tj 0.165 0.165 0.157 rg 0.0265 Tc 5.138 0 Td (the )Tj 0.239 0.243 0.231 rg 0.0116 Tc 1.761 0 Td (study. )Tj 0.165 0.165 0.157 rg 0.0283 Tc 3.037 0 Td (The )Tj 0.239 0.243 0.231 rg 0.0084 Tc 2.14 0 Td (results )Tj 0.0201 Tc -50.577 -1.268 Td (for )Tj 0.0252 Tc 1.488 0 Td (ventilatory )Tj 0.0221 Tc 5.068 0 Td (capacity )Tj 0.165 0.165 0.157 rg 0.0065 Tc 4.139 0 Td (are )Tj 0.239 0.243 0.231 rg 0.0306 Tc 1.711 0 Td (given )Tj 0.165 0.165 0.157 rg 0.0244 Tc 2.803 0 Td (before )Tj 0.239 0.243 0.231 rg 0.0329 Tc 3.264 0 Td (and )Tj 0.165 0.165 0.157 rg 0.0165 Tc 2.041 0 Td (after )Tj 0.239 0.243 0.231 rg 0.0169 Tc 2.374 0 Td (salbutamol )Tj /T1_0 1 Tf 0.0064 Tc 8.9 0 0 8.9 61.42 297.84 Tm (Age )Tj 0.165 0.165 0.157 rg /T1_2 1 Tf 0.05 Tc 9.321 0 0 8.5 60.92 286.81 Tm (yr )Tj ET BT /Suspect <>BDC 0.239 0.243 0.231 rg /T1_0 1 Tf 0.0107 Tc 8.9 0 0 8.9 61.28 264.72 Tm (Stature )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 60.9418 254.1557 Tm (m )Tj 0.165 0.165 0.157 rg 0.0403 Tc -0.056 -2.48 Td (Body )Tj 0.239 0.243 0.231 rg 0.0007 Tc 2.537 0 Td (mass )Tj 0.165 0.165 0.157 rg 0.0256 Tc -2.535 -1.24 Td (kg )Tj 0.0309 Tc -0.002 -4.962 Td (Forced )Tj 0.239 0.243 0.231 rg 0.0134 Tc 3.069 0 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Tf 0.0156 Tc 9 0 0 9 350.3 536.41 Tm (3.78 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0105 Tc 9 0 0 9 421.832 535.924 Tm (0.82 )Tj EMC /Suspect <>BDC -0.0084 Tc 6.109 0.054 Td (10.1 )Tj EMC ET BT /T1_0 1 Tf 0.0039 Tc 9 0 0 9 50.843 514.333 Tm (Residual )Tj 0.0097 Tc 3.789 0 Td (volume )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.05 Tc 9.7174 0 0 8.8 222.59 513.85 Tm (RV,l )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.0096 Tc 9 0 0 9 350.35 514.33 Tm (2.90 )Tj EMC /Suspect <>BDC -0.0072 Tc 7.942 0 Td (0.91 )Tj EMC ET BT 0.255 0.259 0.255 rg /T1_0 1 Tf 0.05 Tc 9.1368 0 0 9 471.73 514.33 Tm (-12.6 )Tj 0.106 0.11 0.102 rg 0.0107 Tc 9 0 0 9 50.32 492.25 Tm (Total )Tj 0.176 0.176 0.173 rg 0.0172 Tc 2.4 0 Td (lung )Tj 0.0077 Tc 2.079 0 Td (capacity )Tj 0.106 0.11 0.102 rg 0.05 Tc 9.6128 0 0 9 221.68 492.25 Tm (TLC,/ )Tj 0.176 0.176 0.173 rg 0.0115 Tc 9 0 0 9 350.29 492.25 Tm (6.68 )Tj -0.0084 Tc 8.031 0 Td (1.37 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0105 Tc 9 0 0 9 480.871 492.25 Tm (0.32 )Tj EMC /Suspect <>BDC -0.035 Tc 7.9117 0 0 8.9 506.31 492.25 Tm (\(NS\) )Tj EMC /Suspect <>BDC /T1_1 1 Tf 0 Tc 12.2 0 0 12.2 50.77 470.16 Tm (* )Tj EMC ET BT /T1_0 1 Tf 0.0373 Tc 7.8001 0 0 7.8001 56.62 470.16 Tm (the )Tj 0.0209 Tc 1.532 0 Td (changes )Tj 0.0314 Tc (were )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0178 Tc 7.8001 0 0 7.8001 115.0895 470.16 Tm (significant )Tj EMC ET BT /T1_0 1 Tf 0.0366 Tc 7.8001 0 0 7.8001 151.1182 470.16 Tm (except )Tj 0.106 0.11 0.102 rg 0.0216 Tc 3.024 0 Td (where )Tj 0.176 0.176 0.173 rg 0.0137 Tc 2.824 0 Td (indicated )Tj 0.0406 Tc 3.997 0 Td (as )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 7.9515 0 0 7.8001 236.68 470.16 Tm (NS )Tj EMC ET BT /T1_0 1 Tf 0.0235 Tc 7.8001 0 0 7.8001 249.51 470.16 Tm (\(not )Tj 0.0139 Tc 1.967 0 Td (significant\) )Tj 0.106 0.11 0.102 rg /T1_1 1 Tf 0.0266 Tc 8.7 0 0 8.7 49.38 438.49 Tm (Table )Tj ET BT /Suspect <>BDC 0.176 0.176 0.173 rg /T1_1 1 Tf 0.035 Tc 8.7 0 0 8.7 74.6361 438.49 Tm (Ill. )Tj EMC ET BT 0.106 0.11 0.102 rg /T1_1 1 Tf 0 Tc 8.7 0 0 8.7 86.7987 438.49 Tm (-)Tj 0.176 0.176 0.173 rg 0.0238 Tc 0.644 0 Td (Indices )Tj 0.0156 Tc 3.549 0 Td (of )Tj 0.05 Tc 8.8453 0 0 8.7 132.88 438.49 Tm (gas )Tj 0.0294 Tc 8.7 0 0 8.7 149.72 438.49 Tm (transfer )Tj 0.0244 Tc 3.847 0 Td (before )Tj 0.0329 Tc 3.209 0 Td (and )Tj 0.0302 Tc 1.986 0 Td (after )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0206 Tc 8.7 0 0 8.7 248.552 438.49 Tm (salbutamol. )Tj EMC ET BT /T1_1 1 Tf 0.0273 Tc 8.7 0 0 8.7 299.8037 438.49 Tm (Mean )Tj 0.0303 Tc 2.777 0 Td (values )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0016 Tc 8.8 0 0 8.8 353.13 438.49 Tm (\(sl\) )Tj EMC ET BT /T1_1 1 Tf 0.0329 Tc 8.7 0 0 8.7 367.59 438.49 Tm (and )Tj 0.02 Tc 1.993 0 Td (variability )Tj 0.0485 Tc 4.676 0 Td (\(%\)within )Tj 0.0329 Tc 4.807 0 Td (and )Tj 0.024 Tc 2.032 0 Td (between\255)Tj 0.0422 Tc -50.086 -1.214 Td (days )Tj /T1_0 1 Tf 0.0154 Tc 9 0 0 9 200.12 405.37 Tm (Before )Tj 0.0077 Tc 2.977 0 Td (salbutamol )Tj 0.0078 Tc 19.799 0.052 Td (After )Tj 0.0077 Tc 2.388 0 Td (salbutamol )Tj 0.0008 Tc -19.988 -2.453 Td (variability )Tj 0.0062 Tc 22.133 0.054 Td (variability )Tj 0.008 Tc -44.111 -2.507 Td (Index )Tj 0.0096 Tc 6.402 0 Td (Method )Tj 0.0271 Tc 6.349 0 Td (mean )Tj 0.013 Tc 6.348 0 Td (within )Tj 0.0069 Tc 6.349 0 Td (between )Tj 0.0094 Tc 9.117 0 Td (mean )Tj 0.106 0.11 0.102 rg 0.0023 Tc 6.774 0.052 Td (within )Tj 0.176 0.176 0.173 rg 0.0069 Tc 7.096 0 Td (between )Tj /T1_1 1 Tf 0 Tc -41.953 -2.56 Td (1 )Tj /T1_0 1 Tf 0.0094 Tc 6.344 0.054 Td (1.12 )Tj 0.0131 Tc 1.942 0 Td (\(4\) )Tj 0.0226 Tc 4.328 0 Td (4.2 )Tj -0.0212 Tc 6.338 -0.054 Td (5.1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0094 Tc 9 0 0 9 357.782 340.084 Tm (1.10 )Tj EMC ET BT /T1_0 1 Tf 0.0131 Tc 9 0 0 9 375.746 340.084 Tm (\(2\) )Tj 0.0068 Tc 5.014 -0.053 Td (3.3 )Tj 7.093 0 Td (3.6 )Tj 0.106 0.11 0.102 rg /T1_1 1 Tf 0.05 Tc 9.0692 0 0 9 48.77 328.56 Tm (Kco )Tj 0.176 0.176 0.173 rg /T1_0 1 Tf 0 Tc 9 0 0 9 106.51 328.56 Tm (2 )Tj 0.0094 Tc 6.371 0 Td (1.12 )Tj 0.0131 Tc 1.996 0 Td (\(4\) )Tj 0.0226 Tc 4.274 0 Td (4.9 )Tj -0.0212 Tc 6.391 0 Td (5.8 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0094 Tc 9 0 0 9 357.772 328.56 Tm (1.08 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.4531 0 0 9 375.73 328.56 Tm (\(4\)t )Tj 0.0068 Tc 9 0 0 9 420.86 328.56 Tm (3.6 )Tj 0.255 0.259 0.255 rg 0.0226 Tc 7.047 0.054 Td (4.3 )Tj 0.176 0.176 0.173 rg 0 Tc -42.033 -1.333 Td (3 )Tj 0.106 0.11 0.102 rg -0.0084 Tc 6.43 0.053 Td (1.21 )Tj 0.176 0.176 0.173 rg 0.0131 Tc 1.996 0 Td (\(1\) )Tj 0.0226 Tc 4.274 0 Td (4.6 )Tj 0.0054 Tc 6.338 -0.053 Td (5.3 )Tj 0.0094 Tc 8.939 0.053 Td (1.16 )Tj 0.05 Tc 11.0133 0 0 9 375.71 317.53 Tm (\(l\)t )Tj 0.0068 Tc 9 0 0 9 420.86 317.53 Tm (3.4 )Tj 7.093 0 Td (3.8 )Tj 0 Tc -42.073 -1.227 Td (4 )Tj 0.0094 Tc 6.423 0 Td (1.14 )Tj 0.0131 Tc 1.996 0 Td (\(2\) )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.044 Tc 9 0 0 9 220.277 305.524 Tm (4.3* )Tj EMC /Suspect <>BDC 0.0054 Tc 6.391 0.052 Td (5.0 )Tj EMC ET BT /T1_0 1 Tf -0.0262 Tc 9 0 0 9 357.77 306.478 Tm (1.11 )Tj 0.05 Tc 9.4531 0 0 9 375.73 306.49 Tm (\(2\)t )Tj 0.0068 Tc 9 0 0 9 420.86 306.49 Tm (3.3 )Tj 7.093 0 Td (3.7 )Tj /T1_1 1 Tf 0 Tc 8.4 0 0 8.4 106.77 284.41 Tm (1 )Tj /T1_0 1 Tf 0.0115 Tc 9 0 0 9 163.57 284.41 Tm (6.99 )Tj 0.0131 Tc 2.027 0 Td (\(4\) )Tj -0.004 Tc 4.274 0 Td (4.8 )Tj 0.0321 Tc 6.338 0 Td (5.9 )Tj -0.024 Tc 9.174 0.053 Td (6.91 )Tj 0.0131 Tc 2.027 0 Td (\(2\) )Tj 0.0068 Tc 4.748 0 Td (3.8 )Tj -0.004 Tc 7.047 0 Td (4.8 )Tj 0 Tc -42.028 -1.28 Td (2 )Tj -0.0062 Tc 6.393 0.052 Td (6.93 )Tj 0.0131 Tc 2.027 0 Td (\(4\) )Tj 0 Tc 4.266 -0.052 Td (5)Tj 0 g 0.579 0 Td (.)Tj 0.176 0.176 0.173 rg 0.229 0 Td (2 )Tj 0.0006 Tc 5.593 0 Td (6.2 )Tj 0 Tc 9.067 0.052 Td (6)Tj 0.341 0.341 0.333 rg 0.578 0 Td (.)Tj 0.176 0.176 0.173 rg -0.035 Tc 8.6773 0 0 9 366.63 273.84 Tm (71 )Tj 0.05 Tc 9.758 0 0 9 377.64 273.84 Tm (\(4\)t )Tj 0.0068 Tc 9 0 0 9 420.86 273.84 Tm (3.9 )Tj 0.106 0.11 0.102 rg 0.0226 Tc 7.047 0 Td (4.9 )Tj /T1_1 1 Tf 0.05 Tc 9.8718 0 0 8.8 48.42 262.33 Tm (TI )Tj 0.176 0.176 0.173 rg /T1_0 1 Tf 0 Tc 9 0 0 9 105.98 262.33 Tm (3 )Tj 0.0115 Tc 6.4 0.053 Td (7.54 )Tj 0.0131 Tc 2.026 0 Td (\(1\) )Tj 0.0321 Tc 4.266 -0.053 Td (5.3 )Tj 0.0006 Tc 6.401 0 Td (6.2 )Tj 0.0115 Tc 9.068 0.053 Td (7.25 )Tj 0.05 Tc 9.758 0 0 9 377.64 262.81 Tm (\(1\)t )Tj 0.0335 Tc 9 0 0 9 420.38 262.81 Tm (3.8 )Tj 0.0226 Tc 7.1 0 Td (4.9 )Tj 0 Tc -42.08 -1.28 Td (4 )Tj 0.0293 Tc 6.393 0.052 Td (7.12 )Tj 0.255 0.259 0.255 rg -0.0135 Tc 2.079 0 Td (\(2\) )Tj ET BT /Suspect <>BDC 0.176 0.176 0.173 rg /T1_0 1 Tf 0.044 Tc 9 0 0 9 220.274 250.795 Tm (4.7* )Tj EMC ET BT /T1_0 1 Tf 0.0054 Tc 9 0 0 9 277.316 251.281 Tm (5.3 )Tj 0.0115 Tc 9.121 0.052 Td (6.92 )Tj 0.05 Tc 9.4531 0 0 9 377.65 251.76 Tm (\(2\)t )Tj 0.0335 Tc 9 0 0 9 420.38 251.76 Tm (3.7 )Tj 0.106 0.11 0.102 rg -0.004 Tc 7.1 0 Td (4.5 )Tj 0 Tc -42.003 -2.506 Td (1 )Tj ET BT /Suspect <>BDC 0.176 0.176 0.173 rg /T1_0 1 Tf -0.0062 Tc 9 0 0 9 163.574 229.683 Tm (6.20 )Tj EMC ET BT /T1_0 1 Tf 0.0131 Tc 9 0 0 9 181.331 229.683 Tm (\(4\) )Tj 0.0147 Tc 4.319 0 Td (5.4* )Tj 0.0006 Tc 6.348 0 Td (6.3 )Tj -0.0062 Tc 9.12 0.052 Td (6.27 )Tj 0.0131 Tc 2.027 0 Td (\(2\) )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0084 Tc 9 0 0 9 420.443 229.683 Tm (4.4* )Tj EMC ET BT /T1_0 1 Tf -0.003 Tc 9 0 0 9 484.199 229.683 Tm (5.8* )Tj 0 Tc 10 0 0 10 105.54 218.16 Tm (2 )Tj 0.0115 Tc 9 0 0 9 163.09 218.65 Tm (6.14 )Tj 0.0131 Tc 2.027 0 Td (\(4\) )Tj 0.0321 Tc 4.319 -0.054 Td (5.6 )Tj 0 Tc 6.348 0.054 Td (6)Tj 0.341 0.341 0.333 rg 0.524 0 Td (.)Tj 0.176 0.176 0.173 rg 0.223 0 Td (9 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0115 Tc 9 0 0 9 359.407 218.65 Tm (6.09 )Tj EMC ET BT /T1_0 1 Tf 0.0131 Tc 9 0 0 9 377.65 218.65 Tm (\(4\) )Tj 0.0084 Tc 4.754 0.053 Td (4.7* )Tj -0.0062 Tc 7.139 -0.053 Td (6.2* )Tj /T1_1 1 Tf 0.0298 Tc 9.4 0 0 9.4 47.94 207.13 Tm (TI' )Tj /T1_0 1 Tf 0 Tc 9 0 0 9 105.5 207.13 Tm (3 )Tj 0.0115 Tc 6.399 0.053 Td (6.67 )Tj -0.0135 Tc 2.027 0 Td (\(1\) )Tj 0.0321 Tc 4.319 -0.053 Td (5.2 )Tj 0.0006 Tc 6.348 0 Td (6.2 )Tj -0.0062 Tc 9.12 0.107 Td (6.57 )Tj 0.255 0.259 0.255 rg 0.0131 Tc 2.027 0 Td (\(1\) )Tj 0.176 0.176 0.173 rg 0.0084 Tc 4.754 0 Td (4.4* )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.003 Tc 9 0 0 9 484.202 207.616 Tm (5.8* )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.3 0 0 9.3 105.56 196.57 Tm (4 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0115 Tc 9 0 0 9 163.09 196.57 Tm (6.30 )Tj EMC ET BT /T1_0 1 Tf 0.0131 Tc 9 0 0 9 181.333 196.57 Tm (\(2\) )Tj -0.0212 Tc 4.319 0 Td (5.3 )Tj -0.026 Tc 6.348 0 Td (6.3 )Tj -0.0062 Tc 9.12 0.053 Td (6.28 )Tj 0.0131 Tc 2.027 0 Td (\(2\) )Tj 0.0226 Tc 4.701 -0.373 Td (4.3 )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 11.3899 0 0 16.2001 433.53 193.69 Tm (*"' )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.0325 Tc 9 0 0 9 484.2 196.09 Tm (5.3* )Tj EMC ET BT /T1_0 1 Tf 0.0281 Tc 9 0 0 9 48.456 174.49 Tm (tsignificant )Tj 0.0142 Tc 5.219 0 Td (change )Tj 0.0122 Tc 3.413 0 Td (after )Tj 0.0077 Tc 2.342 0 Td (salbutamol )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0009 Tc 9 0 0 9 191.88 174.49 Tm (\(p<0.05\) )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9 0 0 9 225.45 174.49 Tm [(, )-250(\( )]TJ 9 0 0 9 484.2 196.09 Tm -27.408 -2.4 Td (\) )Tj 0.0076 Tc 0.846 0 Td (significant )Tj 0.0245 Tc 4.751 0 Td (order )Tj 0.0189 Tc 2.346 0 Td (effect )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0086 Tc 9 0 0 9 336.843 174.49 Tm (\(p<0.05\) )Tj EMC ET BT /T1_0 1 Tf 0.0045 Tc 9 0 0 9 373.365 174.49 Tm (indicated )Tj 0.0229 Tc 3.956 0 Td (by )Tj 0.0047 Tc 1.491 0 Td (numbers )Tj 0.0023 Tc 4 0 Td (within )Tj 0.0006 Tc 3.096 0 Td (brackets, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9 0 0 9 48.294 163.933 Tm (* )Tj EMC ET BT /T1_0 1 Tf 0.0082 Tc 9 0 0 9 55.557 163.933 Tm (significantly )Tj 0.0112 Tc 5.339 0 Td (different )Tj 0.0037 Tc 3.838 0 Td (from )Tj 0.0062 Tc 2.302 0 Td (variability )Tj -0.0326 Tc 4.524 0 Td (for )Tj 0.106 0.11 0.102 rg /T1_1 1 Tf 0.0167 Tc 1.43 0 Td (Kco, )Tj ET BT /Suspect <>BDC 0.176 0.176 0.173 rg /T1_2 1 Tf 0 Tc 15.6 0 0 15.6 236.59 163.93 Tm (* )Tj EMC ET BT /T1_0 1 Tf 0.0076 Tc 9 0 0 9 245.15 163.93 Tm (significant )Tj 0.0075 Tc 4.539 0 Td (difference )Tj 0.0116 Tc 4.426 0 Td (compared )Tj 0.0139 Tc 4.329 0 Td (with )Tj 0.0095 Tc 2.132 0 Td (method )Tj -0.035 Tc 8.9643 0 0 9 414.19 163.93 Tm (2. )Tj 0.106 0.11 0.102 rg 0.0335 Tc 9 0 0 9 423.76 163.93 Tm (TI )Tj 0.176 0.176 0.173 rg -0.0226 Tc 1.332 0 Td (and )Tj 0.0334 Tc 1.708 0 Td (TI' )Tj 0.014 Tc 1.5 0 Td (transfer )Tj -0.0029 Tc 3.404 0 Td (factors )Tj 0.009 Tc -49.706 -1.227 Td (calculated )Tj 0.0037 Tc 4.372 0 Td (from )Tj 0.0069 Tc 2.241 0 Td (alveolar )Tj 0.0055 Tc 3.528 0 Td (volumes )Tj 0.0075 Tc 3.681 0 Td (respectively )Tj 0.01 Tc 5.119 0 Td (measured )Tj 0.0037 Tc 4.098 0 Td (from )Tj 0.004 Tc 2.249 0 Td [(multibreath )10(and )]TJ 0.0079 Tc 6.601 0 Td (single )Tj 0.106 0.11 0.102 rg 0.0254 Tc 2.629 0 Td (breath )Tj 0.255 0.259 0.255 rg 0.0067 Tc 2.823 0 Td (techniques. )Tj 0.106 0.11 0.102 rg /T1_3 1 Tf -0.035 Tc 10.599 0 0 10.7 133.4 126.96 Tm (Discussion )Tj 0.176 0.176 0.173 rg /T1_0 1 Tf 0.0394 Tc 10.4 0 0 10.4 51.27 110.64 Tm (The )Tj 0.255 0.259 0.255 rg 0.006 Tc 1.887 0 Td (single-breath )Tj 0.176 0.176 0.173 rg 0.021 Tc (procedure )Tj 0.0074 Tc 9.972 0 Td (for )Tj 0.0111 Tc 1.487 0 Td (measuring )Tj 0.0194 Tc 4.522 0 Td (transfer )Tj 0.106 0.11 0.102 rg 0.0196 Tc -18.793 -1.062 Td (factor )Tj 0.176 0.176 0.173 rg -0.0072 Tc 2.633 0 Td (devised )Tj -0.0212 Tc 3.288 0 Td (by )Tj 0.106 0.11 0.102 rg 0.0411 Tc 7.8001 0 0 7.8001 116.13 99.6 Tm (FORSTER )Tj 0.255 0.259 0.255 rg /T1_4 1 Tf 0.0357 Tc 9.7 0 0 9.7 154.95 99.6 Tm (et )Tj 0.176 0.176 0.173 rg -0.0142 Tc 1.042 0 Td (a/. )Tj /T1_0 1 Tf 0.0098 Tc 10.4 0 0 10.4 177.59 99.6 Tm (was )Tj 0 Tc 1.79 0 Td (a )Tj 0.0274 Tc 0.701 0 Td (minor )Tj 0.0057 Tc 2.768 0 Td (technical )Tj -0.001 Tc -18.322 -1.061 Td (masterpiece )Tj -0.035 Tc 9.5041 0 0 10.4 96.73 88.57 Tm ([3] )Tj 0.05 Tc 10.531 0 0 10.4 112.81 88.57 Tm (but )Tj 0.042 Tc 10.4 0 0 10.4 132.47 88.57 Tm (had )Tj 0.01 Tc 2.069 0 Td (limitations. )Tj ET BT /Suspect <>BDC 0.106 0.11 0.102 rg /T1_0 1 Tf 0.0325 Tc 10.4 0 0 10.4 207.7348 88.57 Tm (One )Tj EMC ET BT 0.176 0.176 0.173 rg /T1_0 1 Tf -0.0132 Tc 10.4 0 0 10.4 231.3428 88.57 Tm (was )Tj 0.0402 Tc 2.075 0 Td (that )Tj -0.0022 Tc 4.019 4.292 Td (because )Tj 0.022 Tc 3.775 0 Td (inspiration )Tj 0.0456 Tc 5.167 0 Td (and )Tj 0.0137 Tc 2.215 0 Td (expiration )Tj 0.0269 Tc 4.847 0 Td (could )Tj 0.05 Tc 10.4827 0 0 10.4 491.99 133.21 Tm (not )Tj -0.0103 Tc 10.4 0 0 10.4 513.61 133.21 Tm (be )Tj 0.0213 Tc -21.102 -1.062 Td (instantaneous )Tj 0.0373 Tc 6.19 0 Td (the )Tj 0.0161 Tc 1.802 0 Td (relationship )Tj -0.0094 Tc 5.4 0 Td (which )Tj 0.0015 Tc 2.899 0 Td (described )Tj 0.0106 Tc 4.386 0 Td (gas )Tj 0.0306 Tc -20.668 -1.062 Td (uptake )Tj 0.0244 Tc 3.037 0 Td (during )Tj 0.0229 Tc 2.964 0 Td (breathholding )Tj -0.0132 Tc 6.044 0 Td (was )Tj 0.106 0.11 0.102 rg 0.013 Tc 1.744 0 Td (assumed )Tj 0.176 0.176 0.173 rg 0.01 Tc 3.792 0 Td (to )Tj 0.0131 Tc 1.054 0 Td (apply )Tj 0.01 Tc 2.546 0 Td (to )Tj 0.0143 Tc -21.185 -1.062 Td (the )Tj 0.0022 Tc 1.571 0 Td (whole )Tj 0.05 Tc 11.1292 0 0 10.4 339.25 100.08 Tm (of )Tj 0.0143 Tc 10.4 0 0 10.4 351.81 100.08 Tm (the )Tj 0.0149 Tc 1.617 0 Td (respiratory )Tj -0.0241 Tc 4.791 0 Td (cycle. )Tj 0.0394 Tc 2.586 0 Td (The )Tj 0.0137 Tc 1.937 0 Td (alternative )Tj 0.05 Tc 11.1292 0 0 10.4 514.45 100.08 Tm (of )Tj 0.0196 Tc 10.4 0 0 10.4 294.21 89.52 Tm (treating )Tj 0.022 Tc 3.41 0 Td (inspiration )Tj 0.0456 Tc 4.752 0 Td (and )Tj 0.0189 Tc 1.8 0 Td (expiration )Tj 0.0094 Tc 4.473 0 Td (separately )Tj -0.0132 Tc 4.398 0 Td (was )Tj 0.0324 Tc 1.8 0 Td (not )Tj ET endstream endobj 28 0 obj <>stream jP ftypjp2 jp2 jpxbjpx rreq@ --jp2hihdrcolrjp2cOQ/R \#B@HHPHHPHHPHHP((( ߇C ̃ fAC§O R]kQ. _@ $%~i&@0fr,gT$9PWmO_VpuƯw_)*^|C !aqgjY<~3Э:(0mH@90 X>@WJQVpl/!5vԸ;nϨtwhkI'f&x7p|<AcyPcN{~${M QhH=rKGȊ̸Vo6X1Qu3FDqS 9s9s9s\ @ۂ̕/%#7Fw'؜(Zc2hR˧y4hc=/\7OIo:%VPٲegYG膳JmDeuhWZQȺ:iW>=}SmK`\aUXϘ鎏fL9,ebgN3̰G剛rlKZ7G7z1qV ?Ȝ,'8W~fNЪ( A@ ʱ;'1XW*-ZiY?YTþtݯإcqY );scx c9T龭Ҥ9> 已kc юGZ,[r'v :?6o9 .Dh cc 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(Alveolar )Tj 0.0307 Tc 3.862 0 Td (volume )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.2146 0 0 8.7 125.74 630 Tm (VA )Tj EMC ET BT /T1_0 1 Tf 0.0296 Tc 8.7 0 0 8.7 61.9 607.92 Tm (Alveolar )Tj 0.0307 Tc 3.917 0 Td (volume )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.0653 0 0 8.7 125.74 607.92 Tm (VA' )Tj EMC /Suspect <>BDC 8.4986 0 0 8.7 61.9 586.33 Tm (VA'\(VA )Tj EMC ET BT /T1_0 1 Tf 0.0225 Tc 8.7 0 0 8.7 61.37 562.8 Tm (Times: )Tj 0.0267 Tc 0 -2.482 TD (inspiration )Tj 0 Tc 9.87 0 Td (s )Tj 0.0359 Tc -9.916 -2.539 Td (plateau )Tj 0 Tc 9.861 0 Td (s )Tj 0.0261 Tc -9.871 -2.593 Td (deadspace )Tj 0.0249 Tc 4.587 0 Td (washout )Tj 0 Tc 5.284 0 Td (s )Tj 0.0242 Tc -9.876 -2.537 Td (sampling )Tj 0 Tc 9.876 0 Td (s )Tj 0.0266 Tc -9.922 -2.593 Td (Breathholding )Tj 0.012 Tc 6.292 0 Td (time: )Tj 0.0313 Tc -6.292 -2.539 Td (Method )Tj 0 Tc 3.556 0 Td (1 )Tj 9.8 0 0 9.8 146.74 429.37 Tm (s )Tj 0.0313 Tc 8.7 0 0 8.7 60.44 408.25 Tm (Method )Tj 0 Tc 3.475 0 Td (2 )Tj 9.3 0 0 9.3 146.27 407.76 Tm (s )Tj 0.05 Tc 8.8651 0 0 8.7 60.44 386.16 Tm (Method3 )Tj 0 Tc 9.3 0 0 9.3 146.27 385.69 Tm (s )Tj 0.05 Tc 8.9882 0 0 8.7 60.44 364.09 Tm (Method4 )Tj /T1_2 1 Tf 0 Tc 9.7 0 0 9.7 146.43 363.61 Tm (s )Tj /T1_0 1 Tf 0.0196 Tc 8.7 0 0 8.7 60.44 331.44 Tm (Flow )Tj 0.0116 Tc 2.376 0 Td (rates )Tj ET BT /Suspect <>BDC 0.078 0.078 0.071 rg /T1_2 1 Tf -0.035 Tc 8.8532 0 0 9 141.5 331.44 Tm (l\267)Tj 0.196 0.196 0.188 rg 8.8126 0 0 9 146.43 331.44 Tm (s\267)Tj 0.078 0.078 0.071 rg /T1_3 1 Tf 0 Tc 5.5001 0 0 5.5001 151.92 334.33 Tm (1 )Tj EMC ET BT 0.196 0.196 0.188 rg /T1_0 1 Tf 0.0209 Tc 8.7 0 0 8.7 59.94 308.41 Tm (Inspiratory )Tj 0.0171 Tc 0.056 -2.648 Td (Expiratory )Tj 0.0344 Tc -0.053 -2.539 Td (Washout )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0367 Tc 8.7 0 0 8.7 59.8356 240.2542 Tm (Sample )Tj EMC /Suspect <>BDC 0.0359 Tc 16.669 49.766 Td (3.30 )Tj EMC /Suspect <>BDC 0.0299 Tc 0.006 -2.539 Td (2.30 )Tj EMC ET BT /T1_0 1 Tf 0.0134 Tc 8.7 0 0 8.7 204.8472 629.5357 Tm (6.38 )Tj 0.0166 Tc -0.056 -2.539 Td (5.61 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0124 Tc 8.7 0 0 8.7 204.3861 585.853 Tm (0.88 )Tj EMC /Suspect <>BDC 0.0483 Tc -0.051 -5.131 Td (2.20 )Tj EMC /Suspect <>BDC -0.0329 Tc 9.8 0 0 9.8 203.83 519.12 Tm (8.00 )Tj EMC /Suspect <>BDC 0 Tc 8.7 0 0 8.7 203.91 496.09 Tm (0)Tj 0.078 0.078 0.071 rg 0.541 0 Td (.)Tj 0.196 0.196 0.188 rg 0.05 Tc 8.8968 0 0 8.7 210.14 496.09 Tm (96 )Tj EMC ET BT /T1_0 1 Tf 0.0106 Tc 8.7 0 0 8.7 204.18 474 Tm (1.44 )Tj -0.055 -5.076 Td (11.1 )Tj 0.0333 Tc 2.064 0 Td (\(4\) )Tj 0.029 Tc -2.064 -2.538 Td (11.2 )Tj -0.0135 Tc 9 0 0 9 221.65 407.76 Tm (\(4\) )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.829 0 0 8.7 203.69 385.69 Tm (10)Tj 0.078 0.078 0.071 rg 0 Tc 8.7 0 0 8.7 212.46 385.69 Tm (.)Tj 0.196 0.196 0.188 rg 0.23 0 Td (3 )Tj EMC ET BT /T1_0 1 Tf 0.0058 Tc 8.7 0 0 8.7 221.6646 385.69 Tm (\(1\) )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0106 Tc 8.7 0 0 8.7 203.7078 364.0879 Tm (10.9 )Tj EMC ET BT /T1_0 1 Tf 0.0058 Tc 8.7 0 0 8.7 221.6646 364.0879 Tm (\(2\) )Tj 0.0106 Tc -2.064 -6.455 Td (1.68 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0196 Tc 9.2 0 0 9.2 203.43 285.37 Tm (0.94 )Tj EMC /Suspect <>BDC 0.029 Tc 8.7 0 0 8.7 203.22 262.81 Tm (1.08 )Tj EMC /Suspect <>BDC 0.0308 Tc -0.031 -2.593 Td (0.89 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.7732 0 0 8.7 261.5 673.21 Tm (3.2 )Tj -0.0058 Tc 8.7 0 0 8.7 261.49 651.12 Tm (6.5 )Tj 0.0176 Tc 0.033 -2.482 Td (1.7 )Tj 0 Tc 9.2 0 0 9.2 261.07 607.44 Tm (2)Tj 0.078 0.078 0.071 rg 0.559 0 Td (.)Tj 0.196 0.196 0.188 rg 0.166 0 Td (7 )Tj -0.0155 Tc -0.725 -2.347 Td (2.7 )Tj 0.0106 Tc 8.7 0 0 8.7 261.3 541.21 Tm (16.7 )Tj 0.0447 Tc -0.08 -2.539 Td (4.4 )Tj -0.0078 Tc 0.08 -2.647 Td (12.1 )Tj 0.029 Tc -0.055 -2.539 Td (18.6 )Tj -0.0155 Tc 9.2 0 0 9.2 260.59 429.84 Tm (2.8 )Tj 0.0189 Tc 8.7 0 0 8.7 260.11 407.76 Tm (2.3 )Tj 0 Tc 0 -2.537 TD (2)Tj 0.078 0.078 0.071 rg 0.592 0 Td (.)Tj 0.196 0.196 0.188 rg 0.18 0 Td (2 )Tj 0.0189 Tc -0.772 -2.538 Td (2.5 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.029 Tc 8.7 0 0 8.7 260.8234 307.9275 Tm (16.0 )Tj EMC ET BT /T1_0 1 Tf -0.0204 Tc 9.2 0 0 9.2 260.8 285.37 Tm (12.9 )Tj -0.035 Tc 9.1511 0 0 9.2 260.8 262.81 Tm (12.1 )Tj 0.0106 Tc 8.7 0 0 8.7 260.82 240.25 Tm (18.6 )Tj 0.0266 Tc 6.641 49.766 Td (5.7 )Tj 0.0447 Tc -0.046 -2.483 Td (4.4 )Tj -0.0174 Tc 9.2 0 0 9.2 317.72 629.53 Tm (4.1 )Tj 0.0171 Tc 8.7 0 0 8.7 317.72 607.44 Tm (4.1 )Tj 0.05 Tc 8.7552 0 0 8.7 317.64 585.85 Tm (5.6 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0189 Tc 8.7 0 0 8.7 317.71 541.21 Tm (20.)Tj 0.078 0.078 0.071 rg 0 Tc 1.351 0 Td (1 )Tj EMC ET BT 0.196 0.196 0.188 rg /T1_0 1 Tf 0.0447 Tc 8.7 0 0 8.7 317.2402 519.1207 Tm (4.5 )Tj 0.0299 Tc -0.001 -2.647 Td (23.9 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0359 Tc 8.7 0 0 8.7 317.1793 474.0025 Tm (30.6 )Tj EMC ET BT /T1_0 1 Tf 0.0171 Tc 8.7 0 0 8.7 317.2402 429.3715 Tm (4.5 )Tj 0.0003 Tc -0.007 -2.484 Td (3.1 )Tj -0.0155 Tc 9.2 0 0 9.2 317.23 385.69 Tm (2.7 )Tj 0.05 Tc 8.7732 0 0 8.7 317.18 364.09 Tm (3.2 )Tj 0.0106 Tc 8.7 0 0 8.7 317.46 307.93 Tm (19.3 )Tj -0.035 Tc 9.446 0 0 9.8 317.22 285.37 Tm (24.3 )Tj 0.0299 Tc 8.7 0 0 8.7 317.23 263.28 Tm (23.2 )Tj 0.012 Tc 0 -2.647 TD (28)Tj 0.078 0.078 0.071 rg 0 Tc 1.089 0 Td (.)Tj 0.196 0.196 0.188 rg 0.224 0 Td (8 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.4243 0 0 9.2 374.77 673.21 Tm (3.70t )Tj EMC /Suspect <>BDC 9.3475 0 0 9.2 374.82 651.12 Tm (2.10t )Tj EMC ET BT /T1_0 1 Tf -0.005 Tc 8.7 0 0 8.7 375.25 629.53 Tm (6.41 )Tj 0.05 Tc 9.4127 0 0 8.7 374.75 607.44 Tm (5.79t )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.6174 0 0 9.8 374.78 585.85 Tm (0.90" )Tj EMC ET BT /T1_0 1 Tf -0.0031 Tc 9.2 0 0 9.2 374.35 541.21 Tm (2.18 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0465 Tc 9.2 0 0 9.2 374.3132 496.0932 Tm (0.81t )Tj EMC /Suspect <>BDC 0.05 Tc 9.8563 0 0 8.7 374.3 474 Tm (0.92tt )Tj EMC /Suspect <>BDC -0.0204 Tc 9.2 0 0 9.2 374.56 429.37 Tm (10.5 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.0995 0 0 8.7 392.52 429.37 Tm (\(2\)tt )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.029 Tc 8.7 0 0 8.7 374.58 407.76 Tm (10.8 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.4531 0 0 8.7 392.53 407.76 Tm (\(4\)t )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.1317 0 0 9.2 375.04 385.69 Tm (10)Tj 0.078 0.078 0.071 rg 0 Tc 9.2 0 0 9.2 383.81 385.69 Tm (.)Tj 0.196 0.196 0.188 rg 0.167 0 Td (0 )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 11.5717 0 0 11.2 392.43 385.69 Tm (\(l\)t )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0106 Tc 8.7 0 0 8.7 374.58 363.61 Tm (10.5 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.4531 0 0 8.7 392.53 363.61 Tm (\(2\)t )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0025 Tc 8.7 0 0 8.7 374.58 307.93 Tm (1.84" )Tj EMC ET BT /T1_0 1 Tf 0.0401 Tc 9.3 0 0 9.3 374.56 284.89 Tm (1.22t )Tj 0.0272 Tc 0.052 -2.374 Td (1.27t )Tj 0.05 Tc 9.1298 0 0 8.7 374.56 240.25 Tm (1.28t )Tj -0.0065 Tc 9.2 0 0 9.2 432.37 673.68 Tm (3.1 )Tj 0 Tc 8.7 0 0 8.7 489.98 673.21 Tm (3)Tj 0.078 0.078 0.071 rg 0.598 0 Td (.)Tj 0.196 0.196 0.188 rg 0.224 0 Td (8 )Tj -0.0201 Tc 9.8 0 0 9.8 432.34 651.61 Tm (5.2 )Tj -0.0058 Tc 8.7 0 0 8.7 490.45 651.12 Tm (6.5 )Tj /T1_1 1 Tf -0.0295 Tc 8.5 0 0 8.5 432.69 629.53 Tm (1.8 )Tj /T1_0 1 Tf 0.0279 Tc 8.7 0 0 8.7 489.98 629.05 Tm (3.3 )Tj 0.0189 Tc -6.67 -2.429 Td (2.5 )Tj 0.0279 Tc 6.67 -0.055 Td (3.5 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0139 Tc 8.7 0 0 8.7 432.6557 585.3586 Tm (1.9" )Tj EMC ET BT /T1_0 1 Tf -0.0065 Tc 9.2 0 0 9.2 489.49 585.36 Tm (3.5 )Tj 0.029 Tc 8.7 0 0 8.7 432.18 541.21 Tm (12.9 )Tj 0.0106 Tc 6.621 0 Td (19.7 )Tj 0.0087 Tc 9.2 0 0 9.2 431.48 519.12 Tm (4.3 )Tj -0.001 Tc 8.7 0 0 8.7 489.48 519.12 Tm (5.1 )Tj 0.0106 Tc -6.586 -2.647 Td (17.5 )Tj 0.0093 Tc 6.621 0 Td (16)Tj 0.078 0.078 0.071 rg 0 Tc 1.007 0 Td (.)Tj 0.196 0.196 0.188 rg 0.236 0 Td (2 )Tj 0.029 Tc -7.863 -2.483 Td (19.9 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0025 Tc 8.7 0 0 8.7 489.7932 474.0018 Tm (16.8" )Tj EMC ET BT /T1_0 1 Tf 0.0465 Tc 8.7 0 0 8.7 431.4858 429.8406 Tm (2.8 )Tj 0.05 Tc 9.5532 0 0 8.7 489.06 429.37 Tm (2.1t )Tj 0.0465 Tc 8.7 0 0 8.7 431.47 407.76 Tm (2.6 )Tj 0.0189 Tc 6.621 0 Td (2.3 )Tj -6.621 -2.537 Td (2.1 )Tj 0.0038 Tc 9.3 0 0 9.3 489.07 385.69 Tm (2.2 )Tj -0.0278 Tc 9.8 0 0 9.8 431.46 364.09 Tm (2.5 )Tj 0.05 Tc 9.2676 0 0 8.7 489.76 363.61 Tm (1.7t )Tj 0.0106 Tc 8.7 0 0 8.7 432.18 308.41 Tm (13.3 )Tj 0.029 Tc 6.566 0 Td (18.6 )Tj -6.566 -2.648 Td (16.4 )Tj 0 Tc 6.533 -0.055 Td (9)Tj 0.078 0.078 0.071 rg 0.598 0 Td (.)Tj 0.196 0.196 0.188 rg 0.05 Tc 10.9105 0 0 8.7 496.13 284.89 Tm (8t )Tj 0.0093 Tc 8.7 0 0 8.7 432.18 263.28 Tm (17)Tj 0.078 0.078 0.071 rg 0 Tc 1.007 0 Td (.)Tj 0.196 0.196 0.188 rg 0.283 0 Td (5 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0093 Tc 8.7 0 0 8.7 489.7827 263.28 Tm (12)Tj 0.078 0.078 0.071 rg 0 Tc 1.007 0 Td (.)Tj 0.196 0.196 0.188 rg 0.05 Tc 10.2114 0 0 8.7 500.52 263.28 Tm (9' )Tj EMC ET BT /T1_0 1 Tf 0.029 Tc 8.7 0 0 8.7 432.18 240.25 Tm (19.9 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0093 Tc 8.7 0 0 8.7 489.7827 240.25 Tm (16)Tj 0.078 0.078 0.071 rg 0 Tc 1.007 0 Td (.)Tj 0.196 0.196 0.188 rg -0.0036 Tc 0.231 0 Td (0" )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.5469 0 0 8.7 59.96 222.97 Tm (xt )Tj 0.0223 Tc 8.7 0 0 8.7 70.44 222.97 Tm (significant )Tj 0.0341 Tc 4.584 0 Td (change )Tj 0.0283 Tc 3.144 0 Td (after )Tj 0.0246 Tc 2.093 0 Td (salbutamol )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0364 Tc 8.7 0 0 8.7 197.1816 222.97 Tm (\(p<0)Tj 0.078 0.078 0.071 rg 0 Tc 1.977 0 Td (.)Tj 0.196 0.196 0.188 rg 0.0147 Tc 0.231 0 Td (05 )Tj EMC ET BT /T1_0 1 Tf 0.0289 Tc 8.7 0 0 8.7 226.953 222.97 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.7 0 0 8.7 241.83 222.97 Tm (0)Tj 0.078 0.078 0.071 rg 0.541 0 Td (.)Tj 0.196 0.196 0.188 rg 0.0313 Tc 0.231 0 Td (01\), )Tj EMC ET BT /T1_0 1 Tf 0.0499 Tc 8.7 0 0 8.7 264.3804 222.97 Tm (\(\)significant )Tj 0.0434 Tc 5.575 0 Td (order )Tj 0.0151 Tc 2.426 0 Td (effect, )Tj 0.278 0.278 0.271 rg 0.05 Tc 14.3605 0 0 8.7 358.52 222.97 Tm (tt )Tj 0.196 0.196 0.188 rg 0.0451 Tc 8.7 0 0 8.7 368.56 222.97 Tm (change )Tj 0.0283 Tc 3.199 0 Td (after )Tj 0.0361 Tc 2.093 0 Td (salbutamollargcr )Tj 0.016 Tc 7.405 0 Td (than )Tj 0.278 0.278 0.271 rg 0.0263 Tc 1.977 0 Td (forrelated )Tj 0.196 0.196 0.188 rg 0.0215 Tc -50.205 -1.269 Td (comparisons. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.2146 0 0 8.7 110.38 211.93 Tm (VA )Tj EMC ET BT /T1_0 1 Tf 0.0289 Tc 8.7 0 0 8.7 124.23 211.93 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.3158 0 0 8.7 140.14 211.93 Tm (VA': )Tj EMC ET BT /T1_0 1 Tf 0.0308 Tc 8.7 0 0 8.7 157.83 211.93 Tm (alveolar )Tj 0.0307 Tc 3.594 0 Td (volume )Tj 0.0291 Tc 3.366 0 Td (measured )Tj 0.0228 Tc 4.249 0 Td (respectively )Tj 0.05 Tc 8.7659 0 0 8.7 301.93 211.93 Tm (by )Tj 0.0396 Tc 8.7 0 0 8.7 312.94 211.93 Tm (multi )Tj 0.0213 Tc 2.486 0 Td (breath )Tj 0.05 Tc 8.7732 0 0 8.7 359.43 211.93 Tm (and )Tj 0.0354 Tc 8.7 0 0 8.7 374.76 211.93 Tm (single )Tj 0.0324 Tc 2.774 0 Td (breath )Tj 0.0172 Tc 2.866 0 Td (methods. )Tj 0.278 0.278 0.271 rg 0.0121 Tc 10.4 0 0 10.4 56.13 182.65 Tm (then )Tj 0.196 0.196 0.188 rg 0.008 Tc 2.266 0 Td (practicable. )Tj 0.05 Tc 10.4139 0 0 10.4 134.81 182.65 Tm (It )Tj 0.0324 Tc 10.4 0 0 10.4 147.26 182.65 Tm (can )Tj -0.0055 Tc 1.993 0 Td (now )Tj -0.0103 Tc 2.263 0 Td (be )Tj 0.0323 Tc 1.42 0 Td (done )Tj -0.035 Tc 9.4414 0 0 10.4 233.05 182.65 Tm ([8)Tj 0.078 0.078 0.071 rg 0 Tc 10.4 0 0 10.4 240.37 182.65 Tm (] )Tj 0.196 0.196 0.188 rg 0.0355 Tc 0.888 0 Td (but )Tj -0.035 Tc 9.9503 0 0 10.4 269.17 182.65 Tm (few )Tj 0.0133 Tc 10.4 0 0 10.4 56.07 171.61 Tm (laboratories )Tj 0.0034 Tc 5.454 0 Td (have )Tj 0.0143 Tc 2.49 0 Td (the )Tj -0.0151 Tc 1.838 0 Td (facilities. )Tj 0.0163 Tc 4.203 0 Td (The )Tj -0.0193 Tc 2.168 0 Td (difficu)Tj 0.078 0.078 0.071 rg 0 Tc 2.539 0 Td (l)Tj 0.196 0.196 0.188 rg 0.01 Tc 0.283 0 Td (ty )Tj -0.0132 Tc 1.387 0 Td (was )Tj -0.0091 Tc -20.4 -1.062 Td (recognised )Tj -0.0212 Tc 4.894 0 Td (by )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0474 Tc 7.9001 0 0 7.9001 122.8 160.57 Tm (OGILVIE )Tj EMC ET BT /T1_2 1 Tf 0.05 Tc 10.1514 0 0 9.9 162.63 160.57 Tm (et )Tj 0 Tc 9.9 0 0 9.9 176.1 160.57 Tm (al. )Tj /T1_0 1 Tf -0.035 Tc 9.7536 0 0 10.4 192.24 160.57 Tm ([16\) )Tj 0.0456 Tc 10.4 0 0 10.4 213.49 160.57 Tm (and )Tj 0 Tc 2.123 0 Td (a )Tj -0.0004 Tc 1.024 0 Td (modified )Tj -0.0048 Tc -18.323 -1.062 Td (version )Tj 0.05 Tc 10.5727 0 0 10.4 92.06 149.52 Tm (of )Tj 0.0162 Tc 10.4 0 0 10.4 106.53 149.52 Tm (their )Tj 0.021 Tc 2.451 0 Td (procedure )Tj 0.016 Tc 4.65 0 Td (constituted )Tj 0.0143 Tc 5.176 0 Td (the )Tj 0.0284 Tc 1.759 0 Td (present )Tj 0.0107 Tc -18.927 -1.061 Td (method )Tj -0.035 Tc 9.9572 0 0 10.4 91.14 138.49 Tm (2; )Tj -0.0212 Tc 10.4 0 0 10.4 102.73 138.49 Tm (by )Tj -0.0033 Tc 1.381 0 Td (this )Tj 0.02 Tc 1.801 0 Td (method )Tj 0.0106 Tc 3.455 0 Td (gas )Tj 0.0214 Tc 1.716 0 Td (uptake )Tj 0.0152 Tc 3.129 0 Td (during )Tj 0.0116 Tc 3.041 0 Td (sample )Tj -0.0015 Tc -19.103 -1.015 Td (collect)Tj 0.078 0.078 0.071 rg 0 Tc 2.632 0 Td (i)Tj 0.196 0.196 0.188 rg 0.0358 Tc 0.276 0 Td (on )Tj -0.0132 Tc 1.578 0 Td (was )Tj 0.013 Tc 2.021 0 Td (assumed )Tj 0.01 Tc 4.069 0 Td (to )Tj -0.035 Tc 10.1515 0 0 10.4 179.53 127.93 Tm (be )Tj -0.0171 Tc 10.4 0 0 10.4 194.3 127.93 Tm (offset )Tj -0.0212 Tc 2.734 0 Td (by )Tj 0.0373 Tc 1.512 0 Td (an )Tj 0.0306 Tc 1.534 0 Td (uptake )Tj -0.0235 Tc -19.117 -1.062 Td (deficit )Tj 0.0244 Tc 3 0 Td (during )Tj 0.0141 Tc 3.324 0 Td (inspiration. )Tj 0.0394 Tc 5.308 0 Td (The )Tj -0.0081 Tc 2.168 0 Td (deficit )Tj 0.0098 Tc 3.101 0 Td (was )Tj 0.0246 Tc 2.167 0 Td (treated )Tj -0.0053 Tc -19.114 -1.062 Td (differently )Tj 0.0238 Tc 4.386 0 Td (in )Tj 0.0143 Tc 1.021 0 Td (the )Tj 0.0166 Tc 1.479 0 Td (related )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0007 Tc 10.4 0 0 10.4 158.8464 105.8404 Tm (ESP )Tj EMC ET BT /T1_0 1 Tf 0.0134 Tc 10.4 0 0 10.4 179.0432 105.8404 Tm (method. )Tj 0.0239 Tc 3.561 0 Td (Neither )Tj 0.02 Tc 3.362 0 Td (method )Tj 0.0036 Tc -18.785 -1.062 Td (made )Tj 0.0031 Tc 2.438 0 Td (allowance )Tj -0.0157 Tc 4.384 0 Td (for )Tj 0.0037 Tc 1.48 0 Td (increased )Tj 0.0106 Tc 4.062 0 Td (gas )Tj 0.0306 Tc 1.624 0 Td (uptake )Tj 0.0336 Tc 3.037 0 Td (during )Tj -0.0055 Tc 3.041 0 Td (slow )Tj 0.0137 Tc -20.119 -1.014 Td (expiration )Tj 0.0098 Tc 4.662 0 Td (as )Tj 0.0068 Tc 1.393 0 Td (might )Tj 0.0157 Tc 2.9 0 Td (occur )Tj -0.0224 Tc 2.816 0 Td (in )Tj 0.0191 Tc 1.257 0 Td (patients )Tj 0.0095 Tc 3.736 0 Td (with )Tj 0.0056 Tc 2.298 0 Td (airflow )Tj 0.0114 Tc 5.263 9.462 Td (limitation)Tj 0.345 0.345 0.333 rg 0 Tc 4.049 0 Td (. )Tj 0.196 0.196 0.188 rg 0.0163 Tc 1.028 0 Td (The )Tj 0.0337 Tc 2.404 0 Td (Morgan )Tj 0.0194 Tc 4.156 0 Td (transfer )Tj 0.0157 Tc 4.015 0 Td (test )Tj 0.0306 Tc 2.208 0 Td (apparatus )Tj 0.0174 Tc -17.863 -1.062 Td (\(method )Tj -0.0331 Tc 3.7 0 Td (4\) )Tj -0.0132 Tc 1.111 0 Td (was )Tj 0.0054 Tc 1.792 0 Td (included )Tj -0.0022 Tc 3.794 0 Td (because )Tj 0.078 0.078 0.071 rg 0 Tc 3.406 0 Td (i)Tj 0.196 0.196 0.188 rg 0.283 0 Td (t )Tj 0.0343 Tc 0.555 0 Td (made )Tj 0.0373 Tc 2.53 0 Td (an )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0124 Tc 10.4 0 0 10.4 500.0912 171.61 Tm (approxi\255)Tj EMC ET BT /T1_0 1 Tf 0.0164 Tc 10.4 0 0 10.4 308.18 160.5652 Tm (mate )Tj 0.0088 Tc 2.207 0 Td (allowance )Tj -0.0224 Tc 4.34 0 Td (in )Tj 0.0112 Tc 1.021 0 Td (terms )Tj 0.05 Tc 11.1292 0 0 10.4 412.69 160.57 Tm (of )Tj 0.0116 Tc 10.4 0 0 10.4 423.69 160.57 Tm (sample )Tj 0.0059 Tc 3.105 0 Td (volume, )Tj 0.0022 Tc 3.509 0 Td (which )Tj -0.0132 Tc 2.677 0 Td (was )Tj 0.0126 Tc -20.46 -1.015 Td (simpler )Tj 0.05 Tc 10.4772 0 0 10.4 344.13 150.01 Tm (to )Tj 0.0131 Tc 10.4 0 0 10.4 357.49 150.01 Tm (apply )Tj 0.0428 Tc 2.731 0 Td (than )Tj 0.0041 Tc 2.347 0 Td (one )Tj -0.001 Tc 1.949 0 Td (based )Tj 0.05 Tc 10.7226 0 0 10.4 459.26 150.01 Tm (on )Tj -0.0093 Tc 10.4 0 0 10.4 475.17 150.01 Tm (time. )Tj 0.0027 Tc 2.477 0 Td (Subjects )Tj 0.0095 Tc -18.583 -1.062 Td (with )Tj 0.0027 Tc 2.162 0 Td (labile )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0021 Tc 10.4 0 0 10.4 357.0156 138.9652 Tm (airflow )Tj EMC ET BT /T1_0 1 Tf 0.0165 Tc 10.4 0 0 10.4 390.6388 138.9652 Tm (limitation )Tj -0.0147 Tc 4.392 0 Td (were )Tj -0.0073 Tc 2.248 0 Td (selected )Tj 0.0074 Tc 3.557 0 Td (for )Tj 0.0187 Tc 1.566 0 Td (study )Tj 0.05 Tc 10.4714 0 0 10.4 307.57 127.93 Tm (as )Tj 0.0012 Tc 10.4 0 0 10.4 319.21 127.93 Tm (being )Tj 0.278 0.278 0.271 rg -0.0179 Tc 2.483 0 Td (likely )Tj 0.196 0.196 0.188 rg 0.05 Tc 10.4772 0 0 10.4 370.53 127.93 Tm (to )Tj -0.0029 Tc 10.4 0 0 10.4 381.93 127.93 Tm (show )Tj 0.05 Tc 10.5203 0 0 10.4 406.56 127.93 Tm (up )Tj 0.0456 Tc 10.4 0 0 10.4 419.89 127.93 Tm (any )Tj -0.009 Tc 1.755 0 Td (differences )Tj 0.0008 Tc 4.58 0 Td (between )Tj 0.0143 Tc 3.596 0 Td (the )Tj 0.0021 Tc -20.676 -1.062 Td (methods. )Tj 0.0394 Tc 3.963 0 Td (The )Tj -0.0021 Tc 1.89 0 Td (airflow )Tj 0.0114 Tc 3.14 0 Td (limitation )Tj 0.0098 Tc 4.254 0 Td (was )Tj 0.05 Tc 10.4772 0 0 10.4 465.09 116.89 Tm (to )Tj -0.0103 Tc 10.4 0 0 10.4 477.13 116.89 Tm (be )Tj 0.0038 Tc 1.198 0 Td (reduced )Tj -0.0212 Tc 3.51 0 Td (by )Tj 0.0217 Tc -20.954 -1.062 Td (bronchodilatation )Tj 0.0098 Tc (as )Tj 0.0121 Tc 8.811 0 Td (this )Tj 0 Tc 1.755 0 Td (m)Tj 0.078 0.078 0.071 rg (i)Tj 0.196 0.196 0.188 rg 0.0194 Tc 1.062 0 Td (rrored )Tj 0.0143 Tc 2.86 0 Td (the )Tj 0.0053 Tc 1.574 0 Td (progression )Tj 0.05 Tc 11.1292 0 0 10.4 527.41 105.84 Tm (of )Tj -0.0022 Tc 10.4 0 0 10.4 307.58 94.8 Tm (disease)Tj 0.078 0.078 0.071 rg 0 Tc 2.896 0 Td (. )Tj 0.196 0.196 0.188 rg 0.0164 Tc 0.755 0 Td (Bronchodilators )Tj 0.0034 Tc 7.112 0 Td (have )Tj 0 Tc 2.344 0 Td (a)Tj 0.078 0.078 0.071 rg 0.51 0 Td (l)Tj 0.196 0.196 0.188 rg -0.033 Tc 0.271 0 Td (so )Tj -0.0101 Tc 1.4 0 Td (been )Tj 0.0203 Tc 2.261 0 Td (used )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.002 Tc 10.4 0 0 10.4 514.4672 94.8 Tm (clini\255)Tj EMC ET BT /T1_0 1 Tf -0.0069 Tc 10.4 0 0 10.4 307.5904 84.2544 Tm (cally )Tj 0.01 Tc 2.545 0 Td (to )Tj 0.0216 Tc 1.47 0 Td (obtain )Tj 0.0038 Tc 3.286 0 Td (results )Tj 0.0238 Tc 3.223 0 Td (in )Tj 0.0086 Tc 1.44 0 Td (breathless )Tj 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137.58 699.61 Tm (I )Tj EMC ET BT /T1_2 1 Tf 0.0271 Tc 10 0 0 10 242.67 699.61 Tm (Breath-holding )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0 Tc 10 0 0 10 335.05 699.61 Tm (\\ )Tj EMC /Suspect <>BDC /T1_4 1 Tf 0.05 Tc 12.9263 0 0 11.4 129.86 680.89 Tm (II )Tj EMC /Suspect <>BDC /C0_0 1 Tf 0 Tc 9.12 0 0 15.36 342.24 680.89 Tm <007E0020>Tj EMC /Suspect <>BDC /T1_4 1 Tf 11.7 0 0 11.7 126.21 671.76 Tm (1 )Tj EMC ET BT /T1_2 1 Tf -0.0165 Tc 10 0 0 10 367.59 671.76 Tm (sample )Tj 0.0453 Tc 3.454 0 Td (collection )Tj ET BT /Suspect <>BDC /T1_4 1 Tf 0 Tc 10.1 0 0 10.1 123.19 654.48 Tm (I )Tj EMC /Suspect <>BDC 11.4 0 0 11.4 119.33 642 Tm (I )Tj EMC /Suspect <>BDC 11.1 0 0 11.1 115.97 631.44 Tm (I )Tj EMC /Suspect <>BDC 11.4 0 0 11.4 112.61 620.41 Tm (I )Tj EMC /Suspect <>BDC -0.035 Tc 5.2571 0 0 11.8 109.21 613.68 Tm (1. )Tj EMC ET BT /T1_2 1 Tf 0.0252 Tc 10 0 0 10 319.97 613.68 Tm (before )Tj -0.0124 Tc 3.274 0 Td (salb)Tj 0.098 0.102 0.09 rg 0 Tc 1.814 0 Td (u)Tj 0.208 0.212 0.2 rg 0.05 Tc 10.0131 0 0 10 376.27 613.68 Tm (tamol )Tj ET BT /Suspect <>BDC /T1_4 1 Tf -0.035 Tc 7.5422 0 0 11.7 105.48 597.85 Tm (I. )Tj EMC ET BT /T1_2 1 Tf 0.0461 Tc 10 0 0 10 319.58 597.85 Tm (after )Tj -0.035 Tc 8.6375 0 0 10 344.57 597.85 Tm (sa)Tj 0.098 0.102 0.09 rg 0 Tc 10 0 0 10 354.05 597.85 Tm (l)Tj 0.208 0.212 0.2 rg 0.0446 Tc 0.24 0 Td (butamol )Tj ET BT /Suspect <>BDC /T1_5 1 Tf 0 Tc 13.2 0 0 13.2 102.17 586.33 Tm (h )Tj EMC /Suspect <>BDC /C0_0 1 Tf 5.76 0 0 9.12 84.96 555.12 Tm <0030>Tj 0.098 0.102 0.09 rg 8.64 0 0 9.12 93.13 555.12 Tm <007E002D002D002D002D>Tj 0.208 0.212 0.2 rg 11.52 0 0 9.12 136.33 555.12 Tm <007E002D002D007E007E>Tj 0.098 0.102 0.09 rg 9.6 0 0 9.12 193.93 555.12 Tm <002D002D007E>Tj 0.208 0.212 0.2 rg 8.64 0 0 9.12 222.73 555.12 Tm <007E002D002D002D002D007E002D002D002D002D>Tj 0.098 0.102 0.09 rg 14.4 0 0 9.12 309.13 555.12 Tm <007E>Tj 0.208 0.212 0.2 rg 11.4 0 0 9.12 323.52 555.12 Tm <007E002D002D007E007E002D002D007E0020>Tj EMC ET BT /T1_2 1 Tf 10.4 0 0 10.4 138.63 549.85 Tm (2 )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 8.6 0 0 8.6 223.88 546 Tm (1 )Tj EMC ET BT /T1_2 1 Tf 10.4 0 0 10.4 230.77 549.85 Tm [(6 )-3273(8 )]TJ ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 10.1885 0 0 10.4 319.35 549.85 Tm (10 )Tj EMC ET BT 0.098 0.102 0.09 rg /T1_2 1 Tf 0 Tc 10.4 0 0 10.4 363.99 549.85 Tm (1)Tj 0.208 0.212 0.2 rg 0.485 0 Td (2 )Tj 0.098 0.102 0.09 rg 3.854 0 Td (1)Tj 0.208 0.212 0.2 rg 0.444 0 Td (4 )Tj /T1_3 1 Tf 0.05 Tc 9.72 0 0 9.5 425.7 549.85 Tm (Time )Tj -0.035 Tc 9.3717 0 0 9.5 452.98 549.85 Tm (\(s\) )Tj 0.0359 Tc 9.5 0 0 9.5 370.36 535.92 Tm (Method )Tj ET BT /Suspect <>BDC 0.098 0.102 0.09 rg /T1_3 1 Tf -0.035 Tc 6.4035 0 0 8.8 107.01 524.41 Tm (J-)Tj 0.208 0.212 0.2 rg 0 Tc 8.8 0 0 8.8 110.74 524.41 Tm (-)Tj 0.098 0.102 0.09 rg 0.164 0 Td (-)Tj 0.208 0.212 0.2 rg 0.05 Tc 13.0829 0 0 8.8 114.5 524.41 Tm (--)Tj 0.098 0.102 0.09 rg 0 Tc 8.8 0 0 8.8 117.94 524.41 Tm (-)Tj EMC /Suspect <>BDC 0.208 0.212 0.2 rg /T1_2 1 Tf 0.05 Tc 9.2066 0 0 8.8 122.32 524.41 Tm (--\267-)Tj 0.098 0.102 0.09 rg 0 Tc 8.8 0 0 8.8 130.96 524.41 Tm (-)Tj EMC /Suspect <>BDC 0.208 0.212 0.2 rg /T1_0 1 Tf -0.035 Tc 9.6201 0 0 12.8 135.25 524.41 Tm (--------)Tj 0.098 0.102 0.09 rg 0 Tc 12.8 0 0 12.8 154.89 524.41 Tm (-)Tj 0.275 0.278 0.267 rg -0.035 Tc 6.9065 0 0 12.8 158.32 524.41 Tm (---1-)Tj EMC /Suspect <>BDC 0.098 0.102 0.09 rg /C0_0 1 Tf 0 Tc 5.76 0 0 7.68 169.93 524.41 Tm <002D002B002D002D>Tj 0.208 0.212 0.2 rg 5.4569 0 0 7.68 192.97 524.41 Tm <002D002D002D00740066002D002D002D0021002D002D002E003B005F005F002D002D002D002D>Tj 0.098 0.102 0.09 rg 3.2229 0 0 7.68 296.65 524.41 Tm <002D002D003D002D003A002E002E003A002E002E002E003A002E002E002E003A002E002E003A007E002D>Tj EMC ET BT 0.208 0.212 0.2 rg /T1_2 1 Tf 0.0431 Tc 10 0 0 10 369.52 524.41 Tm (JM )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0464 Tc 10.4 0 0 10.4 369.5 513.85 Tm (Og )Tj EMC /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 9.1521 0 0 10.4 370.35 502.81 Tm (ESP )Tj EMC /Suspect <>BDC 0.098 0.102 0.09 rg /C0_0 1 Tf 0 Tc 12 0 0 10.08 116.64 489.37 Tm <002D>Tj 0.208 0.212 0.2 rg 12.48 0 0 10.08 128.65 489.37 Tm <002D002D002D>Tj 0.098 0.102 0.09 rg 6.24 0 0 10.08 166.09 489.37 Tm <002D00480021002D002D002D>Tj 0.208 0.212 0.2 rg 9.12 0 0 10.08 203.53 489.37 Tm <002D002D0031002D002D0027002D002D002D002D002D002D002D002D002D002D002D007E0020>Tj EMC ET BT /T1_2 1 Tf 0.0126 Tc 10 0 0 10 369.86 489.37 Tm (Morgan )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0 Tc 9.1 0 0 9.1 223.43 481.21 Tm (I )Tj EMC /Suspect <>BDC 10.4 0 0 10.4 222.91 470.65 Tm (I )Tj EMC ET BT 0.098 0.102 0.09 rg /T1_2 1 Tf 10 0 0 10 416.1 496.56 Tm (} )Tj 1.663 1.968 Td (E)Tj 0.208 0.212 0.2 rg 0.0405 Tc 0.693 0 Td (ffective )Tj 0.0252 Tc 3.775 0 Td (breath )Tj 0.0461 Tc -4.464 -1.152 Td (holdi)Tj 0.098 0.102 0.09 rg 0 Tc 2.352 0 Td (n)Tj 0.208 0.212 0.2 rg 0.586 0 Td (g )Tj 0.05 Tc 10.4012 0 0 10 470.35 504.72 Tm (time )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 11.7083 0 0 16.3 221.22 458.65 Tm (+--)Tj 0.349 0.353 0.341 rg 0.05 Tc 42.4692 0 0 16.3 237.09 458.65 Tm (----)Tj EMC ET BT 0.412 0.416 0.4 rg /T1_0 1 Tf 0 Tc 16.3 0 0 16.3 304.13 458.65 Tm [(-)-698(-)]TJ 0.05 Tc 40.9249 0 0 16.3 338.39 458.65 Tm (--)Tj 0 Tc 16.3 0 0 16.3 371.81 458.65 Tm (-)Tj 0.275 0.278 0.267 rg 1.06 0 Td (-)Tj 0.208 0.212 0.2 rg 1.606 0 Td (} )Tj 0.098 0.102 0.09 rg /T1_2 1 Tf 10 0 0 10 432.25 458.65 Tm (E)Tj 0.208 0.212 0.2 rg 0.0257 Tc 0.686 0 Td (stimated )Tj 0.0026 Tc -0.682 -1.2 Td (residual )Tj 0.0192 Tc 3.856 0 Td (volume )Tj /T1_0 1 Tf 0 Tc 11.1 0 0 11.1 84.41 465.84 Tm (2 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 11.6691 0 0 14.6 220.42 440.89 Tm (!._ )Tj EMC ET BT 0.275 0.278 0.267 rg /T1_0 1 Tf 0.05 Tc 27.9873 0 0 14.6 236.71 440.89 Tm (_________ )Tj 0.349 0.353 0.341 rg 0 Tc 14.6 0 0 14.6 378.28 440.89 Tm (_ )Tj 0.208 0.212 0.2 rg /T1_2 1 Tf 10 0 0 10 414.66 424.09 Tm (} )Tj 0.0037 Tc 1.759 0 Td (Residual )Tj 0.0288 Tc 4.244 0 Td (volume )Tj /T1_0 1 Tf 0 Tc 11.2 0 0 11.2 84.35 419.28 Tm (3 )Tj 13 0 0 13 165.09 409.21 Tm (V)Tj 0.349 0.353 0.341 rg 1.025 0 Td (' )Tj 0.208 0.212 0.2 rg /T1_2 1 Tf 7.5001 0 0 7.5001 172.33 404.41 Tm (A )Tj /T1_0 1 Tf -0.0077 Tc 8.4 0 0 8.4 45.08 390 Tm (Fig. )Tj /T1_2 1 Tf 0.0342 Tc 8.1 0 0 8.1 61.7 390 Tm (I. )Tj /T1_0 1 Tf 0.0317 Tc 8.4 0 0 8.4 74.33 390 Tm (The )Tj 0.0043 Tc 2.006 0 Td (mean )Tj 0.0025 Tc 2.63 0 Td (relationship )Tj 0.275 0.278 0.267 rg 0.05 Tc 8.9033 0 0 8.4 156.4 390 Tm (of )Tj 0.208 0.212 0.2 rg 0.0075 Tc 8.4 0 0 8.4 166.48 390 Tm (alveolar )Tj -0.004 Tc 3.664 0 Td (volume )Tj 0.0253 Tc 3.371 0 Td (to )Tj -0.0001 Tc 1.257 0 Td (time )Tj 0.0169 Tc 2.107 0 Td (during )Tj 0.275 0.278 0.267 rg 0.0197 Tc 3.093 0 Td (the )Tj 0.208 0.212 0.2 rg 0.0089 Tc 1.661 0 Td (procedure )Tj 0.0074 Tc 4.445 0 Td (for )Tj 0.0108 Tc 1.551 0 Td (measurement )Tj 0.05 Tc 9.4598 0 0 8.4 393.03 390 Tm (of )Tj 0.0135 Tc 8.4 0 0 8.4 403.66 390 Tm (transfer )Tj 0.0146 Tc 3.477 0 Td (factor. )Tj 0.0317 Tc 3.088 0 Td (The )Tj 0.0233 Tc 2.006 0 Td (mean )Tj -0.0126 Tc 2.563 0 Td (effective )Tj 0.0097 Tc -53.817 -1.085 Td (breathholding )Tj 0.0027 Tc 5.996 0 Td (times )Tj 0.0074 Tc 2.506 0 Td (for )Tj 0.0078 Tc 1.551 0 Td (methods )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.4 0 0 8.4 162.6472 380.886 Tm (I )Tj EMC ET BT /T1_0 1 Tf 0.0073 Tc 8.4 0 0 8.4 168.3676 380.886 Tm (\(Jones )Tj 0.0269 Tc 2.917 0 Td (and )Tj -0.0056 Tc 1.948 0 Td (Meade\), )Tj 0 Tc 3.656 0 Td (2 )Tj 0.275 0.278 0.267 rg -0.0135 Tc 0.794 0 Td (\(Ogilvie\), )Tj 0.208 0.212 0.2 rg 0 Tc 4.171 0 Td (3 )Tj ET BT /Suspect <>BDC 0.275 0.278 0.267 rg /T1_0 1 Tf -0.0066 Tc 8.4 0 0 8.4 288.37 380.886 Tm (\(ESP\) )Tj EMC ET BT /T1_0 1 Tf 0.0269 Tc 8.4 0 0 8.4 311.428 380.886 Tm (and )Tj 0.208 0.212 0.2 rg 0 Tc 1.835 0 Td (4 )Tj 0.0187 Tc 0.849 0 Td (\(Morgan\) )Tj 0.0246 Tc 4.288 0 Td (are )Tj 0.0007 Tc 1.657 0 Td (also )Tj 0.0043 Tc 1.938 0 Td (shown. )Tj 0.023 Tc 3.261 0 Td (Conditions )Tj 0.0058 Tc 4.926 0 Td (before )Tj 0.05 Tc 8.4599 0 0 8.4 493.35 380.89 Tm (and )Tj 0.0312 Tc 8.4 0 0 8.4 509.2 380.89 Tm (after )Tj 0.011 Tc -55.319 -1.087 Td (salbutamol )Tj 0.0246 Tc 4.805 0 Td (are )Tj 0.0025 Tc 1.608 0 Td (represented )Tj -0.0126 Tc 4.971 0 Td (respectively )Tj 0.05 Tc 7.8432 0 0 7.6 182.41 371.76 Tm (by )Tj 0.275 0.278 0.267 rg 0.0228 Tc 8.4 0 0 8.4 192.88 371.76 Tm (continuous )Tj 0.05 Tc 8.4599 0 0 8.4 233.67 371.76 Tm (and )Tj 0.208 0.212 0.2 rg 0.0205 Tc 8.4 0 0 8.4 249.53 371.76 Tm (interrupted )Tj -0.0242 Tc 4.914 0 Td (lines. )Tj -0.0019 Tc 10.4 0 0 10.4 44.53 348.25 Tm (example, )Tj -0.0099 Tc 4.023 0 Td (two )Tj 0.05 Tc 11.1292 0 0 10.4 105.49 348.25 Tm (of )Tj -0.0088 Tc 10.4 0 0 10.4 118.53 348.25 Tm (the )Tj 0.013 Tc 1.574 0 Td (present )Tj -0.0034 Tc 3.307 0 Td (subjects. )Tj 0.0394 Tc 3.837 0 Td (The )Tj 0.0306 Tc 1.983 0 Td (apparatus )Tj 0.0225 Tc -17.815 -1.062 Td (and )Tj 0.0062 Tc 1.812 0 Td (procedures )Tj 0.0152 Tc 4.65 0 Td (conformed )Tj 0.275 0.278 0.267 rg 0.01 Tc 4.761 0 Td (to )Tj 0.208 0.212 0.2 rg -0.0088 Tc 1.108 0 Td (the )Tj -0.0015 Tc 1.465 0 Td (specifications )Tj 0.05 Tc 11.1292 0 0 10.4 247.57 337.21 Tm (of )Tj 0.0143 Tc 10.4 0 0 10.4 259.17 337.21 Tm (the )Tj 0.275 0.278 0.267 rg 0.0176 Tc -20.642 -1.062 Td (standardization )Tj 0.208 0.212 0.2 rg 0.0069 Tc 6.706 0 Td (working )Tj 0.0313 Tc 3.649 0 Td (party )Tj 0.05 Tc 10.5727 0 0 10.4 178.46 326.16 Tm (of )Tj 0.0143 Tc 10.4 0 0 10.4 190.53 326.16 Tm (the )Tj 0.0351 Tc 1.52 0 Td (European )Tj 0.0247 Tc 4.38 0 Td (Coal )Tj 0.0225 Tc -19.938 -1.062 Td (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0173 Tc 10.4 0 0 10.4 64.1388 315.1152 Tm (Steel )Tj EMC ET BT /T1_0 1 Tf 0.0233 Tc 10.4 0 0 10.4 88.2148 315.1152 Tm (Community )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.9277 0 0 10.4 143.28 315.12 Tm ([20]. )Tj EMC ET BT /T1_0 1 Tf 0.0163 Tc 10.4 0 0 10.4 165.51 315.12 Tm (The )Tj 0.0062 Tc 1.983 0 Td (experimental )Tj -0.0031 Tc 5.678 0 Td (design )Tj 0.0087 Tc -19.339 -1.061 Td (enabled )Tj 0.0138 Tc 3.509 0 Td (comparisons )Tj 0.05 Tc 10.4772 0 0 10.4 138.21 304.09 Tm (to )Tj -0.0103 Tc 10.4 0 0 10.4 150.73 304.09 Tm (be )Tj 0.0036 Tc 1.289 0 Td (made )Tj 0.0072 Tc 2.539 0 Td (within )Tj 0.0208 Tc 2.956 0 Td (breaths )Tj 0.0225 Tc 3.358 0 Td (and )Tj 0.0072 Tc -20.39 -1.062 Td (within )Tj 0.275 0.278 0.267 rg -0.0012 Tc 3.033 0 Td (subjects )Tj 0.208 0.212 0.2 rg 0.042 Tc 3.66 0 Td (rather )Tj 0.0274 Tc 2.998 0 Td (than )Tj -0.0069 Tc 2.312 0 Td (between )Tj 0.0054 Tc 3.769 0 Td (subjects )Tj 0.0024 Tc 3.706 0 Td (where )Tj -0.0088 Tc -19.433 -1.015 Td (the )Tj 0.275 0.278 0.267 rg 0.0096 Tc 1.558 0 Td (spread )Tj 0.208 0.212 0.2 rg 0.05 Tc 11.1292 0 0 10.4 92.05 282.49 Tm (of )Tj -0.0038 Tc 10.4 0 0 10.4 104.15 282.49 Tm (results )Tj -0.0132 Tc 2.954 0 Td (was )Tj 0 Tc 1.846 0 Td (w)Tj 0.098 0.102 0.09 rg 0.685 0 Td (i)Tj 0.208 0.212 0.2 rg 0.002 Tc 0.276 0 Td (der. )Tj -0.0039 Tc -10.564 -1.062 Td (Before )Tj 0.275 0.278 0.267 rg 0.0184 Tc 3.129 0 Td (salbutamol )Tj 0.208 0.212 0.2 rg 0.0133 Tc 5.043 0 Td (methods )Tj 0 Tc 4.029 0 Td (1 )Tj 0.0456 Tc 0.855 0 Td (and )Tj 0 Tc 2.036 0 Td (2 )Tj -0.0084 Tc 0.966 0 Td (gave )Tj -0.0001 Tc 2.362 0 Td (nearly )Tj -0.0007 Tc -19.392 -1.061 Td (identical )Tj 0.0038 Tc 3.838 0 Td (results )Tj 0.0074 Tc 2.989 0 Td (for )Tj 0.05 Tc 10.471 0 0 10.4 131.95 260.41 Tm (Kco, )Tj 10.8137 0 0 10.4 157.35 260.41 Tm (TI )Tj 0.0456 Tc 10.4 0 0 10.4 171.73 260.41 Tm (and )Tj 0.0465 Tc 1.894 0 Td (TI'; )Tj -0.0033 Tc 1.944 0 Td (this )Tj 0.275 0.278 0.267 rg 0.0009 Tc 1.835 0 Td (suggested )Tj 0.208 0.212 0.2 rg 0.0402 Tc -17.942 -1.062 Td (that )Tj -0.0088 Tc 2.031 0 Td (the )Tj -0.007 Tc 1.57 0 Td (modified )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.011 Tc 10.4 0 0 10.4 122.2988 249.3652 Tm (Ogilvie )Tj EMC ET BT /T1_0 1 Tf 0.02 Tc 10.4 0 0 10.4 156.4628 249.3652 Tm (method )Tj -0.0188 Tc 3.453 0 Td (effectively )Tj -0.0021 Tc 4.477 0 Td (allowed )Tj 0.0074 Tc -18.739 -1.062 Td (for )Tj -0.0098 Tc 1.893 0 Td (airflow )Tj 0.0083 Tc 3.556 0 Td (limitation. )Tj 0.0394 Tc 4.938 0 Td (The )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0007 Tc 10.4 0 0 10.4 176.5868 238.3204 Tm (ESP )Tj EMC ET BT /T1_0 1 Tf 0.02 Tc 10.4 0 0 10.4 201.5884 238.3204 Tm (method )Tj -0.0125 Tc 3.878 0 Td (yielded )Tj -0.0063 Tc -19.075 -1.016 Td (significantly )Tj 0.0071 Tc 5.229 0 Td (higher )Tj -0.0033 Tc 2.862 0 Td [(results; )-119(this )]TJ -0.0132 Tc 4.938 0 Td (was )Tj 0.0215 Tc 1.837 0 Td (due )Tj 0.01 Tc 1.807 0 Td (to )Tj -0.0019 Tc 1.102 0 Td (its )Tj 0.0263 Tc 1.24 0 Td (shorter )Tj 0.0088 Tc -19.012 -1.061 Td (estimated )Tj 0.0191 Tc 4.581 0 Td (breathholding )Tj 0.0094 Tc 6.412 0 Td (time )Tj 0.0204 Tc 2.439 0 Td (compared )Tj 0.0095 Tc 4.763 0 Td (with )Tj 0.0143 Tc 2.49 0 Td (the )Tj 0.0342 Tc -20.684 -1.062 Td (other )Tj 0.0133 Tc 2.869 0 Td (methods )Tj -0.035 Tc 9.82 0 0 10.4 116.4 205.69 Tm ([5, )Tj 9.7157 0 0 10.4 133.81 205.69 Tm (9\). )Tj 0.05 Tc 10.5034 0 0 10.4 151.13 205.69 Tm (In )Tj 0.0143 Tc 10.4 0 0 10.4 167.97 205.69 Tm (the )Tj 0.013 Tc 1.943 0 Td (present )Tj 0.0187 Tc 3.63 0 Td (study )Tj -0.0033 Tc 2.965 0 Td (this )Tj 0.0092 Tc -20.499 -1.062 Td (disadvantage )Tj 0.0098 Tc 5.87 0 Td (was )Tj 0.05 Tc 10.4827 0 0 10.4 126.71 194.65 Tm (not )Tj -0.0078 Tc 10.4 0 0 10.4 146.3 194.65 Tm (offset )Tj -0.0212 Tc 2.78 0 Td (by )Tj -0.0006 Tc 1.558 0 Td (any )Tj 0.275 0.278 0.267 rg 0.0176 Tc 1.986 0 Td (compensating )Tj 0.208 0.212 0.2 rg 0.0077 Tc -16.201 -1.062 Td (advantages, )Tj -0.033 Tc 5.304 0 Td (so )Tj 0.0093 Tc 1.396 0 Td (there )Tj -0.0037 Tc 2.533 0 Td (is )Tj 0 Tc 1.152 0 Td (a )Tj 0.0032 Tc 0.924 0 Td (case )Tj 0.0074 Tc 2.213 0 Td (for )Tj 0.275 0.278 0.267 rg 0.0318 Tc 1.709 0 Td (abandoning )Tj 0.208 0.212 0.2 rg 0.0143 Tc 5.454 0 Td (the )Tj 0.02 Tc -20.722 -1.015 Td (method )Tj 0.0456 Tc 3.407 0 Td (and )Tj 0.005 Tc 1.902 0 Td (recalculating )Tj 0.0038 Tc 5.538 0 Td (results )Tj -0.001 Tc 2.956 0 Td (based )Tj 0.0358 Tc 2.62 0 Td (on )Tj 0.05 Tc 10.615 0 0 10.4 227.91 173.05 Tm (it )Tj 10.9123 0 0 10.5 237.34 173.05 Tm ([II, )Tj -0.035 Tc 9.555 0 0 10.4 256.95 173.05 Tm (18]. )Tj 0.0183 Tc 10.4 0 0 10.4 53.69 162.01 Tm (Inhalation )Tj 0.05 Tc 11.6856 0 0 10.4 105.01 162.01 Tm (of )Tj 0.0184 Tc 10.4 0 0 10.4 121.77 162.01 Tm (salbutamol )Tj 0.0122 Tc 5.266 0 Td (did )Tj 0.0324 Tc 2.086 0 Td (not )Tj -0.0063 Tc 2.11 0 Td (significantly )Tj 0.0105 Tc -17.026 -1.062 Td (change )Tj -0.0088 Tc 3.191 0 Td (the )Tj 0.0194 Tc 1.569 0 Td (transfer )Tj 0.0196 Tc 3.499 0 Td (factor )Tj 0.0456 Tc 2.724 0 Td (and )Tj 0.05 Tc 10.8915 0 0 10.4 176.59 150.97 Tm (Kco )Tj -0.035 Tc 10.0482 0 0 10.4 199.69 150.97 Tm (by )Tj 0.02 Tc 10.4 0 0 10.4 213.1 150.97 Tm (method )Tj 0 Tc 3.547 0 Td (l )Tj 0.05 Tc 10.531 0 0 10.4 257.29 150.97 Tm (but )Tj 0.275 0.278 0.267 rg 0.0038 Tc 10.4 0 0 10.4 43.19 139.93 Tm (results )Tj 0.208 0.212 0.2 rg -0.0212 Tc 3.14 0 Td (by )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0084 Tc 10.4 0 0 10.4 91.082 139.93 Tm (all )Tj EMC ET BT /T1_0 1 Tf 0.0143 Tc 10.4 0 0 10.4 107.0044 139.93 Tm (the )Tj 0.0342 Tc 1.747 0 Td (other )Tj 0.0133 Tc 2.731 0 Td (methods )Tj -0.0147 Tc 3.97 0 Td (were )Tj -0.0024 Tc 2.387 0 Td (significantly )Tj -0.0039 Tc -16.925 -1.062 Td (reduced)Tj 0.098 0.102 0.09 rg 0 Tc 3.164 0 Td (. )Tj 0.208 0.212 0.2 rg 0.0394 Tc 0.612 0 Td (The )Tj -0.0078 Tc 1.984 0 Td (difference )Tj 0.0154 Tc 4.338 0 Td (could )Tj 0.0324 Tc 2.732 0 Td (not )Tj 0.0188 Tc 1.708 0 Td (have )Tj 0.0053 Tc 2.31 0 Td (been )Tj 0.0445 Tc 2.297 0 Td (due )Tj 0.01 Tc 1.945 0 Td (to )Tj 0.0011 Tc -21.15 -1.062 Td (systematic )Tj 0.0055 Tc 4.482 0 Td (changes )Tj 0.05 Tc 10.6555 0 0 10.4 126.63 117.84 Tm (in )Tj 0.0233 Tc 10.4 0 0 10.4 138.14 117.84 Tm (carbon )Tj 0.0099 Tc 3.146 0 Td (monoxide )Tj 0.0053 Tc 4.434 0 Td (back )Tj 0.0117 Tc 2.258 0 Td (tension )Tj 0.05 Tc 10.5727 0 0 10.4 43.1 107.28 Tm (or )Tj 0.0076 Tc 10.4 0 0 10.4 57.5 107.28 Tm (cardiac )Tj 0.0471 Tc 3.415 0 Td (output )Tj 0.0244 Tc 3.277 0 Td (during )Tj 0.0143 Tc 3.284 0 Td (the )Tj 0.0003 Tc 1.754 0 Td (test )Tj 0.0152 Tc 1.943 0 Td (procedure )Tj 0.05 Tc 11.1292 0 0 10.4 247.57 107.28 Tm (or )Tj 10.4772 0 0 10.4 262.53 107.28 Tm (to )Tj 0.0226 Tc 10.4 0 0 10.4 43.1 96.25 Tm (other )Tj -0.0248 Tc 2.768 0 Td (effects )Tj 0.05 Tc 11.6856 0 0 10.4 104.53 96.25 Tm (of )Tj 0.275 0.278 0.267 rg 0.0235 Tc 10.4 0 0 10.4 119.85 96.25 Tm (salbutamol )Tj 0.208 0.212 0.2 rg 0.0098 Tc 5.265 0 Td (as )Tj -0.0047 Tc 1.485 0 Td (these )Tj 0.011 Tc 2.679 0 Td (would )Tj 0.0188 Tc 3.185 0 Td (have )Tj -0.0159 Tc -19.994 -1.062 Td (affected )Tj -0.0314 Tc 3.6 0 Td (all )Tj 0.021 Tc 1.439 0 Td (methods )Tj 0.0021 Tc 3.961 0 Td (equally. )Tj 0.0216 Tc 3.696 0 Td (Instead )Tj 0.0143 Tc 3.512 0 Td (the )Tj -0.0026 Tc 1.701 0 Td (difference )Tj -0.0132 Tc 6.47 25.293 Td (was )Tj -0.0016 Tc 1.884 0 Td (due )Tj 0.05 Tc 10.4772 0 0 10.4 335.01 348.25 Tm (to )Tj 0.275 0.278 0.267 rg 0.0143 Tc 10.4 0 0 10.4 347.97 348.25 Tm (the )Tj 0.208 0.212 0.2 rg 0.0235 Tc 1.604 0 Td (salbutamol )Tj 0.0083 Tc 4.952 0 Td (reducing )Tj -0.0024 Tc 3.863 0 Td (significantly )Tj 0.0143 Tc 5.365 0 Td (the )Tj -0.0059 Tc -20.723 -1.062 Td (time )Tj 0.05 Tc 11.1292 0 0 10.4 321.01 337.21 Tm (of )Tj 0.0023 Tc 10.4 0 0 10.4 336.33 337.21 Tm (sample )Tj 0.0052 Tc 3.42 0 Td (collection; )Tj 0.0238 Tc 4.847 0 Td (in )Tj 0.0218 Tc 1.383 0 Td (addition )Tj 0.016 Tc 4.11 0 Td (it )Tj 0.0038 Tc 1.208 0 Td (reduced )Tj 0.275 0.278 0.267 rg -0.0092 Tc -18.798 -1.062 Td (slightly )Tj 0.208 0.212 0.2 rg 0.0143 Tc 3.335 0 Td (the )Tj 0.021 Tc 1.712 0 Td (plateau )Tj -0.0059 Tc 3.457 0 Td (time )Tj 0.0456 Tc 2.162 0 Td (and )Tj 0.0143 Tc 1.992 0 Td (the )Tj 0.0094 Tc 1.662 0 Td (time )Tj 0.05 Tc 11.1292 0 0 10.4 468.37 326.16 Tm (of )Tj 0.0131 Tc 10.4 0 0 10.4 481.34 326.16 Tm (deadspace )Tj 0.0099 Tc -17.807 -1.062 Td (washout. )Tj 0.0394 Tc 4.515 0 Td (The )Tj 0.0188 Tc 2.454 0 Td (reduction )Tj -0.0224 Tc 4.746 0 Td (in )Tj 0.275 0.278 0.267 rg 0.0144 Tc 1.563 0 Td (sampling )Tj 0.208 0.212 0.2 rg 0.0094 Tc 4.581 0 Td (time )Tj -0.0132 Tc 2.633 0 Td (was )Tj -0.0153 Tc -20.446 -1.061 Td (reflected )Tj -0.0224 Tc 4.192 0 Td (in )Tj 0 Tc 1.567 0 Td (a )Tj 0.275 0.278 0.267 rg -0.0063 Tc 1.288 0 Td (significantly )Tj 0.208 0.212 0.2 rg 0.0174 Tc 5.729 0 Td (greater )Tj 0.0188 Tc 3.654 0 Td (reduction )Tj 0.0238 Tc 4.746 0 Td (in )Tj -0.0186 Tc -21.233 -1.062 Td (effective )Tj 0.0229 Tc 3.658 0 Td (breathholding )Tj -0.0059 Tc 6.135 0 Td (time )Tj -0.0212 Tc 2.081 0 Td (by )Tj 0.0143 Tc 1.288 0 Td (the )Tj 0.0122 Tc 1.566 0 Td (Jones )Tj 0.0225 Tc 2.626 0 Td (and )Tj 0.0154 Tc 1.898 0 Td (Meade )Tj 0.02 Tc -19.243 -1.015 Td (method )Tj 0.0204 Tc 3.408 0 Td (compared )Tj 0.0095 Tc 4.439 0 Td (with )Tj 0.0143 Tc 2.167 0 Td (the )Tj 0.0342 Tc 1.562 0 Td (other )Tj 0.0153 Tc 2.5 0 Td (methods. )Tj 0.0163 Tc -13.114 -1.062 Td (The )Tj 0.0084 Tc 1.891 0 Td (discrepancy )Tj -0.0224 Tc 5.216 0 Td (in )Tj 0.275 0.278 0.267 rg 0.0194 Tc 1.113 0 Td (transfer )Tj 0.208 0.212 0.2 rg 0.0196 Tc 3.499 0 Td (factor )Tj 0.0084 Tc 2.769 0 Td (\(TI\) )Tj 0.0098 Tc 1.995 0 Td (was )Tj 0.0215 Tc 1.884 0 Td (due )Tj 0.275 0.278 0.267 rg 0.01 Tc 1.853 0 Td (to )Tj -0.0084 Tc -21.192 -1.061 Td (all )Tj 0.208 0.212 0.2 rg 0.0143 Tc 1.346 0 Td (the )Tj 0.0053 Tc 1.561 0 Td (factors )Tj -0.0094 Tc 3.149 0 Td (which )Tj -0.0051 Tc 2.762 0 Td (influenced )Tj 0.275 0.278 0.267 rg 0.0143 Tc 4.529 0 Td (the )Tj 0.208 0.212 0.2 rg 0.0197 Tc 1.562 0 Td (change )Tj -0.0224 Tc 3.232 0 Td (in )Tj 0.0032 Tc 1.106 0 Td (airway )Tj 0.0045 Tc -19.245 -1.062 Td (calibre )Tj 0.0132 Tc 3.364 0 Td (so )Tj 0.0143 Tc 1.581 0 Td (the )Tj 0.0178 Tc 1.94 0 Td (result )Tj 0.0184 Tc 2.907 0 Td (might )Tj -0.0103 Tc 3.095 0 Td (be )Tj -0.0031 Tc 1.558 0 Td (expected )Tj 0.05 Tc 10.4772 0 0 10.4 490.53 249.37 Tm (to )Tj 0.0098 Tc 10.4 0 0 10.4 505.9 249.37 Tm (vary )Tj -0.0069 Tc -20.166 -1.062 Td (between )Tj 0.0191 Tc 3.878 0 Td (patients )Tj 0.0456 Tc 3.772 0 Td (and )Tj 0.0072 Tc 2.133 0 Td (within )Tj 0.0143 Tc 3.183 0 Td (the )Tj 0.0167 Tc 1.788 0 Td (same )Tj 0.0191 Tc 2.647 0 Td (patients )Tj -0.0224 Tc 3.82 0 Td (in )Tj 0.0127 Tc -21.223 -1.016 Td (relation )Tj 0.05 Tc 10.4772 0 0 10.4 332.61 227.76 Tm (to )Tj 0.0186 Tc 10.4 0 0 10.4 345.01 227.76 Tm (acute )Tj 0.0133 Tc 2.538 0 Td (exacerbations )Tj 0.05 Tc 11.1292 0 0 10.4 433.81 227.76 Tm (or )Tj 0.0194 Tc 10.4 0 0 10.4 446.78 227.76 Tm (chronic )Tj 0.0158 Tc 3.462 0 Td (deteriora\255)Tj -0.0004 Tc -17.947 -1.061 Td (tion. )Tj 0.0315 Tc 2.348 0 Td (Thus )Tj 0.0017 Tc 2.592 0 Td (whilst )Tj 0.0238 Tc 2.946 0 Td (in )Tj 0.0143 Tc 1.344 0 Td (the )Tj 0.013 Tc 1.759 0 Td (present )Tj 0.011 Tc 3.45 0 Td (circumstances )Tj 0.0143 Tc 6.284 0 Td (the )Tj 0.0271 Tc -20.731 -1.062 Td (error )Tj 0.0238 Tc 2.263 0 Td (in )Tj 0.02 Tc 1.068 0 Td (method )Tj 0 Tc 3.412 0 Td (2 )Tj 0.0098 Tc 0.697 0 Td (was )Tj 0.026 Tc 1.836 0 Td (3.9%, )Tj -0.0224 Tc 2.68 0 Td (in )Tj 0.0226 Tc 1.061 0 Td (other )Tj 0.0072 Tc 2.4 0 Td (circumstances )Tj 0.016 Tc 6.001 0 Td (it )Tj 0.0154 Tc -21.463 -1.062 Td (could )Tj -0.0103 Tc 2.872 0 Td (be )Tj 0.0248 Tc 1.474 0 Td (more )Tj 0.275 0.278 0.267 rg 0.0456 Tc 2.668 0 Td (and )Tj 0.208 0.212 0.2 rg 0.0269 Tc 2.078 0 Td (could )Tj 0.0231 Tc 2.863 0 Td (interact )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0059 Tc 10.4 0 0 10.4 458.3968 194.636 Tm (with )Tj EMC ET BT /T1_0 1 Tf 0.0143 Tc 10.4 0 0 10.4 483.336 194.636 Tm (the )Tj 0.0342 Tc 1.793 0 Td (other )Tj -0.003 Tc -19.805 -1.062 Td (sources )Tj 0.05 Tc 11.1292 0 0 10.4 331.09 183.61 Tm (of )Tj 10.4041 0 0 10.4 343.57 183.61 Tm (error )Tj 0.0238 Tc 10.4 0 0 10.4 369.51 183.61 Tm (in )Tj 0.0143 Tc 1.206 0 Td (the )Tj 0.0126 Tc 1.663 0 Td (measurement )Tj -0.035 Tc 10.2034 0 0 10.4 460.07 183.61 Tm ([14]. )Tj 0.0394 Tc 10.4 0 0 10.4 482.31 183.61 Tm (The )Tj 0.0387 Tc 1.983 0 Td (error )Tj -0.0094 Tc -19.938 -1.015 Td (affected )Tj 0.0145 Tc 3.705 0 Td (particularly )Tj 0.0143 Tc 5.257 0 Td (the )Tj -0.007 Tc 1.801 0 Td (modified )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.011 Tc 10.4 0 0 10.4 449.6748 173.054 Tm (Ogilvie )Tj EMC ET BT /T1_0 1 Tf 0.0456 Tc 10.4 0 0 10.4 485.1804 173.054 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0007 Tc 10.4 0 0 10.4 506.8332 173.054 Tm (ESP )Tj EMC ET BT /T1_0 1 Tf 0.0087 Tc 10.4 0 0 10.4 295.6716 162.0092 Tm (methods. )Tj 0.05 Tc 11.1577 0 0 10.4 340.72 162.01 Tm (It )Tj -0.0094 Tc 10.4 0 0 10.4 354.13 162.01 Tm (affected )Tj 0.0373 Tc 3.792 0 Td (the )Tj 0.0076 Tc 1.847 0 Td (volume-corrected )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0147 Tc 10.4 0 0 10.4 493.9268 162.01 Tm (breath\255)Tj EMC ET BT /T1_0 1 Tf 10.4 0 0 10.4 295.6716 150.9652 Tm (holding )Tj 0.02 Tc 3.553 0 Td (method )Tj 0.05 Tc 11.6856 0 0 10.4 369.97 150.97 Tm (of )Tj 0.0337 Tc 10.4 0 0 10.4 383.95 150.97 Tm (Morgan )Tj 0.01 Tc 3.833 0 Td (to )Tj 0 Tc 1.238 0 Td (a )Tj -0.0087 Tc 0.971 0 Td (lesser )Tj 0.0011 Tc 2.675 0 Td (extent. )Tj 0.0394 Tc 3.187 0 Td (The )Tj 0.0271 Tc -20.402 -1.062 Td (error )Tj -0.0132 Tc 2.363 0 Td (was )Tj 0.0131 Tc 1.883 0 Td (avoided )Tj 0.025 Tc 3.612 0 Td (by )Tj -0.0195 Tc 1.384 0 Td (use )Tj 0.05 Tc 11.1292 0 0 10.4 408.37 139.93 Tm (of )Tj 10.5142 0 0 10.4 420.39 139.93 Tm (TI'. )Tj 0.003 Tc 10.4 0 0 10.4 440.59 139.93 Tm (However, )Tj 0.0143 Tc 4.294 0 Td (the )Tj 0.0269 Tc 1.61 0 Td (latter )Tj -0.0087 Tc -19.846 -1.062 Td (index )Tj -0.0132 Tc 2.5 0 Td (was )Tj 0.275 0.278 0.267 rg 0.0028 Tc 1.787 0 Td (systematically )Tj 0.208 0.212 0.2 rg 0.0004 Tc 6.052 0 Td (lower )Tj 0.0274 Tc 2.544 0 Td (than )Tj 0.05 Tc 10.8137 0 0 10.4 451.11 128.89 Tm (TI )Tj 0.025 Tc 10.4 0 0 10.4 464.65 128.89 Tm (by )Tj 0.0358 Tc 1.282 0 Td (on )Tj 0.0074 Tc 1.337 0 Td (average )Tj -0.027 Tc -18.763 -1.062 Td (12% )Tj -0.0008 Tc 2.112 0 Td (before )Tj 0.0235 Tc 2.8 0 Td (salbutamol )Tj 0.0215 Tc (due )Tj 0.05 Tc 10.4772 0 0 10.4 417.09 117.84 Tm (to )Tj 0.0143 Tc 10.4 0 0 10.4 429.09 117.84 Tm (the )Tj -0.0054 Tc 1.525 0 Td (res)Tj 0.098 0.102 0.09 rg 0 Tc 1.146 0 Td (i)Tj 0.208 0.212 0.2 rg 0.0297 Tc 0.276 0 Td (dual )Tj 0.0017 Tc 2.085 0 Td (volume )Tj 0.05 Tc 11.1292 0 0 10.4 515.89 117.84 Tm (of )Tj 0.0143 Tc 10.4 0 0 10.4 295.65 107.28 Tm (the )Tj 0.0191 Tc 1.482 0 Td (patients )Tj 0.0012 Tc 3.461 0 Td (being )Tj 0.0171 Tc 2.445 0 Td (underestimated )Tj 0.025 Tc 6.555 0 Td (by )Tj 0.0373 Tc 1.242 0 Td (the )Tj 0.275 0.278 0.267 rg 0.006 Tc 1.512 0 Td (single-breath )Tj 0.208 0.212 0.2 rg 0.0094 Tc -16.691 -1.061 Td (procedure )Tj 0.0074 Tc 4.879 0 Td (for )Tj 0.0172 Tc 1.994 0 Td (measurement)Tj 0.349 0.353 0.341 rg 0 Tc 5.515 0 Td (: )Tj 0.208 0.212 0.2 rg 0.0135 Tc 0.986 0 Td (This )Tj 0.0098 Tc 2.592 0 Td (was )Tj 0.0058 Tc 2.344 0 Td (also )Tj 0.0373 Tc 2.408 0 Td (the )Tj -0.0014 Tc -20.777 -1.062 Td (experience )Tj 0.05 Tc 11.1292 0 0 10.4 344.53 85.2 Tm (of )Tj 0.0234 Tc 10.4 0 0 10.4 357.98 85.2 Tm (others )Tj -0.035 Tc 9.9277 0 0 10.4 389.52 85.2 Tm ([19]. )Tj 0.0394 Tc 10.4 0 0 10.4 412.23 85.2 Tm (The )Tj 0.0184 Tc 2.086 0 Td (underestimation )Tj 0.0098 Tc 7.153 0 Td (was )Tj ET endstream endobj 40 0 obj 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0.361 0.365 0.349 rg 0.05 Tc 8.0851 0 0 7.6 389.27 767.29 Tm (AMOL )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_1 1 Tf -0.035 Tc 7.7539 0 0 10 527.46 766.8 Tm (21 )Tj /T1_0 1 Tf 0.0012 Tc 10.3 0 0 10.3 58.07 743.29 Tm (reduced )Tj -0.0118 Tc 3.637 0 Td (by )Tj 0.0258 Tc 1.383 0 Td (salbutamo)Tj 0.204 0.208 0.196 rg 0 Tc 4.34 0 Td (l )Tj 0.302 0.306 0.29 rg 0.042 Tc 0.662 0 Td (but )Tj -0.003 Tc 1.814 0 Td (the )Tj 0.361 0.365 0.349 rg 0.0059 Tc 1.624 0 Td (coi)Tj 0.204 0.208 0.196 rg 0 Tc 1.267 0 Td (n)Tj 0.302 0.306 0.29 rg -0.0077 Tc 0.504 0 Td (cidence )Tj 0.0299 Tc 3.455 0 Td (that )Tj 0.361 0.365 0.349 rg -0.003 Tc 2.097 0 Td (the )Tj -0.0217 Tc -20.839 -1.025 Td (effect )Tj 0.302 0.306 0.29 rg 0.05 Tc 11.1292 0 0 10.3 86.29 732.73 Tm (of )Tj 0.361 0.365 0.349 rg 0.0013 Tc 10.3 0 0 10.3 101.73 732.73 Tm (this )Tj 0.302 0.306 0.29 rg 0.0068 Tc 2.09 0 Td (change )Tj -0.0058 Tc 3.504 0 Td (was )Tj 0.361 0.365 0.349 rg 0.0043 Tc 2.134 0 Td (exactly )Tj 0.302 0.306 0.29 rg -0.0026 Tc 3.496 0 Td (cancelled )Tj -0.035 Tc 10.0482 0 0 10.3 263.53 732.73 Tm (by )Tj 0 Tc 10.3 0 0 10.3 279.73 732.73 Tm (a )Tj 0.361 0.365 0.349 rg 0.0015 Tc -21.576 -1.073 Td (converse )Tj 0.302 0.306 0.29 rg 0.0161 Tc 3.868 0 Td (change )Tj -0.035 Tc 9.9195 0 0 10.3 130.96 721.68 Tm (in )Tj 0 Tc 10.3 0 0 10.3 142.53 721.68 Tm (t)Tj 0.204 0.208 0.196 rg 0.282 0 Td (h)Tj 0.302 0.306 0.29 rg 0.55 0 Td (e )Tj 0.361 0.365 0.349 rg 0.0077 Tc 0.746 0 Td (estimated )Tj 0.302 0.306 0.29 rg 0.0277 Tc 4.299 0 Td (breat)Tj 0.204 0.208 0.196 rg 0 Tc 2.142 0 Td (h)Tj 0.302 0.306 0.29 rg -0.0307 Tc 0.559 0 Td (hol)Tj 0.204 0.208 0.196 rg 0 Tc 1.296 0 Td (d)Tj 0.302 0.306 0.29 rg 0.514 0 Td (i)Tj 0.204 0.208 0.196 rg 0.287 0 Td (n)Tj 0.302 0.306 0.29 rg 0.505 0 Td (g )Tj -0.0158 Tc 0.891 0 Td (time )Tj 0.0124 Tc -20.33 -1.025 Td (should )Tj 0.0156 Tc 3.089 0 Td (not )Tj -0.035 Tc 10.1515 0 0 10.3 106.57 711.12 Tm (be )Tj -0.0072 Tc 10.3 0 0 10.3 118.55 711.12 Tm (relied )Tj 0.0456 Tc 2.554 0 Td (on )Tj -0.0152 Tc 1.352 0 Td (in )Tj 0.0394 Tc 1.071 0 Td (other )Tj 0 Tc 2.423 0 Td (c)Tj 0.204 0.208 0.196 rg 0.467 0 Td (i)Tj 0.302 0.306 0.29 rg 0.0167 Tc 0.287 0 Td (rcumsta)Tj 0.204 0.208 0.196 rg 0 Tc 3.309 0 Td (n)Tj 0.302 0.306 0.29 rg -0.035 Tc 10.2862 0 0 10.3 241.82 711.12 Tm (ces. )Tj 0 Tc 10.3 0 0 10.3 259.59 711.12 Tm (T)Tj 0.204 0.208 0.196 rg 0.707 0 Td (h)Tj 0.302 0.306 0.29 rg -0.0218 Tc 0.503 0 Td (ese )Tj 0.0003 Tc -20.821 -1.071 Td (results )Tj 0.0207 Tc 3.02 0 Td (demonstrate )Tj 0.0299 Tc 5.506 0 Td (that )Tj 0.0132 Tc 1.996 0 Td (for )Tj 0.0169 Tc 1.597 0 Td (patients )Tj -0.0043 Tc 3.585 0 Td (receiving )Tj 0.0201 Tc 4.056 0 Td (bron\255)Tj 0.0286 Tc -19.817 -1.072 Td (chodilator )Tj 0.0137 Tc 4.76 0 Td (therapy )Tj -0.003 Tc 3.588 0 Td (the )Tj 0.361 0.365 0.349 rg 0.0172 Tc 1.678 0 Td (transfer )Tj 0.302 0.306 0.29 rg 0.015 Tc 3.627 0 Td (factor )Tj -0.035 Tc 10.1489 0 0 10.3 227.44 689.05 Tm (is )Tj 0.0106 Tc 10.3 0 0 10.3 238.57 689.05 Tm (best )Tj 0.001 Tc 2.094 0 Td (meas)Tj 0.204 0.208 0.196 rg 0 Tc 2.041 0 Td (\255)Tj 0.302 0.306 0.29 rg -0.0015 Tc -21.705 -1.073 Td (ured )Tj -0.035 Tc 10.0482 0 0 10.3 82.09 678 Tm (by )Tj 0.361 0.365 0.349 rg -0.003 Tc 10.3 0 0 10.3 97.41 678 Tm (the )Tj 0.302 0.306 0.29 rg 0.0166 Tc 1.725 0 Td (method )Tj 0.05 Tc 11.1292 0 0 10.3 152.53 678 Tm (of )Tj 0.006 Tc 10.3 0 0 10.3 166.5 678 Tm (Jones )Tj 0.361 0.365 0.349 rg 0.0297 Tc 2.745 0 Td (and )Tj 0.302 0.306 0.29 rg 0.0105 Tc 2.103 0 Td (Meade )Tj 0.0153 Tc 3.266 0 Td (with )Tj 0.0467 Tc 2.32 0 Td (an )Tj 0.012 Tc -21.016 -1.025 Td (independent )Tj 0.007 Tc 5.497 0 Td (estimate )Tj 0.05 Tc 10.5727 0 0 10.3 153.98 667.44 Tm (of )Tj 0.361 0.365 0.349 rg 0.0085 Tc 10.3 0 0 10.3 167.51 667.44 Tm (residua)Tj 0.204 0.208 0.196 rg 0 Tc 2.975 0 Td (l )Tj 0.302 0.306 0.29 rg -0.0043 Tc 0.706 0 Td (volume. )Tj 0.0084 Tc 3.818 0 Td (Measure\255)Tj -0.0012 Tc -18.172 -1.071 Td (ments )Tj -0.0118 Tc 2.846 0 Td (by )Tj 0.0278 Tc 1.387 0 Td (other )Tj 0.361 0.365 0.349 rg 0.0112 Tc 2.571 0 Td (methods )Tj 0.0252 Tc 3.906 0 Td (are )Tj 0.302 0.306 0.29 rg 0.0023 Tc 1.68 0 Td (inherently )Tj -0.0282 Tc 4.52 0 Td (less )Tj -0.0034 Tc 1.825 0 Td (reliable. )Tj 0.361 0.365 0.349 rg 0.0038 Tc -18.788 -1.025 Td (This )Tj 0.302 0.306 0.29 rg -0.0087 Tc 2.198 0 Td (needs )Tj 0.0176 Tc 2.701 0 Td (to )Tj -0.0014 Tc 1.216 0 Td (be )Tj 0.0159 Tc 1.351 0 Td (borne )Tj -0.0152 Tc 2.74 0 Td (in )Tj 0.0003 Tc 1.172 0 Td (mind )Tj -0.0056 Tc 2.517 0 Td (when )Tj 0.0174 Tc 2.566 0 Td (proposals )Tj -0.0101 Tc 4.415 0 Td (for )Tj 0.361 0.365 0.349 rg 0.022 Tc -20.882 -1.073 Td (standardization )Tj 0.05 Tc 10.5727 0 0 10.3 127.1 634.8 Tm (of )Tj 0.302 0.306 0.29 rg -0.003 Tc 10.3 0 0 10.3 139.17 634.8 Tm (the )Tj 0.0085 Tc 1.585 0 Td (measurement )Tj 0.0485 Tc 5.77 0 Td (are )Tj -0.0112 Tc 1.641 0 Td (reviewed. )Tj /T1_2 1 Tf 0 Tc 8.1 0 0 8.1 112.92 618.48 Tm (A)Tj 0.204 0.208 0.196 rg 0.63 0 Td (c)Tj 0.302 0.306 0.29 rg -0.0019 Tc 0.479 0 Td (knowledge)Tj 0.204 0.208 0.196 rg 0 Tc 4.264 0 Td (m)Tj 0.302 0.306 0.29 rg 0.767 0 Td (e)Tj 0.204 0.208 0.196 rg 0.419 0 Td (n)Tj 0.302 0.306 0.29 rg 0.0073 Tc 0.527 0 Td (ts: )Tj /T1_0 1 Tf -0.035 Tc 8.2123 0 0 8.3 181.41 618.48 Tm (We )Tj 0.361 0.365 0.349 rg 0.0322 Tc 8.3 0 0 8.3 195.28 618.48 Tm (are )Tj 0.0066 Tc 1.62 0 Td (indebted )Tj 0.302 0.306 0.29 rg -0.0228 Tc 3.881 0 Td (to )Tj 0.361 0.365 0.349 rg -0.0016 Tc 1.157 0 Td (the )Tj 0.302 0.306 0.29 rg -0.0006 Tc 1.617 0 Td (Medi\255)Tj -0.0221 Tc -19.205 -1.099 Td (cal )Tj -0.002 Tc 1.508 0 Td (Research )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0112 Tc 8.3 0 0 8.3 150.1612 609.3583 Tm (Council, )Tj EMC ET BT /T1_0 1 Tf -0.0054 Tc 8.3 0 0 8.3 182.3901 609.3583 Tm (University )Tj 0.05 Tc 8.9033 0 0 8.3 219.76 609.36 Tm (of )Tj 0.302 0.306 0.29 rg 0.0051 Tc 8.3 0 0 8.3 229.48 609.36 Tm (Newcast)Tj 0.204 0.208 0.196 rg 0 Tc 3.457 0 Td (l)Tj 0.302 0.306 0.29 rg 0.287 0 Td (e )Tj 0.0275 Tc 0.705 0 Td (upon )Tj 0.0151 Tc -19.498 -1.04 Td (Tyne )Tj 0.0358 Tc 2.428 0 Td (and )Tj 0.0298 Tc 1.981 0 Td (Northern )Tj -0.0026 Tc 4.27 0 Td (Regional )Tj 0.025 Tc 4.048 0 Td (Health )Tj 0.0282 Tc 3.184 0 Td (Authority )Tj 0.0146 Tc 4.501 0 Td (for )Tj -0.0125 Tc -20.414 -1.099 Td (financial )Tj 0.0186 Tc 3.813 0 Td (support. )Tj 0 Tc 3.767 0 Td (J)Tj 0.071 0.074 0.059 rg 0.506 0 Td (.)Tj 0.361 0.365 0.349 rg -0.035 Tc 8.2744 0 0 8.3 173.71 591.61 Tm (E. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.015 Tc 8.3 0 0 8.3 183.76 591.61 Tm (Cotes )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 7.8068 0 0 8.3 206.34 591.61 Tm (is )Tj 0.0071 Tc 8.3 0 0 8.3 214.48 591.61 Tm (also )Tj 0.302 0.306 0.29 rg 0.0066 Tc 2.025 0 Td (indebted )Tj 0.204 0.208 0.196 rg 0 Tc 3.881 0 Td (t)Tj 0.302 0.306 0.29 rg 0.282 0 Td (o )Tj 0.0273 Tc 0.933 0 Td (the )Tj 0 Tc -20.355 -1.041 Td (American )Tj 0.0241 Tc 4.272 0 Td (Thoracic )Tj -0.002 Tc 3.923 0 Td (Society )Tj -0.0012 Tc 3.255 0 Td (whose )Tj 0.361 0.365 0.349 rg 0.0091 Tc 2.825 0 Td (consensus )Tj 0.302 0.306 0.29 rg 0.0141 Tc 4.395 0 Td (confer)Tj 0.204 0.208 0.196 rg 0 Tc 2.6 0 Td (\255)Tj 0.302 0.306 0.29 rg -0.0055 Tc -21.339 -1.099 Td (ence )Tj 0.05 Tc 8.3916 0 0 8.3 121.84 573.85 Tm (on )Tj 0.361 0.365 0.349 rg 0.0203 Tc 8.3 0 0 8.3 133.32 573.85 Tm (standardization )Tj 0.0161 Tc 6.708 0 Td (stimulated )Tj 0.302 0.306 0.29 rg -0.0176 Tc 4.696 0 Td (this )Tj 0.361 0.365 0.349 rg 0.0076 Tc 1.723 0 Td (study. )Tj 0.302 0.306 0.29 rg 0.0388 Tc 8.8 0 0 8.8 149.72 530.65 Tm (Re)Tj 0.204 0.208 0.196 rg 0 Tc 1.139 0 Td (f)Tj 0.302 0.306 0.29 rg 0.328 0 Td (e)Tj 0.204 0.208 0.196 rg 0.5 0 Td (r)Tj 0.302 0.306 0.29 rg 0.373 0 Td (e)Tj 0.204 0.208 0.196 rg 0.445 0 Td (n)Tj 0.302 0.306 0.29 rg 0.0271 Tc 0.482 0 Td (ces )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 8.7408 0 0 8.1 56.88 515.76 Tm (I. )Tj EMC ET BT /T1_0 1 Tf 0.0087 Tc 8.3 0 0 8.3 70.52 515.76 Tm (Bouhuys )Tj -0.035 Tc 8.2476 0 0 8.3 102.71 515.76 Tm (A, )Tj 0.0443 Tc 8.3 0 0 8.3 112.72 515.76 Tm (Georg )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0053 Tc 8.3 0 0 8.3 136.7485 515.76 Tm (J, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0133 Tc 8.3 0 0 8.3 144.426 515.76 Tm (Jonsson )Tj -0.035 Tc 8.194 0 0 8.3 174.68 515.76 Tm (R, )Tj 0.0034 Tc 8.3 0 0 8.3 185.24 515.76 Tm (Lundin )Tj 0 Tc 3.234 0 Td (G)Tj 0.451 0.455 0.439 rg 0.804 0 Td (, )Tj 0.302 0.306 0.29 rg -0.016 Tc 0.589 0 Td (Lindell )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0257 Tc 8.3 0 0 8.3 249.4571 515.76 Tm (SE.)Tj 0.569 0.572 0.557 rg 0 Tc 1.683 0 Td (-)Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0414 Tc 8.3 0 0 8.3 270.1739 515.76 Tm (The )Tj 0.302 0.306 0.29 rg -0.0071 Tc -25.793 -1.098 Td (influence )Tj 0.05 Tc 8.9033 0 0 8.3 91.6 506.65 Tm (of )Tj -0.0006 Tc 8.3 0 0 8.3 104.15 506.65 Tm (histamine )Tj 0.0142 Tc 4.561 0 Td (inhalation )Tj 0.361 0.365 0.349 rg 0.0035 Tc 4.799 0 Td (on )Tj 0.0273 Tc 1.684 0 Td (the )Tj 0.302 0.306 0.29 rg 0.0165 Tc 1.912 0 Td (pulmonary )Tj -0.0018 Tc 5.078 0 Td (diffusing )Tj 0.0152 Tc -23.884 -1.099 Td (capacity )Tj -0.009 Tc 3.76 0 Td (in )Tj 0.361 0.365 0.349 rg 0.0002 Tc 1.163 0 Td (man. )Tj 0.302 0.306 0.29 rg /T1_3 1 Tf 0 Tc 7.1 0 0 7.1 116.09 497.53 Tm (J )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0027 Tc 8.1 0 0 8.1 122.94 497.53 Tm (Physiol)Tj 0.451 0.455 0.439 rg 0 Tc (, )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 8.1597 0 0 8.3 152.84 497.53 Tm (1960)Tj 0.451 0.455 0.439 rg 0 Tc 8.3 0 0 8.3 167.87 497.53 Tm (, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.7728 0 0 8.3 173.49 497.53 Tm (152)Tj 0.451 0.455 0.439 rg 0 Tc 8.3 0 0 8.3 184.67 497.53 Tm (, )Tj 0.302 0.306 0.29 rg -0.035 Tc 7.7728 0 0 8.3 190.29 497.53 Tm (176)Tj 0.569 0.572 0.557 rg 0 Tc 8.3 0 0 8.3 201.5 497.53 Tm (-)Tj 0.302 0.306 0.29 rg -0.035 Tc 8.236 0 0 8.3 206.6 497.53 Tm (181. )Tj 0.361 0.365 0.349 rg 7.5852 0 0 8.3 56.12 488.89 Tm (2. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0252 Tc 8.3 0 0 8.3 70 488.89 Tm (Chandler )Tj EMC /Suspect <>BDC -0.0004 Tc 4.511 0 Td (CL, )Tj EMC /Suspect <>BDC 0.0163 Tc 2.198 0 Td (Chinn )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.05 Tc 8.3077 0 0 8.3 152.12 488.89 Tm (DJ, )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.015 Tc 8.3 0 0 8.3 169.36 488.89 Tm (Cotes )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0157 Tc 8.3 0 0 8.3 194.3513 488.89 Tm (JE. )Tj 0.361 0.365 0.349 rg 0 Tc 1.96 0 Td (-)Tj 0.302 0.306 0.29 rg -0.0226 Tc 1.278 0 Td (Effect )Tj 0.05 Tc 9.4598 0 0 8.3 245.67 488.89 Tm (of )Tj 0.0043 Tc 8.3 0 0 8.3 258.65 488.89 Tm (inhaled )Tj 0.0067 Tc -24.398 -1.1 Td (histamine )Tj 0.361 0.365 0.349 rg 0.0035 Tc 4.676 0 Td (on )Tj 0.302 0.306 0.29 rg -0.0095 Tc 1.788 0 Td (single )Tj 0.0116 Tc 3.081 0 Td (breath )Tj -0.0089 Tc 3.402 0 Td (lung )Tj 0.0106 Tc 2.551 0 Td (transfer )Tj 0.361 0.365 0.349 rg 0.0161 Tc 3.866 0 Td (factor )Tj 0.302 0.306 0.29 rg 0.0146 Tc 3.181 0 Td (for )Tj 0.361 0.365 0.349 rg 0.0385 Tc 1.91 0 Td (carbon )Tj 0.302 0.306 0.29 rg 0.0245 Tc -24.513 -1.041 Td (monoxide)Tj 0.451 0.455 0.439 rg 0 Tc 4.146 0 Td (. )Tj 0.302 0.306 0.29 rg /T1_3 1 Tf 7.1 0 0 7.1 94.49 471.12 Tm (J )Tj /T1_2 1 Tf 0.0004 Tc 8.1 0 0 8.1 101.34 471.12 Tm (Physiol, )Tj /T1_0 1 Tf -0.035 Tc 8.0056 0 0 8.3 131.72 471.12 Tm (1982, )Tj 0.361 0.365 0.349 rg -0.0313 Tc 8.3 0 0 8.3 151.58 471.12 Tm (327, )Tj 0.0429 Tc 2.018 0 Td (Slp. )Tj 0.451 0.455 0.439 rg -0.035 Tc 7.7865 0 0 8.3 56.07 462 Tm (3. )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0198 Tc 8.3 0 0 8.3 70 462 Tm (Comroe )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.05 Tc 8.7436 0 0 8.3 100.75 462 Tm (JH)Tj 0.204 0.208 0.196 rg 0 Tc 8.3 0 0 8.3 111.19 462 Tm (. )Tj 0.451 0.455 0.439 rg 0.645 0 Td (-)Tj 0.302 0.306 0.29 rg 0.0029 Tc 1.106 0 Td (Harnessing )Tj 0.361 0.365 0.349 rg 0.027 Tc 4.911 0 Td (carbon )Tj 0.302 0.306 0.29 rg 0.0046 Tc 3.304 0 Td (monoxide. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 7.6628 0 0 8.7 233.84 462 Tm (In: )Tj EMC ET BT /T1_0 1 Tf 0.0078 Tc 8.3 0 0 8.3 246.68 462 Tm (Retrospec\255)Tj 0.0013 Tc -22.957 -1.098 Td (troscope. )Tj 0.0126 Tc 4.448 0 Td (Insights )Tj 0.361 0.365 0.349 rg 0.0271 Tc 3.989 0 Td (into )Tj 0.302 0.306 0.29 rg -0.0054 Tc 2.377 0 Td (medical )Tj 0.361 0.365 0.349 rg -0.0086 Tc 3.925 0 Td (discovery. )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0098 Tc 8.3 0 0 8.3 218.8501 452.8866 Tm (Von )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.3266 0 0 8.3 239.44 452.89 Tm (Gehr )Tj 0.204 0.208 0.196 rg 0 Tc 8.3 0 0 8.3 263.96 452.89 Tm (P)Tj 0.361 0.365 0.349 rg -0.0172 Tc 0.582 0 Td (ress, )Tj 0.0118 Tc -25.686 -1.041 Td (California. )Tj -0.035 Tc 8.241 0 0 8.3 96.2 444.25 Tm (1977, )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0192 Tc 8.3 0 0 8.3 116.11 444.25 Tm (27-30. )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 55.6528 435.12 Tm (4)Tj 0.451 0.455 0.439 rg 0.504 0 Td (. )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.015 Tc 8.3 0 0 8.3 69.5221 435.12 Tm (Cotes )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0157 Tc 8.3 0 0 8.3 93.0692 435.12 Tm (JE. )Tj 0.714 0.718 0.702 rg 0 Tc 1.845 0 Td (-)Tj 0.302 0.306 0.29 rg 0.014 Tc 1.106 0 Td (Lung )Tj 0.0055 Tc 2.596 0 Td (function. )Tj 0.361 0.365 0.349 rg -0.0031 Tc 4.173 0 Td (Assessment )Tj 0.05 Tc 8.4599 0 0 8.3 217.35 435.12 Tm (and )Tj 0.0201 Tc 8.3 0 0 8.3 234.16 435.12 Tm (application )Tj 0.451 0.455 0.439 rg 0 Tc 5.148 0 Td (i)Tj 0.302 0.306 0.29 rg 0.239 0 Td (n )Tj -0.0111 Tc -26.893 -1.04 Td (medicine. )Tj 0.361 0.365 0.349 rg 0.0053 Tc 4.336 0 Td (4th )Tj 0.302 0.306 0.29 rg 0.0087 Tc 1.786 0 Td (edition. )Tj -0.019 Tc 3.649 0 Td (Blackwell )Tj 0.361 0.365 0.349 rg -0.01 Tc 4.382 0 Td (Scientific )Tj 0.302 0.306 0.29 rg 0.0098 Tc 4.235 0 Td (Publications)Tj 0.451 0.455 0.439 rg 0 Tc 5.078 0 Td (, )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0167 Tc 8.3 0 0 8.3 256.238 426.488 Tm (Oxford)Tj 0.451 0.455 0.439 rg 0 Tc 3.054 0 Td (. )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf -0.035 Tc 8.0056 0 0 8.3 56.36 417.37 Tm (1979. )Tj /T1_2 1 Tf 7.5657 0 0 9 55.6 408.25 Tm (5. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.031 Tc 8.3 0 0 8.3 69.52 408.25 Tm (Crapo )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg -0.0082 Tc 3.07 0 Td (RO. )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 112.2235 408.25 Tm (-)Tj -0.0226 Tc 0.989 0 Td (Effect )Tj 0.05 Tc 8.9033 0 0 8.3 143.44 408.25 Tm (of )Tj 0.302 0.306 0.29 rg 0.0273 Tc 8.3 0 0 8.3 153.58 408.25 Tm (the )Tj 0.361 0.365 0.349 rg 0.0145 Tc 1.677 0 Td (method )Tj 0.05 Tc 8.9033 0 0 8.3 196.72 408.25 Tm (of )Tj 0.0152 Tc 8.3 0 0 8.3 206.86 408.25 Tm (measuring )Tj 0.302 0.306 0.29 rg 0.0211 Tc 4.688 0 Td (breathhold )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf -0.0079 Tc 8.3 0 0 8.3 55.6091 399.12 Tm (lime )Tj EMC ET BT /T1_0 1 Tf 0.0035 Tc 8.3 0 0 8.3 73.3628 399.12 Tm (on )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.009 Tc 8.3 0 0 8.3 84.9247 399.12 Tm (Dt.)Tj 0.451 0.455 0.439 rg 0.05 Tc 8.8803 0 0 8.3 95.43 399.12 Tm (co )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 8.4599 0 0 8.3 106.95 399.12 Tm (and )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.8723 0 0 8.3 123.32 399.12 Tm (DL)Tj 0.451 0.455 0.439 rg 0 Tc 8.3 0 0 8.3 132.96 399.12 Tm (/)Tj 0.302 0.306 0.29 rg -0.035 Tc 7.1878 0 0 8.3 135.83 399.12 Tm (VA )Tj EMC ET BT /T1_0 1 Tf 7.9356 0 0 8.3 149.22 399.12 Tm (in )Tj 0.0014 Tc 8.3 0 0 8.3 158.87 399.12 Tm (normal )Tj 0.361 0.365 0.349 rg 0.0065 Tc 3.225 0 Td (subjects )Tj 0.0114 Tc 3.588 0 Td (\(Abstract\). )Tj /T1_2 1 Tf 0.05 Tc 8.3646 0 0 8.1 255.97 399.12 Tm (Am )Tj 0.302 0.306 0.29 rg -0.0058 Tc 8.1 0 0 8.1 271.26 399.12 Tm (Rev )Tj 0.0123 Tc -26.667 -1.126 Td (Respir )Tj 0.361 0.365 0.349 rg -0.0139 Tc 3.025 0 Td (Dis. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.0056 0 0 8.3 96.68 390 Tm (1980, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 7.0662 0 0 8.3 117.36 390 Tm (121 )Tj 0.361 0.365 0.349 rg 0.0392 Tc 8.3 0 0 8.3 130.94 390 Tm (\(part )Tj -0.0116 Tc 2.377 0 Td (2\), )Tj -0.0313 Tc 1.382 0 Td (331. )Tj -0.035 Tc 7.6478 0 0 8.3 55.11 381.37 Tm (6. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0455 Tc 8.3 0 0 8.3 69.04 381.37 Tm (Crapo )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg -0.0082 Tc 2.896 0 Td (RO.)Tj 0.451 0.455 0.439 rg 0 Tc 1.901 0 Td (-)Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg -0.0063 Tc 0.804 0 Td (Single )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 138.2454 381.37 Tm (b)Tj 0.204 0.208 0.196 rg 0.518 0 Td (r)Tj 0.361 0.365 0.349 rg 0.0306 Tc 0.337 0 Td (eath )Tj 0.027 Tc 1.967 0 Td (carbon )Tj 0.302 0.306 0.29 rg 0.0079 Tc 3.13 0 Td (monoxide )Tj -0.0018 Tc 4.272 0 Td (diffusing )Tj 0.361 0.365 0.349 rg 0.0152 Tc 3.759 0 Td (capacity )Tj 0.0148 Tc -24.002 -1.099 Td (\(Transfer )Tj 0.302 0.306 0.29 rg 0.0026 Tc 4.107 0 Td (factor\). )Tj 0.0102 Tc 3.36 0 Td (Recommendations )Tj 0.361 0.365 0.349 rg -0.0143 Tc 7.917 0 Td (for )Tj 0 Tc 1.447 0 Td (a )Tj 0.0323 Tc 0.747 0 Td (standard )Tj 0.302 0.306 0.29 rg 0.0065 Tc 3.945 0 Td (technique)Tj 0.451 0.455 0.439 rg 0 Tc 3.972 0 Td (. )Tj 0.302 0.306 0.29 rg /T1_3 1 Tf 0.05 Tc 7.4801 0 0 7.1 271.25 372.25 Tm (Am )Tj 0.361 0.365 0.349 rg /T1_2 1 Tf -0.0058 Tc 8.1 0 0 8.1 55.74 363.61 Tm (Rev )Tj 0.302 0.306 0.29 rg 0.0005 Tc 1.837 0 Td (Respir )Tj -0.0143 Tc 3.025 0 Td (Dis)Tj 0.451 0.455 0.439 rg 0 Tc 1.357 0 Td (, )Tj 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 8.0056 0 0 8.3 112.04 363.61 Tm (1987, )Tj 0.361 0.365 0.349 rg 7.9309 0 0 8.3 132.69 363.61 Tm (136, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.012 Tc 8.3 0 0 8.3 149.47 363.61 Tm (1299-!307. )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 7.6478 0 0 8.3 55.12 354.49 Tm (7. )Tj 0.302 0.306 0.29 rg 0.0114 Tc 8.3 0 0 8.3 69.56 354.49 Tm (Ferris )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.2921 0 0 8.3 92.12 354.49 Tm (BG )Tj EMC /Suspect <>BDC 0.361 0.365 0.349 rg 0.0078 Tc 8.3 0 0 8.3 106.46 354.49 Tm (\(Principal )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0073 Tc 8.3 0 0 8.3 142.4903 354.49 Tm (investigator\). )Tj 0.361 0.365 0.349 rg 0 Tc 5.78 0 Td (-)Tj 0.007 Tc 0.873 0 Td (Epidemiology )Tj 0.0383 Tc 6.006 0 Td (standa)Tj 0.204 0.208 0.196 rg 0 Tc 2.789 0 Td (r)Tj 0.302 0.306 0.29 rg 0.0416 Tc 0.339 0 Td (di)Tj 0.204 0.208 0.196 rg 0 Tc 0.807 0 Td (\255)Tj 0.361 0.365 0.349 rg 0.0136 Tc -27.125 -1.099 Td (sation )Tj 0.302 0.306 0.29 rg -0.001 Tc 2.849 0 Td (project. )Tj /T1_3 1 Tf 0.05 Tc 7.4801 0 0 7.1 107.09 345.37 Tm (Am )Tj /T1_2 1 Tf 0.0238 Tc 8.1 0 0 8.1 121.98 345.37 Tm (Rev )Tj 0.0005 Tc 1.896 0 Td (Respir )Tj -0.0139 Tc 2.965 0 Td (Dis, )Tj 0.361 0.365 0.349 rg /T1_0 1 Tf -0.035 Tc 8.0056 0 0 8.3 178.28 345.37 Tm (1978, )Tj 0.302 0.306 0.29 rg 7.7728 0 0 8.3 198.93 345.37 Tm (118 )Tj 0.0392 Tc 8.3 0 0 8.3 212.54 345.37 Tm (\(part )Tj 0 Tc 2.377 0 Td (2 )Tj 0.05 Tc 8.9033 0 0 8.3 238.96 345.37 Tm (of )Tj -0.035 Tc 8.2085 0 0 8.3 249.07 345.37 Tm (2\). )Tj 7.7659 0 0 8.3 55.06 336.72 Tm (8. )Tj 0.0418 Tc 8.3 0 0 8.3 69.04 336.72 Tm (Graham )Tj -0.0004 Tc (BL, )Tj 0.0333 Tc 5.672 0 Td (Mink )Tj 0.0446 Tc 2.543 0 Td (JT, )Tj 0.361 0.365 0.349 rg 0.0271 Tc 1.731 0 Td (Cotton )Tj 0.302 0.306 0.29 rg 0.0218 Tc 3.243 0 Td (DJ. )Tj 0.361 0.365 0.349 rg 0 Tc 1.786 0 Td (-)Tj 0.302 0.306 0.29 rg 0.017 Tc 0.93 0 Td (Improved )Tj 0.0152 Tc 4.335 0 Td (accuracy )Tj 0.361 0.365 0.349 rg 0.0069 Tc 3.99 0 Td (and )Tj 0.302 0.306 0.29 rg -0.0012 Tc -25.898 -1.098 Td (precision )Tj 0.361 0.365 0.349 rg 0.05 Tc 8.9033 0 0 8.3 88.24 327.61 Tm (of )Tj 0.0061 Tc 8.3 0 0 8.3 97.8 327.61 Tm (single-breath )Tj 0.302 0.306 0.29 rg -0.0018 Tc 5.614 0 Td (diffusing )Tj 0.361 0.365 0.349 rg 0.0069 Tc 3.875 0 Td (capacity )Tj 0.302 0.306 0.29 rg 0.0146 Tc 3.7 0 Td (for )Tj 0.361 0.365 0.349 rg 0.0385 Tc 1.505 0 Td (carbon )Tj 0.302 0.306 0.29 rg 0.0046 Tc 3.246 0 Td (monoxide. )Tj /T1_2 1 Tf 0.05 Tc 8.1893 0 0 8.1 55.28 318.97 Tm (IEEE )Tj 0.361 0.365 0.349 rg 0.0074 Tc 8.1 0 0 8.1 76.64 318.97 Tm (Trans )Tj 0.302 0.306 0.29 rg 0.0413 Tc 2.694 0 Td (Biomed )Tj 0.361 0.365 0.349 rg -0.012 Tc 3.496 0 Td (Eng, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.002 Tc 8.3 0 0 8.3 145.65 318.97 Tm (!980, )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.2681 0 0 8.3 165.55 318.97 Tm (27, )Tj 7.8237 0 0 8.3 178.03 318.97 Tm (221)Tj 0.784 0.784 0.773 rg 0 Tc 8.3 0 0 8.3 190.46 318.97 Tm (-)Tj 0.361 0.365 0.349 rg -0.018 Tc 0.527 0 Td (227. )Tj -0.0311 Tc -16.892 -1.1 Td (9. )Tj 0.302 0.306 0.29 rg 0.0418 Tc 1.678 0 Td (Graham )Tj -0.0293 Tc 3.937 0 Td (BL, )Tj 0.05 Tc 8.3281 0 0 8.3 116.6 309.84 Tm (Mink )Tj 0.0157 Tc 8.3 0 0 8.3 139.63 309.84 Tm (JT, )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0386 Tc 8.3 0 0 8.3 153.9973 309.84 Tm (Cotton )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0218 Tc 8.3 0 0 8.3 181.877 309.84 Tm (DJ. )Tj 0.361 0.365 0.349 rg 0 Tc 1.843 0 Td (-)Tj 0.302 0.306 0.29 rg 0.0129 Tc 0.986 0 Td (Overestimation )Tj 0.361 0.365 0.349 rg 0.05 Tc 8.9033 0 0 8.3 261.52 309.84 Tm (of )Tj -0.0016 Tc 8.3 0 0 8.3 272.62 309.84 Tm (the )Tj 0.0061 Tc -26.267 -1.099 Td (single-breath )Tj 0.027 Tc 5.614 0 Td (carbon )Tj 0.302 0.306 0.29 rg 0.0079 Tc 3.304 0 Td (monoxide )Tj 0.361 0.365 0.349 rg -0.009 Tc 4.388 0 Td (diffusing )Tj 0.0152 Tc 3.875 0 Td (capacity )Tj 0.302 0.306 0.29 rg -0.009 Tc 3.76 0 Td (in )Tj 0.012 Tc 1.166 0 Td (patients )Tj -0.0122 Tc 3.583 0 Td (with )Tj 0.361 0.365 0.349 rg -0.012 Tc -25.686 -1.098 Td (air-flow )Tj 0.0225 Tc 3.47 0 Td (obstruction. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.05 Tc 8.3646 0 0 8.1 127.81 291.61 Tm (Am )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_2 1 Tf 8.2906 0 0 8.1 142.62 291.61 Tm (Re)Tj 0.451 0.455 0.439 rg 0 Tc 8.1 0 0 8.1 152.11 291.61 Tm (v )Tj 0.302 0.306 0.29 rg 0.0123 Tc 0.725 0 Td (Respir )Tj 0.361 0.365 0.349 rg -0.0336 Tc 3.025 0 Td (Dis, )Tj /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 198.92 291.61 Tm (1984, )Tj 0.302 0.306 0.29 rg 7.9309 0 0 8.3 220.05 291.61 Tm (129, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0195 Tc 8.3 0 0 8.3 235.65 291.61 Tm (403)Tj 0.451 0.455 0.439 rg 0 Tc 1.495 0 Td (-)Tj 0.302 0.306 0.29 rg -0.0192 Tc 0.529 0 Td (408. )Tj EMC /Suspect <>BDC -0.035 Tc 7.7937 0 0 8.3 55.41 282.97 Tm (10. )Tj EMC ET BT /T1_0 1 Tf 0.0106 Tc 8.3 0 0 8.3 72.43 282.97 Tm (Jones )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.2304 0 0 8.3 94.04 282.97 Tm (RS, )Tj EMC ET BT /T1_0 1 Tf 0.0171 Tc 8.3 0 0 8.3 107.96 282.97 Tm (Meade )Tj 0.0208 Tc 3.065 0 Td (F.)Tj 0.451 0.455 0.439 rg 0 Tc 1.092 0 Td (-)Tj 0.302 0.306 0.29 rg 0.82 0 Td (A )Tj 0.0011 Tc 0.982 0 Td (theoretical )Tj 0.361 0.365 0.349 rg 0.0358 Tc 4.504 0 Td (and )Tj 0.0063 Tc 1.792 0 Td (experimental )Tj 0.0128 Tc 5.495 0 Td (analysis )Tj 0.05 Tc 8.9033 0 0 8.3 54.64 273.84 Tm (of )Tj 0.0085 Tc 8.3 0 0 8.3 64.24 273.84 Tm (anomalies )Tj 0.302 0.306 0.29 rg 0.0488 Tc 4.396 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0273 Tc 8.3 0 0 8.3 110.3797 273.84 Tm (the )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0219 Tc 8.3 0 0 8.3 122.7882 273.84 Tm (estimation )Tj 0.05 Tc 8.9033 0 0 8.3 161.68 273.84 Tm (of )Tj 0.302 0.306 0.29 rg 0.0165 Tc 8.3 0 0 8.3 171.37 273.84 Tm (pulmonary )Tj -0.009 Tc 4.789 0 Td (diffusing )Tj 0.0152 Tc 3.817 0 Td (capacity )Tj 0.361 0.365 0.349 rg -0.035 Tc 8.0386 0 0 8.3 274.57 273.84 Tm (by )Tj -0.0016 Tc 8.3 0 0 8.3 54.7 265.21 Tm (the )Tj 0.0061 Tc 1.549 0 Td (single-breath )Tj 0.302 0.306 0.29 rg 0.0261 Tc 5.622 0 Td (method)Tj 0.451 0.455 0.439 rg 0 Tc 3.163 0 Td (. )Tj 0.302 0.306 0.29 rg /T1_2 1 Tf 7.9001 0 0 7.9001 145.33 265.21 Tm (Q )Tj 8.2 0 0 8.2 154.17 265.21 Tm (J )Tj 0.361 0.365 0.349 rg 0.0466 Tc 8.1 0 0 8.1 160.86 265.21 Tm (Exp )Tj -0.0204 Tc 2.015 0 Td (Plrysiol, )Tj 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 207.08 265.21 Tm (1961, )Tj 8.2425 0 0 8.3 227.49 265.21 Tm (46, )Tj 0.361 0.365 0.349 rg 7.4195 0 0 8.3 241.18 265.21 Tm (131)Tj 0.647 0.647 0.643 rg 0 Tc 8.3 0 0 8.3 252.38 265.21 Tm (-)Tj 0.361 0.365 0.349 rg -0.035 Tc 7.9309 0 0 8.3 257.97 265.21 Tm (143. )Tj 0.302 0.306 0.29 rg 0.0409 Tc 8.3 0 0 8.3 55.62 256.09 Tm (II. )Tj 0.0154 Tc 2.084 0 Td (Knudson )Tj -0.0152 Tc 4.222 0 Td (RJ, )Tj 0.0237 Tc 1.793 0 Td (Kaltenbom )Tj -0.0018 Tc 5.09 0 Td (WT, )Tj 0.025 Tc 2.196 0 Td (Knudson )Tj 0.0269 Tc 4.164 0 Td (DE, )Tj 0.0177 Tc 2.024 0 Td (Burrows )Tj 0 Tc 3.99 0 Td (B)Tj 0.451 0.455 0.439 rg 0.563 0 Td (. )Tj 0.647 0.647 0.643 rg 0.645 0 Td (-)Tj 0.361 0.365 0.349 rg 0.0124 Tc -26.946 -1.099 Td (The )Tj 0.0061 Tc 1.96 0 Td (single-breath )Tj 0.302 0.306 0.29 rg 0.0385 Tc 5.672 0 Td (carbon )Tj 0.0079 Tc 3.361 0 Td (monoxide )Tj -0.0018 Tc 4.388 0 Td (diffusing )Tj 0.361 0.365 0.349 rg 0.0076 Tc 3.933 0 Td (capacity: )Tj 0.302 0.306 0.29 rg 0.0004 Tc 4.111 0 Td (Reference )Tj 0.361 0.365 0.349 rg 0.0154 Tc -23.428 -1.041 Td (equations )Tj 0.302 0.306 0.29 rg 0.0034 Tc 4.512 0 Td (derived )Tj 0.0014 Tc 3.584 0 Td (from )Tj 0.361 0.365 0.349 rg 0 Tc 2.546 0 Td (a )Tj 0.302 0.306 0.29 rg 0.0022 Tc 1.049 0 Td (healthy )Tj 0.0102 Tc 3.586 0 Td (nonsmoking )Tj 0.0273 Tc 5.612 0 Td (population )Tj 0.0069 Tc 5.078 0 Td (and )Tj 0.361 0.365 0.349 rg -0.0258 Tc -25.967 -1.099 Td (effects )Tj 0.05 Tc 8.9033 0 0 8.3 77.68 229.21 Tm (of )Tj 0.302 0.306 0.29 rg 0.011 Tc 8.3 0 0 8.3 87.83 229.21 Tm (hematocrit. )Tj /T1_2 1 Tf 0.0357 Tc 8.1 0 0 8.1 130.2 229.21 Tm (Am )Tj 0.0238 Tc 1.77 0 Td (Rev )Tj -0.0114 Tc 1.956 0 Td (Respir )Tj -0.0139 Tc 2.906 0 Td (Dis, )Tj 0.361 0.365 0.349 rg /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 200.84 229.21 Tm (1987, )Tj 0.302 0.306 0.29 rg 7.7728 0 0 8.3 221.49 229.21 Tm (135)Tj 0.451 0.455 0.439 rg 0 Tc 8.3 0 0 8.3 232.67 229.21 Tm (, )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf -0.0096 Tc 8.3 0 0 8.3 237.4508 229.21 Tm (805)Tj 0.714 0.718 0.702 rg 0 Tc 1.51 0 Td (-)Tj 0.302 0.306 0.29 rg -0.0126 Tc 0.514 0 Td (811. )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 7.7937 0 0 8.3 54.93 220.57 Tm (12. )Tj -0.0289 Tc 8.3 0 0 8.3 72.44 220.57 Tm (Lewis )Tj 0.204 0.208 0.196 rg 0 Tc 2.66 0 Td (B)Tj 0.302 0.306 0.29 rg -0.0297 Tc 0.636 0 Td (M, )Tj 0.0053 Tc 1.446 0 Td (Hayford-Wclsing )Tj 0.361 0.365 0.349 rg 0.0419 Tc 8 0 0 8 172.76 220.57 Tm (EJ, )Tj 0.302 0.306 0.29 rg 0.0077 Tc 8.3 0 0 8.3 186.2 220.57 Tm (McGinty )Tj 0.0175 Tc 3.931 0 Td (JD.)Tj 0.451 0.455 0.439 rg 0 Tc 1.671 0 Td (-)Tj 0.204 0.208 0.196 rg 0.813 0 Td (T)Tj 0.302 0.306 0.29 rg -0.0138 Tc 0.701 0 Td (he )Tj 0.361 0.365 0.349 rg -0.0109 Tc 1.147 0 Td (effect )Tj 0.302 0.306 0.29 rg 0.05 Tc 8.9033 0 0 8.3 275.43 220.57 Tm (of )Tj 0.007 Tc 8.3 0 0 8.3 309.13 743.29 Tm (bronchospasm )Tj 0.0035 Tc 6.177 0 Td (on )Tj 0.0036 Tc 1.399 0 Td (pulmonary-diffusing )Tj 0.361 0.365 0.349 rg 0.0152 Tc 8.606 0 Td (capacity)Tj 0.204 0.208 0.196 rg 0 Tc 3.517 0 Td (. )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_2 1 Tf -0.0171 Tc 8.1 0 0 8.1 476.96 743.29 Tm (Clin )Tj EMC ET BT /T1_2 1 Tf -0.0099 Tc 8.1 0 0 8.1 493.9781 743.29 Tm (Res, )Tj 0.361 0.365 0.349 rg /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 510.92 743.29 Tm (1959, )Tj -0.0314 Tc 8.3 0 0 8.3 530.79 743.29 Tm (7, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.2694 0 0 8.3 308.54 734.65 Tm (302)Tj 0.569 0.572 0.557 rg 0 Tc 8.3 0 0 8.3 320.54 734.65 Tm (-)Tj 0.361 0.365 0.349 rg -0.0313 Tc 0.578 0 Td (303. )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.7937 0 0 8.3 309.33 725.53 Tm (13. )Tj 0.0087 Tc 8.3 0 0 8.3 326.84 725.53 Tm (Mc)Tj 0.204 0.208 0.196 rg 0 Tc 1.388 0 Td (D)Tj 0.361 0.365 0.349 rg 0.05 Tc 8.4491 0 0 8.3 344.08 725.53 Tm (cnnott )Tj 0.302 0.306 0.29 rg -0.0297 Tc 8.3 0 0 8.3 374.36 725.53 Tm (M, )Tj 0.0187 Tc 1.966 0 Td (McDermott )Tj 0.0199 Tc 5.606 0 Td (TJ. )Tj 0.361 0.365 0.349 rg 0 Tc 2.078 0 Td (-)Tj 0.302 0.306 0.29 rg 0.0032 Tc 1.453 0 Td (Digital )Tj 0.361 0.365 0.349 rg 0.0103 Tc 3.64 0 Td (incremental )Tj 0.302 0.306 0.29 rg 0.0011 Tc -22.664 -1.041 Td (techniques )Tj 0.361 0.365 0.349 rg 0.0034 Tc 4.735 0 Td (applied )Tj 0.302 0.306 0.29 rg 0.035 Tc 3.477 0 Td (to )Tj 0.0073 Tc 1.26 0 Td (spirometry. )Tj /T1_2 1 Tf 0.0157 Tc 8.1 0 0 8.1 430.14 716.89 Tm (Pro)Tj 0.451 0.455 0.439 rg 0 Tc 1.526 0 Td (c )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_2 1 Tf 0.05 Tc 8.1452 0 0 8.1 449.82 716.89 Tm (Roy )Tj EMC ET BT /T1_2 1 Tf 0.0436 Tc 8.1 0 0 8.1 467.51 716.89 Tm (Soc )Tj 0.003 Tc 2.026 0 Td (Med, )Tj /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 505.64 716.89 Tm (1977, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0344 Tc 8.3 0 0 8.3 526.95 716.89 Tm (70, )Tj EMC /Suspect <>BDC 0.0023 Tc -26.222 -1.042 Td (169-171. )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 7.5202 0 0 8.3 309.34 699.12 Tm (14)Tj 0.071 0.074 0.059 rg 0 Tc 8.3 0 0 8.3 316.63 699.12 Tm (. )Tj 0.302 0.306 0.29 rg 0.0131 Tc 1.23 0 Td (Morris )Tj 0.0234 Tc 3.069 0 Td (AH, )Tj 0.031 Tc 2.074 0 Td (Crapo )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0082 Tc 8.3 0 0 8.3 393.5627 699.12 Tm (RO. )Tj EMC ET BT 0.569 0.572 0.557 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 410.3038 699.12 Tm (-)Tj 0.361 0.365 0.349 rg 0.0256 Tc 0.746 0 Td (Standardization )Tj 0.302 0.306 0.29 rg 0.05 Tc 8.9033 0 0 8.3 474.15 699.12 Tm (of )Tj 0.361 0.365 0.349 rg 0.0347 Tc 8.3 0 0 8.3 482.8 699.12 Tm (computation )Tj 0.05 Tc 8.9033 0 0 8.3 529.84 699.12 Tm (of )Tj 0.0061 Tc 8.3 0 0 8.3 308.04 690 Tm (single-breath )Tj 0.302 0.306 0.29 rg 0.0189 Tc 5.737 0 Td (transfer )Tj -0.0089 Tc 3.635 0 Td (factor. )Tj /T1_2 1 Tf 0.018 Tc 8.1 0 0 8.1 411.42 690 Tm (Bull )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_2 1 Tf 0.044 Tc 8.1 0 0 8.1 427.7415 690 Tm (Eur )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg -0.018 Tc 2.074 0 Td (Physz'opathol )Tj EMC ET BT /T1_2 1 Tf -0.0018 Tc 8.1 0 0 8.1 491.5776 690 Tm (Respir, )Tj /T1_0 1 Tf -0.0242 Tc 8.3 0 0 8.3 519.07 690 Tm (1985, )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf -0.0083 Tc 8.3 0 0 8.3 308.1089 681.3597 Tm (21, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.7728 0 0 8.3 321.81 681.36 Tm (183)Tj 0.569 0.572 0.557 rg 0 Tc 8.3 0 0 8.3 333.5 681.36 Tm (-)Tj 0.302 0.306 0.29 rg -0.035 Tc 7.7728 0 0 8.3 338.61 681.36 Tm (189)Tj 0.451 0.455 0.439 rg 0 Tc 8.3 0 0 8.3 349.75 681.36 Tm (. )Tj 0.361 0.365 0.349 rg -0.035 Tc 7.3607 0 0 8.3 309.35 672.24 Tm (15. )Tj 0.0019 Tc 8.3 0 0 8.3 326.44 672.24 Tm (Nie )Tj 0.302 0.306 0.29 rg 0.0204 Tc 1.851 0 Td (NH, )Tj 0.0093 Tc 2.13 0 Td (Hull )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0304 Tc 8.3 0 0 8.3 377.2028 672.24 Tm (CH, )Tj EMC ET BT /T1_0 1 Tf 0.0222 Tc 8.3 0 0 8.3 394.0352 672.24 Tm (Jenkins )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.7524 0 0 8.3 422.35 672.24 Tm (JC)Tj 0.451 0.455 0.439 rg 0 Tc 8.3 0 0 8.3 431.87 672.24 Tm (, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0227 Tc 8.3 0 0 8.3 436.6508 672.24 Tm (Steinbrenner )Tj 0.0133 Tc 5.681 0 Td (K, )Tj -0.0046 Tc 1.388 0 Td (Bent )Tj 0.0287 Tc 2.255 0 Td (DH. )Tj 0.361 0.365 0.349 rg 0 Tc 2.19 0 Td (-)Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_2 1 Tf -0.035 Tc 7.2371 0 0 8.1 308.71 663.61 Tm (In: )Tj EMC ET BT /T1_0 1 Tf 0.0031 Tc 8.3 0 0 8.3 321.45 663.61 Tm (Statistical )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0262 Tc 8.3 0 0 8.3 358.5178 663.61 Tm (Package )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf -0.0143 Tc 8.3 0 0 8.3 391.585 663.61 Tm (for )Tj -0.0016 Tc 1.743 0 Td (the )Tj -0.0065 Tc 1.719 0 Td (Social )Tj -0.0083 Tc 2.949 0 Td (Sciences. )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0032 Tc 8.3 0 0 8.3 479.8389 663.61 Tm (Second )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0252 Tc 8.3 0 0 8.3 508.2581 663.61 Tm (Edition. )Tj 0.302 0.306 0.29 rg 0.0096 Tc -24.057 -1.1 Td (McGraw-Hill, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0054 Tc 8.3 0 0 8.3 359.9786 654.48 Tm (U.S.A. )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.0056 0 0 8.3 386.6 654.48 Tm (1975. )Tj 0.204 0.208 0.196 rg 0 Tc 8.3 0 0 8.3 308.83 645.85 Tm (1)Tj 0.361 0.365 0.349 rg -0.0314 Tc 0.37 0 Td (6. )Tj 0.302 0.306 0.29 rg -0.0137 Tc 1.737 0 Td (Ogilvie )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0336 Tc 8.3 0 0 8.3 353.6749 645.85 Tm (CM, )Tj EMC ET BT /T1_0 1 Tf 0.0226 Tc 8.3 0 0 8.3 372.9143 645.85 Tm (Forster )Tj 0.0189 Tc 3.354 0 Td (RE, )Tj 0.0043 Tc 2.024 0 Td (Blakemore )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0037 Tc 8.3 0 0 8.3 457.4 645.85 Tm (WS, )Tj EMC ET BT /T1_0 1 Tf 0.0385 Tc 8.3 0 0 8.3 475.6268 645.85 Tm (Morton )Tj /T1_1 1 Tf 0.0291 Tc 8 0 0 8 505.38 645.85 Tm (JW)Tj 0.451 0.455 0.439 rg 0 Tc 1.481 0 Td (.)Tj 0.569 0.572 0.557 rg 0.617 0 Td (-)Tj 0.302 0.306 0.29 rg 1.03 0 Td (A )Tj 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0113 Tc 8.3 0 0 8.3 308.04 636.73 Tm (standardized )Tj 0.0202 Tc 5.51 0 Td (breathholding )Tj 0.302 0.306 0.29 rg 0.0065 Tc 6.069 0 Td (technique )Tj 0.0146 Tc 4.213 0 Td (for )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0273 Tc 8.3 0 0 8.3 451.6632 636.73 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0046 Tc 8.3 0 0 8.3 464.08 636.73 Tm (clinical )Tj 0.302 0.306 0.29 rg 0.0116 Tc 3.246 0 Td (measurement )Tj 0.361 0.365 0.349 rg 0.05 Tc 8.9033 0 0 8.3 308.08 627.61 Tm (of )Tj 0.302 0.306 0.29 rg -0.0016 Tc 8.3 0 0 8.3 318.22 627.61 Tm (the )Tj -0.0018 Tc 1.554 0 Td (diffusing )Tj 0.0152 Tc 3.875 0 Td (capacity )Tj 0.361 0.365 0.349 rg 0.05 Tc 8.9033 0 0 8.3 394.96 627.61 Tm (of )Tj 0.0273 Tc 8.3 0 0 8.3 404.62 627.61 Tm (the )Tj 0.302 0.306 0.29 rg -0.035 Tc 7.9257 0 0 8.3 418.49 627.61 Tm (lu)Tj 0.204 0.208 0.196 rg 0 Tc 8.3 0 0 8.3 424.79 627.61 Tm (n)Tj 0.361 0.365 0.349 rg 0.513 0 Td (g )Tj 0.302 0.306 0.29 rg 0.0146 Tc 0.865 0 Td (for )Tj 0.361 0.365 0.349 rg 0.0385 Tc 1.505 0 Td (carbon )Tj 0.302 0.306 0.29 rg 0.0118 Tc 3.304 0 Td (monoxide. )Tj /T1_3 1 Tf 0 Tc 7.4001 0 0 7.4001 514.97 627.61 Tm (J )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_2 1 Tf -0.0171 Tc 8.1 0 0 8.1 522.56 627.61 Tm (Clin )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_2 1 Tf 0.0099 Tc 8.1 0 0 8.1 307.7642 618.9673 Tm (Invest, )Tj /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 333.32 618.97 Tm (1957, )Tj 0.361 0.365 0.349 rg -0.0282 Tc 8.3 0 0 8.3 353.66 618.97 Tm (36, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0176 Tc 8.3 0 0 8.3 366.9068 618.97 Tm (1-17. )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.7937 0 0 8.3 308.85 609.85 Tm (17. )Tj 0.0199 Tc 8.3 0 0 8.3 326.32 609.85 Tm (Oldham )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0244 Tc 8.3 0 0 8.3 356.117 609.85 Tm (PD. )Tj EMC /Suspect <>BDC 0.361 0.365 0.349 rg /T1_2 1 Tf 0.05 Tc 9.4176 0 0 8.7 371.93 609.85 Tm (-In: )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0125 Tc 8.3 0 0 8.3 390.68 609.85 Tm (Measurement )Tj 0.0488 Tc 5.78 0 Td (in )Tj 0.0079 Tc 1.16 0 Td (Medicine)Tj 0.451 0.455 0.439 rg 0 Tc 3.796 0 Td (: )Tj 0.302 0.306 0.29 rg 0.0414 Tc 0.537 0 Td (The )Tj 0.0194 Tc 1.908 0 Td (interpreta\255)Tj 0.0033 Tc -23.126 -1.041 Td (tion )Tj 0.361 0.365 0.349 rg 0.05 Tc 8.9033 0 0 8.3 324.4 601.21 Tm (of )Tj 0.302 0.306 0.29 rg 0.0066 Tc 8.3 0 0 8.3 334.55 601.21 Tm (numerica)Tj 0.204 0.208 0.196 rg 0 Tc 3.81 0 Td (l )Tj 0.302 0.306 0.29 rg 0.0156 Tc 0.577 0 Td (data. )Tj -0.0055 Tc 2.433 0 Td (English )Tj 0.361 0.365 0.349 rg 0.0033 Tc 3.417 0 Td (Universities )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0053 Tc 8.3 0 0 8.3 462.6854 601.21 Tm (Press, )Tj EMC ET BT /T1_0 1 Tf 0.0204 Tc 8.3 0 0 8.3 485.7262 601.21 Tm (London. )Tj 0.361 0.365 0.349 rg -0.035 Tc 8.0056 0 0 8.3 519.08 601.21 Tm (1968. )Tj 0.302 0.306 0.29 rg 7.7937 0 0 8.3 308.85 592.09 Tm (18. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0043 Tc 8.3 0 0 8.3 326.36 592.09 Tm (Paoletti )Tj EMC /Suspect <>BDC 0.204 0.208 0.196 rg 0 Tc 8 0 0 8 355.17 592.09 Tm (P)Tj 0.302 0.306 0.29 rg 0.589 0 Td (, )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.1067 0 0 8.3 364.78 592.09 Tm (Viegi )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0262 Tc 8.3 0 0 8.3 384.88 592.09 Tm (G, )Tj EMC /Suspect <>BDC -0.0139 Tc 1.335 0 Td (Pistelli )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 0.05 Tc 8.011 0 0 8 421.89 592.09 Tm (F, )Tj 0.302 0.306 0.29 rg 0.0007 Tc 8.3 0 0 8.3 431.48 592.09 Tm (Di )Tj -0.0061 Tc 1.388 0 Td (Pede )Tj 0.05 Tc 8.011 0 0 8 462.21 592.09 Tm (F, )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0132 Tc 8.3 0 0 8.3 471.8 592.09 Tm (Fazzi )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg -0.035 Tc 8.2578 0 0 8.3 493.4 592.09 Tm (P, )Tj EMC ET BT /T1_0 1 Tf 0.0245 Tc 8.3 0 0 8.3 503 592.09 Tm (Polato )Tj 0.05 Tc 8.4674 0 0 8.3 527.96 592.09 Tm (R, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0165 Tc 8.3 0 0 8.3 308.01 583.44 Tm (Saetta )Tj EMC /Suspect <>BDC -0.0297 Tc 3.252 0 Td (M, )Tj EMC ET BT /T1_0 1 Tf 0.0189 Tc 8.3 0 0 8.3 349.8918 583.44 Tm (Zambon )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 384.4447 583.44 Tm (R)Tj 0.451 0.455 0.439 rg 0.683 0 Td (, )Tj EMC /Suspect <>BDC 0.302 0.306 0.29 rg -0.002 Tc 0.931 0 Td (Carli )Tj EMC ET BT /T1_0 1 Tf 0.0262 Tc 8.3 0 0 8.3 420.4003 583.44 Tm (G, )Tj 0.0139 Tc 1.677 0 Td (Giuntini )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 468.8806 583.44 Tm (C)Tj 0.451 0.455 0.439 rg 0.688 0 Td (, )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf -0.0001 Tc 8.3 0 0 8.3 482.8412 583.44 Tm (Lebowitz )Tj 0.302 0.306 0.29 rg 0.05 Tc 8.4341 0 0 8.3 519.8 583.44 Tm (MD)Tj 0.451 0.455 0.439 rg 0 Tc 8.3 0 0 8.3 534.11 583.44 Tm (, )Tj 0.302 0.306 0.29 rg 0.025 Tc -27.228 -1.098 Td (Knudson )Tj -0.0152 Tc 4.106 0 Td (RJ. )Tj 0.361 0.365 0.349 rg 0 Tc 1.67 0 Td (-)Tj 0.204 0.208 0.196 rg 0.875 0 Td (R)Tj 0.361 0.365 0.349 rg -0.0093 Tc 0.688 0 Td (eference )Tj 0.0226 Tc 3.586 0 Td (equations )Tj 0.302 0.306 0.29 rg -0.0143 Tc 4.337 0 Td (for )Tj 0.0273 Tc 1.454 0 Td (the )Tj 0.0021 Tc 1.549 0 Td (single)Tj 0.204 0.208 0.196 rg 0 Tc 2.374 0 Td (-)Tj 0.302 0.306 0.29 rg 0.0116 Tc 0.36 0 Td (breath )Tj -0.0018 Tc 2.881 0 Td (diffusing )Tj 0.0037 Tc -23.942 -1.042 Td (capacity. )Tj 0.361 0.365 0.349 rg /T1_3 1 Tf 0.05 Tc 7.4801 0 0 7.1 340.85 565.68 Tm (Am )Tj 0.302 0.306 0.29 rg /T1_2 1 Tf -0.0058 Tc 8.1 0 0 8.1 356.22 565.68 Tm (Rev )Tj 0.0005 Tc 1.896 0 Td (Respir )Tj -0.0139 Tc 2.906 0 Td (Dis, )Tj 0.361 0.365 0.349 rg /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 412.04 565.68 Tm (1985, )Tj 0.302 0.306 0.29 rg 7.7728 0 0 8.3 432.69 565.68 Tm (132)Tj 0.451 0.455 0.439 rg 0 Tc 8.3 0 0 8.3 444.35 565.68 Tm (, )Tj 0.361 0.365 0.349 rg 0.0219 Tc 0.518 0 Td (806-813. )Tj -0.035 Tc 7.7937 0 0 8.3 308.37 556.56 Tm (19. )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0001 Tc 8.3 0 0 8.3 325.88 556.56 Tm (Piiper )Tj EMC /Suspect <>BDC 0.0053 Tc 2.775 0 Td (J, )Tj EMC /Suspect <>BDC 0.0185 Tc 1.087 0 Td (Sikand )Tj EMC /Suspect <>BDC -0.0052 Tc 3.31 0 Td (RS)Tj 0.451 0.455 0.439 rg 0 Tc 1.257 0 Td (. )Tj EMC ET BT 0.569 0.572 0.557 rg /T1_0 1 Tf 8.3 0 0 8.3 400.7128 556.56 Tm (-)Tj 0.302 0.306 0.29 rg 0.0218 Tc 0.99 0 Td (Determination )Tj 0.361 0.365 0.349 rg 0.05 Tc 8.9033 0 0 8.3 462.15 556.56 Tm (of )Tj 0.302 0.306 0.29 rg 8.785 0 0 8.3 472.76 556.56 Tm (Dco )Tj -0.035 Tc 8.0386 0 0 8.3 491.53 556.56 Tm (by )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0273 Tc 8.3 0 0 8.3 503.02 556.56 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0021 Tc 8.3 0 0 8.3 516.3581 556.56 Tm (single )Tj 0.361 0.365 0.349 rg 0.0116 Tc -25.083 -1.099 Td (breath )Tj 0.302 0.306 0.29 rg 0.0261 Tc 3.119 0 Td (method )Tj -0.009 Tc 3.695 0 Td (in )Tj 0.0137 Tc 1.33 0 Td (inhomogeneous )Tj 0.361 0.365 0.349 rg -0.0113 Tc 7.055 0 Td (lungs; )Tj 0.302 0.306 0.29 rg 0.0055 Tc 3.013 0 Td (theory. )Tj /T1_2 1 Tf 0.0253 Tc 8.1 0 0 8.1 488.22 547.44 Tm (Resp )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0184 Tc 8.1 0 0 8.1 509.3367 547.44 Tm (Phy)Tj 0.451 0.455 0.439 rg 0 Tc 1.596 0 Td (s)Tj 0.302 0.306 0.29 rg 0.0433 Tc 0.399 0 Td (ic/)Tj 0.451 0.455 0.439 rg 0 Tc 1.083 0 Td (, )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf -0.035 Tc 8.241 0 0 8.3 308.36 538.8 Tm (1966, )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 9.6149 0 0 8.2 329.02 538.8 Tm (I, )Tj EMC ET BT /T1_0 1 Tf -0.0344 Tc 8.3 0 0 8.3 337.35 538.8 Tm (75. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.2681 0 0 8.3 307.63 529.68 Tm (20. )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0167 Tc 8.3 0 0 8.3 325.84 529.68 Tm (Quanjer )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.044 Tc 8.3 0 0 8.3 358.044 529.68 Tm (PhH )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf -0.0118 Tc 8.3 0 0 8.3 378.628 529.68 Tm (\(ed\). )Tj 0.569 0.572 0.557 rg 0 Tc 2.429 0 Td (-)Tj 0.302 0.306 0.29 rg 0.0232 Tc 1.093 0 Td (Standardized )Tj 0.0103 Tc 6.024 0 Td (lung )Tj 0.361 0.365 0.349 rg 0.0007 Tc 2.427 0 Td (function )Tj 0.302 0.306 0.29 rg 0.0055 Tc 3.999 0 Td (testing. )Tj 0.0146 Tc -24.526 -1.04 Td (Transfer )Tj 0.0046 Tc 3.93 0 Td (factor )Tj 0.361 0.365 0.349 rg -0.0054 Tc 2.775 0 Td (\(diffusing )Tj 0.0113 Tc 4.224 0 Td (capacity\). )Tj 0.302 0.306 0.29 rg 0.0234 Tc 4.516 0 Td (Report )Tj 0.361 0.365 0.349 rg 0.05 Tc 9.4598 0 0 8.3 462.63 521.05 Tm (of )Tj 0.302 0.306 0.29 rg 0.0162 Tc 8.3 0 0 8.3 473.25 521.05 Tm (Working )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0404 Tc 8.3 0 0 8.3 506.8401 521.05 Tm (Party )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 0.05 Tc 8.9033 0 0 8.3 528.88 521.05 Tm (of )Tj 0.302 0.306 0.29 rg -0.0305 Tc 8.3 0 0 8.3 308.14 511.92 Tm (the )Tj 0.0166 Tc 1.616 0 Td (European )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0204 Tc 8.3 0 0 8.3 357.525 511.92 Tm (Community )Tj EMC ET BT /T1_0 1 Tf 0.0146 Tc 8.3 0 0 8.3 402.1541 511.92 Tm (for )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0147 Tc 8.3 0 0 8.3 415.127 511.92 Tm (Coal )Tj EMC ET BT /T1_0 1 Tf 0.0358 Tc 8.3 0 0 8.3 434.3249 511.92 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0088 Tc 8.3 0 0 8.3 450.0949 511.92 Tm (Steel, )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0151 Tc 8.3 0 0 8.3 472.2891 511.92 Tm (Luxembourg, )Tj 0.0257 Tc 5.898 0 Td (July )Tj 0.361 0.365 0.349 rg -0.035 Tc 8.0056 0 0 8.3 308.36 503.28 Tm (1983. )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_2 1 Tf 0.018 Tc 8.1 0 0 8.1 328.38 503.28 Tm (Bull )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_2 1 Tf 0.0144 Tc 8.1 0 0 8.1 344.7015 503.28 Tm (Eur )Tj 0.0045 Tc 1.896 0 Td (Physiopotho/ )Tj 0.302 0.306 0.29 rg 0.0005 Tc 5.689 0 Td (Respir)Tj 0.451 0.455 0.439 rg 0 Tc 2.663 0 Td (, )Tj 0.204 0.208 0.196 rg /T1_0 1 Tf 8.3 0 0 8.3 432.67 503.28 Tm (1)Tj 0.361 0.365 0.349 rg -0.016 Tc 0.429 0 Td (983, )Tj 0.302 0.306 0.29 rg -0.0115 Tc 2.116 0 Td (19\(suppl. )Tj 0.361 0.365 0.349 rg 0.0124 Tc 7.6 0 0 7.6 487.58 503.28 Tm (5\), )Tj 0.0228 Tc 8.3 0 0 8.3 499.1 503.28 Tm (39-44. )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0112 Tc 8.3 0 0 8.3 308.117 488.4064 Tm (RESUME: )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0002 Tc 8.3 0 0 8.3 349.3929 488.4064 Tm (Le )Tj 0.302 0.306 0.29 rg 0.0071 Tc 1.555 0 Td (facteur )Tj 0.0491 Tc 3.298 0 Td (de )Tj 0.0038 Tc 1.511 0 Td (transfer! )Tj 0.361 0.365 0.349 rg 0.0046 Tc 3.925 0 Td (calcule )Tj 0.302 0.306 0.29 rg 0.014 Tc 3.292 0 Td (selon )Tj -0.0151 Tc 2.642 0 Td (!a )Tj 0.0154 Tc 1.245 0 Td (methode )Tj 0.361 0.365 0.349 rg 0.0021 Tc 3.982 0 Td (en )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0012 Tc 8.3 0 0 8.3 307.5941 479.7578 Tm (apnee )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0088 Tc 8.3 0 0 8.3 331.5728 479.7578 Tm (\(TL\), )Tj -0.035 Tc 7.8836 0 0 8.3 353.69 479.76 Tm (le )Tj 0.361 0.365 0.349 rg 0.0031 Tc 8.3 0 0 8.3 363.82 479.76 Tm (volume )Tj 0.0114 Tc 3.463 0 Td (alveo)Tj 0.204 0.208 0.196 rg 0 Tc 2.199 0 Td (l)Tj 0.302 0.306 0.29 rg 0.0062 Tc 0.288 0 Td (airc )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.026 Tc 8.3 0 0 8.3 429.9959 479.76 Tm (etaot )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0268 Tc 8.3 0 0 8.3 451.6091 479.76 Tm (obtenu )Tj 0.0316 Tc 3.423 0 Td (par )Tj 0.0179 Tc 1.848 0 Td (respirations )Tj 0.0113 Tc -22.613 -1.098 Td (multip)Tj 0.204 0.208 0.196 rg 0 Tc 2.712 0 Td (l)Tj 0.361 0.365 0.349 rg -0.035 Tc 8.2238 0 0 8.3 332.07 470.65 Tm (es, )Tj 0.302 0.306 0.29 rg 0 Tc 8.3 0 0 8.3 342.64 470.65 Tm (a )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0358 Tc 8.3 0 0 8.3 348.4002 470.65 Tm (cte )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0022 Tc 8.3 0 0 8.3 360.4601 470.65 Tm (mesure )Tj 0.044 Tc 3.181 0 Td (thez )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.002 Tc 8.3 0 0 8.3 403.6284 470.65 Tm (20 )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0144 Tc 8.3 0 0 8.3 413.7378 470.65 Tm (malades )Tj 0.0268 Tc 3.589 0 Td (presentant )Tj 0.0306 Tc 4.625 0 Td (une )Tj 0.0209 Tc 1.725 0 Td (obstruction )Tj 0.361 0.365 0.349 rg -0.007 Tc -22.719 -1.042 Td (reversible )Tj 0.302 0.306 0.29 rg 0.0036 Tc 4.155 0 Td (des )Tj -0.0199 Tc 1.684 0 Td (voies )Tj -0.0001 Tc 2.364 0 Td (aeriennes )Tj 0.0304 Tc 4.106 0 Td (avan)Tj 0.204 0.208 0.196 rg 0 Tc 1.974 0 Td (t )Tj 0.361 0.365 0.349 rg 0.05 Tc 8.3173 0 0 8.3 431.43 462 Tm (et )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0252 Tc 8.3 0 0 8.3 440.08 462 Tm (apres )Tj EMC ET BT /T1_0 1 Tf 0.0192 Tc 8.3 0 0 8.3 460.6806 462 Tm (salbutamol. )Tj /T1_1 1 Tf 0.05 Tc 8.0504 0 0 8 503.83 462 Tm (Lc )Tj /T1_0 1 Tf -0.0031 Tc 8.3 0 0 8.3 515.5 462 Tm (temps )Tj 0.0301 Tc -25.106 -1.098 Td (d'apnee )Tj -0.0148 Tc 3.584 0 Td (effective )Tj 0.361 0.365 0.349 rg 0 Tc 3.818 0 Td (a )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0067 Tc 8.3 0 0 8.3 376.226 452.8866 Tm (etc )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0046 Tc 8.3 0 0 8.3 389.672 452.8866 Tm (calcule )Tj 0.302 0.306 0.29 rg -0.0087 Tc 3.239 0 Td (de )Tj 0.0349 Tc 1.388 0 Td (quatre )Tj 0.0061 Tc 3.13 0 Td (maniercs )Tj -0.0078 Tc 4.099 0 Td (differentes; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8.3 529.39 452.89 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0057 Tc 8.3 0 0 8.3 307.66 444.25 Tm (methode )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0214 Tc 8.3 0 0 8.3 338.3202 444.25 Tm (d'Ogi)Tj 0.204 0.208 0.196 rg 0 Tc 2.372 0 Td (l)Tj 0.302 0.306 0.29 rg -0.0289 Tc 0.237 0 Td (vie )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 0.05 Tc 8.9571 0 0 8.3 370.95 444.25 Tm (el )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0104 Tc 8.3 0 0 8.3 379.12 444.25 Tm (coil )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0055 Tc 8.3 0 0 8.3 393.5786 444.25 Tm (moditiee )Tj 0.302 0.306 0.29 rg 0.05 Tc 8.4273 0 0 8.3 424.81 444.25 Tm (par )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.2885 0 0 8.3 438.66 444.25 Tm (I' )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 443.03 444.25 Tm (American )Tj 0.361 0.365 0.349 rg 0.0241 Tc 4.214 0 Td (Thoracic )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.002 Tc 8.3 0 0 8.3 510.5671 444.25 Tm (Society )Tj EMC /Suspect <>BDC 0.361 0.365 0.349 rg -0.035 Tc 8.1511 0 0 8.3 307.1 435.12 Tm (\(A)Tj 0.204 0.208 0.196 rg 0 Tc 8.3 0 0 8.3 315.77 435.12 Tm (T)Tj 0.361 0.365 0.349 rg -0.0317 Tc 0.684 0 Td (S\), )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0108 Tc 8.3 0 0 8.3 334.9679 435.12 Tm (le )Tj 0.361 0.365 0.349 rg 0.01 Tc 1.224 0 Td (projet )Tj 0.302 0.306 0.29 rg 0.0491 Tc 2.881 0 Td (de )Tj 0.361 0.365 0.349 rg 0.0201 Tc 1.499 0 Td (standardisation )Tj 0.0021 Tc 6.886 0 Td (en )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0074 Tc 8.3 0 0 8.3 450.6367 435.12 Tm (epidemiologic )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0087 Tc 8.3 0 0 8.3 502.9682 435.12 Tm (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 514.9866 435.12 Tm (I)Tj 0.451 0.455 0.439 rg 0.286 0 Td (')Tj 0.302 0.306 0.29 rg 0.0131 Tc 0.241 0 Td (ATS )Tj EMC /Suspect <>BDC 0.361 0.365 0.349 rg -0.0018 Tc -25.572 -1.099 Td (\(ATS\), )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0151 Tc 8.3 0 0 8.3 333.3411 425.9983 Tm (!a )Tj 0.0154 Tc 1.013 0 Td (methode )Tj 0.0491 Tc 3.81 0 Td (de )Tj 0.361 0.365 0.349 rg 0.0106 Tc 1.276 0 Td (Jones )Tj 0.05 Tc 8.9571 0 0 8.3 405.03 426 Tm (et )Tj 0.302 0.306 0.29 rg 0.0171 Tc 8.3 0 0 8.3 414.2 426 Tm (Meade )Tj 0.0226 Tc 3.129 0 Td (prenant )Tj 0.0021 Tc 3.458 0 Td (en )Tj 0.0175 Tc 1.274 0 Td (compte )Tj -0.035 Tc 7.8836 0 0 8.3 507.29 426 Tm (le )Tj 0.0113 Tc 8.3 0 0 8.3 515.02 426 Tm (temps )Tj -0.0087 Tc -25.048 -1.04 Td (de )Tj 0.361 0.365 0.349 rg -0.0189 Tc 1.339 0 Td (recueil )Tj 0.0491 Tc 2.941 0 Td (de )Tj 0.302 0.306 0.29 rg 0.0127 Tc 1.331 0 Td (l'echantillon )Tj 0.361 0.365 0.349 rg 0.05 Tc 8.3173 0 0 8.3 398.31 417.37 Tm (et )Tj 0.0017 Tc 8.3 0 0 8.3 407.52 417.37 Tm (une )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.025 Tc 8.3 0 0 8.3 422.38 417.37 Tm (methode )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf -0.0103 Tc 8.3 0 0 8.3 454.4429 417.37 Tm (simplifiee )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.3916 0 0 8.3 489.52 417.37 Tm (ou )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.6365 0 0 8.3 501.06 417.37 Tm (il )Tj 0.361 0.365 0.349 rg 0.0048 Tc 8.3 0 0 8.3 508.23 417.37 Tm (est )Tj 0.302 0.306 0.29 rg 0.025 Tc 1.454 0 Td (tenu )Tj 0.361 0.365 0.349 rg 0.0175 Tc -25.684 -1.099 Td (compte )Tj 0.302 0.306 0.29 rg 0.0491 Tc 3.354 0 Td (de )Tj 0.361 0.365 0.349 rg 0.0103 Tc 1.389 0 Td (l'echantillonage )Tj 0.05 Tc 8.3844 0 0 8.3 402.63 408.25 Tm (en )Tj 0.302 0.306 0.29 rg 0.0382 Tc 8.3 0 0 8.3 414.22 408.25 Tm (tenne )Tj 0.0491 Tc 2.653 0 Td (de )Tj 0.361 0.365 0.349 rg 0.0031 Tc 1.395 0 Td (volume )Tj 0.05 Tc 8.3173 0 0 8.3 476.07 408.25 Tm (et )Tj 0.302 0.306 0.29 rg 0.0035 Tc 8.3 0 0 8.3 485.75 408.25 Tm (non )Tj 0.0491 Tc 1.9 0 Td (de )Tj 0.361 0.365 0.349 rg -0.0062 Tc 1.395 0 Td (temps. )Tj 0.302 0.306 0.29 rg -0.0029 Tc -24.754 -1.1 Td (Deux )Tj 0.0202 Tc 2.84 0 Td (patients )Tj 0.0465 Tc 3.93 0 Td (n'ont )Tj -0.0079 Tc 2.836 0 Td (pu )Tj 0.361 0.365 0.349 rg 0.0017 Tc 1.733 0 Td (realiser )Tj -0.035 Tc 7.9707 0 0 8.3 431.93 399.12 Tm (les )Tj -0.0094 Tc 8.3 0 0 8.3 446.38 399.12 Tm (tests )Tj 0.302 0.306 0.29 rg 0.0171 Tc 2.422 0 Td (demandes )Tj 0.361 0.365 0.349 rg 0.0357 Tc 4.742 0 Td (qu'apres )Tj 0.0134 Tc -23.947 -1.099 Td (salbutamol. )Tj 0.302 0.306 0.29 rg 0.05 Tc 8.3019 0 0 8.3 348.92 390 Tm (Pour )Tj 0.361 0.365 0.349 rg -0.035 Tc 7.9707 0 0 8.3 368.09 390 Tm (les )Tj 0.0127 Tc 8.3 0 0 8.3 378.12 390 Tm (sujets )Tj 0.0186 Tc 2.558 0 Td (restants )Tj 0.0471 Tc 3.347 0 Td (le )Tj 0.0167 Tc 0.981 0 Td (facteur )Tj 0.302 0.306 0.29 rg 0.0491 Tc 3.066 0 Td (de )Tj 0.0038 Tc 1.28 0 Td (transfer! )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0119 Tc 8.3 0 0 8.3 502.0058 390 Tm (calculi: )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0021 Tc 8.3 0 0 8.3 526.9556 390 Tm (en )Tj 0.302 0.306 0.29 rg 0.0172 Tc -26.476 -1.04 Td (utilisant )Tj -0.035 Tc 7.8836 0 0 8.3 338.81 381.37 Tm (le )Tj 0.0031 Tc 8.3 0 0 8.3 347.98 381.37 Tm (volume )Tj 0.361 0.365 0.349 rg 0.0073 Tc 3.463 0 Td (alveolairc )Tj 0.0268 Tc 4.395 0 Td (obtcnu )Tj -0.0066 Tc 3.354 0 Td (au )Tj 0.0276 Tc 1.446 0 Td (cours )Tj 0.302 0.306 0.29 rg 0 Tc 2.66 0 Td (d)Tj 0.451 0.455 0.439 rg 0.635 0 Td (')Tj 0.302 0.306 0.29 rg 0.0017 Tc 0.242 0 Td (une )Tj 0.204 0.208 0.196 rg 0 Tc 1.9 0 Td (i)Tj 0.302 0.306 0.29 rg 0.0011 Tc 0.296 0 Td (nsp)Tj 0.204 0.208 0.196 rg 0 Tc 1.381 0 Td (i)Tj 0.302 0.306 0.29 rg 0.0198 Tc 0.296 0 Td (ration )Tj 0.0113 Tc -24.982 -1.099 Td (unique )Tj 0.361 0.365 0.349 rg 0.0087 Tc 3.111 0 Td (\(TL'\) )Tj 0.0048 Tc 2.488 0 Td (est )Tj 0.302 0.306 0.29 rg 0.0021 Tc 1.446 0 Td (en )Tj 0.0071 Tc 1.281 0 Td (moyenne )Tj -0.0133 Tc 4.189 0 Td (12% )Tj 0.0067 Tc 2.176 0 Td (plus )Tj 0.0069 Tc 2.024 0 Td (petit )Tj 0.361 0.365 0.349 rg 0.0354 Tc 2.187 0 Td (que )Tj 0.302 0.306 0.29 rg 0.025 Tc 1.794 0 Td (TL. )Tj 0.0371 Tc 1.97 0 Td (Kco, )Tj 0.05 Tc 8.8071 0 0 8.3 514.97 372.25 Tm (TL )Tj 0.361 0.365 0.349 rg 8.3173 0 0 8.3 528.87 372.25 Tm (et )Tj 0.204 0.208 0.196 rg 0 Tc 8.3 0 0 8.3 306.65 363.61 Tm (T)Tj 0.302 0.306 0.29 rg 0.0066 Tc 0.698 0 Td (L', )Tj 0.0314 Tc 1.32 0 Td (sont )Tj 0.204 0.208 0.196 rg 0 Tc 2.03 0 Td (l)Tj 0.302 0.306 0.29 rg -0.0026 Tc 0.171 0 Td (es )Tj 0.0067 Tc 1.053 0 Td (plus )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0208 Tc 8.3 0 0 8.3 366.1444 363.61 Tm (eleves )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.4273 0 0 8.3 387.85 363.61 Tm (par )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8.3 401.23 363.61 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0154 Tc 8.3 0 0 8.3 409.42 363.61 Tm (methode )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf -0.016 Tc 8.3 0 0 8.3 441.0679 363.61 Tm (ESP )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.3173 0 0 8.3 456.87 363.61 Tm (et )Tj 0.302 0.306 0.29 rg -0.035 Tc 7.9707 0 0 8.3 465.53 363.61 Tm (les )Tj -0.0126 Tc 8.3 0 0 8.3 476.17 363.61 Tm (plus )Tj -0.0131 Tc 1.896 0 Td (faibles )Tj 0.05 Tc 8.4273 0 0 8.3 515.53 363.61 Tm (par )Tj -0.035 Tc 7.9307 0 0 8.3 528.91 363.61 Tm (Ia )Tj 0.0154 Tc 8.3 0 0 8.3 307.18 354.49 Tm (methode )Tj 0.361 0.365 0.349 rg -0.0227 Tc 3.752 0 Td (Ogilvie. )Tj 0.302 0.306 0.29 rg 0 Tc 3.417 0 Td (L)Tj 0.451 0.455 0.439 rg 0.63 0 Td (')Tj 0.204 0.208 0.196 rg 0.234 0 Td (i)Tj 0.302 0.306 0.29 rg 0.0129 Tc 0.296 0 Td (nhalation )Tj 0.0491 Tc 4.098 0 Td (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.1639 0 0 8.3 420.43 354.49 Tm (200 )Tj EMC ET BT /T1_0 1 Tf -0.0192 Tc 8.3 0 0 8.3 434.38 354.49 Tm (meg )Tj -0.0087 Tc 1.901 0 Td (de )Tj 0.361 0.365 0.349 rg 0.0234 Tc 1.152 0 Td (salbutamol )Tj 0.302 0.306 0.29 rg -0.035 Tc 7.9585 0 0 8.3 500.15 354.49 Tm (ne )Tj 0.0108 Tc 8.3 0 0 8.3 509.26 354.49 Tm (modi )Tj -0.035 Tc 7.6632 0 0 8.3 527.44 354.49 Tm (fie )Tj 0.0036 Tc 8.3 0 0 8.3 307.21 345.37 Tm (pas )Tj 0.361 0.365 0.349 rg 0.0338 Tc 1.61 0 Td (TL', )Tj 0.302 0.306 0.29 rg -0.0002 Tc 2.081 0 Td (quelle )Tj 0.0354 Tc 2.718 0 Td (que )Tj 0.0286 Tc 1.788 0 Td (soil )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.2698 0 0 8.3 390.67 345.37 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0154 Tc 8.3 0 0 8.3 398.86 345.37 Tm (methode )Tj -0.007 Tc 3.877 0 Td (utilisee)Tj 0.451 0.455 0.439 rg 0 Tc 2.876 0 Td (, )Tj 0.302 0.306 0.29 rg -0.0219 Tc 0.535 0 Td (ni )Tj 0.204 0.208 0.196 rg 0 Tc 1.092 0 Td (T)Tj 0.302 0.306 0.29 rg 0.698 0 Td (L )Tj 0.05 Tc 8.3173 0 0 8.3 481.35 345.37 Tm (et )Tj 8.4409 0 0 8.3 490.52 345.37 Tm (Kco )Tj 0.025 Tc 8.3 0 0 8.3 507.76 345.37 Tm (obtcnus )Tj 0.361 0.365 0.349 rg 0.0029 Tc -24.236 -1.042 Td (se)Tj 0.204 0.208 0.196 rg 0 Tc 0.822 0 Td (t)Tj 0.361 0.365 0.349 rg 0.0035 Tc 0.282 0 Td (on )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.2698 0 0 8.3 328.27 336.72 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0154 Tc 8.3 0 0 8.3 337.9 336.72 Tm (methode )Tj -0.0087 Tc 3.925 0 Td (de )Tj 0.0106 Tc 1.392 0 Td (Jones )Tj 0.361 0.365 0.349 rg -0.0063 Tc 2.713 0 Td (et )Tj 0.302 0.306 0.29 rg -0.0016 Tc 1.22 0 Td (Meade, )Tj 0.361 0.365 0.349 rg 0.0116 Tc 3.466 0 Td (landis )Tj 0.302 0.306 0.29 rg 0.0354 Tc 2.89 0 Td (que )Tj -0.0084 Tc 1.908 0 Td (avec )Tj 0.361 0.365 0.349 rg -0.035 Tc 7.9707 0 0 8.3 502.01 336.72 Tm (les )Tj 0.302 0.306 0.29 rg 0.0341 Tc 8.3 0 0 8.3 514 336.72 Tm (autres )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0072 Tc 8.3 0 0 8.3 307.1806 327.6066 Tm (methodes )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0264 Tc 8.3 0 0 8.3 341.692 327.6066 Tm (les )Tj 0.0105 Tc 1.337 0 Td (resultats )Tj 0.0491 Tc 3.693 0 Td (de )Tj 0.05 Tc 8.8071 0 0 8.3 393.53 327.61 Tm (TL )Tj 0.361 0.365 0.349 rg 8.3173 0 0 8.3 406.47 327.61 Tm (et )Tj 0.302 0.306 0.29 rg 8.4409 0 0 8.3 415.64 327.61 Tm (Kco )Tj 8.3094 0 0 8.3 432.84 327.61 Tm (sont )Tj 0.0055 Tc 8.3 0 0 8.3 450.23 327.61 Tm (reduits. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.3019 0 0 8.3 478.04 327.61 Tm (Pour )Tj EMC /Suspect <>BDC -0.035 Tc 7.2698 0 0 8.3 497.23 327.61 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.025 Tc 8.3 0 0 8.3 505.42 327.61 Tm (methode )Tj 0.0043 Tc -23.949 -1.041 Td (d'Ogilvie )Tj -0.0113 Tc 4.171 0 Td (modifieela )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0055 Tc 8.3 0 0 8.3 379.675 318.9697 Tm (reduction )Tj EMC ET BT /T1_0 1 Tf 0.0261 Tc 8.3 0 0 8.3 415.1824 318.9697 Tm (vaut )Tj 0.361 0.365 0.349 rg 0.0187 Tc 2.246 0 Td (3.9%. )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0138 Tc 8.3 0 0 8.3 457.363 318.9697 Tm (Cette )Tj EMC /Suspect <>BDC 0.361 0.365 0.349 rg 0.0243 Tc 2.543 0 Td (erreur )Tj EMC ET BT /T1_0 1 Tf 0.0048 Tc 8.3 0 0 8.3 502.4735 318.9697 Tm (est )Tj 0.302 0.306 0.29 rg 0.0348 Tc 1.505 0 Td (due )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_1 1 Tf 0 Tc 11.1 0 0 11.1 530.76 318.97 Tm (a )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0017 Tc 8.3 0 0 8.3 307.2 309.84 Tm (une )Tj 0.361 0.365 0.349 rg 0.0114 Tc 1.72 0 Td (surestimation )Tj 0.302 0.306 0.29 rg 0.05 Tc 5.846 0 Td (du )Tj -0.0031 Tc 1.395 0 Td (temps )Tj 0.361 0.365 0.349 rg 0.0301 Tc 2.653 0 Td (d'apnee )Tj -0.0152 Tc 3.469 0 Td (effective, )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8.3 465.07 309.84 Tm (Ia )Tj EMC /Suspect <>BDC 0.0128 Tc 8.3 0 0 8.3 473.75 309.84 Tm (reduction )Tj EMC ET BT /T1_0 1 Tf 0.0491 Tc 8.3 0 0 8.3 508.2367 309.84 Tm (de )Tj 0.361 0.365 0.349 rg 0.0273 Tc 1.27 0 Td (39% )Tj 0.302 0.306 0.29 rg -0.0079 Tc -25.559 -1.099 Td (du )Tj 0.361 0.365 0.349 rg -0.0031 Tc 1.395 0 Td (temps )Tj 0.0143 Tc 2.653 0 Td (d'echantillonagc )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.026 Tc 8.3 0 0 8.3 398.303 300.7183 Tm (etant )Tj EMC /Suspect <>BDC 0.361 0.365 0.349 rg -0.0202 Tc 2.381 0 Td (negligee )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 445.2644 300.7183 Tm (.)Tj 0.784 0.784 0.773 rg 0.463 0 Td (. )Tj 0.361 0.365 0.349 rg /T1_1 1 Tf -0.0195 Tc 7.7 0 0 7.7 450.08 300.72 Tm (Le )Tj 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0113 Tc 8.3 0 0 8.3 460.78 300.72 Tm (temps )Tj 0.361 0.365 0.349 rg 0.0491 Tc 2.653 0 Td (de )Tj 0.302 0.306 0.29 rg 0.0116 Tc 1.307 0 Td (!'inspiration )Tj 0.0162 Tc -22.523 -1.04 Td (n'est )Tj 0.361 0.365 0.349 rg 0.0036 Tc 2.2 0 Td (pas )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0281 Tc 8.3 0 0 8.3 337.8404 292.088 Tm (change )Tj EMC ET BT /T1_0 1 Tf 0.0232 Tc 8.3 0 0 8.3 364.251 292.088 Tm (landis )Tj 0.0354 Tc 2.717 0 Td (que )Tj -0.035 Tc 7.8836 0 0 8.3 401.69 292.09 Tm (le )Tj 0.361 0.365 0.349 rg -0.0031 Tc 8.3 0 0 8.3 409.42 292.09 Tm (temps )Tj 0.0491 Tc 2.595 0 Td (de )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.035 Tc 7.9206 0 0 8.3 441.59 292.09 Tm (rin<;age )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0491 Tc 8.3 0 0 8.3 467.92 292.09 Tm (de )Tj 0.0029 Tc 1.273 0 Td (l'espace )Tj 0.0279 Tc 3.418 0 Td (mort )Tj 0.0337 Tc 2.189 0 Td (est )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf 0.0198 Tc 8.3 0 0 8.3 306.7008 282.9683 Tm (reduit )Tj EMC ET BT 0.361 0.365 0.349 rg /T1_0 1 Tf 0.0491 Tc 8.3 0 0 8.3 328.7124 282.9683 Tm (de )Tj 0.302 0.306 0.29 rg -0.0151 Tc 1.363 0 Td (16%. )Tj 0.0137 Tc 2.343 0 Td (L'absence )Tj 0.361 0.365 0.349 rg -0.0087 Tc 4.333 0 Td (de )Tj 0.025 Tc 1.157 0 Td (changement )Tj 0.05 Tc 8.7609 0 0 8.3 448.72 282.97 Tm (du )Tj 0.302 0.306 0.29 rg 8.343 0 0 8.3 459.29 282.97 Tm (TL', )Tj 0.361 0.365 0.349 rg 0 Tc 8.3 0 0 8.3 476.56 282.97 Tm (a )Tj ET BT /Suspect <>BDC 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0122 Tc 8.3 0 0 8.3 480.9673 282.97 Tm (pres )Tj EMC ET BT /T1_0 1 Tf 0.0149 Tc 8.3 0 0 8.3 497.2851 282.97 Tm (bronchodi\255)Tj 0.361 0.365 0.349 rg 0.0206 Tc -22.969 -1.1 Td (latation )Tj 0.0048 Tc 3.641 0 Td (est )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0123 Tc 8.3 0 0 8.3 350.3253 273.84 Tm (lice )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.3101 0 0 8.3 365.68 273.84 Tm (au )Tj 0.302 0.306 0.29 rg -0.0064 Tc 8.3 0 0 8.3 378.63 273.84 Tm (fait )Tj 0.361 0.365 0.349 rg 0.0065 Tc 1.852 0 Td (que )Tj 0.302 0.306 0.29 rg -0.035 Tc 7.8328 0 0 8.3 410.62 273.84 Tm (!a )Tj 0.361 0.365 0.349 rg 0.0211 Tc 8.3 0 0 8.3 420.36 273.84 Tm (surestimation )Tj 0.302 0.306 0.29 rg 0.05 Tc 6.077 0 Td (du )Tj -0.0031 Tc 1.626 0 Td (temps )Tj 0 Tc 2.827 0 Td (d)Tj 0.451 0.455 0.439 rg 0.577 0 Td (')Tj 0.302 0.306 0.29 rg 0.0277 Tc 0.233 0 Td (apnce )Tj 0.361 0.365 0.349 rg -0.0148 Tc -25.1 -1.04 Td (effective )Tj 0.302 0.306 0.29 rg 0.0048 Tc 3.99 0 Td (est )Tj 0.0169 Tc 1.678 0 Td (contrebalancee )Tj 0.361 0.365 0.349 rg 0.0316 Tc 6.835 0 Td (par )Tj 0.302 0.306 0.29 rg 0.0017 Tc 1.965 0 Td (une )Tj 0.361 0.365 0.349 rg 0.022 Tc 2.072 0 Td (augmentation )Tj 0.05 Tc 6.246 0 Td (du )Tj 0.302 0.306 0.29 rg 0.0031 Tc 1.742 0 Td (volume )Tj 0.361 0.365 0.349 rg 0.0008 Tc -24.47 -1.099 Td (alveolaire )Tj 0.302 0.306 0.29 rg 0.0022 Tc 4.229 0 Td (mesure )Tj 0.05 Tc 8.3101 0 0 8.3 367.12 256.09 Tm (au )Tj 0.0132 Tc 8.3 0 0 8.3 377.68 256.09 Tm (cours )Tj 0.0491 Tc 2.429 0 Td (de )Tj 0.361 0.365 0.349 rg 0.0146 Tc 1.216 0 Td (l'apnee. )Tj 0.0481 Tc 3.367 0 Td (Nous )Tj 0.302 0.306 0.29 rg 0.0165 Tc 2.472 0 Td (concluons )Tj 0.0354 Tc 4.337 0 Td (que )Tj 0.361 0.365 0.349 rg -0.0054 Tc 1.735 0 Td (chez )Tj 0.0036 Tc 1.966 0 Td (des )Tj 0.302 0.306 0.29 rg 0.0048 Tc -26.075 -1.099 Td (malades )Tj 0.0317 Tc 3.52 0 Td (qui )Tj ET BT /Suspect <>BDC 0.361 0.365 0.349 rg /T1_0 1 Tf -0.0018 Tc 8.3 0 0 8.3 349.4185 246.9683 Tm (recoivent )Tj EMC ET BT 0.302 0.306 0.29 rg /T1_0 1 Tf -0.0163 Tc 8.3 0 0 8.3 382.5521 246.9683 Tm (un )Tj 0.0132 Tc 1.328 0 Td (traitement )Tj 0.0155 Tc 4.514 0 Td (bronchodillatateu)Tj 0.204 0.208 0.196 rg 0 Tc 7.284 0 Td (r)Tj 0.361 0.365 0.349 rg 0.39 0 Td (, )Tj 0.302 0.306 0.29 rg 0.05 Tc 8.8071 0 0 8.3 498.17 246.97 Tm (TL )Tj -0.005 Tc 8.3 0 0 8.3 511.12 246.97 Tm (calcule )Tj 0.361 0.365 0.349 rg -0.0005 Tc -24.641 -1.041 Td (selon )Tj 0.0251 Tc 2.322 0 Td (Jones )Tj 0.05 Tc 8.3173 0 0 8.3 346.95 238.33 Tm (et )Tj 0.302 0.306 0.29 rg 0.0171 Tc 8.3 0 0 8.3 356.12 238.33 Tm (Meade )Tj 0.0048 Tc 3.001 0 Td (est)Tj 0.204 0.208 0.196 rg 0 Tc 1.448 0 Td (l)Tj 0.302 0.306 0.29 rg 0.23 0 Td (a )Tj -0.0027 Tc 0.759 0 Td (meileure )Tj 0.361 0.365 0.349 rg 0.025 Tc 3.701 0 Td (methode )Tj 0.302 0.306 0.29 rg -0.0087 Tc 3.867 0 Td (de )Tj -0.0013 Tc 1.222 0 Td (mesure. )Tj 0.204 0.208 0.196 rg 0 Tc 3.406 0 Td (T)Tj 0.302 0.306 0.29 rg 0.0066 Tc 0.698 0 Td (L', )Tj 0.0133 Tc 1.32 0 Td (sous )Tj 0.0032 Tc -25.673 -1.099 Td (estime )Tj 0.0491 Tc 3.066 0 Td (de )Tj 0.0045 Tc 1.511 0 Td (manicre )Tj 0.361 0.365 0.349 rg 0.0119 Tc 3.689 0 Td (systematique )Tj 0.302 0.306 0.29 rg -0.0108 Tc 5.789 0 Td (le )Tj 0.0167 Tc 1.212 0 Td (facteur )Tj 0.0491 Tc 3.298 0 Td (de )Tj 0.0038 Tc 1.511 0 Td (transfer! )Tj -0.0054 Tc 3.925 0 Td (chez )Tj -0.0202 Tc 2.255 0 Td (ces )Tj 0.0015 Tc -26.19 -1.099 Td (malades. )Tj ET endstream endobj 58 0 obj <>/Filter/JBIG2Decode/Height 1752/ImageMask true/Length 31119/Name/X/Subtype/Image/Type/XObject/Width 1240>>stream C;;ku+ e|ϯ 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