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0 g
/GS2 gs
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391.011 647.603 0.51 -189.298 re
f
BT
/F1 1 Tf
14.944 0 0 14.944 157.776 712.403 Tm
0.0208 Tc
[(Airway)-333.9(neutrophils)-333.9(and)-332.6(i)2.1(nterleukin-17)]TJ
/F2 1 Tf
10.959 0 0 10.959 220.082 675.042 Tm
0 Tc
[(A.)-330.8(Linde)]TJ
3.2591 0 TD
[(\302)-111.9(n)0(,)-331(H)0(.)-335.7(Hoshino,)-327.4(M.)-334.5(Laan)]TJ
/F3 1 Tf
8.966 0 0 8.966 58.28 638.135 Tm
[(Airway)-299.3(neutr)30.8(ophils)-300.1(and)-295.7(interleukin-17.)-303.9(A.)-296.7(Linde)]TJ
18.9371 0.0126 TD
0 Tw
(\302)Tj
0.3731 -0.0126 TD
[(n,)-299.6(H.)-296.6(Hoshino,)-297.1(M.)-300(Laan.)]TJ
/F4 1 Tf
10.2052 0 TD
(#)Tj
/F3 1 Tf
0.999 0 TD
[(ERS)-302.6(Journals)]TJ
-30.5144 -1.0559 TD
[(Ltd)-334.6(2000.)]TJ
/F5 1 Tf
T*
[(ABSTRACT)66.7(:)-278.7(I)0(t)-285.7(i)0(s)-287.1(well)-284(known)-281(that)-283(exacerbations)-291.3(of)-278.2(obstructive)-287.2(airways)-287.6(disease)-283.9(such)]TJ
T*
[(as)-208.8(asthma)-213.1(and)-210.6(chron)12.2(ic)-209.8(obstructive)-217.7(pulmonary)-208.7(disease)-214.3(ar)13.9(e)-214.3(associated)-213.7(with)-211.9(an)-206.2(increased)]TJ
0 -1.0496 TD
[(number)-403.7(of)-417.3(neutr)11.2(ophils)-417.4(in)-417.3(the)-415.1(airways.)-417(However)81.3(,)-413.9(the)-415.1(mechanisms)-414.6(behind)-417.1(this)-418.4(phe-)]TJ
0 -1.0559 TD
[(nomenon)-333.8(are)-320.5(poorly)-339.1(understood.)]TJ
0.999 -1.0559 TD
[(There)-354.2(is)]TJ
/F6 1 Tf
3.9012 0 TD
[(in)-360.4(vivo)]TJ
/F5 1 Tf
3.1931 0 TD
[(experimental)-363(evidence)-367.6(that)-358.9(the)-364.5(number)-353.1(of)-360.4(airway)-362.8(neutrophilis)-357.5(is)]TJ
-8.0933 -1.0559 TD
[(controlled)-319.6(by)-320(certain)-326.5(T)84.3(-lymphocytes,)-328.2(but)-325.4(the)-326.6(mediators)-327.3(r)13.4(esponsible)-326.1(for)-328(this)-323.6(lympho-)]TJ
T*
[(cyte-relate)7.8(d)-333.2(neutrophilia)-331(have)-331.4(not)-333.1(yet)-334.3(been)-336.1(identified.)]TJ
0.999 -1.0559 TD
-0.0001 Tc
[(In)-371.9(this)-374.2(review)61.2(,)-376.1(novel)-371.3(evidence)-374(that)-377.9(the)-371(T)84.2(-lymphocyte-related)-377.6(cytokine)-369.1(interleukin)]TJ
-0.999 -1.0559 TD
0 Tc
[(\(IL\)-17)-517.4(can)-509(link)-512.1(the)-516.3(activation)-512.1(of)-512.1(certain)-516.2(T)84.3(-lymphocytes)-515(to)-518.4(the)-510(recru)11.2(itment)-518.5(and)]TJ
T*
[(activation)-328.7(of)-328.7(airway)-324.9(neutrophils)-317.6(is)-331.4(described.)-325.5(The)-330.3(IL-17-induced)-326.2(neutr)11.2(ophil)-328.2(recruit-)]TJ
T*
[(ment)-554.2(is)-552.7(mediated)]TJ
/F6 1 Tf
8.3399 0 TD
(via)Tj
/F5 1 Tf
1.7578 0 TD
[(induced)-549.1(CXC)-552.1(chemokine)-556(r)13.4(elease)-556.3(throug)11.5(h)-548.2(steroid-sensitive)]TJ
-10.0977 -1.0559 TD
[(mechanisms)-294.5(and)-292.8(is)-293.4(modulated)-298.2(by)-288.4(release)-283.6(of)-297.1(endogenous)-293.5(tachykinins.)-289.2(These)-298.7(effects)-297(of)]TJ
T*
[(IL-17)-516.5(ar)13.9(e)-511.4(potentiated)-519.8(by)-509.7(other)-515(pro-inflamm)7.4(atory)-510.4(cytokines)-515.1(such)-514.6(as)-512.3(\(IL-1)]TJ
/F7 1 Tf
33.0119 0 TD
(b)Tj
/F5 1 Tf
0.5501 0 TD
[(\))-512.6(and)]TJ
-33.562 -1.0559 TD
[(tumour)-336.7(necrosis)-321.1(factor)26.9(-)]TJ
/F7 1 Tf
10.0598 0 TD
(a)Tj
/F5 1 Tf
0.6386 0 TD
(.)Tj
-9.6993 -1.0559 TD
[(Clinical)-298(studies)-296.3(are)-282.6(needed)-295.5(to)-290.8(evaluate)-294.6(whether)-288(or)-295.9(not)-288.9(targeting)-301.4(these)-294.9(mechanisms)]TJ
-0.999 -1.0559 TD
[(can)-281.4(provide)-267.4(a)-277.7(useful)-282.9(pharmacotherapeutical)-285.1(approach)-269.4(against)-284.1(exaggerated)-277.6(mobiliza-)]TJ
T*
[(tion)-335(of)-335.1(neutr)11.2(ophils)-335.2(in)-335.1(obstructive)-337.8(airways)-331.9(disease.)]TJ
/F3 1 Tf
T*
[(Eur)-331.9(Respir)-333.8(J)-334.4(2000;)-333.5(15:)-334.6(973\261977.)]TJ
/F8 1 Tf
7.97 0 0 7.97 401.499 639.156 Tm
[(Dept)-521.8(of)-529.5(Respiratory)-519.4(Medicine)-524.6(&)-524.6(Aller)11.2(-)]TJ
0 -1.0599 TD
[(gology)67.1(,)-326.2(Gothenbur)14.9(g,)-331.2(Sweden.)]TJ
0 -2.1268 TD
[(Corresponde)11.8(nce:)-468.5(A.)-461.7(Linde)]TJ
10.5346 0.0427 TD
(\302)Tj
0.377 -0.0427 TD
[(n,)-466.3(Lung)-463.8(Phar)18.6(-)]TJ
-10.9115 -1.067 TD
[(macology)-688(Group,)-688.2(Dept)-685.4(of)-693.1(Respiratory)]TJ
0 -1.0599 TD
[(Medicine)-467.7(&)-467.7(Aller)11.2(gology)67.1(,)-468.4(Guldhedsgata)12.7(n)]TJ
T*
[(10A,)-621.1(SE-413)-628.2(46)-621.8(Gothenbur)14.9(g,)-622.8(Sweden.)]TJ
0 -1.067 TD
[(Fax:)-325.1(46)-330.1(31413290)]TJ
0 -2.1197 TD
[(Keywords)11.5(:)-320.4(Airway)70.1(,)-319(cytokine,)-312.1(elastase,)-312.4(in-)]TJ
0 -1.067 TD
[(terleukin-8)10.5(,)-333.3(myeloperoxida)10.9(se,)-329.2(neutrophil)]TJ
0 -2.1268 TD
[(Received:)-327.9(June)-326.1(25)-330.1(1999)]TJ
0 -1.0599 TD
[(Accepted)-204.5(after)-217.8(revision)-208.8(December)-209.7(30)-209.2(1999)]TJ
0 -2.1268 TD
[(This)-318(work)-321.5(was)-316.5(funded)-320.9(by)-315.9(Hermann)-320.5(Kref-)]TJ
0 -1.0599 TD
(ting)Tj
/F9 1 Tf
1.5364 0 TD
(')Tj
/F8 1 Tf
0.2205 0 TD
[(s)-525.5(Foundation)12.4(,)-532.4(the)-521.5(Swedish)-521.6(Medical)]TJ
-1.7569 -1.0599 TD
[(Research)-113.2(Council)-121.8(\(K97-04)11.9(X-09-04-8-08A,)]TJ
0 -1.067 TD
[(U1268\),)-508.3(the)-521.5(V)106.3(a)3.1(rdal)-519.5(Foundation)-506.9(and)-511.9(the)]TJ
0 -1.0599 TD
[(Swedish)-294(Heart)-291.3(Lung)-293(Foundation)12.4(.)-297.7(N)0(o)-297.1(sup-)]TJ
0 -1.067 TD
[(port,)-299(direct)-296.2(or)-301.8(indirect,)-300.4(was)-295.1(obtained)-298.9(from)]TJ
0 -1.0599 TD
[(the)-329.4(tobacco)-326.1(industry)67.6(.)]TJ
9.963 0 0 9.963 68.258 432.113 Tm
[(Ex)17.1(ac)14.7(er)19.2(ba)20.8(ti)16.5(on)15.5(s)-394.6(o)0(f)-390.1(o)0(b)15.5(s)0(t)17.7(r)0(u)19.6(c)0(t)18.5(i)0(v)13.2(e)-393.8(ai)18.4(rw)15.7(ay)15.1(s)-394.6(d)0(i)13.2(s)0(e)19.6(a)0(s)19.6(e)0(s)-390.1(s)0(u)14.4(c)0(h)-388.9(a)0(s)]TJ
-1.0015 -1.0698 TD
[(as)19.6(th)13.2(ma)-175.8(an)15.1(d)-188.6(c)0(h)20.8(r)0(o)19.6(n)0(i)13.2(c)-183.3(ob)15.5(st)17.7(ru)19.6(ct)12.8(iv)18.9(e)-189(p)0(u)21.2(l)0(m)15.7(o)0(n)15.5(a)0(r)19.2(y)-188.6(di)18.9(se)19.6(as)13.9(e)-183.3(\()0(C)14.9(O)0(P)18.1(D)0(\))]TJ
T*
[(ma)17.7(y)-410.5(b)0(e)-406(a)0(s)19.6(s)0(o)20(c)0(i)12.8(a)0(t)18.4(e)0(d)-400.3(w)0(i)14.9(t)0(h)-402.2(a)0(n)-400.3(i)0(n)18.9(c)0(r)13.5(e)0(a)20.4(s)0(e)13.9(d)-410.5(nu)21.2(mb)18.1(er)-407.6(of)-401.5(ne)20.8(ut)18.9(ro)13.9(-)]TJ
T*
[(ph)15.5(il)22.2(ic)-243.3(gr)19.6(an)15.1(ul)18.9(oc)15.1(yt)18.9(es)-236.4(in)-242.9(th)18.9(e)-251.6(a)0(i)18.4(r)0(w)15.7(a)0(y)20.8(s)0(.)-241.3(T)0(h)17.1(i)0(s)-238.4(h)0(a)15.1(s)-246.7(be)15.1(en)-235.2(in)13.2(di)18.9(ca)20.4(te)12.8(d)]TJ
T*
[(by)-343(st)17.7(ud)21.2(ie)12.8(s)-349.1(i)0(n)18.9(v)0(o)15.5(l)13.9(vi)13.2(ng)-337.3(br)13.9(on)21.2(ch)15.1(oa)20.8(lv)13.2(eo)20.8(la)18.4(r)-355.2(l)0(a)18.4(v)0(a)20.8(g)0(e)-343.4(\()0(B)14.9(A)0(L)18.9(\))-349.5(fl)17.3(ui)13.2(d)]TJ
T*
[(an)15.1(d)-336.5(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(i)0(a)18.4(l)-338.9(bi)18.9(op)15.5(sy)-327.1(sa)13.9(mp)18.1(le)18.4(s)-337.7(a)0(s)-327.5(w)0(e)11.2(l)13.9(l)-338.9(a)0(s)-333.2(i)13.9(nd)15.5(uc)15.1(ed)-326.3(sp)20(ut)13.2(um)]TJ
T*
[(fr)18(om)-499.8(pa)15.1(ti)16.5(en)20.8(ts)-500.2([1)13.9(\2616].)-522.1(Recent)-525(data)-524.1(sugges)-7.4(t)-515.3(that)-526.1(this)-521.2(in-)]TJ
T*
[(creased)-413.8(number)-408.1(of)-401.5(airwa)-12.5(y)-399.1(neutr)-8.2(ophils)-408.9(is)-403.4(not)-403(associ)-10.1(ated)]TJ
T*
[(with)-336.1(d)-6.5(etectable)-340.4(airway)-343.3(infec)-8.6(tion)-337.9([6].)]TJ
1.0015 -1.0528 TD
[(Ne)16.9(ut)18.9(ro)13.9(ph)21.2(il)16.5(s)-428.7(a)0(r)19.2(e)-428(ca)20.4(pa)15.1(bl)18.9(e)-422.3(o)0(f)-418.5(r)0(e)13.5(l)13.9(ea)14.7(si)17.7(ng)-416.9(me)17.7(di)18.9(at)12.8(or)19.6(s)-423.1(w)0(h)17.3(i)0(c)12.8(h)]TJ
-1.0015 -1.0698 TD
[(ca)14.7(us)20(e)-450.7(e)0(f)30.6(f)0(e)13.5(c)0(t)18.5(s)-451.5(t)13.9(h)0(a)15.1(t)-447(re)13.5(se)19.6(mb)18.1(le)-442.5(ex)15.1(ac)20.4(er)13.5(ba)20.8(ti)16.5(on)15.5(s)-445.8(o)0(f)-441.3(o)0(b)15.5(s)0(t)17.7(r)0(u)19.6(c)0(t)18.4(i)0(v)13.2(e)]TJ
T*
[(ai)18.4(rw)15.7(ay)15.1(s)-314.9(d)0(i)18.9(s)0(e)19.6(a)0(s)13.9(e)0(.)-303.1(F)0(o)16.3(r)-315.3(ex)15.1(am)17.7(pl)18.9(e,)-308.8(ne)20.8(ut)18.9(ro)13.9(ph)21.2(il)16.5(s)-314.9(c)0(a)14.7(n)-313.7(re)19.2(le)12.8(as)19.6(e)-314.1(e)0(n)15.1(-)]TJ
T*
[(zy)15.1(me)17.7(s)-269.4(s)0(u)14.4(c)0(h)-263.7(a)0(s)-259.2(n)0(e)15.1(u)0(t)18.9(r)0(o)19.6(p)0(h)15.5(i)0(l)-262.4(e)0(l)18.4(a)0(s)13.9(t)0(a)18.4(s)0(e)-264.9([)0(7)19.6(,)-284.9(8],)-282.3(a)-280(seri)-8.6(ne)-280.8(prote)-8.2(ase)]TJ
T*
[(that)-480.5(degrade)-8.1(s)-474.3(elastin)-481.1(and)-475(exert)-8.6(s)-474.3(a)-473.5(potent)-482.1(secretago)-13.7(gue)]TJ
T*
[(effect)-324.3(on)-331.6(airway)-332(g)-6.5(land)-330.2(cells)-334.9([8,)-327.9(9],)-327.9(an)-7.6(d)-325.1(may)-330.2(thus)-336.7(contri-)]TJ
T*
[(bute)-250.5(to)-254.3(lung)-250.1(tissue)-256.8(damage)-253.6(and)-253.1(to)-248.6(airway)-258(gland)-251.3(hypers)-7.8(ec-)]TJ
T*
[(retion)-324.3(respective)-11.1(ly)-316.9([8,)-316.5(10].)-317.2(Neutroph)-8.7(ils)-321.2(can)-316.1(also)-320(produce)]TJ
T*
[(oxygen)-278.1(free)-280.2(radic)-8.6(als,)-279.8(which)-278(cause)-279.4(incre)-8.6(ased)-278.2(trans)-9.4(cription)]TJ
T*
[(of)-264.9(the)-266.8(mess)-9(enger)-268(ribonuclei)-11.5(c)-262.9(acid)-268(\(mRN)-10.7(A\))-263.1(for)-267.2(the)-266.8(potent)]TJ
T*
[(neutr)-8.2(ophil)-241.9(chemo)-7.8(attractan)-11.5(t)-242.2(interleuk)-10.7(in)-242.9(\(IL\)-8)-242.7(in)-242.9(bronchi)-9.7(al)]TJ
T*
[(epithe)-10.1(lial)-261(cells)-266.7([1)31(1\26113].)-267.6(Furthermor)-11.9(e,)-257.6(neutr)-8.2(ophils)-266.6(can)-259.2(rel-)]TJ
T*
[(ease)-364(IL-8)-363.2(in)-362.4(respon)-7.8(se)-355.9(to)-362.4(eosin)-7.8(ophil)-361.4(granul)-9(e)-359.7(major)-364.1(basic)]TJ
T*
[(prote)-8.2(in)-339.7([14],)-348.1(which)-346.3(is)-340.8(of)-344.6(inte)-8.2(rest)-344.4(because)-349.6(the)-340.8(numbe)-7.4(r)-343.8(o)0(f)]TJ
T*
[(eosin)-7.8(ophils,)-386.5(just)-384.6(as)-384.4(the)-386.3(IL-8)-385.9(level,)-385.3(is)-386.4(often)-383.8(incre)-8.6(ased)-386.3(in)]TJ
T*
[(asthmati)-12.7(c)-285.7(airways)-294.1([5,)-288(15].)-288.8(In)-287.7(addit)-9(ion)-283.5(to)-288.4(this)-9(,)-284.9(neutrophil)-11.1(s)]TJ
T*
[(can)-276.2(release)-279.6(the)-272.5(pro-i)-9.4(nflamma)-10.7(tory)-274.5(cytokine)-279.1(tumour)-279.2(necro-)]TJ
T*
[(sis)-291.6(factor-)]TJ
/F7 1 Tf
3.9379 0 TD
(a)Tj
/F8 1 Tf
0.9219 0 TD
(\(TNF-)Tj
/F7 1 Tf
2.5266 0 TD
(a)Tj
/F8 1 Tf
0.6373 0 TD
[(\))-286.9([16],)-291.2(which)-289.4(is)-289.6(increased)-292.5(in)-288.4(obstr)-9(uc-)]TJ
-8.0237 -1.0698 TD
[(tive)-457.8(airways)-459.1(disea)-8.2(se)-452.7([15],)-456.2(and)-452.3(this)-458.6(cytokine)-455.5(can)-458.3(cause)]TJ
T*
[(bronchi)-9.7(al)-294.5(smoo)-7.4(th)-299.8(muscle)-302.3(hyperr)-8.2(espons)-7.4(iveness)-301.1([17],)-302.5(pos-)]TJ
T*
[(sibly)-459.3(through)-458.9(the)-454.6(relea)-9(se)-452.7(of)-452.7(the)-460.3(CXC)-453.8(ch)-7.6(emokine)-461.2(IL-8)]TJ
T*
[(from)-367.9(bronchial)-366.8(epit)-8.2(helial)-365.3(cells)-363.4([17\26119])-8.5(.)-358.9(The)-365.3(recruitm)-12.3(ent)]TJ
25.1977 32.0776 TD
[(and)-389.7(a)-6.9(ctivation)-392.8(of)-390.1(neutr)-8.2(ophils)-391.8(in)-390.9(the)-392(airways)-396.5(may)-392.8(there-)]TJ
0 -1.0755 TD
[(fore)-376.5(co)-7.6(ntribute)-379.4(to)-373.8(excacerb)-9.7(ations)-380.8(of)-373(obstructi)-11.5(ve)-371.8(airways)]TJ
T*
[(disea)-8.2(se.)-322.2(This)-318(also)-320(means)-327.6(that)-321.2(factors)-325.9(controlling)-327.2(the)-318.1(me-)]TJ
T*
[(diat)-8.2(ors)-505.8(affecting)-505.4(neutr)-8.2(ophil)-509.3(recruitm)-12.3(ent,)-506.2(such)-505.4(as)-509.6(CXC)]TJ
0 -1.0698 TD
[(che)-8.8(mokines)-319.7(or)-321.8(tachyk)-7.8(inins)-322.8([12,)-317.2(13,)-320.6(20],)-317.2(may)-324.5(play)-318.8(a)-314.2(role)]TJ
0 -1.0755 TD
[(in)-487.6(triggeri)-11.1(ng)-479.5(exacerba)-9.7(tion)-7.8(s)-480(o)0(f)-486.8(obstructive)-491.4(airways)-493.2(dis-)]TJ
T*
(ease.)Tj
/F5 1 Tf
5.7418 -4.8028 TD
[(The)-336.7(role)-330.6(of)-333.2(T)79.9(-lymph)-9.3(ocytes)]TJ
/F8 1 Tf
-4.7402 -2.4469 TD
[(It)-210.4(i)13.9(s)-218.2(l)13.9(i)0(k)13.2(e)0(l)18.4(y)-211.3(th)18.8(at)-209.2(T)91.9(-)0(l)17.3(y)0(m)18.1(p)0(h)21.2(o)0(c)15.1(y)0(t)18.9(e)0(s)-202.3(o)0(f)-208(t)0(h)18.8(e)-211.7(CD)12.6(4+)-201.3(su)14.4(bs)20(et)-203.5(pl)18.9(ay)-206.8(a)]TJ
-1.0015 -1.0755 TD
[(ce)14.7(nt)18.9(ra)13.5(l)-469.8(r)0(o)13.9(l)0(e)-465.2(i)0(n)-464.8(t)0(h)18.9(e)-479.2(re)19.2(cr)19.2(ui)13.2(t)13.9(m)0(e)12(n)0(t)-464.8(o)0(f)-464.1(g)0(r)13.9(a)0(n)20.8(u)0(l)18.9(o)0(c)15.1(y)0(t)18.9(e)0(s)-464.1(i)0(n)13.2(t)0(o)-464.8(t)0(h)18.9(e)]TJ
T*
[(ai)12.8(rw)15.7(ay)-383.2(lu)18.9(me)17.7(n)-399.1(i)13.9(n)-399.1(o)0(b)21.2(s)0(t)17.7(r)0(u)13.9(c)0(t)18.4(i)0(v)18.9(e)-393.8(ai)18.5(rw)15.7(ay)15.1(s)-394.6(d)0(i)18.9(s)0(e)19.6(a)0(s)13.9(e)-393.8([2)19.6(,)-398.7(2)0(1)21.2(\261)0(2)15.5(3)0(])19.6(.)]TJ
T*
[(Fo)16.3(r)-548.7(a)0(s)13.9(t)0(h)18.8(m)0(a)17.7(,)-546.7(th)13.2(is)-540(is)-540(su)20(pp)15.5(or)19.6(te)18.4(d)-552.7(b)0(y)-536.4(t)0(h)18.8(e)-553.2(ob)21.2(se)14(rv)19.6(at)18.4(io)13.2(n)-547.1(t)0(h)18.9(a)0(t)]TJ
T*
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T*
[([36].)-296.8(In)-293.3(addit)-9(ion)-294.9(to)-294.1(this,)-293.9(it)-296.5(has)-294.1(now)-296.4(also)-297.2(been)-294.1(show)-8.2(n)-291(that)]TJ
T*
[(selec)-8.6(tive)-258.6(neutrophil)-261.5(recrui)-11(tment)-256.8(can)-259.2(be)-252.3(achiev)-8.2(ed)-258(by)-251.9(indu-)]TJ
0 -1.0641 TD
[(cing)-142.4(overexp)-7.7(ression)-148.7(of)-139.7(the)-141.7(IL-17)-142(gene)-140.4(in)-140.5(mic)-8.2(e)-137.7(airways)-146.1([37].)]TJ
0 -1.0698 TD
[(Pretr)-9(eatment)-333.1(with)-330.4(dexam)-7.8(ethason)-9.7(e)-325.5(attenuates)-336.2(the)-329.4(hIL-17-)]TJ
T*
[(induce)-7.8(d)-194.2(incre)-8.6(ase)-197.8(in)-197.4(BAL)-197.2(neu)-8.4(trophils,)-204.2(thereby)-203.6(pointing)-201(out)]TJ
0 -1.0641 TD
[(a)-262.9(steroid-s)-11.9(ensitive)-271.3(mechanism)-268.3(of)-264.9(acti)-8.6(on)]TJ
/F3 1 Tf
15.9847 0 TD
[(in)-265.7(vivo)]TJ
/F8 1 Tf
2.942 0 TD
[(as)-264.9(well)-268.2(as)]TJ
/F3 1 Tf
-18.9268 -1.0698 TD
[(in)-407.9(vitr)24.7(o)]TJ
/F8 1 Tf
3.42 0 TD
[([35].)-416.3(This)-409.1(provi)-7.8(des)-407.9(additional)-416.3(eviden)-7.8(ce)-412.1(for)-409.5(the)]TJ
-3.42 -1.0698 TD
[(univer)-9(sal)-279.4(anti-inflam)-13.7(matory)-279.6(effect)-273.1(of)-282(glucocorti)-11.5(coids)-280.9(and)]TJ
T*
[(suppor)-7.4(ts)-477.4(the)-477.4(idea)-484.3(that)-480.5(glucoc)-7.8(orticoids)-483.8(act,)-478.2(in)-481.9(part,)]TJ
/F3 1 Tf
21.5899 0 TD
(via)Tj
/F8 1 Tf
-21.5899 -1.0641 TD
[(inhibit)-9.2(ion)-334.7(of)-338.9(cytokine)-341.7(production)-344.4([38].)]TJ
1.0015 -1.0527 TD
[(Th)17.1(e)-200.3(i)0(n)18.8(v)0(o)15.5(l)0(v)18.9(e)0(m)17.7(e)0(n)15.1(t)-202.3(of)-190.9(ma)17.7(cr)13.5(op)21.2(ha)15.1(ge)-189.7(in)18.9(fl)17.3(am)12(ma)17.7(to)18.9(ry)-190.9(pr)13.9(ot)18.9(ei)18.4(n-)13.9(2)]TJ
-1.0015 -1.0641 TD
[(\(M)17.7(IP)14.7(-2)19.6(\),)-287.3(th)18.9(e)-297.1(r)0(a)19.2(t)-299.1(co)20.8(rr)12.4(el)18.4(at)18.5(e)-297.1(t)0(o)-282.7(I)0(L)15.5(-)0(8)13.9(,)-290.6(ha)15.1(s)-292.2(a)0(l)12.8(s)0(o)-287.3(b)0(e)20.8(e)0(n)-286.5(e)0(v)15.1(a)0(l)18.4(u)0(a)20.8(t)0(e)12.8(d)]TJ
0 -1.0698 TD
[(in)-294.1(ra)13.5(t)-299.1(a)0(i)12.8(r)0(w)15.7(a)0(y)20.8(s)]TJ
/F3 1 Tf
5.7019 0 TD
[(in)-294.1(vi)18.4(vo)]TJ
/F8 1 Tf
2.6746 0 TD
[(,)-302(a)0(n)15.1(d)-302.4(th)18.9(e)-302.8(r)0(e)13.5(s)0(u)20(l)0(t)16.5(s)-303.6(co)15.1(nf)19.6(ir)17.3(m)-305.5(t)0(h)18.9(a)0(t)-294.5(h)0(I)13.9(L)12.2(-1)13.9(7)]TJ
-8.3765 -1.0698 TD
[(in)18.9(st)17.7(il)16.5(le)18.4(d)-473.1(i)0(n)18.9(t)0(r)17.3(a)0(t)18.5(r)0(a)19.2(c)0(h)15.1(e)0(a)20.4(l)0(l)16.5(y)-473.1(in)18.9(cr)19.2(ea)14.7(se)19.6(s)-468.6(t)0(h)18.9(e)-473.5(le)18.4(ve)20.8(l)-469.8(o)0(f)-464.1(t)0(h)18.9(i)0(s)-460.3(C)11.6(XC)]TJ
T*
[(ch)15.1(em)17.7(ok)21.2(in)13.2(e)-354(i)13.9(n)-353.6(B)0(A)12.6(L)-352(fl)17.3(ui)18.9(d)-353.6([)0(3)13.9(5].)-350.6(The)-365.3(findi)-10.2(ng)-360(that)-372.4(pretreat-)]TJ
25.1977 44.5741 TD
[(ment)-230.9(with)-228(a)-223.1(neutraliz)-11.1(ing)-220.9(anti)-8.2(body)-225(direc)-8.6(ted)-221.3(agains)-9(t)-225.1(mMIP-)]TJ
0 -1.0471 TD
[(2)-438.9(significan)-12.7(tly)-433.8(reduces)-441.8(the)-437.6(incre)-8.6(ase)-436.8(in)-430.7(BAL)-441.8(neutr)-8.2(ophil)]TJ
0 -1.0528 TD
[(numbe)-7.4(r)-400.7(caused)-405.3(by)-399.9(hIL-17)-404.5(provi)-7.8(des)-396.5(addit)-9(ional)-401.6(eviden)-7.8(ce)]TJ
0 -1.0471 TD
[(for)-341.2(the)-335.1(involvem)-8.7(ent)-335.1(of)-338.9(MIP-2)-338.2([35].)]TJ
/F5 1 Tf
2.0258 -2.134 TD
[(Interl)-9.8(eukin-17)-343.9(acts,)-336.7(in)-333.2(pa)-6.4(rt,)]TJ
/F6 1 Tf
12.229 0 TD
(via)Tj
/F5 1 Tf
1.5421 0 TD
[(en)-6.8(dogenous)]TJ
-6.8457 -1.0471 TD
[(tachyki)-8.1(nins)]TJ
/F8 1 Tf
-7.9497 -1.5535 TD
[(Th)17.1(e)-405.2(r)0(o)13.9(l)0(e)-397(o)0(f)-395.8(e)0(n)20.8(d)0(o)15.5(g)0(e)20.8(n)0(o)15.5(u)0(s)-395.4(t)0(a)18.5(c)0(h)15.1(y)0(k)21.2(i)0(n)18.8(i)0(n)13.2(s)-400.3(in)-396.6(IL)15.5(-1)19.6(7-)14(in)18.9(du)21.2(ce)14.7(d)]TJ
-1.0015 -1.0471 TD
[(ai)12.8(rw)15.7(ay)-303.5(ne)15.1(ut)18.9(ro)19.6(ph)15.5(il)16.5(ia)-305.9(ha)20.8(s)-320.6(a)0(l)18.4(s)0(o)-304.3(b)0(e)15.1(e)0(n)-303.5(e)0(v)15.1(a)0(l)18.5(u)0(a)15.1(t)0(e)18.4(d)-313.7([3)13.9(6].)-316.5(The)-325.5(re-)]TJ
0 -1.0528 TD
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0 -1.0471 TD
[(pho)-8(sphoramid)-9.9(on)-223.5(plus)-228.6(cap)-8.8(topril)-229.6(signifi)-9.6(cantly)-232.1(enhances)-230.8(the)]TJ
0 -1.0527 TD
[(numbe)-7.4(r)-281.2(o)0(f)-282(neutr)-8.2(ophils,)-284.1(but)-283.5(not)-283.5(that)-281.4(of)-282(other)-287(cell)-287.5(types,)-281.3(in)]TJ
0 -1.0471 TD
[(BAL)-248.4(fluid)-249.2(from)-242.7(rats)-247.6(treated)-251.9(intratra)-11.6(cheally)-250.3(with)-245.1(hIL-17)]TJ
/F3 1 Tf
22.0281 0 TD
(in)Tj
-22.0281 -1.0528 TD
(vivo)Tj
/F8 1 Tf
1.9519 0 TD
[([36].)-302.5(The)-302.7(relative)-306.3(magni)-9.7(tude)-301.7(of)-304.7(this)-299.2(effect)-301.6(is)-301(similar)]TJ
-1.9519 -1.0471 TD
[(after)-357.3(corres)-9.8(pondin)-7(g)-347.9(treatmen)-11.1(t)-350.3(with)-353.2(rIL-1)]TJ
/F7 1 Tf
16.4457 0 TD
(b)Tj
/F8 1 Tf
0.8991 0 TD
[([36].)-353.7(In)-350.2(add)-8.4(i-)]TJ
-17.3448 -1.0528 TD
[(tion)-7.8(,)-472.7(pretr)-9.8(eatment)-481.1(wi)-7.8(th)-476.2(phospho)-6.5(ramidon)-485.2(plus)-478.9(captop)-7.8(ril)]TJ
0 -1.0471 TD
[(doe)-8.4(s)-343.4(not)-346.1(signi)-9.8(ficantly)-351.4(incre)-8.6(ase)-351.4(the)-346.5(neutr)-8.2(ophil)-350(numbe)-7.4(r)-343.8(i)0(n)]TJ
0 -1.0527 TD
[(BAL)-396.3(fluid)-397.1(from)-396.3(rats)-389.9(treat)-11(ed)-388.9(with)-398.7(the)-392(vehicle)-398.3(of)-390.1(hIL-17)]TJ
0 -1.0471 TD
[(alone)-257.4([36],)-251.3(there)-8.6(by)-246.2(sugges)-7.4(ting)-252.5(that)-252.9(IL-17)-255.8(acts,)-252.5(in)-248.6(part,)]TJ
/F3 1 Tf
21.5899 0 TD
(via)Tj
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[(relea)-9(se)-447(of)-447(endogeno)-6.9(us)-446.6(tachyk)-7.8(inins.)-448.3(Also,)-449.1(in)-447.8(rats)-446.8(given)]TJ
0 -1.0471 TD
[(hIL)-8(-17)-180.3(intratrac)-12.7(heally)58.1(,)-176.8(pretr)-9.8(eatment)-185.2(with)-182.5(phospho)-6.5(ramidon)]TJ
0 -1.0528 TD
[(enh)-8.4(ances)-387.5(the)-392(neutrophil)-398(number)-391(in)-390.9(BAL)-390.6(fluid,)-391.8(whereas)]TJ
0 -1.0471 TD
[(cap)-8.8(topril)-394.6(does)-391.6(not)-391.6([36].)-393.6(Fu)-6.4(rthermor)-11.1(e,)-388.5(pretr)-9.8(eatment)-395.7(with)]TJ
0 -1.0527 TD
[(the)-403.4(selective)-403.8(neuroki)-9.7(nin)-397.3(\(NK\)-)-10.8(1)-399.1(receptor)-405.5(antago)-7.8(nist)-396(SR)]TJ
0 -1.0471 TD
[(140)-8(333)-451.8(signi)-9.8(ficantly)-459.5(reduces)-464.6(the)-454.6(neutr)-8.2(ophil)-458.1(numbe)-7.4(r)-451.9(i)0(n)]TJ
0 -1.0527 TD
[(BAL)-288.2(fluid)-289(after)-283.3(treat)-11(ment)-282.1(with)-284.9(h)-6.5(IL-17,)-284.7(but)-283.5(this)-282.2(is)-283.9(not)-283.5(the)]TJ
0 -1.0471 TD
[(case)-346.9(after)-351.6(pretreatm)-13.5(ent)-340.8(with)-347.5(the)-346.5(selective)-352.6(NK-2)-342.6(recept)-9.8(or)]TJ
0 -1.0527 TD
[(antago)-7.8(nist)-396(SR)-386.7(48968)-390.8([36].)-393.6(T)63.4(a)-6.9(ken)-389.7(together)20.9(,)-387.3(these)-389.5(obser-)]TJ
0 -1.0471 TD
[(vati)-8.2(ons)-231.1(point)-230.5(out)-232.3(the)-232.7(NK-1)-234.4(recept)-9.8(or)-230.7(as)-230.7(an)-229.6(importan)-10.3(t)-230.8(tar)10.4(get)]TJ
0 -1.0528 TD
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/F5 1 Tf
1.5649 -2.1283 TD
[(Interl)-9.8(euk)-6.8(in-17)-337.1(activa)-9(tes)-335.5(neutrophils)-332.3(ind)-8.8(ir)12.8(ectly)]TJ
/F8 1 Tf
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[(Th)17.1(e)-245.9(c)0(a)14.7(p)0(a)20.8(c)0(i)18.4(t)0(y)-237.2(o)0(f)-236.4(I)0(L)21.2(-)0(1)13.9(7)-239.8(to)-237.2(ac)14.7(t)13.9(i)0(v)13.2(a)0(t)18.4(e)-245.9(ai)18.5(rw)15.7(ay)-235.2(ne)20.8(ut)18.9(ro)13.9(ph)21.2(il)16.5(s)-246.6(h)0(a)20.8(s)]TJ
-1.0015 -1.0471 TD
[(be)15.1(en)-223.9(ev)20.8(al)18.4(ua)15.1(te)18.4(d)-228.4(b)0(y)-223.5(a)0(n)15.1(a)0(l)18.5(y)0(s)20(i)0(n)18.8(g)-234.1(th)18.8(e)-228.8(a)0(c)14.7(t)0(i)16.5(v)0(i)18.9(t)0(y)-220.2(o)0(f)-225.1(t)0(w)20.6(o)-234.1(ne)20.8(ut)18.8(ro)14(ph)21.2(il)16.5(-)]TJ
0 -1.0528 TD
[(re)13.5(la)18.4(te)18.4(d)-336.5(e)0(n)20.8(z)0(y)15.1(m)0(e)17.7(s)-332(in)-328.3(th)18.8(e)-331.2(c)0(e)14.7(l)0(l)16.5(-)0(f)18(r)0(e)19.2(e)-336.9(co)20.8(mp)12.4(on)21.2(en)15.1(t)-333.2(o)0(f)-327.5(B)11.6(AL)-328.2(fl)17.3(ui)18.8(d)]TJ
0 -1.0471 TD
[(su)14.4(pe)20.8(rn)13.9(at)18.5(an)20.8(t)-469.8(f)0(r)18(o)0(m)-459.9(r)0(a)13.5(t)-464.1(ai)18.5(rw)15.7(ay)15.1(s)]TJ
/F3 1 Tf
12.2631 0 TD
[(in)-459.2(vi)18.4(vo)]TJ
/F8 1 Tf
3.3119 0 TD
[([3)13.9(9].)-464.4(A)-482.7(moderate)]TJ
-15.575 -1.0527 TD
[(incre)-8.6(ase)-362.8(in)-362.4(elast)-10.6(ase)-362.8(activity)-369.3(is)-363.6(presen)-8.2(t)-361.6(after)-363(intr)-9.4(atracheal)]TJ
0 -1.0471 TD
[(treat)-11(ment)-270.7(wi)-7.8(th)-271.4(hIL-17)-273.7([36],)-274.1(and,)-276.2(in)-271.4(contra)-9.4(st,)-267.2(intr)-9.4(atracheal)]TJ
0 -1.0528 TD
[(inst)-9(illation)-320(of)-310.4(rIL)-9.6(-1)]TJ
/F7 1 Tf
7.7505 0 TD
(b)Tj
/F8 1 Tf
0.865 0 TD
[(alone)-320(does)-317.6(not)-312(cause)-319.2(a)-308.5(corres)-9.8(pond-)]TJ
-8.6155 -1.0471 TD
[(ing)-522.5(incre)-8.6(ase)-522.1(at)-522.2(an)-519.8(equall)-10.1(y)-518.6(effective)-522.9(dose)-522.5(in)-521.8(terms)-524.7(of)]TJ
0 -1.0528 TD
[(neu)-8.4(trophil)-389.7(recrui)-11(tment.)-393.8(Rats)-387.3(pretr)-9.8(eated)-388.7(wi)-7.8(th)-385.2(a)-388.1(threshold)]TJ
0 -1.0471 TD
[(dose)-351.8(of)-350.2(rIL-1)]TJ
/F7 1 Tf
5.4231 0 TD
(b)Tj
/F8 1 Tf
0.8934 0 TD
[(displ)-9.8(ay)-343.4(a)-348.3(signifi)-9.6(cant)-347.7(enha)-9.6(ncement)-353.5(of)-344.6(the)]TJ
-6.3165 -1.0528 TD
[(elast)-10.6(ase)-453.8(activity)-460.3(induce)-7.8(d)-450.3(b)0(y)-456.8(hIL-17,)-456.1(where)-10.1(as)-452.7(the)-454.6(BAL)]TJ
0 -1.0471 TD
[(neu)-8.4(trophil)-338.4(count)-336.6(rema)-8.6(ins)-335.9(unalt)-9(ered.)]TJ
1.0015 -1.0527 TD
[(Qu)11.6(i)13.9(t)0(e)-414(s)0(i)17.7(m)0(i)15.7(l)0(a)18.4(r)-423.5(t)13.9(o)-421.9(it)16.5(s)-417.4(e)0(f)24.9(f)0(e)19.2(c)0(t)-414(o)0(n)-411.2(e)0(l)18.5(a)0(s)19.6(t)0(a)18.4(s)0(e)-412.8(a)0(c)14.7(t)0(i)16.5(v)0(i)18.9(t)0(y)81.5(,)-421.5(hI)19.6(L-)15.5(17)]TJ
-1.0015 -1.0471 TD
[(in)13.2(cr)19.2(ea)14.7(se)19.6(s)-326.3(m)0(y)12.4(e)0(l)18.4(o)0(p)21.2(e)0(r)13.5(o)0(x)21.2(i)0(d)13.2(a)0(s)19.6(e)-331.2(ac)20.4(ti)16.5(vi)18.9(ty)-322.6(in)-322.6(ce)20.4(ll)16.5(-f)18(re)13.5(e)-325.5(B)0(A)12.6(L)-329.2(fl)17.3(ui)18.8(d)]TJ
0 -1.0528 TD
[(su)14.4(pe)20.8(rn)13.9(at)18.5(an)20.8(t,)-436(wh)11.6(er)19.2(ea)20.4(s)-445.8(I)0(L)15.5(-)0(1)]TJ
/F7 1 Tf
10.5048 0 TD
(b)Tj
/F8 1 Tf
0.9958 0 TD
[(do)21.2(es)-441.3(no)21.2(t)-447([)0(3)19.6(9].)-447.4(Pretr)-9(eatment)]TJ
-11.5006 -1.0471 TD
[(wi)-7.8(th)-225.8(a)-228.8(thres)-9.4(hold)-233.1(dose)-232.3(of)-230.7(rIL-1)]TJ
/F7 1 Tf
11.7681 0 TD
(b)Tj
/F8 1 Tf
0.7796 0 TD
[(signifi)-9.6(cantly)-232.1(enhances)-236.5(the)]TJ
-12.5477 -1.0527 TD
[(myel)-9(operoxi)-9.7(dase)-329.4(acti)-8.6(vity)-332.2(induce)-7.8(d)-325.1(b)0(y)-331.6(hIL-17,)-336.6(in)-328.3(analog)-7.8(y)]TJ
0 -1.0471 TD
[(wi)-7.8(th)-476.2(its)-474.9(potent)-9.7(iating)-478.7(effect)-472.3(on)-479.5(hIL-17-induce)-10.6(d)-478.8(elastase)]TJ
0 -1.0528 TD
[(acti)-8.6(vity)60.5(.)-256.5(Inter)-9.8(estingly)53.4(,)-250.8(i)0(n)-260(hIL-17-t)-11.7(reated)-260.2(airways,)-266(the)-261.2(elas-)]TJ
T*
[(tase)-252.1(activity)-249.7(correl)-11(ates)-246.4(strongly)-252.7(with)-250.7(the)-244.1(myeloperox)-9.9(idase)]TJ
0 -1.0471 TD
[(acti)-8.6(vity)60.5(,)-250.8(maki)-9(ng)-251.9(a)-251.6(mecha)-8.2(nistic)-258(associ)-10.1(ation)-259.4(of)-253.5(elastase)-259.6(and)]TJ
0 -1.0527 TD
[(myel)-9(operoxi)-9.7(dase)-335.1(relea)-9(se)-333.2(feasi)-9.8(ble.)]TJ
1.0015 -1.0471 TD
[(By)-450.1(us)20(in)18.9(g)-456(a)-456.4(sp)20(ec)14.7(if)17.3(ic)-442.5(in)13.2(hi)18.9(bi)18.9(to)18.9(r)-457.6(o)0(f)-441.3(m)0(a)12(c)0(r)19.2(o)0(p)15.5(h)0(a)20.8(g)0(e)-445.8(e)0(l)18.4(a)0(s)13.9(t)0(a)18.4(s)0(e)]TJ
-1.0015 -1.0527 TD
[(\(e)13.5(th)18.8(yl)18.9(en)15.1(e)-251.6(d)0(i)18.9(a)0(m)12(i)0(n)18.8(e)-251.6(te)12.8(tr)17.3(a)-251.6(a)0(c)14.7(e)0(t)18.4(i)0(c)-243.3(a)0(c)14.7(i)0(d)18.9(\))-252.7(an)15.1(d)-251.2(n)0(e)15.1(u)0(t)18.9(r)0(o)13.9(p)0(h)21.2(i)0(l)-245.3(e)0(l)18.4(a)0(s)13.9(t)0(a)18.4(s)0(e)]TJ
0 -1.0471 TD
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0 -1.0471 TD
(IL-1)Tj
/F7 1 Tf
1.7527 0 TD
(b)Tj
/F8 1 Tf
0.552 0 TD
[(,)-398.7(a)0(n)-7.6(other)-400.8(cytoki)-9.7(ne)-400.3(that)-400.9(is)-403.4(incre)-8.6(ased)-403.4(in)-402.3(obstructi)-11.5(ve)]TJ
-2.3047 -1.0527 TD
[(airways)-595.7(disea)-8.2(se)-583.6([40],)-592.8(does)-590.8(potentiat)-11.5(e)-587.3(the)-585.5(sti)-8.2(mulatory)]TJ
0 -1.0471 TD
[(effect)-409.7(of)-412.8(IL-17)-415.2(o)-6.5(n)-410.5(neutrop)-9.7(hil)-411.1(acti)-8.6(vation.)-414.2(It)-415.2(can)-418.5(be)-411.7(spe-)]TJ
0 -1.0528 TD
[(culate)-10.6(d)-399.1(that)-406.6(IL-17)-403.8(stimul)-10.4(ates)-405.8(the)-403.4(release)-404.8(of)-407.2(IL-1)]TJ
/F7 1 Tf
19.9283 0 TD
(b)Tj
/F8 1 Tf
0.9503 0 TD
(from)Tj
-20.8786 -1.0471 TD
[(airway)-394.6(macr)-8.6(ophages)-394.3(and)-389.7(that)-389.5(this)-396(IL-1)]TJ
/F7 1 Tf
15.9734 0 TD
(b)Tj
/F8 1 Tf
0.9389 0 TD
[(potent)-9.7(iates)-391.8(the)]TJ
-16.9123 -1.0527 TD
[(IL-17-i)-10.9(nduced)-358.2(relea)-9(se)-355.9(of)-355.9(IL-6)-357.5(a)-6.9(n)0(d)-354.3(IL8)-355.1(in)-356.7(bronchi)-9.7(al)-357.1(epi-)]TJ
0 -1.0471 TD
[(thelial)-340(cell)-8.6(s)-332([41,)-340(42].)]TJ
26.1993 45.4561 TD
[(Ev)17.1(en)-559.6(th)18.8(ou)21.2(gh)-559.2(it)-552.6(ha)15.1(s)-559.6(n)0(o)15.5(w)-562.4(be)15.1(en)-553.9(sh)14.4(ow)17.3(n)-564.1(t)0(h)18.9(a)0(t)-556.3(t)0(h)18.9(e)0(r)19.2(e)-564.5(is)]TJ
-1.0015 -1.0471 TD
[(in)13.2(cr)19.2(ea)14.7(se)19.6(d)-234.1(i)0(m)15.7(m)0(u)12.4(n)0(o)21.2(r)0(e)13.5(a)0(c)20.4(t)0(i)16.5(v)0(i)18.9(t)0(y)-231.5(f)0(o)19.6(r)-235.7(IL)15.5(-1)19.6(7)-239.8(i)0(n)-225.8(a)0(s)14(t)0(h)18.8(m)0(a)17.7(t)0(i)16.5(c)-240.2(ai)18.5(rw)15.7(ay)20.8(s)]TJ
0 -1.0528 TD
[([4)13.9(3],)-418.9(it)-427.4(is)-431.9(not)-431.5(know)-7(n)-427.6(whether)-435.2(this)-430.1(incre)-8.6(ased)-431.8(immunor-)]TJ
0 -1.0471 TD
[(eacti)-9.8(vity)-258.2(reflects)-261.2(the)-255.5(relea)-9(se)-253.5(of)-259.2(soluble)-256.4(b)-6.5(iologically)-265.8(active)]TJ
0 -1.0528 TD
[(IL)-7.2(-17)-305.5(from)-305.3(CD4+)-308.2(cell)-8.6(s)-303.6(i)0(n)-305.5(the)-301(airw)-11.4(ay)-303.5(wall)-308.1(and/or)-310.6(lumen.)]TJ
0 -1.0471 TD
[(Nei)-9(ther)-292(is)-295.3(it)-290.8(know)-7(n)-291(whether)-298.6(the)-295.3(associ)-10.1(ation)-293.5(of)-293.3(immunor-)]TJ
0 -1.0528 TD
[(eacti)-9.8(vity)-303.7(for)-301.4(IL)-7.2(-17)-299.8(and)-304.3(fibrotic)-307.1(areas)-309.4(in)-299.8(human)-309(bronchial)]TJ
0 -1.0471 TD
[(tis)-8.2(sue)-271.3(refl)-9(ects)-274.9(a)-274.3(role)-274.9(of)-276.3(IL-17)-278.6(in)-277.1(airway)-280.8(remodell)-10.7(ing)-272.1([43].)]TJ
0 -1.0527 TD
[(Y)92(e)0(t)-249(anothe)-7.8(r)-247.1(inte)-8.2(resting)-252.3(issue)-248(is)-249.8(whether)-253.1(n)-6.5(eutrophil)-255(activa-)]TJ
T*
[(tion)-372(an)-7.6(d)-365(recrui)-11(tment)-370.6(can)-373(account)-378.8(for)-369.7(the)-369.3(T)80.5(-lymphocyt)-11.8(e-)]TJ
0 -1.0471 TD
[(dep)-8.4(endent)-224(determin)-10.7(ation)-225.2(of)-219.4(airway)-229.5(responsiven)-9.9(ess)]TJ
/F3 1 Tf
20.1616 0 TD
[(in)-220.2(vivo)]TJ
/F8 1 Tf
-20.1616 -1.0528 TD
[([44],)-342.4(and)-332.7(whet)-9.8(her)-334.3(IL-17)-341.2(is)-335.1(involved)-341.3(in)-334(this)-339.1(contex)-7.8(t.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(e)-297.1(h)0(y)21.2(p)0(o)15.5(t)0(h)18.9(e)0(s)19.6(i)0(s)-289.6(t)13.9(ha)15.1(t)-293.4(i)0(n)18.9(t)0(e)18.4(r)0(l)17.3(e)0(u)15.1(k)0(i)18.9(n)0(-)13.9(1)0(7)-280.4(s)0(e)14(r)0(v)19.6(e)0(s)-282(a)0(s)-287.7(a)-291.4(me)12(di)18.9(at)18.5(or)]TJ
-1.0015 -1.0527 TD
[(li)16.5(nk)15.5(in)18.9(g)-296.7(t)0(h)18.9(e)-291.4(ac)14.7(ti)16.5(va)20.8(ti)16.5(on)-286.1(of)-287.7(ce)20.4(rt)17.3(ai)18.5(n)-296.7(C)0(D)18.3(4)0(+)-286.7(c)0(e)14.7(l)0(l)16.5(s)-292.2(to)-288.4(t)13.9(h)0(e)-286.5(r)0(e)13.5(c)0(r)19.2(u)0(i)18.9(t)0(-)]TJ
0 -1.0471 TD
[(me)12(nt)-407.9(an)15.1(d)-421.9(a)0(c)20.4(t)0(i)16.5(v)0(a)15.1(t)0(i)16.5(o)0(n)-411.3(o)0(f)-412.8(a)0(i)18.4(r)0(w)15.7(a)0(y)-411.7(n)0(e)15.1(u)0(t)18.9(r)0(o)19.6(p)0(h)15.5(i)0(l)16.5(s)-417.4(cl)12.8(ea)20.4(rl)17.3(y)-421.9(n)0(e)15.1(e)0(d)20.8(s)]TJ
0 -1.0527 TD
[(fu)13.9(rt)17.3(he)20.8(r)-338.1(e)0(v)20.8(a)0(l)12.8(u)0(a)20.8(t)0(i)16.5(o)0(n)15.5(.)-330.4(Ho)17.3(pe)15.1(fu)19.6(ll)16.5(y)73.2(,)-336.1(an)-326.3(in)18.9(cr)19.2(ea)14.7(se)19.6(d)-336.5(u)0(n)21.2(d)0(e)15.1(r)0(s)18.4(t)0(a)18.4(n)0(d)15.5(i)0(n)18.8(g)]TJ
0 -1.0471 TD
[(of)-270.6(th)18.9(es)13.9(e)-274.3(m)0(e)12(c)0(h)20.8(a)0(n)15.1(i)0(s)17.7(m)0(s)-267.6(w)0(i)14.9(l)0(l)-268.1(r)0(e)19.2(v)0(e)15.1(a)0(l)-266.1(n)0(o)15.5(v)0(e)15.1(l)-276.3(ta)18.4(r)20.4(g)0(e)15.1(t)0(s)-266.9(f)0(o)13.9(r)-275.5(ph)15.5(ar)19.2(ma)17.7(-)]TJ
0 -1.0528 TD
[(co)15.1(th)18.8(er)13.5(ap)20.8(eu)15.1(ti)16.5(ca)20.4(l)-492.5(i)0(n)18.9(t)0(e)18.4(r)0(v)13.9(e)0(n)20.8(t)0(i)16.5(o)0(n)-479.5(a)0(g)15.1(a)0(i)18.4(n)0(s)20(t)-492.5(ex)15.1(ag)20.8(ge)15.1(ra)19.2(te)18.4(d)-490.2(r)0(e)13.5(c)0(r)19.2(u)0(i)18.9(t)0(-)]TJ
0 -1.0471 TD
[(me)12(nt)-328.3(an)20.8(d)-336.5(a)0(c)14.7(t)13.9(iv)13.2(at)18.5(io)18.9(n)-336.5(o)0(f)-327.5(n)0(e)15.1(u)0(t)18.8(r)0(o)19.6(p)0(h)15.5(i)0(l)16.5(s)-332(in)-328.3(ob)15.5(st)17.7(ru)19.6(ct)18.5(iv)13.2(e)-336.9(a)0(i)18.5(r)0(w)15.7(a)0(y)20.8(s)]TJ
0 -1.0527 TD
[(di)13.2(se)19.6(as)19.6(e.)]TJ
/F5 1 Tf
8.966 0 0 8.966 402.349 541.417 Tm
[(Refer)11.6(ences)]TJ
/F8 1 Tf
-10.3759 -2.2762 TD
[(1.)-1766.5(Fahy)-590.7(JV)129.3(,)-590.9(Kim)-594.1(KW)87(,)-590.9(Liu)-586.1(J,)-591.6(Boushey)-590.1(HA.)-590.2(Prominent)]TJ
2.5165 -1.1128 TD
[(neutrophilic)-364.3(inflammation)-361.8(in)-361.8(sputum)-362.8(from)-362.2(subjects)-363(with)]TJ
T*
[(asthma)-311.8(excacerbation.)]TJ
/F3 1 Tf
9.1619 0 TD
[(J)-315.4(Aller)31.3(gy)-314.9(Clin)-317.3(Immunol)]TJ
/F8 1 Tf
9.8068 0 TD
[(1995;)-309.7(95:)]TJ
-18.9687 -1.1065 TD
(843\261852.)Tj
-2.5165 -1.1128 TD
[(2.)-1766.5(Laitinen)-448.7(LA,)-451.3(Laitinen)-448.7(A,)-448.3(Haahtela)-452(T)72.9(.)-451.8(Airway)-449.3(mucosal)]TJ
2.5165 -1.1128 TD
[(inflammation)-602(even)-591.9(in)-595.7(patients)-598.2(with)-594.1(newly)-597.3(diagnosed)]TJ
T*
(asthma.)Tj
/F3 1 Tf
3.3828 0 TD
[(Am)-334.6(Rev)-336.6(Respir)-333.8(Dis)]TJ
/F8 1 Tf
8.0933 0 TD
[(1993;)-334.9(147:)-329.1(697\261704.)]TJ
-13.9926 -1.1065 TD
[(3.)-1766.5(Nocker)-247.3(RET)72(,)-249.5(Schoonbrood)-246.6(DFM,)-244.2(van)-244.9(de)-251.7(Graaf)-248.8(EA,)]TJ
/F3 1 Tf
23.3632 0 TD
[(et)-247.7(al)]TJ
/F8 1 Tf
1.7262 0 TD
(.)Tj
-22.5728 -1.1128 TD
[(Interleukin-8)-553.1(in)-545.2(airway)-553.2(inflammation)-551.4(in)-545.2(patients)-553.9(with)]TJ
T*
[(asthma)-457.2(and)-453.5(chronic)-454.6(obstructive)-458.5(pulmonary)-455.7(disease.)]TJ
/F3 1 Tf
21.7255 0 TD
(Int)Tj
-21.7255 -1.1128 TD
[(Ar)34.3(ch)-333.9(Aller)24.9(gy)-333.9(Immunol)]TJ
/F8 1 Tf
9.301 0 TD
[(1996;)-328.6(109:)-335.5(183\261191.)]TJ
-11.8175 -1.1065 TD
[(4.)-1766.5(Saetta)-435.9(M,)-433(T)34.9(urato)-436.9(G,)-429.3(Facchini)-434.9(FM,)]TJ
/F3 1 Tf
17.3185 0 TD
[(et)-431.1(al)]TJ
/F8 1 Tf
1.9095 0 TD
[(.)-432.9(Inflammatory)]TJ
-16.7115 -1.1128 TD
[(cells)-369.7(in)-361.8(bronchial)-367.4(glands)-367(of)-366.7(smokers)-368.2(with)-366.4(chronic)-366.1(bron-)]TJ
T*
(chitis.)Tj
/F3 1 Tf
2.605 0 TD
[(Am)-220.8(J)-220.6(Respir)-226.3(Crit)-223.6(Car)33.6(e)-226.9(Med)]TJ
/F8 1 Tf
10.9829 0 TD
[(1997;)-221.1(156:)-221.6(1633\2611639.)]TJ
-16.1045 -1.1065 TD
[(5.)-1766.5(Hamid)-283(Q,)-277.6(Song)-281.1(Y)130(,)-281.1(Kotsimbos)-285.9(TC,)]TJ
/F3 1 Tf
16.5723 0 TD
[(et)-279.4(al)]TJ
/F8 1 Tf
1.7578 0 TD
[(.)-281.1(Inflammation)-284.5(of)]TJ
-15.8136 -1.1128 TD
[(small)-371.8(airways)-376.9(in)-368.1(asthma.)]TJ
/F3 1 Tf
10.515 0 TD
[(J)-372.3(Aller)31.3(gy)-371.8(Clin)-374.2(Immunol)]TJ
/F8 1 Tf
10.0345 0 TD
(1997;)Tj
-20.5495 -1.1128 TD
[(100:)-335.5(44\26151.)]TJ
-2.5165 -1.1128 TD
[(6.)-1766.5(Lamblin)-404.7(C,)-405.5(Gosset)-403.1(P)103.1(,)-401.3(T)34.9(illie-Leblond)-407.6(I,)]TJ
/F3 1 Tf
18.8992 0 TD
[(et)-399.5(al)]TJ
/F8 1 Tf
1.8779 0 TD
[(.)-401.3(Bronchial)]TJ
-18.2606 -1.1065 TD
[(neutrophilia)-282.1(in)-279.6(patients)-282(with)-277.9(noninfectious)-280.4(status)-282.1(asthma-)]TJ
0 -1.1128 TD
(ticus.)Tj
/F3 1 Tf
2.447 0 TD
[(Am)-334.6(J)-334.4(Respir)-333.8(Crit)-331.1(Car)27.2(e)-334.4(Med)]TJ
/F8 1 Tf
11.6531 0 TD
[(1998;)-334.9(157:)-329.1(394\261402.)]TJ
-16.6166 -1.1128 TD
[(7.)-1766.5(Cortijo)-281.2(J,)-281.8(V)47.8(illagrasa)-282.2(V)123.6(,)-281.1(Pons)-276(R,)]TJ
/F3 1 Tf
15.3331 0 TD
[(et)-279.4(al)]TJ
/F8 1 Tf
1.7578 0 TD
[(.)-281.1(Bronchodilator)-284.4(and)]TJ
-14.5743 -1.1128 TD
[(anti-inflammatory)-388.6(activities)-386.7(of)-385.7(glaucine:)]TJ
/F3 1 Tf
16.7051 0 TD
[(in)-380.8(vitr)27.9(o)]TJ
/F8 1 Tf
3.3638 0 TD
(studies)Tj
-20.0689 -1.1065 TD
[(on)-245.6(human)-252(airway)-249.7(smooth)-249(muscle)-254.9(and)-244.9(polymorphonuclear)]TJ
0 -1.1128 TD
(leukocytes.)Tj
/F3 1 Tf
4.8181 0 TD
[(Br)-338.8(J)-328.1(Pharmacol)]TJ
/F8 1 Tf
6.8477 0 TD
[(1999;)-328.6(127:)-335.5(1641\2611651.)]TJ
-14.1823 -1.1128 TD
[(8.)-1766.5(Nadel)-299.9(JA,)-297.2(Stockley)-296(RA.)-294.4(Proteolytic)-306.5(enzymes)-296(and)-295.4(airway)]TJ
2.5165 -1.1128 TD
(diseases.)Tj
/F3 1 Tf
3.819 0 TD
[(Eur)-338.3(Respir)-333.8(J)]TJ
/F8 1 Tf
5.5136 0 TD
[(1998;)-328.6(12:)-336(1250\2611251.)]TJ
-11.8491 -1.1065 TD
[(9.)-1766.5(Schuster)-453.8(A,)-454.6(Ueki)-452.3(I,)-458.6(Nadel)-451.6(JA.)-455.3(Neutrophil)-455(elastase)-457.4(sti-)]TJ
2.5165 -1.1128 TD
[(mulates)-313.6(tracheal)-316.9(submucosal)-310.9(gland)-315.8(secretion)-311.5(that)-312.3(is)-312.4(inhi-)]TJ
T*
[(bited)-254.9(by)-258.2(ICI)-258(200,355.)]TJ
/F3 1 Tf
8.8141 0 TD
[(Am)-258.7(J)-252.2(Physiol)]TJ
/F8 1 Tf
5.4946 0 TD
[(1992;)-259.1(262:)-253.3(L86\261L91.)]TJ
-16.8253 -1.1065 TD
[(10.)-1266.5(V)54.1(ignola)-368.2(AM,)-372.6(Bonanno)-367.6(A,)-366.1(Mirabella)-370.3(A,)]TJ
/F3 1 Tf
19.0889 0 TD
[(et)-374.2(al)]TJ
/F8 1 Tf
1.8463 0 TD
[(.)-369.6(Increased)]TJ
-18.4186 -1.1128 TD
[(level)-216.7(of)-214.9(elastase)-217.1(and)]TJ
/F7 1 Tf
8.0997 0 TD
(a)Tj
/F8 1 Tf
6.725 0 0 5.977 410.173 220.649 Tm
(1)Tj
8.966 0 0 8.966 413.575 222.123 Tm
[(-antitrypsin)-215(in)-216.4(sputum)-217.4(of)-214.9(asthmatic)]TJ
-9.1113 -1.1128 TD
(patients.)Tj
/F3 1 Tf
3.5535 0 TD
[(Am)-233.4(J)-233.2(Respir)-232.6(Crit)-229.9(Car)27.2(e)-233.2(Med)]TJ
/F8 1 Tf
11.0461 0 TD
[(1998;)-227.5(157:)-234.3(505\26151)34.7(1.)]TJ
-17.1161 -1.1128 TD
[(1)25.8(1)0(.)-1292.3(W)70.8(atanabe)-548(M,)-553.2(Kaihatsu)-554.8(T)72.9(,)-546.7(Miwa)-554.2(M,)-546.9(Maeda)-553.9(T)72.9(.)-546.7(Ca)]TJ
6.725 0 0 5.977 526.904 206.192 Tm
0.0001 Tc
(2+)Tj
8.966 0 0 8.966 534.047 202.167 Tm
0 Tc
(/)Tj
-22.5475 -1.1065 TD
[(calmodulin-dependent)-336.1(protein)-337.1(kinase)-328.9(II)-336(inhibitors)-335.4(poten-)]TJ
0 -1.1128 TD
[(tiate)-282.4(superoxide)-283.5(production)-284.9(in)-279.6(polymorphonuclear)-290.1(leuko-)]TJ
T*
(cytes.)Tj
/F3 1 Tf
2.6114 0 TD
[(J)-334.4(Pharm)-334.2(Pharmacol)]TJ
/F8 1 Tf
8.5612 0 TD
[(1999;)-334.9(51:)-329.7(295\261300.)]TJ
-13.6891 -1.1128 TD
[(12.)-1266.5(Massion)-355.7(P)103.1(,)-357(Linde)]TJ
9.2314 0.0443 TD
(\302)Tj
0.3731 -0.0443 TD
[(n)-353.6(A)0(,)-359.8(Inoue)-358.6(H,)-353.5(Mathy)-360.7(M,)-357.2(Grattan)-359.1(KM,)]TJ
-7.088 -1.1065 TD
[(Nadel)-495.9(JA.)-493.2(Dimethyl)-501.2(sulfoxide)-495.3(decreases)-497.1(interleukin-8-)]TJ
0 -1.1128 TD
[(mediated)-507.7(neutrophil)-502.3(recruitment)-510.5(in)-500.9(the)-506.5(airways.)]TJ
/F3 1 Tf
20.5558 0 TD
[(Am)-505.3(J)]TJ
-20.5558 -1.1128 TD
(Physiol)Tj
/F8 1 Tf
3.3006 0 TD
[(1996;)-334.9(271:)-329.1(L838\261L843.)]TJ
-5.8171 -1.1065 TD
[(13.)-1266.5(Jorens)-373.1(PG,)-376.8(Richman-Eisenstadt)-379.6(JBY)125.1(,)-376(Housset)-377.3(BP)105.2(,)]TJ
/F3 1 Tf
23.2367 0 TD
[(et)-374.2(al)]TJ
/F8 1 Tf
1.8526 0 TD
(.)Tj
-22.5728 -1.1128 TD
[(Interleukin-8)-540.4(induces)-543.3(neutrophil)-540.2(accumulation)-539.4(but)-538.3(not)]TJ
ET
0 0 0 0.3 k
0 0 0 1 K
0 J 0 j 0.5 w 3.864 M []0 d
/GS3 gs
1 i 
99.128 144.193 m
92.878 145.818 l
93.378 142.193 l
98.253 142.068 l
99.128 144.193 l
b
124.877 143.818 m
116.753 145.443 112.877 145.568 v
109.003 145.693 105.253 146.068 102.753 145.568 c
100.253 145.068 99.128 144.693 98.878 143.943 c
98.628 143.193 98.128 141.943 y
125.003 141.943 l
124.877 143.818 l
b
152.127 143.693 m
146.127 145.693 142.252 145.568 v
138.377 145.443 131.627 145.318 y
125.378 144.443 125.003 143.943 v
124.628 143.443 125.003 142.193 y
152.127 141.818 l
152.127 143.693 l
b
152.002 143.943 m
158.127 145.693 164.877 145.318 v
171.627 144.943 175.002 144.068 y
178.877 142.068 l
152.127 141.818 l
152.002 143.943 l
b
176.877 142.193 m
177.752 144.318 182.627 144.818 v
187.502 145.318 192.002 145.443 y
197.252 145.193 199.002 144.693 v
200.752 144.193 203.502 144.068 y
204.502 142.318 l
184.752 142.068 l
176.877 142.193 l
b
225.377 141.818 m
225.252 145.318 l
211.877 145.568 211.002 145.568 v
210.127 145.568 207.127 145.568 206.252 144.693 c
205.377 143.818 204.627 142.568 204.627 142.068 c
204.627 141.568 225.377 141.818 y
b
225.502 188.318 m
225.502 184.568 l
216.252 184.568 215.627 186.693 v
215.002 188.818 217.127 188.318 y
225.502 188.318 l
b
190.002 187.943 m
190.877 185.193 200.252 184.693 v
209.627 184.193 212.502 185.193 y
216.252 186.193 216.127 187.943 v
216.002 189.693 213.127 188.318 y
190.002 187.943 l
b
163.127 188.068 m
161.127 187.068 165.252 185.693 v
169.377 184.318 174.502 184.443 177.127 184.693 c
179.752 184.943 185.252 185.443 186.752 185.818 c
188.252 186.193 189.627 187.443 y
190.002 188.318 l
163.127 188.068 l
b
137.877 188.193 m
136.252 186.443 145.502 185.193 v
154.752 183.943 158.127 185.193 y
161.877 185.818 162.377 186.443 v
162.877 187.068 163.252 188.318 y
137.877 188.193 l
b
110.253 188.068 m
109.003 187.318 111.628 186.193 v
114.253 185.068 118.253 185.193 123.878 185.193 c
129.502 185.193 136.377 186.193 137.252 186.818 c
138.127 187.443 137.627 188.193 y
110.253 188.068 l
b
93.128 188.318 m
93.128 185.443 l
103.753 186.068 109.628 188.068 v
115.502 190.068 105.628 188.443 y
93.128 188.318 l
b
2 w 
81.503 215.443 m
98.878 215.443 l
S
0 0 0 1 k
98.211 215.443 m
98.211 219.443 l
108.211 215.443 l
98.211 211.443 l
98.211 215.443 l
f*
0.25 w 
170.093 264.562 m
170.093 264.769 170.457 264.937 170.905 264.937 c
171.354 264.937 171.718 264.769 171.718 264.562 c
171.718 264.355 171.354 264.187 170.905 264.187 c
170.457 264.187 170.093 264.355 170.093 264.562 c
b
171.655 260.562 m
171.655 260.769 172.019 260.937 172.468 260.937 c
172.916 260.937 173.28 260.769 173.28 260.562 c
173.28 260.355 172.916 260.187 172.468 260.187 c
172.019 260.187 171.655 260.355 171.655 260.562 c
b
173.28 257.25 m
173.28 257.457 173.644 257.625 174.093 257.625 c
174.542 257.625 174.905 257.457 174.905 257.25 c
174.905 257.043 174.542 256.875 174.093 256.875 c
173.644 256.875 173.28 257.043 173.28 257.25 c
b
171.155 255.5 m
171.155 255.707 171.519 255.875 171.968 255.875 c
172.417 255.875 172.78 255.707 172.78 255.5 c
172.78 255.292 172.417 255.125 171.968 255.125 c
171.519 255.125 171.155 255.292 171.155 255.5 c
b
0 0 0 0 k
0.5 w 
145.468 257.437 m
145.468 263.892 151.932 269.125 159.905 269.125 c
167.879 269.125 174.343 263.892 174.343 257.437 c
174.343 250.982 167.879 245.75 159.905 245.75 c
151.932 245.75 145.468 250.982 145.468 257.437 c
b
1 w 
91.128 302.875 m
225.502 302.875 l
S
0.5 w 
219.627 291.942 m
221.502 289.817 223.627 292.567 v
225.752 295.317 225.752 296.567 225.627 298.442 c
225.502 300.317 225.002 302.692 y
213.377 292.817 m
215.502 289.817 218.252 291.192 v
221.002 292.567 220.002 294.692 220.252 296.567 c
220.502 298.442 219.502 302.817 y
206.252 292.817 m
206.502 291.192 209.627 290.942 v
212.752 290.692 213.377 291.942 213.627 293.942 c
213.877 295.942 213.127 302.567 y
198.877 292.942 m
199.752 291.317 201.752 291.067 v
203.752 290.817 206.002 291.442 206.252 293.692 c
206.502 295.942 206.252 298.442 y
205.377 301.942 205.752 302.567 v
192.002 292.317 m
193.127 290.942 195.127 290.942 v
197.127 290.942 198.502 291.817 198.877 293.692 c
199.252 295.567 198.502 299.067 y
198.252 302.442 l
184.752 292.567 m
185.127 290.567 188.002 290.817 v
190.877 291.067 192.127 291.942 192.252 293.942 c
192.377 295.942 191.877 302.692 y
177.127 292.817 m
177.752 291.067 179.877 290.942 v
182.002 290.817 184.502 291.192 184.627 293.442 c
184.752 295.692 184.252 302.567 y
170.752 292.317 m
171.752 290.567 173.877 290.817 v
176.002 291.067 177.252 291.817 177.252 293.817 c
177.252 295.817 176.502 302.692 y
163.377 292.692 m
165.002 290.817 167.377 290.817 v
169.752 290.817 170.877 291.817 170.877 293.567 c
170.877 295.317 170.627 302.817 y
156.252 292.817 m
156.627 290.942 158.252 290.817 v
159.877 290.692 161.127 290.692 y
163.002 291.567 163.252 293.817 v
163.502 296.067 162.877 302.692 y
149.127 292.817 m
151.252 290.817 152.377 290.942 v
153.502 291.067 155.752 291.317 156.002 293.692 c
156.252 296.067 155.377 302.442 y
141.752 292.692 m
142.377 290.817 144.752 291.067 v
147.127 291.317 149.252 290.942 149.127 293.942 c
149.002 296.942 149.002 302.942 y
134.377 293.317 m
134.627 290.942 136.627 291.067 v
138.627 291.192 141.752 290.692 141.752 293.817 c
141.752 296.942 141.627 298.317 y
141.377 302.317 l
127.502 293.067 m
128.377 291.442 130.502 291.442 v
132.627 291.442 134.252 292.317 134.377 293.692 c
134.502 295.067 134.127 298.567 y
134.002 302.442 l
120.377 293.067 m
120.752 291.692 122.378 291.442 v
124.002 291.192 125.378 291.317 y
127.627 292.192 127.752 293.817 v
127.877 295.442 127.627 302.442 y
112.628 293.317 m
113.753 291.567 115.127 291.317 v
116.503 291.067 120.377 291.567 120.252 293.817 c
120.128 296.067 120.002 301.817 119.753 302.317 c
106.128 293.442 m
107.753 290.817 109.128 291.317 v
110.503 291.817 113.128 292.692 112.753 295.317 c
112.378 297.942 112.378 302.692 y
98.878 293.317 m
100.253 291.442 101.878 291.442 v
103.503 291.442 106.128 292.067 106.253 294.942 c
106.378 297.817 106.003 302.567 y
91.128 302.317 m
90.878 299.192 91.253 297.817 v
91.628 296.442 91.378 293.192 91.878 292.692 c
92.378 292.192 93.128 291.942 94.753 291.817 c
96.378 291.692 99.003 292.567 98.878 294.192 c
98.753 295.817 99.003 299.067 y
97.878 301.817 98.503 302.567 v
S
BT
/F15 1 Tf
10 0 0 10 95.003 278.776 Tm
0 0 0 1 k
/GS4 gs
(Bronchiole)Tj
ET
0 0 0 0 k
/GS3 gs
151.377 278.13 m
151.377 284.585 157.841 289.817 165.815 289.817 c
173.788 289.817 180.252 284.585 180.252 278.13 c
180.252 271.675 173.788 266.442 165.815 266.442 c
157.841 266.442 151.377 271.675 151.377 278.13 c
b
177.377 260.38 m
177.377 266.835 183.841 272.067 191.815 272.067 c
199.788 272.067 206.252 266.835 206.252 260.38 c
206.252 253.925 199.788 248.692 191.815 248.692 c
183.841 248.692 177.377 253.925 177.377 260.38 c
b
0 0 0 1 k
155.877 281.442 m
155.877 283.928 157.78 285.942 160.127 285.942 c
162.474 285.942 164.377 283.928 164.377 281.442 c
164.377 278.957 162.474 276.942 160.127 276.942 c
157.78 276.942 155.877 278.957 155.877 281.442 c
b
171.627 278.067 m
171.627 280.414 173.082 282.317 174.877 282.317 c
176.672 282.317 178.127 280.414 178.127 278.067 c
178.127 275.72 176.672 273.818 174.877 273.818 c
173.082 273.818 171.627 275.72 171.627 278.067 c
b
160.752 276.255 m
160.752 278.222 161.872 279.817 163.252 279.817 c
164.633 279.817 165.752 278.222 165.752 276.255 c
165.752 274.287 164.633 272.693 163.252 272.693 c
161.872 272.693 160.752 274.287 160.752 276.255 c
b
165.252 274.442 m
165.252 277.066 167.239 279.192 169.69 279.192 c
172.14 279.192 174.127 277.066 174.127 274.442 c
174.127 271.819 172.14 269.693 169.69 269.693 c
167.239 269.693 165.252 271.819 165.252 274.442 c
b
163.502 272.942 m
163.502 274.599 164.845 275.942 166.502 275.942 c
168.159 275.942 169.502 274.599 169.502 272.942 c
169.502 271.286 168.159 269.942 166.502 269.942 c
164.845 269.942 163.502 271.286 163.502 272.942 c
b
182.002 263.693 m
182.002 266.178 183.905 268.193 186.252 268.193 c
188.599 268.193 190.502 266.178 190.502 263.693 c
190.502 261.207 188.599 259.193 186.252 259.193 c
183.905 259.193 182.002 261.207 182.002 263.693 c
b
197.752 260.318 m
197.752 262.665 199.207 264.567 201.002 264.567 c
202.797 264.567 204.252 262.665 204.252 260.318 c
204.252 257.97 202.797 256.068 201.002 256.068 c
199.207 256.068 197.752 257.97 197.752 260.318 c
b
186.877 258.505 m
186.877 260.472 187.996 262.068 189.377 262.068 c
190.758 262.068 191.877 260.472 191.877 258.505 c
191.877 256.537 190.758 254.943 189.377 254.943 c
187.996 254.943 186.877 256.537 186.877 258.505 c
b
191.377 256.692 m
191.377 259.316 193.364 261.443 195.815 261.443 c
198.265 261.443 200.252 259.316 200.252 256.692 c
200.252 254.069 198.265 251.943 195.815 251.943 c
193.364 251.943 191.377 254.069 191.377 256.692 c
b
189.627 255.192 m
189.627 256.849 190.97 258.192 192.627 258.192 c
194.284 258.192 195.627 256.849 195.627 255.192 c
195.627 253.536 194.284 252.192 192.627 252.192 c
190.97 252.192 189.627 253.536 189.627 255.192 c
b
150.093 260.75 m
150.093 263.235 151.996 265.25 154.343 265.25 c
156.69 265.25 158.593 263.235 158.593 260.75 c
158.593 258.265 156.69 256.25 154.343 256.25 c
151.996 256.25 150.093 258.265 150.093 260.75 c
b
165.843 257.375 m
165.843 259.722 167.298 261.625 169.093 261.625 c
170.888 261.625 172.343 259.722 172.343 257.375 c
172.343 255.028 170.888 253.125 169.093 253.125 c
167.298 253.125 165.843 255.028 165.843 257.375 c
b
154.968 255.562 m
154.968 257.53 156.087 259.125 157.468 259.125 c
158.849 259.125 159.968 257.53 159.968 255.562 c
159.968 253.595 158.849 252 157.468 252 c
156.087 252 154.968 253.595 154.968 255.562 c
b
159.468 253.75 m
159.468 256.373 161.454 258.5 163.905 258.5 c
166.356 258.5 168.343 256.373 168.343 253.75 c
168.343 251.126 166.356 249 163.905 249 c
161.454 249 159.468 251.126 159.468 253.75 c
b
157.718 252.25 m
157.718 253.907 159.061 255.25 160.718 255.25 c
162.375 255.25 163.718 253.907 163.718 252.25 c
163.718 250.593 162.375 249.25 160.718 249.25 c
159.061 249.25 157.718 250.593 157.718 252.25 c
b
0.25 w 
147.627 284.942 m
147.627 285.149 147.991 285.317 148.44 285.317 c
148.889 285.317 149.252 285.149 149.252 284.942 c
149.252 284.735 148.889 284.567 148.44 284.567 c
147.991 284.567 147.627 284.735 147.627 284.942 c
b
145.94 283.88 m
145.94 284.087 146.304 284.255 146.752 284.255 c
147.201 284.255 147.565 284.087 147.565 283.88 c
147.565 283.673 147.201 283.505 146.752 283.505 c
146.304 283.505 145.94 283.673 145.94 283.88 c
b
144.002 282.692 m
144.002 282.899 144.366 283.067 144.815 283.067 c
145.264 283.067 145.627 282.899 145.627 282.692 c
145.627 282.485 145.264 282.317 144.815 282.317 c
144.366 282.317 144.002 282.485 144.002 282.692 c
b
146.377 281.005 m
146.377 281.212 146.741 281.38 147.19 281.38 c
147.639 281.38 148.002 281.212 148.002 281.005 c
148.002 280.798 147.639 280.63 147.19 280.63 c
146.741 280.63 146.377 280.798 146.377 281.005 c
b
148.877 281.755 m
148.877 281.962 149.241 282.13 149.69 282.13 c
150.139 282.13 150.502 281.962 150.502 281.755 c
150.502 281.548 150.139 281.38 149.69 281.38 c
149.241 281.38 148.877 281.548 148.877 281.755 c
b
151.315 281.005 m
151.315 281.212 151.679 281.38 152.127 281.38 c
152.576 281.38 152.94 281.212 152.94 281.005 c
152.94 280.798 152.576 280.63 152.127 280.63 c
151.679 280.63 151.315 280.798 151.315 281.005 c
b
149.627 279.88 m
149.627 280.087 149.991 280.255 150.44 280.255 c
150.889 280.255 151.252 280.087 151.252 279.88 c
151.252 279.673 150.889 279.505 150.44 279.505 c
149.991 279.505 149.627 279.673 149.627 279.88 c
b
147.127 279.692 m
147.127 279.899 147.491 280.067 147.94 280.067 c
148.389 280.067 148.752 279.899 148.752 279.692 c
148.752 279.485 148.389 279.317 147.94 279.317 c
147.491 279.317 147.127 279.485 147.127 279.692 c
b
148.002 278.63 m
148.002 278.837 148.366 279.005 148.815 279.005 c
149.264 279.005 149.627 278.837 149.627 278.63 c
149.627 278.423 149.264 278.255 148.815 278.255 c
148.366 278.255 148.002 278.423 148.002 278.63 c
b
145.565 278.693 m
145.565 278.899 145.929 279.068 146.377 279.068 c
146.826 279.068 147.19 278.899 147.19 278.693 c
147.19 278.485 146.826 278.318 146.377 278.318 c
145.929 278.318 145.565 278.485 145.565 278.693 c
b
144.002 277.63 m
144.002 277.837 144.366 278.005 144.815 278.005 c
145.264 278.005 145.627 277.837 145.627 277.63 c
145.627 277.423 145.264 277.255 144.815 277.255 c
144.366 277.255 144.002 277.423 144.002 277.63 c
b
142.44 276.317 m
142.44 276.525 142.804 276.692 143.252 276.692 c
143.701 276.692 144.065 276.525 144.065 276.317 c
144.065 276.11 143.701 275.942 143.252 275.942 c
142.804 275.942 142.44 276.11 142.44 276.317 c
b
144.565 274.63 m
144.565 274.837 144.929 275.005 145.377 275.005 c
145.826 275.005 146.19 274.837 146.19 274.63 c
146.19 274.423 145.826 274.255 145.377 274.255 c
144.929 274.255 144.565 274.423 144.565 274.63 c
b
145.065 273.63 m
145.065 273.837 145.429 274.005 145.877 274.005 c
146.326 274.005 146.69 273.837 146.69 273.63 c
146.69 273.423 146.326 273.255 145.877 273.255 c
145.429 273.255 145.065 273.423 145.065 273.63 c
b
147.19 275.38 m
147.19 275.587 147.554 275.755 148.002 275.755 c
148.451 275.755 148.815 275.587 148.815 275.38 c
148.815 275.173 148.451 275.005 148.002 275.005 c
147.554 275.005 147.19 275.173 147.19 275.38 c
b
150.44 277.005 m
150.44 277.212 150.804 277.38 151.252 277.38 c
151.701 277.38 152.065 277.212 152.065 277.005 c
152.065 276.798 151.701 276.63 151.252 276.63 c
150.804 276.63 150.44 276.798 150.44 277.005 c
b
150.752 275.817 m
150.752 276.024 151.116 276.192 151.565 276.192 c
152.014 276.192 152.377 276.024 152.377 275.817 c
152.377 275.61 152.014 275.442 151.565 275.442 c
151.116 275.442 150.752 275.61 150.752 275.817 c
b
152.94 277.88 m
152.94 278.087 153.304 278.255 153.752 278.255 c
154.201 278.255 154.565 278.087 154.565 277.88 c
154.565 277.673 154.201 277.505 153.752 277.505 c
153.304 277.505 152.94 277.673 152.94 277.88 c
b
155.19 277.067 m
155.19 277.275 155.554 277.442 156.002 277.442 c
156.451 277.442 156.815 277.275 156.815 277.067 c
156.815 276.86 156.451 276.692 156.002 276.692 c
155.554 276.692 155.19 276.86 155.19 277.067 c
b
158.002 276.192 m
158.002 276.399 158.366 276.567 158.815 276.567 c
159.264 276.567 159.627 276.399 159.627 276.192 c
159.627 275.985 159.264 275.817 158.815 275.817 c
158.366 275.817 158.002 275.985 158.002 276.192 c
b
159.252 274.943 m
159.252 275.149 159.616 275.318 160.065 275.318 c
160.513 275.318 160.877 275.149 160.877 274.943 c
160.877 274.735 160.513 274.568 160.065 274.568 c
159.616 274.568 159.252 274.735 159.252 274.943 c
b
160.502 273.38 m
160.502 273.587 160.866 273.755 161.315 273.755 c
161.764 273.755 162.127 273.587 162.127 273.38 c
162.127 273.173 161.764 273.005 161.315 273.005 c
160.866 273.005 160.502 273.173 160.502 273.38 c
b
156.877 274.005 m
156.877 274.212 157.241 274.38 157.69 274.38 c
158.139 274.38 158.502 274.212 158.502 274.005 c
158.502 273.798 158.139 273.63 157.69 273.63 c
157.241 273.63 156.877 273.798 156.877 274.005 c
b
156.69 272.505 m
156.69 272.712 157.054 272.88 157.502 272.88 c
157.951 272.88 158.315 272.712 158.315 272.505 c
158.315 272.298 157.951 272.13 157.502 272.13 c
157.054 272.13 156.69 272.298 156.69 272.505 c
b
154.44 272.005 m
154.44 272.212 154.804 272.38 155.252 272.38 c
155.701 272.38 156.065 272.212 156.065 272.005 c
156.065 271.798 155.701 271.63 155.252 271.63 c
154.804 271.63 154.44 271.798 154.44 272.005 c
b
154.065 273.13 m
154.065 273.337 154.429 273.505 154.877 273.505 c
155.326 273.505 155.69 273.337 155.69 273.13 c
155.69 272.923 155.326 272.755 154.877 272.755 c
154.429 272.755 154.065 272.923 154.065 273.13 c
b
151.815 274.755 m
151.815 274.962 152.179 275.13 152.627 275.13 c
153.076 275.13 153.44 274.962 153.44 274.755 c
153.44 274.548 153.076 274.38 152.627 274.38 c
152.179 274.38 151.815 274.548 151.815 274.755 c
b
153.69 276.13 m
153.69 276.337 154.054 276.505 154.502 276.505 c
154.951 276.505 155.315 276.337 155.315 276.13 c
155.315 275.923 154.951 275.755 154.502 275.755 c
154.054 275.755 153.69 275.923 153.69 276.13 c
b
158.69 271.38 m
158.69 271.587 159.054 271.755 159.502 271.755 c
159.951 271.755 160.315 271.587 160.315 271.38 c
160.315 271.173 159.951 271.005 159.502 271.005 c
159.054 271.005 158.69 271.173 158.69 271.38 c
b
158.377 270.13 m
158.377 270.337 158.741 270.505 159.19 270.505 c
159.639 270.505 160.002 270.337 160.002 270.13 c
160.002 269.923 159.639 269.755 159.19 269.755 c
158.741 269.755 158.377 269.923 158.377 270.13 c
b
141.814 264.17 m
141.814 264.378 142.178 264.545 142.626 264.545 c
143.075 264.545 143.439 264.378 143.439 264.17 c
143.439 263.963 143.075 263.795 142.626 263.795 c
142.178 263.795 141.814 263.963 141.814 264.17 c
b
140.126 263.108 m
140.126 263.315 140.49 263.483 140.939 263.483 c
141.388 263.483 141.751 263.315 141.751 263.108 c
141.751 262.901 141.388 262.733 140.939 262.733 c
140.49 262.733 140.126 262.901 140.126 263.108 c
b
138.189 261.92 m
138.189 262.128 138.553 262.295 139.001 262.295 c
139.45 262.295 139.814 262.128 139.814 261.92 c
139.814 261.713 139.45 261.545 139.001 261.545 c
138.553 261.545 138.189 261.713 138.189 261.92 c
b
140.564 260.233 m
140.564 260.44 140.928 260.608 141.376 260.608 c
141.825 260.608 142.189 260.44 142.189 260.233 c
142.189 260.026 141.825 259.858 141.376 259.858 c
140.928 259.858 140.564 260.026 140.564 260.233 c
b
143.064 260.983 m
143.064 261.19 143.428 261.358 143.876 261.358 c
144.325 261.358 144.689 261.19 144.689 260.983 c
144.689 260.776 144.325 260.608 143.876 260.608 c
143.428 260.608 143.064 260.776 143.064 260.983 c
b
145.501 260.233 m
145.501 260.44 145.865 260.608 146.314 260.608 c
146.763 260.608 147.126 260.44 147.126 260.233 c
147.126 260.026 146.763 259.858 146.314 259.858 c
145.865 259.858 145.501 260.026 145.501 260.233 c
b
143.814 259.108 m
143.814 259.315 144.178 259.483 144.626 259.483 c
145.075 259.483 145.439 259.315 145.439 259.108 c
145.439 258.901 145.075 258.733 144.626 258.733 c
144.178 258.733 143.814 258.901 143.814 259.108 c
b
141.314 258.921 m
141.314 259.128 141.678 259.296 142.126 259.296 c
142.575 259.296 142.939 259.128 142.939 258.921 c
142.939 258.713 142.575 258.546 142.126 258.546 c
141.678 258.546 141.314 258.713 141.314 258.921 c
b
142.189 257.858 m
142.189 258.065 142.553 258.233 143.001 258.233 c
143.45 258.233 143.814 258.065 143.814 257.858 c
143.814 257.651 143.45 257.483 143.001 257.483 c
142.553 257.483 142.189 257.651 142.189 257.858 c
b
139.751 257.921 m
139.751 258.128 140.115 258.296 140.564 258.296 c
141.013 258.296 141.376 258.128 141.376 257.921 c
141.376 257.714 141.013 257.546 140.564 257.546 c
140.115 257.546 139.751 257.714 139.751 257.921 c
b
138.189 256.858 m
138.189 257.065 138.553 257.233 139.001 257.233 c
139.45 257.233 139.814 257.065 139.814 256.858 c
139.814 256.651 139.45 256.483 139.001 256.483 c
138.553 256.483 138.189 256.651 138.189 256.858 c
b
136.626 255.546 m
136.626 255.753 136.99 255.921 137.439 255.921 c
137.888 255.921 138.251 255.753 138.251 255.546 c
138.251 255.338 137.888 255.171 137.439 255.171 c
136.99 255.171 136.626 255.338 136.626 255.546 c
b
138.751 253.858 m
138.751 254.065 139.115 254.233 139.564 254.233 c
140.013 254.233 140.376 254.065 140.376 253.858 c
140.376 253.651 140.013 253.483 139.564 253.483 c
139.115 253.483 138.751 253.651 138.751 253.858 c
b
139.251 252.858 m
139.251 253.065 139.615 253.233 140.064 253.233 c
140.513 253.233 140.876 253.065 140.876 252.858 c
140.876 252.651 140.513 252.483 140.064 252.483 c
139.615 252.483 139.251 252.651 139.251 252.858 c
b
141.376 254.608 m
141.376 254.815 141.74 254.983 142.189 254.983 c
142.638 254.983 143.001 254.815 143.001 254.608 c
143.001 254.401 142.638 254.233 142.189 254.233 c
141.74 254.233 141.376 254.401 141.376 254.608 c
b
144.626 256.233 m
144.626 256.44 144.99 256.608 145.439 256.608 c
145.888 256.608 146.251 256.44 146.251 256.233 c
146.251 256.026 145.888 255.858 145.439 255.858 c
144.99 255.858 144.626 256.026 144.626 256.233 c
b
144.939 255.045 m
144.939 255.253 145.303 255.42 145.751 255.42 c
146.2 255.42 146.564 255.253 146.564 255.045 c
146.564 254.839 146.2 254.67 145.751 254.67 c
145.303 254.67 144.939 254.839 144.939 255.045 c
b
147.126 257.108 m
147.126 257.315 147.49 257.483 147.939 257.483 c
148.388 257.483 148.751 257.315 148.751 257.108 c
148.751 256.901 148.388 256.733 147.939 256.733 c
147.49 256.733 147.126 256.901 147.126 257.108 c
b
149.376 256.296 m
149.376 256.503 149.74 256.671 150.189 256.671 c
150.638 256.671 151.001 256.503 151.001 256.296 c
151.001 256.088 150.638 255.921 150.189 255.921 c
149.74 255.921 149.376 256.088 149.376 256.296 c
b
152.189 255.42 m
152.189 255.628 152.552 255.795 153.001 255.795 c
153.45 255.795 153.814 255.628 153.814 255.42 c
153.814 255.214 153.45 255.045 153.001 255.045 c
152.552 255.045 152.189 255.214 152.189 255.42 c
b
153.439 254.171 m
153.439 254.378 153.803 254.546 154.251 254.546 c
154.7 254.546 155.064 254.378 155.064 254.171 c
155.064 253.964 154.7 253.796 154.251 253.796 c
153.803 253.796 153.439 253.964 153.439 254.171 c
b
154.689 252.608 m
154.689 252.815 155.052 252.983 155.501 252.983 c
155.95 252.983 156.314 252.815 156.314 252.608 c
156.314 252.401 155.95 252.233 155.501 252.233 c
155.052 252.233 154.689 252.401 154.689 252.608 c
b
151.064 253.233 m
151.064 253.44 151.427 253.608 151.876 253.608 c
152.325 253.608 152.689 253.44 152.689 253.233 c
152.689 253.026 152.325 252.858 151.876 252.858 c
151.427 252.858 151.064 253.026 151.064 253.233 c
b
150.876 251.733 m
150.876 251.94 151.24 252.108 151.689 252.108 c
152.138 252.108 152.501 251.94 152.501 251.733 c
152.501 251.526 152.138 251.358 151.689 251.358 c
151.24 251.358 150.876 251.526 150.876 251.733 c
b
148.626 251.233 m
148.626 251.44 148.99 251.608 149.439 251.608 c
149.888 251.608 150.251 251.44 150.251 251.233 c
150.251 251.026 149.888 250.858 149.439 250.858 c
148.99 250.858 148.626 251.026 148.626 251.233 c
b
148.251 252.358 m
148.251 252.565 148.615 252.733 149.064 252.733 c
149.513 252.733 149.876 252.565 149.876 252.358 c
149.876 252.151 149.513 251.983 149.064 251.983 c
148.615 251.983 148.251 252.151 148.251 252.358 c
b
146.001 253.983 m
146.001 254.19 146.365 254.358 146.814 254.358 c
147.263 254.358 147.626 254.19 147.626 253.983 c
147.626 253.776 147.263 253.608 146.814 253.608 c
146.365 253.608 146.001 253.776 146.001 253.983 c
b
147.876 255.358 m
147.876 255.565 148.24 255.733 148.689 255.733 c
149.138 255.733 149.501 255.565 149.501 255.358 c
149.501 255.151 149.138 254.983 148.689 254.983 c
148.24 254.983 147.876 255.151 147.876 255.358 c
b
152.876 250.608 m
152.876 250.815 153.24 250.983 153.689 250.983 c
154.138 250.983 154.501 250.815 154.501 250.608 c
154.501 250.401 154.138 250.233 153.689 250.233 c
153.24 250.233 152.876 250.401 152.876 250.608 c
b
152.564 249.358 m
152.564 249.565 152.927 249.733 153.376 249.733 c
153.825 249.733 154.189 249.565 154.189 249.358 c
154.189 249.151 153.825 248.983 153.376 248.983 c
152.927 248.983 152.564 249.151 152.564 249.358 c
b
173.718 266.812 m
173.718 267.019 174.082 267.187 174.53 267.187 c
174.979 267.187 175.343 267.019 175.343 266.812 c
175.343 266.605 174.979 266.437 174.53 266.437 c
174.082 266.437 173.718 266.605 173.718 266.812 c
b
172.03 265.75 m
172.03 265.957 172.394 266.125 172.843 266.125 c
173.291 266.125 173.655 265.957 173.655 265.75 c
173.655 265.543 173.291 265.375 172.843 265.375 c
172.394 265.375 172.03 265.543 172.03 265.75 c
b
172.468 262.875 m
172.468 263.082 172.832 263.25 173.28 263.25 c
173.729 263.25 174.093 263.082 174.093 262.875 c
174.093 262.668 173.729 262.5 173.28 262.5 c
172.832 262.5 172.468 262.668 172.468 262.875 c
b
174.968 263.625 m
174.968 263.832 175.331 264 175.78 264 c
176.229 264 176.593 263.832 176.593 263.625 c
176.593 263.418 176.229 263.25 175.78 263.25 c
175.331 263.25 174.968 263.418 174.968 263.625 c
b
177.405 262.875 m
177.405 263.082 177.769 263.25 178.218 263.25 c
178.667 263.25 179.03 263.082 179.03 262.875 c
179.03 262.668 178.667 262.5 178.218 262.5 c
177.769 262.5 177.405 262.668 177.405 262.875 c
b
175.718 261.75 m
175.718 261.957 176.081 262.125 176.53 262.125 c
176.979 262.125 177.343 261.957 177.343 261.75 c
177.343 261.543 176.979 261.375 176.53 261.375 c
176.081 261.375 175.718 261.543 175.718 261.75 c
b
173.218 261.562 m
173.218 261.769 173.582 261.937 174.03 261.937 c
174.479 261.937 174.843 261.769 174.843 261.562 c
174.843 261.355 174.479 261.187 174.03 261.187 c
173.582 261.187 173.218 261.355 173.218 261.562 c
b
174.093 260.5 m
174.093 260.707 174.457 260.875 174.905 260.875 c
175.354 260.875 175.718 260.707 175.718 260.5 c
175.718 260.293 175.354 260.125 174.905 260.125 c
174.457 260.125 174.093 260.293 174.093 260.5 c
b
170.093 259.5 m
170.093 259.707 170.457 259.875 170.905 259.875 c
171.354 259.875 171.718 259.707 171.718 259.5 c
171.718 259.293 171.354 259.125 170.905 259.125 c
170.457 259.125 170.093 259.293 170.093 259.5 c
b
168.53 258.187 m
168.53 258.394 168.894 258.562 169.343 258.562 c
169.792 258.562 170.155 258.394 170.155 258.187 c
170.155 257.98 169.792 257.812 169.343 257.812 c
168.894 257.812 168.53 257.98 168.53 258.187 c
b
170.655 256.5 m
170.655 256.707 171.019 256.875 171.468 256.875 c
171.917 256.875 172.28 256.707 172.28 256.5 c
172.28 256.293 171.917 256.125 171.468 256.125 c
171.019 256.125 170.655 256.293 170.655 256.5 c
b
176.53 258.875 m
176.53 259.082 176.894 259.25 177.343 259.25 c
177.791 259.25 178.155 259.082 178.155 258.875 c
178.155 258.667 177.791 258.5 177.343 258.5 c
176.894 258.5 176.53 258.667 176.53 258.875 c
b
176.843 257.687 m
176.843 257.894 177.206 258.062 177.655 258.062 c
178.104 258.062 178.468 257.894 178.468 257.687 c
178.468 257.48 178.104 257.312 177.655 257.312 c
177.206 257.312 176.843 257.48 176.843 257.687 c
b
179.03 259.75 m
179.03 259.957 179.394 260.125 179.843 260.125 c
180.291 260.125 180.655 259.957 180.655 259.75 c
180.655 259.543 180.291 259.375 179.843 259.375 c
179.394 259.375 179.03 259.543 179.03 259.75 c
b
181.28 258.937 m
181.28 259.144 181.644 259.312 182.093 259.312 c
182.541 259.312 182.905 259.144 182.905 258.937 c
182.905 258.73 182.541 258.562 182.093 258.562 c
181.644 258.562 181.28 258.73 181.28 258.937 c
b
184.093 258.062 m
184.093 258.269 184.457 258.437 184.905 258.437 c
185.354 258.437 185.718 258.269 185.718 258.062 c
185.718 257.855 185.354 257.687 184.905 257.687 c
184.457 257.687 184.093 257.855 184.093 258.062 c
b
185.343 256.812 m
185.343 257.019 185.706 257.187 186.155 257.187 c
186.604 257.187 186.968 257.019 186.968 256.812 c
186.968 256.605 186.604 256.437 186.155 256.437 c
185.706 256.437 185.343 256.605 185.343 256.812 c
b
186.593 255.25 m
186.593 255.457 186.956 255.625 187.405 255.625 c
187.854 255.625 188.218 255.457 188.218 255.25 c
188.218 255.043 187.854 254.875 187.405 254.875 c
186.956 254.875 186.593 255.043 186.593 255.25 c
b
182.968 255.875 m
182.968 256.082 183.332 256.25 183.78 256.25 c
184.229 256.25 184.593 256.082 184.593 255.875 c
184.593 255.667 184.229 255.5 183.78 255.5 c
183.332 255.5 182.968 255.667 182.968 255.875 c
b
182.78 254.375 m
182.78 254.582 183.144 254.75 183.593 254.75 c
184.041 254.75 184.405 254.582 184.405 254.375 c
184.405 254.167 184.041 254 183.593 254 c
183.144 254 182.78 254.167 182.78 254.375 c
b
180.53 253.875 m
180.53 254.082 180.894 254.25 181.343 254.25 c
181.791 254.25 182.155 254.082 182.155 253.875 c
182.155 253.668 181.791 253.5 181.343 253.5 c
180.894 253.5 180.53 253.668 180.53 253.875 c
b
180.155 255 m
180.155 255.207 180.519 255.375 180.968 255.375 c
181.416 255.375 181.78 255.207 181.78 255 c
181.78 254.793 181.416 254.625 180.968 254.625 c
180.519 254.625 180.155 254.793 180.155 255 c
b
177.905 256.625 m
177.905 256.832 178.269 257 178.718 257 c
179.166 257 179.53 256.832 179.53 256.625 c
179.53 256.417 179.166 256.25 178.718 256.25 c
178.269 256.25 177.905 256.417 177.905 256.625 c
b
179.78 258 m
179.78 258.207 180.144 258.375 180.593 258.375 c
181.041 258.375 181.405 258.207 181.405 258 c
181.405 257.793 181.041 257.625 180.593 257.625 c
180.144 257.625 179.78 257.793 179.78 258 c
b
184.78 253.25 m
184.78 253.457 185.144 253.625 185.593 253.625 c
186.041 253.625 186.405 253.457 186.405 253.25 c
186.405 253.043 186.041 252.875 185.593 252.875 c
185.144 252.875 184.78 253.043 184.78 253.25 c
b
184.468 252 m
184.468 252.207 184.832 252.375 185.28 252.375 c
185.729 252.375 186.093 252.207 186.093 252 c
186.093 251.793 185.729 251.625 185.28 251.625 c
184.832 251.625 184.468 251.793 184.468 252 c
b
1 w 
227.018 236.873 m
92.643 236.873 l
S
0.5 w 
98.518 247.806 m
96.643 249.931 94.518 247.181 v
92.393 244.431 92.393 243.181 92.518 241.306 c
92.643 239.431 93.143 237.056 y
104.768 246.931 m
102.643 249.931 99.893 248.556 v
97.143 247.181 98.143 245.056 97.893 243.181 c
97.643 241.306 98.643 236.931 y
111.893 246.931 m
111.643 248.556 108.518 248.806 v
105.393 249.056 104.768 247.806 104.518 245.806 c
104.268 243.806 105.018 237.181 y
119.268 246.806 m
118.393 248.431 116.393 248.681 v
114.393 248.931 112.143 248.306 111.893 246.056 c
111.643 243.806 111.893 241.306 y
112.768 237.806 112.393 237.181 v
126.143 247.431 m
125.018 248.806 123.018 248.806 v
121.018 248.806 119.643 247.931 119.268 246.056 c
118.893 244.181 119.643 240.681 y
119.893 237.306 l
133.393 247.181 m
133.018 249.181 130.143 248.931 v
127.268 248.681 126.018 247.806 125.893 245.806 c
125.768 243.806 126.268 237.056 y
141.018 246.931 m
140.393 248.681 138.268 248.806 v
136.143 248.931 133.643 248.556 133.518 246.306 c
133.393 244.056 133.893 237.181 y
147.393 247.431 m
146.393 249.181 144.268 248.931 v
142.143 248.681 140.893 247.931 140.893 245.931 c
140.893 243.931 141.643 237.056 y
154.768 247.056 m
153.143 248.931 150.768 248.931 v
148.393 248.931 147.268 247.931 147.268 246.181 c
147.268 244.431 147.518 236.931 y
161.893 246.931 m
161.518 248.806 159.893 248.931 v
158.268 249.056 157.018 249.056 y
155.143 248.181 154.893 245.931 v
154.643 243.681 155.268 237.056 y
169.018 246.931 m
166.893 248.931 165.768 248.806 v
164.643 248.681 162.393 248.431 162.143 246.056 c
161.893 243.681 162.768 237.306 y
176.393 247.056 m
175.768 248.931 173.393 248.681 v
171.018 248.431 168.893 248.806 169.018 245.806 c
169.143 242.806 169.143 236.806 y
183.768 246.431 m
183.518 248.806 181.518 248.681 v
179.518 248.556 176.393 249.056 176.393 245.931 c
176.393 242.806 176.518 241.431 y
176.768 237.431 l
190.643 246.681 m
189.768 248.306 187.643 248.306 v
185.518 248.306 183.893 247.431 183.768 246.056 c
183.643 244.681 184.018 241.181 y
184.143 237.306 l
197.768 246.681 m
197.393 248.056 195.768 248.306 v
194.143 248.556 192.768 248.431 y
190.518 247.556 190.393 245.931 v
190.268 244.306 190.518 237.306 y
205.518 246.431 m
204.393 248.181 203.018 248.431 v
201.643 248.681 197.768 248.181 197.893 245.931 c
198.018 243.681 198.143 237.931 198.393 237.431 c
212.018 246.306 m
210.393 248.931 209.018 248.431 v
207.643 247.931 205.018 247.056 205.393 244.431 c
205.768 241.806 205.768 237.056 y
219.268 246.431 m
217.893 248.306 216.268 248.306 v
214.643 248.306 212.018 247.681 211.893 244.806 c
211.768 241.931 212.143 237.181 y
227.018 237.431 m
227.268 240.556 226.893 241.931 v
226.518 243.306 226.767 246.556 226.268 247.056 c
225.768 247.556 225.018 247.806 223.393 247.931 c
221.768 248.056 219.143 247.181 219.268 245.556 c
219.393 243.931 219.143 240.681 y
220.268 237.931 219.643 237.181 v
S
0 0 0 0 k
0.25 w 
63.753 215.63 m
63.753 220.083 67.95 223.693 73.128 223.693 c
78.305 223.693 82.503 220.083 82.503 215.63 c
82.503 211.177 78.305 207.568 73.128 207.568 c
67.95 207.568 63.753 211.177 63.753 215.63 c
b
0 0 0 1 k
70.128 215.255 m
70.128 217.982 72.338 220.193 75.065 220.193 c
77.792 220.193 80.003 217.982 80.003 215.255 c
80.003 212.528 77.792 210.318 75.065 210.318 c
72.338 210.318 70.128 212.528 70.128 215.255 c
b
BT
10 0 0 10 118.127 211.818 Tm
/GS4 gs
(IL-17)Tj
ET
2 w 
/GS3 gs
146.002 216.318 m
175.877 237.193 l
S
175.331 236.81 m
173.037 240.087 l
183.523 242.546 l
177.625 233.534 l
175.331 236.81 l
f*
145.627 214.318 m
168.627 195.318 l
S
168.116 195.746 m
170.688 198.81 l
175.777 189.319 l
165.546 192.682 l
168.116 195.746 l
f*
[4 4 ]0 d
210.002 177.318 m
210.002 250.942 l
S
210.002 250.276 m
206.002 250.276 l
210.002 260.276 l
214.002 250.276 l
210.002 250.276 l
f*
0 0 0 0.3 k
0.5 w []0 d
230.252 215.693 m
230.252 219.283 234.421 222.193 239.564 222.193 c
244.707 222.193 248.877 219.283 248.877 215.693 c
248.877 212.103 244.707 209.193 239.564 209.193 c
234.421 209.193 230.252 212.103 230.252 215.693 c
b
260.627 210.534 m
260.627 214.124 264.796 217.034 269.939 217.034 c
275.082 217.034 279.252 214.124 279.252 210.534 c
279.252 206.944 275.082 204.034 269.939 204.034 c
264.796 204.034 260.627 206.944 260.627 210.534 c
b
249.002 217.068 m
257.252 217.818 262.627 214.693 v
248.877 214.068 m
253.002 215.068 261.002 212.443 v
270.502 217.193 m
276.627 228.318 280.377 228.943 v
273.752 216.693 m
279.002 226.443 283.127 226.943 v
S
BT
10 0 0 10 247.877 225.568 Tm
0 0 0 1 k
/GS4 gs
(NANC)Tj
-2.6375 -2.4 TD
(TK)Tj
-0.6375 1.0625 TD
(TK)Tj
0.7875 1.1625 TD
(TK)Tj
-4.9125 0.2125 TD
(IL-8)Tj
-1.1125 -0.7875 TD
(IL-8)Tj
1.5125 -0.4875 TD
(IL-8)Tj
-1.575 -0.45 TD
(IL-8)Tj
ET
/GS3 gs
189.377 233.13 m
189.377 240.345 191.336 246.193 193.752 246.193 c
196.168 246.193 198.127 240.345 198.127 233.13 c
198.127 225.916 196.168 220.068 193.752 220.068 c
191.336 220.068 189.377 225.916 189.377 233.13 c
s
191.127 236.443 m
191.127 238.928 191.575 240.943 192.127 240.943 c
192.679 240.943 193.127 238.928 193.127 236.443 c
193.127 233.957 192.679 231.943 192.127 231.943 c
191.575 231.943 191.127 233.957 191.127 236.443 c
b
195.127 232.88 m
195.127 235.124 195.631 236.943 196.252 236.943 c
196.873 236.943 197.377 235.124 197.377 232.88 c
197.377 230.636 196.873 228.818 196.252 228.818 c
195.631 228.818 195.127 230.636 195.127 232.88 c
b
192.127 230.443 m
192.127 232.307 192.519 233.818 193.002 233.818 c
193.485 233.818 193.877 232.307 193.877 230.443 c
193.877 228.579 193.485 227.068 193.002 227.068 c
192.519 227.068 192.127 228.579 192.127 230.443 c
b
193.252 228.193 m
193.252 230.816 193.84 232.943 194.565 232.943 c
195.289 232.943 195.877 230.816 195.877 228.193 c
195.877 225.569 195.289 223.443 194.565 223.443 c
193.84 223.443 193.252 225.569 193.252 228.193 c
b
194.377 240.193 m
194.377 240.4 194.517 240.568 194.69 240.568 c
194.862 240.568 195.002 240.4 195.002 240.193 c
195.002 239.985 194.862 239.818 194.69 239.818 c
194.517 239.818 194.377 239.985 194.377 240.193 c
b
194.127 238.505 m
194.127 238.678 194.211 238.818 194.315 238.818 c
194.418 238.818 194.502 238.678 194.502 238.505 c
194.502 238.332 194.418 238.192 194.315 238.192 c
194.211 238.192 194.127 238.332 194.127 238.505 c
b
191.127 230.943 m
191.127 231.15 191.211 231.318 191.315 231.318 c
191.418 231.318 191.502 231.15 191.502 230.943 c
191.502 230.736 191.418 230.568 191.315 230.568 c
191.211 230.568 191.127 230.736 191.127 230.943 c
b
191.377 229.443 m
191.377 229.581 191.433 229.693 191.502 229.693 c
191.571 229.693 191.627 229.581 191.627 229.443 c
191.627 229.305 191.571 229.193 191.502 229.193 c
191.433 229.193 191.377 229.305 191.377 229.443 c
b
191.002 226.505 m
191.002 226.747 191.142 226.943 191.315 226.943 c
191.487 226.943 191.627 226.747 191.627 226.505 c
191.627 226.264 191.487 226.068 191.315 226.068 c
191.142 226.068 191.002 226.264 191.002 226.505 c
b
191.752 225.443 m
191.752 225.581 191.836 225.693 191.94 225.693 c
192.043 225.693 192.127 225.581 192.127 225.443 c
192.127 225.304 192.043 225.193 191.94 225.193 c
191.836 225.193 191.752 225.304 191.752 225.443 c
b
191.502 224.005 m
191.502 224.178 191.558 224.318 191.627 224.318 c
191.696 224.318 191.752 224.178 191.752 224.005 c
191.752 223.833 191.696 223.693 191.627 223.693 c
191.558 223.693 191.502 223.833 191.502 224.005 c
b
187.255 202.482 m
188.761 209.569 192.439 214.791 195.47 214.147 c
198.5 213.503 199.736 207.236 198.229 200.149 c
196.723 193.062 193.045 187.84 190.015 188.484 c
186.984 189.128 185.749 195.395 187.255 202.482 c
s
187.627 195.755 m
187.627 195.928 187.739 196.068 187.877 196.068 c
188.015 196.068 188.127 195.928 188.127 195.755 c
188.127 195.583 188.015 195.443 187.877 195.443 c
187.739 195.443 187.627 195.583 187.627 195.755 c
b
188.502 194.193 m
188.502 194.434 188.572 194.63 188.658 194.63 c
188.745 194.63 188.815 194.434 188.815 194.193 c
188.815 193.951 188.745 193.755 188.658 193.755 c
188.572 193.755 188.502 193.951 188.502 194.193 c
b
187.815 192.911 m
187.815 193.067 187.927 193.193 188.065 193.193 c
188.203 193.193 188.315 193.067 188.315 192.911 c
188.315 192.756 188.203 192.63 188.065 192.63 c
187.927 192.63 187.815 192.756 187.815 192.911 c
b
193.752 204.662 m
193.752 204.886 193.85 205.068 193.971 205.068 c
194.092 205.068 194.19 204.886 194.19 204.662 c
194.19 204.437 194.092 204.255 193.971 204.255 c
193.85 204.255 193.752 204.437 193.752 204.662 c
b
194.565 206.005 m
194.565 206.247 194.649 206.443 194.752 206.443 c
194.856 206.443 194.94 206.247 194.94 206.005 c
194.94 205.764 194.856 205.568 194.752 205.568 c
194.649 205.568 194.565 205.764 194.565 206.005 c
b
195.252 207.349 m
195.252 207.539 195.266 207.693 195.283 207.693 c
195.301 207.693 195.315 207.539 195.315 207.349 c
195.315 207.159 195.301 207.005 195.283 207.005 c
195.266 207.005 195.252 207.159 195.252 207.349 c
b
195.065 203.224 m
195.065 203.414 195.079 203.568 195.096 203.568 c
195.113 203.568 195.127 203.414 195.127 203.224 c
195.127 203.034 195.113 202.88 195.096 202.88 c
195.079 202.88 195.065 203.034 195.065 203.224 c
b
193.752 201.849 m
193.752 202.177 193.85 202.443 193.971 202.443 c
194.092 202.443 194.19 202.177 194.19 201.849 c
194.19 201.521 194.092 201.255 193.971 201.255 c
193.85 201.255 193.752 201.521 193.752 201.849 c
b
188.94 199.599 m
188.94 199.858 189.038 200.068 189.158 200.068 c
189.279 200.068 189.377 199.858 189.377 199.599 c
189.377 199.34 189.279 199.13 189.158 199.13 c
189.038 199.13 188.94 199.34 188.94 199.599 c
b
189.44 198.099 m
189.44 198.22 189.454 198.318 189.471 198.318 c
189.488 198.318 189.502 198.22 189.502 198.099 c
189.502 197.978 189.488 197.88 189.471 197.88 c
189.454 197.88 189.44 197.978 189.44 198.099 c
b
189.127 196.224 m
189.127 196.345 189.197 196.443 189.283 196.443 c
189.37 196.443 189.44 196.345 189.44 196.224 c
189.44 196.103 189.37 196.005 189.283 196.005 c
189.197 196.005 189.127 196.103 189.127 196.224 c
b
189.397 205.534 m
189.754 208.07 190.831 210.015 191.804 209.878 c
192.776 209.741 193.276 207.575 192.919 205.039 c
192.563 202.503 191.486 200.558 190.513 200.695 c
189.541 200.832 189.041 202.998 189.397 205.534 c
b
194.048 200.352 m
194.799 202.665 196.206 204.28 197.191 203.961 c
198.175 203.64 198.364 201.506 197.613 199.193 c
196.861 196.88 195.454 195.265 194.47 195.585 c
193.485 195.905 193.296 198.039 194.048 200.352 c
b
190.239 199.531 m
190.907 201.271 191.945 202.491 192.557 202.256 c
193.17 202.021 193.124 200.42 192.456 198.679 c
191.788 196.939 190.751 195.719 190.138 195.954 c
189.526 196.189 189.571 197.79 190.239 199.531 c
b
190.641 196.83 m
191.499 199.186 193.172 200.74 194.379 200.301 c
195.586 199.861 195.869 197.595 195.012 195.239 c
194.154 192.882 192.48 191.329 191.273 191.768 c
190.067 192.207 189.783 194.474 190.641 196.83 c
b
1 w 
225.752 188.443 m
93.003 188.443 l
S
0.5 w 
177.127 180.255 m
177.127 183.535 183.591 186.193 191.565 186.193 c
199.538 186.193 206.002 183.535 206.002 180.255 c
206.002 176.976 199.538 174.318 191.565 174.318 c
183.591 174.318 177.127 176.976 177.127 180.255 c
h
167.127 166.068 m
167.127 170.97 172.919 174.943 180.065 174.943 c
187.21 174.943 193.002 170.97 193.002 166.068 c
193.002 161.166 187.21 157.193 180.065 157.193 c
172.919 157.193 167.127 161.166 167.127 166.068 c
h
142.252 157.443 m
142.252 163.38 148.101 168.193 155.315 168.193 c
162.529 168.193 168.377 163.38 168.377 157.443 c
168.377 151.506 162.529 146.693 155.315 146.693 c
148.101 146.693 142.252 151.506 142.252 157.443 c
h
113.627 158.13 m
113.627 164.378 119.504 169.443 126.752 169.443 c
134.001 169.443 139.877 164.378 139.877 158.13 c
139.877 151.883 134.001 146.818 126.752 146.818 c
119.504 146.818 113.627 151.883 113.627 158.13 c
h
83.503 159.568 m
83.503 165.85 89.295 170.943 96.44 170.943 c
103.585 170.943 109.378 165.85 109.378 159.568 c
109.378 153.286 103.585 148.193 96.44 148.193 c
89.295 148.193 83.503 153.286 83.503 159.568 c
s
88.128 162.849 m
88.128 165.076 89.653 166.88 91.534 166.88 c
93.415 166.88 94.94 165.076 94.94 162.849 c
94.94 160.623 93.415 158.818 91.534 158.818 c
89.653 158.818 88.128 160.623 88.128 162.849 c
b
89.628 157.724 m
89.628 157.879 89.893 158.006 90.221 158.006 c
90.549 158.006 90.815 157.879 90.815 157.724 c
90.815 157.569 90.549 157.443 90.221 157.443 c
89.893 157.443 89.628 157.569 89.628 157.724 c
b
88.44 153.912 m
88.44 154.102 88.72 154.256 89.065 154.256 c
89.41 154.256 89.69 154.102 89.69 153.912 c
89.69 153.722 89.41 153.568 89.065 153.568 c
88.72 153.568 88.44 153.722 88.44 153.912 c
b
90.565 152.849 m
90.565 153.039 90.775 153.193 91.034 153.193 c
91.293 153.193 91.503 153.039 91.503 152.849 c
91.503 152.659 91.293 152.505 91.034 152.505 c
90.775 152.505 90.565 152.659 90.565 152.849 c
b
90.128 151.724 m
90.128 151.845 90.253 151.943 90.409 151.943 c
90.564 151.943 90.69 151.845 90.69 151.724 c
90.69 151.603 90.564 151.506 90.409 151.506 c
90.253 151.506 90.128 151.603 90.128 151.724 c
b
97.503 162.755 m
97.503 162.928 97.713 163.068 97.971 163.068 c
98.23 163.068 98.44 162.928 98.44 162.755 c
98.44 162.583 98.23 162.443 97.971 162.443 c
97.713 162.443 97.503 162.583 97.503 162.755 c
b
98.628 160.724 m
98.628 160.914 98.809 161.068 99.034 161.068 c
99.258 161.068 99.44 160.914 99.44 160.724 c
99.44 160.534 99.258 160.38 99.034 160.38 c
98.809 160.38 98.628 160.534 98.628 160.724 c
b
100.128 161.787 m
100.128 161.942 100.309 162.068 100.534 162.068 c
100.758 162.068 100.94 161.942 100.94 161.787 c
100.94 161.632 100.758 161.505 100.534 161.505 c
100.309 161.505 100.128 161.632 100.128 161.787 c
b
98.44 164.474 m
98.44 164.664 98.594 164.818 98.784 164.818 c
98.974 164.818 99.128 164.664 99.128 164.474 c
99.128 164.284 98.974 164.13 98.784 164.13 c
98.594 164.13 98.44 164.284 98.44 164.474 c
b
99.378 165.724 m
99.378 165.914 99.574 166.068 99.815 166.068 c
100.057 166.068 100.253 165.914 100.253 165.724 c
100.253 165.534 100.057 165.38 99.815 165.38 c
99.574 165.38 99.378 165.534 99.378 165.724 c
b
102.003 159.506 m
102.003 161.646 103.206 163.38 104.69 163.38 c
106.174 163.38 107.378 161.646 107.378 159.506 c
107.378 157.365 106.174 155.631 104.69 155.631 c
103.206 155.631 102.003 157.365 102.003 159.506 c
b
91.94 157.755 m
91.94 159.413 92.878 160.755 94.034 160.755 c
95.19 160.755 96.128 159.413 96.128 157.755 c
96.128 156.098 95.19 154.755 94.034 154.755 c
92.878 154.755 91.94 156.098 91.94 157.755 c
b
94.44 154.943 m
94.44 156.876 95.797 158.443 97.471 158.443 c
99.146 158.443 100.503 156.876 100.503 154.943 c
100.503 153.01 99.146 151.443 97.471 151.443 c
95.797 151.443 94.44 153.01 94.44 154.943 c
b
96.253 155.693 m
96.253 158.213 97.848 160.256 99.815 160.256 c
101.783 160.256 103.378 158.213 103.378 155.693 c
103.378 153.173 101.783 151.131 99.815 151.131 c
97.848 151.131 96.253 153.173 96.253 155.693 c
b
118.17 161.329 m
118.17 163.556 119.695 165.361 121.576 165.361 c
123.458 165.361 124.983 163.556 124.983 161.329 c
124.983 159.103 123.458 157.298 121.576 157.298 c
119.695 157.298 118.17 159.103 118.17 161.329 c
b
119.67 156.205 m
119.67 156.36 119.936 156.486 120.264 156.486 c
120.592 156.486 120.858 156.36 120.858 156.205 c
120.858 156.049 120.592 155.923 120.264 155.923 c
119.936 155.923 119.67 156.049 119.67 156.205 c
b
118.483 152.392 m
118.483 152.582 118.763 152.736 119.108 152.736 c
119.453 152.736 119.733 152.582 119.733 152.392 c
119.733 152.202 119.453 152.048 119.108 152.048 c
118.763 152.048 118.483 152.202 118.483 152.392 c
b
120.608 151.33 m
120.608 151.519 120.817 151.673 121.076 151.673 c
121.335 151.673 121.545 151.519 121.545 151.33 c
121.545 151.14 121.335 150.986 121.076 150.986 c
120.817 150.986 120.608 151.14 120.608 151.33 c
b
120.17 150.205 m
120.17 150.325 120.296 150.423 120.451 150.423 c
120.607 150.423 120.733 150.325 120.733 150.205 c
120.733 150.084 120.607 149.986 120.451 149.986 c
120.296 149.986 120.17 150.084 120.17 150.205 c
b
127.545 161.236 m
127.545 161.408 127.755 161.548 128.014 161.548 c
128.273 161.548 128.483 161.408 128.483 161.236 c
128.483 161.063 128.273 160.923 128.014 160.923 c
127.755 160.923 127.545 161.063 127.545 161.236 c
b
128.67 159.205 m
128.67 159.394 128.852 159.548 129.076 159.548 c
129.301 159.548 129.483 159.394 129.483 159.205 c
129.483 159.015 129.301 158.861 129.076 158.861 c
128.852 158.861 128.67 159.015 128.67 159.205 c
b
130.17 160.267 m
130.17 160.422 130.352 160.548 130.576 160.548 c
130.801 160.548 130.983 160.422 130.983 160.267 c
130.983 160.112 130.801 159.986 130.576 159.986 c
130.352 159.986 130.17 160.112 130.17 160.267 c
b
128.483 162.954 m
128.483 163.144 128.636 163.298 128.826 163.298 c
129.016 163.298 129.17 163.144 129.17 162.954 c
129.17 162.765 129.016 162.611 128.826 162.611 c
128.636 162.611 128.483 162.765 128.483 162.954 c
b
129.42 164.205 m
129.42 164.394 129.616 164.548 129.858 164.548 c
130.099 164.548 130.295 164.394 130.295 164.205 c
130.295 164.015 130.099 163.861 129.858 163.861 c
129.616 163.861 129.42 164.015 129.42 164.205 c
b
132.045 157.986 m
132.045 160.126 133.248 161.861 134.732 161.861 c
136.217 161.861 137.42 160.126 137.42 157.986 c
137.42 155.846 136.217 154.111 134.732 154.111 c
133.248 154.111 132.045 155.846 132.045 157.986 c
b
121.983 156.236 m
121.983 157.893 122.92 159.236 124.076 159.236 c
125.233 159.236 126.17 157.893 126.17 156.236 c
126.17 154.579 125.233 153.236 124.076 153.236 c
122.92 153.236 121.983 154.579 121.983 156.236 c
b
124.483 153.423 m
124.483 155.356 125.84 156.923 127.514 156.923 c
129.188 156.923 130.545 155.356 130.545 153.423 c
130.545 151.49 129.188 149.923 127.514 149.923 c
125.84 149.923 124.483 151.49 124.483 153.423 c
b
126.295 154.173 m
126.295 156.693 127.89 158.736 129.858 158.736 c
131.825 158.736 133.42 156.693 133.42 154.173 c
133.42 151.654 131.825 149.611 129.858 149.611 c
127.89 149.611 126.295 151.654 126.295 154.173 c
b
90.94 156.474 m
90.94 156.664 91.15 156.818 91.409 156.818 c
91.668 156.818 91.878 156.664 91.878 156.474 c
91.878 156.284 91.668 156.131 91.409 156.131 c
91.15 156.131 90.94 156.284 90.94 156.474 c
b
92.128 154.787 m
92.128 154.908 92.31 155.006 92.534 155.006 c
92.758 155.006 92.94 154.908 92.94 154.787 c
92.94 154.666 92.758 154.568 92.534 154.568 c
92.31 154.568 92.128 154.666 92.128 154.787 c
b
121.065 154.787 m
121.065 154.977 121.303 155.13 121.596 155.13 c
121.89 155.13 122.127 154.977 122.127 154.787 c
122.127 154.597 121.89 154.443 121.596 154.443 c
121.303 154.443 121.065 154.597 121.065 154.787 c
b
122.378 153.193 m
122.378 153.4 122.559 153.568 122.784 153.568 c
123.008 153.568 123.19 153.4 123.19 153.193 c
123.19 152.986 123.008 152.818 122.784 152.818 c
122.559 152.818 122.378 152.986 122.378 153.193 c
b
146.908 160.204 m
146.908 162.431 148.433 164.236 150.314 164.236 c
152.195 164.236 153.72 162.431 153.72 160.204 c
153.72 157.978 152.195 156.173 150.314 156.173 c
148.433 156.173 146.908 157.978 146.908 160.204 c
b
148.691 155.505 m
148.691 155.66 148.957 155.786 149.285 155.786 c
149.613 155.786 149.878 155.66 149.878 155.505 c
149.878 155.349 149.613 155.223 149.285 155.223 c
148.957 155.223 148.691 155.349 148.691 155.505 c
b
147.22 151.834 m
147.22 152.024 147.5 152.178 147.845 152.178 c
148.19 152.178 148.47 152.024 148.47 151.834 c
148.47 151.644 148.19 151.49 147.845 151.49 c
147.5 151.49 147.22 151.644 147.22 151.834 c
b
149.345 150.771 m
149.345 150.961 149.555 151.115 149.814 151.115 c
150.073 151.115 150.282 150.961 150.282 150.771 c
150.282 150.581 150.073 150.428 149.814 150.428 c
149.555 150.428 149.345 150.581 149.345 150.771 c
b
148.907 149.646 m
148.907 149.767 149.033 149.865 149.189 149.865 c
149.344 149.865 149.47 149.767 149.47 149.646 c
149.47 149.526 149.344 149.428 149.189 149.428 c
149.033 149.428 148.907 149.526 148.907 149.646 c
b
156.282 160.111 m
156.282 160.283 156.492 160.423 156.751 160.423 c
157.01 160.423 157.22 160.283 157.22 160.111 c
157.22 159.938 157.01 159.798 156.751 159.798 c
156.492 159.798 156.282 159.938 156.282 160.111 c
b
157.407 158.08 m
157.407 158.269 157.589 158.423 157.814 158.423 c
158.038 158.423 158.22 158.269 158.22 158.08 c
158.22 157.89 158.038 157.736 157.814 157.736 c
157.589 157.736 157.407 157.89 157.407 158.08 c
b
158.907 159.142 m
158.907 159.297 159.089 159.423 159.314 159.423 c
159.538 159.423 159.72 159.297 159.72 159.142 c
159.72 158.987 159.538 158.861 159.314 158.861 c
159.089 158.861 158.907 158.987 158.907 159.142 c
b
157.22 161.829 m
157.22 162.019 157.374 162.173 157.564 162.173 c
157.754 162.173 157.907 162.019 157.907 161.829 c
157.907 161.64 157.754 161.486 157.564 161.486 c
157.374 161.486 157.22 161.64 157.22 161.829 c
b
158.157 163.08 m
158.157 163.269 158.353 163.423 158.595 163.423 c
158.837 163.423 159.032 163.269 159.032 163.08 c
159.032 162.89 158.837 162.736 158.595 162.736 c
158.353 162.736 158.157 162.89 158.157 163.08 c
b
160.782 156.861 m
160.782 159.001 161.986 160.736 163.47 160.736 c
164.954 160.736 166.157 159.001 166.157 156.861 c
166.157 154.721 164.954 152.986 163.47 152.986 c
161.986 152.986 160.782 154.721 160.782 156.861 c
b
151.145 155.111 m
151.145 156.768 152.083 158.111 153.239 158.111 c
154.395 158.111 155.333 156.768 155.333 155.111 c
155.333 153.454 154.395 152.111 153.239 152.111 c
152.083 152.111 151.145 153.454 151.145 155.111 c
b
153.22 152.298 m
153.22 154.231 154.577 155.798 156.251 155.798 c
157.925 155.798 159.282 154.231 159.282 152.298 c
159.282 150.365 157.925 148.798 156.251 148.798 c
154.577 148.798 153.22 150.365 153.22 152.298 c
b
155.033 153.048 m
155.033 155.568 156.628 157.611 158.595 157.611 c
160.562 157.611 162.157 155.568 162.157 153.048 c
162.157 150.529 160.562 148.486 158.595 148.486 c
156.628 148.486 155.033 150.529 155.033 153.048 c
b
149.786 154.428 m
149.786 154.584 149.996 154.71 150.254 154.71 c
150.513 154.71 150.723 154.584 150.723 154.428 c
150.723 154.273 150.513 154.147 150.254 154.147 c
149.996 154.147 149.786 154.273 149.786 154.428 c
b
150.502 152.693 m
150.502 152.935 150.698 153.131 150.94 153.131 c
151.181 153.131 151.377 152.935 151.377 152.693 c
151.377 152.451 151.181 152.256 150.94 152.256 c
150.698 152.256 150.502 152.451 150.502 152.693 c
b
172.002 161.63 m
172.002 161.734 172.212 161.818 172.471 161.818 c
172.73 161.818 172.94 161.734 172.94 161.63 c
172.94 161.527 172.73 161.443 172.471 161.443 c
172.212 161.443 172.002 161.527 172.002 161.63 c
b
173.815 160.849 m
173.815 160.935 174.025 161.006 174.283 161.006 c
174.542 161.006 174.752 160.935 174.752 160.849 c
174.752 160.763 174.542 160.693 174.283 160.693 c
174.025 160.693 173.815 160.763 173.815 160.849 c
b
173.44 160.068 m
173.44 160.172 173.664 160.256 173.94 160.256 c
174.216 160.256 174.44 160.172 174.44 160.068 c
174.44 159.964 174.216 159.881 173.94 159.881 c
173.664 159.881 173.44 159.964 173.44 160.068 c
b
175.252 162.474 m
175.252 162.63 175.504 162.755 175.815 162.755 c
176.125 162.755 176.377 162.63 176.377 162.474 c
176.377 162.319 176.125 162.193 175.815 162.193 c
175.504 162.193 175.252 162.319 175.252 162.474 c
b
174.19 163.537 m
174.19 163.658 174.428 163.755 174.721 163.755 c
175.014 163.755 175.252 163.658 175.252 163.537 c
175.252 163.416 175.014 163.318 174.721 163.318 c
174.428 163.318 174.19 163.416 174.19 163.537 c
b
173.065 164.474 m
173.065 164.629 173.275 164.756 173.533 164.756 c
173.792 164.756 174.002 164.629 174.002 164.474 c
174.002 164.319 173.792 164.193 173.533 164.193 c
173.275 164.193 173.065 164.319 173.065 164.474 c
b
183.69 167.662 m
183.69 167.783 183.913 167.88 184.19 167.88 c
184.466 167.88 184.69 167.783 184.69 167.662 c
184.69 167.541 184.466 167.443 184.19 167.443 c
183.913 167.443 183.69 167.541 183.69 167.662 c
b
181.877 166.912 m
181.877 166.998 182.101 167.068 182.377 167.068 c
182.653 167.068 182.877 166.998 182.877 166.912 c
182.877 166.826 182.653 166.755 182.377 166.755 c
182.101 166.755 181.877 166.826 181.877 166.912 c
b
181.065 168.474 m
181.065 168.595 181.219 168.693 181.408 168.693 c
181.598 168.693 181.752 168.595 181.752 168.474 c
181.752 168.353 181.598 168.255 181.408 168.255 c
181.219 168.255 181.065 168.353 181.065 168.474 c
b
181.815 169.474 m
181.815 169.629 182.025 169.755 182.283 169.755 c
182.542 169.755 182.752 169.629 182.752 169.474 c
182.752 169.319 182.542 169.193 182.283 169.193 c
182.025 169.193 181.815 169.319 181.815 169.474 c
b
182.877 170.443 m
182.877 170.581 183.059 170.693 183.283 170.693 c
183.508 170.693 183.69 170.581 183.69 170.443 c
183.69 170.305 183.508 170.193 183.283 170.193 c
183.059 170.193 182.877 170.305 182.877 170.443 c
b
171.44 168.38 m
171.44 170.003 172.993 171.318 174.908 171.318 c
176.824 171.318 178.377 170.003 178.377 168.38 c
178.377 166.758 176.824 165.443 174.908 165.443 c
172.993 165.443 171.44 166.758 171.44 168.38 c
b
174.815 164.599 m
174.815 165.997 175.948 167.13 177.346 167.13 c
178.744 167.13 179.877 165.997 179.877 164.599 c
179.877 163.201 178.744 162.068 177.346 162.068 c
175.948 162.068 174.815 163.201 174.815 164.599 c
b
180.315 163.068 m
180.315 164.932 181.896 166.443 183.846 166.443 c
185.796 166.443 187.377 164.932 187.377 163.068 c
187.377 161.204 185.796 159.693 183.846 159.693 c
181.896 159.693 180.315 161.204 180.315 163.068 c
b
185.627 165.818 m
185.627 167.337 186.788 168.568 188.221 168.568 c
189.653 168.568 190.815 167.337 190.815 165.818 c
190.815 164.299 189.653 163.068 188.221 163.068 c
186.788 163.068 185.627 164.299 185.627 165.818 c
b
177.252 162.63 m
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