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10.0265 0 0 9.9 99.26 581.53 Tm (and )Tj -0.035 Tc 9.46 0 0 9.9 122.29 581.53 Tm (3\) )Tj 0.0425 Tc 9.9 0 0 9.9 136.7 581.53 Tm (after )Tj 0.0252 Tc 2.675 0 Td (methylcholine )Tj 0.05 Tc 10.5727 0 0 9.9 229.34 581.53 Tm (or )Tj 0.0242 Tc 9.9 0 0 9.9 245.75 581.53 Tm (histamine )Tj 0.0281 Tc -18.771 -1.116 Td (inhalation. )Tj 0.0249 Tc 0.927 -1.115 Td (Acetyl-beta-methylcholine )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0181 Tc 9.9 0 0 9.9 186.5975 559.4431 Tm (\(Sigma )Tj EMC ET BT /T1_0 1 Tf 9.9 0 0 9.9 222.6137 559.4431 Tm (Chemicals, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0091 Tc 9.9 0 0 9.9 274.856 559.4431 Tm (St. )Tj EMC ET BT /T1_0 1 Tf 0.0209 Tc 9.9 0 0 9.9 59.4617 548.8897 Tm (Louis, )Tj 0.188 0.188 0.184 rg 0 Tc 3.153 0 Td (M)Tj 0.341 0.341 0.333 rg 0.05 Tc 9.9089 0 0 9.9 99.74 548.89 Tm (o.\) )Tj 0.278 0.278 0.275 rg 10.0265 0 0 9.9 115.58 548.89 Tm (and )Tj 0.0242 Tc 9.9 0 0 9.9 136.31 548.89 Tm (histamine )Tj 0.0461 Tc 4.561 0 Td (phosphate )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0161 Tc 9.9 0 0 9.9 229.3205 548.89 Tm (\(Sigma\) )Tj EMC ET BT /T1_0 1 Tf 0.0009 Tc 9.9 0 0 9.9 266.8712 548.89 Tm (were )Tj 0.024 Tc -21.002 -1.115 Td (diluted )Tj 0.0149 Tc 3.589 0 Td (in )Tj 0.341 0.341 0.333 rg 0 Tc 1.356 0 Td (a )Tj ET BT /Suspect <>BDC 0.278 0.278 0.275 rg /T1_0 1 Tf 9.9 0 0 9.9 117.9851 537.8515 Tm (0)Tj 0.098 0.098 0.094 rg 0.571 0 Td (.)Tj 0.278 0.278 0.275 rg 0.375 0 Td (1 )Tj EMC ET BT /T1_0 1 Tf 9.9 0 0 9.9 137.2505 537.8515 Tm (M )Tj 0.341 0.341 0.333 rg 0.0371 Tc 1.493 0 Td (sodium )Tj 0.278 0.278 0.275 rg 0.05 Tc 9.9393 0 0 9.9 188.66 537.85 Tm (phosphate )Tj 0.0178 Tc 9.9 0 0 9.9 238.57 537.85 Tm (buffer )Tj 0.05 Tc 10.2684 0 0 9.9 269.16 537.85 Tm (\(pH )Tj 0.341 0.341 0.333 rg -0.0066 Tc 9.9 0 0 9.9 58.93 526.8 Tm (7.3)Tj 0.682 0.682 0.671 rg 0 Tc 1.26 0 Td (-)Tj 0.341 0.341 0.333 rg -0.0023 Tc 0.631 0 Td (7.4\) )Tj 0.0088 Tc 2.046 0 Td (which )Tj 0.278 0.278 0.275 rg 0.0252 Tc 2.958 0 Td (was )Tj 0.0037 Tc 2.086 0 Td (used )Tj 0.0033 Tc 2.366 0 Td (as )Tj 0.341 0.341 0.333 rg 0 Tc 1.309 0 Td (a )Tj 0.0408 Tc 0.921 0 Td (control )Tj 0.278 0.278 0.275 rg 0.03 Tc 3.535 0 Td (solution. )Tj 0.05 Tc 10.4358 0 0 9.9 270.67 526.8 Tm (For )Tj 0.0412 Tc 9.9 0 0 9.9 59.53 515.76 Tm (both )Tj 0.031 Tc 2.317 0 Td (drugs, )Tj 0.0236 Tc 3.11 0 Td (twofold )Tj 0.0198 Tc 3.727 0 Td (increasing )Tj 0.341 0.341 0.333 rg 0.0383 Tc 4.701 0 Td (concentrations )Tj 0.0407 Tc 6.735 0 Td (start\255)Tj 0.278 0.278 0.275 rg 0.0241 Tc -20.648 -1.066 Td (ing )Tj 0.341 0.341 0.333 rg 0.0086 Tc 1.694 0 Td (from )Tj ET BT /Suspect <>BDC 0.278 0.278 0.275 rg /T1_0 1 Tf 0.0057 Tc 9.9 0 0 9.9 99.2587 505.2066 Tm (0.03 )Tj EMC ET BT /T1_0 1 Tf 0.0188 Tc 9.9 0 0 9.9 120.9595 505.2066 Tm (up )Tj 0.0011 Tc 1.453 0 Td (to )Tj 0.341 0.341 0.333 rg -0.035 Tc 9.8266 0 0 9.9 147.25 505.21 Tm (32 )Tj ET BT /Suspect <>BDC 0.278 0.278 0.275 rg /T1_0 1 Tf 0.05 Tc 10.1998 0 0 9.9 160.3 505.21 Tm (mg\267ml )Tj EMC ET BT 0.341 0.341 0.333 rg /T1_0 1 Tf 0 Tc 6.2 0 0 6.2 197.07 509.05 Tm (1 )Tj 0.278 0.278 0.275 rg 0.0009 Tc 9.9 0 0 9.9 203.99 505.21 Tm (were )Tj 0.0492 Tc 2.282 0 Td (prepared )Tj -0.035 Tc 9.6519 0 0 9.9 268.09 505.21 Tm ([10]. )Tj 0.05 Tc 10.4937 0 0 9.9 58.47 494.16 Tm (To )Tj 0.0234 Tc 9.9 0 0 9.9 78.16 494.16 Tm (induce )Tj 0.0337 Tc 3.548 0 Td (bronchoconstriction, )Tj 0.0457 Tc 9.645 0 Td (the )Tj 0.0218 Tc 2.024 0 Td (subjects )Tj -0.007 Tc 4.124 0 Td (first )Tj 0.0218 Tc -21.282 -1.115 Td (inhaled )Tj 0.0251 Tc 3.588 0 Td (increasing )Tj 0.0383 Tc 4.749 0 Td (concentrations )Tj 0.341 0.341 0.333 rg 0.05 Tc 10.5727 0 0 9.9 209.18 483.12 Tm (of )Tj 0.278 0.278 0.275 rg 0.0303 Tc 9.9 0 0 9.9 222.71 483.12 Tm (histamine )Tj 0.05 Tc 10.7518 0 0 9.9 268.21 483.12 Tm (at )Tj 0 Tc 9.9 0 0 9.9 281.11 483.12 Tm (8 )Tj 0.0376 Tc -22.433 -1.067 Td (minute )Tj 0.0206 Tc 3.339 0 Td (intervals)Tj 0.098 0.098 0.094 rg 0 Tc 3.672 0 Td (. )Tj ET BT /Suspect <>BDC 0.278 0.278 0.275 rg /T1_0 1 Tf 0.05 Tc 10.3701 0 0 9.9 134.3 472.56 Tm (On )Tj EMC ET BT /T1_0 1 Tf 9.9363 0 0 9.9 151.1 472.56 Tm (another )Tj 10.0131 0 0 9.9 187.11 472.56 Tm (day )Tj 0.0293 Tc 9.9 0 0 9.9 206.38 472.56 Tm (methylcholine )Tj 0.188 0.188 0.184 rg 0.001 Tc 6.449 0 Td (was )Tj 0.278 0.278 0.275 rg 0.0098 Tc -21.334 -1.114 Td (tested )Tj -0.0336 Tc 2.952 0 Td (in )Tj 0.341 0.341 0.333 rg 0 Tc 1.255 0 Td (s)Tj 0.188 0.188 0.184 rg 0.0307 Tc 0.394 0 Td (imilar )Tj 0.278 0.278 0.275 rg 0.031 Tc 3.004 0 Td (conditions. )Tj 0.0365 Tc 5.239 0 Td (Inhaled )Tj 0.0383 Tc 3.73 0 Td (concentrations )Tj 0.0158 Tc -16.622 -1.115 Td (varied )Tj 0.0126 Tc 2.961 0 Td (between )Tj -0.0081 Tc 3.722 0 Td (0.5 )Tj 0.341 0.341 0.333 rg 0.05 Tc 10.0265 0 0 9.9 140.06 450.49 Tm (and )Tj 0.0066 Tc 9.9 0 0 9.9 158.76 450.49 Tm (32 )Tj 0.278 0.278 0.275 rg 0.0365 Tc 1.319 0 Td (mg )Tj ET BT /Suspect <>BDC 0 0.004 0 rg /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 186.0246 450.49 Tm (\267)Tj 0.278 0.278 0.275 rg -0.0314 Tc 0.359 0 Td (ml)Tj 0.572 0.577 0.565 rg 0 Tc 1.251 0 Td (-)Tj 0.278 0.278 0.275 rg /T1_1 1 Tf 5.2 0 0 5.2 208.16 454.33 Tm (1 )Tj EMC ET BT 0.341 0.341 0.333 rg /T1_0 1 Tf 0.05 Tc 10.0265 0 0 9.9 214.46 450.49 Tm (and )Tj 0.278 0.278 0.275 rg 0.0009 Tc 9.9 0 0 9.9 233.27 450.49 Tm (were )Tj 0.012 Tc 2.28 0 Td (usually )Tj -0.0028 Tc -19.881 -1.116 Td (the )Tj 0.341 0.341 0.333 rg 0.0355 Tc 1.879 0 Td (same )Tj 0.278 0.278 0.275 rg 0.0135 Tc 2.815 0 Td (for )Tj 0.0412 Tc 1.903 0 Td (both )Tj 0.0213 Tc 2.608 0 Td (drugs. )Tj -0.029 Tc 3.304 0 Td (All )Tj 0.341 0.341 0.333 rg 0.0457 Tc 1.939 0 Td (the )Tj 0.0369 Tc 1.927 0 Td (solutions )Tj 0.278 0.278 0.275 rg 0.0171 Tc 4.522 0 Td (were )Tj 0.0218 Tc -20.953 -1.114 Td (inhaled )Tj 0.0086 Tc 3.682 0 Td (from )Tj 0.0457 Tc 2.627 0 Td (the )Tj 0.341 0.341 0.333 rg 0.0355 Tc 1.83 0 Td (same )Tj 0.278 0.278 0.275 rg 0.0208 Tc 2.728 0 Td (nebulizer )Tj 0.0362 Tc 4.449 0 Td (\(De )Tj 0.0062 Tc 2.095 0 Td (Yilbiss )Tj -0.0048 Tc 3.432 0 Td (646\))Tj 0.431 0.435 0.423 rg 0 Tc 1.839 0 Td (, )Tj 0.278 0.278 0.275 rg 0.026 Tc -22.674 -1.115 Td (powered )Tj 0.0075 Tc 3.876 0 Td (with )Tj 0.05 Tc 10.0881 0 0 9.9 117.5 417.37 Tm (air )Tj 10.7518 0 0 9.9 131.41 417.37 Tm (at )Tj 0 Tc 9.9 0 0 9.9 141.98 417.37 Tm (a )Tj -0.035 Tc 9.8958 0 0 9.9 149.65 417.37 Tm (flow )Tj 0.341 0.341 0.333 rg 0.05 Tc 11.1292 0 0 9.9 169.81 417.37 Tm (of )Tj 0 Tc 10.8 0 0 10.8 181.25 417.37 Tm (8 )Tj ET BT /Suspect <>BDC 0.278 0.278 0.275 rg /T1_0 1 Tf 0.05 Tc 10.3096 0 0 9.9 188.16 417.37 Tm (/\267min )Tj EMC ET BT 0.572 0.577 0.565 rg /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 213.48 417.37 Tm (-)Tj 0.341 0.341 0.333 rg /T1_1 1 Tf 6.2 0 0 6.2 219.64 421.21 Tm (1)Tj 0.626 -0.619 Td (. )Tj 0.188 0.188 0.184 rg /T1_0 1 Tf 0.05 Tc 10.2656 0 0 9.9 227.91 417.37 Tm (The )Tj 0.341 0.341 0.333 rg 0.0308 Tc 9.9 0 0 9.9 247.06 417.37 Tm (solutions )Tj 0.278 0.278 0.275 rg 0.0171 Tc -19.09 -1.067 Td (were )Tj 0.341 0.341 0.333 rg 0.0218 Tc 2.466 0 Td (inhaled )Tj 0.278 0.278 0.275 rg 0.0451 Tc 3.489 0 Td (over )Tj 0.341 0.341 0.333 rg 0.0457 Tc 2.384 0 Td (ten )Tj 0.0202 Tc 1.689 0 Td (consecutive )Tj 0.278 0.278 0.275 rg 0.0316 Tc 5.384 0 Td (inspirations )Tj 0.0247 Tc 5.476 0 Td (from )Tj 0.0124 Tc -20.838 -1.116 Td (residual )Tj 0.0223 Tc 3.781 0 Td (volume )Tj 0.341 0.341 0.333 rg 0.05 Tc 10.2515 0 0 9.9 130.92 395.76 Tm (\(R )Tj 0.278 0.278 0.275 rg /T1_1 1 Tf 9.6441 0 0 9.2 142.07 395.76 Tm (V\) )Tj 0.341 0.341 0.333 rg /T1_0 1 Tf 0.0496 Tc 9.9 0 0 9.9 156.94 395.76 Tm (to )Tj 0.0298 Tc 1.309 0 Td (total )Tj 0.0269 Tc 2.418 0 Td (lung )Tj 0.278 0.278 0.275 rg 0.0333 Tc 2.228 0 Td (capacity )Tj 0.341 0.341 0.333 rg 0.0252 Tc 4.022 0 Td (\(TLC\). )Tj 0.278 0.278 0.275 rg 0.0478 Tc -19.92 -1.115 Td (During )Tj 0.341 0.341 0.333 rg 0.0272 Tc 3.485 0 Td (each )Tj 0.278 0.278 0.275 rg 0.0375 Tc 2.427 0 Td (inhalation )Tj 0.0215 Tc 4.903 0 Td (the )Tj 0.341 0.341 0.333 rg 0.0327 Tc 1.746 0 Td (respiratory )Tj 0.278 0.278 0.275 rg 0.0484 Tc 5.191 0 Td (pattern )Tj 0.001 Tc 3.585 0 Td (was )Tj 0.341 0.341 0.333 rg 0.0317 Tc -21.391 -1.114 Td (controlled )Tj 0.278 0.278 0.275 rg 0.0033 Tc 4.752 0 Td (as )Tj -0.0065 Tc 1.26 0 Td (follows: )Tj 0.341 0.341 0.333 rg 0 Tc 3.73 0 Td [(5 )-74(s )]TJ 0.278 0.278 0.275 rg 0.0311 Tc 1.606 0 Td (inspiration, )Tj 0 Tc 5.327 0 Td [(5 )-74(s )]TJ 0.0381 Tc 1.615 0 Td (breathhold )Tj 0.0355 Tc -18.29 -1.115 Td (and )Tj -0.0066 Tc 2.278 0 Td (free )Tj 0.341 0.341 0.333 rg 0.0156 Tc 2.279 0 Td (exp)Tj 0.188 0.188 0.184 rg 0.0305 Tc 1.506 0 Td (iration. )Tj 0.278 0.278 0.275 rg 0.0478 Tc 3.882 0 Td (During )Tj 0.0111 Tc 3.727 0 Td (each )Tj 0.0349 Tc 2.621 0 Td (inspiration )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0215 Tc 9.9 0 0 9.9 272.6116 362.6544 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0451 Tc 9.9 0 0 9.9 57.9796 352.0911 Tm (duration )Tj 0.05 Tc 10.5727 0 0 9.9 99.74 352.09 Tm (of )Tj 10.2128 0 0 9.9 112.7 352.09 Tm (drug )Tj 0.0116 Tc 9.9 0 0 9.9 137.67 352.09 Tm (delivery )Tj 0.001 Tc 3.887 0 Td (was )Tj 0.0157 Tc 2.072 0 Td (set )Tj 0.0496 Tc 1.709 0 Td (to )Tj -0.0317 Tc 1.422 0 Td (1.5 )Tj 0.341 0.341 0.333 rg 0 Tc 1.669 0 Td (s )Tj 0.278 0.278 0.275 rg 0.0162 Tc 0.935 0 Td (using )Tj 0 Tc 2.705 0 Td (a )Tj 0.039 Tc -22.437 -1.115 Td (breath-actuated )Tj 0.0222 Tc 7.064 0 Td (system )Tj 0.0358 Tc 3.204 0 Td (connected )Tj 0.341 0.341 0.333 rg 0.05 Tc 10.4772 0 0 9.9 206.37 341.05 Tm (to )Tj 0.278 0.278 0.275 rg 0.0215 Tc 9.9 0 0 9.9 218.86 341.05 Tm (the )Tj 0.0176 Tc 1.649 0 Td (nebulizer. )Tj 0.05 Tc 10.2656 0 0 9.9 67.11 330 Tm (The )Tj 0.0221 Tc 9.9 0 0 9.9 86.79 330 Tm (degree )Tj 0.05 Tc 11.6856 0 0 9.9 117.01 330 Tm (of )Tj 0.0387 Tc 9.9 0 0 9.9 129.13 330 Tm (bronchoconstriction )Tj 0.0252 Tc 9.016 0 Td (was )Tj 0.0098 Tc 1.882 0 Td (assessed )Tj -0.0207 Tc 3.841 0 Td (by )Tj 0.0258 Tc -21.918 -1.114 Td (measuring )Tj 0.05 Tc 9.9856 0 0 9.9 107 318.97 Tm (FEY )Tj 0.341 0.341 0.333 rg 0 Tc 6.5001 0 0 6.5001 127.94 316.56 Tm (1 )Tj 0.278 0.278 0.275 rg 0.0283 Tc 9.9 0 0 9.9 136.32 318.97 Tm (using )Tj 0 Tc 2.802 0 Td (a )Tj 0.341 0.341 0.333 rg 0.0399 Tc 0.966 0 Td (spirometer )Tj -0.0179 Tc 5.141 0 Td (\(Y)Tj 0.188 0.188 0.184 rg 0.042 Tc 1.071 0 Td (italograph)Tj 0.341 0.341 0.333 rg -0.035 Tc 9.0721 0 0 9.9 279.3 318.97 Tm (\). )Tj 0.278 0.278 0.275 rg 0.05 Tc 9.9723 0 0 9.9 57.51 307.93 Tm (The )Tj 0.0325 Tc 9.9 0 0 9.9 78.25 307.93 Tm (best )Tj 0.05 Tc 11.1292 0 0 9.9 98.77 307.93 Tm (of )Tj 0.0349 Tc 9.9 0 0 9.9 111.82 307.93 Tm (three )Tj 0.341 0.341 0.333 rg 0.003 Tc 2.558 0 Td (successive )Tj 0.278 0.278 0.275 rg 0.0143 Tc 4.667 0 Td (values )Tj 0.0379 Tc 3.095 0 Td (obtained )Tj 0.05 Tc 10.7518 0 0 9.9 254.77 307.93 Tm (at )Tj ET BT /Suspect <>BDC 0.341 0.341 0.333 rg /T1_0 1 Tf 0.0066 Tc 9.9 0 0 9.9 267.24 307.93 Tm (30 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 281.1396 307.93 Tm (s )Tj 0.278 0.278 0.275 rg 0.0206 Tc -22.588 -1.067 Td (intervals )Tj 0.0252 Tc 3.983 0 Td (was )Tj 0.0213 Tc 1.988 0 Td (retained. )Tj 0.0349 Tc -5.001 -1.115 Td (Tidal )Tj 0.032 Tc 2.576 0 Td (volume )Tj 0.341 0.341 0.333 rg -0.035 Tc 9.8799 0 0 9.9 127.08 286.33 Tm (\(YT\), )Tj 0.278 0.278 0.275 rg 0.0033 Tc 9.9 0 0 9.9 151.58 286.33 Tm (as )Tj -0.022 Tc 1.173 0 Td (well )Tj 0.341 0.341 0.333 rg 0.05 Tc 9.9203 0 0 9.9 182.78 286.33 Tm (as )Tj 0.278 0.278 0.275 rg 0.0215 Tc 9.9 0 0 9.9 195.34 286.33 Tm (the )Tj 0.0158 Tc 1.601 0 Td (relative )Tj 0.0416 Tc 3.385 0 Td (contribu\255)Tj 0.0239 Tc -18.901 -1.116 Td (tions )Tj 0.341 0.341 0.333 rg 0.05 Tc 11.1292 0 0 9.9 80.53 275.28 Tm (of )Tj 0.278 0.278 0.275 rg 0.0457 Tc 9.9 0 0 9.9 92.14 275.28 Tm (the )Tj 0.027 Tc 1.601 0 Td (rib )Tj 0.0435 Tc 1.397 0 Td (cage )Tj 0.05 Tc 9.9197 0 0 9.9 143.88 275.28 Tm (\(RC\) )Tj 0.341 0.341 0.333 rg 0.0355 Tc 9.9 0 0 9.9 167.9 275.28 Tm (and )Tj 0.05 Tc 11.1292 0 0 9.9 186.13 275.28 Tm (of )Tj 0.278 0.278 0.275 rg 0.0215 Tc 9.9 0 0 9.9 198.22 275.28 Tm (the )Tj 0.0459 Tc 1.543 0 Td (abdomen )Tj 0.038 Tc 4.265 0 Td (\(ABO\) )Tj 0.0496 Tc -20.014 -1.114 Td (to )Tj 0.341 0.341 0.333 rg 0.0457 Tc 1.6 0 Td (the )Tj 0.278 0.278 0.275 rg -0.035 Tc 9.3047 0 0 9.9 94.06 264.25 Tm (YT )Tj 0.0171 Tc 9.9 0 0 9.9 113.27 264.25 Tm (were )Tj 0.0287 Tc 2.763 0 Td (measured )Tj 0.0162 Tc 4.899 0 Td (using )Tj 0 Tc 2.996 0 Td (a )Tj 0.0247 Tc 1.221 0 Td (non-invasive )Tj 0.024 Tc -17.504 -1.115 Td (technique )Tj 0.0033 Tc 4.646 0 Td (as )Tj 0.0185 Tc 1.415 0 Td (recently )Tj 0.0257 Tc 3.871 0 Td (described )Tj 0.341 0.341 0.333 rg /T1_1 1 Tf 0.05 Tc 11.078 0 0 9.9 201.38 253.21 Tm ([II]. )Tj 0.278 0.278 0.275 rg /T1_0 1 Tf 10.0233 0 0 9.9 224.55 253.21 Tm (Two )Tj 0.0064 Tc 9.9 0 0 9.9 249.02 253.21 Tm (air-filled )Tj 0.0407 Tc -19.336 -1.067 Td (rubber )Tj 0.0089 Tc 3.251 0 Td (bellows )Tj 0.0397 Tc 3.623 0 Td (\(Pneumograph)Tj 0.431 0.435 0.423 rg 0 Tc 6.397 0 Td (, )Tj 0.278 0.278 0.275 rg 0.0314 Tc 0.692 0 Td (model )Tj ET BT /Suspect <>BDC 0.188 0.188 0.184 rg /T1_0 1 Tf 0.0131 Tc 9.5 0 0 9.5 226.71 242.65 Tm (108, )Tj EMC ET BT /T1_0 1 Tf 0.0219 Tc 9.9 0 0 9.9 248.11 242.65 Tm (Hewlett\255)Tj ET BT /Suspect <>BDC 0.278 0.278 0.275 rg /T1_0 1 Tf 0.0352 Tc 9.9 0 0 9.9 57.5647 231.6115 Tm (Packard\) )Tj EMC ET BT /T1_0 1 Tf 0.0171 Tc 9.9 0 0 9.9 98.8774 231.6115 Tm (were )Tj 0.0459 Tc 2.318 0 Td (attached )Tj 0.026 Tc 4.024 0 Td (circumferentially )Tj 0.05 Tc 10.0301 0 0 9.9 237.02 231.61 Tm (around )Tj 0.0215 Tc 9.9 0 0 9.9 271.66 231.61 Tm (the )Tj 0.0253 Tc -21.681 -1.115 Td (chest )Tj 0.05 Tc 10.1194 0 0 9.9 84.38 220.57 Tm (at )Tj 0.0215 Tc 9.9 0 0 9.9 98.86 220.57 Tm (the )Tj 0.188 0.188 0.184 rg -0.0206 Tc 1.933 0 Td (level )Tj 0.278 0.278 0.275 rg 0.05 Tc 11.1292 0 0 9.9 142.45 220.57 Tm (of )Tj 0.0215 Tc 9.9 0 0 9.9 157.9 220.57 Tm (the )Tj 0.0206 Tc 1.892 0 Td (nipples )Tj 0.05 Tc 10.0265 0 0 9.9 212.54 220.57 Tm (and )Tj 10.0301 0 0 9.9 234.62 220.57 Tm (around )Tj 0.0457 Tc 9.9 0 0 9.9 271.66 220.57 Tm (the )Tj 0.0459 Tc -21.681 -1.116 Td (abdomen )Tj 0.05 Tc 10.1194 0 0 9.9 103.58 209.52 Tm (at )Tj 0.0215 Tc 9.9 0 0 9.9 119.02 209.52 Tm (the )Tj 0.0135 Tc 2.087 0 Td (umbilical )Tj -0.018 Tc 4.646 0 Td (level. )Tj 0.0389 Tc 2.915 0 Td (Any )Tj 0.0394 Tc 2.513 0 Td (change )Tj 0.0149 Tc 3.735 0 Td (in )Tj 0.341 0.341 0.333 rg 0.0227 Tc -22.208 -1.114 Td (circumference )Tj 0.278 0.278 0.275 rg 0.05 Tc 11.1292 0 0 9.9 118.45 198.49 Tm (of )Tj 0.0215 Tc 9.9 0 0 9.9 130.06 198.49 Tm (the )Tj 0.0253 Tc 1.543 0 Td (chest )Tj 0.341 0.341 0.333 rg 0.05 Tc 10.5727 0 0 9.9 169.82 198.49 Tm (or )Tj 11.1292 0 0 9.9 181.33 198.49 Tm (of )Tj ET BT /Suspect <>BDC 0.278 0.278 0.275 rg /T1_0 1 Tf 0.0215 Tc 9.9 0 0 9.9 193.42 198.49 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0459 Tc 9.9 0 0 9.9 208.6957 198.49 Tm (abdomen )Tj 0.0331 Tc 4.269 0 Td (induced )Tj 0 Tc 10.9 0 0 10.9 57.01 187.93 Tm (a )Tj 0.0236 Tc 9.9 0 0 9.9 70 187.93 Tm (linear )Tj 0.341 0.341 0.333 rg 0.0357 Tc 3.255 0 Td (variation )Tj 0.278 0.278 0.275 rg 0.05 Tc 11.1292 0 0 9.9 148.69 187.93 Tm (of )Tj 0.0215 Tc 9.9 0 0 9.9 166.54 187.93 Tm (the )Tj 0.0383 Tc 2.077 0 Td (corresponding )Tj 0.0108 Tc 7.041 0 Td (bellow )Tj 0.0142 Tc -20.169 -1.115 Td (pressure. )Tj 0.05 Tc 9.9723 0 0 9.9 100.23 176.89 Tm (The )Tj 0.0272 Tc 9.9 0 0 9.9 122.9 176.89 Tm (pressures )Tj 0.0009 Tc 4.555 0 Td (were )Tj 0.0356 Tc 2.569 0 Td (measured )Tj 0.0283 Tc 4.705 0 Td (using )Tj 0.0274 Tc 2.907 0 Td (two )Tj 0.0163 Tc -21.437 -1.115 Td (differential )Tj 0.0349 Tc 5.389 0 Td (transducers )Tj 0.0196 Tc 5.614 0 Td (\(model )Tj -0.0133 Tc 3.691 0 Td (267 )Tj 0.188 0.188 0.184 rg 0.05 Tc 10.2323 0 0 9.9 224.11 165.85 Tm (BC)Tj 0.431 0.435 0.423 rg 0 Tc 9.9 0 0 9.9 237.93 165.85 Tm (, )Tj 0.278 0.278 0.275 rg 0.0289 Tc 0.98 0 Td (Hewlett\255)Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0298 Tc 9.9 0 0 9.9 57.0867 154.8016 Tm (Packard\), )Tj EMC ET BT /T1_0 1 Tf 0.0215 Tc 9.9 0 0 9.9 101.2704 154.8016 Tm (the )Tj 0.341 0.341 0.333 rg 0.0266 Tc 1.588 0 Td (signals )Tj 0.278 0.278 0.275 rg 0.05 Tc 11.1292 0 0 9.9 149.17 154.8 Tm (of )Tj 0.0088 Tc 9.9 0 0 9.9 161.75 154.8 Tm (which )Tj 0.0171 Tc 2.861 0 Td (were )Tj 0.0272 Tc 2.327 0 Td (recorded )Tj 0.05 Tc 10.2564 0 0 9.9 253.34 154.8 Tm (on )Tj 0.341 0.341 0.333 rg 0 Tc 9.9 0 0 9.9 267.74 154.8 Tm (a )Tj ET BT /Suspect <>BDC 0.278 0.278 0.275 rg /T1_0 1 Tf 0.0065 Tc 9.9 0 0 9.9 275.4818 154.8 Tm (4-)Tj EMC ET BT /T1_0 1 Tf 0.0271 Tc 9.9 0 0 9.9 56.5433 144.2466 Tm (cbannel )Tj 0.0339 Tc 3.552 0 Td (polygraph )Tj 0.0316 Tc 4.64 0 Td (\(Hewlett-Packard\), )Tj 0.05 Tc 10.3398 0 0 9.9 221.17 144.25 Tm (and )Tj 0.341 0.341 0.333 rg 0.0395 Tc 9.9 0 0 9.9 239.38 144.25 Tm (simu)Tj 0.188 0.188 0.184 rg 0.0431 Tc 2.091 0 Td (lt)Tj 0.341 0.341 0.333 rg 0.0287 Tc 0.58 0 Td (ane\255)Tj 0.278 0.278 0.275 rg 0.0212 Tc -21.139 -1.164 Td (ously )Tj 0.341 0.341 0.333 rg 0.05 Tc 10.4235 0 0 9.9 86.25 132.73 Tm (st)Tj 0.188 0.188 0.184 rg 0.0289 Tc 9.9 0 0 9.9 93.5 132.73 Tm (ored )Tj 0.278 0.278 0.275 rg 0.05 Tc 10.0265 0 0 9.9 119.9 132.73 Tm (and )Tj 0.0287 Tc 9.9 0 0 9.9 143.42 132.73 Tm (analysed )Tj 0.0386 Tc 4.509 0 Td (on )Tj 0 Tc 1.842 0 Td (a )Tj 0.0413 Tc 1.269 0 Td (microcomputer )Tj 0.0209 Tc -16.398 -1.068 Td (\(Apple )Tj 0.188 0.188 0.184 rg /T1_1 1 Tf 0.05 Tc 13.1112 0 0 10.1 87.48 122.16 Tm (II )Tj ET BT /Suspect <>BDC 0.278 0.278 0.275 rg /T1_0 1 Tf 0.0075 Tc 9.9 0 0 9.9 97.88 122.16 Tm (Plus\). )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.9723 0 0 9.9 123.75 122.16 Tm (The )Tj 0.0316 Tc 9.9 0 0 9.9 141.97 122.16 Tm (frequency )Tj 0.0269 Tc 4.568 0 Td (response )Tj 0.05 Tc 11.6856 0 0 9.9 225.97 122.16 Tm (of )Tj 0.0215 Tc 9.9 0 0 9.9 237.58 122.16 Tm (the )Tj 0.341 0.341 0.333 rg 0.0253 Tc 1.491 0 Td (system, )Tj 0.278 0.278 0.275 rg 0.0212 Tc -19.776 -1.115 Td (including )Tj 0.0215 Tc 4.273 0 Td (the )Tj 0.0424 Tc 1.552 0 Td (tubing )Tj 0.0037 Tc 3.105 0 Td (used )Tj 0.0135 Tc 2.219 0 Td (for )Tj 0.0301 Tc 1.504 0 Td (connections, )Tj 0.0252 Tc 5.633 0 Td (was )Tj -0.035 Tc 9.4863 0 0 9.9 256.78 111.12 Tm (Aat )Tj 0.0188 Tc 9.9 0 0 9.9 273.6 111.12 Tm (up )Tj 0.0496 Tc -21.917 -1.115 Td (to )Tj 0.05 Tc 10.8215 0 0 9.9 68.51 100.08 Tm (6Hz. )Tj 9.9723 0 0 9.9 321.03 755.76 Tm (The )Tj 0.0356 Tc 9.9 0 0 9.9 343.58 755.76 Tm (calibration )Tj 0.05 Tc 10.5727 0 0 9.9 395.9 755.76 Tm (of )Tj 0.0457 Tc 9.9 0 0 9.9 410.86 755.76 Tm (the )Tj 0.0432 Tc 1.943 0 Td (pneumographs )Tj 0.0252 Tc 7.027 0 Td (was )Tj 0.0162 Tc 2.282 0 Td (per\255)Tj 0.0202 Tc -21.298 -1.114 Td (formed )Tj 0.0162 Tc 3.308 0 Td (using )Tj 0.0457 Tc 2.422 0 Td (the )Tj 0.0193 Tc 1.497 0 Td (least )Tj 0.341 0.341 0.333 rg 0.0459 Tc 2.079 0 Td (square )Tj 0.278 0.278 0.275 rg 0.0415 Tc 3.018 0 Td (method )Tj -0.0338 Tc 3.469 0 Td ([12\). )Tj 0.05 Tc 10.2656 0 0 9.9 487.59 744.73 Tm (The )Tj 0.0278 Tc 9.9 0 0 9.9 506.26 744.73 Tm (subject, )Tj 0.0301 Tc -19.72 -1.116 Td (wearing )Tj 0 Tc 3.627 0 Td (a )Tj 0.0136 Tc 0.785 0 Td (noseclip, )Tj -0.0233 Tc 4.024 0 Td (was )Tj 0.0297 Tc 1.785 0 Td (connected )Tj 0.0496 Tc 4.614 0 Td (to )Tj 0 Tc 1.156 0 Td (a )Tj 0.0454 Tc 0.788 0 Td (pneumotacho\255)Tj 0.05 Tc 9.946 0 0 9.9 311.44 723.12 Tm (graph )Tj 0.0209 Tc 9.9 0 0 9.9 338.76 723.12 Tm (\(Fleisch )Tj 0.0397 Tc 3.701 0 Td (No. )Tj 0.0101 Tc 1.929 0 Td (2\) )Tj 0.341 0.341 0.333 rg 0.0496 Tc 1.168 0 Td (th)Tj 0.188 0.188 0.184 rg 0.035 Tc 0.874 0 Td (rough )Tj 0.278 0.278 0.275 rg 0 Tc 2.852 0 Td (a )Tj 0.043 Tc 0.784 0 Td (mouthpiece )Tj 0.05 Tc 10.3398 0 0 9.9 503.41 723.12 Tm (and )Tj 0.001 Tc 9.9 0 0 9.9 523.19 723.12 Tm (was )Tj 0.341 0.341 0.333 rg 0.028 Tc -21.439 -1.114 Td (asked )Tj 0.0011 Tc 2.966 0 Td (to )Tj 0.278 0.278 0.275 rg 0.0387 Tc 1.362 0 Td (produce )Tj 0.188 0.188 0.184 rg -0.035 Tc 9.3047 0 0 9.9 392.62 712.09 Tm (YT )Tj 0.278 0.278 0.275 rg 0.05 Tc 11.1292 0 0 9.9 409.33 712.09 Tm (of )Tj 0.0197 Tc 9.9 0 0 9.9 422.79 712.09 Tm (different )Tj 0.0336 Tc 4.08 0 Td (magnitudes, )Tj 0.0236 Tc 5.722 0 Td (with )Tj 0.0197 Tc -21.099 -1.115 Td (different )Tj 0.039 Tc 3.926 0 Td (contributions )Tj 0.05 Tc 11.1292 0 0 9.9 410.77 701.05 Tm (of )Tj 10.0892 0 0 9.9 423.79 701.05 Tm (RC )Tj 10.0265 0 0 9.9 441.5 701.05 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0395 Tc 9.9 0 0 9.9 461.74 701.05 Tm (ABO. )Tj EMC ET BT 0.188 0.188 0.184 rg /T1_0 1 Tf 0.05 Tc 10.0214 0 0 9.9 490.99 701.05 Tm (During )Tj 0.341 0.341 0.333 rg 0.0215 Tc 9.9 0 0 9.9 525.58 701.05 Tm (ten )Tj 0.003 Tc -21.685 -1.068 Td (successive )Tj 0.278 0.278 0.275 rg 0.046 Tc 5.058 0 Td (breaths )Tj 0.341 0.341 0.333 rg 0.0215 Tc 3.973 0 Td (the )Tj 0.278 0.278 0.275 rg 0.0322 Tc 2.079 0 Td (integrated )Tj 0.0266 Tc 5.133 0 Td (signals )Tj 0.05 Tc 11.1292 0 0 9.9 508.69 690.48 Tm (of )Tj 0.341 0.341 0.333 rg 0.0457 Tc 9.9 0 0 9.9 525.58 690.48 Tm (the )Tj 0.0434 Tc -21.669 -1.115 Td (pneumotachog)Tj 0.188 0.188 0.184 rg 0.0384 Tc 6.397 0 Td (raph )Tj 0.278 0.278 0.275 rg 0.0009 Tc 2.764 0 Td (were )Tj 0.0127 Tc 2.755 0 Td (collected )Tj 0.341 0.341 0.333 rg 0.0438 Tc 4.554 0 Td (simultaneo)Tj 0.188 0.188 0.184 rg 0 Tc 4.814 0 Td (u)Tj 0.341 0.341 0.333 rg -0.0128 Tc 0.519 0 Td (sly )Tj 0.0236 Tc -21.805 -1.114 Td (with )Tj 0.278 0.278 0.275 rg 0.0215 Tc 2.472 0 Td (the )Tj 0.0243 Tc 1.846 0 Td (pressure )Tj 0.0185 Tc 4.057 0 Td (signals )Tj 0.0086 Tc 3.494 0 Td (from )Tj 0.0457 Tc 2.627 0 Td (the )Tj 0.0134 Tc 1.894 0 Td (bellows. )Tj 0.0382 Tc 4.064 0 Td (These )Tj 0.341 0.341 0.333 rg 0.0104 Tc -20.467 -1.116 Td (signals )Tj 0.278 0.278 0.275 rg 0.0171 Tc 3.213 0 Td (were )Tj 0.0231 Tc 2.314 0 Td (sampled )Tj 0.341 0.341 0.333 rg 0.05 Tc 10.7518 0 0 9.9 403.57 657.36 Tm (at )Tj ET BT /Suspect <>BDC 0.278 0.278 0.275 rg /T1_0 1 Tf -0.0114 Tc 9.9 0 0 9.9 415.14 657.36 Tm (20 )Tj EMC ET BT 0.188 0.188 0.184 rg /T1_0 1 Tf 0.0098 Tc 9.9 0 0 9.9 429.0693 657.36 Tm (Hz)Tj 0.341 0.341 0.333 rg 0 Tc 1.202 0 Td (, )Tj 0.278 0.278 0.275 rg 0.016 Tc 0.588 0 Td (digitized, )Tj 0.001 Tc 4.313 0 Td (filtered )Tj 0.05 Tc 10.3398 0 0 9.9 522.13 657.36 Tm (and )Tj 0.341 0.341 0.333 rg 0.0218 Tc 9.9 0 0 9.9 310.94 646.8 Tm (analysed )Tj 0.278 0.278 0.275 rg -0.0207 Tc 3.938 0 Td (by )Tj 0.0215 Tc 1.209 0 Td (the )Tj 0.0372 Tc 1.503 0 Td (microcomputer )Tj 0.341 0.341 0.333 rg 0.0377 Tc 6.73 0 Td (for )Tj 0.278 0.278 0.275 rg 0.05 Tc 9.9965 0 0 9.9 457.34 646.8 Tm (computation )Tj 11.1292 0 0 9.9 514.45 646.8 Tm (of )Tj 10.2 0 0 9.9 525.1 646.8 Tm (the )Tj 0.0356 Tc 9.9 0 0 9.9 310.46 635.76 Tm (calibration )Tj 0.341 0.341 0.333 rg 0.0206 Tc 5.284 0 Td (factors )Tj 0.05 Tc 11.1292 0 0 9.9 397.33 635.76 Tm (of )Tj 0.188 0.188 0.184 rg 10.785 0 0 9.9 411.79 635.76 Tm (RC )Tj 0.278 0.278 0.275 rg 0.0355 Tc 9.9 0 0 9.9 432.86 635.76 Tm (and )Tj 0.0395 Tc 2.19 0 Td (ABO, )Tj 0.0405 Tc 3.105 0 Td (using )Tj 0.0333 Tc 2.95 0 Td (linear )Tj 0.0124 Tc -20.551 -1.114 Td (regression )Tj 0.0164 Tc 4.548 0 Td (analysis. )Tj 0.0382 Tc 3.881 0 Td (These )Tj 0.0206 Tc 2.858 0 Td (factors )Tj 0.0171 Tc 3.162 0 Td (were )Tj 0.341 0.341 0.333 rg 0.0416 Tc 2.326 0 Td (then )Tj 0.278 0.278 0.275 rg 0.0445 Tc 2.133 0 Td (manually )Tj 0.0157 Tc -18.97 -1.067 Td (set )Tj 0.0477 Tc 1.564 0 Td (through )Tj 0.0369 Tc 3.782 0 Td (manipulation )Tj 0.341 0.341 0.333 rg 0.05 Tc 10.5727 0 0 9.9 423.74 614.17 Tm (of )Tj 0.278 0.278 0.275 rg 0.0215 Tc 9.9 0 0 9.9 436.3 614.17 Tm (the )Tj 0.0237 Tc 1.653 0 Td (preamplifier )Tj 0.0295 Tc 5.566 0 Td (gain )Tj 0.05 Tc 11.1292 0 0 9.9 529.33 614.17 Tm (of )Tj 10.4371 0 0 9.9 310.99 603.12 Tm (RC )Tj 10.0265 0 0 9.9 328.7 603.12 Tm (and )Tj 10.0173 0 0 9.9 347.98 603.12 Tm (ABO )Tj 0.0192 Tc 9.9 0 0 9.9 373.34 603.12 Tm (channels. )Tj 0.188 0.188 0.184 rg 0.05 Tc 10.2656 0 0 9.9 415.11 603.12 Tm (The )Tj 0.278 0.278 0.275 rg 9.9441 0 0 9.9 435.26 603.12 Tm (computer )Tj 0.001 Tc 9.9 0 0 9.9 479.51 603.12 Tm (was )Tj 0.033 Tc 1.93 0 Td (also )Tj 0.0037 Tc 2.095 0 Td (used )Tj 0.0377 Tc -21.102 -1.114 Td (for )Tj 0.0295 Tc 1.989 0 Td (calculation )Tj 0.05 Tc 11.1292 0 0 9.9 384.37 592.09 Tm (of )Tj 0.0215 Tc 9.9 0 0 9.9 400.78 592.09 Tm (the )Tj 0.0298 Tc 2.036 0 Td (means )Tj 0.05 Tc 10.5727 0 0 9.9 455.42 592.09 Tm (of )Tj 0.188 0.188 0.184 rg 10.2 0 0 9.9 471.34 592.09 Tm (the )Tj 0.278 0.278 0.275 rg 0.0322 Tc 9.9 0 0 9.9 492.5 592.09 Tm (percentage )Tj 0.0091 Tc -18.387 -1.067 Td (difference )Tj 0.0126 Tc 4.422 0 Td (between )Tj 0.0265 Tc 3.633 0 Td (volumes )Tj 0.0448 Tc 3.774 0 Td (obtained )Tj 0.0247 Tc 4.023 0 Td (from )Tj 0.188 0.188 0.184 rg 0.0215 Tc 2.385 0 Td (the )Tj 0.278 0.278 0.275 rg 0.0169 Tc 1.555 0 Td (bellows )Tj 0.341 0.341 0.333 rg 0.05 Tc 10.3398 0 0 9.9 310.45 570.48 Tm (and )Tj 0.278 0.278 0.275 rg 0.0086 Tc 9.9 0 0 9.9 332.05 570.48 Tm (from )Tj 0.0457 Tc 2.627 0 Td (the )Tj 0.0426 Tc 1.846 0 Td (pneumotachograph. )Tj 0.0474 Tc 9.2 0 Td (Calibration )Tj 0.0252 Tc 5.536 0 Td (was )Tj 0.0222 Tc -21.391 -1.115 Td (accepted )Tj 0.05 Tc 10.4373 0 0 9.9 351.75 559.44 Tm (if )Tj 0.0208 Tc 9.9 0 0 9.9 362.86 559.44 Tm (this )Tj 0.0215 Tc 2.04 0 Td (percentage )Tj 0.0091 Tc 4.983 0 Td (difference )Tj 0.0252 Tc 4.663 0 Td (was )Tj 0.341 0.341 0.333 rg -0.0094 Tc 2.078 0 Td (less )Tj 0.278 0.278 0.275 rg 0.05 Tc 10.0233 0 0 9.9 518.86 559.44 Tm (than )Tj 0.0162 Tc 9.9 0 0 9.9 311.18 548.89 Tm (10% )Tj 0.0451 Tc 2.206 0 Td (over )Tj 0 Tc 2.182 0 Td (a )Tj 0.0006 Tc 0.785 0 Td (wide )Tj 0.0271 Tc 2.279 0 Td (range )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.2502 0 0 9.9 411.26 548.89 Tm (ofVT )Tj EMC ET BT 0.341 0.341 0.333 rg /T1_0 1 Tf 0.0459 Tc 9.9 0 0 9.9 437.64 548.89 Tm (\(about )Tj ET BT /Suspect <>BDC 0.278 0.278 0.275 rg /T1_0 1 Tf 0.011 Tc 9.9 0 0 9.9 468.4191 548.89 Tm (200 )Tj EMC ET BT 0.341 0.341 0.333 rg /T1_0 1 Tf 0.0496 Tc 9.9 0 0 9.9 486.6945 548.89 Tm (to )Tj ET BT /Suspect <>BDC 0.278 0.278 0.275 rg /T1_0 1 Tf -0.0126 Tc 9.9 0 0 9.9 498.8517 548.89 Tm (1500 )Tj EMC ET BT /T1_0 1 Tf -0.0109 Tc 9.9 0 0 9.9 521.2554 548.89 Tm (ml\). )Tj 0.0432 Tc -20.318 -1.115 Td (Respiratory )Tj 0.0194 Tc 6.055 0 Td (frequency )Tj 0.0155 Tc 9.4 0 0 9.4 430.93 537.85 Tm (\(f\), )Tj 0.0376 Tc 9.9 0 0 9.9 453.1 537.85 Tm (minute )Tj 0.0292 Tc 3.976 0 Td (ventilation )Tj ET BT /Suspect <>BDC 0.341 0.341 0.333 rg /T1_0 1 Tf -0.035 Tc 8.5311 0 0 10.3 309.99 526.8 Tm (CVE\), )Tj EMC ET BT 0.278 0.278 0.275 rg /T1_0 1 Tf 0.0342 Tc 9.9 0 0 9.9 337.84 526.8 Tm (inspiratory )Tj 0.0074 Tc 5.388 0 Td (time )Tj 0.341 0.341 0.333 rg -0.029 Tc 10.3 0 0 10.3 416.04 526.8 Tm (\(TI\), )Tj 0.0416 Tc 9.9 0 0 9.9 441.01 526.8 Tm (expiratory )Tj 0.278 0.278 0.275 rg 0.0236 Tc 5.197 0 Td (time )Tj -0.0202 Tc 2.511 0 Td (\(TE\), )Tj 0.0401 Tc -20.935 -1.115 Td (mean )Tj 0.188 0.188 0.184 rg 0.045 Tc 2.612 0 Td (inspirator)Tj 0.341 0.341 0.333 rg 0 Tc 4.225 0 Td (y )Tj 0.278 0.278 0.275 rg -0.0191 Tc 0.766 0 Td (flow )Tj 0.341 0.341 0.333 rg -0.0079 Tc 2.084 0 Td (\(VT/TI\), )Tj 0.278 0.278 0.275 rg 0.039 Tc 3.737 0 Td (inspiratory )Tj 0.341 0.341 0.333 rg 0.0228 Tc 5.039 0 Td (fract)Tj 0.188 0.188 0.184 rg 0.0241 Tc 1.991 0 Td (ion )Tj 0.278 0.278 0.275 rg 0.05 Tc 10.5727 0 0 9.9 529.34 515.76 Tm (of )Tj 0.0215 Tc 9.9 0 0 9.9 310.54 504.72 Tm (the )Tj 0.0458 Tc 1.797 0 Td (breath )Tj -0.0003 Tc 3.189 0 Td (cycle )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0337 Tc 9.9 0 0 9.9 385.3246 504.72 Tm (\(Tr/T)Tj -0.0084 Tc 5.1 0 0 5.1 407.83 502.81 Tm (101)Tj 0 Tc 1.533 0.375 Td (\) )Tj EMC ET BT 0.341 0.341 0.333 rg /T1_0 1 Tf 9.9 0 0 9.9 423.74 504.72 Tm (a)Tj 0.188 0.188 0.184 rg 0.0215 Tc 0.494 0 Td (nd )Tj 0.278 0.278 0.275 rg 1.599 0 Td (the )Tj 0.0296 Tc 1.746 0 Td (relative )Tj 0.0477 Tc 3.627 0 Td (contribu\255)Tj 0.036 Tc -18.95 -1.067 Td (tions )Tj 0.341 0.341 0.333 rg 0.05 Tc 11.6856 0 0 9.9 334.45 494.16 Tm (of )Tj 0.188 0.188 0.184 rg 10.0892 0 0 9.9 347.95 494.16 Tm (RC )Tj 0.278 0.278 0.275 rg 10.0265 0 0 9.9 366.14 494.16 Tm (and )Tj 0.188 0.188 0.184 rg 10.0173 0 0 9.9 385.9 494.16 Tm (ABO )Tj 0.341 0.341 0.333 rg 0.0496 Tc 9.9 0 0 9.9 412.3 494.16 Tm (to )Tj ET BT /Suspect <>BDC 0.278 0.278 0.275 rg /T1_0 1 Tf -0.035 Tc 9.6716 0 0 9.9 424.3 494.16 Tm (VT )Tj EMC ET BT /T1_0 1 Tf 0.0171 Tc 9.9 0 0 9.9 440.63 494.16 Tm (were )Tj 0.0274 Tc 2.368 0 Td (derived )Tj 0.0247 Tc 3.634 0 Td (from )Tj 0.0215 Tc 2.53 0 Td (the )Tj 0.341 0.341 0.333 rg 0.0306 Tc -21.733 -1.115 Td (stored )Tj 0.278 0.278 0.275 rg 0.05 Tc 10.0381 0 0 9.9 338.79 483.12 Tm (data. )Tj 0.0362 Tc 9.9 0 0 9.9 363.26 483.12 Tm (Changes )Tj -0.0336 Tc 3.978 0 Td (in )Tj 0.0399 Tc 1.064 0 Td (end)Tj 0.431 0.435 0.423 rg 0 Tc 1.55 0 Td (-)Tj 0.278 0.278 0.275 rg 0.0298 Tc 0.35 0 Td (tidal )Tj 0.0223 Tc 2.23 0 Td (volume )Tj 0.0315 Tc 3.384 0 Td (\(ETY\) )Tj 0.0009 Tc 3.114 0 Td (were )Tj 0.0274 Tc -21.099 -1.114 Td (derived )Tj 0.0409 Tc 3.537 0 Td (from )Tj 0.0457 Tc 2.433 0 Td (the )Tj 0.0327 Tc 1.592 0 Td (changes )Tj 0.0149 Tc 3.735 0 Td (in )Tj 0.0339 Tc 1.161 0 Td (end-expiratory )Tj 0.0348 Tc 6.704 0 Td (positions )Tj 0.05 Tc 10.5727 0 0 9.9 309.98 461.53 Tm (of )Tj 10.785 0 0 9.9 322.03 461.53 Tm (RC )Tj 10.0265 0 0 9.9 340.22 461.53 Tm (and )Tj -0.035 Tc 9.5702 0 0 9.9 359.5 461.53 Tm (YT. )Tj 0.05 Tc 9.9723 0 0 9.9 319.59 450.49 Tm (The )Tj 0.0218 Tc 9.9 0 0 9.9 342.58 450.49 Tm (subjects )Tj 0.0171 Tc 4.037 0 Td (were )Tj 0.341 0.341 0.333 rg 0.036 Tc 2.605 0 Td (supine )Tj 0.278 0.278 0.275 rg 0.05 Tc 10.2564 0 0 9.9 441.98 450.49 Tm (on )Tj 0 Tc 9.9 0 0 9.9 459.26 450.49 Tm (a )Tj 0.0348 Tc 1.223 0 Td (bed )Tj 0.05 Tc 9.9334 0 0 9.9 492.39 450.49 Tm (during )Tj 0.0161 Tc 9.9 0 0 9.9 526.94 450.49 Tm (all )Tj 0.0363 Tc -21.956 -1.116 Td (measurements )Tj 0.05 Tc 10.3398 0 0 9.9 375.25 439.44 Tm (and )Tj 0.0418 Tc 9.9 0 0 9.9 396.46 439.44 Tm (manipulations)Tj 0.431 0.435 0.423 rg 0 Tc 6.193 0 Td (, )Tj 0.278 0.278 0.275 rg 0.0272 Tc 0.783 0 Td (including )Tj 0.0191 Tc 4.555 0 Td (forced )Tj 0.341 0.341 0.333 rg 0.0362 Tc -20.315 -1.114 Td (expiratory )Tj 0.278 0.278 0.275 rg 0.0351 Tc 4.858 0 Td (manoeuvres )Tj 0.05 Tc 10.0265 0 0 9.9 412.22 428.41 Tm (and )Tj 0.022 Tc 9.9 0 0 9.9 432.38 428.41 Tm (aerosol )Tj 0.188 0.188 0.184 rg 0.0385 Tc 3.493 0 Td (inhalations)Tj 0.341 0.341 0.333 rg 0 Tc 4.835 0 Td (. )Tj 0.278 0.278 0.275 rg 0.05 Tc 9.9723 0 0 9.9 520.71 428.41 Tm (The )Tj 0.0407 Tc 9.9 0 0 9.9 310.07 417.37 Tm (rubber )Tj 0.0169 Tc 3.687 0 Td (bellows )Tj 0.039 Tc 4.013 0 Td (attached )Tj 0.05 Tc 10.1893 0 0 9.9 430.94 417.37 Tm (around )Tj 0.0457 Tc 9.9 0 0 9.9 470.38 417.37 Tm (the )Tj 0.0253 Tc 2.125 0 Td (chest )Tj 0.0355 Tc 3.055 0 Td (and )Tj 0.05 Tc 9.9597 0 0 9.9 309.5 406.81 Tm (abdomen )Tj 0.0171 Tc 9.9 0 0 9.9 351.35 406.81 Tm (were )Tj 0.0295 Tc 2.278 0 Td (taped )Tj 0.0496 Tc 2.618 0 Td (to )Tj 0.0296 Tc 1.059 0 Td (avoid )Tj 0.05 Tc 10.0265 0 0 9.9 436.22 406.81 Tm (any )Tj 0.0257 Tc 9.9 0 0 9.9 453.99 406.81 Tm (displacement. )Tj 0.0441 Tc 6.116 0 Td (After )Tj 0.341 0.341 0.333 rg 0.0356 Tc -20.711 -1.116 Td (calibration )Tj 0.278 0.278 0.275 rg 0.05 Tc 11.6856 0 0 9.9 361.33 395.76 Tm (of )Tj 0.0457 Tc 9.9 0 0 9.9 376.78 395.76 Tm (the )Tj 0.0125 Tc 1.879 0 Td (system)Tj 0.431 0.435 0.423 rg 0 Tc 2.908 0 Td (, )Tj 0.278 0.278 0.275 rg 0.0033 Tc 0.878 0 Td (as )Tj -0.022 Tc 1.464 0 Td (well )Tj 0.341 0.341 0.333 rg 0.05 Tc 9.9203 0 0 9.9 470.3 395.76 Tm (as )Tj 0.278 0.278 0.275 rg 0.0346 Tc 9.9 0 0 9.9 485.29 395.76 Tm (before )Tj 0.0434 Tc 3.285 0 Td (each )Tj 0.0342 Tc -21.029 -1.115 Td (period )Tj 0.341 0.341 0.333 rg 0.05 Tc 11.1292 0 0 9.9 339.73 384.72 Tm (of )Tj 0.278 0.278 0.275 rg 0.0209 Tc 9.9 0 0 9.9 352.31 384.72 Tm (recording, )Tj 0.0457 Tc 4.654 0 Td (the )Tj 0.341 0.341 0.333 rg 0 Tc 1.636 0 Td (s)Tj 0.188 0.188 0.184 rg 0.0163 Tc 0.402 0 Td (ubj)Tj 0.341 0.341 0.333 rg 0.0064 Tc 1.346 0 Td (ects )Tj 0.278 0.278 0.275 rg 0.0009 Tc 1.95 0 Td (were )Tj 0.341 0.341 0.333 rg 0.0243 Tc 2.27 0 Td (allowed )Tj 0.278 0.278 0.275 rg 0.0496 Tc 3.693 0 Td (to )Tj 0.0204 Tc 1.213 0 Td (rest )Tj 0.0377 Tc -21.489 -1.114 Td (for )Tj 0.341 0.341 0.333 rg 0 Tc 1.75 0 Td (2)Tj 0.572 0.577 0.565 rg 0.479 0 Td (-)Tj 0.341 0.341 0.333 rg 0.63 0 Td (3 )Tj 0.278 0.278 0.275 rg 0.0143 Tc 0.931 0 Td (min. )Tj 0.188 0.188 0.184 rg 0.05 Tc 10.4635 0 0 9.9 370.51 373.69 Tm (Data )Tj 0.278 0.278 0.275 rg 0.0009 Tc 9.9 0 0 9.9 396.47 373.69 Tm (were )Tj 0.341 0.341 0.333 rg 0.0215 Tc 2.472 0 Td (the)Tj 0.188 0.188 0.184 rg 0 Tc 1.31 0 Td (n )Tj 0.278 0.278 0.275 rg 0.0188 Tc 0.961 0 Td (collected )Tj 0.0451 Tc 4.218 0 Td (over )Tj 0 Tc 2.372 0 Td (5 )Tj 0.0305 Tc 0.933 0 Td (min, )Tj 0.0338 Tc -21.1 -1.115 Td (everything )Tj 0.0171 Tc 4.861 0 Td (being )Tj 0.0366 Tc 2.608 0 Td (quiet )Tj 0.0149 Tc 2.425 0 Td (in )Tj 0.0457 Tc 1.17 0 Td (the )Tj 0.0404 Tc 1.601 0 Td (room. )Tj 0.341 0.341 0.333 rg 0.05 Tc 10.5656 0 0 9.9 462.77 362.65 Tm (No )Tj 0.278 0.278 0.275 rg 0.0434 Tc 9.9 0 0 9.9 479.42 362.65 Tm (attention )Tj 0.001 Tc 4.227 0 Td (was )Tj 0.0276 Tc -21.379 -1.067 Td (paid )Tj 0.0496 Tc 2.226 0 Td (to )Tj 0.0457 Tc 1.212 0 Td (the )Tj 0.0444 Tc 1.698 0 Td (route )Tj 0.05 Tc 11.1292 0 0 9.9 385.81 352.09 Tm (of )Tj 0.0281 Tc 9.9 0 0 9.9 398.41 352.09 Tm (breathing. )Tj /T1_2 1 Tf 0.0225 Tc 10.1 0 0 10.1 309.1 324.25 Tm (Statistical )Tj 0.0019 Tc 4.51 0 Td (analysis )Tj /T1_0 1 Tf 0.05 Tc 10.4358 0 0 9.9 319.63 307.93 Tm (For )Tj 0.0215 Tc 9.9 0 0 9.9 342.7 307.93 Tm (the )Tj 0.0391 Tc 2.028 0 Td (comparison )Tj 0.0126 Tc 5.829 0 Td (between )Tj 0.0454 Tc 4.168 0 Td (nonsmokers )Tj 0.05 Tc 10.3398 0 0 9.9 520.69 307.93 Tm (and )Tj 0.0389 Tc 9.9 0 0 9.9 308.98 296.89 Tm (smokers )Tj 0.05 Tc 10.2654 0 0 9.9 349.34 296.89 Tm (an )Tj 0.0409 Tc 9.9 0 0 9.9 365.28 296.89 Tm (unpaired )Tj 0.0376 Tc 4.313 0 Td (t-test )Tj 0.001 Tc 2.716 0 Td (was )Tj 0.013 Tc 2.134 0 Td (used. )Tj 0.188 0.188 0.184 rg 0.0284 Tc 2.712 0 Td (Within )Tj 0.278 0.278 0.275 rg 0.0434 Tc 3.483 0 Td (each )Tj 0.05 Tc 9.9115 0 0 9.9 309.04 286.33 Tm (group )Tj 11.6856 0 0 9.9 336.37 286.33 Tm (of )Tj 0.0218 Tc 9.9 0 0 9.9 347.86 286.33 Tm (subjects )Tj 0.0457 Tc 3.648 0 Td (the )Tj 0.0391 Tc 1.543 0 Td (comparison )Tj 0.0288 Tc 5.296 0 Td (between )Tj 0.0456 Tc 3.734 0 Td (paired )Tj 0.05 Tc 10.377 0 0 9.9 517.82 286.33 Tm (data )Tj 0.0252 Tc 9.9 0 0 9.9 309.11 275.28 Tm (was )Tj 0.0098 Tc 1.93 0 Td (assessed )Tj 0.0041 Tc 3.889 0 Td (using )Tj 0.341 0.341 0.333 rg 0.0262 Tc 2.572 0 Td (paired )Tj 0.278 0.278 0.275 rg 0.0139 Tc 3.051 0 Td (t-test. )Tj 0.0207 Tc 2.715 0 Td (Analysis )Tj 0.05 Tc 11.1292 0 0 9.9 489.01 275.28 Tm (of )Tj 0.0302 Tc 9.9 0 0 9.9 501.1 275.28 Tm (variance )Tj 0.341 0.341 0.333 rg 0.0377 Tc -19.403 -1.114 Td (for )Tj 0.278 0.278 0.275 rg 0.0364 Tc 1.998 0 Td (repeated )Tj 0.0363 Tc 4.363 0 Td (measurements )Tj 0.0252 Tc 6.837 0 Td (was )Tj 0.0198 Tc 2.328 0 Td (used )Tj 0.0377 Tc 2.656 0 Td (for )Tj 0.341 0.341 0.333 rg 0.0252 Tc 1.997 0 Td (testing )Tj 0.278 0.278 0.275 rg 0.013 Tc -20.225 -1.115 Td (differences )Tj 0.0207 Tc 4.859 0 Td (between )Tj 0.0422 Tc 3.734 0 Td (parameters )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0448 Tc 9.9 0 0 9.9 443.4226 253.2129 Tm (obtained )Tj EMC ET BT /T1_0 1 Tf 0.0235 Tc 9.9 0 0 9.9 483.2206 253.2129 Tm (sequentially. )Tj 0 Tc 9.4 0 0 9.4 309.13 242.65 Tm (p )Tj 0.341 0.341 0.333 rg 0.05 Tc 10.1707 0 0 9.9 316.27 242.65 Tm (<0.05 )Tj 0.278 0.278 0.275 rg 0.001 Tc 9.9 0 0 9.9 345.59 242.65 Tm (was )Tj 0.0277 Tc 1.93 0 Td (considered )Tj 0.341 0.341 0.333 rg 0.0233 Tc 4.941 0 Td (statistically )Tj 0.278 0.278 0.275 rg 0.0106 Tc 5.188 0 Td (significant. )Tj 0.0092 Tc 10.1 0 0 10.1 407.47 214.8 Tm (Results )Tj 0.0355 Tc 9.9 0 0 9.9 318.65 198.97 Tm (Individual )Tj 0.0299 Tc 5.427 0 Td (characteristics )Tj 0.05 Tc 11.1292 0 0 9.9 443.41 198.97 Tm (of )Tj 0.0215 Tc 9.9 0 0 9.9 462.7 198.97 Tm (the )Tj 0.0437 Tc 2.331 0 Td (populations )Tj 0.341 0.341 0.333 rg 0.0335 Tc -17.907 -1.115 Td (studied, )Tj 0.278 0.278 0.275 rg 0.04 Tc 3.843 0 Td (nonsmokers )Tj 0.0355 Tc 5.712 0 Td (and )Tj 0.341 0.341 0.333 rg 0.0254 Tc 2.032 0 Td (smokers, )Tj 0.278 0.278 0.275 rg 0.05 Tc 9.9087 0 0 9.9 465.5 187.93 Tm (are )Tj 0.0257 Tc 9.9 0 0 9.9 483.38 187.93 Tm (presented )Tj 0.0149 Tc 4.547 0 Td (in )Tj 0.341 0.341 0.333 rg 0.05 Tc 10.2 0 0 9.9 308.62 176.89 Tm (tab)Tj 0.188 0.188 0.184 rg -0.026 Tc 9.9 0 0 9.9 322.48 176.89 Tm (le )Tj 0.278 0.278 0.275 rg -0.035 Tc 8.9497 0 0 9.5 334.25 176.89 Tm (1. )Tj 0.04 Tc 9.9 0 0 9.9 345.04 176.89 Tm (There )Tj 0.0252 Tc 2.916 0 Td (was )Tj 0.0386 Tc 2.076 0 Td (oo )Tj 0.341 0.341 0.333 rg 0.0173 Tc 1.451 0 Td (significant )Tj 0.278 0.278 0.275 rg 0.0091 Tc 4.805 0 Td (difference )Tj 0.0207 Tc 4.616 0 Td (between )Tj 0.0301 Tc -19.542 -1.115 Td (them )Tj -0.0336 Tc 2.612 0 Td (in )Tj 0.341 0.341 0.333 rg 0.0398 Tc 1.218 0 Td (terms )Tj 0.278 0.278 0.275 rg 0.05 Tc 11.1292 0 0 9.9 374.29 165.85 Tm (of )Tj 0.0398 Tc 9.9 0 0 9.9 387.26 165.85 Tm (age)Tj 0.431 0.435 0.423 rg 0 Tc 1.45 0 Td (, )Tj 0.278 0.278 0.275 rg 0.025 Tc 0.741 0 Td (height )Tj 0.05 Tc 10.0265 0 0 9.9 439.1 165.85 Tm (and )Tj 0.0476 Tc 9.9 0 0 9.9 459.37 165.85 Tm (body )Tj 0.015 Tc 2.568 0 Td (weight. )Tj 0.05 Tc 10.2656 0 0 9.9 519.27 165.85 Tm (The )Tj 10.2291 0 0 9.9 308.12 154.8 Tm (FEY )Tj 0.341 0.341 0.333 rg 0 Tc 6.2 0 0 6.2 329.55 152.89 Tm (1 )Tj 0.0143 Tc 9.9 0 0 9.9 337.9 154.8 Tm (values )Tj 0.278 0.278 0.275 rg 0.0136 Tc 3.096 0 Td (differed )Tj 0.0149 Tc 3.783 0 Td (in )Tj 0.0457 Tc 1.267 0 Td (the )Tj 0.0032 Tc 1.842 0 Td (two )Tj 0.0404 Tc 2.03 0 Td (groups )Tj 0.0286 Tc 3.392 0 Td (only )Tj 0.0233 Tc 2.336 0 Td (when )Tj 0.0191 Tc -20.762 -1.066 Td (expressed )Tj 0.05 Tc 9.9203 0 0 9.9 352.22 144.25 Tm (as )Tj 0 Tc 9.9 0 0 9.9 364.7 144.25 Tm (a )Tj 0.0322 Tc 0.836 0 Td (percentage )Tj 0.05 Tc 10.5727 0 0 9.9 422.3 144.25 Tm (of )Tj 0.0336 Tc 9.9 0 0 9.9 434.42 144.25 Tm (predicted )Tj 0.013 Tc 4.311 0 Td (value. )Tj 0.341 0.341 0.333 rg 0.05 Tc 9.9653 0 0 9.9 317.67 133.21 Tm (Table )Tj 0.278 0.278 0.275 rg 0.009 Tc 9.9 0 0 9.9 346.98 133.21 Tm (2A )Tj 0.0253 Tc 1.754 0 Td (presents )Tj 0.341 0.341 0.333 rg 0.0215 Tc 3.923 0 Td (the )Tj 0.278 0.278 0.275 rg 0.0258 Tc 1.739 0 Td (individual )Tj 0.0143 Tc 4.758 0 Td (values )Tj 0.05 Tc 11.1292 0 0 9.9 498.13 133.21 Tm (of )Tj 10.2291 0 0 9.9 511.16 133.21 Tm (FEY )Tj 0.341 0.341 0.333 rg /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 532.6 130.33 Tm (1 )Tj 0.278 0.278 0.275 rg /T1_0 1 Tf 0.05 Tc 10.3398 0 0 9.9 308.05 122.16 Tm (and )Tj -0.035 Tc 9.3047 0 0 9.9 329.74 122.16 Tm (YT )Tj 0.0135 Tc 9.9 0 0 9.9 347.41 122.16 Tm (for )Tj 0.188 0.188 0.184 rg 0.0274 Tc 1.853 0 Td (non)Tj 0.341 0.341 0.333 rg 0.0309 Tc 1.635 0 Td (smokers )Tj 0.278 0.278 0.275 rg 0.0149 Tc 4.079 0 Td (in )Tj 0.0215 Tc 1.412 0 Td (the )Tj 0.0349 Tc 1.842 0 Td (three )Tj 0.0304 Tc 2.658 0 Td (experimental )Tj 0.341 0.341 0.333 rg 0.0407 Tc -17.502 -1.115 Td (conditions )Tj 0.278 0.278 0.275 rg 0.0247 Tc 5.042 0 Td (associated )Tj 0.0236 Tc 4.858 0 Td (with )Tj 0.0363 Tc 2.327 0 Td (histamine )Tj 0.05 Tc 11.1292 0 0 9.9 474.13 111.12 Tm (or )Tj 0.0283 Tc 9.9 0 0 9.9 488.14 111.12 Tm (methylcho\255)Tj 0.0233 Tc -18.188 -1.066 Td (line )Tj 0.0378 Tc 1.939 0 Td (inhalation. )Tj 0.05 Tc 10.5034 0 0 9.9 377.69 100.57 Tm (In )Tj 0.0269 Tc 9.9 0 0 9.9 391.67 100.57 Tm (response )Tj 0.0496 Tc 4.12 0 Td (to )Tj 0.0303 Tc 1.31 0 Td (histamine )Tj 0.05 Tc 11.1292 0 0 9.9 489.97 100.57 Tm (or )Tj 0.0243 Tc 9.9 0 0 9.9 503.5 100.57 Tm (methyl-)Tj ET endstream endobj 3 0 obj <>stream jP ftypjp2 jp2 jpxbjpx rreq@ --jp2hihdrcolryjp2cOQ/R \#B@HHPHHPHHPHHP((( 3߇KqPìm)u*x6B86LĤ9+o'ѷ.QB+K~ ޖ$dLݛ3Q^d!I`B7W;T=W@eEѽ(\b {^:)fqkq3 XDzvΫ?ozV}ɞӕ.ӬU pBaiD'=&dNƚ;+ ܟ3Mq(B6%qA0mW6u N?AntI/F mgʨɮ hPnM}ogfI66,DB%C%}T7zLdN7@?zmm|0=r\)= Bv0P?ȔŎoY@(PSÙL <Lr ƮfZXb_ڳt&jVox2:GĐiOتM/[rߟIZGBӇʪĘ }K1`}e>34KLjԻnwj")P6z=fNmuΦ @b50.=W?_@&KqǐgLŲP?F2ΫJJV B߆ôyz\e`Hnw0x}SΧ[9xȁg'9ǡ@ +BaDGGQc1P'?x6)lPNܥ0z~˺x~poe#EHmW,cـ_?HVUxpz90sAԧڭ[3ٷ~f$L&7pMS)b,xlLy0$P+3336,-LJ 3.ٖPHRhW!/* f+Y>ظjZQRM{y/z._W]$I$I$K[ʎ}`|(,Wv61{-s±":ǀ'kKNCH ;F+x2Xe^R\I$I$I#wPO2?b/Bq^xnbFhU%.gpmWӭ?! =g痊^匒#0MGOH=f}5h cSf#Jlau8Q %N ]$B@HHPHHPHHPHHP(((]$B@HHPHHPHHPHHP(((]$B@HHPHHPHHPHHPHHPϵ<\ij=// #Rz`z*C>\p`F\3Q #`I-h@jBV-k{S%&iմkl &rP|}øӼrtĵ{vKt?`|[ fJiy7pI=W7 Lk4*&Ví0qcXՙCq*S|lrEduoCVWKj+0|r;`U=|g$]!68),+mIG4U0{ bC)paL1U[eo7)lbۤTg1Z5`x%o}MYf= K Ma|M:HLIÀ3- 7 x|ۺ@-muEVjPUTq~yz]&3o11=Roi:j y@j9;d[(4 +;ZXB͚b.> bcme*"88k)3!]:> ѝągqFgT!* uiUV͈T< 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(of )Tj 0.255 0.255 0.251 rg 0.0408 Tc 9.9 0 0 9.9 245.66 751.44 Tm (control )Tj 0.0182 Tc -19.774 -1.066 Td (value )Tj 0.318 0.318 0.314 rg 0.0435 Tc 9.6 0 0 9.6 78.13 740.89 Tm (\(C\) )Tj 0.05 Tc 12.0791 0 0 9.9 97.78 740.89 Tm (\(\261s)Tj 0.165 0.165 0.161 rg 0 Tc 9.9 0 0 9.9 114.62 740.89 Tm (o)Tj 0.318 0.318 0.314 rg 0.586 0 Td (\) )Tj -0.027 Tc 0.975 0 Td (was: )Tj -0.0054 Tc 2.413 0 Td (32.8 )Tj -0.0043 Tc 2.376 0 Td (\(17.2\) )Tj 0.05 Tc 10.0265 0 0 9.9 207.26 740.89 Tm (and )Tj -0.0054 Tc 9.9 0 0 9.9 229.32 740.89 Tm (34.9 )Tj -0.0043 Tc 2.327 0 Td (\(18.5\) )Tj 0.0054 Tc -20.449 -1.115 Td (respectively. )Tj 0.255 0.255 0.251 rg 0.05 Tc 10.1097 0 0 9.9 108.44 729.85 Tm (For )Tj 0.318 0.318 0.314 rg 0.0215 Tc 9.9 0 0 9.9 130.06 729.85 Tm (the )Tj 0.0323 Tc 1.83 0 Td (smokers, )Tj 0.0215 Tc 4.521 0 Td (the )Tj 0.0355 Tc 1.83 0 Td (same )Tj 0.255 0.255 0.251 rg 0.05 Tc 10.377 0 0 9.9 238.46 729.85 Tm (data )Tj 0.318 0.318 0.314 rg 9.9087 0 0 9.9 263.42 729.85 Tm (are )Tj 0.0257 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(whether )Tj 0.255 0.255 0.251 rg 0.0309 Tc 3.678 0 Td (induc)Tj 0.4 0.4 0.396 rg 0.0464 Tc 2.324 0 Td (ed )Tj 0.255 0.255 0.251 rg -0.0207 Tc 1.321 0 Td (by )Tj 0.318 0.318 0.314 rg 0.0242 Tc 1.259 0 Td (histamine )Tj 0.05 Tc 10.5727 0 0 9.9 202.46 697.21 Tm (or )Tj 0.255 0.255 0.251 rg 0.019 Tc 9.9 0 0 9.9 214.06 697.21 Tm (methylcbolinc, )Tj ET BT /Suspect <>BDC 0.318 0.318 0.314 rg /T1_0 1 Tf 0.05 Tc 10.3369 0 0 9.9 49.8 686.17 Tm (30.6\261 )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf -0.0262 Tc 9.9 0 0 9.9 77.9 686.17 Tm (15.3 )Tj 0.318 0.318 0.314 rg 0.05 Tc 10.0265 0 0 9.9 105.5 686.17 Tm (and )Tj -0.035 Tc 9.8502 0 0 9.9 132.85 686.17 Tm (34.1 )Tj 0 Tc 9.9 0 0 9.9 151.67 686.17 Tm (\261 )Tj 0.255 0.255 0.251 rg -0.0262 Tc 0.985 0 Td (15.6 )Tj 0.318 0.318 0.314 rg 0.0054 Tc 2.797 0 Td (respectively. )Tj 0.026 Tc 6.296 0 Td (These )Tj 0.0327 Tc -20.463 -1.067 Td (changes )Tj 0.0171 Tc 4.227 0 Td (were )Tj 0.0215 Tc 2.811 0 Td (the )Tj 0.0355 Tc 2.024 0 Td (same )Tj -0.0336 Tc 3.012 0 Td (in )Tj 0.05 Tc 10.0136 0 0 9.9 184.33 675.61 Tm (both )Tj 0.0404 Tc 9.9 0 0 9.9 211.6 675.61 Tm (groups)Tj 0.165 0.165 0.161 rg 0 Tc 2.944 0 Td (. )Tj 0.318 0.318 0.314 rg 0.0473 Tc 1.036 0 Td (When )Tj 0.013 Tc -20.372 -1.116 Td (expressed )Tj 0.255 0.255 0.251 rg -0.0336 Tc 4.658 0 Td (in )Tj 0.318 0.318 0.314 rg 0.0288 Tc 1.368 0 Td (percent )Tj 0.05 Tc 11.1292 0 0 9.9 144.85 664.56 Tm (of )Tj 0.0215 Tc 9.9 0 0 9.9 159.38 664.56 Tm (predicted )Tj 0.0303 Tc 4.457 0 Td (value )Tj 0.05 Tc 11.3481 0 0 9.9 231.23 664.56 Tm (\(\261so\) )Tj 0.0215 Tc 9.9 0 0 9.9 263.5 664.56 Tm (the )Tj 0.255 0.255 0.251 rg 0.0239 Tc -21.624 -1.114 Td (mean )Tj ET BT /Suspect <>BDC 0.318 0.318 0.314 rg /T1_0 1 Tf 0.05 Tc 9.9856 0 0 9.9 77.24 653.53 Tm (FEV)Tj 0 Tc 6.2 0 0 6.2 98.19 651.12 Tm (1 )Tj EMC ET BT /T1_0 1 Tf -0.0233 Tc 9.9 0 0 9.9 106.55 653.53 Tm (was )Tj 0.255 0.255 0.251 rg 0.0168 Tc 2.027 0 Td (also )Tj 0.0215 Tc 2.19 0 Td (the )Tj 0.4 0.4 0.396 rg 0.05 Tc 10.0847 0 0 9.9 165.46 653.53 Tm (sa)Tj 0.255 0.255 0.251 rg 0.0451 Tc 9.9 0 0 9.9 174.7 653.53 Tm (me )Tj -0.0336 Tc 1.739 0 Td (in )Tj 0.05 Tc 9.9205 0 0 9.9 204.47 653.53 Tm (non)Tj 0.4 0.4 0.396 rg 0.0329 Tc 9.9 0 0 9.9 220.66 653.53 Tm (smoke)Tj 0.255 0.255 0.251 rg 0.0056 Tc 2.777 0 Td (rs )Tj 0.318 0.318 0.314 rg 0.05 Tc 10.0265 0 0 9.9 260.06 653.53 Tm (and )Tj 0.0389 Tc 9.9 0 0 9.9 48.82 642.48 Tm (smokers )Tj 0.05 Tc 10.0265 0 0 9.9 90.14 642.48 Tm (and )Tj 0.0425 Tc 9.9 0 0 9.9 112.22 642.48 Tm (after )Tj 0.0412 Tc 2.678 0 Td (both )Tj 0.0301 Tc 2.618 0 Td (bronchoconstrictors: )Tj -0.0095 Tc 9.491 0 Td (72.9 )Tj 0.0054 Tc -21.189 -1.067 Td (\(22.8\) )Tj 0.05 Tc 10.0265 0 0 9.9 78.62 631.92 Tm (and )Tj 0.0067 Tc 9.9 0 0 9.9 100.2 631.92 Tm (63.7 )Tj 0.255 0.255 0.251 rg 0.0317 Tc 2.279 0 Td (\(I )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.8963 0 0 9.9 132.62 631.92 Tm (1.5\) )Tj EMC ET BT /T1_0 1 Tf 0.011 Tc 9.9 0 0 9.9 152.63 631.92 Tm (respectively )Tj 0.318 0.318 0.314 rg 0.0304 Tc 5.518 0 Td (after )Tj 0.0261 Tc 2.53 0 Td (histamine, )Tj -0.0095 Tc -18.484 -1.114 Td (69.4 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0267 Tc 9.9 0 0 9.9 70.4303 620.8914 Tm (\(23)Tj 0.165 0.165 0.161 rg 0 Tc 1.348 0 Td (.)Tj 0.318 0.318 0.314 rg -0.035 Tc 9.8919 0 0 9.9 86.3 620.89 Tm (0\) )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.0265 0 0 9.9 98.3 620.89 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0095 Tc 9.9 0 0 9.9 117.96 620.89 Tm (60.5 )Tj EMC ET BT /T1_0 1 Tf 0.0054 Tc 9.9 0 0 9.9 139.0767 620.89 Tm (\(16.2\) )Tj 0.255 0.255 0.251 rg 0.011 Tc 2.872 0 Td (respectively )Tj 0.318 0.318 0.314 rg 0.0425 Tc 5.324 0 Td (after )Tj 0.0162 Tc 2.384 0 Td (methyl\255)Tj 0.0181 Tc -19.693 -1.115 Td (choline. )Tj 0.255 0.255 0.251 rg 0.05 Tc 10.4358 0 0 9.9 85.87 609.85 Tm (For )Tj 0.318 0.318 0.314 rg 0.0272 Tc 9.9 0 0 9.9 104.53 609.85 Tm (each )Tj 0.0343 Tc 2.28 0 Td (corresponding )Tj 0.026 Tc 6.447 0 Td (experimental )Tj 0.0267 Tc 5.868 0 Td (condi\255)Tj 0.0161 Tc -20.162 -1.116 Td (tion )Tj 0.0457 Tc 2.036 0 Td (the )Tj 0.0239 Tc 1.697 0 Td (mean )Tj 0.255 0.255 0.251 rg -0.035 Tc 9.2996 0 0 9.9 112.78 598.8 Tm (VT )Tj 0.318 0.318 0.314 rg 0.001 Tc 9.9 0 0 9.9 128.63 598.8 Tm (was )Tj 0.0215 Tc 1.987 0 Td (the )Tj 0.0355 Tc 1.636 0 Td (same )Tj 0.0149 Tc 2.527 0 Td (in )Tj 0.05 Tc 10.0136 0 0 9.9 201.61 598.8 Tm (both )Tj 0.255 0.255 0.251 rg 0.0346 Tc 9.9 0 0 9.9 224.63 598.8 Tm (nonsmokers )Tj 0.318 0.318 0.314 rg 0.05 Tc 10.0265 0 0 9.9 48.86 588.24 Tm (and )Tj 0.4 0.4 0.396 rg 0 Tc 9.9 0 0 9.9 68.02 588.24 Tm (s)Tj 0.255 0.255 0.251 rg 0.0263 Tc 0.4 0 Td (mokers. )Tj 0.318 0.318 0.314 rg 0.05 Tc 9.9506 0 0 9.9 109.37 588.24 Tm (In )Tj 0.255 0.255 0.251 rg 0.0278 Tc 9.9 0 0 9.9 122.41 588.24 Tm (bo)Tj 0.4 0.4 0.396 rg 0.0496 Tc 1.064 0 Td (th )Tj 0.318 0.318 0.314 rg 0.0404 Tc 1.158 0 Td (groups )Tj 0.0349 Tc 3.303 0 Td (there )Tj 0.001 Tc 2.474 0 Td (was )Tj 0.255 0.255 0.251 rg 0.05 Tc 10.0889 0 0 9.9 220.79 588.24 Tm (no )Tj 0.318 0.318 0.314 rg 0.0091 Tc 9.9 0 0 9.9 234.63 588.24 Tm (difference )Tj 0.0126 Tc -18.705 -1.114 Td (between )Tj 0.0188 Tc 3.976 0 Td (baseline )Tj -0.002 Tc 3.914 0 Td (\(B\) )Tj 0.05 Tc 10.0265 0 0 9.9 146.3 577.21 Tm (and )Tj 0.0268 Tc 9.9 0 0 9.9 167.9 577.21 Tm (C, )Tj 0.0209 Tc 1.512 0 Td (whereas )Tj 0 Tc 3.967 0 Td (a )Tj 0.0221 Tc 1.014 0 Td (significant )Tj 0.165 0.165 0.161 rg 0.0141 Tc -18.515 -1.115 Td (incre)Tj 0.318 0.318 0.314 rg 0.0226 Tc 2.083 0 Td (ase )Tj 0.0252 Tc 1.755 0 Td (was )Tj 0.0208 Tc 2.076 0 Td (observed )Tj 0.0149 Tc 4.266 0 Td (following )Tj 0.0181 Tc 4.568 0 Td (histamine )Tj 0.05 Tc 10.0265 0 0 9.9 239.42 566.17 Tm (and )Tj 0.0257 Tc 9.9 0 0 9.9 259.66 566.17 Tm (me\255)Tj 0.0261 Tc -21.285 -1.067 Td (thylcho)Tj 0.165 0.165 0.161 rg 0 Tc 3.194 0 Td (l)Tj 0.318 0.318 0.314 rg 0.0284 Tc 0.242 0 Td (ine )Tj 0.033 Tc 1.648 0 Td (inhalation. )Tj 0.255 0.255 0.251 rg 0.05 Tc 9.9653 0 0 9.9 57.99 544.56 Tm (Table )Tj 0.318 0.318 0.314 rg 0 Tc 9.9 0 0 9.9 87.72 544.56 Tm (3 )Tj 0.0098 Tc 0.877 0 Td (gives )Tj 0.0215 Tc 2.624 0 Td (the )Tj 0.0239 Tc 1.794 0 Td (mean )Tj 0.0046 Tc 2.812 0 Td (values )Tj 0.029 Tc 3.046 0 Td (characterizing )Tj 0.0215 Tc 6.554 0 Td (the )Tj 0.255 0.255 0.251 rg 0.0219 Tc -21.624 -1.114 Td (timing )Tj 0.05 Tc 10.5727 0 0 9.9 83.42 533.53 Tm (of )Tj 0.318 0.318 0.314 rg 0.0286 Tc 9.9 0 0 9.9 100.31 533.53 Tm (respiration )Tj 0.0377 Tc 5.372 0 Td (for )Tj 0.255 0.255 0.251 rg 0.0412 Tc 2.048 0 Td (both )Tj 0.0346 Tc 2.762 0 Td (nonsmokers )Tj 0.318 0.318 0.314 rg 0.05 Tc 10.0265 0 0 9.9 259.58 533.53 Tm (and )Tj 0.0254 Tc 9.9 0 0 9.9 48.34 522.48 Tm (smokers. )Tj 0.255 0.255 0.251 rg 0.0112 Tc 4.519 0 Td (Between )Tj 0.318 0.318 0.314 rg 0.0215 Tc 4.317 0 Td (the )Tj 0.0274 Tc 1.988 0 Td (two )Tj 0.0404 Tc 2.273 0 Td (groups )Tj 0.0349 Tc 3.642 0 Td (there )Tj 0.001 Tc 2.862 0 Td (was )Tj 0.05 Tc 10.0889 0 0 9.9 264.95 522.48 Tm (no )Tj 0.0173 Tc 9.9 0 0 9.9 48.34 511.44 Tm (significant )Tj 0.0091 Tc 4.708 0 Td (difference )Tj -0.0336 Tc 4.51 0 Td (in )Tj 0.0143 Tc 1.17 0 Td (values )Tj 0.0379 Tc 2.998 0 Td (obtained )Tj 0.255 0.255 0.251 rg 0.0149 Tc 4.123 0 Td (in )Tj 0 Tc 1.119 0 Td (B )Tj 0.318 0.318 0.314 rg 0.05 Tc 11.1292 0 0 9.9 242.77 511.44 Tm (or )Tj 0 Tc 9.9 0 0 9.9 255.74 511.44 Tm (C )Tj 0.05 Tc 10.5727 0 0 9.9 266.3 511.44 Tm (or )Tj 0.0422 Tc 9.9 0 0 9.9 48.39 500.89 Tm (during )Tj 0.0362 Tc 3.646 0 Td (bronchospasm. )Tj 0.038 Tc 7.269 0 Td (Within )Tj 0.0272 Tc 3.774 0 Td (each )Tj 0.05 Tc 9.9115 0 0 9.9 221.2 500.89 Tm (group )Tj 0.0209 Tc 9.9 0 0 9.9 254.38 500.89 Tm (these )Tj 0.0143 Tc -20.8 -1.116 Td (values )Tj 0.0171 Tc 2.862 0 Td (were )Tj 0.0215 Tc 2.278 0 Td (the )Tj 0.0355 Tc 1.491 0 Td (same )Tj 0.0149 Tc 2.43 0 Td (in )Tj 0.255 0.255 0.251 rg 0.05 Tc 10.7268 0 0 9.9 148.75 489.84 Tm (Band )Tj 0.318 0.318 0.314 rg 0 Tc 9.9 0 0 9.9 175.58 489.84 Tm (C )Tj 0.05 Tc 10.0265 0 0 9.9 184.7 489.84 Tm (and )Tj 0.0448 Tc 9.9 0 0 9.9 202.47 489.84 Tm (did )Tj 0.0419 Tc 1.705 0 Td (not )Tj 0.0394 Tc 1.591 0 Td (change )Tj -0.0336 Tc 3.299 0 Td (in )Tj 0.02 Tc -22.151 -1.114 Td (response )Tj 0.0496 Tc 4.217 0 Td (to )Tj 0.0303 Tc 1.407 0 Td (histamine )Tj 0.05 Tc 10.5727 0 0 9.9 150.14 478.81 Tm (or )Tj 0.0252 Tc 9.9 0 0 9.9 164.62 478.81 Tm (methylcholine )Tj 0.033 Tc 6.539 0 Td (inhalation. )Tj 0.255 0.255 0.251 rg 0.0432 Tc -18.321 -1.116 Td (Although )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0431 Tc 9.9 0 0 9.9 91.5976 467.7616 Tm (Tr )Tj EMC ET BT /T1_0 1 Tf 0.032 Tc 9.9 0 0 9.9 104.5567 467.7616 Tm (looks )Tj 0.318 0.318 0.314 rg 0.0344 Tc 2.612 0 Td (somewhat )Tj 0.255 0.255 0.251 rg 0.0355 Tc 4.661 0 Td (longer )Tj 0.165 0.165 0.161 rg 0.0149 Tc 3.055 0 Td (in )Tj 0.318 0.318 0.314 rg 0.0309 Tc 1.109 0 Td (smokers )Tj 0.255 0.255 0.251 rg 0.0416 Tc 3.939 0 Td (than )Tj 0.318 0.318 0.314 rg 0.0149 Tc -21.048 -1.115 Td (in )Tj 0.0353 Tc 1.122 0 Td (nonsmokers, )Tj 0.0215 Tc 5.866 0 Td (the )Tj 0.0091 Tc 1.641 0 Td (difference )Tj -0.0195 Tc 4.462 0 Td (is )Tj 0.05 Tc 10.1333 0 0 9.9 188.15 456.72 Tm (not )Tj 0.0106 Tc 9.9 0 0 9.9 205.78 456.72 Tm (significant. )Tj 0.255 0.255 0.251 rg 0.05 Tc 9.9402 0 0 9.9 58.04 446.16 Tm (Mean )Tj 0.318 0.318 0.314 rg 0.0143 Tc 9.9 0 0 9.9 86.86 446.16 Tm (values )Tj 0.0377 Tc 3.045 0 Td (for )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.9276 0 0 12.3 133.9 446.16 Tm (VE )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 11.3481 0 0 9.9 149.63 446.16 Tm (\(\261so\) )Tj 10.7518 0 0 9.9 179.89 446.16 Tm (at )Tj 0.255 0.255 0.251 rg 0 Tc 9.9 0 0 9.9 193.4 446.16 Tm (B )Tj 0.318 0.318 0.314 rg 0.0249 Tc 1.023 0 Td (before )Tj 0.0303 Tc 3.101 0 Td (histamine )Tj 0.05 Tc 10.0265 0 0 9.9 47.9 435.12 Tm (and )Tj 0.0252 Tc 9.9 0 0 9.9 69.58 435.12 Tm (mcthylcholine )Tj 0.0009 Tc 6.595 0 Td (were )Tj 0.255 0.255 0.251 rg 0.0031 Tc 2.57 0 Td (respectively: )Tj -0.0095 Tc 5.807 0 Td (6.93 )Tj 0.318 0.318 0.314 rg 0.05 Tc 12.6303 0 0 9.9 240.81 435.12 Tm (\(\261 )Tj 0.255 0.255 0.251 rg -0.0059 Tc 9.9 0 0 9.9 255.02 435.12 Tm (1.25\) )Tj 0.318 0.318 0.314 rg 0.0355 Tc -20.921 -1.114 Td (and )Tj -0.0095 Tc 1.986 0 Td (6.89 )Tj 0.05 Tc 12.6303 0 0 9.9 88.65 424.09 Tm (\(\261 )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf -0.0181 Tc 9.9 0 0 9.9 103.34 424.09 Tm (1.25\) )Tj EMC /Suspect <>BDC 0.318 0.318 0.314 rg /T1_2 1 Tf 0 Tc 9.4 0 0 9.4 127.04 424.09 Tm (I )Tj EMC ET BT /T1_0 1 Tf 0.0149 Tc 9.9 0 0 9.9 132.88 424.09 Tm (in )Tj 0.04 Tc 1.219 0 Td (nonsmokers )Tj 0.05 Tc 10.0265 0 0 9.9 200.06 424.09 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0067 Tc 9.9 0 0 9.9 219.73 424.09 Tm (7.06 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 12.6303 0 0 9.9 241.29 424.09 Tm (\(\261 )Tj -0.0059 Tc 9.9 0 0 9.9 255.02 424.09 Tm (1.43\) )Tj 0.05 Tc 10.0265 0 0 9.9 47.9 413.05 Tm (and )Tj -0.0095 Tc 9.9 0 0 9.9 66.61 413.05 Tm (7.13 )Tj /T1_1 1 Tf 0.05 Tc 13.3053 0 0 9.7 86.64 413.05 Tm (\(\261 )Tj /T1_0 1 Tf -0.0181 Tc 9.9 0 0 9.9 101.42 413.05 Tm (1.41\) )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0 Tc 10.1 0 0 10.1 124.15 413.05 Tm (I )Tj EMC ET BT /T1_0 1 Tf -0.0336 Tc 9.9 0 0 9.9 130 413.05 Tm (in )Tj 0.0323 Tc 1.061 0 Td (smokers. )Tj 0.255 0.255 0.251 rg 0.026 Tc 4.127 0 Td (These )Tj 0.318 0.318 0.314 rg 0.0143 Tc 2.818 0 Td (values )Tj 0.255 0.255 0.251 rg 0.0009 Tc 2.959 0 Td (were )Tj 0.318 0.318 0.314 rg 0.05 Tc 10.1333 0 0 9.9 261.11 413.05 Tm (not )Tj 0.0197 Tc 9.9 0 0 9.9 47.43 402 Tm (different )Tj 0.0247 Tc 3.974 0 Td (from )Tj 0.0272 Tc 2.376 0 Td (each )Tj 0.05 Tc 10.1049 0 0 9.9 132.86 402 Tm (other )Tj 10.0265 0 0 9.9 158.78 402 Tm (and )Tj 0.0205 Tc 9.9 0 0 9.9 177.99 402 Tm (did )Tj 0.255 0.255 0.251 rg 0.0419 Tc 1.754 0 Td (not )Tj 0.318 0.318 0.314 rg 0.0138 Tc 1.689 0 Td (differ )Tj 0.255 0.255 0.251 rg 0.0086 Tc 2.665 0 Td (from )Tj 0.318 0.318 0.314 rg 0.0457 Tc 2.385 0 Td (the )Tj 0.0383 Tc -21.681 -1.067 Td (corresponding )Tj 0.0408 Tc 6.448 0 Td (control )Tj 0.05 Tc 10.1109 0 0 9.9 144.86 391.44 Tm (data )Tj 0.0245 Tc 9.9 0 0 9.9 166.55 391.44 Tm (represented )Tj 0.0149 Tc 5.181 0 Td (in )Tj -0.0059 Tc 1.112 0 Td (figure )Tj 0.0135 Tc 2.816 0 Td (I. )Tj 0.05 Tc 9.9506 0 0 9.9 265.85 391.44 Tm (In )Tj 0.0346 Tc 9.9 0 0 9.9 47.99 380.41 Tm (nonsmokers )Tj 0.0401 Tc 5.623 0 Td (mean )Tj 0.255 0.255 0.251 rg -0.0182 Tc 2.715 0 Td (VT/Tr )Tj 0.318 0.318 0.314 rg 0.05 Tc 11.3481 0 0 9.9 160.19 380.41 Tm (\(\261so\) )Tj 0.255 0.255 0.251 rg -0.0336 Tc 9.9 0 0 9.9 190.96 380.41 Tm (in )Tj 0 Tc 1.265 0 Td (B )Tj 0.318 0.318 0.314 rg 0.0252 Tc 1.07 0 Td (was )Tj -0.0285 Tc 2.074 0 Td (377 )Tj -0.0034 Tc 1.891 0 Td (\(146\) )Tj 0.0249 Tc -20.738 -1.115 Td (before )Tj 0.255 0.255 0.251 rg 0.0303 Tc 3.489 0 Td (histamine )Tj 0.318 0.318 0.314 rg 0.05 Tc 10.3398 0 0 9.9 131.89 369.37 Tm (and )Tj -0.035 Tc 9.8266 0 0 9.9 156.37 369.37 Tm (35)Tj 0.165 0.165 0.161 rg 0 Tc 9.9 0 0 9.9 167.18 369.37 Tm (1 )Tj 0.318 0.318 0.314 rg -0.0034 Tc 1.234 0 Td (\(113\) )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf 0.05 Tc 10.2891 0 0 9.9 209.26 369.37 Tm (ml\267)Tj 0.4 0.4 0.396 rg 0 Tc 9.9 0 0 9.9 224.98 369.37 Tm (s)Tj 0.584 0.584 0.58 rg 0.535 0 Td (-)Tj 0.318 0.318 0.314 rg 6.2 0 0 6.2 236.43 373.21 Tm (1 )Tj EMC ET BT /T1_0 1 Tf 0.0152 Tc 9.9 0 0 9.9 248.65 369.37 Tm (before )Tj 0.0249 Tc -20.318 -1.115 Td (methylcho)Tj 0.165 0.165 0.161 rg 0 Tc 4.503 0 Td (l)Tj 0.318 0.318 0.314 rg 0.0002 Tc 0.291 0 Td (ine. )Tj 0.165 0.165 0.161 rg -0.0081 Tc 1.99 0 Td (Jn )Tj 0.4 0.4 0.396 rg 0.0281 Tc 1.398 0 Td (smo)Tj 0.255 0.255 0.251 rg 0.0412 Tc 1.758 0 Td (ker)Tj 0.4 0.4 0.396 rg 0 Tc 1.394 0 Td (s )Tj 0.318 0.318 0.314 rg -0.035 Tc 9.5456 0 0 9.9 168.4 358.33 Tm (it )Tj 0.0252 Tc 9.9 0 0 9.9 178.55 358.33 Tm (was )Tj -0.0043 Tc 2.074 0 Td (336 )Tj 0.0005 Tc 1.939 0 Td (\(82\) )Tj 0.0355 Tc 2.184 0 Td (and )Tj -0.0043 Tc 2.034 0 Td (343 )Tj 0.0005 Tc -21.479 -1.068 Td (\(75\) )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf 0.05 Tc 9.9461 0 0 9.9 67.18 347.76 Tm (ml\267 )Tj EMC ET BT 0.318 0.318 0.314 rg /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 82.42 347.76 Tm [(s )55(-)]TJ 0.459 0.459 0.455 rg 6.2 0 0 6.2 93.87 351.12 Tm (1 )Tj 0.318 0.318 0.314 rg 0.0054 Tc 9.9 0 0 9.9 101.27 347.76 Tm (respectively. )Tj 0.255 0.255 0.251 rg 0.0252 Tc 5.575 0 Td (Again, )Tj 0.0484 Tc 3.201 0 Td (none )Tj 0.318 0.318 0.314 rg 0.05 Tc 11.1292 0 0 9.9 212.05 347.76 Tm (of )Tj 0.0088 Tc 9.9 0 0 9.9 224.62 347.76 Tm (these )Tj 0.0143 Tc 2.424 0 Td (values )Tj 0.0067 Tc -20.371 -1.115 Td (differed )Tj 0.0409 Tc 4.071 0 Td (from )Tj 0.0272 Tc 2.909 0 Td (each )Tj 0.05 Tc 10.1049 0 0 9.9 143.42 336.72 Tm (other )Tj 0.0355 Tc 9.9 0 0 9.9 174.14 336.72 Tm (and )Tj 0.0215 Tc 2.432 0 Td (the )Tj 0.05 Tc 10.1109 0 0 9.9 218.78 336.72 Tm (data )Tj 0.255 0.255 0.251 rg 0.0149 Tc 9.9 0 0 9.9 245.68 336.72 Tm (in )Tj 0.318 0.318 0.314 rg 0.0457 Tc 1.655 0 Td (the )Tj 0.0383 Tc -21.729 -1.114 Td (corresponding )Tj 0.0408 Tc 6.497 0 Td (control )Tj 0.0359 Tc 3.442 0 Td (conditions, )Tj 0.05 Tc 9.9203 0 0 9.9 196.22 325.69 Tm (as )Tj 0.0324 Tc 9.9 0 0 9.9 208.18 325.69 Tm (shown )Tj 0.255 0.255 0.251 rg 0.0149 Tc 3.158 0 Td (in )Tj 0.318 0.318 0.314 rg -0.0059 Tc 1.161 0 Td (figure )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 48.4138 314.6515 Tm (I)Tj 0.4 0.4 0.396 rg 0.38 0 Td (, )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf 0.0171 Tc 9.9 0 0 9.9 59.0365 314.6515 Tm (were )Tj 0.318 0.318 0.314 rg 0.0233 Tc 2.46 0 Td (statistically )Tj 0.0215 Tc 5.394 0 Td (the )Tj 0.0248 Tc 1.685 0 Td (same. )Tj 0.05 Tc 9.9723 0 0 9.9 182.31 314.65 Tm (The )Tj 0.0401 Tc 9.9 0 0 9.9 203.5 314.65 Tm (mean )Tj 0.0143 Tc 2.812 0 Td (values )Tj 0.0377 Tc 3.142 0 Td (for )Tj 0.05 Tc 10.2291 0 0 9.9 47 303.61 Tm (FEV )Tj 0.4 0.4 0.396 rg /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 67.48 301.21 Tm (1 )Tj 0.318 0.318 0.314 rg /T1_0 1 Tf 0.0355 Tc 9.9 0 0 9.9 74.3 303.61 Tm (and )Tj 0.0215 Tc 1.899 0 Td (the )Tj 0.0422 Tc 1.556 0 Td (parameters )Tj 0.0272 Tc 5.039 0 Td (representing )Tj 0.0457 Tc 5.526 0 Td (the )Tj 0.0285 Tc 1.6 0 Td (ventilatory )Tj 0.255 0.255 0.251 rg 0.02 Tc -18.326 -1.116 Td (response )Tj 0.0493 Tc 4.074 0 Td (under )Tj 0.318 0.318 0.314 rg 0.0408 Tc 2.85 0 Td (control )Tj 0.0407 Tc 3.491 0 Td (conditions )Tj 0.05 Tc 10.3398 0 0 9.9 199.09 292.56 Tm (and )Tj 9.9334 0 0 9.9 219.27 292.56 Tm (during )Tj 0.0427 Tc 9.9 0 0 9.9 251.53 292.56 Tm (bron\255)Tj 0.0355 Tc -20.666 -1.114 Td (chospasm )Tj 0.05 Tc 9.9087 0 0 9.9 93.98 281.53 Tm (are )Tj 0.0324 Tc 9.9 0 0 9.9 112.18 281.53 Tm (shown )Tj -0.0336 Tc 3.303 0 Td (in )Tj 0.0038 Tc 1.306 0 Td (figure )Tj 0.255 0.255 0.251 rg -0.035 Tc 3.107 0 Td (I. )Tj 0.05 Tc 9.9506 0 0 9.9 199.61 281.53 Tm (In )Tj 0.0269 Tc 9.9 0 0 9.9 214.55 281.53 Tm (response )Tj 0.318 0.318 0.314 rg 0.0496 Tc 4.217 0 Td (to )Tj 0 Tc 1.349 0 Td (a )Tj 0.165 0.165 0.161 rg /T1_1 1 Tf 0.012 Tc 8.9 0 0 8.9 47.94 240.73 Tm (Table )Tj 0.255 0.255 0.251 rg 0.05 Tc 10.5911 0 0 8.9 73.58 240.73 Tm (1.-)Tj 0.0113 Tc 8.9 0 0 8.9 89.15 240.73 Tm (Characteristics )Tj 0.05 Tc 8.91 0 0 8.9 151.6 240.73 Tm (of )Tj 0.0373 Tc 8.9 0 0 8.9 161.72 240.73 Tm (the )Tj 0.0056 Tc 1.721 0 Td (studied )Tj 0.0096 Tc 3.603 0 Td (populations )Tj 0.318 0.318 0.314 rg 0.0061 Tc 5.502 0 Td (\(\261so\) )Tj 0 Tc 8.3 0 0 8.3 47.84 197.05 Tm (n )Tj /T1_0 1 Tf 0.05 Tc 9.2713 0 0 8.8 47.98 174.97 Tm (Ageyr )Tj 0.255 0.255 0.251 rg 0.0242 Tc 8.8 0 0 8.8 47.49 163.93 Tm (Weight )Tj 0.0373 Tc 3.328 0 Td (kg )Tj 0.0257 Tc -3.275 -1.255 Td (Height )Tj 0.318 0.318 0.314 rg 0.05 Tc 9.2142 0 0 8.8 74.3 152.89 Tm (em )Tj 0.255 0.255 0.251 rg -0.026 Tc 9.5 0 0 9.5 47.48 141.85 Tm (FEV)Tj 0 Tc 6.2 0 0 6.2 65.07 138.49 Tm (1)Tj 9.5 0 0 9.5 70.48 141.85 Tm (l )Tj -0.035 Tc 9.0624 0 0 9.5 47.96 130.33 Tm (FEV)Tj 0 Tc 6.2 0 0 6.2 65.07 126.96 Tm (1 )Tj 0.318 0.318 0.314 rg 0.05 Tc 9.4682 0 0 9.4 69.99 130.33 Tm (%pred )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0223 Tc 8.8 0 0 8.8 47.36 117.84 Tm (Smoking )Tj EMC ET BT /T1_0 1 Tf 0.0289 Tc 8.8 0 0 8.8 82.5512 117.84 Tm (history )Tj 0.255 0.255 0.251 rg 0.0242 Tc 3.166 0 Td (packs/yr )Tj /T1_1 1 Tf 0 Tc 12.9 0 0 12.9 47.4 95.76 Tm (* )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0065 Tc 8.8 0 0 8.8 54.25 95.76 Tm (p<0.05 )Tj EMC ET BT 0.318 0.318 0.314 rg /T1_0 1 Tf 0.0204 Tc 8.8 0 0 8.8 157.4828 218.652 Tm (Nonsmokers )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0 Tc 9 0 0 9 175.57 196.57 Tm (& )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.0108 Tc 8.8 0 0 8.8 162.14 174.49 Tm (33.5 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.3936 0 0 8.8 179.99 174.49 Tm (\2613.5 )Tj 8.8942 0 0 8.8 161.67 163.44 Tm (75)Tj 0.165 0.165 0.161 rg 0 Tc 8.8 0 0 8.8 171.18 163.44 Tm (.)Tj 0.318 0.318 0.314 rg 0.227 0 Td (9 )Tj /T1_1 1 Tf 9.7 0 0 9.7 179.89 163.44 Tm (\261 )Tj /T1_0 1 Tf 0.0198 Tc 8.8 0 0 8.8 187.53 163.44 Tm (8.2 )Tj 0.0144 Tc -3.399 -1.253 Td (181.6 )Tj 0 Tc 2.542 0 Td (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0198 Tc 8.8 0 0 8.8 187.53 152.4136 Tm (8.0 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.4736 0 0 8.8 161.72 141.85 Tm (4.94\261 )Tj 0.255 0.255 0.251 rg 0.0041 Tc 8.8 0 0 8.8 187.86 141.85 Tm (1.43 )Tj ET BT /Suspect <>BDC 0.318 0.318 0.314 rg /T1_0 1 Tf 0.05 Tc 9.1918 0 0 8.8 157.6 129.85 Tm (110.3\261 )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf -0.0141 Tc 8.8 0 0 8.8 187.86 129.85 Tm (14.1 )Tj 0.0137 Tc 6.125 10.091 Td (Smokers )Tj 0.318 0.318 0.314 rg 0 Tc 0.499 -2.509 Td (7 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0108 Tc 8.8 0 0 8.8 234.6232 174.4924 Tm (30.7 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 252.4696 174.4924 Tm (\261 )Tj 0.0108 Tc 0.862 0 Td (3.35 )Tj 0.255 0.255 0.251 rg 0.05 Tc 9.3152 0 0 8.8 234.6 163.44 Tm (67.6\261 )Tj ET BT /Suspect <>BDC 0.318 0.318 0.314 rg /T1_0 1 Tf 0.0471 Tc 8.8 0 0 8.8 260.01 163.44 Tm (8.0 )Tj EMC ET BT /T1_0 1 Tf -0.0128 Tc 8.8 0 0 8.8 230.5828 152.4136 Tm (177.1)Tj 0.459 0.459 0.455 rg 0 Tc 2.487 0 Td (\261)Tj 0.318 0.318 0.314 rg 0.0207 Tc 0.862 0 Td (3.9 )Tj 0.05 Tc 9.3617 0 0 8.8 234.61 141.37 Tm (3.82\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0057 Tc 8.8 0 0 8.8 260.07 141.37 Tm (0.69 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.3163 0 0 8.8 234.61 129.85 Tm (92.4\261 )Tj 0.0223 Tc 8.8 0 0 8.8 259.86 129.85 Tm (13.7)Tj 0.165 0.165 0.161 rg 0 Tc 1.814 0 Td (* )Tj ET BT /Suspect <>BDC 0.318 0.318 0.314 rg /T1_0 1 Tf 0.0041 Tc 8.8 0 0 8.8 234.9032 117.3628 Tm (10.8 )Tj EMC ET BT 0.459 0.459 0.455 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 252.4768 117.3628 Tm (\261 )Tj 0.318 0.318 0.314 rg -0.0155 Tc 0.868 0 Td (2.1 )Tj 0.0124 Tc 9.9 0 0 9.9 300.34 751.92 Tm (significant )Tj 0.0298 Tc 5.047 0 Td (decrease )Tj 0.0149 Tc 4.316 0 Td (in )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf 0.05 Tc 9.9856 0 0 9.9 408.44 751.92 Tm (FEY )Tj EMC ET BT 0.4 0.4 0.396 rg /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 428.44 749.53 Tm (1 )Tj 0.255 0.255 0.251 rg /T1_0 1 Tf -0.0336 Tc 9.9 0 0 9.9 440.08 751.92 Tm (in )Tj 0.318 0.318 0.314 rg 0.0457 Tc 1.558 0 Td (the )Tj 0.0274 Tc 2.085 0 Td (two )Tj 0.05 Tc 9.901 0 0 9.9 498.64 751.92 Tm (groups )Tj 0.0266 Tc 9.9 0 0 9.9 300.34 740.89 Tm (studied, )Tj 0.0228 Tc 3.939 0 Td (there )Tj 0.001 Tc 2.668 0 Td (was )Tj 0 Tc 2.124 0 Td (a )Tj 0.0188 Tc 1.063 0 Td (similar )Tj 0.0173 Tc 3.442 0 Td (significant )Tj 0.0268 Tc 4.952 0 Td (increase )Tj 0.0149 Tc 3.976 0 Td (in )Tj -0.035 Tc 9.2996 0 0 9.9 300.46 729.85 Tm (VT)Tj 0.459 0.459 0.455 rg 0 Tc 9.9 0 0 9.9 312.48 729.85 Tm (/)Tj 0.318 0.318 0.314 rg -0.0053 Tc 0.283 0 Td (TI )Tj 0.05 Tc 10.0265 0 0 9.9 333.02 729.85 Tm (and )Tj 0.0149 Tc 9.9 0 0 9.9 357.04 729.85 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.928 0 0 12.3 372.94 729.85 Tm (VE. )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf 0.05 Tc 9.9723 0 0 9.9 394.47 729.85 Tm (The )Tj 0.318 0.318 0.314 rg 0.0338 Tc 9.9 0 0 9.9 418.94 729.85 Tm (average )Tj 0.0373 Tc 4.117 0 Td (spirograms )Tj 0.0135 Tc 5.676 0 Td (for )Tj 0.0389 Tc -21.821 -1.067 Td (smokers )Tj 0.05 Tc 10.0265 0 0 9.9 340.22 719.29 Tm (and )Tj 0.255 0.255 0.251 rg 0.0274 Tc 9.9 0 0 9.9 361.43 719.29 Tm (non)Tj 0.4 0.4 0.396 rg 0.05 Tc 9.9268 0 0 9.9 377.62 719.29 Tm (smo)Tj 0.255 0.255 0.251 rg 0.011 Tc 9.9 0 0 9.9 395.5 719.29 Tm (kers )Tj 0.318 0.318 0.314 rg -0.0336 Tc 2.273 0 Td (in )Tj 0.255 0.255 0.251 rg 0.0269 Tc 1.316 0 Td (response )Tj 0.318 0.318 0.314 rg 0.05 Tc 10.4772 0 0 9.9 472.77 719.29 Tm (to )Tj 0.0363 Tc 9.9 0 0 9.9 486.71 719.29 Tm (histamine )Tj 0.0355 Tc -18.821 -1.116 Td (and )Tj 0.0212 Tc 2.19 0 Td (methylcholine)Tj 0.165 0.165 0.161 rg 0 Tc 6.002 0 Td (-)Tj 0.318 0.318 0.314 rg 0.025 Tc 0.343 0 Td (induced )Tj 0.255 0.255 0.251 rg 0.0386 Tc 3.985 0 Td (bronchospa)Tj 0.4 0.4 0.396 rg 0 Tc 5.027 0 Td (s)Tj 0.255 0.255 0.251 rg 0.4 0 Td (m )Tj 0.318 0.318 0.314 rg 0.05 Tc 9.9087 0 0 9.9 491.9 708.24 Tm (are )Tj 0.0162 Tc 9.9 0 0 9.9 511.22 708.24 Tm (pre\255)Tj 0.028 Tc -21.35 -1.114 Td (sented )Tj -0.0336 Tc 3.352 0 Td (in )Tj -0.0059 Tc 1.452 0 Td (figure )Tj -0.0038 Tc 3.011 0 Td (2. )Tj 0.05 Tc 10.1883 0 0 9.9 391.25 697.21 Tm (No )Tj 0.0091 Tc 9.9 0 0 9.9 410.31 697.21 Tm (difference )Tj 0.05 Tc 10.0003 0 0 9.9 457.34 697.21 Tm (could )Tj 0.0363 Tc 9.9 0 0 9.9 488.17 697.21 Tm (be )Tj 0.0398 Tc 1.598 0 Td (noted )Tj 0.255 0.255 0.251 rg 0.0126 Tc -20.556 -1.067 Td (between )Tj 0.318 0.318 0.314 rg 0.0389 Tc 3.67 0 Td (smokers )Tj 0.05 Tc 10.0265 0 0 9.9 374.3 686.65 Tm (and )Tj 0.0346 Tc 9.9 0 0 9.9 393.11 686.65 Tm (nonsmokers )Tj -0.0336 Tc 5.423 0 Td (in )Tj 0.0401 Tc 1.073 0 Td (their )Tj 0.255 0.255 0.251 rg 0.0269 Tc 2.28 0 Td (response )Tj 0.0496 Tc 3.975 0 Td (to )Tj 0.318 0.318 0.314 rg 0.0412 Tc -22.106 -1.115 Td (both )Tj 0.031 Tc 2.269 0 Td (drugs. )Tj 0.0266 Tc -1.276 -1.116 Td ([n )Tj 0.0304 Tc 1.284 0 Td (nonsmokers, )Tj 0.0425 Tc 5.809 0 Td (after )Tj 0.0242 Tc 2.385 0 Td (histamine )Tj 0.05 Tc 10.0265 0 0 9.9 448.22 664.56 Tm (and )Tj 0.0333 Tc 9.9 0 0 9.9 467.5 664.56 Tm (methylcholine )Tj 0.0378 Tc -16.927 -1.114 Td (inhalation, )Tj 0.0215 Tc 5.485 0 Td (the )Tj 0.0201 Tc 2.077 0 Td (cha)Tj 0.165 0.165 0.161 rg 0 Tc 1.512 0 Td (n)Tj 0.318 0.318 0.314 rg -0.0041 Tc 0.526 0 Td (ges )Tj 0.255 0.255 0.251 rg -0.0336 Tc 2.133 0 Td (in )Tj ET BT /Suspect <>BDC 0.318 0.318 0.314 rg /T1_0 1 Tf -0.035 Tc 8.9276 0 0 12.3 431.98 653.53 Tm (VE )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.0265 0 0 9.9 451.1 653.53 Tm (and )Tj -0.0042 Tc 9.9 0 0 9.9 475.18 653.53 Tm (VT/Tt )Tj 0.0333 Tc 3.298 0 Td (were )Tj 0.459 0.459 0.455 rg 0 Tc -21.007 -1.067 Td (s)Tj 0.318 0.318 0.314 rg 0.442 0 Td (i)Tj 0.459 0.459 0.455 rg 0.242 0 Td (g)Tj 0.318 0.318 0.314 rg 0.006 Tc 0.54 0 Td (nilicuntly )Tj 0.459 0.459 0.455 rg 0.0468 Tc 4.306 0 Td (co)Tj 0.318 0.318 0.314 rg 0.05 Tc 10.0602 0 0 9.9 365.27 642.97 Tm (rr)Tj 0.459 0.459 0.455 rg 0 Tc 9.9 0 0 9.9 372.37 642.97 Tm (e)Tj 0.255 0.255 0.251 rg 0.0182 Tc 0.488 0 Td (lat)Tj 0.4 0.4 0.396 rg -0.002 Tc 1.064 0 Td (ed )Tj 0.318 0.318 0.314 rg 0 Tc 1.415 0 Td (t)Tj 0.459 0.459 0.455 rg 0.283 0 Td (o )Tj 0.4 0.4 0.396 rg -0.0028 Tc 1.026 0 Td (the )Tj ET BT /Suspect <>BDC /C0_0 1 Tf 0 Tc 4 0 0 7.68 430.57 642.97 Tm <00640063004C002D007200650061007E00650020>Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf 0.0149 Tc 9.9 0 0 9.9 470.32 642.97 Tm (in )Tj 0.318 0.318 0.314 rg 0.05 Tc 10.4727 0 0 9.9 482.35 642.97 Tm (FEV )Tj 0 Tc 6.2 0 0 6.2 503.79 640.56 Tm (1 )Tj -0.0185 Tc 9.9 0 0 9.9 511.08 642.97 Tm (\(fig. )Tj 0.459 0.459 0.455 rg -0.014 Tc -21.333 -1.116 Td (3\). )Tj 0.318 0.318 0.314 rg 0 Tc 1.801 0 Td (H)Tj 0.459 0.459 0.455 rg 0.0268 Tc (owever)Tj 0.584 0.584 0.58 rg 0 Tc 3.82 0 Td (, )Tj 0.318 0.318 0.314 rg -0.035 Tc 9.2582 0 0 9.9 364.24 631.92 Tm (in )Tj ET BT /Suspect <>BDC 0.459 0.459 0.455 rg /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 377.62 631.92 Tm (s)Tj 0.318 0.318 0.314 rg 0.448 0 Td (m)Tj 0.459 0.459 0.455 rg 0.768 0 Td (o)Tj 0.318 0.318 0.314 rg 0.0412 Tc 0.59 0 Td (ker)Tj 0.459 0.459 0.455 rg 0 Tc 1.345 0 Td (s)Tj 0.584 0.584 0.58 rg 0.435 0 Td (, )Tj EMC /Suspect <>BDC 0.318 0.318 0.314 rg 0.0011 Tc 0.886 0 Td (th)Tj 0.459 0.459 0.455 rg 0 Tc 0.815 0 Td (e )Tj EMC ET BT /T1_0 1 Tf 9.9 0 0 9.9 440.0494 631.92 Tm (c)Tj 0.318 0.318 0.314 rg 0.0276 Tc 0.494 0 Td (hanges )Tj 0.0149 Tc 3.532 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.2996 0 0 12.3 493.9 631.92 Tm (VE )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.3398 0 0 9.9 511.57 631.92 Tm (and )Tj -0.035 Tc 8.9276 0 0 9.9 300.46 621.36 Tm (VT)Tj 0.682 g 0 Tc 9.9 0 0 9.9 311.75 621.36 Tm (j)Tj 0.4 0.4 0.396 rg -0.0065 Tc 0.357 0 Td (TI, )Tj 0.0423 Tc 2.034 0 Td (allhough )Tj 0.459 0.459 0.455 rg 0 Tc 4.655 0 Td (o)Tj 0.318 0.318 0.314 rg 0.581 0 Td (f )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0011 Tc 9.9 0 0 9.9 398.87 621.36 Tm (th)Tj 0.459 0.459 0.455 rg 0 Tc 0.815 0 Td (e )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.0847 0 0 9.9 419.38 621.36 Tm (sa)Tj 0.318 0.318 0.314 rg 0.0451 Tc 9.9 0 0 9.9 428.62 621.36 Tm (me )Tj 0.0431 Tc 2.085 0 Td (magnitude )Tj 0.05 Tc 9.9203 0 0 9.9 502.46 621.36 Tm (as )Tj 0.0149 Tc 9.9 0 0 9.9 519.76 621.36 Tm (in )Tj 0 Tc -22.151 -1.114 Td (n)Tj 0.459 0.459 0.455 rg 0.476 0 Td (o)Tj 0.318 0.318 0.314 rg 0.639 0 Td (n)Tj 0.459 0.459 0.455 rg 0.472 0 Td (s)Tj 0.318 0.318 0.314 rg 0.05 Tc 10.2534 0 0 9.9 320.62 610.33 Tm (mok)Tj 0.459 0.459 0.455 rg 0 Tc 9.9 0 0 9.9 339.25 610.33 Tm (e)Tj 0.318 0.318 0.314 rg 0.495 0 Td (r)Tj 0.459 0.459 0.455 rg 0.326 0 Td (s)Tj 0.584 0.584 0.58 rg 0.435 0 Td (, )Tj 0.4 0.4 0.396 rg 0.0009 Tc 0.741 0 Td (were )Tj 0.318 0.318 0.314 rg 0 Tc 2.424 0 Td (n)Tj 0.459 0.459 0.455 rg 0.05 Tc 10.1166 0 0 9.9 388.22 610.33 Tm (ot )Tj ET BT /Suspect <>BDC 0.4 0.4 0.396 rg /T1_0 1 Tf 10.043 0 0 9.9 400.7 610.33 Tm (conelated )Tj EMC ET BT 0.318 0.318 0.314 rg /T1_0 1 Tf 0.0011 Tc 9.9 0 0 9.9 448.78 610.33 Tm (to )Tj 0.0215 Tc 1.358 0 Td (the )Tj 0.0298 Tc 1.69 0 Td (decrease )Tj 0.0149 Tc 4.122 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.9856 0 0 9.9 300.44 599.29 Tm (FEV )Tj EMC ET BT 0.4 0.4 0.396 rg /T1_0 1 Tf 0 Tc 6.2 0 0 6.2 320.91 596.89 Tm (1 )Tj 0.318 0.318 0.314 rg -0.0185 Tc 9.9 0 0 9.9 327.72 599.29 Tm (\(fig. )Tj -0.014 Tc 2.036 0 Td (3\). )Tj 0.255 0.255 0.251 rg 0.05 Tc 10.6437 0 0 9.9 309.51 588.24 Tm (ln )Tj 0.318 0.318 0.314 rg 0.0412 Tc 9.9 0 0 9.9 322.09 588.24 Tm (both )Tj 0.0404 Tc 2.221 0 Td (groups )Tj 0.05 Tc 11.1292 0 0 9.9 375.73 588.24 Tm (of )Tj 0.0121 Tc 9.9 0 0 9.9 387.22 588.24 Tm (subjects, )Tj -0.0028 Tc 3.939 0 Td (the )Tj 0.05 Tc 9.9352 0 0 9.9 441.54 588.24 Tm (ETV )Tj 0.255 0.255 0.251 rg 0.0448 Tc 9.9 0 0 9.9 464.55 588.24 Tm (did )Tj 0.05 Tc 10.1333 0 0 9.9 480.95 588.24 Tm (not )Tj 0.318 0.318 0.314 rg 0.0394 Tc 9.9 0 0 9.9 497.66 588.24 Tm (change )Tj 0.4 0.4 0.396 rg 0 Tc -20.028 -1.114 Td (s)Tj 0.255 0.255 0.251 rg 0.0105 Tc 0.442 0 Td (ignificantly )Tj 0.318 0.318 0.314 rg -0.0336 Tc 5.091 0 Td (in )Tj 0.0269 Tc 1.171 0 Td (response )Tj 0.0496 Tc 4.023 0 Td (to )Tj 0.0284 Tc 1.206 0 Td (isotonic )Tj 0.0338 Tc 3.63 0 Td (saline )Tj 0.0378 Tc 2.818 0 Td (inhalation. )Tj 0.255 0.255 0.251 rg 0.05 Tc 9.9506 0 0 9.9 300.41 566.65 Tm (In )Tj 0.318 0.318 0.314 rg 0.0346 Tc 9.9 0 0 9.9 314.39 566.65 Tm (nonsmokers )Tj 0.255 0.255 0.251 rg -0.0045 Tc 5.666 0 Td (it )Tj 0.318 0.318 0.314 rg 0.0155 Tc 1.115 0 Td (increased )Tj 0.0143 Tc 4.406 0 Td (significantly )Tj -0.0207 Tc 5.736 0 Td (by )Tj -0.0299 Tc 1.536 0 Td (568 )Tj -0.0314 Tc 2 0 Td (ml )Tj 0.05 Tc 10.4309 0 0 9.9 299.88 555.12 Tm (\(\261391\) )Tj 9.9904 0 0 9.9 334.94 555.12 Tm (after )Tj 0.0303 Tc 9.9 0 0 9.9 359.03 555.12 Tm (histamine )Tj 0.05 Tc 10.0265 0 0 9.9 404.06 555.12 Tm (and )Tj 0.255 0.255 0.251 rg -0.0207 Tc 9.9 0 0 9.9 424.33 555.12 Tm (by )Tj 0.318 0.318 0.314 rg -0.0043 Tc 1.393 0 Td (338 )Tj 0.0171 Tc 1.901 0 Td (ml )Tj 0 Tc 1.493 0 Td (\()Tj 0.459 0.459 0.455 rg 0.544 0 Td (\261)Tj 0.318 0.318 0.314 rg -0.0067 Tc 0.819 0 Td (256\) )Tj 0.0425 Tc 2.275 0 Td (after )Tj 0.019 Tc -20.986 -1.067 Td (methylcholinc. )Tj 0.255 0.255 0.251 rg 0.05 Tc 9.9506 0 0 9.9 367.13 544.56 Tm (In )Tj 0.318 0.318 0.314 rg 0.0389 Tc 9.9 0 0 9.9 380.5 544.56 Tm (smokers )Tj 0.0215 Tc 4.085 0 Td (the )Tj 0.0423 Tc 1.737 0 Td (corresponding )Tj 0.0401 Tc 6.699 0 Td (mean )Tj 0.255 0.255 0.251 rg 0.0143 Tc -20.655 -1.114 Td (values )Tj 0.0009 Tc 3.007 0 Td (were )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.2217 0 0 9.9 353.18 533.53 Tm (701 )Tj EMC ET BT 0.318 0.318 0.314 rg /T1_0 1 Tf 0.05 Tc 10.0405 0 0 9.9 371.02 533.53 Tm (ml )Tj 10.5939 0 0 9.9 385.31 533.53 Tm (\(\261462\) )Tj 10.0265 0 0 9.9 420.38 533.53 Tm (and )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf 0.0092 Tc 9.9 0 0 9.9 439.64 533.53 Tm (403 )Tj EMC ET BT 0.318 0.318 0.314 rg /T1_0 1 Tf -0.0314 Tc 9.9 0 0 9.9 458.8559 533.53 Tm (ml )Tj 0.4 0.4 0.396 rg 0.05 Tc 10.3541 0 0 9.9 473.16 533.53 Tm (\(\261264\). )Tj 0.255 0.255 0.251 rg 9.9723 0 0 9.9 510.63 533.53 Tm (The )Tj 0.0158 Tc 9.9 0 0 9.9 299.99 522.97 Tm (relative )Tj 0.05 Tc 10.0892 0 0 9.9 334.99 522.97 Tm (RC )Tj 0.318 0.318 0.314 rg 0.0427 Tc 9.9 0 0 9.9 352.22 522.97 Tm (contribution )Tj 0.0496 Tc 5.778 0 Td (to )Tj 0.0215 Tc 1.212 0 Td (the )Tj 0.0342 Tc 1.642 0 Td (generation )Tj 0.05 Tc 10.5727 0 0 9.9 486.62 522.97 Tm (of )Tj 0.0215 Tc 9.9 0 0 9.9 499.18 522.97 Tm (the )Tj 0.255 0.255 0.251 rg -0.035 Tc 9.2996 0 0 9.9 515.5 522.97 Tm (VT )Tj 0.318 0.318 0.314 rg 0.0233 Tc 9.9 0 0 9.9 299.99 511.92 Tm (remained )Tj 0.0457 Tc 4.508 0 Td (the )Tj 0.0355 Tc 1.83 0 Td (same )Tj -0.0336 Tc 2.77 0 Td (in )Tj 0.0272 Tc 1.306 0 Td (each )Tj 0.0304 Tc 2.473 0 Td (experimental )Tj 0.0198 Tc 6.106 0 Td (stage. )Tj 0.165 0.165 0.161 rg 0 Tc 3.093 0 Td ([)Tj 0.318 0.318 0.314 rg 0.363 0 Td (n )Tj 0.0488 Tc -22.506 -1.114 Td (control )Tj 0.0407 Tc 3.345 0 Td (conditions )Tj 0.0152 Tc 4.86 0 Td (before )Tj 0.0303 Tc 2.956 0 Td (histamine )Tj 0.0378 Tc 4.405 0 Td (inhalation, )Tj 0.255 0.255 0.251 rg -0.0045 Tc 4.994 0 Td (it )Tj 0.318 0.318 0.314 rg 0.0252 Tc 0.88 0 Td (was )Tj 0.0232 Tc -21.393 -1.116 Td (39% )Tj 0.05 Tc 11.0226 0 0 9.9 325.31 489.84 Tm (\(\26117\) )Tj 0.0355 Tc 9.9 0 0 9.9 358.46 489.84 Tm (and )Tj 0.0474 Tc 2.228 0 Td (37% )Tj 0.05 Tc 12.5759 0 0 9.9 406.41 489.84 Tm (\(\261II\) )Tj 0.0149 Tc 9.9 0 0 9.9 439.12 489.84 Tm (in )Tj 0.04 Tc 1.462 0 Td (nonsmokers )Tj 0.05 Tc 10.0265 0 0 9.9 511.58 489.84 Tm (and )Tj 0.0309 Tc 9.9 0 0 9.9 299.38 478.81 Tm (smokers )Tj 0.0094 Tc 4.086 0 Td (respectively, )Tj 0.0039 Tc 5.77 0 Td (while )Tj 0.0152 Tc 2.814 0 Td (before )Tj 0.0252 Tc 3.197 0 Td (methylcholine )Tj 0.255 0.255 0.251 rg 0.044 Tc 6.588 0 Td (it )Tj 0.318 0.318 0.314 rg 0.001 Tc -22.441 -1.067 Td (was )Tj 0.0474 Tc 1.88 0 Td (39% )Tj 0.05 Tc 13.1565 0 0 9.9 340.64 468.25 Tm (\(\261 )Tj -0.035 Tc 9.6677 0 0 9.9 355.35 468.25 Tm (17\) )Tj 0.05 Tc 10.0265 0 0 9.9 370.46 468.25 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0366 Tc 9.9 0 0 9.9 389.24 468.25 Tm (40% )Tj EMC /Suspect <>BDC 0.05 Tc 10.8221 0 0 9.9 412.19 468.25 Tm (\(\26120\) )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf 0.0232 Tc 9.9 0 0 9.9 441.59 468.25 Tm (respec)Tj 0.4 0.4 0.396 rg 0 Tc 2.666 0 Td (t)Tj 0.255 0.255 0.251 rg -0.0098 Tc 0.333 0 Td (ively. )Tj 0.318 0.318 0.314 rg 0.05 Tc 10.178 0 0 9.9 496.27 468.25 Tm (During )Tj 0.0269 Tc 9.9 0 0 9.9 299.51 457.21 Tm (histamine-induced )Tj 0.0402 Tc 8.147 0 Td (bronchospasm)Tj 0.459 0.459 0.455 rg 0 Tc 6.287 0 Td (, )Tj 0.318 0.318 0.314 rg 0.0457 Tc 0.546 0 Td (the )Tj 0.05 Tc 10.377 0 0 9.9 463.1 457.21 Tm (data )Tj 0.0171 Tc 9.9 0 0 9.9 484.79 457.21 Tm (were )Tj 0.255 0.255 0.251 rg 0.05 Tc 10.012 0 0 9.9 507.32 457.21 Tm (41% )Tj 0.318 0.318 0.314 rg 0 Tc 14.4 0 0 14.4 299.35 446.16 Tm [(\( )239(\261 )]TJ -0.035 Tc 9.2649 0 0 9.9 314.08 446.16 Tm (18\) )Tj 0.05 Tc 10.0265 0 0 9.9 329.66 446.16 Tm (and )Tj 0.255 0.255 0.251 rg 0 Tc 9.9 0 0 9.9 349.4 446.16 Tm (4 )Tj 0.318 0.318 0.314 rg /T1_1 1 Tf 0.05 Tc 10.3346 0 0 9.5 356.36 446.16 Tm (I% )Tj 0 Tc 9.5 0 0 9.5 373.75 446.16 Tm (\( )Tj /T1_0 1 Tf 14.4 0 0 14.4 378.71 446.16 Tm (\261 )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf 0.05 Tc 10.6244 0 0 9.9 388.25 446.16 Tm (II\) )Tj EMC ET BT /T1_0 1 Tf 0.0149 Tc 9.9 0 0 9.9 404.08 446.16 Tm (in )Tj 0.318 0.318 0.314 rg 0.04 Tc 1.268 0 Td (nonsmokers )Tj 0.05 Tc 10.0265 0 0 9.9 472.22 446.16 Tm (and )Tj 0.0389 Tc 9.9 0 0 9.9 491.86 446.16 Tm (smokers )Tj 0.0094 Tc -19.429 -1.115 Td (respectively. )Tj 0.255 0.255 0.251 rg 0.05 Tc 9.9723 0 0 9.9 355.11 435.12 Tm (The )Tj 0.318 0.318 0.314 rg 0.0423 Tc 9.9 0 0 9.9 375.26 435.12 Tm (corresponding )Tj 0.024 Tc 6.602 0 Td (values )Tj 0.0425 Tc 3.046 0 Td (after )Tj 0.0243 Tc 2.432 0 Td (methyl\255)Tj 0.0305 Tc -19.79 -1.114 Td (choline )Tj 0.255 0.255 0.251 rg 0.0375 Tc 3.493 0 Td (inhalation )Tj 0.318 0.318 0.314 rg 0.0009 Tc 4.759 0 Td (were )Tj 0.0474 Tc 2.365 0 Td (39% )Tj 0.05 Tc 12.6303 0 0 9.9 427.05 424.09 Tm (\(\261 )Tj 0.255 0.255 0.251 rg -0.035 Tc 9.6677 0 0 9.9 441.75 424.09 Tm (17\) )Tj 0.318 0.318 0.314 rg 0.05 Tc 10.0265 0 0 9.9 457.34 424.09 Tm (and )Tj 10.2623 0 0 9.9 476.6 424.09 Tm (44% )Tj 0 Tc 9.9 0 0 9.9 500.52 424.09 Tm (\()Tj 0.459 0.459 0.455 rg 0.496 0 Td (\261 )Tj 0.255 0.255 0.251 rg -0.0247 Tc 0.936 0 Td (14\) )Tj 0.318 0.318 0.314 rg 0.0054 Tc -21.736 -1.067 Td (respectively. )Tj 0.255 0.255 0.251 rg -0.035 Tc 10.655 0 0 10.8 391.63 386.16 Tm (Discussion )Tj ET BT /Suspect <>BDC 0.318 0.318 0.314 rg /T1_0 1 Tf 0.05 Tc 10.2894 0 0 9.9 309.02 369.37 Tm (Our )Tj EMC ET BT /T1_0 1 Tf 0.0179 Tc 9.9 0 0 9.9 333.59 369.37 Tm (results )Tj 0.032 Tc 3.478 0 Td (show )Tj 0.0487 Tc 2.97 0 Td (that, )Tj -0.0336 Tc 2.709 0 Td (in )Tj 0.0277 Tc 1.558 0 Td (terms )Tj 0.05 Tc 11.1292 0 0 9.9 470.29 369.37 Tm (of )Tj 0.0387 Tc 9.9 0 0 9.9 486.73 369.37 Tm (breathing )Tj 0.0404 Tc -18.908 -1.067 Td (pattern, )Tj 0.0215 Tc 3.875 0 Td (the )Tj 0.0327 Tc 1.795 0 Td (respiratory )Tj 0.0173 Tc 5.188 0 Td (responses )Tj 0.4 0.4 0.396 rg 0.0496 Tc 4.557 0 Td (to )Tj 0.318 0.318 0.314 rg 0.0303 Tc 1.359 0 Td (histamine )Tj 0.05 Tc 10.0265 0 0 9.9 511.1 358.81 Tm (and )Tj 0.255 0.255 0.251 rg 0.0252 Tc 9.9 0 0 9.9 299.02 347.76 Tm (methylcholine )Tj 0.318 0.318 0.314 rg 0.0375 Tc 6.636 0 Td (inhalation )Tj 0.0205 Tc 4.944 0 Td (did )Tj 0.0419 Tc 1.996 0 Td (not )Tj 0.255 0.255 0.251 rg 0.0041 Tc 1.98 0 Td (differ )Tj 0.318 0.318 0.314 rg 0.0247 Tc 2.859 0 Td (from )Tj 0.0272 Tc 2.667 0 Td (each )Tj 0.05 Tc 10.1049 0 0 9.9 298.94 336.72 Tm (other )Tj 0.0355 Tc 9.9 0 0 9.9 324.38 336.72 Tm (and )Tj 0.0333 Tc 1.852 0 Td (were )Tj 0.0215 Tc 2.326 0 Td (the )Tj 0.4 0.4 0.396 rg 0.0355 Tc 1.539 0 Td (same )Tj 0.318 0.318 0.314 rg -0.0336 Tc 2.479 0 Td (in )Tj 0.0389 Tc 1.061 0 Td (smokers )Tj 0.0355 Tc 3.834 0 Td (and )Tj 0.255 0.255 0.251 rg 0.0304 Tc 1.9 0 Td (nonsmokers. )Tj 0.318 0.318 0.314 rg 0.0059 Tc -17.509 -1.114 Td (In )Tj 0.0155 Tc 1.46 0 Td (terms )Tj 0.05 Tc 11.1292 0 0 9.9 342.13 325.69 Tm (of )Tj 0.0345 Tc 9.9 0 0 9.9 356.17 325.69 Tm (bronchoconstriction-related )Tj 0.0327 Tc 12.498 0 Td (changes )Tj -0.0336 Tc 3.929 0 Td (in )Tj 0.255 0.255 0.251 rg 0.0223 Tc -22.207 -1.115 Td (drive)Tj 0.459 0.459 0.455 rg 0 Tc 2.176 0 Td (, )Tj 0.255 0.255 0.251 rg 0.0205 Tc 0.838 0 Td (however, )Tj -0.035 Tc 9.8086 0 0 9.9 372.47 314.65 Tm (we )Tj 0.318 0.318 0.314 rg 0.0277 Tc 9.9 0 0 9.9 389.18 314.65 Tm (observed )Tj 0 Tc 4.364 0 Td (a )Tj 0.0221 Tc 1.014 0 Td (significant )Tj 0.255 0.255 0.251 rg 0.0159 Tc 5.007 0 Td (negative )Tj 0.318 0.318 0.314 rg 0.0349 Tc -19.5 -1.115 Td (correlation )Tj 0.0207 Tc 5.054 0 Td (between )Tj 0.0327 Tc 3.771 0 Td (changes )Tj -0.0336 Tc 3.784 0 Td (in )Tj 0.05 Tc 9.9856 0 0 9.9 435.32 303.61 Tm (FEV )Tj /T1_1 1 Tf 0 Tc 5.2 0 0 5.2 456.32 301.69 Tm (1 )Tj /T1_0 1 Tf 0.05 Tc 10.0265 0 0 9.9 462.62 303.61 Tm (and )Tj 0.0246 Tc 9.9 0 0 9.9 481.82 303.61 Tm (changes )Tj 0.0149 Tc 3.735 0 Td (in )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf -0.035 Tc 9.2996 0 0 9.9 299.02 292.56 Tm (VT)Tj 0.459 0.459 0.455 rg 0 Tc 9.9 0 0 9.9 310.56 292.56 Tm (/)Tj 0.318 0.318 0.314 rg 0.331 0 Td (T)Tj 0.165 0.165 0.161 rg 0.728 0 Td (I )Tj EMC ET BT 0.318 0.318 0.314 rg /T1_0 1 Tf 0.0448 Tc 9.9 0 0 9.9 326.7762 292.56 Tm (only )Tj 0.255 0.255 0.251 rg 0.0149 Tc 2.281 0 Td (in )Tj 0.318 0.318 0.314 rg 0.04 Tc 1.171 0 Td (nonsmokers)Tj 0.459 0.459 0.455 rg 0 Tc 5.265 0 Td (. )Tj 0.318 0.318 0.314 rg /T1_3 1 Tf 0.0084 Tc 10 0 0 10 299.63 265.69 Tm (Validity )Tj 0.05 Tc 11.8974 0 0 10 335.9 265.69 Tm (of )Tj 0.4 0.4 0.396 rg -0.0069 Tc 10 0 0 10 347.88 265.69 Tm (the )Tj 0.318 0.318 0.314 rg -0.0008 Tc 1.588 0 Td (comparisons )Tj 0.255 0.255 0.251 rg /T1_0 1 Tf 0.05 Tc 9.9506 0 0 9.9 309.05 248.89 Tm (In )Tj 0.318 0.318 0.314 rg 0.0412 Tc 9.9 0 0 9.9 321.13 248.89 Tm (both )Tj 0.0405 Tc 2.221 0 Td (groups, )Tj 0.0215 Tc 3.545 0 Td (the )Tj 0.255 0.255 0.251 rg 0.05 Tc 10.2291 0 0 9.9 394.04 248.89 Tm (FEV )Tj 0.318 0.318 0.314 rg 0 Tc 6.2 0 0 6.2 415.47 246.97 Tm (1 )Tj 0.024 Tc 9.9 0 0 9.9 421.42 248.89 Tm (values )Tj 0.0448 Tc 2.95 0 Td (obtained )Tj 0.255 0.255 0.251 rg -0.0336 Tc 4.075 0 Td (in )Tj 0 Tc 1.022 0 Td (B )Tj 0.318 0.318 0.314 rg 0.05 Tc 10.0265 0 0 9.9 510.62 248.89 Tm (and )Tj 0.0425 Tc 9.9 0 0 9.9 298.46 238.33 Tm (after )Tj 0.0096 Tc 2.387 0 Td (buffered )Tj 0.0241 Tc 3.815 0 Td (saline )Tj 0.0375 Tc 2.77 0 Td (inhalation )Tj 0.0171 Tc 4.662 0 Td (were )Tj 0.255 0.255 0.251 rg 0.0215 Tc 2.326 0 Td (the )Tj 0.4 0.4 0.396 rg 0.05 Tc 9.9231 0 0 9.9 472.18 238.33 Tm (same )Tj 0.318 0.318 0.314 rg 10.0265 0 0 9.9 496.7 238.33 Tm (and)Tj 0.459 0.459 0.455 rg 0 Tc 9.9 0 0 9.9 512.97 238.33 Tm (, )Tj 0.318 0.318 0.314 rg -0.0336 Tc 0.589 0 Td (in )Tj 0.0402 Tc -22.197 -1.115 Td (bronchospasm)Tj 0.459 0.459 0.455 rg 0 Tc 6.287 0 Td (, )Tj 0.318 0.318 0.314 rg 0.0457 Tc 0.595 0 Td (the )Tj 0.0371 Tc 1.697 0 Td (magnitude )Tj 0.05 Tc 11.1292 0 0 9.9 432.37 227.29 Tm (of )Tj 0.0139 Tc 9.9 0 0 9.9 444.38 227.29 Tm (airflow )Tj 0.0421 Tc 3.345 0 Td (obstruction )Tj 0.0448 Tc -18.085 -1.115 Td (obtained )Tj 0.0425 Tc 4.558 0 Td (after )Tj 0.0303 Tc 2.821 0 Td (histamine )Tj 0.05 Tc 10.0265 0 0 9.9 419.9 216.25 Tm (and )Tj 0.0252 Tc 9.9 0 0 9.9 443.5 216.25 Tm (methylcholine )Tj 0.001 Tc 6.789 0 Td (was )Tj 0.0177 Tc -21.389 -1.115 Td (identical. )Tj 0.255 0.255 0.251 rg 0.05 Tc 10.2656 0 0 9.9 340.71 205.21 Tm (The )Tj 0.318 0.318 0.314 rg 0.0053 Tc 9.9 0 0 9.9 361.33 205.21 Tm (effect )Tj 0.05 Tc 11.1292 0 0 9.9 387.25 205.21 Tm (of )Tj 0.037 Tc 9.9 0 0 9.9 399.75 205.21 Tm (deep )Tj 0.0301 Tc 2.377 0 Td (inspiration )Tj 0.0386 Tc 5.04 0 Td (on )Tj 0.0399 Tc 1.466 0 Td (broncho\255)Tj 0.05 Tc 10.0366 0 0 9.9 299.02 194.65 Tm (motor )Tj 0.0254 Tc 9.9 0 0 9.9 327.82 194.65 Tm (tone )Tj 0.05 Tc 9.9334 0 0 9.9 348.39 194.65 Tm (during )Tj 0.025 Tc 9.9 0 0 9.9 379.12 194.65 Tm (induced )Tj 0.0402 Tc 3.645 0 Td (bronchospasm )Tj 0.0244 Tc 6.542 0 Td (might )Tj 0.255 0.255 0.251 rg 0.05 Tc 9.9208 0 0 9.9 506.87 194.65 Tm (have )Tj 0.0074 Tc 9.9 0 0 9.9 298.96 183.61 Tm (influenced )Tj 0.318 0.318 0.314 rg 0.0215 Tc 4.661 0 Td (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.9856 0 0 9.9 361.4 183.61 Tm (FEY )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_1 1 Tf 0 Tc 5.2 0 0 5.2 382.4 181.21 Tm (1 )Tj 0.318 0.318 0.314 rg /T1_0 1 Tf 0.0275 Tc 9.9 0 0 9.9 389.26 183.61 Tm (measurements )Tj 0.0149 Tc 6.345 0 Td (in )Tj 0 Tc 1.113 0 Td (a )Tj 0.0197 Tc 0.777 0 Td (different )Tj -0.006 Tc 3.935 0 Td (way )Tj 0.0149 Tc -21.34 -1.115 Td (in )Tj 0.0454 Tc 1.316 0 Td (nonsmokers )Tj 0.05 Tc 10.0265 0 0 9.9 368.06 172.57 Tm (and )Tj 0.0309 Tc 9.9 0 0 9.9 389.14 172.57 Tm (smokers )Tj -0.0338 Tc 4.014 0 Td ([13\). )Tj 0.255 0.255 0.251 rg 0.0313 Tc 2.298 0 Td (However, )Tj 0.318 0.318 0.314 rg 0.0496 Tc 4.706 0 Td (to )Tj 0.05 Tc 10.5338 0 0 9.9 511.58 172.57 Tm (our )Tj 0.0238 Tc 9.9 0 0 9.9 298.54 161.52 Tm (knowledge, )Tj -0.0045 Tc 5.182 0 Td (it )Tj 0.0252 Tc 0.88 0 Td (was )Tj 0.0279 Tc 1.939 0 Td (never )Tj 0.0405 Tc 2.61 0 Td (demonstrated )Tj 0.05 Tc 9.9231 0 0 9.9 465.1 161.52 Tm (that )Tj 0.255 0.255 0.251 rg -0.0336 Tc 9.9 0 0 9.9 484.72 161.52 Tm (in )Tj 0.318 0.318 0.314 rg 0.0293 Tc 1.113 0 Td (asymp)Tj 0.165 0.165 0.161 rg 0 Tc 2.762 0 Td (\255)Tj 0.318 0.318 0.314 rg 0.0428 Tc -22.681 -1.114 Td (tomatic )Tj 0.0389 Tc 3.818 0 Td (smokers )Tj 0.0208 Tc 4.182 0 Td (this )Tj -0.0044 Tc 2.076 0 Td (effect )Tj -0.035 Tc 9.3682 0 0 9.9 426.64 150.49 Tm (is )Tj 0.05 Tc 10.1333 0 0 9.9 438.71 150.49 Tm (not )Tj 0.255 0.255 0.251 rg 10.2 0 0 9.9 458.38 150.49 Tm (the )Tj 0.318 0.318 0.314 rg 0.0355 Tc 9.9 0 0 9.9 476.98 150.49 Tm (same )Tj 0.0033 Tc 2.719 0 Td (as )Tj 0.0149 Tc 1.457 0 Td (in )Tj 0.255 0.255 0.251 rg 0.0313 Tc -22.199 -1.116 Td (normals. )Tj ET BT /Suspect <>BDC 0.318 0.318 0.314 rg /T1_0 1 Tf 0.05 Tc 9.986 0 0 9.9 340.7 139.44 Tm (On )Tj EMC ET BT /T1_0 1 Tf 0.0215 Tc 9.9 0 0 9.9 359.5 139.44 Tm (the )Tj 0.05 Tc 10.1049 0 0 9.9 377.18 139.44 Tm (other )Tj 0.0486 Tc 9.9 0 0 9.9 405.11 139.44 Tm (hand)Tj 0.459 0.459 0.455 rg 0 Tc 2.168 0 Td (, )Tj 0.318 0.318 0.314 rg 0.05 Tc 10.1194 0 0 9.9 433.82 139.44 Tm (at )Tj 0.0272 Tc 9.9 0 0 9.9 447.25 139.44 Tm (each )Tj 0.0304 Tc 2.424 0 Td (experimental )Tj 0.0295 Tc -17.506 -1.066 Td (stage, )Tj 0.0031 Tc 3.213 0 Td (we )Tj 0.0356 Tc 1.938 0 Td (measured )Tj 0.255 0.255 0.251 rg 0 Tc 4.895 0 Td (F)Tj 0.4 0.4 0.396 rg -0.0101 Tc 0.677 0 Td (EV )Tj 0.318 0.318 0.314 rg 0 Tc 6.2 0 0 6.2 417.87 126.48 Tm (1 )Tj 0.255 0.255 0.251 rg 0.05 Tc 10.3342 0 0 9.9 429.09 128.89 Tm (thr)Tj 0.4 0.4 0.396 rg 0.0065 Tc 9.9 0 0 9.9 441.49 128.89 Tm (ee )Tj 0.318 0.318 0.314 rg 0.0027 Tc 1.658 0 Td (times, )Tj 0.05 Tc 10.1194 0 0 9.9 489.98 128.89 Tm (at )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0066 Tc 9.9 0 0 9.9 505.32 128.89 Tm (30 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 522.5757 128.89 Tm (s )Tj 0.255 0.255 0.251 rg 0.0206 Tc -22.636 -1.116 Td (intervals)Tj 0.4 0.4 0.396 rg 0 Tc 3.678 0 Td (, )Tj 0.318 0.318 0.314 rg 0.0351 Tc 0.693 0 Td (retaining )Tj 0.0286 Tc 4.258 0 Td (only )Tj 0.0215 Tc 2.335 0 Td (the )Tj 0.0164 Tc 1.7 0 Td (best )Tj 0.0182 Tc 2.13 0 Td (value)Tj 0.459 0.459 0.455 rg 0 Tc 2.308 0 Td (. )Tj 0.255 0.255 0.251 rg 0.05 Tc 9.9506 0 0 9.9 474.17 117.84 Tm (In )Tj 0.318 0.318 0.314 rg 0.0468 Tc 9.9 0 0 9.9 487.21 117.84 Tm (broncho\255)Tj 0.0485 Tc -19.118 -1.115 Td (spasm )Tj 0.0031 Tc 2.922 0 Td (we )Tj 0.0205 Tc 1.398 0 Td (did )Tj 0.05 Tc 10.1333 0 0 9.9 357.11 106.8 Tm (not )Tj 0.0349 Tc 9.9 0 0 9.9 373.34 106.8 Tm (observe )Tj 0.0355 Tc 3.539 0 Td (any )Tj 0.255 0.255 0.251 rg 0.04 Tc 1.794 0 Td (con)Tj 0.4 0.4 0.396 rg 0.0233 Tc 1.547 0 Td (sistent )Tj 0.318 0.318 0.314 rg 0.0394 Tc 2.913 0 Td (change )Tj -0.0336 Tc 3.299 0 Td (in )Tj 0.0215 Tc 1.073 0 Td (the )Tj 0.0319 Tc -21.782 -1.115 Td (second )Tj 0.05 Tc 10.5727 0 0 9.9 331.58 95.76 Tm (or )Tj 0.0379 Tc 9.9 0 0 9.9 345.1 95.76 Tm (third )Tj 0.0227 Tc 2.473 0 Td (value, )Tj 0.05 Tc 9.9203 0 0 9.9 398.78 95.76 Tm (as )Tj 0.0427 Tc 9.9 0 0 9.9 411.74 95.76 Tm (compared )Tj 0.0496 Tc 4.711 0 Td (to )Tj 0.0457 Tc 1.261 0 Td (the )Tj -0.007 Tc 1.736 0 Td (first )Tj 0.0404 Tc 2.037 0 Td (one, )Tj ET endstream endobj 9 0 obj <>stream Hd͊zy8 >sRhF^#y QG#Oç==o/ϧ;c_mӷKv|~_oo~y>}~W=|z>{O݇q~?>Ï?o+~ߒ~;%zΏx߽w;>lp?(O?{wٸ^ PZUuTGu^5P5FjFDMԤU PjVjUmFmک]uPuNNE]E5|| _#_k55|| _#_k55|| _#_k55|| 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0 0 9 335.421 655.917 Tm (3.0 )Tj EMC ET BT 0.255 0.255 0.247 rg /T1_0 1 Tf -0.004 Tc 9 0 0 9 375.804 655.917 Tm (4.6 )Tj -0.0093 Tc 5.013 0 Td (4.71 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0262 Tc 9 0 0 9 459.324 655.917 Tm (4.60 )Tj EMC /Suspect <>BDC 0.0026 Tc 4.32 -0.053 Td (4.53\2610.87 )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 69.02 645.36 Tm (-)Tj 0.255 0.255 0.247 rg 0.0199 Tc 0.552 0 Td (Methylcholine )Tj -0.0212 Tc 9 0 0 9 168.36 644.89 Tm (5.1 )Tj 0.0054 Tc 4.533 0 Td (5.2 )Tj 0.0147 Tc 4.48 0 Td (5.12 )Tj 0.0335 Tc 5.016 0 Td (3.2 )Tj -0.0081 Tc 4.539 0 Td (2.95 )Tj -0.0093 Tc 4.481 0 Td (4.75 )Tj 0.0084 Tc 5.013 0 Td (4.74 )Tj 0.0226 Tc 4.267 0 Td (4.3 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0026 Tc 9 0 0 9 498.201 644.89 Tm (4.41\2610.87 )Tj EMC /Suspect <>BDC 0.0129 Tc 8.8 0 0 8.8 64.23 623.76 Tm (Control )Tj EMC ET BT /T1_0 1 Tf 0.0044 Tc 8.8 0 0 8.8 94.0444 623.76 Tm (Before: )Tj ET BT /Suspect <>BDC 0.416 0.42 0.408 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 69.026 612.7336 Tm (-)Tj 0.255 0.255 0.247 rg 0.0133 Tc 0.552 0 Td (Histamine )Tj EMC /Suspect <>BDC 0.18 0.184 0.176 rg 0.0321 Tc 9 0 0 9 168.36 612.24 Tm (5.0 )Tj EMC ET BT /T1_0 1 Tf 0.0147 Tc 9 0 0 9 208.68 612.24 Tm (5.25 )Tj 0.255 0.255 0.247 rg 0.0054 Tc 4.533 0 Td (5.3 )Tj -0.0021 Tc 5.069 0 Td (3.25 )Tj 0.18 0.184 0.176 rg -0.0081 Tc 4.486 0 Td (2.95 )Tj 0.255 0.255 0.247 rg -0.004 Tc 4.481 0 Td (4.5 )Tj -0.0271 Tc 5.013 0 Td (4.71 )Tj -0.0093 Tc 4.32 0 Td (4.65 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0026 Tc 9 0 0 9 498.201 612.24 Tm (4.45\2610.88 )Tj EMC ET BT 0.557 0.561 0.553 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 68.54 601.68 Tm (-)Tj 0.255 0.255 0.247 rg 0.0199 Tc 0.552 0 Td (Methylcholine )Tj -0.003 Tc 9 0 0 9 168.36 601.68 Tm (5.25 )Tj 0.0321 Tc 4.48 -0.052 Td (5.2 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9 0 0 9 249.477 601.212 Tm (5.0 )Tj EMC ET BT /T1_0 1 Tf 0.0068 Tc 9 0 0 9 294.621 601.212 Tm (3.3 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0096 Tc 9 0 0 9 335.472 601.212 Tm (2.90 )Tj EMC ET BT 0.18 0.184 0.176 rg /T1_0 1 Tf -0.004 Tc 9 0 0 9 375.801 601.212 Tm (4.8 )Tj 0.0084 Tc 5.013 0 Td (4.74 )Tj 0.255 0.255 0.247 rg -0.0093 Tc 4.32 0.052 Td (4.45 )Tj ET BT /Suspect <>BDC 0.18 0.184 0.176 rg /T1_0 1 Tf 0.0262 Tc 9 0 0 9 498.201 601.212 Tm (4.46)Tj 0.337 0.337 0.329 rg 0.0137 Tc 1.763 0 Td (\2610.88 )Tj EMC ET BT 0.255 0.255 0.247 rg /T1_0 1 Tf 0.0199 Tc 8.8 0 0 8.8 64.3 579.61 Tm (After )Tj 0.0183 Tc 2.395 0 Td (Inhalation )Tj 0.0007 Tc 4.416 0 Td (of: )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 0.0429 Tc 8.8 0 0 8.8 68.5328 569.05 Tm (-Histamine )Tj EMC ET BT 0.255 0.255 0.247 rg /T1_0 1 Tf 0.0226 Tc 9 0 0 9 167.96 568.56 Tm (4.4 )Tj 0.0084 Tc 4.48 0 Td (4.35 )Tj -0.004 Tc 4.587 0 Td (4.5 )Tj -0.0081 Tc 5.012 0 Td (2.25 )Tj -0.0293 Tc 4.558 0 Td (1.3 )Tj 0.0245 Tc 4.456 0 Td (2.4 )Tj -0.0081 Tc 5.067 0 Td (2.28 )Tj -0.0199 Tc 4.261 0 Td (3.1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0053 Tc 9 0 0 9 498.152 568.56 Tm (3.07\2611.21 )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 68.54 558 Tm (-)Tj 0.255 0.255 0.247 rg 0.0154 Tc 0.607 0 Td (Methylcholine )Tj -0.0093 Tc 9 0 0 9 167.96 557.53 Tm (4.65 )Tj -0.0022 Tc 4.532 0 Td (2.8 )Tj 0.0084 Tc 4.481 0 Td (4.45 )Tj 0.0245 Tc 5.066 0 Td (2.2 )Tj -0.0026 Tc 4.558 0 Td (1.2 )Tj -0.0081 Tc 4.456 0 Td (2.15 )Tj 0.0096 Tc 5.067 0 Td (2.82 )Tj 0.0335 Tc 4.261 0 Td (3.4 )Tj 0.003 Tc 4.272 0 Td (2.96\2611.17 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.928 0 0 8.8 63.68 536.41 Tm (Smokers )Tj EMC ET BT /T1_0 1 Tf 0.0262 Tc 8.8 0 0 8.8 63.32 525.36 Tm (Baseline )Tj 0.18 0.184 0.176 rg 0.0135 Tc 3.818 0 Td (Before: )Tj ET BT /Suspect <>BDC 0.416 0.42 0.408 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 68.0544 514.3336 Tm (-)Tj 0.18 0.184 0.176 rg 0.0201 Tc 0.607 0 Td (Histamine )Tj EMC ET BT 0.255 0.255 0.247 rg /T1_0 1 Tf 0.0084 Tc 9 0 0 9 167.96 514.33 Tm (4.52 )Tj 4.48 -0.053 Td (4.33 )Tj -0.0021 Tc 4.58 0 Td (3.53 )Tj 0.18 0.184 0.176 rg -0.0081 Tc 5.019 0 Td (2.85 )Tj 0.255 0.255 0.247 rg 0.0156 Tc 4.474 0 Td (3.15 )Tj -0.0199 Tc 4.533 0 Td (3.61 )Tj 0.0084 Tc 5.02 0 Td (4.37 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0053 Tc 9 0 0 9 498.134 513.853 Tm (3.76\2610.65 )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 68.06 503.28 Tm (-)Tj 0.255 0.255 0.247 rg 0.0245 Tc 0.552 0 Td (Methylcholine )Tj -0.0093 Tc 9 0 0 9 167.96 503.28 Tm (4.26 )Tj 0.0262 Tc 4.48 0 Td (4.44 )Tj 0.0156 Tc 4.58 0 Td (3.52 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0096 Tc 9 0 0 9 294.671 502.812 Tm (2.90 )Tj EMC ET BT /T1_0 1 Tf -0.0021 Tc 9 0 0 9 334.937 502.812 Tm (3.15 )Tj 0.18 0.184 0.176 rg 0 Tc 4.533 0.052 Td (3)Tj 0.337 0.337 0.329 rg -0.035 Tc 8.8624 0 0 9 380.94 503.28 Tm (.45 )Tj 0.255 0.255 0.247 rg 0.0084 Tc 9 0 0 9 420.92 503.28 Tm (4.59 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0053 Tc 9 0 0 9 498.14 502.812 Tm (3.76\2610.67 )Tj EMC /Suspect <>BDC 0.022 Tc 8.8 0 0 8.8 63.27 481.69 Tm (Control )Tj EMC ET BT /T1_0 1 Tf 0.0135 Tc 8.8 0 0 8.8 93.0844 481.69 Tm (Before: )Tj ET BT /Suspect <>BDC 0.18 0.184 0.176 rg /T1_0 1 Tf 0.0429 Tc 8.8 0 0 8.8 68.066 470.646 Tm (-Histamine )Tj EMC ET BT 0.255 0.255 0.247 rg /T1_0 1 Tf 0.0084 Tc 9 0 0 9 167.48 470.16 Tm [(4.43 )-2491(4.16 )]TJ ET BT /Suspect <>BDC /T1_0 1 Tf 0.0156 Tc 9 0 0 9 249.02 470.16 Tm (3.40 )Tj EMC ET BT /T1_0 1 Tf -0.0259 Tc 9 0 0 9 294.668 470.16 Tm (2.68 )Tj 0.0156 Tc 4.474 -0.052 Td (3.15 )Tj -0.0021 Tc 4.533 0.052 Td (3.57 )Tj -0.0093 Tc 5.02 0 Td (4.41 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0053 Tc 9 0 0 9 498.131 469.692 Tm (3.69\2610.67 )Tj EMC ET BT 0.18 0.184 0.176 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 68.06 459.61 Tm (-)Tj 0.0199 Tc 0.552 0 Td (Methylcholine )Tj 0.255 0.255 0.247 rg 0.0084 Tc 9 0 0 9 167.48 459.12 Tm [(4.47 )-2491(4.55 )]TJ 0.0156 Tc 9.06 -0.052 Td (3.38 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0096 Tc 9 0 0 9 294.668 459.12 Tm (2.64 )Tj EMC ET BT /T1_0 1 Tf 0.0335 Tc 9 0 0 9 334.934 459.12 Tm (3.2 )Tj -0.0199 Tc 4.533 0 Td (3.51 )Tj 0.0084 Tc 5.02 0 Td (4.45 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0053 Tc 9 0 0 9 498.131 458.652 Tm (3.73\2610.76 )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf 0.0199 Tc 8.8 0 0 8.8 63.34 437.53 Tm (After )Tj 0.255 0.255 0.247 rg 0.0183 Tc 2.395 0 Td (Inhalation )Tj 0.0007 Tc 4.47 0 Td (of: )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 0.0429 Tc 8.8 0 0 8.8 68.048 426.486 Tm (-Histamine )Tj EMC ET BT 0.255 0.255 0.247 rg /T1_0 1 Tf 0.0096 Tc 9 0 0 9 167.47 426 Tm [(2.62 )-2485(2.32 )]TJ 0.0094 Tc 9.091 0 Td (1.82 )Tj 0.0096 Tc 4.989 0 Td (2.36 )Tj -0.0081 Tc 4.533 0 Td (2.85 )Tj 0.0274 Tc 4.48 0 Td (2.72 )Tj -0.0021 Tc 5.061 0 Td (3.33 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.003 Tc 9 0 0 9 498.184 425.532 Tm (2.58\2610.48 )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 67.58 415.44 Tm (-)Tj 0.255 0.255 0.247 rg 0.0199 Tc 0.607 0 Td (Methylcholine )Tj -0.0084 Tc 9 0 0 9 168.17 415.44 Tm (1.94 )Tj 4.48 -0.052 Td (1.93 )Tj 0.0096 Tc 4.456 0 Td (2.25 )Tj -0.0262 Tc 5.144 0 Td (1.99 )Tj -0.0022 Tc 4.402 0.052 Td (2.8 )Tj 0.0096 Tc 4.533 -0.052 Td (2.75 )Tj 0.0156 Tc 5.061 0.052 Td (3.57 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.003 Tc 9 0 0 9 498.182 414.972 Tm (2.46\2610.61 )Tj EMC /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 8.5302 0 0 7.2 321.59 382.81 Tm (VTm] )Tj EMC /Suspect <>BDC /T1_0 1 Tf 8.8889 0 0 8.8 62.44 371.76 Tm (NonSmokers )Tj EMC ET BT /T1_0 1 Tf 0.0184 Tc 8.8 0 0 8.8 62.84 360.72 Tm (Baseline )Tj 0.18 0.184 0.176 rg 0.0135 Tc 3.764 0 Td (Before: )Tj 0.255 0.255 0.247 rg 0 Tc -3.28 -1.253 Td (-)Tj ET BT /Suspect <>BDC 0.18 0.184 0.176 rg /T1_0 1 Tf 8.8 0 0 8.8 72.4408 349.6936 Tm (H)Tj 0.337 0.337 0.329 rg -0.0042 Tc 0.76 0 Td (istaroi)Tj 0.18 0.184 0.176 rg 0.0421 Tc 2.461 0 Td (ne )Tj EMC /Suspect <>BDC 0.255 0.255 0.247 rg 0.0159 Tc 9 0 0 9 159.24 349.69 Tm (586\26180 )Tj EMC ET BT /T1_0 1 Tf 0.014 Tc 9 0 0 9 202.944 349.69 Tm (724\26199 )Tj 0.0161 Tc 4.58 -0.053 Td (867\26192 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0121 Tc 9 0 0 9 287.481 349.69 Tm (490\26177 )Tj EMC ET BT /T1_0 1 Tf 0.0058 Tc 9 0 0 9 329.178 349.69 Tm (357\26184 )Tj -0.0073 Tc 4.799 0 Td (643\26195 )Tj 0.0121 Tc 4.808 0 Td (444\26163 )Tj 0.18 0.184 0.176 rg 0.0083 Tc 4.633 -0.053 Td (713\261199 )Tj ET BT /Suspect <>BDC 0.255 0.255 0.247 rg /T1_0 1 Tf -0.0095 Tc 9 0 0 9 502.932 349.213 Tm (603\261168 )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 67.1 339.12 Tm (-)Tj 0.18 0.184 0.176 rg 0.0199 Tc 0.552 0 Td (Methylcholine )Tj ET BT /Suspect <>BDC 0.255 0.255 0.247 rg /T1_0 1 Tf 0.0159 Tc 9 0 0 9 159.24 338.65 Tm (534\26170 )Tj EMC /Suspect <>BDC 0.0052 Tc 4.8 0 Td (506\26153 )Tj EMC ET BT /T1_0 1 Tf 0.0054 Tc 9 0 0 9 244.164 338.65 Tm (894\26184 )Tj 0.0052 Tc 4.804 0 Td (524\26175 )Tj 0.0015 Tc 4.542 0 Td (426\26185 )Tj -0.0079 Tc 4.898 0 Td (528\261151 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0015 Tc 9 0 0 9 415.641 338.65 Tm (480\26193 )Tj EMC /Suspect <>BDC 0.0083 Tc 4.632 0 Td (604\261190 )Tj EMC ET BT /T1_0 1 Tf -0.0079 Tc 9 0 0 9 502.923 338.65 Tm (562\261143 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0129 Tc 8.8 0 0 8.8 61.83 317.05 Tm (Control )Tj EMC ET BT 0.18 0.184 0.176 rg /T1_0 1 Tf 0.0135 Tc 8.8 0 0 8.8 92.1196 317.05 Tm (Before: )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 66.6172 305.9972 Tm (-)Tj 0.18 0.184 0.176 rg 0.0201 Tc 0.607 0 Td (Histamine )Tj EMC ET BT 0.255 0.255 0.247 rg /T1_0 1 Tf 0.0121 Tc 9 0 0 9 158.84 306 Tm (434\26183 )Tj -0.0073 Tc 4.9 0 Td (776\26198 )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf -0.0043 Tc 9 0 0 9 239.687 305.532 Tm (1000\261125 )Tj EMC ET BT 0.255 0.255 0.247 rg /T1_0 1 Tf 0.0121 Tc 9 0 0 9 287 305.532 Tm (435\26185 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0049 Tc 9 0 0 9 328.697 305.532 Tm (308\26185 )Tj EMC /Suspect <>BDC -0.0073 Tc 4.853 0 Td (704\26195 )Tj EMC /Suspect <>BDC 0.0015 Tc 4.807 0.052 Td (490\26193 )Tj EMC ET BT /T1_0 1 Tf 0.001 Tc 9 0 0 9 457.316 305.532 Tm (581\261155 )Tj 0.0099 Tc 5.013 0 Td (591\261224 )Tj 0 Tc 8.8 0 0 8.8 66.62 294.97 Tm (-)Tj 0.0154 Tc 0.607 0 Td (Methylcholine )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0052 Tc 9 0 0 9 158.76 294.97 Tm (506\26195 )Tj EMC /Suspect <>BDC -0.0073 Tc 4.908 0 Td (608\26153 )Tj EMC ET BT /T1_0 1 Tf 0.0161 Tc 9 0 0 9 239.211 294.493 Tm (1133\26192 )Tj 0.0121 Tc 5.31 0.053 Td (423\26156 )Tj -0.0074 Tc 4.633 -0.053 Td (382\261113 )Tj 0.001 Tc 4.798 0.053 Td (525\261147 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9 0 0 9 415.557 294.97 Tm (503\261118 )Tj EMC ET BT /T1_0 1 Tf 0.0083 Tc 9 0 0 9 456.849 294.493 Tm (664\261153 )Tj 0.001 Tc 5.066 0 Td (593\261236 )Tj 0.0199 Tc 8.8 0 0 8.8 61.9 273.37 Tm (After )Tj 0.0244 Tc 2.395 0 Td (Inhalation )Tj 0.0007 Tc 4.47 0 Td (of: )Tj 0.0429 Tc -6.33 -1.2 Td (-Histamine )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0083 Tc 9 0 0 9 159.25 262.33 Tm (632\261100 )Tj EMC ET BT /T1_0 1 Tf -0.0175 Tc 9 0 0 9 200.542 262.33 Tm (926)Tj 0.416 0.42 0.408 rg 0.0249 Tc 1.45 0 Td (\2611)Tj 0.255 0.255 0.247 rg -0.0058 Tc 1.108 0 Td (59 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0072 Tc 9 0 0 9 239.692 262.33 Tm (1022\26164 )Tj EMC ET BT /T1_0 1 Tf -0.0095 Tc 9 0 0 9 287.41 261.844 Tm (684\261141 )Tj -0.0006 Tc 4.587 0 Td (638\261148 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0084 Tc 9 0 0 9 369.499 262.33 Tm (930\261117 )Tj EMC ET BT /T1_0 1 Tf -0.0006 Tc 9 0 0 9 416.047 262.33 Tm (638\261146 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0157 Tc 9 0 0 9 456.916 262.33 Tm (489\261120 )Tj EMC ET BT /T1_0 1 Tf -0.0006 Tc 9 0 0 9 502.456 261.844 Tm (745\261188 )Tj 0.416 0.42 0.408 rg 0 Tc 8.8 0 0 8.8 66.62 251.29 Tm (-)Tj 0.255 0.255 0.247 rg 0.0199 Tc 0.552 0 Td (Methylcholine )Tj 0.0052 Tc 9 0 0 9 158.76 251.29 Tm (584\26169 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0083 Tc 9 0 0 9 200.061 251.29 Tm (785\261110 )Tj EMC ET BT /T1_0 1 Tf -0.0043 Tc 9 0 0 9 239.211 250.804 Tm (1239\261153 )Tj -0.0006 Tc 5.303 0.054 Td (786\261151 )Tj 0.0033 Tc 4.587 0 Td (715\26199 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0005 Tc 9 0 0 9 369.504 251.29 Tm (900\261121 )Tj EMC ET BT /T1_0 1 Tf -0.0054 Tc 9 0 0 9 415.566 251.29 Tm (551\26178 )Tj 0.0188 Tc 4.587 0 Td (599\261152 )Tj -0.0095 Tc 5.122 0 Td (771\261224 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.928 0 0 8.8 61.76 229.69 Tm (Smokers )Tj EMC ET BT /T1_0 1 Tf 0.0184 Tc 8.8 0 0 8.8 61.88 219.13 Tm (Baseline )Tj 0.0135 Tc 3.764 0 Td (Before: )Tj 0.337 0.337 0.329 rg 0.0368 Tc -3.225 -1.255 Td (-Histamine )Tj ET BT /Suspect <>BDC 0.255 0.255 0.247 rg /T1_0 1 Tf 0.0083 Tc 9 0 0 9 158.78 207.61 Tm (755\261207 )Tj EMC /Suspect <>BDC 4.587 0 Td (707\261142 )Tj EMC ET BT /T1_0 1 Tf 0.0058 Tc 9 0 0 9 241.346 207.61 Tm (381\26166 )Tj 0.0121 Tc 5.073 0 Td (483\26174 )Tj 0.0015 Tc 4.587 0 Td (432\26145 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0173 Tc 9 0 0 9 369.506 207.61 Tm (913\261100 )Tj EMC /Suspect <>BDC 0.0033 Tc 5.173 0 Td (769\26190 )Tj EMC /Suspect <>BDC -0.0095 Tc 9.599 0 Td (634\261201 )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 66.62 197.05 Tm (-)Tj 0.255 0.255 0.247 rg -0.005 Tc 0.552 0 Td (Methylcholi.ne )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0043 Tc 9 0 0 9 154.25 196.57 Tm (1058\261241 )Tj EMC ET BT /T1_0 1 Tf 0.0101 Tc 9 0 0 9 199.997 196.57 Tm (885\261122 )Tj 0.0058 Tc 4.54 0 Td (394\26153 )Tj -0.0054 Tc 5.118 0 Td (521\26151 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0068 Tc 9 0 0 9 328.283 196.57 Tm (468\261100 )Tj EMC ET BT 0.18 0.184 0.176 rg /T1_0 1 Tf 0.0052 Tc 9 0 0 9 369.485 196.57 Tm (557\26184 )Tj 0.255 0.255 0.247 rg -0.0052 Tc 5.169 0 Td (842\26181 )Tj -0.0183 Tc 9.606 0 Td (675\261251 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0129 Tc 8.8 0 0 8.8 61.35 174.97 Tm (Control )Tj EMC ET BT /T1_0 1 Tf 0.0135 Tc 8.8 0 0 8.8 91.1644 174.97 Tm (Before: )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0429 Tc 8.8 0 0 8.8 66.146 163.926 Tm (-Histamine )Tj EMC /Suspect <>BDC 0.011 Tc 9 0 0 9 154.25 163.93 Tm (1061\261236 )Tj EMC /Suspect <>BDC 0.0083 Tc 5.089 -0.054 Td (630\261120 )Tj EMC ET BT /T1_0 1 Tf 0.0121 Tc 9 0 0 9 240.92 163.444 Tm (493\26166 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.001 Tc 9 0 0 9 285.002 163.444 Tm (548\261109 )Tj EMC /Suspect <>BDC -0.0092 Tc 4.809 0.054 Td (410\26151 )Tj EMC ET BT /T1_0 1 Tf 0.0172 Tc 9 0 0 9 369.503 163.93 Tm (743\261114 )Tj 0.337 0.337 0.329 rg 0.0052 Tc 4.904 0 Td (573\26177 )Tj 0.255 0.255 0.247 rg -0.0006 Tc 9.921 0 Td (637\261214 )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 66.14 153.37 Tm (-)Tj EMC ET BT 0.18 0.184 0.176 rg /T1_0 1 Tf 0.0245 Tc 8.8 0 0 8.8 70.5224 153.37 Tm (Methylcholine )Tj ET BT /Suspect <>BDC 0.255 0.255 0.247 rg /T1_0 1 Tf 0.011 Tc 9 0 0 9 154.25 152.89 Tm (1387\261170 )Tj EMC /Suspect <>BDC 0.0083 Tc 5.037 0.053 Td (780\261112 )Tj EMC /Suspect <>BDC 0.0015 Tc 4.593 -0.053 Td (409\26156 )Tj EMC ET BT /T1_0 1 Tf 0.0052 Tc 9 0 0 9 284.516 153.367 Tm (525\26157 )Tj -0.0054 Tc 4.853 -0.053 Td (519\26183 )Tj 0.0052 Tc 4.587 0 Td (567\26198 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0083 Tc 9 0 0 9 413.18 153.367 Tm (740\261109 )Tj EMC /Suspect <>BDC -0.0095 Tc 9.973 -0.053 Td (704\261328 )Tj EMC ET BT /T1_0 1 Tf 0.0199 Tc 8.8 0 0 8.8 61.42 131.29 Tm (After )Tj 0.0183 Tc 2.395 0 Td (Inhalation )Tj -0.0266 Tc 4.47 0 Td (of: )Tj 0.0429 Tc -6.33 -1.31 Td (-Histamine )Tj 0.0033 Tc 9 0 0 9 152.33 119.76 Tm (1388\261284 )Tj -0.0043 Tc 4.853 0 Td (1565\261368 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0006 Tc 9 0 0 9 238.928 119.76 Tm (690\261119 )Tj EMC ET BT /T1_0 1 Tf 0.0012 Tc 9 0 0 9 282.56 119.76 Tm (881\261148 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0099 Tc 9 0 0 9 325.796 119.76 Tm (567\261105 )Tj EMC /Suspect <>BDC 0.011 Tc 4.352 0 Td (1051\261137 )Tj EMC ET BT /T1_0 1 Tf -0.0006 Tc 9 0 0 9 416.048 119.76 Tm (685\261136 )Tj 0.0084 Tc 9.601 0.054 Td (975\261379 )Tj ET BT /Suspect <>BDC 0.416 0.42 0.408 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 65.66 108.72 Tm (-)Tj EMC ET BT 0.18 0.184 0.176 rg /T1_0 1 Tf 0.0199 Tc 8.8 0 0 8.8 71.0016 108.72 Tm (Methylcholine )Tj ET BT /Suspect <>BDC 0.255 0.255 0.247 rg /T1_0 1 Tf 0.0033 Tc 9 0 0 9 151.85 108.72 Tm (1160\261206 )Tj EMC ET BT /T1_0 1 Tf 9 0 0 9 195.527 108.72 Tm (1226\261264 )Tj 0.18 0.184 0.176 rg 0.0015 Tc 4.777 0 Td (479\26158 )Tj ET BT /Suspect <>BDC 0.255 0.255 0.247 rg /T1_0 1 Tf -0.0006 Tc 9 0 0 9 282.143 108.72 Tm (762\261103 )Tj EMC /Suspect <>BDC 0.0083 Tc 4.853 0 Td (759\261202 )Tj EMC /Suspect <>BDC 4.8 0.053 Td (711\261101 )Tj EMC ET BT /T1_0 1 Tf 0.0084 Tc 9 0 0 9 415.577 109.197 Tm (999\261219 )Tj -0.0077 Tc 9.647 0 Td (876\261265 )Tj ET endstream endobj 33 0 obj <>stream jP ftypjp2 jp2 jpxbjpx rreq@ .-jp2hihdrcolr jp2cOQ)R \#B@HHPHHPHHPHHP((( ߇A@&v e3kN=؅hiURׂ~NN)bh1B_la!/kX&SR_j !ءX{Ă`ڝ!H2:@ſaZmϽS넙Ê_+-`֔x䥼`o#,`8CLՄyΈgq* D3ZO x(8N3r} y< /#/|/R%hn>m_<)7x,}ihșt"sٸ=bX CB˻`tE-re։ zDvV<7l;L~d-_j"ï5ܓӡ:a#c2Tg0-,>ɭHn{(SGI'wZ`&ļZS ^d99gwaδr@8b N3X Z}תo@kY:rb7x*Q~i`*1v u߃ Ԩ?#Nih ف w? 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Tc 9.3 0 0 9.3 414.6749 645.8529 Tm (2)Tj 0.372 0.376 0.365 rg 0.553 0 Td (.)Tj 0.263 0.267 0.255 rg 0.17 0 Td [(2 )23(\261 )]TJ ET BT /Suspect <>BDC /T1_0 1 Tf 0.0052 Tc 9.3 0 0 9.3 435.2651 645.8529 Tm (0.5 )Tj EMC /Suspect <>BDC -0.035 Tc 9.0949 0 0 9.3 481.39 645.85 Tm (2.1)Tj 0.372 0.376 0.365 rg 0 Tc 9.3 0 0 9.3 494.39 645.85 Tm (\261)Tj 0.263 0.267 0.255 rg -0.0207 Tc 0.816 0 Td (0.6 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 11.3501 0 0 13.6 47.99 621.36 Tm (nrrtot; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.031 Tc 8.8 0 0 8.8 92.2 622.8 Tm (NS )Tj EMC /Suspect <>BDC -0.0256 Tc 9.3 0 0 9.3 127.1 622.8 Tm (0.35 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.3 0 0 9.3 144.4724 622.8 Tm (\261 )Tj ET BT /Suspect <>BDC 0.184 0.184 0.173 rg /T1_0 1 Tf -0.0256 Tc 9.3 0 0 9.3 152.5448 622.8 Tm (0.08 )Tj EMC /Suspect <>BDC 0.263 0.267 0.255 rg 4.387 0.053 Td (0.33 )Tj EMC /Suspect <>BDC 0.0464 Tc 1.919 0 Td (\2610.06 )Tj EMC /Suspect <>BDC 0.05 Tc 9.3259 0 0 9.3 265.82 623.29 Tm (0.37\2610.06 )Tj EMC /Suspect <>BDC -0.0256 Tc 9.3 0 0 9.3 337.82 623.76 Tm (0.35 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.3 0 0 9.3 355.6667 623.76 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0256 Tc 9.3 0 0 9.3 363.2555 623.76 Tm (0.05 )Tj EMC /Suspect <>BDC -0.0084 Tc 5.11 0 Td (0.34)Tj 0.372 0.376 0.365 rg 0 Tc 1.868 0 Td (\261)Tj 0.263 0.267 0.255 rg 0.0088 Tc 0.816 0 Td (0.04 )Tj EMC /Suspect <>BDC -0.0084 Tc 4.439 0.052 Td (0.37 )Tj EMC /Suspect <>BDC 0.05 Tc 9.4392 0 0 9.3 494.87 624.24 Tm (\2610.04 )Tj EMC ET BT /T1_3 1 Tf 0 Tc 13.8 0 0 13.8 94.12 608.41 Tm (s )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0256 Tc 9.3 0 0 9.3 125.66 608.41 Tm (0.37 )Tj EMC ET BT 0.372 0.376 0.365 rg /T1_0 1 Tf 0 Tc 9.3 0 0 9.3 143.0324 608.41 Tm (\261 )Tj ET BT /Suspect <>BDC 0.263 0.267 0.255 rg /T1_0 1 Tf 9.3 0 0 9.3 151.1048 608.41 Tm (0)Tj 0.372 0.376 0.365 rg 0.558 0 Td (.)Tj 0.263 0.267 0.255 rg -0.035 Tc 9.1584 0 0 9.3 157.83 608.41 Tm (03 )Tj EMC /Suspect <>BDC -0.0256 Tc 9.3 0 0 9.3 193.34 608.89 Tm (0.37 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.3 0 0 9.3 211.1867 608.89 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0256 Tc 9.3 0 0 9.3 218.7755 608.89 Tm (0.04 )Tj EMC /Suspect <>BDC 5.006 0 Td (0.38 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.3 0 0 9.3 283.178 608.89 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0084 Tc 9.3 0 0 9.3 290.7668 608.89 Tm (0.02 )Tj EMC /Suspect <>BDC -0.0256 Tc 5.058 0.051 Td (0.37 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.3 0 0 9.3 355.6529 609.3643 Tm (\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0256 Tc 9.3 0 0 9.3 363.2417 609.3643 Tm (0.03 )Tj EMC /Suspect <>BDC 0.05 Tc 9.3039 0 0 9.3 410.3 609.36 Tm (0.36\261 )Tj EMC /Suspect <>BDC -0.0256 Tc 9.3 0 0 9.3 435.74 609.36 Tm (0.03 )Tj EMC /Suspect <>BDC 0.05 Tc 9.8335 0 0 9.3 476.54 609.36 Tm (0.36\2610)Tj 0.372 0.376 0.365 rg 0 Tc 9.3 0 0 9.3 506.69 609.36 Tm (.)Tj 0.263 0.267 0.255 rg -0.035 Tc 9.1584 0 0 9.3 508.71 609.36 Tm (05 )Tj EMC ET BT /T1_1 1 Tf 0.0167 Tc 8.3 0 0 8.3 48.46 587.29 Tm (f: )Tj /T1_0 1 Tf 0.0164 Tc 8.8 0 0 8.8 55.1 587.29 Tm (frequency )Tj 0.05 Tc 9.4598 0 0 8.8 94.95 587.29 Tm (of )Tj 0.0177 Tc 8.8 0 0 8.8 105.13 587.29 Tm (breathing; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0028 Tc 13.6 0 0 13.6 145.9 587.29 Tm (n: )Tj EMC ET BT /T1_0 1 Tf 0.0105 Tc 8.8 0 0 8.8 161.69 587.29 Tm (inspiratory )Tj -0.0076 Tc 4.969 0 Td (time; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0187 Tc 13.6 0 0 13.6 227.98 587.29 Tm (nrr )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 7.4532 0 0 13.6 244.3 587.29 Tm (tot; )Tj 0.0051 Tc 8.8 0 0 8.8 258.65 587.76 Tm (inspiratory )Tj 0.0055 Tc 4.96 0 Td (fraction )Tj 0.05 Tc 10.0163 0 0 8.8 334.46 587.76 Tm (of )Tj -0.0088 Tc 8.8 0 0 8.8 347.02 587.76 Tm (the )Tj 0.0264 Tc 1.585 0 Td (breath )Tj 0.0074 Tc 2.88 0 Td (cycle; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0134 Tc 8.8 0 0 8.8 410.9256 587.76 Tm (NS: )Tj EMC ET BT /T1_0 1 Tf 0.0186 Tc 8.8 0 0 8.8 428.156 587.76 Tm (nonsmokers; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0197 Tc 8.8 0 0 8.8 477.9288 587.76 Tm (S: )Tj EMC ET BT /T1_0 1 Tf 0.0141 Tc 8.8 0 0 8.8 488.5328 587.76 Tm (smokers. )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 7.4899 0 0 6.6 84.79 560.41 Tm (Histarrine )Tj EMC /Suspect <>BDC 6.998 0 0 6.6 204.33 559.44 Tm (Methytcholine )Tj EMC ET BT /T1_0 1 Tf 0 Tc 7.4001 0 0 7.4001 62.31 552.24 Tm (6 )Tj 16.086 -0.128 Td (6 )Tj /T1_1 1 Tf 6.8001 0 0 6.8001 62.32 540.24 Tm (5 )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 6.8001 0 0 6.8001 181.8386 539.288 Tm (5 )Tj EMC /Suspect <>BDC 0.184 0.184 0.173 rg /T1_0 1 Tf 0.05 Tc 15.6797 0 0 7.3001 49.63 528.24 Tm (S4 )Tj EMC ET BT /T1_1 1 Tf 0 Tc 25.2001 0 0 25.2001 250.36 532.56 Tm (. )Tj ET BT /Suspect <>BDC 0.372 0.376 0.365 rg /T1_0 1 Tf -0.035 Tc 48.5954 0 0 52.2001 126.29 494.65 Tm (lj )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_0 1 Tf 0 Tc 7.3001 0 0 7.3001 181.89 527.76 Tm (4 )Tj ET BT /Suspect <>BDC 0.435 0.439 0.431 rg /T1_0 1 Tf -0.035 Tc 49.5482 0 0 69.3001 244.84 482.65 Tm (ll )Tj EMC /Suspect <>BDC 0.184 0.184 0.173 rg /C0_0 1 Tf 0 Tc 5.0401 0 0 5.76 49.44 517.68 Tm <003E007E0020>Tj EMC /Suspect <>BDC 0.263 0.267 0.255 rg /T1_3 1 Tf 7.1 0 0 7.1 62.33 517.68 Tm (3 )Tj EMC /Suspect <>BDC 16.834 -0.27 Td (3 )Tj EMC ET BT 0.106 0.11 0.098 rg /T1_4 1 Tf 10.9 0 0 10.9 48.94 509.53 Tm (w )Tj ET BT /Suspect <>BDC 0.263 0.267 0.255 rg /T1_0 1 Tf 7.2 0 0 7.2 62.36 505.21 Tm (2 )Tj EMC /Suspect <>BDC 0.184 0.184 0.173 rg /T1_1 1 Tf -0.0343 Tc 9.5 0 0 9.5 48.78 503.28 Tm (u. )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_0 1 Tf 0 Tc 6.9001 0 0 6.9001 181.4 504.25 Tm (2 )Tj 0.435 0.439 0.431 rg /T1_1 1 Tf 6.8001 0 0 6.8001 148.14 500.41 Tm (. )Tj ET BT /Suspect <>BDC 0.263 0.267 0.255 rg /T1_0 1 Tf 7.1 0 0 7.1 62.33 481.21 Tm (0 )Tj EMC /Suspect <>BDC 0.372 0.376 0.365 rg /T1_1 1 Tf 6.4001 0 0 6.4001 145.84 482.16 Tm (' )Tj EMC /Suspect <>BDC 0.263 0.267 0.255 rg 6.8001 0 0 6.8001 181.36 480.25 Tm (0 )Tj EMC /Suspect <>BDC 0.372 0.376 0.365 rg /C0_0 1 Tf 24.96 0 0 53.28 84.49 389.05 Tm <007E0020>Tj EMC /Suspect <>BDC 0.514 0.514 0.506 rg /T1_0 1 Tf 6.5001 0 0 6.5001 105.53 388.56 Tm (' )Tj EMC /Suspect <>BDC 0.263 0.267 0.255 rg 7.2 0 0 7.2 56.09 374.16 Tm (0)Tj 0.588 0.588 0.58 rg 0.589 0 Td (.)Tj 0.263 0.267 0.255 rg 0.208 0 Td (6 )Tj EMC /Suspect <>BDC 15.803 -0.132 Td (0)Tj 0.435 0.439 0.431 rg 0.589 0 Td (.)Tj 0.263 0.267 0.255 rg 0.142 0 Td (6 )Tj EMC /Suspect <>BDC 0.184 0.184 0.173 rg 0.05 Tc 19.5351 0 0 7.2 44.47 360.25 Tm (i0)Tj 0.372 0.376 0.365 rg 0 Tc 7.2 0 0 7.2 60.33 360.25 Tm (.)Tj 0.263 0.267 0.255 rg 0.207 0 Td (5 )Tj EMC /Suspect <>BDC 0.05 Tc 8.3108 0 0 7.2 175.11 361.69 Tm (0.5 )Tj EMC /Suspect <>BDC 0.184 0.184 0.173 rg /T1_1 1 Tf 6.1793 0 0 5.2 45.91 349.69 Tm (II\) )Tj EMC /Suspect <>BDC 0.263 0.267 0.255 rg /T1_0 1 Tf 7.9495 0 0 7.2 55.6 349.69 Tm (0.4 )Tj EMC /Suspect <>BDC 7.5881 0 0 7.2 175.6 350.16 Tm (0.4 )Tj EMC /Suspect <>BDC 7.8017 0 0 7.2 44.44 338.65 Tm (:::..0)Tj 0.435 0.439 0.431 rg 0 Tc 7.2 0 0 7.2 59.85 338.65 Tm (.)Tj 0.263 0.267 0.255 rg 0.276 0 Td (3 )Tj EMC /Suspect <>BDC 15.868 -0.068 Td (0)Tj 0.372 0.376 0.365 rg 0.522 0 Td (.)Tj 0.263 0.267 0.255 rg 0.21 0 Td (3 )Tj EMC /Suspect <>BDC 0.184 0.184 0.173 rg /T1_3 1 Tf 20.5 0 0 20.5 44.45 326.16 Tm (e )Tj EMC /Suspect <>BDC 0.263 0.267 0.255 rg /T1_0 1 Tf 7.2 0 0 7.2 55.61 326.16 Tm (0)Tj 0.435 0.439 0.431 rg 0.589 0 Td (.)Tj 0.263 0.267 0.255 rg 0.215 0 Td (2 )Tj EMC /Suspect <>BDC 15.863 0.068 Td (0)Tj 0.435 0.439 0.431 rg 0.589 0 Td (.)Tj 0.263 0.267 0.255 rg 0.215 0 Td (2 )Tj EMC /Suspect <>BDC 0.184 0.184 0.173 rg /T1_1 1 Tf -0.035 Tc 6.7658 0 0 13.8 46.4 322.81 Tm (,.. )Tj EMC ET BT /T1_1 1 Tf 0 Tc 11 0 0 11 44.46 314.65 Tm (> )Tj ET BT /Suspect <>BDC 0.263 0.267 0.255 rg /T1_0 1 Tf 7.2 0 0 7.2 56.09 314.65 Tm (0)Tj 0.372 0.376 0.365 rg 0.589 0 Td (.)Tj 0.263 0.267 0.255 rg 0.186 0 Td (1 )Tj EMC /Suspect <>BDC 15.892 0.065 Td (0)Tj 0.588 0.588 0.58 rg 0.589 0 Td (.)Tj 0.263 0.267 0.255 rg 0.253 0 Td (1 )Tj EMC /Suspect <>BDC /T1_1 1 Tf 7 0 0 7 61.36 302.65 Tm (0 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 7.2 0 0 7.2 180.89 303.12 Tm (0 )Tj EMC /Suspect <>BDC 0.05 Tc 6.3289 0 0 4.8001 87.3 297.37 Tm (Con)Tj 0.372 0.376 0.365 rg 0 Tc 4.8001 0 0 4.8001 98.84 297.37 Tm (l)Tj 0.263 0.267 0.255 rg -0.035 Tc 3.3397 0 0 4.8001 100.78 297.37 Tm (l'OC )Tj EMC /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 5.6424 0 0 5.5001 118.44 297.37 Tm (BronchOspasm )Tj EMC /Suspect <>BDC /T1_4 1 Tf 5.8053 0 0 5.2 206.34 297.84 Tm (Cont)Tj 0.372 0.376 0.365 rg 0 Tc 5.2 0 0 5.2 219.34 297.84 Tm (t)Tj 0.263 0.267 0.255 rg 0.05 Tc 5.962 0 0 5.2 220.74 297.84 Tm (ol )Tj EMC /Suspect <>BDC /C0_0 1 Tf 0 Tc 2.58 0 0 3.84 238.09 297.84 Tm <00420072006F006E0072003A007E0027004F007300700061007300740022006E0020>Tj EMC ET BT /T1_0 1 Tf 0.0049 Tc 8.2 0 0 8.2 46.53 283.44 Tm (Fig. )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 7.8667 0 0 7.8001 63.14 283.44 Tm (I. )Tj EMC ET BT /T1_0 1 Tf 0.0452 Tc 8.2 0 0 8.2 76.28 283.44 Tm (Mean )Tj 0.0058 Tc 3.046 0 Td (values )Tj 0.05 Tc 9.4567 0 0 8.2 127.09 283.44 Tm (\(\261so\) )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0304 Tc 8.2 0 0 8.2 154.05 283.44 Tm (FEV )Tj EMC /Suspect <>BDC 0 Tc 5.2 0 0 5.2 170.7 281.53 Tm (1)Tj 0.573 0.367 Td (, )Tj EMC /Suspect <>BDC -0.035 Tc 7.4397 0 0 9.9 180.47 283.44 Tm (VE )Tj EMC ET BT /T1_0 1 Tf 0.045 Tc 8.2 0 0 8.2 194.8 283.44 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0182 Tc 8.2 0 0 8.2 213.1024 283.44 Tm (VT{ft )Tj EMC ET BT 0.184 0.184 0.173 rg /T1_0 1 Tf -0.035 Tc 7.9356 0 0 8.2 238.02 283.44 Tm (in )Tj 0.263 0.267 0.255 rg 0.0292 Tc 8.2 0 0 8.2 249.04 283.44 Tm (control )Tj 0.021 Tc -24.761 -1.052 Td (conditions )Tj 0.05 Tc 8.4599 0 0 8.2 85.35 274.81 Tm (and )Tj -0.035 Tc 7.9356 0 0 8.2 102.66 274.81 Tm (in )Tj 0.0188 Tc 8.2 0 0 8.2 113.29 274.81 Tm (bronchospasm )Tj 0.0121 Tc 6.488 0 Td (induced )Tj 0.0047 Tc 3.756 0 Td (by )Tj 0.0071 Tc 1.518 0 Td (methylcholine )Tj 0.045 Tc 6.256 0 Td (and )Tj 0.0109 Tc -26.157 -1.112 Td (histamin)Tj 0.372 0.376 0.365 rg 0 Tc 3.502 0 Td (e )Tj 0.263 0.267 0.255 rg 0.0001 Tc 0.998 0 Td (in )Tj 0.0232 Tc 1.412 0 Td (nonsmoker)Tj 0.372 0.376 0.365 rg 0 Tc 4.552 0 Td (s )Tj 0.263 0.267 0.255 rg 0.0065 Tc 0.998 0 Td (\(open )Tj 0.372 0.376 0.365 rg 0 Tc 2.812 0 Td (c)Tj 0.263 0.267 0.255 rg 0.0135 Tc 0.468 0 Td (olumns\) )Tj 0.045 Tc 3.922 0 Td (and )Tj 0.0247 Tc 2.044 0 Td (smokers )Tj 0.029 Tc 3.983 0 Td (\(dotted )Tj 0.0039 Tc -24.759 -1.113 Td (columns\). )Tj ET BT /Suspect <>BDC 0.106 0.11 0.098 rg /T1_0 1 Tf 0 Tc 8.2 0 0 8.2 82.4252 256.565 Tm (\225 )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_0 1 Tf 0.0103 Tc 8.2 0 0 8.2 88.7146 256.565 Tm (different )Tj 0.184 0.184 0.173 rg -0.0102 Tc 3.862 0 Td (from )Tj 0.263 0.267 0.255 rg 0.0292 Tc 2.284 0 Td (control)Tj 0.435 0.439 0.431 rg 0 Tc (, )Tj ET BT /Suspect <>BDC 0.263 0.267 0.255 rg /T1_0 1 Tf 0.05 Tc 8.4436 0 0 8.2 169.45 256.56 Tm (p>BDC /T1_0 1 Tf -0.0234 Tc 10.2 0 0 10.2 96.4342 99.1236 Tm (ETV)Tj 0.372 0.376 0.365 rg 0 Tc 1.967 0 Td (, )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_0 1 Tf 0.0265 Tc 10.2 0 0 10.2 123.3622 99.1236 Tm (the )Tj 0.0284 Tc 1.686 0 Td (contribution )Tj 0.05 Tc 11.1292 0 0 10.2 198.13 99.12 Tm (of )Tj 0.0265 Tc 10.2 0 0 10.2 211.66 99.12 Tm (the )Tj 0.05 Tc 10.4371 0 0 10.2 229.39 99.12 Tm (RC )Tj -0.0217 Tc 10.2 0 0 10.2 248.62 99.12 Tm (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.2996 0 0 10.2 261.1 99.12 Tm (VT )Tj EMC /Suspect <>BDC /T1_1 1 Tf 0.0053 Tc 5.3001 0 0 5.3001 318.17 532.56 Tm (CONTROL )Tj EMC /Suspect <>BDC 0.0426 Tc 7.4001 0 0 7.4001 317.76 521.53 Tm (Vr )Tj EMC ET BT 0.184 0.184 0.173 rg /T1_1 1 Tf 0.05 Tc 7.5575 0 0 7.4001 329.63 521.53 Tm (\(ml\) )Tj ET BT /Suspect <>BDC 0.263 0.267 0.255 rg /T1_1 1 Tf -0.0098 Tc 5.3001 0 0 5.3001 299.41 446.16 Tm (BRONC)Tj 0.372 0.376 0.365 rg 0 Tc 3.53 0 Td (H)Tj 0.263 0.267 0.255 rg -0.016 Tc 0.734 0 Td (OSPASM )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.0053 Tc 8.2 0 0 8.2 312.46 437.05 Tm (Vr )Tj EMC ET BT /T1_0 1 Tf -0.0207 Tc 8.2 0 0 8.2 325.3422 437.05 Tm (\(ml\) )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0 Tc 5.3001 0 0 5.3001 381 560.41 Tm (NON )Tj EMC /Suspect <>BDC 0.0326 Tc 2.817 0 Td (SMOKERS )Tj EMC /Suspect <>BDC 0.05 Tc 5.3773 0 0 5.3001 473.21 560.41 Tm (SMOKERS )Tj EMC /Suspect <>BDC /T1_0 1 Tf 5.3955 0 0 5.1 349.74 541.21 Tm (12)Tj 0.372 0.376 0.365 rg 0 Tc 5.1 0 0 5.1 355.15 541.21 Tm (0)Tj 0.263 0.267 0.255 rg 0.565 0 Td (0 )Tj EMC /Suspect <>BDC 0.05 Tc 5.5212 0 0 5.1 352.22 520.09 Tm (800 )Tj EMC /Suspect <>BDC 5.7551 0 0 5.1 352.3 498.97 Tm (400 )Tj EMC /Suspect <>BDC /T1_5 1 Tf 0.0495 Tc 4.8001 0 0 4.8001 349.81 455.76 Tm (1200 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 5.5212 0 0 5.1 352.22 434.65 Tm (800 )Tj EMC /Suspect <>BDC /C0_0 1 Tf 0 Tc 5.28 0 0 5.76 358.08 390.97 Tm <006F002B002D>Tj 0.514 0.514 0.506 rg 6.624 0 0 5.76 373.93 390.97 Tm <002D002D007E002D002D>Tj 0.372 0.376 0.365 rg 11.04 0 0 5.76 407.05 390.97 Tm <007E007E>Tj 0.514 0.514 0.506 rg 12.48 0 0 5.76 429.13 390.97 Tm <007E0020>Tj EMC /Suspect <>BDC 0.435 0.439 0.431 rg 6.3086 0 0 5.76 446.4 390.97 Tm <002B002D002D002D007E002D002D>Tj 0.588 0.588 0.58 rg 5.5201 0 0 5.76 490.57 390.97 Tm <0072002D>Tj 0.263 0.267 0.255 rg 11.52 0 0 5.76 501.61 390.97 Tm <007E007E0020>Tj EMC /Suspect <>BDC 0.588 0.588 0.58 rg /T1_1 1 Tf 5.4001 0 0 5.4001 363.3 384.25 Tm (0 )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_0 1 Tf 5.1 0 0 5.1 427.62 384.25 Tm (6 )Tj /T1_1 1 Tf -0.0087 Tc 5.5001 0 0 5.5001 429.09 377.05 Tm (Time )Tj -0.035 Tc 5.2476 0 0 5.5001 442.95 377.05 Tm (\(Sec)Tj 0.372 0.376 0.365 rg 0 Tc 5.5001 0 0 5.5001 453.03 377.05 Tm (\) )Tj 0.263 0.267 0.255 rg /T1_0 1 Tf 0.0049 Tc 8.2 0 0 8.2 298.53 363.61 Tm (Fig. )Tj 0 Tc 1.871 0 Td (2)Tj 0.435 0.439 0.431 rg 0.571 0 Td (. )Tj 0.263 0.267 0.255 rg 0.0028 Tc 1.19 0 Td (Average )Tj 0.0235 Tc 3.909 0 Td (spirogram )Tj -0.0072 Tc 4.804 0 Td (for )Tj 0.0058 Tc 1.765 0 Td (the )Tj -0.0166 Tc 1.815 0 Td (two )Tj 0.033 Tc 2.052 0 Td (popul)Tj 0.372 0.376 0.365 rg 0 Tc 2.389 0 Td (a)Tj 0.263 0.267 0.255 rg 0.0124 Tc 0.534 0 Td (tions )Tj 0.011 Tc 2.505 0 Td (studied )Tj -0.035 Tc 7.9356 0 0 8.2 519.78 363.61 Tm (in )Tj 0.0292 Tc 8.2 0 0 8.2 298 354.49 Tm (control )Tj 0.0275 Tc 3.629 0 Td (conditions )Tj 0.045 Tc 5.034 0 Td (and )Tj 0.03 Tc 2.224 0 Td (during )Tj 0.0241 Tc 3.406 0 Td (bronchospasm)Tj 0.372 0.376 0.365 rg 0 Tc 6.124 0 Td (. )Tj 0.263 0.267 0.255 rg 0.0142 Tc 0.889 0 Td (Ordinate: )Tj 0.0107 Tc 4.632 0 Td (tidal )Tj 0.0105 Tc -25.932 -1.112 Td (volume )Tj 0.0001 Tc 3.448 0 Td (in )Tj -0.035 Tc 8.022 0 0 8.2 336.47 345.37 Tm (ml; )Tj 0.0023 Tc 8.2 0 0 8.2 350.32 345.37 Tm (abscissa)Tj 0.372 0.376 0.365 rg 0 Tc 3.321 0 Td (: )Tj 0.263 0.267 0.255 rg 0.0143 Tc 0.667 0 Td (time )Tj 0.0001 Tc 2.16 0 Td (in )Tj -0.0284 Tc 1.165 0 Td (s. )Tj 0.0332 Tc 1.063 0 Td (Dotted )Tj -0.0153 Tc 3.333 0 Td (line: )Tj 0.0065 Tc 2.173 0 Td (histamine; )Tj 0.0322 Tc 4.616 0 Td (dashed )Tj -0.0256 Tc -24.818 -1.055 Td (line)Tj 0.372 0.376 0.365 rg 0 Tc 1.446 0 Td (: )Tj 0.263 0.267 0.255 rg 0.0071 Tc 0.609 0 Td (mcthylcholine)Tj 0.435 0.439 0.431 rg 0 Tc 5.835 0 Td (. )Tj 0.263 0.267 0.255 rg 0.037 Tc 10.2 0 0 10.2 297.98 307.44 Tm (and )Tj 0.0253 Tc 2.267 0 Td (to )Tj 0.184 0.184 0.173 rg 0.05 Tc 10.7162 0 0 10.2 336.43 307.44 Tm (FRC )Tj 0.0013 Tc 10.2 0 0 10.2 364.22 307.44 Tm (did )Tj 0.263 0.267 0.255 rg 0.022 Tc 2.032 0 Td (not )Tj -0.01 Tc 1.968 0 Td (differ. )Tj 0.0317 Tc 3.154 0 Td (The )Tj 0.0298 Tc 2.258 0 Td (above )Tj 0.0057 Tc 3.153 0 Td (analysis )Tj 0.0144 Tc -19.004 -1.081 Td (therefore )Tj -0.001 Tc 4.465 0 Td (implies )Tj 0.05 Tc 10.215 0 0 10.2 381.58 296.41 Tm (that )Tj 0.0029 Tc 10.2 0 0 10.2 406.06 296.41 Tm (the )Tj 0.0078 Tc 1.976 0 Td (mechanical )Tj 0.0207 Tc 5.404 0 Td (conditions )Tj 0.0158 Tc -17.976 -1.082 Td (associated )Tj 0.0056 Tc 4.668 0 Td (with )Tj 0.0236 Tc 2.261 0 Td (bronchospasm )Tj -0.0181 Tc 6.445 0 Td (were )Tj 0.0029 Tc 2.352 0 Td (the )Tj 0.0146 Tc 1.635 0 Td (same )Tj -0.0079 Tc 2.5 0 Td (in )Tj 0.0029 Tc 1.229 0 Td (the )Tj 0.0046 Tc -21.082 -1.035 Td (two )Tj 0.0327 Tc 1.875 0 Td (groups)Tj 0.372 0.376 0.365 rg 0 Tc 2.911 0 Td (, )Tj 0.263 0.267 0.255 rg -0.0044 Tc 0.617 0 Td (for )Tj 0.0383 Tc 1.565 0 Td (both )Tj 0.0151 Tc 2.257 0 Td (histamine )Tj 0.05 Tc 10.3398 0 0 10.2 436.21 274.81 Tm (and )Tj 0.0049 Tc 10.2 0 0 10.2 455.98 274.81 Tm (methylcholine. )Tj 0.184 0.184 0.173 rg 0.05 Tc 10.2656 0 0 10.2 307.59 263.76 Tm (The )Tj 0.263 0.267 0.255 rg 0.0241 Tc 10.2 0 0 10.2 326.78 263.76 Tm (concentrations )Tj 0.05 Tc 11.1292 0 0 10.2 392.05 263.76 Tm (of )Tj 0.0092 Tc 10.2 0 0 10.2 404.15 263.76 Tm (histamine )Tj 0.037 Tc 4.226 0 Td (and )Tj 0.0105 Tc 1.843 0 Td (methylcholine )Tj -0.0144 Tc -16.469 -1.081 Td (used )Tj -0.0079 Tc 2.11 0 Td (in )Tj 0.0244 Tc 0.985 0 Td (each )Tj 0.0111 Tc 2.162 0 Td (subject )Tj 0.0013 Tc 3.11 0 Td (did )Tj 0.0455 Tc 1.609 0 Td (not )Tj 0.0004 Tc 1.591 0 Td (differ )Tj 0.0048 Tc 2.493 0 Td (from )Tj 0.0087 Tc 2.259 0 Td (each )Tj 0.0235 Tc 2.119 0 Td (other. )Tj 0.0359 Tc 2.683 0 Td (To )Tj 0.0125 Tc -21.13 -1.082 Td (avoid )Tj 0.0006 Tc 2.691 0 Td (non-specific )Tj 0.05 Tc 10.6414 0 0 10.2 378.74 241.69 Tm (pH )Tj -0.0175 Tc 10.2 0 0 10.2 395.41 241.69 Tm (effect )Tj 0.05 Tc 10.2564 0 0 10.2 421.34 241.69 Tm (on )Tj -0.035 Tc 9.9712 0 0 10.2 435.74 241.69 Tm (ai)Tj 0.106 0.11 0.098 rg 0 Tc 10.2 0 0 10.2 443.51 241.69 Tm (r)Tj 0.263 0.267 0.255 rg -0.0067 Tc 0.376 0 Td (way )Tj 0.184 0.184 0.173 rg 0.013 Tc 2.024 0 Td (receptors)Tj 0.372 0.376 0.365 rg 0 Tc 3.797 0 Td (, )Tj 0.263 0.267 0.255 rg 0.0265 Tc 0.578 0 Td (the )Tj 0.035 Tc -21.09 -1.082 Td (drugs )Tj -0.0181 Tc 2.644 0 Td (were )Tj 0.184 0.184 0.173 rg 0.0176 Tc 2.156 0 Td (diluted )Tj 0.263 0.267 0.255 rg -0.0079 Tc 3.202 0 Td (in )Tj 0.0018 Tc 1.044 0 Td (buffered )Tj 0.0004 Tc 3.703 0 Td (saline )Tj -0.0349 Tc 2.577 0 Td ([15]. )Tj 0.0058 Tc 2.076 0 Td (Some )Tj 0.05 Tc 11.1292 0 0 10.2 501.01 230.65 Tm (of )Tj 0.0029 Tc 10.2 0 0 10.2 513.1 230.65 Tm (the )Tj 0.0078 Tc -21.094 -1.082 Td (subjects )Tj 0.0089 Tc 3.532 0 Td (experienced )Tj 0.184 0.184 0.173 rg -0.0126 Tc 5.224 0 Td (flushes, )Tj 0.0211 Tc 3.398 0 Td (headache )Tj 0.263 0.267 0.255 rg 0.037 Tc 4.179 0 Td (and )Tj 0.0029 Tc 1.89 0 Td (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0045 Tc 10.2 0 0 10.2 500.0134 219.6136 Tm (sensa\255)Tj EMC ET BT /T1_0 1 Tf 0.0161 Tc 10.2 0 0 10.2 298.0534 209.0566 Tm (tion )Tj 0.05 Tc 10.5727 0 0 10.2 319.58 209.05 Tm (of )Tj 0.0196 Tc 10.2 0 0 10.2 333.1 209.05 Tm (tracheal )Tj 0.0166 Tc 3.815 0 Td (burning )Tj 0.0279 Tc 3.66 0 Td (after )Tj 0.106 0.11 0.098 rg -0.0202 Tc 2.409 0 Td (hi)Tj 0.263 0.267 0.255 rg 0.0199 Tc 0.787 0 Td (stamine )Tj 0.184 0.184 0.173 rg 0.0196 Tc 3.724 0 Td (inhalation. )Tj 0.014 Tc -17.879 -1.082 Td (However, )Tj 0.263 0.267 0.255 rg 0.0265 Tc 4.803 0 Td (the )Tj 0.0018 Tc 2.012 0 Td (systemic )Tj -0.0088 Tc 4.191 0 Td (effects )Tj 0.0315 Tc 3.354 0 Td (probably )Tj 0.0248 Tc 4.506 0 Td (did )Tj 0.184 0.184 0.173 rg 0.022 Tc 2.126 0 Td (not )Tj 0.263 0.267 0.255 rg -0.0037 Tc -20.948 -1.082 Td (influence )Tj 0.0265 Tc 4.006 0 Td (the )Tj 0.0086 Tc 1.554 0 Td (results, )Tj -0.0126 Tc 3.281 0 Td (since )Tj 0.0098 Tc 2.309 0 Td (earlier )Tj 0.0123 Tc 2.915 0 Td (studies )Tj -0.0013 Tc 3.153 0 Td (suggest )Tj -0.0078 Tc 3.353 0 Td (they )Tj 0.0443 Tc -20.62 -1.082 Td (do )Tj 0.05 Tc 10.4827 0 0 10.2 311.99 175.93 Tm (not )Tj -0.0004 Tc 10.2 0 0 10.2 329.66 175.93 Tm (affect )Tj 0.0265 Tc 2.643 0 Td (the )Tj 0.0336 Tc 1.545 0 Td (control )Tj 0.05 Tc 11.1292 0 0 10.2 406.93 175.93 Tm (of )Tj 0.0298 Tc 10.2 0 0 10.2 419.53 175.93 Tm (breath)Tj 0.106 0.11 0.098 rg 0 Tc 2.674 0 Td (i)Tj 0.263 0.267 0.255 rg -0.0085 Tc 0.289 0 Td (ng )Tj 0 Tc 1.341 0 Td ([)Tj 0.106 0.11 0.098 rg 0.32 0 Td (1)Tj 0.263 0.267 0.255 rg -0.035 Tc 9.7127 0 0 10.2 471.24 175.93 Tm (6]. )Tj 0.0211 Tc 10.2 0 0 10.2 307.66 164.89 Tm (Arterial )Tj 0.0314 Tc 3.863 0 Td (partial )Tj 0.0068 Tc 3.341 0 Td (pressures )Tj 0.05 Tc 11.1292 0 0 10.2 425.65 164.89 Tm (of )Tj 0.0084 Tc 10.2 0 0 10.2 440.06 164.89 Tm (oxygen )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0388 Tc 10.2 0 0 10.2 476.525 164.89 Tm (\(Pao)Tj 0 Tc 6.5001 0 0 6.5001 496.76 162.49 Tm (2)Tj 0.591 0.369 Td (\) )Tj EMC ET BT /T1_0 1 Tf 0.037 Tc 10.2 0 0 10.2 509.66 164.89 Tm (and )Tj 0.0343 Tc -20.8 -1.082 Td (carbon )Tj 0.0118 Tc 3.294 0 Td (dioxide )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0477 Tc 10.2 0 0 10.2 366.5948 153.8536 Tm (\(Paco)Tj /T1_1 1 Tf 0 Tc 6.3001 0 0 6.3001 392.11 151.44 Tm (2)Tj 0.6 0.383 Td (\) )Tj EMC ET BT /T1_0 1 Tf -0.0181 Tc 10.2 0 0 10.2 403.67 153.85 Tm (were )Tj 0.0455 Tc 2.306 0 Td (not )Tj 0.184 0.184 0.173 rg 0.0143 Tc 1.787 0 Td (measured. )Tj 0.0324 Tc 4.61 0 Td (We )Tj 0.263 0.267 0.255 rg 0.0229 Tc 1.782 0 Td (can )Tj -0.0014 Tc -20.898 -1.083 Td (safely )Tj 0.0164 Tc 2.686 0 Td (assume )Tj -0.0078 Tc 3.443 0 Td (they )Tj -0.0024 Tc 2.025 0 Td (were )Tj 0.0449 Tc 2.259 0 Td (norma)Tj 0.106 0.11 0.098 rg 0 Tc 2.769 0 Td (l )Tj 0.184 0.184 0.173 rg -0.0079 Tc 0.566 0 Td (in )Tj 0.0018 Tc 1.183 0 Td (resting )Tj 0.263 0.267 0.255 rg 0.0335 Tc 3.05 0 Td (cond)Tj 0.106 0.11 0.098 rg 0 Tc 2.073 0 Td (i)Tj 0.263 0.267 0.255 rg 0.009 Tc 0.288 0 Td (tions )Tj 0.184 0.184 0.173 rg 0.05 Tc 10.9413 0 0 10.2 298.03 132.25 Tm (Band )Tj ET BT /Suspect <>BDC 0.263 0.267 0.255 rg /T1_1 1 Tf -0.012 Tc 9.5 0 0 9.5 325.3 132.25 Tm (C. )Tj EMC ET BT 0.184 0.184 0.173 rg /T1_0 1 Tf 0.0393 Tc 10.2 0 0 10.2 338.35 132.25 Tm (During )Tj 0.263 0.267 0.255 rg 0.0243 Tc 3.3 0 Td (bronchospasm, )Tj ET BT /Suspect <>BDC 0.184 0.184 0.173 rg /T1_0 1 Tf 0.05 Tc 10.6325 0 0 10.2 439.15 132.25 Tm (Paco)Tj 0 Tc 6.5001 0 0 6.5001 461.72 129.85 Tm (2 )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_0 1 Tf 0.0017 Tc 10.2 0 0 10.2 468.47 132.25 Tm (was )Tj 0.0248 Tc 1.838 0 Td (probably )Tj 0.0276 Tc -18.591 -1.083 Td (normal )Tj 0.05 Tc 10.5727 0 0 10.2 332.06 121.2 Tm (or )Tj 0.184 0.184 0.173 rg -0.0132 Tc 10.2 0 0 10.2 345.03 121.2 Tm (low, )Tj 0.263 0.267 0.255 rg -0.0008 Tc 2.066 0 Td (since )Tj 0.106 0.11 0.098 rg -0.0079 Tc 2.406 0 Td (in)Tj 0.263 0.267 0.255 rg 0.0063 Tc 0.798 0 Td (creased )Tj ET BT /Suspect <>BDC 0.184 0.184 0.173 rg /T1_0 1 Tf 0.05 Tc 10.4014 0 0 10.2 433.87 121.2 Tm (Paco)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 455.95 118.8 Tm (2 )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_0 1 Tf -0.035 Tc 10.1489 0 0 10.2 463.6 121.2 Tm (is )Tj -0.0029 Tc 10.2 0 0 10.2 473.62 121.2 Tm (seen )Tj 0.0105 Tc 2.122 0 Td (only )Tj -0.035 Tc 9.9195 0 0 10.2 517.36 121.2 Tm (in )Tj -0.0063 Tc 10.2 0 0 10.2 297.46 110.16 Tm (severe )Tj 0.0388 Tc 2.78 0 Td (asthma )Tj 0.0056 Tc 3.35 0 Td (with )Tj 0.0052 Tc 2.108 0 Td (fatigue )Tj 0.05 Tc 11.6856 0 0 10.2 412.69 110.16 Tm (of )Tj 0.0029 Tc 10.2 0 0 10.2 424.78 110.16 Tm (the )Tj 0.106 0.11 0.098 rg 0 Tc 1.554 0 Td (r)Tj 0.263 0.267 0.255 rg 0.0289 Tc 0.32 0 Td (espiratory )Tj -0.004 Tc 4.526 0 Td (muscles, )Tj 0.184 0.184 0.173 rg 0.0024 Tc -18.87 -1.082 Td (which )Tj 0.263 0.267 0.255 rg 0.0156 Tc 2.909 0 Td (obviously )Tj 0.0248 Tc 4.518 0 Td (did )Tj 0.0455 Tc 1.844 0 Td (not )Tj 0.0268 Tc 1.826 0 Td (occur )Tj 0.0391 Tc 2.731 0 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/C0_0 1 Tf 0 Tc 4.3201 0 0 4.8 96 732.73 Tm <004E0051004E>Tj 0.396 0.396 0.388 rg 1.92 0 0 4.8 109.44 732.73 Tm <00B7>Tj 0.259 0.259 0.251 rg 4.3201 0 0 4.8 111.36 732.73 Tm <0053004D0051007E0045005200530020>Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg /T1_0 1 Tf 7.4001 0 0 7.4001 170.76 732.73 Tm (\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg /C0_0 1 Tf 4.8 0 0 3.84 96 694.8 Tm <0048>Tj 0.396 0.396 0.388 rg 1.44 0 0 3.84 100.81 694.8 Tm <0049>Tj 0.259 0.259 0.251 rg 21.6 0 0 3.84 102.24 694.8 Tm <007E0020>Tj EMC /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 6.9212 0 0 5.7 95.93 689.05 Tm (ns8 )Tj EMC ET BT /T1_1 1 Tf 0 Tc 5.7 0 0 5.7 142.5 689.05 Tm (0 )Tj 0.326 0.326 0.318 rg /T1_3 1 Tf 6.3001 0 0 6.3001 95.97 684.24 Tm (r )Tj ET BT /Suspect <>BDC 0.396 0.396 0.388 rg /T1_0 1 Tf 0.05 Tc 9.5946 0 0 8.3 99.64 684.24 Tm (.a)Tj 0.259 0.259 0.251 rg -0.035 Tc 8.0843 0 0 8.3 106.95 684.24 Tm (ea )Tj EMC /Suspect <>BDC /T1_4 1 Tf 0.05 Tc 6.2737 0 0 6.1 95.94 678.97 Tm (n<0005 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0 Tc 12.3 0 0 12.3 159.16 667.44 Tm (\225 )Tj EMC /Suspect <>BDC 0.326 0.326 0.318 rg 4.4001 0 0 4.4001 169.88 664.09 Tm (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 12.3 0 0 12.3 165.4 635.76 Tm (\225 )Tj EMC /Suspect <>BDC -2.185 -0.624 Td (\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 4.7 0 0 4.7 158.35 624.24 Tm (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 0.05 Tc 13.3618 0 0 5.1 115.47 599.29 Tm (\225\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 0 Tc 5.1 0 0 5.1 130.51 599.29 Tm (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 4.7 0 0 4.7 142.01 590.17 Tm (\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 1.945 0 Td (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg /T1_2 1 Tf 9.1 0 0 9.1 101.51 567.61 Tm (I )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 1.367 0 Td (1)Tj 6.8001 0 0 6.8001 115.15 572.89 Tm (2 )Tj EMC /Suspect <>BDC 0.769 -0.776 Td (\225 )Tj EMC ET BT /T1_2 1 Tf 9.1 0 0 9.1 126.47 567.61 Tm (I )Tj ET BT /Suspect <>BDC 0.165 0.165 0.157 rg /T1_2 1 Tf 9.1 0 0 9.1 138.9461 567.61 Tm (I )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 1.371 0 Td (I )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 1.424 0 Td (I )Tj EMC /Suspect <>BDC 0.326 0.326 0.318 rg 6.8001 0 0 6.8001 176.93 567.61 Tm (I )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg /T1_0 1 Tf 6.1 0 0 6.1 100.26 562.33 Tm (0 )Tj EMC /Suspect <>BDC 4.4001 0 0 4.4001 114.2 559.92 Tm (0 )Tj EMC /Suspect <>BDC 0.396 0.396 0.388 rg 5.9001 0 0 5.9001 122.76 562.33 Tm (\267)Tj 0.259 0.259 0.251 rg -0.003 Tc 0.32 0 Td (:20 )Tj EMC /Suspect <>BDC 0.326 0.326 0.318 rg 0.05 Tc 6.6086 0 0 6.1 134.74 562.33 Tm (\26730 )Tj EMC /Suspect <>BDC 0.482 0.482 0.478 rg 0 Tc 6.1 0 0 6.1 147.72 562.33 Tm (\267)Tj 0.259 0.259 0.251 rg 0.05 Tc 6.4947 0 0 6.1 150.21 562.33 Tm (40 )Tj EMC /Suspect <>BDC 0.0048 Tc 6.1 0 0 6.1 160.68 562.33 Tm (\267SO )Tj EMC /Suspect <>BDC 0.326 0.326 0.318 rg 0.05 Tc 7.3429 0 0 6.1 173.13 562.33 Tm (\26760 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg /T1_2 1 Tf 5.8859 0 0 5.5001 101.62 546.97 Tm (FEV1 )Tj EMC /Suspect <>BDC -0.0001 Tc 5.5001 0 0 5.5001 126.63 546.97 Tm (\(,., )Tj EMC ET BT 0.326 0.326 0.318 rg /T1_2 1 Tf 0.05 Tc 6.6825 0 0 5.4001 134.82 546.97 Tm (of )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 5.8933 0 0 5.4001 142.02 546.97 Tm (conlroll )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg /T1_0 1 Tf 0.0358 Tc 5.6 0 0 5.6 97.9 510.49 Tm (Mtlhylr;hoiO'w )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.9324 0 0 8.3 97.43 504.72 Tm (n.e )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 7.5809 0 0 5.8001 97.43 499.93 Tm (ro069 )Tj EMC /Suspect <>BDC 6.4193 0 0 5.8001 97.45 495.12 Tm (po0.05 )Tj EMC /Suspect <>BDC /T1_2 1 Tf 8.5867 0 0 5.1 97.24 486.97 Tm (Hsl....\255)Tj EMC ET BT /T1_0 1 Tf 0.0413 Tc 8.3 0 0 8.3 96.95 481.21 Tm (n.e )Tj ET BT /Suspect <>BDC /T1_5 1 Tf 0.05 Tc 6.8544 0 0 5.7 96.83 475.93 Tm (r\225069 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 96.97 471.61 Tm (p)Tj 0.396 0.396 0.388 rg 0.499 0 Td (.)Tj 0.259 0.259 0.251 rg -0.035 Tc 7.611 0 0 8.3 103.13 471.61 Tm (o.os )Tj ET BT /Suspect <>BDC 0.165 0.165 0.157 rg /T1_0 1 Tf 0 Tc 12.3 0 0 12.3 121.72 399.61 Tm (\225 )Tj EMC /Suspect <>BDC -0.546 -1.405 Td (\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 4.4001 0 0 4.4001 113.72 370.33 Tm (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 12.3 0 0 12.3 137.56 411.12 Tm (\225 )Tj EMC /Suspect <>BDC /T1_2 1 Tf 11.2 0 0 11.2 171.19 490.33 Tm (\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg /T1_0 1 Tf 5.1 0 0 5.1 142.03 483.61 Tm (0 )Tj EMC /Suspect <>BDC /T1_2 1 Tf 3.8001 0 0 3.8001 173.72 457.69 Tm (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg /T1_0 1 Tf 5.1 0 0 5.1 158.8 448.56 Tm (\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 2.076 0 Td (0 )Tj EMC /Suspect <>BDC 4.4001 0 0 4.4001 157.88 416.41 Tm (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg /T1_2 1 Tf 11.2 0 0 11.2 164.95 406.33 Tm (\225 )Tj EMC /Suspect <>BDC 8.8 0 0 8.8 101.04 363.12 Tm (I )Tj EMC /Suspect <>BDC 1.418 0 Td (I )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg -0.035 Tc 4.3628 0 0 9.1 151.08 363.12 Tm (I> )Tj EMC /Suspect <>BDC 0 Tc 8.8 0 0 8.8 163.92 363.12 Tm (I )Tj EMC /Suspect <>BDC 1.418 0 Td (I )Tj EMC /Suspect <>BDC /T1_0 1 Tf 6.1 0 0 6.1 99.78 358.33 Tm (0 )Tj EMC /Suspect <>BDC 0.0258 Tc 1.564 0 Td (\26710 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg -0.0067 Tc 5.9001 0 0 5.9001 123.24 358.33 Tm (\267:20 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 0.05 Tc 6.6086 0 0 6.1 135.7 358.33 Tm (\26730 )Tj EMC /Suspect <>BDC 0.0048 Tc 6.1 0 0 6.1 160.68 358.33 Tm (\267SO )Tj EMC /Suspect <>BDC 0.05 Tc 6.4727 0 0 6.4001 172.73 358.33 Tm (-60 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 0 Tc 5.4001 0 0 5.4001 118.96 353.53 Tm (\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 1.872 0 Td (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg /T1_2 1 Tf 11.2 0 0 11.2 141.91 340.56 Tm (\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg /T1_0 1 Tf 4.7 0 0 4.7 113.71 330.97 Tm (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 12.3 0 0 12.3 212.92 669.36 Tm (\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg /T1_2 1 Tf 3.8001 0 0 3.8001 216.44 662.17 Tm (0 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 5.1 0 0 5.1 225.07 625.21 Tm (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 12.3 0 0 12.3 215.8 618 Tm (\225 )Tj EMC /Suspect <>BDC 1.249 0 Td (\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 4.4001 0 0 4.4001 227.96 595.44 Tm (0 )Tj EMC /Suspect <>BDC 5.1 0 0 5.1 231.79 590.17 Tm (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 12.3 0 0 12.3 230.2 581.05 Tm (\225 )Tj EMC /Suspect <>BDC 0.05 Tc 6.3952 0 0 5.6 244.29 730.8 Tm (Mtthylcl'dine )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 6.8585 0 0 5.7 244.31 725.05 Tm (no? )Tj EMC ET BT /T1_3 1 Tf 0 Tc 6.3001 0 0 6.3001 244.29 719.76 Tm (r )Tj ET BT /Suspect <>BDC 0.165 0.165 0.157 rg /T1_0 1 Tf 0.05 Tc 7.7528 0 0 5.8001 248.48 719.76 Tm (\267025 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 7.2217 0 0 5.8001 244.33 714.97 Tm (p.0591 )Tj EMC /Suspect <>BDC 0.326 0.326 0.318 rg /T1_5 1 Tf 5.8429 0 0 5.5001 243.72 706.8 Tm (Hlslarrinr )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg /T1_1 1 Tf 6.5317 0 0 5.5001 244.26 701.05 Tm (n:7 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 6.5409 0 0 5.8001 243.74 695.76 Tm (\225\2670.16 )Tj EMC /Suspect <>BDC 6.7248 0 0 5.7 243.81 690.48 Tm (P\2250727 )Tj EMC /Suspect <>BDC 0 Tc 12.3 0 0 12.3 252.28 663.61 Tm (\225 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 0.351 -2.498 Td (\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 5.1 0 0 5.1 242.83 601.21 Tm (0 )Tj EMC /Suspect <>BDC 4.7 0 0 4.7 273.07 637.21 Tm (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 5.4001 0 0 5.4001 259.12 592.56 Tm (\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 2.317 0 Td (0 )Tj EMC /Suspect <>BDC 0.326 0.326 0.318 rg /T1_2 1 Tf 8.8 0 0 8.8 201.84 567.12 Tm (I )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 1.418 0 Td (I )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 1.418 0 Td (I )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 1.418 0 Td (I )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 1.418 0 Td (I )Tj EMC /Suspect <>BDC 1.418 0 Td (I )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 1.418 0 Td (I )Tj EMC /Suspect <>BDC /T1_0 1 Tf 6.1 0 0 6.1 201.06 561.85 Tm (0 )Tj EMC /Suspect <>BDC 0.326 0.326 0.318 rg 0.0258 Tc 1.643 0 Td (\26710 )Tj EMC /Suspect <>BDC 0.396 0.396 0.388 rg 0 Tc 5.9001 0 0 5.9001 223.56 561.85 Tm (\267)Tj 0.259 0.259 0.251 rg -0.003 Tc 0.32 0 Td (:20 )Tj EMC /Suspect <>BDC 0.05 Tc 6.9757 0 0 6.1 236.5 561.85 Tm (\26730 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 6.1467 0 0 6.1 248.57 561.85 Tm (-4)Tj 0.326 0.326 0.318 rg 0 Tc 6.1 0 0 6.1 253.86 561.85 Tm (0 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 0.0048 Tc 1.17 0 Td (\267SO )Tj EMC /Suspect <>BDC 0.05 Tc 7.3429 0 0 6.1 272.97 561.85 Tm (\26760 )Tj EMC /Suspect <>BDC 0.326 0.326 0.318 rg /T1_2 1 Tf 6.3845 0 0 5.5001 201.93 546.97 Tm (FEVt )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0 Tc 5.6 0 0 5.6 226.98 546.97 Tm (\()Tj 0.165 0.165 0.157 rg -0.035 Tc 3.755 0 0 5.6 229.4 546.97 Tm ('JI. )Tj EMC ET BT 0.259 0.259 0.251 rg /T1_2 1 Tf 0.05 Tc 6.6825 0 0 5.4001 235.14 546.97 Tm (of )Tj 5.8883 0 0 5.4001 241.86 546.97 Tm (control\) )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 4.4001 0 0 4.4001 216.44 447.12 Tm (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg /T1_2 1 Tf 11.2 0 0 11.2 212.95 415.93 Tm (\225 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 12.3 0 0 12.3 231.16 415.93 Tm (\225 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 5.1 0 0 5.1 225.55 412.09 Tm (0 )Tj EMC /Suspect <>BDC 12.3 0 0 12.3 215.8 399.61 Tm (\225 )Tj EMC /Suspect <>BDC 0.05 Tc 6.4562 0 0 5.5001 239.97 522 Tm (Methylcho\(N )Tj EMC ET BT /T1_0 1 Tf 8.5602 0 0 5.7 239.99 516.73 Tm (n.? )Tj ET BT /Suspect <>BDC /T1_4 1 Tf 0 Tc 3.9001 0 0 3.9001 239.46 511.92 Tm (I )Tj EMC /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 6.7103 0 0 5.8001 244.25 511.92 Tm (e032 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 7.8748 0 0 6.1 240.01 507.12 Tm (p.0)Tj 0.482 0.482 0.478 rg 0 Tc 6.1 0 0 6.1 249.96 507.12 Tm (.)Tj 0.259 0.259 0.251 rg 0.05 Tc 6.6638 0 0 6.1 251.01 507.12 Tm (475 )Tj EMC /Suspect <>BDC /T1_5 1 Tf -0.035 Tc 4.306 0 0 5.4001 239.91 496.09 Tm (Hist.Cif"r"4nct )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 5.9233 0 0 5.7 239.99 490.33 Tm (no? )Tj EMC /Suspect <>BDC /T1_2 1 Tf 0.0317 Tc 5.7 0 0 5.7 239.89 485.53 Tm (r.OIJ7 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 6.801 0 0 5.8001 240.49 480.72 Tm (p.0)Tj 0.482 0.482 0.478 rg 0 Tc 5.8001 0 0 5.8001 249 480.72 Tm (.)Tj 0.259 0.259 0.251 rg 0.05 Tc 7.0548 0 0 5.8001 250.44 480.72 Tm (896 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 0 Tc 12.3 0 0 12.3 251.8 416.41 Tm (\225 )Tj EMC ET BT 0.259 0.259 0.251 rg /T1_2 1 Tf -0.035 Tc 13.4006 0 0 30.5 255.96 405.37 Tm (.. )Tj ET BT /Suspect <>BDC 0.165 0.165 0.157 rg /T1_0 1 Tf 0 Tc 4.4001 0 0 4.4001 273.08 445.69 Tm (0 )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg -0.327 -4.582 Td (0 )Tj EMC /Suspect <>BDC 5.4001 0 0 5.4001 232.27 390 Tm (0 )Tj EMC /Suspect <>BDC 1.956 0 Td (0 )Tj EMC /Suspect <>BDC 4.4001 0 0 4.4001 227.96 381.37 Tm (0 )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg /T1_2 1 Tf 11.2 0 0 11.2 229.75 371.28 Tm (\225 )Tj EMC /Suspect <>BDC 0.396 0.396 0.388 rg 9.1 0 0 9.1 201.35 362.65 Tm (I )Tj EMC /Suspect <>BDC 0.326 0.326 0.318 rg 1.371 0 Td (I )Tj EMC /Suspect <>BDC 0.165 0.165 0.157 rg 1.371 0 Td (I )Tj EMC /Suspect <>BDC 0.326 0.326 0.318 rg 1.371 0 Td (I )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 1.424 0 Td (I )Tj EMC /Suspect <>BDC 0.326 0.326 0.318 rg 1.371 0 Td (I )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg 1.371 0 Td (I )Tj EMC ET BT 0.396 0.396 0.388 rg /T1_0 1 Tf 8.3 0 0 8.3 200.08 357.84 Tm (o )Tj ET BT /Suspect <>BDC 0.482 0.482 0.478 rg /T1_0 1 Tf -0.035 Tc 5.9083 0 0 6.1 211.56 357.84 Tm (\26710 )Tj EMC /Suspect <>BDC 0.0205 Tc 5.9001 0 0 5.9001 223.08 357.84 Tm (\267:10 )Tj EMC /Suspect <>BDC 0.553 0.557 0.541 rg 0 Tc 6.1 0 0 6.1 236.04 357.84 Tm (\267)Tj 0.326 0.326 0.318 rg -0.035 Tc 5.4497 0 0 6.1 238.02 357.84 Tm (3:> )Tj EMC /Suspect <>BDC 0.396 0.396 0.388 rg 0.05 Tc 6.9757 0 0 6.1 248.02 357.84 Tm (\26740 )Tj EMC /Suspect <>BDC 0.482 0.482 0.478 rg 0.0048 Tc 6.1 0 0 6.1 261 357.84 Tm (\267SO )Tj EMC /Suspect <>BDC 0.616 0.62 0.604 rg 0 Tc 1.967 0 Td (\267)Tj 0.326 0.326 0.318 rg 0.05 Tc 6.5345 0 0 6.1 275.45 357.84 Tm (00 )Tj EMC ET BT /T1_0 1 Tf -0.0207 Tc 8.3 0 0 8.3 60.92 314.65 Tm (Fig. )Tj -0.035 Tc 7.7865 0 0 8.3 76.23 314.65 Tm (3. )Tj 0.259 0.259 0.251 rg 0.0049 Tc 8.3 0 0 8.3 90.68 314.65 Tm (Relationships )Tj -0.0037 Tc 5.963 0 Td (between )Tj 0.0068 Tc 3.69 0 Td (changes )Tj 0.326 0.326 0.318 rg -0.035 Tc 7.9356 0 0 8.3 201.54 314.65 Tm (in )Tj 0.259 0.259 0.251 rg 0.0188 Tc 8.3 0 0 8.3 211.16 314.65 Tm (FEV )Tj 0.326 0.326 0.318 rg 0 Tc 4.8001 0 0 4.8001 227.84 313.21 Tm (1 )Tj 0.0358 Tc 8.3 0 0 8.3 234.16 314.65 Tm (and )Tj 0.259 0.259 0.251 rg 0.0164 Tc 1.908 0 Td (changes )Tj -0.035 Tc 7.9356 0 0 8.3 280.74 314.65 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 7.0677 0 0 9.6 60.47 306 Tm (VE )Tj EMC ET BT 0.396 0.396 0.388 rg /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 74.3 306 Tm (\()Tj 0.259 0.259 0.251 rg 0.0095 Tc 0.359 0 Td (upper )Tj -0.0087 Tc 2.951 0 Td (panels\), )Tj 0.0358 Tc 3.69 0 Td (and )Tj 0.326 0.326 0.318 rg -0.009 Tc 2.141 0 Td (in )Tj 0.165 0.165 0.157 rg -0.035 Tc 7.8117 0 0 8.3 161.26 306 Tm (VT)Tj 0.326 0.326 0.318 rg -0.003 Tc 8.3 0 0 8.3 170.88 306 Tm (/TI )Tj 0.259 0.259 0.251 rg 0.0252 Tc 1.781 0 Td (\(bottom )Tj 0.0026 Tc 3.946 0 Td (panels\) )Tj -0.004 Tc 3.518 0 Td (induced )Tj -0.035 Tc 8.0386 0 0 8.3 279.37 306 Tm (by )Tj 0.0061 Tc 8.3 0 0 8.3 59.98 296.89 Tm (methylcholine )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.3 0 0 8.3 110.776 296.89 Tm (\()Tj 0.396 0.396 0.388 rg 0.05 Tc 11.702 0 0 8.3 114.12 296.89 Tm (0\) )Tj EMC ET BT 0.326 0.326 0.318 rg /T1_0 1 Tf 8.9033 0 0 8.3 127.12 296.89 Tm (or )Tj 0.259 0.259 0.251 rg 0.0067 Tc 8.3 0 0 8.3 138.23 296.89 Tm (histamine )Tj ET BT /Suspect <>BDC 0.396 0.396 0.388 rg /T1_5 1 Tf 0 Tc 8.7 0 0 8.7 174.11 296.89 Tm (\()Tj 0.165 0.165 0.157 rg 0.392 0 Td (e)Tj 0.396 0.396 0.388 rg 0.772 0 Td (\) )Tj EMC ET BT 0.259 0.259 0.251 rg /T1_0 1 Tf 0.0109 Tc 8.3 0 0 8.3 190.49 296.89 Tm (inhalation. )Tj -0.008 Tc 4.807 0 Td (Abscissa: )Tj 0.0188 Tc 4.218 0 Td (FEY )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 4.8001 0 0 4.8001 282.08 294.97 Tm (1)Tj 0.396 0.396 0.388 rg 0.615 0.4 Td (; )Tj EMC ET BT 0.326 0.326 0.318 rg /T1_0 1 Tf 0.0142 Tc 8.3 0 0 8.3 59.92 287.76 Tm (ordinate: )Tj ET BT /Suspect <>BDC 0.259 0.259 0.251 rg /T1_0 1 Tf -0.035 Tc 7.0677 0 0 9.6 96.95 287.76 Tm (VE)Tj 0.396 0.396 0.388 rg 0 Tc 9.6 0 0 9.6 105.93 287.76 Tm (, )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg -0.035 Tc 8.0599 0 0 8.3 114.22 287.76 Tm (VT/Tr. )Tj EMC ET BT /T1_0 1 Tf -0.0293 Tc 8.6 0 0 8.6 142.51 287.76 Tm (Left )Tj 0.326 0.326 0.318 rg 0.0023 Tc 8.3 0 0 8.3 162.25 287.76 Tm (panels: )Tj 0.0042 Tc 3.583 0 Td (nonsmokers; )Tj 0.0054 Tc 5.957 0 Td (right )Tj 0.259 0.259 0.251 rg -0.0073 Tc 2.663 0 Td (panels: )Tj 0.0081 Tc -24.536 -1.041 Td (smokers)Tj 0.396 0.396 0.388 rg 0 Tc 3.406 0 Td (. )Tj 0.259 0.259 0.251 rg -0.0279 Tc 0.829 0 Td (All )Tj 0.0154 Tc 1.795 0 Td (parameters )Tj 0.0033 Tc 5.078 0 Td (are )Tj -0.0129 Tc 1.792 0 Td (expressed )Tj 0.326 0.326 0.318 rg 0.0465 Tc 4.396 0 Td (as )Tj 0 Tc 1.446 0 Td (a )Tj 0.259 0.259 0.251 rg 0.0024 Tc 1.052 0 Td (percentage )Tj 0.05 Tc 8.9033 0 0 8.3 264.88 279.12 Tm (of )Tj -0.0016 Tc 8.3 0 0 8.3 276.94 279.12 Tm (the )Tj 0.326 0.326 0.318 rg 0.0136 Tc -26.147 -1.099 Td (control )Tj 0.259 0.259 0.251 rg -0.0073 Tc 3.304 0 Td (value. )Tj 0.05 Tc 10.3053 0 0 10 59.95 243.13 Tm (Pao)Tj /T1_2 1 Tf 0 Tc 6.2 0 0 6.2 76.75 240.73 Tm (2)Tj 0.396 0.396 0.388 rg 0.681 0.387 Td (, )Tj 0.259 0.259 0.251 rg /T1_0 1 Tf 0.0081 Tc 10 0 0 10 86.39 243.13 Tm (however, )Tj 0.026 Tc 4.071 0 Td (could )Tj 0.0286 Tc 2.649 0 Td (have )Tj -0.0072 Tc 2.294 0 Td (fallen )Tj 0.0071 Tc 2.595 0 Td (in )Tj 0.0152 Tc 1.11 0 Td (the )Tj 0.026 Tc 1.528 0 Td (case )Tj 0.05 Tc 11.1292 0 0 10 249.49 243.13 Tm (of )Tj 0.326 0.326 0.318 rg 0.0133 Tc 10 0 0 10 260.98 243.13 Tm (severe )Tj 0.259 0.259 0.251 rg 0.0308 Tc -20.097 -1.104 Td (bronchospasm. )Tj 0.05 Tc 10.2656 0 0 10 126.63 232.09 Tm (The )Tj 0.0166 Tc 10 0 0 10 145.83 232.09 Tm (degree )Tj 0.05 Tc 11.1292 0 0 10 176.05 232.09 Tm (of )Tj 0.024 Tc 10 0 0 10 187.67 232.09 Tm (hypoxia )Tj 0.05 Tc 10.6532 0 0 10 223.57 232.09 Tm (and )Tj 0.165 0.165 0.157 rg 0.0166 Tc 10 0 0 10 242.32 232.09 Tm (its )Tj 0.259 0.259 0.251 rg 0.0104 Tc 1.255 0 Td (role )Tj 0.05 Tc 10.2757 0 0 10 273.5 232.09 Tm (are )Tj 0.007 Tc 10 0 0 10 59.43 221.05 Tm (difficult )Tj 0.0413 Tc 3.607 0 Td (to )Tj 0.0052 Tc (visualize, )Tj 0.05 Tc 10.18 0 0 10 149.29 221.05 Tm (but )Tj 0.0034 Tc 10 0 0 10 167.02 221.05 Tm (they )Tj 0.0423 Tc 2.068 0 Td (probably )Tj 0.038 Tc 4.165 0 Td (did )Tj 0.05 Tc 10.1333 0 0 10 246.23 221.05 Tm (not )Tj -0.001 Tc 10 0 0 10 263.9 221.05 Tm (affect )Tj 0.0152 Tc -20.392 -1.104 Td (the )Tj 0.0292 Tc 1.624 0 Td (comparison. )Tj 0.0192 Tc 5.67 0 Td (Firstly, )Tj 0.0071 Tc 3.404 0 Td (in )Tj 0.0152 Tc 1.206 0 Td (the )Tj 0.0164 Tc 1.636 0 Td (presence )Tj 0.05 Tc 11.1292 0 0 10 235.09 210.01 Tm (of )Tj 0 Tc 10 0 0 10 247.1 210.01 Tm (a )Tj 0.0395 Tc 0.921 0 Td (normal )Tj 0.05 Tc 10.6325 0 0 10 59.47 199.44 Tm (Paco)Tj 0 Tc 6.5001 0 0 6.5001 82.04 197.05 Tm (2)Tj 0.396 0.396 0.388 rg 0.582 0.368 Td (, )Tj 0.259 0.259 0.251 rg 0.0152 Tc 10 0 0 10 91.66 199.44 Tm (the )Tj 0.024 Tc 1.585 0 Td (hypoxic )Tj 0.017 Tc 3.592 0 Td (drive )Tj -0.0259 Tc 2.449 0 Td (is )Tj -0.002 Tc 0.861 0 Td (effective )Tj 0.0225 Tc 3.745 0 Td (only )Tj 0.05 Tc 11.3843 0 0 10 235.08 199.44 Tm (at )Tj 0 Tc 10 0 0 10 246.62 199.44 Tm (a )Tj 0.05 Tc 10.3053 0 0 10 254.35 199.44 Tm (Pao)Tj 0 Tc 6.5001 0 0 6.5001 271.16 197.05 Tm (2 )Tj 0.05 Tc 10.5727 0 0 10 278.3 199.44 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0154 Tc 10 0 0 10 59.41 188.41 Tm (70 )Tj EMC ET BT /T1_0 1 Tf -0.0234 Tc 10 0 0 10 73.9 188.41 Tm (mm.Hg )Tj 0.05 Tc 10.5727 0 0 10 107.9 188.41 Tm (or )Tj 0.165 0.165 0.157 rg -0.0143 Tc 10 0 0 10 121.84 188.41 Tm (less )Tj 0.259 0.259 0.251 rg 0 Tc 1.904 0 Td ([ )Tj 0.165 0.165 0.157 rg -0.035 Tc 9.555 0 0 10 144.63 188.41 Tm (17]. )Tj 0.259 0.259 0.251 rg 0.0122 Tc 10 0 0 10 163.5 188.41 Tm (Secondly, )Tj 0.05 Tc 10.0636 0 0 10 208.72 188.41 Tm (in )Tj 0.03 Tc 10 0 0 10 221.14 188.41 Tm (similar )Tj 0.0172 Tc 3.36 0 Td (studies, )Tj 0.0106 Tc -19.522 -1.104 Td (using )Tj 0.0202 Tc 2.638 0 Td (methylcholine)Tj 0.396 0.396 0.388 rg 0 Tc 5.986 0 Td (, )Tj 0.165 0.165 0.157 rg 0.0381 Tc 0.68 0 Td (it )Tj 0.259 0.259 0.251 rg 0.05 Tc 10.0834 0 0 10 162.23 177.37 Tm (has )Tj -0.0015 Tc 10 0 0 10 181.45 177.37 Tm (been )Tj 0.326 0.326 0.318 rg 0.0256 Tc 2.337 0 Td (shown )Tj 0.259 0.259 0.251 rg 0.05 Tc 10.215 0 0 10 236.62 177.37 Tm (that )Tj 0 Tc 10 0 0 10 257.66 177.37 Tm (a )Tj 0.05 Tc 10.0609 0 0 10 266.77 177.37 Tm (75% )Tj 0.0177 Tc 10 0 0 10 58.95 166.33 Tm (decrease )Tj -0.035 Tc 9.9195 0 0 10 100.72 166.33 Tm (in )Tj 0.326 0.326 0.318 rg -0.0011 Tc 10 0 0 10 114.1 166.33 Tm (specific )Tj 0.02 Tc 3.652 0 Td (airways )Tj 0.259 0.259 0.251 rg 0.0308 Tc 3.792 0 Td (conductance )Tj 0.0323 Tc 5.857 0 Td (does )Tj 0.05 Tc 10.1333 0 0 10 272.63 166.33 Tm (not )Tj 0.0086 Tc 10 0 0 10 58.94 155.29 Tm (affect )Tj 0.0152 Tc 2.648 0 Td (the )Tj 0.0299 Tc 1.576 0 Td (arterial )Tj 0.0107 Tc 3.36 0 Td (oxygen )Tj 0.326 0.326 0.318 rg 0.05 Tc 10.5206 0 0 10 167.85 155.29 Tm (satu)Tj 0.165 0.165 0.157 rg 0.0237 Tc 10 0 0 10 186.23 155.29 Tm (ration )Tj 0.259 0.259 0.251 rg 0.028 Tc 2.823 0 Td (and )Tj 0.05 Tc 10.215 0 0 10 233.26 155.29 Tm (that )Tj 10.2654 0 0 10 253.34 155.29 Tm (an )Tj 0.0371 Tc 10 0 0 10 266.7 155.29 Tm (84% )Tj 0.0177 Tc -20.775 -1.056 Td (decrease )Tj 0.022 Tc 4.273 0 Td (induces )Tj 0.0225 Tc 3.934 0 Td (only )Tj 0 Tc 2.592 0 Td (a )Tj 0.326 0.326 0.318 rg 0.0123 Tc 1.244 0 Td (slight )Tj 0.259 0.259 0.251 rg 0.0339 Tc 2.941 0 Td (hypoxaemia )Tj -0.035 Tc 9.6519 0 0 10 268.57 144.73 Tm ([18]. )Tj 0.015 Tc 10 0 0 10 59.48 133.69 Tm (Finally, )Tj -0.0099 Tc 3.788 0 Td (it )Tj 0.0221 Tc 1.056 0 Td (is )Tj 0.0268 Tc 1.207 0 Td (reasonable )Tj 0.0413 Tc 5.087 0 Td (to )Tj 0.0391 Tc 1.392 0 Td (think )Tj 0.05 Tc 10.215 0 0 10 212.62 133.69 Tm (that )Tj 0.0152 Tc 10 0 0 10 234.7 133.69 Tm (the )Tj 0.165 0.165 0.157 rg 0.016 Tc 1.825 0 Td (hypoxic )Tj 0.259 0.259 0.251 rg 0.017 Tc -19.4 -1.105 Td (drive )Tj -0.0068 Tc 2.504 0 Td (was )Tj 0.0392 Tc 1.919 0 Td (the )Tj 0.326 0.326 0.318 rg 0.0284 Tc 1.62 0 Td (same )Tj 0.165 0.165 0.157 rg 0.0071 Tc 2.502 0 Td (in )Tj 0.259 0.259 0.251 rg 0.0148 Tc 1.207 0 Td (response )Tj 0.0413 Tc 3.983 0 Td (to )Tj 0.0349 Tc 1.251 0 Td (both )Tj 0.0467 Tc 2.246 0 Td (drugs )Tj 0.05 Tc 10.0265 0 0 10 258.62 122.64 Tm (and )Tj -0.035 Tc 9.9195 0 0 10 278.32 122.64 Tm (in )Tj 0.0349 Tc 10 0 0 10 59.53 111.6 Tm (both )Tj 0.0271 Tc 2.151 0 Td (groups, )Tj 0.0093 Tc 3.402 0 Td (since )Tj 0.018 Tc 2.364 0 Td (mechanical )Tj 0.019 Tc 4.984 0 Td (changes )Tj 0.0105 Tc 3.561 0 Td (were )Tj 0.0392 Tc 2.255 0 Td (the )Tj 0.0188 Tc 1.524 0 Td (same. )Tj 0.0127 Tc -19.333 -1.056 Td (We )Tj 0.037 Tc 1.721 0 Td (can )Tj 0.0237 Tc 1.832 0 Td (therefore )Tj 0.0266 Tc 4.179 0 Td (be )Tj 0.0258 Tc 1.294 0 Td (reasonably )Tj 0.0289 Tc 4.887 0 Td (confident )Tj 0.05 Tc 10.215 0 0 10 251.02 101.04 Tm (that )Tj 10.5338 0 0 10 271.1 101.04 Tm (our )Tj 0.0288 Tc 10 0 0 10 313.3 756.24 Tm (study )Tj 0.165 0.165 0.157 rg 0.0063 Tc 2.749 0 Td (really )Tj 0.259 0.259 0.251 rg 0.032 Tc 2.727 0 Td (compares )Tj 0.0392 Tc 4.52 0 Td (the )Tj 0.165 0.165 0.157 rg 0.0108 Tc 1.77 0 Td (local )Tj 0.259 0.259 0.251 rg -0.0002 Tc 2.397 0 Td (effects )Tj 0.05 Tc 11.1292 0 0 10 486.13 756.24 Tm (of )Tj 0.0311 Tc 10 0 0 10 499.19 756.24 Tm (histamine )Tj 0.326 0.326 0.318 rg 0.05 Tc 10.0265 0 0 10 313.34 745.68 Tm (and )Tj 0.259 0.259 0.251 rg 0.0162 Tc 10 0 0 10 335.98 745.68 Tm (methylcholine )Tj 0.05 Tc 10.2564 0 0 10 402.62 745.68 Tm (on )Tj 0.0126 Tc 10 0 0 10 420.46 745.68 Tm (vagal )Tj 0.025 Tc 2.968 0 Td (airway )Tj 0.0224 Tc 3.657 0 Td (receptors )Tj 0.0071 Tc 4.553 0 Td (in )Tj 0.0395 Tc -21.929 -1.103 Td (normal )Tj 0.017 Tc 3.395 0 Td (subjects )Tj 0.05 Tc 10.3398 0 0 10 383.41 734.65 Tm (and )Tj 0.326 0.326 0.318 rg 0.0375 Tc 10 0 0 10 402.62 734.65 Tm (asympto)Tj 0.165 0.165 0.157 rg 0.0349 Tc 3.656 0 Td (matic )Tj 0.259 0.259 0.251 rg 0.0269 Tc 2.676 0 Td (smokers. )Tj /T1_3 1 Tf 0.0236 Tc 9.8 0 0 9.8 313.51 707.76 Tm (Resting )Tj 0.0128 Tc 3.463 0 Td (breathing )Tj 0.0373 Tc 4.253 0 Td (pattern )Tj /T1_0 1 Tf 0.0437 Tc 10 0 0 10 323.02 690.97 Tm (Among )Tj 0.0152 Tc 3.504 0 Td (the )Tj 0.0276 Tc 1.635 0 Td (breathing )Tj 0.05 Tc 10.0262 0 0 10 417.62 690.97 Tm (pattern )Tj 0.0316 Tc 10 0 0 10 452.18 690.97 Tm (parameters )Tj 0.0292 Tc 4.98 0 Td (observed )Tj 0.05 Tc 10.0636 0 0 10 312.88 680.41 Tm (in )Tj 10.194 0 0 10 328.7 680.41 Tm (our )Tj 0.0437 Tc 10 0 0 10 350.87 680.41 Tm (non )Tj 0.0304 Tc 2.339 0 Td (smoking )Tj 0.326 0.326 0.318 rg 0.0197 Tc 4.32 0 Td (subjects, )Tj 0.259 0.259 0.251 rg 0.0392 Tc 4.428 0 Td (the )Tj 0.165 0.165 0.157 rg 0.0202 Tc 2.007 0 Td (frequency )Tj 0.259 0.259 0.251 rg 0.05 Tc 11.1292 0 0 10 531.25 680.41 Tm (of )Tj 0.0406 Tc 10 0 0 10 313.45 669.36 Tm (br)Tj 0.396 0.396 0.388 rg 0.0458 Tc 0.852 0 Td (ea)Tj 0.259 0.259 0.251 rg 0.0271 Tc 0.969 0 Td (thing )Tj -0.0068 Tc 2.497 0 Td (was )Tj 0.0111 Tc 1.913 0 Td (lower )Tj 0.0354 Tc 2.694 0 Td (than )Tj 0.326 0.326 0.318 rg 0.0071 Tc 2.202 0 Td (in )Tj 0.259 0.259 0.251 rg 0.05 Tc 10.1049 0 0 10 436.22 669.36 Tm (other )Tj 0.326 0.326 0.318 rg 0.0451 Tc 10 0 0 10 462.1 669.36 Tm (stud)Tj 0.165 0.165 0.157 rg -0.0184 Tc 1.83 0 Td (ies )Tj 0.259 0.259 0.251 rg 0.0106 Tc 1.448 0 Td (using )Tj 0.0461 Tc 2.543 0 Td (non\255)Tj 0.165 0.165 0.157 rg 0.0067 Tc -20.743 -1.103 Td (invasive )Tj 0.259 0.259 0.251 rg 0.0216 Tc 3.798 0 Td (techniques )Tj -0.0262 Tc 4.922 0 Td ([14]. )Tj 0.0186 Tc 2.31 0 Td (Several )Tj 0.0318 Tc 3.511 0 Td (factors )Tj 0.0124 Tc 3.466 0 Td (need )Tj 0.0413 Tc 2.399 0 Td (to )Tj -0.0214 Tc 1.395 0 Td (be )Tj 0.326 0.326 0.318 rg 0.0227 Tc -21.851 -1.057 Td (considered )Tj 0.165 0.165 0.157 rg 0.0071 Tc 5.282 0 Td (in )Tj 0.259 0.259 0.251 rg 0.0192 Tc 1.488 0 Td (identifying )Tj 0.326 0.326 0.318 rg 0.05 Tc 10.2 0 0 10 432.94 647.76 Tm (the )Tj 0.259 0.259 0.251 rg 0.0353 Tc 10 0 0 10 453.59 647.76 Tm (reason )Tj 0.165 0.165 0.157 rg 0.0314 Tc 3.494 0 Td (for )Tj 0.259 0.259 0.251 rg 0.0218 Tc 2.013 0 Td (such )Tj 0 Tc 2.644 0 Td (a )Tj -0.0017 Tc -22.223 -1.103 Td (difference. )Tj 0.165 0.165 0.157 rg 0.05 Tc 10.2656 0 0 10 359.43 636.73 Tm (The )Tj 0.259 0.259 0.251 rg -0.0043 Tc 10 0 0 10 380.65 636.73 Tm (bellow )Tj 0.165 0.165 0.157 rg 0.0303 Tc 3.121 0 Td (pneum)Tj 0.326 0.326 0.318 rg 0.0457 Tc 2.916 0 Td (otachograph )Tj 0.259 0.259 0.251 rg 0.0249 Tc 5.816 0 Td (technique )Tj 0.05 Tc 10.1238 0 0 10 312.01 625.68 Tm (bas )Tj 0.0145 Tc 10 0 0 10 330.25 625.68 Tm (been )Tj 0.0149 Tc 2.197 0 Td (carefully )Tj 0.0292 Tc 3.992 0 Td (validated )Tj 0.05 Tc 10.0265 0 0 10 434.3 625.68 Tm (and )Tj -0.0068 Tc 10 0 0 10 453.59 625.68 Tm (was )Tj 0.018 Tc 1.863 0 Td (checked )Tj 0.0343 Tc 3.744 0 Td (against )Tj 0.0234 Tc -19.726 -1.103 Td (inductive )Tj 0.0261 Tc 4.57 0 Td (plethysmography )Tj -0.035 Tc 9.6519 0 0 10 438.01 614.65 Tm ([11]. )Tj 0.0323 Tc 10 0 0 10 462.19 614.65 Tm (However, )Tj 0.0071 Tc 4.845 0 Td (in )Tj 0.05 Tc 10.5338 0 0 10 525.02 614.65 Tm (our )Tj 0.0157 Tc 10 0 0 10 312.94 604.09 Tm (technique, )Tj 0.0225 Tc 4.552 0 Td (only )Tj 0.0268 Tc 2.168 0 Td (thin)Tj 0.396 0.396 0.388 rg 0 Tc 1.666 0 Td (, )Tj 0.165 0.165 0.157 rg 0.0261 Tc 0.488 0 Td (light )Tj 0.259 0.259 0.251 rg 0.016 Tc 2.202 0 Td (strings )Tj 0.05 Tc 10.2757 0 0 10 453.98 604.09 Tm (are )Tj 0.0407 Tc 10 0 0 10 469.82 604.09 Tm (attached )Tj 0.05 Tc 10.0301 0 0 10 509.18 604.09 Tm (around )Tj 0.0152 Tc 10 0 0 10 312.94 593.05 Tm (the )Tj 0.008 Tc 1.96 0 Td (chest )Tj 0.05 Tc 10.0265 0 0 10 360.86 593.05 Tm (and )Tj 0.0392 Tc 10 0 0 10 383.98 593.05 Tm [(the )-379(abdomen, )]TJ 0.0063 Tc 6.913 0 Td (while, )Tj 0.0071 Tc 3.257 0 Td (in )Tj 0.0294 Tc 1.488 0 Td (inductive )Tj 0.0237 Tc -18.758 -1.105 Td (plethysmography, )Tj 0.0392 Tc 7.868 0 Td (the )Tj 0.0207 Tc 1.572 0 Td (subject )Tj -0.035 Tc 9.3682 0 0 10 440.08 582 Tm (is )Tj 0.0432 Tc 10 0 0 10 448.79 582 Tm (wrapped )Tj 0.05 Tc 10.0636 0 0 10 488.56 582 Tm (in )Tj 0.0437 Tc 10 0 0 10 500.14 582 Tm (two )Tj 0.165 0.165 0.157 rg 0.0314 Tc 1.914 0 Td (larg)Tj 0.326 0.326 0.318 rg 0 Tc 1.629 0 Td (e )Tj 0.259 0.259 0.251 rg 0.002 Tc -22.307 -1.103 Td (pieces )Tj 0.05 Tc 10.5727 0 0 10 341.18 570.97 Tm (of )Tj 0.0185 Tc 10 0 0 10 353.17 570.97 Tm (elastic )Tj 0.0036 Tc 3.033 0 Td (tissue. )Tj ET BT /Suspect <>BDC 0.165 0.165 0.157 rg /T1_0 1 Tf 0.05 Tc 10.2894 0 0 10 413.18 570.97 Tm (Our )Tj EMC ET BT 0.259 0.259 0.251 rg /T1_0 1 Tf 0.0309 Tc 10 0 0 10 433.9 570.97 Tm (technique )Tj 0.0274 Tc 4.504 0 Td (also )Tj 0.0308 Tc 2.072 0 Td (markedly )Tj -0.0012 Tc -18.727 -1.056 Td (differs )Tj 0.0339 Tc 3.118 0 Td (from )Tj 0.0152 Tc 2.649 0 Td (the )Tj 0.0316 Tc 1.816 0 Td (canopy )Tj 0.326 0.326 0.318 rg 0.0069 Tc 3.596 0 Td (system )Tj 0.259 0.259 0.251 rg -0.0039 Tc 3.35 0 Td ([19, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0254 Tc 10 0 0 10 478.5 560.41 Tm (20]. )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.2656 0 0 10 499.11 560.41 Tm (The )Tj 0.0174 Tc 10 0 0 10 521.74 560.41 Tm (time )Tj 0.396 0.396 0.388 rg 0 Tc -20.94 -1.105 Td (s)Tj 0.259 0.259 0.251 rg 0.0217 Tc 0.4 0 Td (pent )Tj 0.0284 Tc 2.292 0 Td (on )Tj 0.05 Tc 10.1109 0 0 10 354.14 549.36 Tm (data )Tj 0.0236 Tc 10 0 0 10 377.18 549.36 Tm (acquisition )Tj 0.05 Tc 10.0691 0 0 10 427.66 549.36 Tm (might )Tj 0.0274 Tc 10 0 0 10 456.86 549.36 Tm (also )Tj 0.165 0.165 0.157 rg 0.0286 Tc 2.169 0 Td (have )Tj 0.259 0.259 0.251 rg 0.026 Tc 2.403 0 Td (played )Tj 0.326 0.326 0.318 rg 0 Tc 3.204 0 Td (a )Tj 0.259 0.259 0.251 rg 0.0053 Tc -22.215 -1.103 Td (role. )Tj 0.05 Tc 10.4358 0 0 10 334.03 538.33 Tm (For )Tj 0.0235 Tc 10 0 0 10 351.73 538.33 Tm (example)Tj 0.396 0.396 0.388 rg 0 Tc 3.547 0 Td (, )Tj 0.259 0.259 0.251 rg 0.05 Tc 10.615 0 0 10 391.59 538.33 Tm (it )Tj 0.0172 Tc 10 0 0 10 400.31 538.33 Tm (was )Tj 0 Tc 1.859 0 Td (5 )Tj 0.0172 Tc 0.684 0 Td (min )Tj 0.0309 Tc 9.7 0 0 9.7 444.4 538.33 Tm (in )Tj 0.05 Tc 10.5338 0 0 10 454.94 538.33 Tm (our )Tj 0.0307 Tc 10 0 0 10 472.18 538.33 Tm (study, )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0 Tc 9.4 0 0 9.4 501.34 538.33 Tm (I )Tj EMC ET BT /T1_0 1 Tf 10 0 0 10 505.78 538.33 Tm (5 )Tj 0.0172 Tc 0.732 0 Td (min )Tj 0.05 Tc 10.0636 0 0 9.7 531.28 538.33 Tm (in )Tj 0.0392 Tc 10 0 0 10 312.46 527.29 Tm (the )Tj 0.326 0.326 0.318 rg 0.0288 Tc 1.668 0 Td (study )Tj 0.259 0.259 0.251 rg 0.0176 Tc 2.655 0 Td (by )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.05 Tc 8.1028 0 0 7.8001 369 527.29 Tm (CHADHA )Tj EMC ET BT 0.326 0.326 0.318 rg /T1_3 1 Tf 10.1514 0 0 9.8 408.87 527.29 Tm (et )Tj 0.259 0.259 0.251 rg -0.035 Tc 9.6185 0 0 9.8 420.42 527.29 Tm (a/. )Tj /T1_0 1 Tf 9.9277 0 0 10 434.16 527.29 Tm ([18], )Tj -0.0016 Tc 10 0 0 10 455.99 527.29 Tm (while )Tj -0.035 Tc 8.6714 0 0 10 481.39 527.29 Tm (LOVERIDGE )Tj /T1_3 1 Tf 0.05 Tc 10.1514 0 0 9.8 531.75 527.29 Tm (et )Tj 0.0402 Tc 9.5 0 0 9.5 312.42 516.73 Tm (a/)Tj 0.396 0.396 0.388 rg 0 Tc 0.856 0 Td (. )Tj 0.259 0.259 0.251 rg /T1_0 1 Tf 0.0175 Tc 10 0 0 10 324.85 516.73 Tm (exposed )Tj 0.165 0.165 0.157 rg 0.0231 Tc 3.657 0 Td (their )Tj 0.259 0.259 0.251 rg 0.0239 Tc 2.148 0 Td (subjects )Tj 0.0413 Tc 3.66 0 Td (to )Tj 0 Tc 1.096 0 Td (a )Tj -0.0247 Tc 0.726 0 Td (45 )Tj -0.0068 Tc 1.298 0 Td (min )Tj 0.0314 Tc 1.825 0 Td (recording )Tj 0.0288 Tc 4.371 0 Td (period )Tj -0.035 Tc 9.9277 0 0 10 312.24 505.69 Tm ([21]. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0482 Tc 10 0 0 10 333.5 505.69 Tm (On )Tj EMC ET BT /T1_0 1 Tf 0.0392 Tc 10 0 0 10 349.9 505.69 Tm (the )Tj 0.05 Tc 10.1049 0 0 10 366.14 505.69 Tm (other )Tj 0.165 0.165 0.157 rg 10.1097 0 0 10 392.15 505.69 Tm (hand)Tj 0.396 0.396 0.388 rg 0 Tc 10 0 0 10 413.6 505.69 Tm (, )Tj 0.259 0.259 0.251 rg 0.0381 Tc 0.584 0 Td (it )Tj -0.0068 Tc 0.967 0 Td (was )Tj 0.326 0.326 0.318 rg 0.0376 Tc 1.859 0 Td (shown )Tj 0.259 0.259 0.251 rg 0.0176 Tc 3.135 0 Td (by )Tj -0.035 Tc 9.0182 0 0 10 492.87 505.69 Tm (GILBERT )Tj /T1_3 1 Tf 0.05 Tc 10.1514 0 0 9.8 531.75 505.69 Tm (et )Tj /T1_4 1 Tf -0.0277 Tc 9.3 0 0 9.3 311.88 494.65 Tm (a!. )Tj /T1_0 1 Tf 0.0318 Tc 10 0 0 10 326.86 494.65 Tm (that, )Tj 0.0071 Tc 2.346 0 Td (in )Tj 0.0158 Tc 1.206 0 Td (this )Tj 0.165 0.165 0.157 rg 0.016 Tc 1.92 0 Td (kind )Tj 0.259 0.259 0.251 rg 0.05 Tc 11.1292 0 0 10 404.53 494.65 Tm (of )Tj 0.0307 Tc 10 0 0 10 417.46 494.65 Tm (study, )Tj 0.05 Tc 10.1109 0 0 10 447.26 494.65 Tm (data )Tj 0.0395 Tc 10 0 0 10 469.82 494.65 Tm (obtained )Tj 0.0366 Tc 4.177 0 Td (during )Tj 0.0152 Tc -19.913 -1.104 Td (the )Tj 0.0165 Tc 1.524 0 Td (second )Tj 0.0317 Tc 3.18 0 Td (minute )Tj 0.044 Tc 3.208 0 Td (are )Tj 0.0233 Tc 1.593 0 Td (representative )Tj 0.05 Tc 11.6856 0 0 10 469.33 483.61 Tm (of )Tj 0.0392 Tc 10 0 0 10 481.42 483.61 Tm (the )Tj 0.0154 Tc 1.585 0 Td (rest )Tj 0.05 Tc 11.1292 0 0 10 514.93 483.61 Tm (of )Tj 0.0392 Tc 10 0 0 10 526.54 483.61 Tm (the )Tj 0.0194 Tc -21.407 -1.056 Td (recording )Tj -0.035 Tc 9.4074 0 0 10.4 357.37 473.05 Tm ([6\). )Tj 0.0477 Tc 10 0 0 10 374.79 473.05 Tm (The )Tj 0.0194 Tc 2.167 0 Td (type )Tj 0.05 Tc 10.5727 0 0 10 419.42 473.05 Tm (of )Tj 0.017 Tc 10 0 0 10 432.82 473.05 Tm (subjects )Tj 0.0106 Tc 3.84 0 Td (selected )Tj 0.0314 Tc 3.747 0 Td (for )Tj 0.0392 Tc 1.785 0 Td (the )Tj 0.326 0.326 0.318 rg 0.0288 Tc -21.468 -1.105 Td (study )Tj 0.259 0.259 0.251 rg 0.0219 Tc 2.836 0 Td (certainly )Tj 0.015 Tc 4.284 0 Td (plays )Tj 0 Tc 2.772 0 Td (a )Tj 0.0426 Tc 1.064 0 Td (major )Tj 0.0173 Tc 3.073 0 Td (role. )Tj ET BT /Suspect <>BDC 0.165 0.165 0.157 rg /T1_0 1 Tf 0.0474 Tc 10 0 0 10 477.02 462 Tm (Ours )Tj EMC ET BT 0.259 0.259 0.251 rg /T1_0 1 Tf 0.0105 Tc 10 0 0 10 503.99 462 Tm (were )Tj 0.011 Tc 2.487 0 Td (all )Tj 0.0177 Tc -21.684 -1.103 Td (physicians )Tj 0.05 Tc 10.5727 0 0 10 359.42 450.97 Tm (or )Tj 0.0181 Tc 10 0 0 10 372.94 450.97 Tm (medical )Tj 0.0305 Tc 3.684 0 Td (students, )Tj 0.0254 Tc 4.224 0 Td (some )Tj 0.05 Tc 11.1292 0 0 10 477.97 450.97 Tm (of )Tj 0.0231 Tc 10 0 0 10 491.02 450.97 Tm (them )Tj 0.0234 Tc 2.547 0 Td (being )Tj 0.019 Tc -20.46 -1.104 Td (familiar )Tj 0.0175 Tc 3.802 0 Td (with )Tj 0.0392 Tc 2.303 0 Td (the )Tj 0.0269 Tc 1.776 0 Td (techniques )Tj 0.05 Tc 11.1292 0 0 10 440.53 439.93 Tm (of )Tj 0.165 0.165 0.157 rg 0.0271 Tc 10 0 0 10 454.07 439.93 Tm (respira)Tj 0.326 0.326 0.318 rg 0.0401 Tc 2.927 0 Td (tory )Tj 0.259 0.259 0.251 rg 0.0133 Tc 2.212 0 Td (physiol\255)Tj -0.0005 Tc -19.356 -1.056 Td (ogy. )Tj 0.0305 Tc 2.168 0 Td (Although )Tj 0.0194 Tc 4.368 0 Td (they )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.038 Tc 10 0 0 10 398.31 429.37 Tm (did )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.1333 0 0 10 415.67 429.37 Tm (not )Tj 0.0276 Tc 10 0 0 10 433.42 429.37 Tm (know )Tj 0.0392 Tc 2.688 0 Td (the )Tj 0.042 Tc 1.636 0 Td (purpose )Tj 0.05 Tc 11.6856 0 0 10 513.97 429.37 Tm (of )Tj 0.0392 Tc 10 0 0 10 526.54 429.37 Tm (the )Tj 0.326 0.326 0.318 rg 0.05 Tc 10.0585 0 0 10 311.38 418.33 Tm (stu)Tj 0.165 0.165 0.157 rg 0.017 Tc 10 0 0 10 324.39 418.33 Tm (dy )Tj 0.259 0.259 0.251 rg 0.0194 Tc 1.447 0 Td (they )Tj 0.0105 Tc 2.113 0 Td (were )Tj 0.0219 Tc 2.343 0 Td (certainly )Tj -0.0143 Tc 4.082 0 Td (less )Tj 0.0086 Tc 1.822 0 Td (affected )Tj 0.0176 Tc 3.707 0 Td (by )Tj 0.0315 Tc 1.329 0 Td (stress )Tj 0.05 Tc 10.0233 0 0 10 520.3 418.33 Tm (than )Tj 0.0159 Tc 10 0 0 10 311.42 407.28 Tm (completely )Tj 0.0241 Tc 5.049 0 Td (naive )Tj 0.326 0.326 0.318 rg 0 Tc 2.675 0 Td (s)Tj 0.165 0.165 0.157 rg 0.0098 Tc 0.446 0 Td (ubj)Tj 0.326 0.326 0.318 rg -0.0016 Tc 1.333 0 Td (ects. )Tj 0.259 0.259 0.251 rg 0.0375 Tc 2.258 0 Td (This )Tj 0.165 0.165 0.157 rg 0 Tc 2.401 0 Td (i)Tj 0.326 0.326 0.318 rg 0.234 0 Td (s )Tj 0.0483 Tc 0.816 0 Td (su)Tj 0.165 0.165 0.157 rg 0.0447 Tc 0.976 0 Td (pported )Tj 0.259 0.259 0.251 rg 0.0176 Tc 3.839 0 Td (by )Tj 0.0392 Tc 1.437 0 Td (the )Tj 0.165 0.165 0.157 rg 0.0069 Tc -21.417 -1.103 Td (fact )Tj 0.259 0.259 0.251 rg 0.0458 Tc 1.881 0 Td (that )Tj 0.326 0.326 0.318 rg 0.05 Tc 10.4453 0 0 10 349.77 396.25 Tm (stu)Tj 0.165 0.165 0.157 rg -0.0053 Tc 10 0 0 10 362.79 396.25 Tm (dies )Tj 0.0106 Tc 1.929 0 Td (using )Tj 0.259 0.259 0.251 rg -0.0079 Tc 2.542 0 Td (tlie )Tj 0.326 0.326 0.318 rg 0.0284 Tc 1.524 0 Td (same )Tj 0.259 0.259 0.251 rg 0.0249 Tc 2.46 0 Td (technique )Tj 0.0071 Tc 4.362 0 Td (in )Tj 0.0392 Tc 1.11 0 Td (the )Tj 0.326 0.326 0.318 rg 0.0284 Tc 1.572 0 Td (same )Tj 0.259 0.259 0.251 rg 0.0361 Tc -20.586 -1.104 Td (laboratory )Tj 0.0162 Tc 4.8 0 Td (gave )Tj 0.0134 Tc 2.311 0 Td (results )Tj 0.022 Tc 3.011 0 Td (similar )Tj 0.0413 Tc 3.276 0 Td (to )Tj 0.0392 Tc 1.2 0 Td (the )Tj 0.0327 Tc 1.636 0 Td (present )Tj 0.0201 Tc 3.444 0 Td (ones )Tj 0.326 0.326 0.318 rg 0.0071 Tc 2.258 0 Td (in )Tj 0.259 0.259 0.251 rg 0.0191 Tc -21.936 -1.056 Td (initiated )Tj 0.0137 Tc 3.93 0 Td (subjects, )Tj 0.05 Tc 10.0265 0 0 10 392.54 374.65 Tm (and )Tj 10.377 0 0 10 413.18 374.65 Tm (data )Tj 0.326 0.326 0.318 rg -0.035 Tc 9.5089 0 0 10 437.15 374.65 Tm (si)Tj 0.165 0.165 0.157 rg 0.0264 Tc 10 0 0 10 443.98 374.65 Tm (milar )Tj 0.259 0.259 0.251 rg 0.0413 Tc 2.736 0 Td (to )Tj 0.0253 Tc 1.392 0 Td (those )Tj 0.05 Tc 11.6856 0 0 10 512.05 374.65 Tm (of )Tj 10.2 0 0 10 526.06 374.65 Tm (the )Tj 0.0227 Tc 10 0 0 10 311.92 363.61 Tm (literature )Tj 0.165 0.165 0.157 rg 0.0071 Tc 4.176 0 Td (in )Tj 0.259 0.259 0.251 rg 0.0159 Tc 1.15 0 Td (completely )Tj 0.0121 Tc 4.953 0 Td (naive )Tj 0.326 0.326 0.318 rg 0.0239 Tc 2.579 0 Td (subjects )Tj 0.259 0.259 0.251 rg -0.0199 Tc 3.686 0 Td ([11, )Tj -0.035 Tc 9.8692 0 0 10 496.26 363.61 Tm (22]. )Tj 0.0477 Tc 10 0 0 10 321.03 352.56 Tm (The )Tj 0.05 Tc 10.0262 0 0 10 344.66 352.56 Tm (pattern )Tj 10.5727 0 0 10 382.46 352.56 Tm (of )Tj 0.0336 Tc 10 0 0 10 398.41 352.56 Tm (breathing )Tj 0.05 Tc 11.1292 0 0 10 445.33 352.56 Tm (of )Tj 0.0392 Tc 10 0 0 10 461.26 352.56 Tm (the )Tj 0.025 Tc 2.004 0 Td (smokers )Tj 0.0172 Tc 4.189 0 Td (was )Tj 0.165 0.165 0.157 rg 0.0152 Tc -21.176 -1.103 Td (different )Tj 0.259 0.259 0.251 rg 0.0179 Tc 4.03 0 Td (from )Tj 0.05 Tc 10.215 0 0 10 376.78 341.53 Tm (that )Tj 0.0007 Tc 10 0 0 10 398.32 341.53 Tm (given )Tj -0.0304 Tc 2.745 0 Td (by )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.7829 0 0 10 440.09 341.53 Tm (TOBIN )Tj EMC ET BT /T1_3 1 Tf 0.05 Tc 10.7859 0 0 9.8 470.3 341.53 Tm (et )Tj 0.0052 Tc 9.8 0 0 9.8 482.82 341.53 Tm (a/. )Tj /T1_0 1 Tf -0.0262 Tc 10 0 0 10 497.52 341.53 Tm ([23]. )Tj 0.0457 Tc 2.321 0 Td (In )Tj 0 Tc 1.341 0 Td (a )Tj 0.0444 Tc -22.27 -1.104 Td (group )Tj 0.05 Tc 11.1292 0 0 10 340.21 330.49 Tm (of )Tj -0.0211 Tc 10 0 0 10 352.74 330.49 Tm (22 )Tj 0.0371 Tc 1.34 0 Td (asymptomatic )Tj 0.0269 Tc 6.38 0 Td (smokers, )Tj 0.0431 Tc 4.18 0 Td (as )Tj 0.0436 Tc 1.2 0 Td (compared )Tj 0.05 Tc 10.4772 0 0 10 530.37 330.49 Tm (to )Tj 0.0395 Tc 10 0 0 10 311.51 319.93 Tm (normal )Tj 0.0343 Tc 3.648 0 Td (nonsmokers )Tj 0.05 Tc 10.5727 0 0 10 405.5 319.93 Tm (of )Tj 0.0152 Tc 10 0 0 10 420.46 319.93 Tm (the )Tj 0.0284 Tc 1.86 0 Td (same )Tj 0.0184 Tc 2.74 0 Td (age, )Tj 0.0194 Tc 2.312 0 Td (they )Tj 0.165 0.165 0.157 rg 0.048 Tc 2.391 0 Td (found )Tj 0.326 0.326 0.318 rg -0.0184 Tc -20.211 -1.104 Td (sig)Tj 0.165 0.165 0.157 rg 0.0242 Tc 1.117 0 Td (nificant )Tj 0.326 0.326 0.318 rg 0 Tc 3.545 0 Td (i)Tj 0.165 0.165 0.157 rg 0.0109 Tc 0.295 0 Td (ncreases )Tj 0.259 0.259 0.251 rg 0.0071 Tc 3.785 0 Td (in )Tj -0.035 Tc 9.309 0 0 10 410.78 308.89 Tm (f, )Tj ET BT /Suspect <>BDC 0.165 0.165 0.157 rg /T1_0 1 Tf 9.6716 0 0 10 419.98 308.89 Tm (VT)Tj 0.326 0.326 0.318 rg 0 Tc 10 0 0 10 432.32 308.89 Tm (, )Tj EMC /Suspect <>BDC 0.259 0.259 0.251 rg -0.035 Tc 8.9276 0 0 12 438.22 308.89 Tm (VE )Tj EMC ET BT 0.326 0.326 0.318 rg /T1_0 1 Tf 0.05 Tc 10.3398 0 0 10 453.49 308.89 Tm (and )Tj ET BT /Suspect <>BDC 0.259 0.259 0.251 rg /T1_0 1 Tf -0.0119 Tc 10 0 0 10 472.78 308.89 Tm (VT/TI, )Tj EMC ET BT /T1_0 1 Tf -0.0016 Tc 10 0 0 10 503.99 308.89 Tm (while )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.3221 0 0 10 529.35 308.89 Tm (Tr )Tj EMC ET BT /T1_0 1 Tf 10.0265 0 0 10 310.94 297.84 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0145 Tc 10 0 0 10 329.19 297.84 Tm (TI)Tj 0.396 0.396 0.388 rg 0 Tc 0.969 0 Td (/)Tj 0.165 0.165 0.157 rg 0.327 0 Td (T)Tj 0.326 0.326 0.318 rg 0.0242 Tc 5.2 0 0 5.2 348.78 295.93 Tm (101 )Tj EMC ET BT 0.259 0.259 0.251 rg /T1_0 1 Tf 0.0105 Tc 10 0 0 10 359.03 297.84 Tm (were )Tj 0.326 0.326 0.318 rg 0.0481 Tc 2.195 0 Td (sma)Tj 0.165 0.165 0.157 rg -0.0192 Tc 1.782 0 Td (ller. )Tj 0.259 0.259 0.251 rg 0.0457 Tc 1.825 0 Td (In )Tj 0.0392 Tc 1.205 0 Td (the )Tj 0.0327 Tc 1.588 0 Td (present )Tj 0.0408 Tc 3.296 0 Td (study )Tj 0.326 0.326 0.318 rg 0.033 Tc 2.544 0 Td (smokers )Tj 0.259 0.259 0.251 rg 0.038 Tc -19.243 -1.103 Td (did )Tj 0.05 Tc 10.1333 0 0 10 330.23 286.81 Tm (not )Tj 0.0092 Tc 10 0 0 10 348.87 286.81 Tm (differ )Tj 0.0179 Tc 2.734 0 Td (from )Tj 0.165 0.165 0.157 rg 0 Tc 2.554 0 Td (n)Tj 0.326 0.326 0.318 rg 0.0419 Tc 0.567 0 Td (onsmoke)Tj 0.165 0.165 0.157 rg 0 Tc 3.897 0 Td (r)Tj 0.326 0.326 0.318 rg -0.035 Tc 9.9525 0 0 10 449.62 286.81 Tm (s. )Tj 0.259 0.259 0.251 rg 0.0196 Tc 10 0 0 10 461.74 286.81 Tm (Again, )Tj 0.0158 Tc 3.36 0 Td (this )Tj 0.038 Tc 1.96 0 Td (could )Tj 0.0171 Tc -20.343 -1.105 Td (result )Tj 0.0179 Tc 2.63 0 Td (from )Tj 0.0207 Tc 2.349 0 Td (subject )Tj 0.0099 Tc 3.221 0 Td (difference )Tj 0.0225 Tc 4.415 0 Td (only)Tj 0.396 0.396 0.388 rg 0 Tc 1.866 0 Td (, )Tj 0.259 0.259 0.251 rg 0.0093 Tc 0.578 0 Td (since )Tj 0.05 Tc 10.194 0 0 10 486.14 275.76 Tm (our )Tj 0.326 0.326 0.318 rg 0.033 Tc 10 0 0 10 503.38 275.76 Tm (smokers )Tj 0.259 0.259 0.251 rg 0.0105 Tc -19.235 -1.055 Td (were )Tj 0.011 Tc 2.391 0 Td (all )Tj 0.0197 Tc 1.452 0 Td (physicians. )Tj 0.165 0.165 0.157 rg /T1_2 1 Tf 0.05 Tc 12.2371 0 0 10 400.94 265.21 Tm (It )Tj /T1_0 1 Tf 0 Tc 10 0 0 10 412.72 265.21 Tm (i)Tj 0.326 0.326 0.318 rg 0.234 0 Td (s )Tj 0.259 0.259 0.251 rg 0.0216 Tc 0.87 0 Td (interesting )Tj 0.165 0.165 0.157 rg 0.0413 Tc 4.902 0 Td (to )Tj 0.259 0.259 0.251 rg 0.0358 Tc 1.345 0 Td (note )Tj 0.05 Tc 10.215 0 0 10 509.26 265.21 Tm (that )Tj 0.326 0.326 0.318 rg 0.0071 Tc 10 0 0 10 530.8 265.21 Tm (in )Tj 0.259 0.259 0.251 rg 0.0269 Tc -21.99 -1.105 Td (smokers, )Tj 0.165 0.165 0.157 rg 0 Tc 4.275 0 Td (f )Tj 0.259 0.259 0.251 rg 0.0172 Tc 0.778 0 Td (was )Tj 0.326 0.326 0.318 rg 0.0352 Tc 2.051 0 Td (somewhat )Tj 0.259 0.259 0.251 rg 0.0111 Tc 4.806 0 Td (lower )Tj 0.05 Tc 10.3398 0 0 10 457.81 254.16 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.6716 0 0 10 479.02 254.16 Tm (VT )Tj EMC ET BT /T1_0 1 Tf 0.042 Tc 10 0 0 10 495.7 254.16 Tm (somewhat )Tj 0.0268 Tc -18.474 -1.103 Td (larger )Tj 0.0354 Tc 2.79 0 Td (than )Tj 0.0071 Tc 2.154 0 Td (in )Tj 0.0298 Tc 1.111 0 Td (nonsmokers, )Tj 0.0369 Tc 5.703 0 Td (although )Tj 0.0198 Tc 4.089 0 Td (height )Tj 0.05 Tc 10.0265 0 0 10 498.62 243.13 Tm (and )Tj 0.0405 Tc 10 0 0 10 517.45 243.13 Tm (body )Tj 0.0139 Tc -20.642 -1.104 Td (weight )Tj 0.0071 Tc 3.065 0 Td (in )Tj 0.025 Tc 1.098 0 Td (smokers )Tj -0.0055 Tc 3.805 0 Td (were )Tj 0.326 0.326 0.318 rg 0.0143 Tc 2.195 0 Td (slightly )Tj 0.259 0.259 0.251 rg 0.05 Tc 10.2005 0 0 10 446.28 232.09 Tm (\(but )Tj 10.4827 0 0 10 467.03 232.09 Tm (not )Tj 0.0132 Tc 10 0 0 10 483.7 232.09 Tm (significantly\) )Tj 0.0068 Tc -17.274 -1.104 Td (lower. )Tj 0.05 Tc 10.0747 0 0 10 341.73 221.05 Tm (We )Tj 0.0286 Tc 10 0 0 10 360.95 221.05 Tm (have )Tj 0.0113 Tc 2.496 0 Td (no )Tj 0.0352 Tc 1.526 0 Td (explanation )Tj 0.0314 Tc 5.52 0 Td (for )Tj 0.0158 Tc 1.785 0 Td (this )Tj 0.0295 Tc 2.016 0 Td (trend. )Tj 0.165 0.165 0.157 rg 0.05 Tc 10.0747 0 0 10 524.13 221.05 Tm (We )Tj 0.259 0.259 0.251 rg 0.0418 Tc 10 0 0 10 311.02 210.49 Tm (must )Tj 0.0321 Tc 2.304 0 Td (mention, )Tj 0.015 Tc 4.033 0 Td (however, )Tj 0.05 Tc 10.215 0 0 10 415.66 210.49 Tm (that )Tj -0.0086 Tc 10 0 0 10 434.87 210.49 Tm (we )Tj 0.038 Tc 1.384 0 Td (did )Tj 0.05 Tc 10.4827 0 0 10 465.11 210.49 Tm (not )Tj 0.165 0.165 0.157 rg 0.027 Tc 10 0 0 10 482.42 210.49 Tm (pay )Tj 0.259 0.259 0.251 rg 0.0446 Tc 1.764 0 Td (attention )Tj 0.326 0.326 0.318 rg 0.0413 Tc -18.904 -1.105 Td (to )Tj 0.259 0.259 0.251 rg 0.0152 Tc 1.2 0 Td (the )Tj 0.0135 Tc 1.577 0 Td (delay )Tj 0.0149 Tc 2.554 0 Td (between )Tj 0.0152 Tc 3.789 0 Td (the )Tj 0.0231 Tc 1.578 0 Td (last )Tj 0.326 0.326 0.318 rg 0.029 Tc 1.774 0 Td (cigarette )Tj 0.259 0.259 0.251 rg 0.05 Tc 10.6532 0 0 10 475.09 199.44 Tm (and )Tj 0.0392 Tc 10 0 0 10 494.38 199.44 Tm (the )Tj 0.0206 Tc 1.632 0 Td (testing )Tj 0.05 Tc 11.1292 0 0 10 310.93 188.41 Tm (of )Tj 0.326 0.326 0.318 rg 0 Tc 10 0 0 10 323.02 188.41 Tm (t)Tj 0.165 0.165 0.157 rg 0.337 0 Td (h)Tj 0.326 0.326 0.318 rg 0.518 0 Td (e )Tj 0.259 0.259 0.251 rg 0.0163 Tc 0.765 0 Td (subject, )Tj 0.05 Tc 10.0163 0 0 10 375.26 188.41 Tm (or )Tj 10.4772 0 0 10 387.81 188.41 Tm (to )Tj 0.0152 Tc 10 0 0 10 400.3 188.41 Tm (the )Tj 0.0388 Tc 1.633 0 Td (route )Tj 0.05 Tc 11.1292 0 0 10 442.45 188.41 Tm (of )Tj 0.0396 Tc 10 0 0 10 454.57 188.41 Tm (breathing )Tj 0.165 0.165 0.157 rg -0.0248 Tc 4.391 0 Td ([24)Tj 0.396 0.396 0.388 rg 0 Tc 1.352 0 Td (, )Tj 0.259 0.259 0.251 rg -0.035 Tc 9.8692 0 0 10 517.86 188.41 Tm (25]. )Tj /T1_3 1 Tf 0.0241 Tc 9.8 0 0 9.8 311.19 161.05 Tm (Adaptation )Tj 0.0128 Tc 5.066 0 Td (to )Tj 0.0149 Tc 1.132 0 Td (bronchospasm )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.2894 0 0 10 320.54 144.73 Tm (Our )Tj EMC ET BT /T1_0 1 Tf 10.377 0 0 10 343.1 144.73 Tm (data )Tj 0.165 0.165 0.157 rg 0.0309 Tc 10 0 0 10 368.08 144.73 Tm (indicate )Tj 0.259 0.259 0.251 rg 0.0438 Tc 3.942 0 Td (that, )Tj 0.05 Tc 10.0636 0 0 10 432.88 144.73 Tm (in )Tj 0.0395 Tc 10 0 0 10 447.35 144.73 Tm (normal )Tj 0.025 Tc 3.696 0 Td (nonsmokers, )Tj 0.0301 Tc -17.326 -1.104 Td (bronchospasm )Tj 0.014 Tc 6.519 0 Td (induces )Tj 0.05 Tc 10.2654 0 0 10 411.26 133.69 Tm (an )Tj 0.015 Tc 10 0 0 10 425.68 133.69 Tm (increase )Tj 0.0071 Tc 3.744 0 Td (in )Tj -0.0243 Tc 1.158 0 Td (VT/TI )Tj 0.0146 Tc 2.833 0 Td (which )Tj -0.0259 Tc 2.873 0 Td (is )Tj 0.0448 Tc -22.118 -1.105 Td (proportional )Tj 0.165 0.165 0.157 rg 0.0413 Tc 5.804 0 Td (to )Tj 0.259 0.259 0.251 rg 0.0392 Tc 1.2 0 Td (the )Tj 0.0177 Tc 1.625 0 Td (decrease )Tj 0.05 Tc 10.0636 0 0 10 435.76 122.64 Tm (in )Tj 0.0366 Tc 10 0 0 10 447.25 122.64 Tm (expiratory )Tj -0.0213 Tc 4.8 0 Td (flow. )Tj 0.165 0.165 0.157 rg 0.05 Tc 10.1187 0 0 10 519.27 122.64 Tm (Thi)Tj 0.326 0.326 0.318 rg 0 Tc 10 0 0 10 534.58 122.64 Tm (s )Tj 0.259 0.259 0.251 rg 0.0036 Tc -22.413 -1.104 Td (finding )Tj 0.165 0.165 0.157 rg -0.0259 Tc 3.363 0 Td (is )Tj 0.259 0.259 0.251 rg 0.0071 Tc 1.008 0 Td (in )Tj 0.0356 Tc 1.198 0 Td (accordance )Tj 0.0175 Tc 5.193 0 Td (with )Tj 0.0152 Tc 2.303 0 Td 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2.409 0 Td (not )Tj 0.0004 Tc 1.874 0 Td (differ )Tj 0.0204 Tc 2.728 0 Td (from )Tj 0.0029 Tc 2.597 0 Td (the )Tj 0.0114 Tc 1.789 0 Td (response )Tj 0.0253 Tc 4.093 0 Td (to )Tj 0.0146 Tc -21.412 -1.035 Td (methylcho)Tj 0.118 0.118 0.106 rg 0 Tc 4.37 0 Td (l)Tj 0.271 0.271 0.259 rg -0.0137 Tc 0.283 0 Td (ine )Tj -0.035 Tc 9.7837 0 0 10.2 113.52 570 Tm ([5]. )Tj 0.05 Tc 10.4937 0 0 10.2 129.99 570 Tm (Th)Tj 0.118 0.118 0.106 rg 0 Tc 10.2 0 0 10.2 142.48 570 Tm (i)Tj 0.271 0.271 0.259 rg 0.276 0 Td (s )Tj 0.0295 Tc 0.706 0 Td (study )Tj 0.188 0.192 0.18 rg 0.0105 Tc 2.639 0 Td (only )Tj 0.271 0.271 0.259 rg 0.0048 Tc 2.208 0 Td (shows )Tj 0.05 Tc 10.215 0 0 10.2 231.34 570 Tm (that )Tj 0.0217 Tc 10.2 0 0 10.2 251.98 570 Tm (this )Tj -0.035 Tc 10.1489 0 0 10.2 271.12 570 Tm (is )Tj 0.0164 Tc 10.2 0 0 10.2 50.3 558.97 Tm (also )Tj 0.0321 Tc 2.078 0 Td (true )Tj 0.188 0.192 0.18 rg 0.0192 Tc 2.062 0 Td (for )Tj 0.271 0.271 0.259 rg 0.0264 Tc 1.601 0 Td (asymptomatic )Tj 0.0111 Tc 6.315 0 Td (young )Tj 0.0097 Tc 2.952 0 Td (smokers. )Tj 0.0234 Tc 4.007 0 Td (Interes\255)Tj -0.0046 Tc -18.96 -1.083 Td (tingly)Tj 0.384 0.384 0.372 rg 0 Tc 2.339 0 Td (, )Tj 0.271 0.271 0.259 rg 0.0029 Tc 0.625 0 Td (the )Tj 0.0084 Tc 1.601 0 Td (responses )Tj 0.0253 Tc 4.328 0 Td (to )Tj 0.021 Tc 1.177 0 Td (histamine )Tj 0.05 Tc 10.6532 0 0 10.2 198.13 547.92 Tm (and )Tj 0.0089 Tc 10.2 0 0 10.2 217.9 547.92 Tm (methylcholin)Tj 0.384 0.384 0.372 rg 0 Tc 5.403 0 Td (e )Tj 0.271 0.271 0.259 rg -0.008 Tc -21.835 -1.081 Td (follow )Tj 0.0091 Tc 2.965 0 Td (exactly )Tj 0.0265 Tc 3.303 0 Td (the )Tj 0.0146 Tc 1.635 0 Td (same )Tj 0.0269 Tc 2.51 0 Td (patterns )Tj 0.0261 Tc 3.753 0 Td (as )Tj 0.0029 Tc 1.278 0 Td (the )Tj 0.0084 Tc 1.648 0 Td (responses )Tj -0.0217 Tc 4.375 0 Td (to )Tj 0.0105 Tc -21.459 -1.035 Td (methylcholine )Tj 0.0223 Tc 6.216 0 Td (proposed )Tj -0.0022 Tc 4.281 0 Td (by )Tj /T1_1 1 Tf 0.05 Tc 8.1028 0 0 7.5001 171.72 526.33 Tm (CHADHA )Tj /T1_2 1 Tf 10.1514 0 0 9.9 211.59 526.33 Tm (et )Tj -0.0242 Tc 9.9 0 0 9.9 223.62 526.33 Tm (al. )Tj /T1_0 1 Tf -0.035 Tc 9.9277 0 0 10.2 237.84 526.33 Tm ([18]. )Tj 0.188 0.192 0.18 rg 0.05 Tc 10.4139 0 0 10.2 259.61 526.33 Tm (It )Tj 0.271 0.271 0.259 rg -0.035 Tc 10.1489 0 0 10.2 271.12 526.33 Tm (is )Tj 0.0144 Tc 10.2 0 0 10.2 50.38 515.29 Tm (therefore )Tj 0.0058 Tc 4.224 0 Td (safe )Tj -0.0217 Tc 2.176 0 Td (to )Tj 0.0188 Tc 1.263 0 Td (conclude )Tj 0.0351 Tc 4.29 0 Td (that )Tj 0.0391 Tc 2.159 0 Td (in )Tj 0.0363 Tc 1.276 0 Td (man)Tj 0.384 0.384 0.372 rg 0 Tc 1.869 0 Td (, )Tj 0.271 0.271 0.259 rg 0.0029 Tc 0.767 0 Td (the )Tj 0.0304 Tc 1.788 0 Td (major )Tj 0.188 0.192 0.18 rg 0.0047 Tc -19.811 -1.082 Td (response )Tj 0.271 0.271 0.259 rg 0.0253 Tc 3.999 0 Td (to )Tj 0.0174 Tc 1.216 0 Td (acute )Tj 0.0255 Tc 2.541 0 Td (drug-)Tj 0.118 0.118 0.106 rg 0 Tc 2.308 0 Td (i)Tj 0.271 0.271 0.259 rg 0.0164 Tc 0.289 0 Td (nduced )Tj 0.0236 Tc 3.39 0 Td (bronchospasm )Tj 0.188 0.192 0.18 rg -0.035 Tc 9.3682 0 0 10.2 256.72 504.25 Tm (is )Tj 0.271 0.271 0.259 rg 0.0092 Tc 10.2 0 0 10.2 266.78 504.25 Tm (an )Tj -0.0137 Tc -21.222 -1.082 Td (inc)Tj 0.118 0.118 0.106 rg 0 Tc 1.23 0 Td (r)Tj 0.271 0.271 0.259 rg 0.0034 Tc 0.32 0 Td (eased )Tj 0.188 0.192 0.18 rg 0.019 Tc 2.975 0 Td (respiratory )Tj 0.271 0.271 0.259 rg 0.0184 Tc 5.168 0 Td (drive)Tj 0.384 0.384 0.372 rg 0 Tc 2.112 0 Td (, )Tj 0.271 0.271 0.259 rg 0.05 Tc 10.4827 0 0 10.2 180.47 493.21 Tm (not )Tj 0 Tc 10.2 0 0 10.2 201.02 493.21 Tm (a )Tj 0.0217 Tc 1.129 0 Td (change )Tj 0.0391 Tc 3.578 0 Td (in )Tj 0.0029 Tc 1.512 0 Td (the )Tj 0.0335 Tc -21.031 -1.083 Td (pattern )Tj 0.05 Tc 11.1292 0 0 10.2 84.37 482.16 Tm (of )Tj 0.0142 Tc 10.2 0 0 10.2 96.49 482.16 Tm (breathing. )Tj 0.188 0.192 0.18 rg 0.0252 Tc -3.633 -1.082 Td (This )Tj 0.271 0.271 0.259 rg 0.0158 Tc 2.211 0 Td (observation )Tj 0.0299 Tc 5.223 0 Td (further )Tj 0.0038 Tc 3.197 0 Td (suggests )Tj 0.05 Tc 10.215 0 0 10.2 206.38 471.12 Tm (that )Tj -0.0079 Tc 10.2 0 0 10.2 226.48 471.12 Tm (in )Tj 0.0236 Tc 1.185 0 Td (broncho\255)Tj 0.0171 Tc -18.509 -1.081 Td (spasm)Tj 0.384 0.384 0.372 rg 0 Tc 2.633 0 Td (, )Tj ET BT /Suspect <>BDC 0.271 0.271 0.259 rg /C0_0 1 Tf 5.5201 0 0 7.68 84 460.09 Tm <006D007E0075007400620070>Tj 0.118 0.118 0.106 rg 2.4 0 0 7.68 117.6 460.09 Tm <0069>Tj 0.271 0.271 0.259 rg 4.3201 0 0 7.68 120 460.09 Tm <0065006300650020>Tj EMC ET BT /T1_0 1 Tf 0.037 Tc 10.2 0 0 10.2 138.62 460.09 Tm (and )Tj 0.188 0.192 0.18 rg 0.0022 Tc 2.079 0 Td (noseclip )Tj 0.271 0.271 0.259 rg 0.0087 Tc 3.899 0 Td (interfere )Tj 0.0212 Tc 3.96 0 Td (with )Tj 0.0029 Tc 2.399 0 Td (the )Tj 0.0157 Tc -21.035 -1.035 Td (measurements )Tj 0.05 Tc 11.1292 0 0 10.2 112.69 449.53 Tm (of )Tj 0.0265 Tc 10.2 0 0 10.2 124.3 449.53 Tm (the )Tj 0.0024 Tc 1.545 0 Td (drive, )Tj 0.0487 Tc 2.693 0 Td (but )Tj 0.188 0.192 0.18 rg 0.05 Tc 10.4827 0 0 10.2 184.31 449.53 Tm (not )Tj 0.271 0.271 0.259 rg 0.0056 Tc 10.2 0 0 10.2 201.59 449.53 Tm (with )Tj 0.0029 Tc 2.117 0 Td (the )Tj 0.188 0.192 0.18 rg 0.0155 Tc 1.506 0 Td (measure\255)Tj 0.271 0.271 0.259 rg 0.0164 Tc -18.494 -1.082 Td (ments )Tj 0.05 Tc 11.1292 0 0 10.2 80.53 438.49 Tm (of )Tj 0.0029 Tc 10.2 0 0 10.2 95.5 438.49 Tm (the )Tj 0.188 0.192 0.18 rg 0.0335 Tc 1.792 0 Td (pattern )Tj 0.271 0.271 0.259 rg 0.05 Tc 11.1292 0 0 10.2 149.65 438.49 Tm (of )Tj 0.0194 Tc 10.2 0 0 10.2 164.65 438.49 Tm (breathing, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0008 Tc 10.2 0 0 10.2 212.9776 438.49 Tm (since )Tj EMC ET BT /T1_0 1 Tf 0.0265 Tc 10.2 0 0 10.2 239.977 438.49 Tm (the )Tj 0.0262 Tc 1.78 0 Td (only )Tj -0.0096 Tc -20.424 -1.083 Td (difference )Tj -0.004 Tc 4.575 0 Td (between )Tj 0.0265 Tc 3.856 0 Td (the )Tj 0.0046 Tc 1.836 0 Td (results )Tj 0.0291 Tc 3.144 0 Td (obtained )Tj 0.0116 Tc 4.198 0 Td (using )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0383 Tc 10.2 0 0 10.2 257.266 427.4434 Tm (both )Tj EMC /Suspect <>BDC -0.029 Tc -20.332 -1.081 Td (te<:hniques )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.1489 0 0 10.2 102.16 416.41 Tm (is )Tj 0.0265 Tc 10.2 0 0 10.2 116.14 416.41 Tm (the )Tj 0.0217 Tc 1.969 0 Td (change )Tj -0.0079 Tc 3.673 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.2996 0 0 10.2 189.1 416.41 Tm (VE )Tj EMC ET BT 0.188 0.192 0.18 rg /T1_0 1 Tf 0.0391 Tc 10.2 0 0 10.2 208.24 416.41 Tm (in )Tj 0.271 0.271 0.259 rg 0.0114 Tc 1.56 0 Td (response )Tj 0.188 0.192 0.18 rg 0.05 Tc 10.4772 0 0 10.2 268.29 416.41 Tm (to )Tj 0.271 0.271 0.259 rg 0.02 Tc 10.2 0 0 10.2 49.93 405.37 Tm (bronchoconstriction. )Tj 0.0034 Tc 9.03 0 Td (While )Tj -0.0079 Tc 2.867 0 Td (in )Tj 0.188 0.192 0.18 rg 0.0276 Tc 1.183 0 Td (normal )Tj 0.271 0.271 0.259 rg 0.0096 Tc 3.388 0 Td (resting )Tj 0.0111 Tc 3.144 0 Td (condi\255)Tj 0.009 Tc -19.616 -1.035 Td (tions )Tj 0.0213 Tc 2.353 0 Td (mouthpiece )Tj 0.037 Tc 5.216 0 Td (and )Tj 0.0022 Tc 1.938 0 Td (noseclip )Tj 0.0221 Tc 3.752 0 Td (stimulate )Tj 0.0029 Tc 4.247 0 Td (the )Tj 0.0088 Tc 1.6 0 Td (ventila\255)Tj 0.0084 Tc -19.106 -1.083 Td (tion, )Tj -0.0078 Tc 2.259 0 Td (they )Tj 0.0248 Tc 2.075 0 Td (probably )Tj 0.188 0.192 0.18 rg 0.0301 Tc 4.093 0 Td (blunt )Tj 0.271 0.271 0.259 rg 0.0029 Tc 2.538 0 Td (the )Tj 0.019 Tc 1.601 0 Td (respiratory )Tj 0.0047 Tc 4.941 0 Td (response )Tj 0.0253 Tc 3.905 0 Td (to )Tj 0.0174 Tc -21.467 -1.082 Td (acute )Tj 0.118 0.118 0.106 rg 0.0049 Tc 2.543 0 Td (ind)Tj 0.271 0.271 0.259 rg -0.0167 Tc 1.373 0 Td (uced )Tj 0.0204 Tc 2.26 0 Td (bronchospasm. )Tj /T1_2 1 Tf 0.017 Tc 9.9 0 0 9.9 49.54 345.37 Tm (Mechanisms )Tj 0.004 Tc 5.554 0 Td (involved )Tj -0.0328 Tc 3.685 0 Td (in )Tj -0.0009 Tc 1.164 0 Td (the )Tj 0.0111 Tc 1.558 0 Td (respiratory )Tj -0.0018 Tc 4.994 0 Td (response )Tj -0.035 Tc 9.7843 0 0 9.9 256.2 345.37 Tm (to )Tj 0.005 Tc 9.9 0 0 9.9 49.37 334.33 Tm (bronchospasm )Tj /T1_0 1 Tf 0.0317 Tc 10.2 0 0 10.2 58.95 318 Tm (The )Tj 0.0083 Tc 2.07 0 Td (absence )Tj 0.05 Tc 11.1292 0 0 10.2 117.49 318 Tm (of )Tj 0.0134 Tc 10.2 0 0 10.2 130.94 318 Tm (any )Tj -0.0043 Tc 1.929 0 Td (difference )Tj -0.004 Tc 4.528 0 Td (between )Tj 0.188 0.192 0.18 rg 0.0151 Tc 3.81 0 Td (histamine )Tj 0.271 0.271 0.259 rg 0.037 Tc -18.315 -1.081 Td (and )Tj 0.0066 Tc 2.031 0 Td (methylcholine )Tj 0.118 0.118 0.106 rg 0 Tc 6.253 0 Td (i)Tj 0.271 0.271 0.259 rg 0.289 0 Td (n )Tj 0.0182 Tc 0.988 0 Td (normal )Tj 0.005 Tc 3.375 0 Td (subjects, )Tj 0.0427 Tc 3.956 0 Td (for )Tj 0 Tc 1.695 0 Td (a )Tj 0.0126 Tc 0.89 0 Td (similar )Tj 0.0323 Tc -19.518 -1.082 Td (magnitude )Tj 0.05 Tc 11.1292 0 0 10.2 96.85 295.93 Tm (of )Tj 0.0282 Tc 10.2 0 0 10.2 108.38 295.93 Tm (obstruction, )Tj 0.013 Tc 5.325 0 Td (mechanical )Tj 0.0259 Tc 4.933 0 Td (conditions )Tj 0.037 Tc 4.659 0 Td (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.5657 0 0 10.2 48.94 284.89 Tm (VT, )Tj EMC ET BT /T1_0 1 Tf 0.0038 Tc 10.2 0 0 10.2 68.98 284.89 Tm (suggests )Tj 0.0351 Tc 4.012 0 Td (that )Tj 0.0029 Tc 2.212 0 Td (the )Tj 0.0113 Tc 1.788 0 Td (mechanisms )Tj -0.0065 Tc 5.641 0 Td (involved )Tj -0.035 Tc 9.9195 0 0 10.2 250 284.89 Tm (in )Tj 0.0265 Tc 10.2 0 0 10.2 263.5 284.89 Tm (the )Tj 0.188 0.192 0.18 rg 0.0237 Tc -21.034 -1.083 Td (respiratory )Tj 0.271 0.271 0.259 rg 0.0357 Tc 5.026 0 Td (adaptation )Tj 0.0253 Tc 4.996 0 Td (to )Tj 0.0383 Tc 1.321 0 Td (both )Tj 0.0232 Tc 2.342 0 Td (drugs )Tj 0 Tc 2.776 0 Td (a)Tj 0.118 0.118 0.106 rg 0.526 0 Td (r)Tj 0.271 0.271 0.259 rg 0.32 0 Td (e )Tj 0.0029 Tc 0.95 0 Td (the )Tj 0.0073 Tc 1.682 0 Td (same. )Tj 0.0095 Tc -19.958 -1.081 Td (Studies )Tj 0.188 0.192 0.18 rg 0.0116 Tc 3.501 0 Td (using )Tj -0.0106 Tc 2.721 0 Td (local )Tj 0.271 0.271 0.259 rg 0.0045 Tc 2.446 0 Td (airway )Tj 0.0303 Tc 3.247 0 Td (anaest)Tj 0.118 0.118 0.106 rg 0 Tc 2.691 0 Td (h)Tj 0.271 0.271 0.259 rg 0.0069 Tc 0.508 0 Td (esia )Tj 0.0001 Tc 2.08 0 Td (have )Tj 0.0134 Tc 2.344 0 Td (clearly )Tj 0.0124 Tc -19.533 -1.035 Td (shown )Tj 0.05 Tc 10.215 0 0 10.2 79.66 252.25 Tm (that)Tj 0.384 0.384 0.372 rg 0 Tc 10.2 0 0 10.2 96.8 252.25 Tm (, )Tj 0.188 0.192 0.18 rg 0.0311 Tc 0.58 0 Td (under )Tj 0.271 0.271 0.259 rg 0.0052 Tc 2.727 0 Td (these )Tj 0.0267 Tc 2.344 0 Td (exper)Tj 0.118 0.118 0.106 rg 0 Tc 2.309 0 Td (i)Tj 0.271 0.271 0.259 rg 0.0316 Tc 0.194 0 Td (mental )Tj 0.0259 Tc 3.192 0 Td (conditions)Tj 0.384 0.384 0.372 rg 0 Tc 4.418 0 Td (, )Tj 0.271 0.271 0.259 rg 0.0265 Tc 0.578 0 Td (the )Tj 0.0001 Tc -21.034 -1.082 Td (role )Tj 0.05 Tc 11.1292 0 0 10.2 71.89 241.21 Tm (of )Tj 0.0139 Tc 10.2 0 0 10.2 87.74 241.21 Tm (airway )Tj 0.0163 Tc 3.49 0 Td (vaga)Tj 0.118 0.118 0.106 rg 0 Tc 1.97 0 Td (l )Tj 0.271 0.271 0.259 rg 0.0413 Tc 0.892 0 Td (end)Tj 0.118 0.118 0.106 rg 0 Tc 1.556 0 Td (i)Tj 0.271 0.271 0.259 rg 0.013 Tc 0.242 0 Td (ngs )Tj 0.188 0.192 0.18 rg -0.035 Tc 9.9195 0 0 10.2 192.4 241.21 Tm (in )Tj 0.271 0.271 0.259 rg 0.0355 Tc 10.2 0 0 10.2 207.34 241.21 Tm (modulat)Tj 0.118 0.118 0.106 rg -0.0079 Tc 3.524 0 Td (in)Tj 0.271 0.271 0.259 rg 0 Tc 0.799 0 Td (g )Tj 0.0265 Tc 1.183 0 Td (the )Tj 0.019 Tc -21.034 -1.083 Td (respiratory )Tj 0.0114 Tc 5.365 0 Td (response )Tj -0.035 Tc 10.1489 0 0 10.2 148.24 230.16 Tm (is )Tj 0.0045 Tc 10.2 0 0 10.2 163.06 230.16 Tm (significant )Tj -0.035 Tc 9.4074 0 0 10.2 214.81 230.16 Tm ([3]. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0257 Tc 10.2 0 0 10.2 236.06 230.16 Tm (One )Tj EMC ET BT /T1_0 1 Tf 0.0229 Tc 10.2 0 0 10.2 261.4988 230.16 Tm (can )Tj 0.0144 Tc -20.839 -1.081 Td (therefore )Tj 0.0188 Tc 4.416 0 Td (conclude )Tj 0.05 Tc 10.215 0 0 10.2 138.7 219.13 Tm (that )Tj 0.0265 Tc 10.2 0 0 10.2 163.18 219.13 Tm (the )Tj 0.0281 Tc 1.965 0 Td (stimulat)Tj 0.118 0.118 0.106 rg 0 Tc 3.394 0 Td (i)Tj 0.271 0.271 0.259 rg -0.0085 Tc 0.289 0 Td (ng )Tj -0.0081 Tc 1.684 0 Td (effect )Tj 0.05 Tc 10.5727 0 0 10.2 267.74 219.13 Tm (of )Tj 0 Tc 10.2 0 0 10.2 48.95 208.09 Tm (h)Tj 0.118 0.118 0.106 rg 0.511 0 Td (i)Tj 0.271 0.271 0.259 rg 0.0199 Tc 0.229 0 Td (stamine )Tj 0.037 Tc 3.627 0 Td (and )Tj 0.0136 Tc 1.937 0 Td (methylchol)Tj 0.118 0.118 0.106 rg 0 Tc 4.606 0 Td (i)Tj 0.271 0.271 0.259 rg 0.0015 Tc 0.336 0 Td (ne )Tj 0.05 Tc 10.7226 0 0 10.2 177.02 208.09 Tm (on )Tj 0.017 Tc 10.2 0 0 10.2 191.98 208.09 Tm (these )Tj 0.013 Tc 2.542 0 Td (receptors )Tj -0.0218 Tc 4.188 0 Td (was )Tj 0.188 0.192 0.18 rg 0.0077 Tc -20.807 -1.036 Td (identical )Tj 0.271 0.271 0.259 rg 0.0192 Tc 4.232 0 Td (for )Tj 0.0383 Tc 1.941 0 Td (both )Tj 0.0027 Tc 2.585 0 Td (types )Tj 0.05 Tc 11.1292 0 0 10.2 166.45 197.52 Tm (of )Tj 0.0204 Tc 10.2 0 0 10.2 182.41 197.52 Tm (bronchospasm. )Tj 0.0068 Tc 6.992 0 Td (Since )Tj 0.0111 Tc -20.124 -1.081 Td (recent )Tj 0.05 Tc 10.377 0 0 10.2 77.18 186.49 Tm (data )Tj 0.0065 Tc 10.2 0 0 10.2 99.7 186.49 Tm (suggest )Tj 0.05 Tc 10.215 0 0 10.2 134.38 186.49 Tm (that )Tj 0.0147 Tc 10.2 0 0 10.2 154.96 186.49 Tm (inhaled )Tj 0 Tc 3.395 0 Td (h)Tj 0.118 0.118 0.106 rg 0.558 0 Td (i)Tj 0.271 0.271 0.259 rg 0.0277 Tc 0.229 0 Td (stamine )Tj 0.0183 Tc 3.636 0 Td (has )Tj 0.0084 Tc 1.732 0 Td (direct )Tj 0.0237 Tc -20.004 -1.083 Td (stimulating )Tj -0.0088 Tc 5.085 0 Td (effects )Tj 0.05 Tc 10.2564 0 0 10.2 131.42 175.44 Tm (on )Tj 0.0139 Tc 10.2 0 0 10.2 146.78 175.44 Tm (airway )Tj 0.0242 Tc 3.296 0 Td (irritant )Tj 0.013 Tc 3.395 0 Td (receptors )Tj -0.0349 Tc 4.212 0 Td ([26], )Tj 0.0265 Tc -20.542 -1.081 Td (the )Tj 0.0226 Tc 1.698 0 Td (present )Tj -0.0136 Tc 3.517 0 Td (findings )Tj -0.0022 Tc 3.721 0 Td (imply )Tj 0.05 Tc 10.215 0 0 10.2 167.98 164.41 Tm (that )Tj 0.0105 Tc 10.2 0 0 10.2 189.5 164.41 Tm (only )Tj 0.013 Tc 2.315 0 Td (receptors )Tj ET BT /Suspect <>BDC 0.188 0.192 0.18 rg /T1_0 1 Tf 0.0146 Tc 10.2 0 0 10.2 256.2386 164.41 Tm (indi\255)Tj EMC ET BT 0.271 0.271 0.259 rg /T1_0 1 Tf -0.0028 Tc 10.2 0 0 10.2 48.4646 153.3736 Tm (rectly )Tj 0.0216 Tc 2.67 0 Td (stimulated )Tj 0.0045 Tc 4.718 0 Td (via )Tj 0.0139 Tc 1.592 0 Td (airway )Tj 0.0282 Tc 3.196 0 Td (smooth )Tj -0.0002 Tc 3.494 0 Td (muscle )Tj 0.0262 Tc 3.192 0 Td (contrac\255)Tj 0.0161 Tc -18.863 -1.036 Td (tion )Tj 0 Tc 2.122 0 Td (p)Tj 0.118 0.118 0.106 rg 0.507 0 Td (l)Tj 0.271 0.271 0.259 rg 0.0092 Tc 0.234 0 Td (ay )Tj 0 Tc 1.459 0 Td (a )Tj 0.0001 Tc 0.95 0 Td (role )Tj -0.0079 Tc 2.017 0 Td (in )Tj 0.0265 Tc 1.229 0 Td (the )Tj 0.0042 Tc 1.742 0 Td (regu)Tj 0.118 0.118 0.106 rg 0 Tc 1.827 0 Td (l)Tj 0.271 0.271 0.259 rg 0.05 Tc 10.7518 0 0 10.2 174.61 142.8 Tm (at)Tj 0.118 0.118 0.106 rg 0 Tc 10.2 0 0 10.2 182.8 142.8 Tm (i)Tj 0.271 0.271 0.259 rg 0.0086 Tc 0.28 0 Td (on )Tj 0.05 Tc 11.1292 0 0 10.2 201.01 142.8 Tm (of )Tj 0.0029 Tc 10.2 0 0 10.2 214.54 142.8 Tm (the )Tj 0.0413 Tc 1.698 0 Td (pattern )Tj 0.05 Tc 11.1292 0 0 10.2 267.25 142.8 Tm (of )Tj 0.0178 Tc 10.2 0 0 10.2 48.97 131.76 Tm (breathing )Tj 0.0134 Tc 4.554 0 Td (and )Tj 0.0066 Tc 2.165 0 Td (drive )Tj -0.035 Tc 9.9195 0 0 10.2 145.36 131.76 Tm (in )Tj 0.0089 Tc 10.2 0 0 10.2 159.76 131.76 Tm (induced )Tj 0.188 0.192 0.18 rg 0.0321 Tc 3.915 0 Td (bronchospasm )Tj 0.271 0.271 0.259 rg -0.0079 Tc 6.721 0 Td (in )Tj 0.0091 Tc -21.546 -1.082 Td (normals. )Tj 0.188 0.192 0.18 rg 0.0113 Tc 4.322 0 Td (They )Tj 0.271 0.271 0.259 rg 0.0017 Tc 2.823 0 Td (confirm )Tj 0.05 Tc 10.5338 0 0 10.2 161.66 120.72 Tm (our )Tj 0.026 Tc 10.2 0 0 10.2 183.38 120.72 Tm (previou)Tj 0.384 0.384 0.372 rg 0 Tc 3.184 0 Td (s )Tj 0.271 0.271 0.259 rg 0.05 Tc 10.377 0 0 10.2 226.94 120.72 Tm (data )Tj 0.0116 Tc 10.2 0 0 10.2 253.92 120.72 Tm (using )Tj -0.0027 Tc -20.149 -1.082 Td (invasive )Tj 0.0377 Tc 3.618 0 Td (standard )Tj 0.188 0.192 0.18 rg 0.019 Tc 4.06 0 Td (respiratory )Tj 0.271 0.271 0.259 rg 0.0152 Tc 4.884 0 Td (equipments. )Tj 0.0359 Tc -11.622 -1.035 Td (To )Tj 0.05 Tc 10.5338 0 0 10.2 73.82 99.12 Tm (our )Tj 0.0027 Tc 10.2 0 0 10.2 93.1 99.12 Tm (knowledge, )Tj 0.0029 Tc 5.129 0 Td (the )Tj 0.0236 Tc 1.639 0 Td (opening )Tj 0.05 Tc 10.5727 0 0 10.2 200.54 99.12 Tm (of )Tj 0.0131 Tc 10.2 0 0 10.2 213.01 99.12 Tm (epithelial )Tj 0.0134 Tc 4.244 0 Td (tight )Tj 0.0306 Tc 4.402 64.33 Td (junctions )Tj 0.0029 Tc 4.437 0 Td (assoc)Tj 0.118 0.118 0.106 rg 0 Tc 2.214 0 Td (i)Tj 0.271 0.271 0.259 rg 0.0297 Tc 0.233 0 Td (ated )Tj 0.0212 Tc 2.362 0 Td (with )Tj 0.0186 Tc 2.34 0 Td (smoking )Tj 0.0183 Tc 4.107 0 Td (has )Tj 0.0108 Tc 1.929 0 Td (never )Tj 0.002 Tc 2.873 0 Td (been )Tj -0.0059 Tc -20.434 -1.035 Td (definitely )Tj 0.0179 Tc 4.047 0 Td (documented )Tj -0.035 Tc 9.9195 0 0 10.2 397.36 744.73 Tm (in )Tj 0.019 Tc 10.2 0 0 10.2 407.99 744.73 Tm (humans)Tj 0.384 0.384 0.372 rg 0 Tc 3.227 0 Td (. )Tj 0.188 0.192 0.18 rg 0.05 Tc 10.2656 0 0 10.2 445.35 744.73 Tm (The )Tj 0.271 0.271 0.259 rg -0.0031 Tc 10.2 0 0 10.2 464.53 744.73 Tm (fact )Tj 0.05 Tc 10.5068 0 0 10.2 482.85 744.73 Tm (that )Tj 0.0247 Tc 10.2 0 0 10.2 501.94 744.73 Tm (smoke )Tj 0.0286 Tc -19.618 -1.083 Td (inhalation )Tj 0.0038 Tc 4.518 0 Td (induces )Tj 0.05 Tc 10.2654 0 0 10.2 381.98 733.68 Tm (an )Tj 0.188 0.192 0.18 rg -0.0011 Tc 10.2 0 0 10.2 395.44 733.68 Tm (increase )Tj 0.271 0.271 0.259 rg -0.0079 Tc 3.529 0 Td (in )Tj 0.0078 Tc 1.032 0 Td (epithelial )Tj 0.0171 Tc 4.107 0 Td (permeabil\255)Tj 0.188 0.192 0.18 rg -0.0248 Tc -17.798 -1.081 Td (ity )Tj 0.271 0.271 0.259 rg 0.0192 Tc 1.221 0 Td (for )Tj 0.0151 Tc 1.422 0 Td (histamine )Tj 0.0391 Tc 4.181 0 Td (in )Tj 0.0363 Tc 0.994 0 Td (man )Tj 0.0261 Tc 2.016 0 Td (as )Tj -0.0079 Tc 1.037 0 Td (in )Tj 0.0175 Tc 0.986 0 Td (animals )Tj 0.0196 Tc 3.384 0 Td (strongly )Tj 0.0038 Tc 3.624 0 Td (suggests )Tj 0.0351 Tc -18.859 -1.035 Td (that )Tj -0.0202 Tc 1.876 0 Td (it )Tj -0.0028 Tc 0.807 0 Td (really )Tj 0.0095 Tc 2.532 0 Td (occurs )Tj 0.188 0.192 0.18 rg -0.035 Tc 9.9277 0 0 10.2 384.72 712.09 Tm ([27\). )Tj 0.271 0.271 0.259 rg 0.0293 Tc 10.2 0 0 10.2 405.03 712.09 Tm (Thus )Tj 0.0416 Tc 2.305 0 Td (one )Tj 0.0229 Tc 1.741 0 Td (can )Tj 0.0164 Tc 1.694 0 Td (assume )Tj 0.0351 Tc 3.302 0 Td (that )Tj 0.0265 Tc 1.882 0 Td (the )Tj 0.0303 Tc -21.032 -1.082 Td (bronch)Tj 0.118 0.118 0.106 rg 0 Tc 2.956 0 Td (i)Tj 0.271 0.271 0.259 rg -0.035 Tc 9.9712 0 0 10.2 334.94 701.05 Tm (al )Tj 0.0117 Tc 10.2 0 0 10.2 345.58 701.05 Tm (mucosa )Tj 0.05 Tc 11.1292 0 0 10.2 380.53 701.05 Tm (of )Tj 0.0137 Tc 10.2 0 0 10.2 392.5 701.05 Tm (smokers )Tj -0.035 Tc 9.3682 0 0 10.2 430.48 701.05 Tm (is )Tj 0.118 0.118 0.106 rg 0 Tc 10.2 0 0 10.2 439.6 701.05 Tm (i)Tj 0.271 0.271 0.259 rg 0.289 0 Td [(n )-41(a )]TJ 0.023 Tc 1.599 0 Td (more )Tj 0.0199 Tc 2.438 0 Td (favourable )Tj 0.0223 Tc -17.834 -1.083 Td (condit)Tj 0.118 0.118 0.106 rg 0 Tc 2.637 0 Td (i)Tj 0.271 0.271 0.259 rg 0.0086 Tc 0.28 0 Td (on )Tj 0.0192 Tc 1.411 0 Td (for )Tj 0.0178 Tc 1.507 0 Td (direct )Tj 0.0073 Tc 2.682 0 Td (chem)Tj 0.118 0.118 0.106 rg 0 Tc 2.214 0 Td (i)Tj 0.271 0.271 0.259 rg 0.0403 Tc 0.233 0 Td (cal )Tj 0.0224 Tc 1.506 0 Td (action )Tj 0.05 Tc 11.1292 0 0 10.2 458.77 690 Tm (of )Tj 0.0147 Tc 10.2 0 0 10.2 471.28 690 Tm (inhaled )Tj 0.0232 Tc 3.386 0 Td (drugs )Tj 0.05 Tc 10.2564 0 0 10.2 301.82 679.44 Tm (on )Tj 0.0018 Tc 10.2 0 0 10.2 316.78 679.44 Tm (vagal )Tj 0.0185 Tc 2.579 0 Td (endings )Tj 0.0235 Tc 3.632 0 Td (than )Tj 0.05 Tc 10.215 0 0 10.2 403.18 679.44 Tm (that )Tj 11.1292 0 0 10.2 424.21 679.44 Tm (of )Tj 0.0029 Tc 10.2 0 0 10.2 437.26 679.44 Tm (the )Tj 0.0193 Tc 1.695 0 Td (nonsmokers. )Tj 0.05 Tc 10.2656 0 0 10.2 512.55 679.44 Tm (The )Tj 0.0083 Tc 10.2 0 0 10.2 301.82 668.41 Tm (absence )Tj 0.05 Tc 10.5727 0 0 10.2 341.18 668.41 Tm (of )Tj 0.037 Tc 10.2 0 0 10.2 356.06 668.41 Tm (any )Tj -0.0043 Tc 2.118 0 Td (difference )Tj -0.0079 Tc 4.614 0 Td (in )Tj 0.019 Tc 1.466 0 Td (respiratory )Tj 0.0181 Tc 5.176 0 Td (response )Tj -0.004 Tc -18.68 -1.083 Td (between )Tj 0.0151 Tc 4.045 0 Td (histamine )Tj 0.0134 Tc 4.65 0 Td (and )Tj 0.0144 Tc 2.173 0 Td (methylcholine )Tj -0.0079 Tc 6.535 0 Td (in )Tj 0.0294 Tc 1.406 0 Td (smokers )Tj 0.188 0.192 0.18 rg 0.0221 Tc -18.821 -1.081 Td (further )Tj 0.271 0.271 0.259 rg 0.0305 Tc 3.668 0 Td (supports )Tj 0.05 Tc 10.5338 0 0 10.2 383.9 646.33 Tm (our )Tj 0.0149 Tc 10.2 0 0 10.2 406.46 646.33 Tm (conclusions )Tj 0.0478 Tc 5.647 0 Td (about )Tj 0.017 Tc 3.202 0 Td (indirect )Tj 0.0057 Tc -19.106 -1.082 Td (involvement )Tj 0.05 Tc 11.1292 0 0 10.2 359.41 635.29 Tm (of )Tj 0.0265 Tc 10.2 0 0 10.2 373.9 635.29 Tm (the )Tj 0.0018 Tc 1.788 0 Td (vagal )Tj 0.0045 Tc 2.769 0 Td (airway )Tj 0.384 0.384 0.372 rg 0 Tc 3.343 0 Td (i)Tj 0.271 0.271 0.259 rg 0.0326 Tc 0.289 0 Td (rritant )Tj 0.0189 Tc 3.2 0 Td (receptors )Tj 0.0046 Tc -18.507 -1.035 Td (suggested )Tj -0.035 Tc 10.0482 0 0 10.2 346.09 624.73 Tm (by )Tj 0.0029 Tc 10.2 0 0 10.2 359.98 624.73 Tm (the )Tj 0.0447 Tc 1.545 0 Td (data )Tj 0.0391 Tc 2.167 0 Td (in )Tj 0.0334 Tc 1.136 0 Td (nonsmoker)Tj 0.384 0.384 0.372 rg 0 Tc 4.693 0 Td (s)Tj 0.271 0.271 0.259 rg 0.417 0 Td (. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.2894 0 0 10.2 311.42 613.68 Tm (Our )Tj EMC ET BT /T1_0 1 Tf 0.0295 Tc 10.2 0 0 10.2 336.82 613.68 Tm (study )Tj 0.0166 Tc 3.059 0 Td (shows )Tj 0.05 Tc 10.215 0 0 10.2 402.7 613.68 Tm (that )Tj 0.0265 Tc 10.2 0 0 10.2 427.66 613.68 Tm (the )Tj 0.0296 Tc 2.121 0 Td (breathing )Tj 0.0413 Tc 4.801 0 Td (pattern )Tj 0.0106 Tc -19.306 -1.081 Td (associated )Tj 0.0212 Tc 4.526 0 Td (with )Tj 0.188 0.192 0.18 rg 0.0193 Tc 2.167 0 Td (bronchospasm )Tj 0.118 0.118 0.106 rg 0 Tc 6.297 0 Td (i)Tj 0.271 0.271 0.259 rg 0.229 0 Td (s )Tj 0.0265 Tc 0.671 0 Td (the )Tj 0.0146 Tc 1.541 0 Td (same )Tj 0.0391 Tc 2.359 0 Td (in )Tj 0.0284 Tc 1.076 0 Td (smoker)Tj 0.384 0.384 0.372 rg 0 Tc 3.106 0 Td (s )Tj 0.271 0.271 0.259 rg 0.0261 Tc -21.973 -1.082 Td (as )Tj -0.0079 Tc 1.32 0 Td (in )Tj 0.0231 Tc 1.23 0 Td (nonsmokers)Tj 0.384 0.384 0.372 rg 0 Tc 5.068 0 Td (, )Tj 0.271 0.271 0.259 rg -0.0007 Tc 0.674 0 Td (while )Tj 0.0029 Tc 2.681 0 Td (the )Tj -0.0067 Tc 1.695 0 Td (way )Tj 0.0216 Tc 2.058 0 Td (smokers )Tj 0.05 Tc 10.2044 0 0 10.2 491.42 591.61 Tm (adapt )Tj -0.0217 Tc 10.2 0 0 10.2 520.78 591.61 Tm (to )Tj 0.0236 Tc -21.456 -1.035 Td (bronchospasm )Tj -0.0079 Tc 6.532 0 Td (in )Tj 0.0105 Tc 1.229 0 Td (terms )Tj 0.05 Tc 10.5727 0 0 10.2 409.34 581.05 Tm (of )Tj 0.019 Tc 10.2 0 0 10.2 422.87 581.05 Tm (respiratory )Tj 0.0184 Tc 4.979 0 Td (drive )Tj -0.0018 Tc 2.588 0 Td (differs)Tj 0.384 0.384 0.372 rg 0 Tc 2.625 0 Td (. )Tj 0.271 0.271 0.259 rg 0.0174 Tc -22.104 -1.083 Td (Indeed, )Tj 0.009 Tc 3.772 0 Td (unlike )Tj 0.0231 Tc 3.152 0 Td (nonsmokers)Tj 0.384 0.384 0.372 rg 0 Tc 5.021 0 Td (, )Tj 0.271 0.271 0.259 rg 0.0254 Tc 0.908 0 Td (their )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 11.3696 0 0 10.2 457.89 570 Tm (Yr)Tj 0.384 0.384 0.372 rg 0 Tc 10.2 0 0 10.2 470.4 570 Tm (/)Tj 0.188 0.192 0.18 rg -0.0324 Tc 0.321 0 Td (TI )Tj EMC ET BT 0.271 0.271 0.259 rg /T1_0 1 Tf 0.0198 Tc 10.2 0 0 10.2 489.0252 570 Tm (does )Tj 0.188 0.192 0.18 rg 0.0455 Tc 2.55 0 Td (not )Tj 0.271 0.271 0.259 rg 0.0182 Tc -20.95 -1.081 Td (co)Tj 0.118 0.118 0.106 rg 0 Tc 0.997 0 Td (r)Tj 0.271 0.271 0.259 rg 0.0086 Tc 0.376 0 Td (relate )Tj -0.0217 Tc 2.681 0 Td (to )Tj 0.0029 Tc 1.176 0 Td (the )Tj 0.0078 Tc 1.592 0 Td (decrease )Tj -0.035 Tc 9.9195 0 0 10.2 410.32 558.97 Tm (in )Tj 0.0293 Tc 10.2 0 0 10.2 421.88 558.97 Tm (FEV )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 6.2 0 0 6.2 441.87 557.05 Tm (1)Tj 0.384 0.384 0.372 rg 0.787 0.31 Td (. )Tj EMC ET BT 0.271 0.271 0.259 rg /T1_0 1 Tf 0.0252 Tc 10.2 0 0 10.2 452.07 558.97 Tm (This )Tj -0.035 Tc 10.1489 0 0 10.2 474.64 558.97 Tm (is )Tj 0.0155 Tc 10.2 0 0 10.2 484.24 558.97 Tm (intriguing, )Tj -0.0008 Tc -17.935 -1.083 Td (since )Tj 0.0226 Tc 2.462 0 Td (both )Tj 0.0084 Tc 2.257 0 Td (responses )Tj 0 Tc 4.321 0 Td (a)Tj 0.118 0.118 0.106 rg 0.526 0 Td (r)Tj 0.271 0.271 0.259 rg 0.32 0 Td (e )Tj 0.0073 Tc 0.856 0 Td (vagally-mediated. )Tj 0 Tc 7.718 0 Td (A )Tj 0.0236 Tc 1.133 0 Td (partial )Tj 0.0207 Tc -19.589 -1.035 Td (explanation )Tj 0.0464 Tc 5.272 0 Td (can )Tj -0.035 Tc 10.1515 0 0 10.2 374.89 537.36 Tm (be )Tj 0.0237 Tc 10.2 0 0 10.2 388.21 537.36 Tm (found )Tj 0.0391 Tc 2.874 0 Td (in )Tj 0.0265 Tc 1.229 0 Td (the )Tj -0.0031 Tc 1.685 0 Td (fact )Tj 0.05 Tc 10.215 0 0 10.2 467.02 537.36 Tm (that )Tj 0.0237 Tc 10.2 0 0 10.2 488.65 537.36 Tm (breathing )Tj 0.188 0.192 0.18 rg 0.0335 Tc -18.352 -1.081 Td (pattern )Tj 0.271 0.271 0.259 rg 0.0259 Tc 3.385 0 Td (regulation )Tj 0.188 0.192 0.18 rg -0.0041 Tc 4.699 0 Td (involves )Tj 0.271 0.271 0.259 rg 0.0383 Tc 3.774 0 Td (both )Tj 0.031 Tc 2.344 0 Td (irritant )Tj 0.037 Tc 3.339 0 Td (and )Tj 0.0311 Tc 1.925 0 Td (stretch )Tj 0.0099 Tc -19.47 -1.082 Td (receptors, )Tj -0.0125 Tc 4.424 0 Td (while )Tj 0.0315 Tc 2.497 0 Td (probably )Tj 0.0105 Tc 4.129 0 Td (only )Tj 0.0265 Tc 2.125 0 Td (the )Tj 0.0171 Tc 1.638 0 Td (former )Tj 0.0333 Tc 3.154 0 Td (contribute )Tj 0.0253 Tc -17.969 -1.082 Td (to )Tj 0.0265 Tc 1.318 0 Td (the )Tj 0.0066 Tc 1.733 0 Td (drive )Tj 0.016 Tc 2.541 0 Td (changes )Tj 0.0119 Tc 3.765 0 Td (observed )Tj 0.188 0.192 0.18 rg -0.0079 Tc 4.19 0 Td (in )Tj 0.271 0.271 0.259 rg 0 Tc 1.279 0 Td (b)Tj 0.118 0.118 0.106 rg 0.516 0 Td (r)Tj 0.271 0.271 0.259 rg 0.0416 Tc 0.368 0 Td (onc)Tj 0.118 0.118 0.106 rg 0.0392 Tc 1.515 0 Td (ho)Tj 0.271 0.271 0.259 rg 0.0171 Tc 1.07 0 Td (spasm)Tj 0.384 0.384 0.372 rg 0 Tc 2.628 0 Td (. )Tj 0.271 0.271 0.259 rg /T1_1 1 Tf 0.05 Tc 12.2371 0 0 9.7 521.9 504.25 Tm (It )Tj /T1_0 1 Tf -0.0087 Tc 10.2 0 0 10.2 301.33 493.21 Tm (follows )Tj 0.05 Tc 10.215 0 0 10.2 335.02 493.21 Tm (that )Tj /T1_1 1 Tf 0.0226 Tc 10.1 0 0 10.1 355 493.21 Tm (in )Tj /T1_0 1 Tf 0.0264 Tc 10.2 0 0 10.2 366.14 493.21 Tm (aysmptomatic )Tj 0.0216 Tc 6.161 0 Td (smokers )Tj 0.0113 Tc 3.765 0 Td (some )Tj 0.188 0.192 0.18 rg 0.0058 Tc 2.451 0 Td (dysfunc\255)Tj 0.271 0.271 0.259 rg 0.0161 Tc -18.722 -1.035 Td (tion )Tj 0.05 Tc 11.1292 0 0 10.2 321.97 482.65 Tm (of )Tj 0.031 Tc 10.2 0 0 10.2 334.48 482.65 Tm (irritant )Tj 0.0166 Tc 3.348 0 Td (receptor)Tj 0.384 0.384 0.372 rg 0 Tc 3.375 0 Td (s )Tj 0.271 0.271 0.259 rg 0.0183 Tc 0.766 0 Td (has )Tj 0.05 Tc 10.4772 0 0 10.2 428.61 482.65 Tm (to )Tj -0.035 Tc 10.1515 0 0 10.2 441.61 482.65 Tm (be )Tj 0.0038 Tc 10.2 0 0 10.2 455.06 482.65 Tm (present. )Tj 0 Tc 3.573 0 Td (A )Tj 0.0205 Tc 1.13 0 Td (recent )Tj 0.0295 Tc -19.777 -1.082 Td (study )Tj -0.035 Tc 10.0482 0 0 10.2 327.37 471.61 Tm (by )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0408 Tc 7.8001 0 0 7.8001 340.14 471.61 Tm (PARDY )Tj EMC ET BT /T1_2 1 Tf 0.05 Tc 10.1514 0 0 9.9 370.47 471.61 Tm (et )Tj -0.0242 Tc 9.9 0 0 9.9 381.06 471.61 Tm (al. )Tj /T1_0 1 Tf 0.0048 Tc 10.2 0 0 10.2 393.94 471.61 Tm (shows )Tj 0.05 Tc 10.215 0 0 10.2 422.38 471.61 Tm (that )Tj 0.188 0.192 0.18 rg 0.0151 Tc 10.2 0 0 10.2 442.07 471.61 Tm (histamine )Tj 0.271 0.271 0.259 rg 0.0286 Tc 4.228 0 Td (inhalation )Tj -0.008 Tc -18.018 -1.083 Td (modifies )Tj 0.0029 Tc 4.047 0 Td (the )Tj 0.0335 Tc 1.839 0 Td (pattern )Tj 0.05 Tc 11.1292 0 0 10.2 397.81 460.56 Tm (of )Tj 0.0237 Tc 10.2 0 0 10.2 412.81 460.56 Tm (breathing )Tj 0.188 0.192 0.18 rg -0.0079 Tc 4.509 0 Td (in )Tj 0.0199 Tc 1.419 0 Td (normocapnic )Tj 0.271 0.271 0.259 rg 0.0295 Tc -16.903 -1.081 Td (chronic )Tj 0.0193 Tc 3.765 0 Td (obstructive )Tj 0.0147 Tc 5.329 0 Td (patients )Tj 0.0252 Tc 3.903 0 Td (without )Tj -0.0011 Tc 3.85 0 Td (affecting )Tj 0.0029 Tc 4.243 0 Td (the )Tj 0.0066 Tc -21.09 -1.082 Td (drive )Tj 0.0261 Tc 2.588 0 Td (as )Tj 0.0178 Tc 1.317 0 Td (exp)Tj 0.118 0.118 0.106 rg 0 Tc 1.516 0 Td (r)Tj 0.271 0.271 0.259 rg -0.0067 Tc 0.367 0 Td (essed )Tj -0.0209 Tc 2.636 0 Td (as )Tj -0.035 Tc 9.2996 0 0 10.2 400.3 438.49 Tm (VT)Tj 0.384 0.384 0.372 rg 0 Tc 10.2 0 0 10.2 412.32 438.49 Tm (/)Tj 0.271 0.271 0.259 rg -0.0324 Tc 0.321 0 Td (TI )Tj -0.035 Tc 9.7536 0 0 10.2 429.84 438.49 Tm ([28])Tj 0.384 0.384 0.372 rg 0 Tc 10.2 0 0 10.2 445.71 438.49 Tm (. )Tj 0.271 0.271 0.259 rg 0.0387 Tc 0.723 0 Td (Furthermore)Tj 0.384 0.384 0.372 rg 0 Tc 5.4 0 Td (, )Tj 0.271 0.271 0.259 rg 0.0265 Tc 0.72 0 Td (the )Tj 0.0017 Tc -20.987 -1.035 Td (recent )Tj 0.0178 Tc 2.858 0 Td (study )Tj -0.0022 Tc 2.65 0 Td (by )Tj ET BT /Suspect <>BDC 0.188 0.192 0.18 rg /T1_0 1 Tf -0.035 Tc 8.723 0 0 10.2 371.43 427.93 Tm (OLIVEN )Tj EMC /Suspect <>BDC 0.271 0.271 0.259 rg /T1_2 1 Tf 0.0207 Tc 9.9 0 0 9.9 406.47 427.93 Tm (et )Tj EMC ET BT /T1_2 1 Tf 0 Tc 9.9 0 0 9.9 417.5382 427.93 Tm (a/. )Tj /T1_0 1 Tf -0.035 Tc 9.7536 0 0 10.2 431.76 427.93 Tm ([29] )Tj 0.0213 Tc 10.2 0 0 10.2 451.09 427.93 Tm (estab)Tj 0.118 0.118 0.106 rg 0 Tc 2.167 0 Td (l)Tj 0.271 0.271 0.259 rg -0.0013 Tc 0.236 0 Td (ishes )Tj 0.05 Tc 10.215 0 0 10.2 499.66 427.93 Tm (that )Tj 0.0391 Tc 10.2 0 0 10.2 520.24 427.93 Tm (in )Tj 0.0295 Tc -21.508 -1.082 Td (chronic )Tj 0.0193 Tc 3.435 0 Td (obstructive )Tj 0.188 0.192 0.18 rg 0.0088 Tc 4.989 0 Td (lung )Tj 0.271 0.271 0.259 rg 0.004 Tc 2.07 0 Td (disease, )Tj 0.0105 Tc 3.537 0 Td (methylcholine )Tj 0.188 0.192 0.18 rg 0.0202 Tc 6.159 0 Td (inha\255)Tj 0.271 0.271 0.259 rg 0.0188 Tc -20.142 -1.083 Td (lation )Tj -0.035 Tc 10.1489 0 0 10.2 330.16 405.84 Tm (is )Tj 0.0158 Tc 10.2 0 0 10.2 340.7 405.84 Tm (associated )Tj 0.0056 Tc 4.715 0 Td (with )Tj 0.05 Tc 10.2654 0 0 10.2 411.74 405.84 Tm (an )Tj 0.0123 Tc 10.2 0 0 10.2 426.64 405.84 Tm (increase )Tj 0.188 0.192 0.18 rg -0.0079 Tc 3.765 0 Td (in )Tj 0.271 0.271 0.259 rg 0.0066 Tc 1.222 0 Td (drive )Tj -0.0094 Tc 2.55 0 Td (which )Tj 0.0262 Tc -19.868 -1.081 Td (only )Tj 0.0125 Tc 2.259 0 Td (depends )Tj 0.05 Tc 10.2564 0 0 10.2 362.78 394.81 Tm (on )Tj 0.0265 Tc 10.2 0 0 10.2 378.22 394.81 Tm (the )Tj 0.0058 Tc 1.686 0 Td (chemical )Tj 0.0451 Tc 4.047 0 Td (cont)Tj 0.118 0.118 0.106 rg 0 Tc 1.891 0 Td (r)Tj 0.271 0.271 0.259 rg -0.0037 Tc 0.368 0 Td (ol )Tj 0.05 Tc 11.1292 0 0 10.2 472.21 394.81 Tm (of )Tj 0.188 0.192 0.18 rg 0.0194 Tc 10.2 0 0 10.2 485.29 394.81 Tm (breathing. )Tj 0.0196 Tc -18.127 -1.083 Td (These )Tj 0.271 0.271 0.259 rg 0.05 Tc 10.377 0 0 10.2 328.22 383.76 Tm (data )Tj 0.0056 Tc 10.2 0 0 10.2 349.82 383.76 Tm (clearly )Tj 0.188 0.192 0.18 rg -0.0022 Tc 3.061 0 Td (imply )Tj 0.271 0.271 0.259 rg 0.0344 Tc 2.641 0 Td (that, )Tj -0.0079 Tc 2.159 0 Td (in )Tj 0.0223 Tc 1.088 0 Td (terms )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 11.1292 0 0 10.2 467.41 383.76 Tm (of )Tj EMC ET BT 0.188 0.192 0.18 rg /T1_0 1 Tf 0.0024 Tc 10.2 0 0 10.2 478.94 383.76 Tm (drive, )Tj 0.271 0.271 0.259 rg 0.0136 Tc 2.643 0 Td (vagal )Tj 0.0139 Tc -20.102 -1.034 Td (airway )Tj 0.0189 Tc (receptors )Tj 0.05 Tc 10.6052 0 0 10.2 373.34 373.21 Tm (do )Tj 0.022 Tc 10.2 0 0 10.2 387.35 373.21 Tm (not )Tj -0.0022 Tc 1.634 0 Td (significantly )Tj 0.028 Tc 5.227 0 Td (contribute )Tj 0.0253 Tc 4.62 0 Td (to )Tj 0.0265 Tc 1.082 0 Td (the )Tj 0.041 Tc -21.043 -1.083 Td (adaptation )Tj 0.0253 Tc 4.808 0 Td (to )Tj 0.0292 Tc 1.075 0 Td (acute )Tj 0.188 0.192 0.18 rg 0.0167 Tc 2.449 0 Td (induced )Tj 0.271 0.271 0.259 rg 0.0236 Tc 3.538 0 Td (bronchospasm )Tj -0.0079 Tc 6.297 0 Td (in )Tj 0.05 Tc 10.3603 0 0 10.2 496.22 362.16 Tm (ch)Tj 0.118 0.118 0.106 rg 0 Tc 10.2 0 0 10.2 506.87 362.16 Tm (r)Tj 0.271 0.271 0.259 rg 0.0295 Tc 0.321 0 Td (onic )Tj 0.0193 Tc -20.518 -1.082 Td (obstructive )Tj 0.188 0.192 0.18 rg 0.0088 Tc 4.895 0 Td (lung )Tj 0.271 0.271 0.259 rg -0.0007 Tc 2.07 0 Td (disease)Tj 0.384 0.384 0.372 rg 0 Tc 2.954 0 Td (. )Tj 0.271 0.271 0.259 rg 0.05 Tc 10.2312 0 0 10.2 407 351.12 Tm (From )Tj 0.0029 Tc 10.2 0 0 10.2 433.9 351.12 Tm (the )Tj 0.0298 Tc 1.498 0 Td (above )Tj 0.0057 Tc 2.729 0 Td (analysis )Tj 0.0416 Tc 3.529 0 Td (one )Tj 0.0415 Tc -20.847 -1.081 Td (cou)Tj 0.118 0.118 0.106 rg 0 Tc 1.554 0 Td (l)Tj 0.271 0.271 0.259 rg 0.234 0 Td (d )Tj 0.0144 Tc 0.855 0 Td (therefore )Tj 0.0308 Tc 4.051 0 Td (propo)Tj 0.384 0.384 0.372 rg 0 Tc 2.478 0 Td (s)Tj 0.271 0.271 0.259 rg 0.379 0 Td (e )Tj 0.0265 Tc 0.715 0 Td (the )Tj 0.0169 Tc 1.554 0 Td (hypothesis )Tj 0.0351 Tc 4.705 0 Td (that)Tj 0.384 0.384 0.372 rg 0 Tc 1.633 0 Td (, )Tj 0.271 0.271 0.259 rg -0.035 Tc 9.9195 0 0 10.2 491.44 340.09 Tm (in )Tj 0.0111 Tc 10.2 0 0 10.2 502.07 340.09 Tm (young )Tj 0.0221 Tc -19.726 -1.082 Td (asymptomatic )Tj 0.0097 Tc 6.161 0 Td (smokers, )Tj 0.0113 Tc 4 0 Td (some )Tj 0.0154 Tc 2.4 0 Td (smoking-related )Tj 0.0162 Tc 7.063 0 Td (altera\255)Tj 0.009 Tc -19.616 -1.083 Td (tions )Tj 0.05 Tc 11.6856 0 0 10.2 323.89 318 Tm (of )Tj 0.0265 Tc 10.2 0 0 10.2 335.5 318 Tm (the )Tj 0.0117 Tc 1.553 0 Td (mucosa )Tj 0.05 Tc 11.1292 0 0 10.2 386.29 318 Tm (of )Tj 0.0029 Tc 10.2 0 0 10.2 397.9 318 Tm (the )Tj 0.0095 Tc 1.498 0 Td (airways )Tj 0.0313 Tc 3.435 0 Td (are )Tj 0.0106 Tc 1.553 0 Td (associated )Tj 0.0056 Tc 4.479 0 Td (with )Tj 0 Tc -20.479 -1.081 Td (a )Tj 0.0184 Tc 0.706 0 Td (dysfunction )Tj 0.05 Tc 11.1292 0 0 10.2 361.33 306.97 Tm (of )Tj 0.0006 Tc 10.2 0 0 10.2 372.94 306.97 Tm (vaga)Tj 0.118 0.118 0.106 rg 0 Tc 1.97 0 Td (l )Tj 0.188 0.192 0.18 rg 0.031 Tc 0.519 0 Td (irritant )Tj 0.271 0.271 0.259 rg 0.0189 Tc 3.207 0 Td (receptors)Tj 0.384 0.384 0.372 rg 0 Tc 3.891 0 Td (, )Tj 0.271 0.271 0.259 rg -0.0094 Tc 0.532 0 Td (which )Tj 0.0184 Tc 2.681 0 Td (might )Tj 0.0095 Tc -19.855 -1.035 Td (precede )Tj 0.0265 Tc 3.62 0 Td (the )Tj 0.0303 Tc 1.733 0 Td (appearance )Tj 0.05 Tc 11.1292 0 0 10.2 408.85 296.41 Tm (of )Tj 0.0295 Tc 10.2 0 0 10.2 422.3 296.41 Tm (chronic )Tj 0.0193 Tc 3.624 0 Td (obstructive )Tj -0.0003 Tc 5.141 0 Td (pul\255)Tj 0.188 0.192 0.18 rg 0.0397 Tc -20.71 -1.082 Td (monary )Tj 0.271 0.271 0.259 rg -0.0027 Tc 3.804 0 Td (disease. )Tj /T1_1 1 Tf 0.05 Tc 12.2371 0 0 9.7 377.42 285.37 Tm (It )Tj /T1_0 1 Tf 0.0184 Tc 10.2 0 0 10.2 390.22 285.37 Tm (might )Tj 0.0078 Tc 2.968 0 Td (be )Tj 0.0351 Tc 1.55 0 Td (that )Tj 0.0061 Tc 2.212 0 Td (this )Tj -0.035 Tc 10.1489 0 0 10.2 479.44 285.37 Tm (is )Tj 0.05 Tc 10.2654 0 0 10.2 491.42 285.37 Tm (an )Tj 0.0118 Tc 10.2 0 0 10.2 507.25 285.37 Tm (early )Tj 0.0219 Tc -20.274 -1.082 Td (manifestation )Tj 0.05 Tc 11.1292 0 0 10.2 363.73 274.33 Tm (of )Tj 0.0217 Tc 10.2 0 0 10.2 376.7 274.33 Tm (chronic )Tj 0.0172 Tc 3.634 0 Td (bronchitis)Tj 0.384 0.384 0.372 rg 0 Tc (, )Tj 0.271 0.271 0.259 rg 0.05 Tc 10.5727 0 0 10.2 463.58 274.33 Tm (or )Tj 0.0217 Tc 10.2 0 0 10.2 477.02 274.33 Tm (chronic )Tj 0.0123 Tc 3.576 0 Td (air\255)Tj 0.188 0.192 0.18 rg -0.0303 Tc -20.838 -1.083 Td (way )Tj 0.271 0.271 0.259 rg 0.0239 Tc 1.968 0 Td (obstruction. )Tj 0.188 0.192 0.18 rg -0.035 Tc 9.7895 0 0 9.8 394.51 232.09 Tm (References )Tj ET BT /Suspect <>BDC 0.271 0.271 0.259 rg /T1_1 1 Tf 0.05 Tc 8.7408 0 0 7.8001 301.2 215.76 Tm (I. )Tj EMC ET BT /T1_0 1 Tf 0.0403 Tc 8 0 0 8 314.85 215.76 Tm (Michoud )Tj 0.05 Tc 8.4293 0 0 8 350.36 215.76 Tm (MC)Tj 0.384 0.384 0.372 rg 0 Tc 8 0 0 8 364.2 215.76 Tm (, )Tj 0.271 0.271 0.259 rg 0.0334 Tc 0.851 0 Td (Pare )Tj 0.05 Tc 8.0365 0 0 8 390.68 215.76 Tm (PO, )Tj 0.0294 Tc 8 0 0 8 408.93 215.76 Tm (Boucher )Tj ET BT /Suspect <>BDC 0.188 0.192 0.18 rg /T1_0 1 Tf 0 Tc 8 0 0 8 442.522 215.76 Tm (R)Tj 0.384 0.384 0.372 rg 0.71 0 Td (, )Tj EMC /Suspect <>BDC 0.271 0.271 0.259 rg 0.0431 Tc 0.85 0 Td (Hogg )Tj EMC /Suspect <>BDC 0.0416 Tc 2.88 0 Td (JC. )Tj EMC /Suspect <>BDC 0.384 0.384 0.372 rg 0 Tc 1.974 0 Td (-)Tj EMC ET BT 0.271 0.271 0.259 rg /T1_0 1 Tf 0.0138 Tc 8 0 0 8 503.034 215.76 Tm (Airway )Tj 0.0168 Tc -25.32 -1.139 Td (responses )Tj 0 Tc 4.379 0 Td (t)Tj 0.384 0.384 0.372 rg 0.292 0 Td (o )Tj 0.271 0.271 0.259 rg 0.0251 Tc 0.909 0 Td (histamine )Tj 0.05 Tc 8.1466 0 0 8 380.56 206.65 Tm (and )Tj 0.0006 Tc 8 0 0 8 395.99 206.65 Tm (me1hylcholine )Tj -0.035 Tc 7.9356 0 0 8 446.34 206.65 Tm (in )Tj 0.0116 Tc 8 0 0 8 455.51 206.65 Tm (Ascaris )Tj 0.0464 Tc 3.348 0 Td (suum)Tj 0.384 0.384 0.372 rg 0 Tc 2.342 0 Td (-)Tj 0.271 0.271 0.259 rg 0.0112 Tc 0.301 0 Td (allergic )Tj 0.188 0.192 0.18 rg 0.0173 Tc -25.371 -1.08 Td (rhesus )Tj 0.271 0.271 0.259 rg 0.0292 Tc 2.94 0 Td (monkeys)Tj 0.384 0.384 0.372 rg 0 Tc 3.821 0 Td (. )Tj 0.271 0.271 0.259 rg /T1_3 1 Tf 7.4001 0 0 7.4001 358.49 198.01 Tm (J )Tj /T1_2 1 Tf 0.0409 Tc 7.9001 0 0 7.9001 365.4 198.01 Tm (Appl )Tj 0.0341 Tc 2.24 0 Td (Ph)Tj 0.384 0.384 0.372 rg 0 Tc 1.11 0 Td (y)Tj 0.271 0.271 0.259 rg 0.0269 Tc 0.527 0 Td (siol)Tj 0.384 0.384 0.372 rg 0 Tc 1.497 0 Td (: )Tj 0.271 0.271 0.259 rg 0.0203 Tc 0.633 0 Td (Respirat )Tj -0.002 Tc 3.828 0 Td (Environ )Tj 0.384 0.384 0.372 rg 0.05 Tc 8.6024 0 0 7.9001 470.94 198.01 Tm (Ex)Tj 0.271 0.271 0.259 rg 0.0321 Tc 7.9001 0 0 7.9001 480.41 198.01 Tm (er)Tj 0.384 0.384 0.372 rg 0 Tc 0.852 0 Td (c)Tj 0.271 0.271 0.259 rg 0.0008 Tc 0.42 0 Td (ise )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 7.1036 0 0 7.9001 501.66 198.01 Tm (Plz)Tj 0.384 0.384 0.372 rg 0 Tc 7.9001 0 0 7.9001 510.43 198.01 Tm (y)Tj 0.271 0.271 0.259 rg 0.0072 Tc 0.527 0 Td (si)Tj 0.384 0.384 0.372 rg 0 Tc 0.657 0 Td (o)Tj 0.271 0.271 0.259 rg -0.035 Tc 7.1985 0 0 7.9001 523.76 198.01 Tm (/, )Tj EMC ET BT /T1_0 1 Tf 7.8965 0 0 8 301.17 188.89 Tm (1978)Tj 0.384 0.384 0.372 rg 0 Tc 8 0 0 8 316.68 188.89 Tm (, )Tj 0.271 0.271 0.259 rg -0.0247 Tc 0.551 0 Td (45)Tj 0.384 0.384 0.372 rg 0 Tc 1.009 0 Td (, )Tj ET BT /Suspect <>BDC 0.271 0.271 0.259 rg /T1_0 1 Tf 0.0176 Tc 8 0 0 8 333.936 188.89 Tm (846)Tj 0.384 0.384 0.372 rg 0 Tc 1.506 0 Td (-)Tj 0.271 0.271 0.259 rg -0.0116 Tc 0.594 0 Td (851. )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8 0 0 8 300.424 179.762 Tm (2)Tj 0.384 0.384 0.372 rg 0.526 0 Td (. )Tj ET BT /Suspect <>BDC 0.188 0.192 0.18 rg /T1_0 1 Tf 0.0378 Tc 8 0 0 8 314.36 179.762 Tm (Pack )Tj EMC ET BT 0.271 0.271 0.259 rg /T1_0 1 Tf 0.05 Tc 8.2971 0 0 8 333.59 179.76 Tm (AI)Tj 0.384 0.384 0.372 rg 0 Tc 8 0 0 8 342.6 179.76 Tm (, )Tj ET BT /Suspect <>BDC 0.271 0.271 0.259 rg /T1_0 1 Tf 8 0 0 8 347 179.76 Tm (H)Tj 0.384 0.384 0.372 rg 0.775 0 Td (e)Tj 0.271 0.271 0.259 rg 0.0437 Tc 0.489 0 Td (rtz )Tj EMC ET BT /T1_0 1 Tf 0.0096 Tc 8 0 0 8 368.608 179.76 Tm (BC)Tj 0.384 0.384 0.372 rg 0 Tc 1.369 0 Td (, )Tj 0.271 0.271 0.259 rg -0.0036 Tc 0.61 0 Td (Ledlie )Tj 0.05 Tc 8.2061 0 0 8 406.99 179.76 Tm (JF, )Tj 0.0392 Tc 8 0 0 8 420.45 179.76 Tm (Fishman )Tj 0.05 Tc 8.3498 0 0 8 452.15 179.76 Tm (AP)Tj 0.384 0.384 0.372 rg 0 Tc 8 0 0 8 463.52 179.76 Tm (.)Tj 0.529 0.533 0.522 rg 0.489 0 Td (-)Tj 0.271 0.271 0.259 rg -0.0279 Tc 0.966 0 Td (Reflex )Tj 0.384 0.384 0.372 rg 0 Tc 2.815 0 Td (e)Tj 0.271 0.271 0.259 rg -0.027 Tc 0.479 0 Td (ffecl)Tj 0.384 0.384 0.372 rg 0 Tc 1.737 0 Td [(s )-25(o)]TJ 0.271 0.271 0.259 rg 1.262 0 Td (f )Tj 0.05 Tc 8.0089 0 0 8 300.4 170.65 Tm (aero)Tj 0.384 0.384 0.372 rg 0 Tc 8 0 0 8 315.25 170.65 Tm (s)Tj 0.271 0.271 0.259 rg -0.0068 Tc 0.424 0 Td (oli)Tj 0.384 0.384 0.372 rg 0 Tc 1.025 0 Td (z)Tj 0.271 0.271 0.259 rg 0.0368 Tc 0.415 0 Td (ed )Tj 0.0069 Tc 1.269 0 Td (hi)Tj 0.384 0.384 0.372 rg 0 Tc 0.827 0 Td (s)Tj 0.271 0.271 0.259 rg 0.0331 Tc 0.431 0 Td (tamine )Tj 0.0404 Tc 3.173 0 Td (on )Tj 0.0322 Tc 1.391 0 Td (phrenic )Tj 0.0161 Tc 3.418 0 Td (nerve )Tj 0.0251 Tc 2.571 0 Td (ac)Tj 0.384 0.384 0.372 rg 0 Tc 0.961 0 Td (l)Tj 0.188 0.192 0.18 rg 0.0113 Tc 0.3 0 Td (ivity)Tj 0.384 0.384 0.372 rg 0 Tc 1.909 0 Td (. )Tj 0.271 0.271 0.259 rg /T1_3 1 Tf 7.7 0 0 7.7 463.61 170.65 Tm (J )Tj /T1_2 1 Tf -0.0031 Tc 7.9001 0 0 7.9001 470.25 170.65 Tm (C/in )Tj 0.0113 Tc 1.973 0 Td (Invest, )Tj /T1_0 1 Tf -0.0229 Tc 8 0 0 8 510.44 170.65 Tm (1982)Tj 0.384 0.384 0.372 rg 0 Tc 1.94 0 Td (, )Tj ET BT /Suspect <>BDC 0.271 0.271 0.259 rg /T1_0 1 Tf 0.0173 Tc 8 0 0 8 299.92 162.01 Tm (70, )Tj EMC ET BT /T1_0 1 Tf 0.0076 Tc 8 0 0 8 312.928 162.01 Tm (424)Tj 0.384 0.384 0.372 rg 0 Tc 1.552 0 Td (-)Tj 0.271 0.271 0.259 rg 0.0076 Tc 0.487 0 Td (432)Tj 0.384 0.384 0.372 rg 0 Tc 1.604 0 Td (. )Tj 0.271 0.271 0.259 rg -0.035 Tc 7.7865 0 0 8 300.39 152.89 Tm (3. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0289 Tc 8 0 0 8 314.26 152.89 Tm (Savoy )Tj EMC /Suspect <>BDC 0.0291 Tc 2.893 0 Td (J, )Tj EMC ET BT /T1_0 1 Tf 0.0287 Tc 8 0 0 8 346.052 152.89 Tm (Fleelham )Tj 0.0371 Tc 4.259 0 Td (JA)Tj 0.384 0.384 0.372 rg 0 Tc 1.25 0 Td (, )Tj 0.271 0.271 0.259 rg 0.05 Tc 8.2061 0 0 8 394.07 152.89 Tm (Arnup )Tj 8.4241 0 0 8 419.48 152.89 Tm (ME)Tj 0.384 0.384 0.372 rg 0 Tc 8 0 0 8 432.84 152.89 Tm (, )Tj 0.271 0.271 0.259 rg 0.0353 Tc 0.494 0 Td (Anlhonisen )Tj 0.05 Tc 8.009 0 0 8 479.08 152.89 Tm (NR.)Tj 0.529 0.533 0.522 rg 0 Tc 8 0 0 8 495.75 152.89 Tm (-)Tj 0.271 0.271 0.259 rg 0.0138 Tc 0.91 0 Td (Airway )Tj 0.0186 Tc -25.329 -1.141 Td (aneslhesia )Tj 0.05 Tc 8.1466 0 0 8 340.24 143.76 Tm (and )Tj 0.0352 Tc 8 0 0 8 358.55 143.76 Tm (respiratory )Tj 0.0233 Tc 5.4 0 Td (response )Tj 0.05 Tc 8.1489 0 0 8 436.3 143.76 Tm (to )Tj 0.0192 Tc 8 0 0 8 448.31 143.76 Tm (methylcholine )Tj 0.0155 Tc 6.652 0 Td (induced )Tj 0.0332 Tc -25.13 -1.079 Td (broncboconstriclion)Tj 0.384 0.384 0.372 rg 0 Tc 8.619 0 Td (. )Tj 0.271 0.271 0.259 rg /T1_2 1 Tf 0.0436 Tc 7.9001 0 0 7.9001 374.94 135.13 Tm (Re)Tj 0.384 0.384 0.372 rg 0 Tc 1.029 0 Td (s)Tj 0.271 0.271 0.259 rg 0.0424 Tc 0.395 0 Td (pir )Tj 0.0122 Tc 1.614 0 Td (Physiol, )Tj /T1_0 1 Tf -0.035 Tc 7.3701 0 0 8 429.35 135.13 Tm (1981)Tj 0.384 0.384 0.372 rg 0 Tc 8 0 0 8 444.36 135.13 Tm (, )Tj 0.271 0.271 0.259 rg -0.0247 Tc 0.551 0 Td (43)Tj 0.384 0.384 0.372 rg 0 Tc 1.069 0 Td [(, )-101(5)]TJ 0.271 0.271 0.259 rg 1.024 0 Td (9)Tj 0.529 0.533 0.522 rg 0.54 0 Td (-)Tj 0.271 0.271 0.259 rg -0.035 Tc 7.8934 0 0 8 474.62 135.13 Tm (68. )Tj -0.0147 Tc 8 0 0 8 299.97 126 Tm (4. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0229 Tc 8 0 0 8 314.378 126 Tm (Vidruk )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.052 0 0 8 340.76 126 Tm (EH, )Tj 8.3339 0 0 8 356.6 126 Tm (Hahn )Tj 8.4036 0 0 8 378.68 126 Tm (HL)Tj 0.384 0.384 0.372 rg 0 Tc 8 0 0 8 390.6 126 Tm (, )Tj 0.271 0.271 0.259 rg 0.0337 Tc (Nadel )Tj 0.118 0.118 0.106 rg 0 Tc 3.31 0 Td (J)Tj 0.271 0.271 0.259 rg 0.424 0 Td (A)Tj 0.384 0.384 0.372 rg 0.826 0 Td (, )Tj ET BT /Suspect <>BDC 0.271 0.271 0.259 rg /T1_0 1 Tf 0.0349 Tc 8 0 0 8 430.896 126 Tm (Sampson )Tj EMC /Suspect <>BDC 0.05 Tc 8.5337 0 0 8 464 126 Tm (SR)Tj 0.384 0.384 0.372 rg 14.6343 0 0 8 474.41 126 Tm (.-)Tj EMC ET BT 0.271 0.271 0.259 rg /T1_0 1 Tf 0.0193 Tc 8 0 0 8 485.73 126 Tm (Mechani)Tj 0.384 0.384 0.372 rg 0 Tc 3.65 0 Td (s)Tj 0.271 0.271 0.259 rg 0.433 0 Td (m)Tj 0.384 0.384 0.372 rg 0.767 0 Td (s )Tj 0.271 0.271 0.259 rg 0.0296 Tc -28.005 -1.08 Td (by )Tj 0.0027 Tc 1.437 0 Td (whi)Tj 0.384 0.384 0.372 rg 0 Tc 1.491 0 Td (c)Tj 0.271 0.271 0.259 rg 0.489 0 Td (h )Tj 0.0326 Tc 0.96 0 Td (hislamine )Tj 0.0217 Tc 4.548 0 Td (stimul)Tj 0.384 0.384 0.372 rg 0 Tc 2.644 0 Td (a)Tj 0.188 0.192 0.18 rg -0.0133 Tc 0.547 0 Td (tes )Tj 0.271 0.271 0.259 rg 0.0418 Tc 1.561 0 Td (rapid)Tj 0.384 0.384 0.372 rg 0 Tc 2.273 0 Td (l)Tj 0.271 0.271 0.259 rg 0.247 0 Td (y )Tj 0.0416 Tc 0.951 0 Td (adapling )Tj 0.0224 Tc 4.149 0 Td (receplors )Tj -0.035 Tc 7.9356 0 0 8 505.38 117.36 Tm (in )Tj 0.05 Tc 8.1459 0 0 8 514.96 117.36 Tm (dog )Tj 0.0118 Tc 8 0 0 8 300.41 108.25 Tm (lungs. )Tj /T1_3 1 Tf 0 Tc 7.8001 0 0 7.8001 322.49 108.25 Tm (J )Tj /T1_2 1 Tf 0.05 Tc 8.0306 0 0 7.9001 329.4 108.25 Tm (Appl )Tj 0.0386 Tc 7.9001 0 0 7.9001 348.06 108.25 Tm (Phy)Tj 0.384 0.384 0.372 rg 0 Tc 1.637 0 Td (s)Tj 0.271 0.271 0.259 rg 0.0283 Tc 0.409 0 Td (iol)Tj 0.384 0.384 0.372 rg 0 Tc 1.089 0 Td (: )Tj 0.271 0.271 0.259 rg 0.0436 Tc 0.694 0 Td (Re)Tj 0.384 0.384 0.372 rg 0 Tc 1.09 0 Td (s)Tj 0.271 0.271 0.259 rg 0.0244 Tc 0.334 0 Td (pirat )Tj -0.002 Tc 2.465 0 Td (Environ )Tj 0.05 Tc 7.9689 0 0 7.9001 437.34 108.25 Tm (Exer)Tj 0.384 0.384 0.372 rg 0 Tc 7.9001 0 0 7.9001 453.06 108.25 Tm (c)Tj 0.271 0.271 0.259 rg 0.0008 Tc 0.481 0 Td (ise )Tj 0.0053 Tc 1.478 0 Td (Physiol)Tj 0.384 0.384 0.372 rg 0 Tc 3.034 0 Td (, )Tj 0.188 0.192 0.18 rg /T1_0 1 Tf -0.035 Tc 7.8965 0 0 8 497.97 108.25 Tm (1977)Tj 0.384 0.384 0.372 rg 0 Tc 8 0 0 8 513 108.25 Tm (, )Tj 0.271 0.271 0.259 rg -0.0247 Tc 0.551 0 Td (43)Tj 0.384 0.384 0.372 rg 0 Tc 1.009 0 Td (, )Tj ET BT /Suspect <>BDC 0.271 0.271 0.259 rg /T1_0 1 Tf -0.0115 Tc 8 0 0 8 300.392 99.122 Tm (397)Tj 0.529 0.533 0.522 rg 0 Tc 1.5 0 Td (-)Tj 0.271 0.271 0.259 rg 0.0076 Tc 0.547 0 Td (402)Tj 0.004 0.004 0 rg 0 Tc 1.544 0 Td (. )Tj EMC ET endstream endobj 80 0 obj 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9.7 62.34 778.8 Tm (216 )Tj 0.05 Tc 9.165 0 0 7.5001 262.51 779.29 Tm (J. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.2451 0 0 7.7 273.93 779.29 Tm (SAVOY )Tj EMC ET BT /T1_0 1 Tf 8.4 0 0 8.2 308.11 779.29 Tm (ET )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.591 0 0 7.7 323.02 779.29 Tm (AL. )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 7.5657 0 0 8.2 62.32 755.29 Tm (5. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0015 Tc 8.2 0 0 8.2 76.17 755.29 Tm (Savoy )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.46 0 0 8.2 98.35 755.29 Tm (J, )Tj 0.0004 Tc 8.2 0 0 8.2 106.07 755.29 Tm (Allgoewer )Tj -0.0276 Tc 4.444 0 Td (E, )Tj 0.0361 Tc 1.05 0 Td (CourteheuseC, )Tj 0.0487 Tc 6.56 0 Td (Junod )Tj 0.05 Tc 9.8146 0 0 8.2 227.98 755.29 Tm (AF.-)Tj 0.0141 Tc 8.2 0 0 8.2 249.58 755.29 Tm (Ventilatory )Tj 0.0106 Tc -22.887 -1.112 Td (response )Tj -0.0137 Tc 3.862 0 Td (to )Tj 0.0188 Tc 1.057 0 Td (bronchospasm )Tj 0.0121 Tc 6.195 0 Td (induced )Tj -0.035 Tc 8.0386 0 0 8.2 181.93 746.17 Tm (by )Tj 0.0071 Tc 8.2 0 0 8.2 191.5 746.17 Tm (methylcholine )Tj 0.045 Tc 6.022 0 Td (and )Tj 0.02 Tc 1.765 0 Td (histamine )Tj 0.0001 Tc -23.598 -1.054 Td (in )Tj 0.2 0.2 0.188 rg -0.009 Tc 1.118 0 Td (men)Tj 0.341 0.345 0.333 rg 0 Tc 1.796 0 Td (. )Tj 0.259 0.263 0.247 rg /T1_1 1 Tf 0.0058 Tc 0.555 0 Td (Respir )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0053 Tc 8.2 0 0 8.2 114.297 737.5272 Tm (Physiol, )Tj EMC ET BT /T1_0 1 Tf -0.0178 Tc 8.2 0 0 8.2 144.1942 737.5272 Tm (1984, )Tj -0.0292 Tc 2.479 0 Td (56)Tj 0.4 0.404 0.392 rg 0 Tc 0.934 0 Td (, )Tj 0.259 0.263 0.247 rg -0.035 Tc 7.7728 0 0 8.2 177.81 737.53 Tm (195)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 189.03 737.53 Tm (-)Tj 0.259 0.263 0.247 rg -0.0307 Tc 0.59 0 Td (203. )Tj -0.023 Tc -16.104 -1.112 Td (6. )Tj 0.0286 Tc 1.7 0 Td (Gilbert )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0229 Tc 8.2 0 0 8.2 102.6758 728.4116 Tm (R, )Tj EMC ET BT /T1_0 1 Tf 0.0041 Tc 8.2 0 0 8.2 112.7864 728.4116 Tm (Auchincloss )Tj 0.05 Tc 8.2597 0 0 8.2 155.47 728.41 Tm (JH, )Tj 0.2 0.2 0.188 rg 0.0048 Tc 8.2 0 0 8.2 170.36 728.41 Tm (Brodsky )Tj 0.259 0.263 0.247 rg 0.0389 Tc 8.6 0 0 8.6 200.11 728.41 Tm (J, )Tj 0.2 0.2 0.188 rg 0.0117 Tc 8.2 0 0 8.2 208.28 728.41 Tm (Boden )Tj 0.259 0.263 0.247 rg 0.05 Tc 10.3747 0 0 8.2 231.8 728.41 Tm (W.-)Tj 0.0155 Tc 8.2 0 0 8.2 250.48 728.41 Tm (Changes )Tj 0.0001 Tc 3.806 0 Td (in )Tj 0.0107 Tc -26.804 -1.055 Td (tidal )Tj 0.0061 Tc 2.166 0 Td (volume, )Tj -0.0042 Tc 3.621 0 Td (frequency )Tj 0.045 Tc 4.333 0 Td (and )Tj 0.0125 Tc 1.88 0 Td (ventilation )Tj 0.0121 Tc 4.735 0 Td (induced )Tj 0.0047 Tc 3.58 0 Td (by )Tj 0.0114 Tc 1.343 0 Td (their )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0119 Tc 8.2 0 0 8.2 257.7288 719.759 Tm (measure)Tj 0.09 0.094 0.078 rg 0 Tc 3.387 0 Td (\255)Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0101 Tc 8.2 0 0 8.2 61.4126 710.6488 Tm (ment. )Tj /T1_2 1 Tf 0 Tc 7.7 0 0 7.7 83.45 710.65 Tm (J )Tj /T1_1 1 Tf 0.036 Tc 8.2 0 0 8.2 90.37 710.65 Tm (Appl )Tj -0.0136 Tc 2.274 0 Td (Physiol, )Tj /T1_0 1 Tf -0.0325 Tc 3.646 0 Td (1972, )Tj -0.0212 Tc 2.423 0 Td (33, )Tj -0.035 Tc 8.1639 0 0 8.2 171.31 710.65 Tm (252)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 183.27 710.65 Tm (-)Tj 0.259 0.263 0.247 rg -0.035 Tc 8.1639 0 0 8.2 188.11 710.65 Tm (254)Tj 0.09 0.094 0.078 rg 0 Tc 8.2 0 0 8.2 199.99 710.65 Tm (. )Tj 0.259 0.263 0.247 rg -0.023 Tc -16.907 -1.055 Td (7. )Tj 0.2 0.2 0.188 rg 0.015 Tc 1.762 0 Td (Boucher )Tj 0.259 0.263 0.247 rg 0.0297 Tc 3.746 0 Td (RC, )Tj 0.2 0.2 0.188 rg 0.0306 Tc 1.93 0 Td (Johnson )Tj 0.259 0.263 0.247 rg 0.05 Tc 8.46 0 0 8.2 153.07 702 Tm (J, )Tj 0.2 0.2 0.188 rg 0.0347 Tc 8.2 0 0 8.2 161.22 702 Tm (Inoue )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf -0.0105 Tc 8.2 0 0 8.2 183.2124 702 Tm (S, )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0298 Tc 8.2 0 0 8.2 191.9618 702 Tm (Hulbert )Tj 0 Tc 3.513 0 Td (W)Tj 0.341 0.345 0.333 rg 0.983 0 Td (, )Tj 0.2 0.2 0.188 rg 0.0435 Tc 0.538 0 Td (Hogg )Tj -0.0045 Tc 2.574 0 Td (JC. )Tj 0.341 0.345 0.333 rg 0 Tc 1.693 0 Td (-)Tj 0.2 0.2 0.188 rg 0.05 Tc 8.2125 0 0 8.2 274.49 702 Tm (The )Tj 0.259 0.263 0.247 rg -0.0173 Tc 8.2 0 0 8.2 61.35 692.89 Tm (effect )Tj 0.05 Tc 8.9033 0 0 8.2 81.52 692.89 Tm (of )Tj 0.012 Tc 8.2 0 0 8.2 90.64 692.89 Tm (cigarette )Tj 0.0126 Tc 3.8 0 Td (smoke )Tj 0.0155 Tc 2.932 0 Td (on )Tj 0.2 0.2 0.188 rg 0.0351 Tc 1.295 0 Td (the )Tj 0.259 0.263 0.247 rg 0.0103 Tc 1.584 0 Td (permeability )Tj 0.05 Tc 8.9033 0 0 8.2 213.52 692.89 Tm (of )Tj 0.0206 Tc 8.2 0 0 8.2 222.65 692.89 Tm (guinea )Tj 0.0099 Tc 2.995 0 Td (pig )Tj 0.007 Tc 1.511 0 Td (airways. )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0416 Tc 8.2 0 0 8.2 61.52 684.239 Tm (Lab )Tj EMC ET BT /T1_1 1 Tf -0.0054 Tc 8.2 0 0 8.2 77.3624 684.239 Tm (Invest, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.0056 0 0 8.2 102.92 684.24 Tm (1980, )Tj EMC ET BT /T1_0 1 Tf -0.0027 Tc 8.2 0 0 8.2 122.37 684.24 Tm (43, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0355 Tc 8.2 0 0 8.2 135.2686 684.24 Tm (94-100)Tj 0.09 0.094 0.078 rg 0 Tc 3.034 0 Td (. )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf -0.0125 Tc 8.2 0 0 8.2 61.2964 675.1216 Tm (8. )Tj 0.2 0.2 0.188 rg 0.0298 Tc 1.768 0 Td (Hulbert )Tj 0.259 0.263 0.247 rg 0.0104 Tc 3.689 0 Td (WC, )Tj 0.0223 Tc 2.4 0 Td (Walker )Tj 0.2 0.2 0.188 rg 0.05 Tc 8.4422 0 0 8.2 155 675.12 Tm (DC)Tj 0.341 0.345 0.333 rg 0 Tc 8.2 0 0 8.2 166.91 675.12 Tm (, )Tj 0.2 0.2 0.188 rg 0.0204 Tc 0.712 0 Td (Jackson )Tj 0.259 0.263 0.247 rg 0.0289 Tc 3.81 0 Td (A, )Tj 0.024 Tc 1.518 0 Td (Hogg )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf -0.0045 Tc 8.2 0 0 8.2 238.988 675.12 Tm (JC. )Tj EMC ET BT 0.4 0.404 0.392 rg /T1_0 1 Tf 0 Tc 8.2 0 0 8.2 254.3056 675.12 Tm (-)Tj 0.259 0.263 0.247 rg -0.0012 Tc 1.063 0 Td (Airway )Tj 0.2 0.2 0.188 rg 0.0103 Tc -24.583 -1.054 Td (permeability )Tj 0.341 0.345 0.333 rg -0.0137 Tc 5.616 0 Td (to )Tj 0.2 0.2 0.188 rg 0.0197 Tc 1.23 0 Td (horseradish )Tj 0.259 0.263 0.247 rg 0.0079 Tc 5.212 0 Td (peroxidase )Tj 0.0001 Tc 4.79 0 Td (in )Tj 0.0206 Tc 1.171 0 Td (guinea )Tj 0.2 0.2 0.188 rg -0.0298 Tc 3.171 0 Td (pigs: )Tj 0.0351 Tc 2.279 0 Td (the )Tj 0.259 0.263 0.247 rg 0.026 Tc 1.699 0 Td (repair )Tj 0.0189 Tc -25.168 -1.112 Td (phase )Tj 0.0284 Tc 2.74 0 Td (after )Tj 0.0058 Tc 2.343 0 Td (injury )Tj -0.035 Tc 8.0386 0 0 8.2 126.73 657.36 Tm (by )Tj 0.0193 Tc 8.2 0 0 8.2 137.68 657.36 Tm (cigarette )Tj 0.0069 Tc 3.917 0 Td (smoke. )Tj /T1_1 1 Tf 0.05 Tc 8.7132 0 0 8.2 197.41 657.36 Tm (Am )Tj 0.0144 Tc 8.2 0 0 8.2 212.7 657.36 Tm (Rev )Tj -0.0059 Tc 1.932 0 Td (Respir )Tj 0.0066 Tc 2.988 0 Td (Dis)Tj 0.4 0.404 0.392 rg 0 Tc 1.399 0 Td (, )Tj 0.259 0.263 0.247 rg /T1_0 1 Tf -0.0325 Tc 0.723 0 Td (1981, )Tj -0.0327 Tc -25.405 -1.052 Td (123, )Tj 0.0119 Tc 1.955 0 Td (320-326. )Tj -0.035 Tc 7.6511 0 0 8.2 61.35 639.61 Tm (9. )Tj 0.0198 Tc 8.2 0 0 8.2 75.32 639.61 Tm (Laitinen )Tj -0.0296 Tc 3.926 0 Td (A. )Tj 0.4 0.404 0.392 rg 0 Tc 1.454 0 Td (-)Tj 0.259 0.263 0.247 rg 0.0234 Tc 1.122 0 Td (Ultrastructural )Tj 0.0211 Tc 6.665 0 Td (organisation )Tj 0.05 Tc 8.9033 0 0 8.2 229.84 639.61 Tm (of )Tj 0.0149 Tc 8.2 0 0 8.2 240.41 639.61 Tm (intraepithelial )Tj -0.0058 Tc -21.827 -1.113 Td (nerves )Tj 0.0001 Tc 2.92 0 Td (in )Tj 0.0058 Tc 1.177 0 Td (the )Tj 0.038 Tc 1.523 0 Td (human )Tj 0.0089 Tc 3.211 0 Td (airway )Tj 0.0056 Tc 3.168 0 Td (tract. )Tj /T1_1 1 Tf 0.0125 Tc 2.499 0 Td (Thorax, )Tj /T1_0 1 Tf -0.0325 Tc 3.616 0 Td (1985, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0027 Tc 8.2 0 0 8.2 229.8894 630.4834 Tm (40, )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_0 1 Tf -0.0106 Tc 8.2 0 0 8.2 242.8454 630.4834 Tm (488)Tj 0.341 0.345 0.333 rg 0 Tc 1.456 0 Td (-)Tj 0.2 0.2 0.188 rg -0.0319 Tc 0.593 0 Td (492. )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf -0.035 Tc 7.3607 0 0 8.2 62.15 621.85 Tm (10. )Tj EMC ET BT /T1_0 1 Tf 0.0281 Tc 8.2 0 0 8.2 79.15 621.85 Tm (Juniper )Tj 0.0301 Tc 3.395 0 Td (EF, )Tj 0.2 0.2 0.188 rg 0.0307 Tc 1.817 0 Td (Frith )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0339 Tc 8.2 0 0 8.2 141.0764 621.85 Tm (PA, )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0419 Tc 8.2 0 0 8.2 156.435 621.85 Tm (Dunnett )Tj 0.259 0.263 0.247 rg 0.0422 Tc 3.741 0 Td (C, )Tj 0.0155 Tc 1.229 0 Td (Cockcroft )Tj 0.0459 Tc 4.395 0 Td (DW, )Tj 0.0229 Tc 2.341 0 Td (Hargreave )Tj 0.003 Tc -23.296 -1.112 Td (FE. )Tj 0.341 0.345 0.333 rg 0 Tc 1.983 0 Td (-)Tj 0.2 0.2 0.188 rg 0.0122 Tc 1.118 0 Td (Reproducibility )Tj 0.259 0.263 0.247 rg 0.045 Tc 6.902 0 Td (and )Tj 0.0176 Tc 2.049 0 Td (comparison )Tj 0.05 Tc 8.9033 0 0 8.2 204.4 612.73 Tm (of )Tj 0.0045 Tc 8.2 0 0 8.2 215.51 612.73 Tm (responses )Tj 0.0449 Tc 4.448 0 Td (to )Tj 0.02 Tc 1.282 0 Td (inhaled )Tj 0.0127 Tc -24.52 -1.054 Td (histamine )Tj 0.045 Tc 4.265 0 Td (and )Tj 0.0009 Tc 1.88 0 Td (methylcholine. )Tj /T1_1 1 Tf 0.0125 Tc 6.421 0 Td (Thorax, )Tj /T1_0 1 Tf -0.0325 Tc 3.674 0 Td (1978, )Tj -0.035 Tc 7.9784 0 0 8.2 214.95 604.09 Tm (33, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0185 Tc 8.2 0 0 8.2 226.95 604.09 Tm (705-710. )Tj EMC /Suspect <>BDC 0.2 0.2 0.188 rg 0.05 Tc 8.6289 0 0 8.2 61.86 594.97 Tm (II. )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0214 Tc 8.2 0 0 8.2 79.16 594.97 Tm (Morel )Tj 0.05 Tc 8.3651 0 0 8.2 102.68 594.97 Tm (DR, )Tj 0.0286 Tc 8.2 0 0 8.2 119.97 594.97 Tm (Forster )Tj 0.0289 Tc 3.339 0 Td (A, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0229 Tc 8.2 0 0 8.2 158.2476 594.97 Tm (Suter )Tj EMC /Suspect <>BDC 0.2 0.2 0.188 rg 0.0338 Tc 2.472 0 Td (PM)Tj 0.09 0.094 0.078 rg 0 Tc 1.565 0 Td (. )Tj EMC ET BT 0.4 0.404 0.392 rg /T1_0 1 Tf 8.2 0 0 8.2 195.7544 594.97 Tm (-)Tj 0.259 0.263 0.247 rg 0.0463 Tc 0.952 0 Td (Non )Tj 0.0034 Tc 2.094 0 Td (invasive )Tj 0.0186 Tc 3.635 0 Td (ventilatory )Tj 0.0274 Tc -23.122 -1.112 Td (monitoring )Tj 0.2 0.2 0.188 rg -0.0052 Tc 4.977 0 Td (with )Tj 0.259 0.263 0.247 rg -0.0091 Tc 2.168 0 Td (bellows )Tj 0.0246 Tc 3.337 0 Td (pneumographs )Tj 0.0001 Tc 6.488 0 Td (in )Tj 0.0101 Tc 1.106 0 Td (supine )Tj 0.0014 Tc 2.985 0 Td (subjects. )Tj 0.2 0.2 0.188 rg /T1_1 1 Tf 0 Tc 3.83 0 Td (J )Tj 0.259 0.263 0.247 rg 0.05 Tc 8.2668 0 0 8.2 271.33 585.85 Tm (Appl )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0087 Tc 8.2 0 0 8.2 61.02 577.21 Tm (Physiol: )Tj EMC ET BT /T1_1 1 Tf -0.0065 Tc 8.2 0 0 8.2 91.2616 577.21 Tm (Respirat )Tj -0.0118 Tc 3.688 0 Td (Environ )Tj 0.0005 Tc 3.512 0 Td (Exercise )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0031 Tc 8.2 0 0 8.2 181.0188 577.21 Tm (Physio/, )Tj EMC ET BT /T1_0 1 Tf -0.0325 Tc 8.2 0 0 8.2 211.3998 577.21 Tm (1983, )Tj /T1_1 1 Tf -0.0311 Tc 2.424 0 Td (55, )Tj /T1_0 1 Tf -0.0305 Tc 1.518 0 Td (598)Tj 0.09 0.094 0.078 rg 0 Tc 1.466 0 Td (-)Tj 0.259 0.263 0.247 rg -0.0288 Tc 0.584 0 Td (606. )Tj -0.035 Tc 8.0574 0 0 8.2 61.16 568.09 Tm (12)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 68.95 568.09 Tm (. )Tj 0.2 0.2 0.188 rg 0.035 Tc 1.19 0 Td (Abraham )Tj -0.0107 Tc 4.329 0 Td (WM)Tj 0.341 0.345 0.333 rg 0 Tc 1.92 0 Td (, )Tj 0.259 0.263 0.247 rg 0.0231 Tc 0.539 0 Td (Watson )Tj 0.2 0.2 0.188 rg 0 Tc 3.57 0 Td (H)Tj 0.341 0.345 0.333 rg 0.809 0 Td (, )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0098 Tc 8.2 0 0 8.2 174.5742 568.09 Tm (Schneider )Tj EMC ET BT /T1_0 1 Tf 0.0289 Tc 8.2 0 0 8.2 210.7116 568.09 Tm (A, )Tj 0.2 0.2 0.188 rg 0.0173 Tc 1.343 0 Td (King )Tj 0.0423 Tc 2.4 0 Td (M, )Tj 0.0203 Tc 1.524 0 Td (Yerger )Tj -0.0282 Tc 3.217 0 Td (L, )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0158 Tc 8.2 0 0 8.2 60.8074 559.439 Tm (Sackner )Tj EMC ET BT /T1_0 1 Tf -0.0179 Tc 8.2 0 0 8.2 90.1962 559.439 Tm (MA. )Tj 0.341 0.345 0.333 rg 0 Tc 2.16 0 Td (-)Tj 0.259 0.263 0.247 rg 0.0108 Tc 0.777 0 Td (Non-invasive )Tj 0.0127 Tc 5.729 0 Td (ventilatory )Tj 0.2 0.2 0.188 rg 0.0209 Tc 4.741 0 Td (monitoring )Tj 0.259 0.263 0.247 rg 0.0047 Tc 4.862 0 Td (by )Tj 0.018 Tc 1.227 0 Td (respiratory )Tj 0.0057 Tc -23.071 -1.111 Td (inductive )Tj 0.0151 Tc 4.283 0 Td (plethysmography )Tj 0.0001 Tc 7.659 0 Td (in )Tj 0.0148 Tc 1.287 0 Td (conscious )Tj -0.0082 Tc 4.561 0 Td (sheep. )Tj /T1_2 1 Tf 0 Tc 8 0 0 8 231.77 550.33 Tm (J )Tj 0.2 0.2 0.188 rg /T1_1 1 Tf 0.036 Tc 8.2 0 0 8.2 240.13 550.33 Tm (Appl )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0063 Tc 8.2 0 0 8.2 260.22 550.33 Tm (Physiol)Tj 0.4 0.404 0.392 rg 0 Tc 3.02 0 Td (: )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_1 1 Tf -0.0065 Tc 8.2 0 0 8.2 61.0256 541.679 Tm (Respirat )Tj -0.0118 Tc 3.688 0 Td (Environ )Tj 0.0005 Tc 3.512 0 Td (Exercise )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0053 Tc 8.2 0 0 8.2 151.2666 541.679 Tm (Physiol, )Tj EMC ET BT /T1_0 1 Tf -0.0178 Tc 8.2 0 0 8.2 180.6882 541.679 Tm (1981, )Tj -0.0225 Tc 2.479 0 Td (51, )Tj 0.2 0.2 0.188 rg -0.035 Tc 7.8965 0 0 8.2 214.77 541.68 Tm (1657)Tj 0.341 0.345 0.333 rg 0.0267 Tc 8.2 0 0 8.2 229.83 541.68 Tm (-1661. )Tj 0.259 0.263 0.247 rg -0.035 Tc 7.7937 0 0 8.2 61.17 532.56 Tm (13. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0133 Tc 8.2 0 0 8.2 78.64 532.56 Tm (Orehek )Tj EMC ET BT /T1_0 1 Tf 0.0389 Tc 8.6 0 0 8.6 107.95 532.56 Tm (J, )Tj 0.0232 Tc 8.2 0 0 8.2 118.96 532.56 Tm (Charpin )Tj 0.2 0.2 0.188 rg 0.0397 Tc 4.044 0 Td (D, )Tj 0.259 0.263 0.247 rg 0.0116 Tc 1.641 0 Td (Velardocchio )Tj 0.05 Tc 8.2971 0 0 8.2 215.47 532.56 Tm (JM, )Tj 0.0447 Tc 8.2 0 0 8.2 233.68 532.56 Tm (Grimaud )Tj -0.0164 Tc 4.39 0 Td (C. )Tj 0.4 0.404 0.392 rg 0 Tc 1.579 0 Td (-)Tj 0.259 0.263 0.247 rg 0.0308 Tc -27.096 -1.112 Td (Bronchomotor )Tj -0.0173 Tc 6.433 0 Td (effect )Tj 0.05 Tc 8.9033 0 0 8.2 133.36 523.44 Tm (of )Tj 0.0156 Tc 8.2 0 0 8.2 143.05 523.44 Tm (bronchoconstriction-induced )Tj -0.0013 Tc 12.223 0 Td (deep )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0179 Tc 8.2 0 0 8.2 261.048 523.44 Tm (inspira\255)Tj EMC ET BT /T1_0 1 Tf 0.0124 Tc 8.2 0 0 8.2 60.4596 514.7972 Tm (tions )Tj 0.05 Tc 8.2876 0 0 8.2 79.61 514.8 Tm (in )Tj 0.0112 Tc 8.2 0 0 8.2 88.72 514.8 Tm (asthmatics. )Tj /T1_1 1 Tf 0.05 Tc 8.7132 0 0 8.2 129.73 514.8 Tm (Am )Tj 0.0437 Tc 8.2 0 0 8.2 144.06 514.8 Tm (Rev )Tj 0.0058 Tc 1.873 0 Td (Respir )Tj -0.0204 Tc 2.988 0 Td (Dis, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.1597 0 0 8.2 200.36 514.8 Tm (1980)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 215.87 514.8 Tm (, )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf -0.035 Tc 7.9309 0 0 8.2 221.49 514.8 Tm (121, )Tj 0.0177 Tc 8.2 0 0 8.2 237.07 514.8 Tm (297-305. )Tj 0.2 0.2 0.188 rg -0.035 Tc 7.3607 0 0 8.2 61.19 505.69 Tm (14. )Tj 0.259 0.263 0.247 rg 0.0366 Tc 8.2 0 0 8.2 78.17 505.69 Tm (Tobin )Tj 0.0204 Tc 2.872 0 Td (MJ)Tj 0.4 0.404 0.392 rg 0 Tc 1.335 0 Td (, )Tj 0.259 0.263 0.247 rg 0.0378 Tc 0.533 0 Td (Chadha )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0027 Tc 8.2 0 0 8.2 146.3284 505.69 Tm (TS, )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0281 Tc 8.2 0 0 8.2 160.2684 505.69 Tm (Jenouri )Tj 0.0386 Tc 3.45 0 Td (GA, )Tj 0.2 0.2 0.188 rg -0.0079 Tc 2.112 0 Td (Birch )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf -0.0105 Tc 8.2 0 0 8.2 226.4096 505.69 Tm (S, )Tj EMC ET BT /T1_0 1 Tf 0.0232 Tc 8.2 0 0 8.2 235.118 505.69 Tm (Gazeroglu )Tj 0.2 0.2 0.188 rg 0.0354 Tc 4.629 0 Td (HB, )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0158 Tc 8.2 0 0 8.2 60.3268 496.5634 Tm (Sackner )Tj EMC ET BT /T1_0 1 Tf 0.0114 Tc 8.2 0 0 8.2 89.7156 496.5634 Tm (MA.)Tj 0.4 0.404 0.392 rg 0 Tc 2.16 0 Td (-)Tj 0.2 0.2 0.188 rg 0.0225 Tc 0.826 0 Td (Breathing )Tj 0.259 0.263 0.247 rg 0.0171 Tc 4.338 0 Td (pattern: )Tj /T1_3 1 Tf 0.05 Tc 7.8667 0 0 7.8001 179.3 496.56 Tm (I. )Tj /T1_0 1 Tf 0.0335 Tc 8.2 0 0 8.2 186.28 496.56 Tm (Normal )Tj 0.0014 Tc 3.493 0 Td (subjects. )Tj /T1_1 1 Tf 0.0003 Tc 3.8 0 Td (Chest, )Tj /T1_0 1 Tf -0.035 Tc 7.8965 0 0 8.2 269.97 496.56 Tm (1983)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 284.99 496.56 Tm (, )Tj 0.259 0.263 0.247 rg -0.0221 Tc -27.396 -1.052 Td (83, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0088 Tc 8.2 0 0 8.2 72.9134 487.9336 Tm (202)Tj 0.4 0.404 0.392 rg 0 Tc 1.459 0 Td (-)Tj 0.2 0.2 0.188 rg -0.0307 Tc 0.59 0 Td (205. )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf -0.035 Tc 7.3607 0 0 8.2 61.19 478.81 Tm (15. )Tj 0.0228 Tc 8.2 0 0 8.2 78.16 478.81 Tm (Cockcroft )Tj 0.0459 Tc 4.571 0 Td (DW, )Tj -0.0063 Tc 2.4 0 Td (Berscheid )Tj 0.2 0.2 0.188 rg -0.035 Tc 7.9315 0 0 8.2 171.33 478.81 Tm (BA)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 182.71 478.81 Tm (. )Tj 0.341 0.345 0.333 rg 0.654 0 Td (-)Tj 0.259 0.263 0.247 rg -0.0169 Tc 0.941 0 Td (Effect )Tj 0.05 Tc 8.9033 0 0 8.2 218.32 478.81 Tm (of )Tj 8.3611 0 0 8.2 228.49 478.81 Tm (pH )Tj 8.3916 0 0 8.2 242.32 478.81 Tm (on )Tj 0.0198 Tc 8.2 0 0 8.2 254.89 478.81 Tm (bronchial )Tj 0.0106 Tc -23.768 -1.055 Td (response )Tj 0.0449 Tc 3.921 0 Td (to )Tj 0.0103 Tc 1.165 0 Td (inhaled )Tj 0.0127 Tc 3.402 0 Td (histamine)Tj 0.4 0.404 0.392 rg 0 Tc 4.02 0 Td (. )Tj 0.259 0.263 0.247 rg /T1_1 1 Tf 0.0027 Tc 0.585 0 Td (Thorax, )Tj /T1_0 1 Tf -0.035 Tc 8.0056 0 0 8.2 197.48 470.16 Tm (1982, )Tj -0.0212 Tc 8.2 0 0 8.2 217.35 470.16 Tm (37, )Tj 0.2 0.2 0.188 rg -0.035 Tc 7.7728 0 0 8.2 230.61 470.16 Tm (133)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 241.83 470.16 Tm (-)Tj 0.2 0.2 0.188 rg -0.035 Tc 7.9309 0 0 8.2 247.41 470.16 Tm (136. )Tj 7.7937 0 0 8.2 60.69 461.05 Tm (16. )Tj 0.259 0.263 0.247 rg -0.0232 Tc 8.2 0 0 8.2 78.21 461.05 Tm (Weiss )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0105 Tc 8.2 0 0 8.2 102.5722 461.05 Tm (S, )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0397 Tc 8.2 0 0 8.2 114.1998 461.05 Tm (Robb )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.05 Tc 8.3326 0 0 8.2 137.68 461.05 Tm (GP, )Tj EMC ET BT /T1_0 1 Tf -0.0153 Tc 8.2 0 0 8.2 156.43 461.05 Tm (Ellis )Tj -0.0252 Tc 2.401 0 Td (LB. )Tj 0.341 0.345 0.333 rg 0 Tc 2.101 0 Td (-)Tj 0.259 0.263 0.247 rg 0.05 Tc 8.2125 0 0 8.2 202.49 461.05 Tm (The )Tj -0.0023 Tc 8.2 0 0 8.2 220.68 461.05 Tm (systemic )Tj -0.0109 Tc 4.043 0 Td (effects )Tj 0.2 0.2 0.188 rg 0.05 Tc 9.4598 0 0 8.2 279.75 461.05 Tm (of )Tj 0.0127 Tc 8.2 0 0 8.2 59.99 451.93 Tm (histamine )Tj 0.259 0.263 0.247 rg 0.0001 Tc 4.324 0 Td (in )Tj 0.2 0.2 0.188 rg 0.0082 Tc 1.118 0 Td (man. )Tj 0.259 0.263 0.247 rg /T1_1 1 Tf 0.0177 Tc 2.418 0 Td (Arch )Tj 0.2 0.2 0.188 rg -0.003 Tc 2.277 0 Td (Intern )Tj 0.259 0.263 0.247 rg 0.0141 Tc 2.811 0 Td (Med, )Tj 0.2 0.2 0.188 rg /T1_0 1 Tf -0.0325 Tc 2.53 0 Td (1932, )Tj 0.259 0.263 0.247 rg -0.0027 Tc 2.43 0 Td (49, )Tj 0.0119 Tc 1.573 0 Td (360-396. )Tj -0.035 Tc 7.3607 0 0 8.2 60.71 443.28 Tm (17. )Tj 0.2 0.2 0.188 rg 0.0207 Tc 8.2 0 0 8.2 77.73 443.28 Tm (West )Tj 0.259 0.263 0.247 rg -0.0338 Tc 2.456 0 Td (JB. )Tj 0.341 0.345 0.333 rg 0.05 Tc 9.5732 0 0 8.2 111.73 443.28 Tm (-Resp)Tj 0.2 0.2 0.188 rg 0.0369 Tc 8.2 0 0 8.2 135.77 443.28 Tm (iratory )Tj 0.259 0.263 0.247 rg -0.0001 Tc 3.229 0 Td (physiology. )Tj 0.05 Tc 8.2125 0 0 8.2 203.93 443.28 Tm (The )Tj 0.004 Tc 8.2 0 0 8.2 219.75 443.28 Tm (essentials. )Tj 0.2 0.2 0.188 rg 0.0049 Tc 4.456 0 Td (Williams )Tj 0.259 0.263 0.247 rg /T1_3 1 Tf 0 Tc 7.8001 0 0 7.8001 59.42 434.16 Tm (& )Tj /T1_0 1 Tf -0.0044 Tc 8.2 0 0 8.2 68.61 434.16 Tm (Wilins)Tj 0.4 0.404 0.392 rg 0 Tc 2.68 0 Td (, )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0058 Tc 8.2 0 0 8.2 95.4732 434.16 Tm (Baltimore, )Tj EMC ET BT /T1_0 1 Tf -0.0325 Tc 8.2 0 0 8.2 134.5954 434.16 Tm (1984, )Tj 0.259 0.263 0.247 rg -0.035 Tc 8.1587 0 0 8.2 154.57 434.16 Tm (p. )Tj 7.7728 0 0 8.2 164.37 434.16 Tm (185)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 175.51 434.16 Tm (. )Tj 0.259 0.263 0.247 rg -0.035 Tc 7.7937 0 0 8.2 60.21 425.53 Tm (18. )Tj 0.0378 Tc 8.2 0 0 8.2 77.68 425.53 Tm (Chadha )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0319 Tc 8.2 0 0 8.2 106.011 425.53 Tm (TS, )Tj EMC ET BT /T1_0 1 Tf 0.0098 Tc 8.2 0 0 8.2 120.3282 425.53 Tm (Schneider )Tj 0.0113 Tc 4.349 0 Td (AW, )Tj -0.0079 Tc 2.221 0 Td (Birch )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0105 Tc 8.2 0 0 8.2 194.2512 425.53 Tm (S, )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0183 Tc 8.2 0 0 8.2 202.9924 425.53 Tm (Jenouri )Tj 0.259 0.263 0.247 rg 0.0382 Tc 3.333 0 Td (G, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0255 Tc 8.2 0 0 8.2 240.8108 425.53 Tm (Sackner )Tj EMC ET BT /T1_0 1 Tf 0.0114 Tc 8.2 0 0 8.2 270.6834 425.53 Tm (MA. )Tj 0.4 0.404 0.392 rg 0 Tc -25.704 -1.112 Td (-)Tj 0.2 0.2 0.188 rg 0.0152 Tc 1.001 0 Td (Breathing )Tj 0.0369 Tc 4.455 0 Td (pattern )Tj 0.259 0.263 0.247 rg 0.03 Tc 3.384 0 Td (during )Tj 0.0024 Tc 3.221 0 Td (induced )Tj 0.0165 Tc 3.698 0 Td (bronchoconstriction. )Tj /T1_2 1 Tf 0 Tc 7.7 0 0 7.7 262.97 416.41 Tm (J )Tj /T1_1 1 Tf 0.036 Tc 8.2 0 0 8.2 270.85 416.41 Tm (App/ )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0171 Tc 8.2 0 0 8.2 60.0608 407.2834 Tm (Physio/: )Tj EMC ET BT /T1_1 1 Tf 0.0102 Tc 8.2 0 0 8.2 89.343 407.2834 Tm (Respirat )Tj -0.0216 Tc 3.805 0 Td (Environ )Tj 0.0005 Tc 3.454 0 Td (Exercise )Tj -0.0053 Tc 3.863 0 Td (Physiol, )Tj 0.2 0.2 0.188 rg /T1_0 1 Tf -0.035 Tc 7.8965 0 0 8.2 210.45 407.28 Tm (1984)Tj 0.341 0.345 0.333 rg 0 Tc 8.2 0 0 8.2 225.47 407.28 Tm (, )Tj 0.259 0.263 0.247 rg -0.0225 Tc 0.588 0 Td (56, )Tj ET BT /Suspect <>BDC 0.09 0.094 0.078 rg /T1_0 1 Tf 0 Tc 8.2 0 0 8.2 243.5592 407.28 Tm (1)Tj 0.259 0.263 0.247 rg -0.0075 Tc 0.376 0 Td (053)Tj 0.4 0.404 0.392 rg 0 Tc 1.521 0 Td (-)Tj 0.259 0.263 0.247 rg -0.0325 Tc 0.621 0 Td (1059. )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_0 1 Tf -0.0332 Tc 8.2 0 0 8.2 59.7234 398.1616 Tm (19. )Tj 0.259 0.263 0.247 rg 0.0134 Tc 2.199 0 Td (Askanazi )Tj 0.2 0.2 0.188 rg 0 Tc 4.034 0 Td (J)Tj 0.341 0.345 0.333 rg 0.459 0 Td (, )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0032 Tc 8.2 0 0 8.2 118.419 398.1616 Tm (Silverberg )Tj EMC /Suspect <>BDC 0.2 0.2 0.188 rg 0.0046 Tc 4.404 0 Td (PA, )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0307 Tc 8.2 0 0 8.2 169.8986 398.1616 Tm (Foster )Tj 0.0218 Tc 2.926 0 Td (RJ, )Tj 0.2 0.2 0.188 rg 0.0283 Tc 1.639 0 Td (Hyman )Tj 0.259 0.263 0.247 rg 0.05 Tc 8.2334 0 0 8.2 234.23 398.16 Tm (AI, )Tj 0.2 0.2 0.188 rg -0.0113 Tc 8.2 0 0 8.2 248.12 398.16 Tm (Milic)Tj 0.09 0.094 0.078 rg 0 Tc 2.101 0 Td (-)Tj 0.259 0.263 0.247 rg -0.0098 Tc 0.356 0 Td (Emili )Tj 0.0131 Tc -25.463 -1.052 Td (J, )Tj 0.2 0.2 0.188 rg 0.0091 Tc 1.172 0 Td (Kinney )Tj 0.0303 Tc 3.511 0 Td (JM. )Tj 0.341 0.345 0.333 rg 0 Tc 2.102 0 Td (-)Tj 0.2 0.2 0.188 rg -0.0251 Tc 1.117 0 Td (Effec)Tj 0.341 0.345 0.333 rg -0.0197 Tc 2.111 0 Td (ts )Tj 0.259 0.263 0.247 rg 0.05 Tc 9.4598 0 0 8.2 150.63 389.53 Tm (of )Tj 0.018 Tc 8.2 0 0 8.2 162.23 389.53 Tm (respiratory )Tj 0.0424 Tc 4.967 0 Td (apparatus )Tj 0.05 Tc 8.3916 0 0 8.2 240.88 389.53 Tm (on )Tj 0.0198 Tc 8.2 0 0 8.2 254.41 389.53 Tm (breathing )Tj 0.021 Tc -23.766 -1.112 Td (pattern. )Tj 0.2 0.2 0.188 rg /T1_2 1 Tf 0 Tc 8 0 0 8 89.21 380.41 Tm (J )Tj 0.259 0.263 0.247 rg /T1_1 1 Tf 0.036 Tc 8.2 0 0 8.2 96.61 380.41 Tm (Appl )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_1 1 Tf -0.0035 Tc 8.2 0 0 8.2 116.2162 380.41 Tm (Physiol)Tj 0.341 0.345 0.333 rg 0 Tc 2.961 0 Td (: )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_1 1 Tf 0.0102 Tc 8.2 0 0 8.2 145.974 380.41 Tm (Respirat )Tj -0.0021 Tc 3.805 0 Td (Environ )Tj -0.0078 Tc 3.629 0 Td (Exercise )Tj -0.0053 Tc 3.863 0 Td (Physiol, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.1597 0 0 8.2 269 380.41 Tm (1980)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 284.03 380.41 Tm (, )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf -0.0027 Tc 8.2 0 0 8.2 59.0138 371.759 Tm (48, )Tj -0.0305 Tc 1.571 0 Td (577)Tj 0.4 0.404 0.392 rg 0 Tc 1.466 0 Td (-)Tj 0.259 0.263 0.247 rg -0.0256 Tc 0.583 0 Td (580. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.8547 0 0 8.2 59.47 362.16 Tm (20. )Tj EMC ET BT /T1_0 1 Tf 0.0003 Tc 8.2 0 0 8.2 77.25 362.16 Tm (Weissman )Tj 0.0422 Tc 4.501 0 Td (C, )Tj 0.0134 Tc 1.296 0 Td (Askanazi )Tj 0.05 Tc 8.46 0 0 8.2 158.83 362.16 Tm (J, )Tj -0.0021 Tc 8.2 0 0 8.2 167.48 362.16 Tm (Milic-Emili )Tj 0.2 0.2 0.188 rg 0.0131 Tc 5.033 0 Td (J, )Tj 0.259 0.263 0.247 rg 0.0091 Tc 1.055 0 Td (Kinney )Tj 0.05 Tc 8.2597 0 0 8.2 244.27 362.16 Tm (JH.)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 259.59 362.16 Tm (-)Tj 0.259 0.263 0.247 rg -0.0052 Tc 0.883 0 Td (Effect )Tj 0.05 Tc 9.4598 0 0 8.2 58.95 353.53 Tm (of )Tj 0.018 Tc 8.2 0 0 8.2 69.59 353.53 Tm (respiratory )Tj 0.0424 Tc 4.909 0 Td (apparatus )Tj 0.05 Tc 8.3916 0 0 8.2 146.8 353.53 Tm (on )Tj 0.2 0.2 0.188 rg 0.02 Tc 8.2 0 0 8.2 158.87 353.53 Tm (respiration. )Tj 0.259 0.263 0.247 rg /T1_2 1 Tf 0 Tc 8 0 0 8 201.05 353.53 Tm (J )Tj /T1_1 1 Tf 0.0165 Tc 8.2 0 0 8.2 208.93 353.53 Tm (App/ )Tj -0.0171 Tc 2.333 0 Td (Physio/: )Tj 0.2 0.2 0.188 rg 0.0019 Tc 3.688 0 Td (Respirat )Tj 0.259 0.263 0.247 rg -0.0216 Tc -24.234 -1.112 Td (Environ )Tj 0.0005 Tc 3.454 0 Td (Exercise )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_1 1 Tf 0.0063 Tc 8.2 0 0 8.2 119.1072 344.4116 Tm (Physiol)Tj 0.4 0.404 0.392 rg 0 Tc 2.982 0 Td (, )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf -0.0325 Tc 8.2 0 0 8.2 149.0126 344.4116 Tm (1984, )Tj 0.0067 Tc 2.421 0 Td (57, )Tj 0.2 0.2 0.188 rg -0.0106 Tc 1.532 0 Td (475)Tj 0.4 0.404 0.392 rg 0 Tc 1.515 0 Td (-)Tj 0.259 0.263 0.247 rg -0.0124 Tc 0.534 0 Td (480. )Tj -0.0302 Tc -16.978 -1.055 Td (21. )Tj 0.2 0.2 0.188 rg 0.0078 Tc 2.226 0 Td (Loveridge )Tj 0.259 0.263 0.247 rg -0.035 Tc 7.8194 0 0 8.2 117.09 335.76 Tm (B, )Tj 0.0011 Tc 8.2 0 0 8.2 129.57 335.76 Tm (West )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf -0.0297 Tc 8.2 0 0 8.2 152.6038 335.76 Tm (P, )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0155 Tc 8.2 0 0 8.2 164.6332 335.76 Tm (Anthonisen )Tj 0.05 Tc 8.2852 0 0 8.2 209.8 335.76 Tm (NR, )Tj 0.2 0.2 0.188 rg 0.0196 Tc 8.2 0 0 8.2 229.88 335.76 Tm (Kryger )Tj 0.05 Tc 8.3674 0 0 8.2 259.16 335.76 Tm (MH. )Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 281.19 335.76 Tm (-)Tj 0.2 0.2 0.188 rg 0.0135 Tc -27.038 -1.111 Td (Breathin)Tj 0.341 0.345 0.333 rg 0 Tc 3.509 0 Td (g )Tj 0.259 0.263 0.247 rg 0.0262 Tc 0.829 0 Td (patterns )Tj -0.035 Tc 7.9356 0 0 8.2 125.22 326.65 Tm (in )Tj 0.2 0.2 0.188 rg 0.0259 Tc 8.2 0 0 8.2 133.93 326.65 Tm (patients )Tj 0.259 0.263 0.247 rg 0.0144 Tc 3.568 0 Td (with )Tj 0.0211 Tc 2.099 0 Td (chronic )Tj 0.0147 Tc 3.395 0 Td (obstructive )Tj 0.0233 Tc 4.928 0 Td (pulmonary )Tj -0.0116 Tc -23.133 -1.112 Td (disease. )Tj /T1_1 1 Tf 0.05 Tc 8.3646 0 0 8.2 87.49 317.53 Tm (Am )Tj 0.0144 Tc 8.2 0 0 8.2 102.3 317.53 Tm (Rev )Tj 0.0058 Tc 1.815 0 Td (Respir )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0204 Tc 8.2 0 0 8.2 141.6846 317.53 Tm (Dis, )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_0 1 Tf -0.035 Tc 8.1597 0 0 8.2 158.12 317.53 Tm (1984)Tj 0.341 0.345 0.333 rg 0 Tc 8.2 0 0 8.2 173.63 317.53 Tm (, )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf -0.035 Tc 7.9309 0 0 8.2 179.25 317.53 Tm (130, )Tj EMC ET BT /T1_0 1 Tf 0.0185 Tc 8.2 0 0 8.2 194.79 317.53 Tm (730-733. )Tj -0.0302 Tc -16.561 -1.054 Td (22. )Tj 0.0286 Tc 2.227 0 Td (Forster )Tj 0.2 0.2 0.188 rg -0.0296 Tc 3.339 0 Td (A. )Tj 0.4 0.404 0.392 rg 0 Tc 1.337 0 Td (-)Tj 0.259 0.263 0.247 rg -0.0014 Tc 0.94 0 Td (Influence )Tj 0.0117 Tc 4.095 0 Td (des )Tj 0.0186 Tc 1.639 0 Td (agents )Tj 0.0115 Tc 2.985 0 Td (anesthesiques )Tj 0.0105 Tc 5.972 0 Td (intraveineux )Tj 0.0455 Tc -22.601 -1.113 Td (sur )Tj ET BT /Suspect <>BDC 0.341 0.345 0.333 rg /T1_0 1 Tf 0 Tc 8.2 0 0 8.2 72.4214 299.7606 Tm (I)Tj 0.2 0.2 0.188 rg 0.232 0 Td (a )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0125 Tc 8.2 0 0 8.2 81.5808 299.7606 Tm (ventilation )Tj 0.4 0.404 0.392 rg 0 Tc 4.791 0 Td (-)Tj 0.259 0.263 0.247 rg 0.0112 Tc 0.939 0 Td (investigations )Tj 0.05 Tc 8.4273 0 0 8.2 178.57 299.76 Tm (par )Tj 0.2 0.2 0.188 rg 0.0105 Tc 8.2 0 0 8.2 193.44 299.76 Tm (une )Tj 0.259 0.263 0.247 rg -0.0059 Tc 1.872 0 Td (nouvelle )Tj 0.2 0.2 0.188 rg 0.0128 Tc 3.862 0 Td (methode )Tj 0.259 0.263 0.247 rg 0.0419 Tc 3.923 0 Td (non )Tj -0.0136 Tc -26.056 -1.111 Td (invasive. )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0225 Tc 8.2 0 0 8.2 90.1692 290.6498 Tm (These )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.05 Tc 8.2927 0 0 8.2 112.72 290.65 Tm (de )Tj 0.013 Tc 8.2 0 0 8.2 123.85 290.65 Tm (privat-docent. )Tj 0.0301 Tc 6.141 0 Td (Faculte )Tj 0.0026 Tc 3.448 0 Td (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0027 Tc 8.2 0 0 8.2 213.558 290.65 Tm (Medecine, )Tj EMC ET BT /T1_0 1 Tf 0.0065 Tc 8.2 0 0 8.2 251.032 290.65 Tm (Universite )Tj 0.2 0.2 0.188 rg 0.05 Tc 8.2927 0 0 8.2 58.48 282 Tm (de )Tj 0.259 0.263 0.247 rg 0.0084 Tc 8.2 0 0 8.2 69.04 282 Tm (Gcneve, )Tj -0.0325 Tc 3.78 0 Td (1984. )Tj -0.0302 Tc -5.065 -1.111 Td (23. )Tj 0.0366 Tc 2.163 0 Td (Tobin )Tj 0.0315 Tc 2.813 0 Td (MJ, )Tj 0.0378 Tc 1.868 0 Td (Chadha )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0319 Tc 8.2 0 0 8.2 142.9548 272.8898 Tm (TS, )Tj EMC ET BT /T1_0 1 Tf 0.0183 Tc 8.2 0 0 8.2 157.3786 272.8898 Tm (Jenouri )Tj 0.0386 Tc 3.333 0 Td (GA, )Tj 0.2 0.2 0.188 rg -0.0079 Tc 2.112 0 Td (Birch )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf -0.0324 Tc 8.2 0 0 8.2 222.0766 272.8898 Tm (SJ)Tj 0.4 0.404 0.392 rg 0 Tc 0.998 0 Td (, )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0159 Tc 8.2 0 0 8.2 234.147 272.8898 Tm (Gazeroglu )Tj 0.0354 Tc 4.571 0 Td (HB, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0255 Tc 8.2 0 0 8.2 58.3964 263.7632 Tm (Sackner )Tj EMC ET BT /T1_0 1 Tf 0.0114 Tc 8.2 0 0 8.2 89.704 263.7632 Tm (MA. )Tj 0.4 0.404 0.392 rg 0 Tc 2.452 0 Td (-)Tj 0.2 0.2 0.188 rg 0.0152 Tc 1.118 0 Td (Breathing )Tj 0.259 0.263 0.247 rg 0.0255 Tc 4.513 0 Td (pattern: )Tj -0.035 Tc 7.5852 0 0 8.2 187.16 263.76 Tm (2. )Tj 0.2 0.2 0.188 rg -0.0027 Tc 8.2 0 0 8.2 197.72 263.76 Tm (Diseased )Tj 0.259 0.263 0.247 rg 0.0014 Tc 4.088 0 Td (subjects. )Tj /T1_1 1 Tf -0.0114 Tc 4.093 0 Td (Chest, )Tj 0.2 0.2 0.188 rg /T1_0 1 Tf -0.0325 Tc -25.068 -0.994 Td (1983, )Tj 0.259 0.263 0.247 rg -0.0221 Tc 2.417 0 Td (84, )Tj 0.0177 Tc 1.533 0 Td (286-294. )Tj 0.014 Tc -4.098 -1.171 Td (24)Tj 0.4 0.404 0.392 rg 0 Tc 1.039 0 Td (. )Tj 0.259 0.263 0.247 rg -0.0145 Tc 1.245 0 Td (Maxwell )Tj 0.2 0.2 0.188 rg 0.05 Tc 8.7884 0 0 8.2 107.96 246.01 Tm (DL)Tj 0.341 0.345 0.333 rg 0 Tc 8.2 0 0 8.2 120.35 246.01 Tm (, )Tj 0.259 0.263 0.247 rg 0.0242 Tc 0.533 0 Td (Cover )Tj 0.0397 Tc 2.873 0 Td (D, )Tj 0.0119 Tc 1.346 0 Td (Hughes )Tj 0.0128 Tc 3.452 0 Td (JMB. )Tj ET BT /Suspect <>BDC 0.4 0.404 0.392 rg /T1_0 1 Tf 0 Tc 8.2 0 0 8.2 208.705 246.01 Tm (-)Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf -0.0169 Tc 8.2 0 0 8.2 216.4212 246.01 Tm (Effect )Tj 0.05 Tc 8.9033 0 0 8.2 238.48 246.01 Tm (of )Tj 0.2 0.2 0.188 rg 0.018 Tc 8.2 0 0 8.2 248.15 246.01 Tm (respiratory )Tj 0.259 0.263 0.247 rg 0.0424 Tc -23.189 -1.112 Td (apparatus )Tj 0.05 Tc 8.3916 0 0 8.2 94.48 236.89 Tm (on )Tj 0.0057 Tc 8.2 0 0 8.2 106.06 236.89 Tm (timing )Tj 0.045 Tc 2.92 0 Td (and )Tj 0.0326 Tc 1.873 0 Td (depth )Tj 0.05 Tc 8.9033 0 0 8.2 167.44 236.89 Tm (of )Tj 0.0094 Tc 8.2 0 0 8.2 177.13 236.89 Tm (breathing. )Tj /T1_1 1 Tf -0.0059 Tc 4.572 0 Td (Respir )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0053 Tc 8.2 0 0 8.2 238.138 236.89 Tm (Physiol, )Tj EMC ET BT /T1_0 1 Tf -0.0032 Tc 8.2 0 0 8.2 267.0758 236.89 Tm (1985, )Tj 0.05 Tc 8.2873 0 0 8.2 57.98 228.73 Tm (6!, )Tj -0.035 Tc 8.1639 0 0 8.2 70.99 228.73 Tm (255)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 82.95 228.73 Tm (-)Tj 0.2 0.2 0.188 rg -0.0112 Tc 0.532 0 Td (264. )Tj -0.0302 Tc -3.571 -1.171 Td (25. )Tj 0.259 0.263 0.247 rg 0.0081 Tc 2.284 0 Td (Rodenstein )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0393 Tc 8.2 0 0 8.2 118.0378 219.1278 Tm (DO, )Tj EMC ET BT /T1_0 1 Tf 0.0078 Tc 8.2 0 0 8.2 136.2746 219.1278 Tm (Mercenier )Tj 0 Tc 4.561 0 Td (C)Tj 0.4 0.404 0.392 rg 0.696 0 Td (, )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0078 Tc 8.2 0 0 8.2 185.122 219.1278 Tm (Staneseu )Tj EMC ET BT /T1_0 1 Tf 0.0381 Tc 8.2 0 0 8.2 218.3484 219.1278 Tm (DC. )Tj 0.4 0.404 0.392 rg 0 Tc 2.101 0 Td (-)Tj 0.2 0.2 0.188 rg 0.0133 Tc 0.94 0 Td (Influence )Tj 0.341 0.345 0.333 rg 0.05 Tc 8.9033 0 0 8.2 278.32 219.13 Tm (of )Tj 0.259 0.263 0.247 rg 0.0351 Tc 8.2 0 0 8.2 58.06 210.49 Tm (the )Tj 0.018 Tc 1.64 0 Td (respiratory )Tj 0.2 0.2 0.188 rg 0.0283 Tc 4.917 0 Td (route )Tj 0.259 0.263 0.247 rg 0.05 Tc 8.3916 0 0 8.2 132.4 210.49 Tm (on )Tj 0.0058 Tc 8.2 0 0 8.2 144.46 210.49 Tm (the )Tj 0.0054 Tc 1.64 0 Td (resting )Tj 0.0271 Tc 3.163 0 Td (breathing )Tj 0.0369 Tc 4.273 0 Td (pattern )Tj 0.0001 Tc 3.385 0 Td (in )Tj 0.0164 Tc 1.178 0 Td (humans. )Tj /T1_1 1 Tf 0.05 Tc 8.3646 0 0 8.2 58.21 201.37 Tm (Am )Tj 0.2 0.2 0.188 rg -0.0148 Tc 8.2 0 0 8.2 73.02 201.37 Tm (Rev )Tj 0.259 0.263 0.247 rg 0.0058 Tc 1.815 0 Td (Respir )Tj -0.0204 Tc 2.929 0 Td (Dis, )Tj 0.2 0.2 0.188 rg /T1_0 1 Tf -0.035 Tc 7.8965 0 0 8.2 128.85 201.37 Tm (1985)Tj 0.341 0.345 0.333 rg 0 Tc 8.2 0 0 8.2 143.87 201.37 Tm (, )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf -0.0327 Tc 8.2 0 0 8.2 149.4788 201.37 Tm (131, )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_0 1 Tf -0.035 Tc 7.7728 0 0 8.2 166.29 201.37 Tm (163)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 177.51 201.37 Tm (-)Tj 0.259 0.263 0.247 rg -0.035 Tc 7.9309 0 0 8.2 183.09 201.37 Tm (166. )Tj -0.0302 Tc 8.2 0 0 8.2 312.43 755.29 Tm (26. )Tj 0.0275 Tc 2.162 0 Td (Chausow )Tj 0.0338 Tc 4.165 0 Td (AM)Tj 0.4 0.404 0.392 rg 0 Tc 1.683 0 Td (, )Tj 0.2 0.2 0.188 rg 0.0127 Tc 0.538 0 Td (Banner )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0294 Tc 8.2 0 0 8.2 408.9522 755.29 Tm (AS. )Tj EMC ET BT 0.341 0.345 0.333 rg /T1_0 1 Tf 0.05 Tc 10.6667 0 0 8.2 423.24 755.29 Tm (-Co)Tj 0.2 0.2 0.188 rg 0.0296 Tc 8.2 0 0 8.2 440.14 755.29 Tm (mparison )Tj 0.259 0.263 0.247 rg 0.05 Tc 8.9033 0 0 8.2 474.64 755.29 Tm (of )Tj 0.0062 Tc 8.2 0 0 8.2 483.82 755.29 Tm (tussive )Tj -0.0109 Tc 3.035 0 Td (effects )Tj 0.05 Tc 8.9033 0 0 8.2 532.24 755.29 Tm (of )Tj 0.0127 Tc 8.2 0 0 8.2 312.47 746.65 Tm (histamine )Tj 0.0157 Tc 4.323 0 Td (and )Tj 0.0071 Tc 1.88 0 Td (methylcholine )Tj 0.0001 Tc 6.14 0 Td (in )Tj 0.0164 Tc 1.178 0 Td (humans. )Tj 0.2 0.2 0.188 rg /T1_2 1 Tf 0 Tc 7.7 0 0 7.7 454.49 746.65 Tm (J )Tj 0.259 0.263 0.247 rg /T1_1 1 Tf 0.036 Tc 8.2 0 0 8.2 461.89 746.65 Tm (Appl )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0087 Tc 8.2 0 0 8.2 481.0206 746.65 Tm (Physio/: )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_1 1 Tf 0.0102 Tc 8.2 0 0 8.2 511.2622 746.65 Tm (Respirat )Tj 0.259 0.263 0.247 rg -0.0216 Tc -24.234 -1.112 Td (Environ )Tj 0.0005 Tc 3.454 0 Td (Exercise )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0136 Tc 8.2 0 0 8.2 372.0672 737.5316 Tm (Physiol, )Tj EMC ET BT /T1_0 1 Tf -0.0325 Tc 8.2 0 0 8.2 401.4888 737.5316 Tm (1983, )Tj /T1_1 1 Tf -0.035 Tc 8.1022 0 0 8.2 421.84 737.53 Tm (55)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 430.11 737.53 Tm (, )Tj 0.2 0.2 0.188 rg /T1_0 1 Tf -0.035 Tc 7.9095 0 0 8.2 434.29 737.53 Tm (541)Tj 0.341 0.345 0.333 rg 0.05 Tc 9.4995 0 0 8.2 446.29 737.53 Tm (-5)Tj 0.2 0.2 0.188 rg -0.032 Tc 8.2 0 0 8.2 455.01 737.53 Tm (46. )Tj 0.259 0.263 0.247 rg -0.0302 Tc -17.446 -1.054 Td (27. )Tj 0.0376 Tc 2.221 0 Td (O'Byme )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0382 Tc 8.2 0 0 8.2 361.407 728.8872 Tm (PM, )Tj EMC ET BT /T1_0 1 Tf 0.0146 Tc 8.2 0 0 8.2 378.6844 728.8872 Tm (Dolovich )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0423 Tc 8.2 0 0 8.2 412.7636 728.8872 Tm (M, )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0343 Tc 8.2 0 0 8.2 425.244 728.8872 Tm (Dirks )Tj 0.0229 Tc 2.693 0 Td (R, )Tj 0.0287 Tc 1.346 0 Td (Roberts )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0261 Tc 8.2 0 0 8.2 488.1216 728.8872 Tm (RS, )Tj EMC ET BT /T1_0 1 Tf 0.0245 Tc 8.2 0 0 8.2 503.5622 728.8872 Tm (Newhouse )Tj 0.05 Tc 10.1556 0 0 8.2 311.47 719.76 Tm (MT.-)Tj 0.0227 Tc 8.2 0 0 8.2 336.44 719.76 Tm (Lung )Tj 0.0058 Tc 2.394 0 Td (epithelial )Tj 0.0059 Tc 4.051 0 Td (permeability: )Tj 0.0159 Tc 5.676 0 Td (relation )Tj 0.2 0.2 0.188 rg -0.0137 Tc 3.511 0 Td (to )Tj 0.0419 Tc 1.113 0 Td (non)Tj 0.09 0.094 0.078 rg 0 Tc 1.571 0 Td (-)Tj 0.259 0.263 0.247 rg -0.0135 Tc 0.348 0 Td (specific )Tj 0.0206 Tc 3.224 0 Td (airway )Tj -0.0028 Tc -24.811 -1.111 Td (responsiveness. )Tj /T1_1 1 Tf 0 Tc 6.568 0 Td (J )Tj 0.0165 Tc 0.824 0 Td (App/ )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0087 Tc 8.2 0 0 8.2 391.257 710.6498 Tm (Physio/: )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_1 1 Tf 0.05 Tc 8.2906 0 0 8.2 421.5 710.65 Tm (Re)Tj 0.341 0.345 0.333 rg -0.0003 Tc 8.2 0 0 8.2 430.11 710.65 Tm (spira)Tj 0.2 0.2 0.188 rg 0 Tc 2.091 0 Td (t )Tj 0.259 0.263 0.247 rg -0.0118 Tc 0.605 0 Td (Environ )Tj 0.0089 Tc 3.512 0 Td (Exercise )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0053 Tc 8.2 0 0 8.2 512.6922 710.65 Tm (Physio/, )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_0 1 Tf -0.0325 Tc 8.2 0 0 8.2 312.6696 701.999 Tm (1984, )Tj 0.259 0.263 0.247 rg -0.035 Tc 7.9596 0 0 8.2 333.01 702 Tm (57, )Tj 8.1668 0 0 8.2 345.51 702 Tm (77)Tj 0.4 0.404 0.392 rg 0 Tc 8.2 0 0 8.2 353.19 702 Tm (-)Tj 0.259 0.263 0.247 rg -0.0221 Tc 0.579 0 Td (84. )Tj -0.035 Tc 8.1176 0 0 8.2 311.95 692.89 Tm (28)Tj 0.09 0.094 0.078 rg 0 Tc 8.2 0 0 8.2 319.99 692.89 Tm (. )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0208 Tc 8.2 0 0 8.2 330.199 692.89 Tm (Pardy )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0284 Tc 8.2 0 0 8.2 355.1598 692.89 Tm (RL, )Tj 0.259 0.263 0.247 rg 0.0129 Tc 2.224 0 Td (Rivington )Tj 0.05 Tc 8.2964 0 0 8.2 412.28 692.89 Tm (RN, )Tj 0.2 0.2 0.188 rg -0.0021 Tc 8.2 0 0 8.2 431.48 692.89 Tm (Milic-Emili )Tj -0.0169 Tc 8.6 0 0 8.6 475.15 692.89 Tm (J, )Tj 0.259 0.263 0.247 rg 0.0409 Tc 8.2 0 0 8.2 485.72 692.89 Tm (Mortola )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.2061 0 0 8.2 518.83 692.89 Tm (JP. )Tj EMC ET BT 0.341 0.345 0.333 rg /T1_0 1 Tf 0 Tc 8.2 0 0 8.2 534.63 692.89 Tm (-)Tj 0.259 0.263 0.247 rg 0.0314 Tc -27.16 -1.055 Td (Control )Tj 0.05 Tc 9.4598 0 0 8.2 343.11 684.24 Tm (of )Tj 0.0198 Tc 8.2 0 0 8.2 355.21 684.24 Tm (breathing )Tj 0.2 0.2 0.188 rg 0.0001 Tc 4.498 0 Td (in )Tj 0.259 0.263 0.247 rg 0.0308 Tc 1.287 0 Td (chronic )Tj 0.0206 Tc 3.688 0 Td (obstructive )Tj 0.0176 Tc 5.211 0 Td (lung )Tj -0.0032 Tc 2.399 0 Td (disease. )Tj 0.05 Tc 8.2125 0 0 8.2 525.53 684.24 Tm (The )Tj -0.0173 Tc 8.2 0 0 8.2 311.91 675.12 Tm (effect )Tj 0.05 Tc 8.9033 0 0 8.2 334.48 675.12 Tm (of )Tj 0.02 Tc 8.2 0 0 8.2 345.59 675.12 Tm (histamine )Tj 0.0221 Tc 4.559 0 Td (inhalation. )Tj /T1_1 1 Tf 0.05 Tc 8.3646 0 0 8.2 424.45 675.12 Tm (Am )Tj 0.2 0.2 0.188 rg 0.0437 Tc 8.2 0 0 8.2 440.7 675.12 Tm (Rev )Tj 0.0058 Tc 2.107 0 Td (Respir )Tj 0.259 0.263 0.247 rg -0.0204 Tc 3.222 0 Td (Dis, )Tj /T1_0 1 Tf -0.0178 Tc 2.239 0 Td (1981, )Tj -0.0327 Tc 2.81 0 Td (125, )Tj 0.0415 Tc -26.085 -1.054 Td (6-11. )Tj -0.0302 Tc 0.006 -1.112 Td (29. )Tj -0.0008 Tc 2.162 0 Td (Oliven )Tj 0.0289 Tc 2.994 0 Td (A, )Tj 0.0235 Tc 1.221 0 Td (Cherniak )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0262 Tc 8.2 0 0 8.2 397.9616 657.3588 Tm (NS, )Tj EMC ET BT /T1_0 1 Tf 0.0016 Tc 8.2 0 0 8.2 413.2382 657.3588 Tm (Deal )Tj 0.259 0.263 0.247 rg 0.0247 Tc 2.223 0 Td (EC)Tj 0.4 0.404 0.392 rg 0 Tc 1.278 0 Td (, )Tj 0.2 0.2 0.188 rg -0.0041 Tc 0.538 0 Td (Kelsen )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.05 Tc 9.9573 0 0 8.2 471.66 657.36 Tm (SG.-)Tj EMC ET BT /T1_0 1 Tf 8.2125 0 0 8.2 493.37 657.36 Tm (The )Tj -0.0109 Tc 8.2 0 0 8.2 508.71 657.36 Tm (effects )Tj 0.05 Tc 8.9033 0 0 8.2 532.24 657.36 Tm (of )Tj 0.0177 Tc 8.2 0 0 8.2 311.92 648.24 Tm (acute )Tj 0.0183 Tc 2.587 0 Td (bronchoconstriction )Tj 0.05 Tc 8.3916 0 0 8.2 404.08 648.24 Tm (on )Tj 0.018 Tc 8.2 0 0 8.2 416.15 648.24 Tm (respiratory )Tj 0.0171 Tc 4.85 0 Td (activity )Tj 0.05 Tc 8.2876 0 0 8.2 484.25 648.24 Tm (in )Tj 0.0175 Tc 8.2 0 0 8.2 494.41 648.24 Tm (patients )Tj -0.0052 Tc 3.627 0 Td (with )Tj 0.0308 Tc -25.94 -1.052 Td (chronic )Tj 0.0206 Tc 3.454 0 Td (obstructive )Tj 0.0233 Tc 4.987 0 Td (pulmonary )Tj -0.0116 Tc 4.848 0 Td (disease. )Tj /T1_1 1 Tf 0.05 Tc 8.3646 0 0 8.2 449.41 639.61 Tm (Am )Tj 0.2 0.2 0.188 rg 0.0144 Tc 8.2 0 0 8.2 464.22 639.61 Tm (Rev )Tj 0.259 0.263 0.247 rg 0.0058 Tc 1.932 0 Td (Respir )Tj -0.0204 Tc 2.988 0 Td (Dis, )Tj /T1_0 1 Tf -0.0178 Tc 2.063 0 Td (1985, )Tj 0.2 0.2 0.188 rg -0.035 Tc 7.0662 0 0 8.2 312.72 630.48 Tm (131)Tj 0.341 0.345 0.333 rg 0 Tc 8.2 0 0 8.2 323.87 630.48 Tm (, )Tj 0.259 0.263 0.247 rg -0.0088 Tc 0.537 0 Td (236)Tj 0.4 0.404 0.392 rg 0 Tc 1.517 0 Td (-)Tj 0.259 0.263 0.247 rg -0.0307 Tc 0.532 0 Td (241. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0299 Tc 8.2 0 0 8.2 311.9636 612.727 Tm (RESUME: )Tj EMC ET BT /T1_0 1 Tf 0.0198 Tc 8.2 0 0 8.2 351.8074 612.727 Tm (L'histamine )Tj 0.05 Tc 8.3173 0 0 8.2 393.51 612.73 Tm (et )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8.2 402.19 612.73 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0071 Tc 8.2 0 0 8.2 410.38 612.73 Tm (methylcholine )Tj 0.05 Tc 8.4919 0 0 8.2 460.24 612.73 Tm (ont )Tj 0.0117 Tc 8.2 0 0 8.2 474.16 612.73 Tm (des )Tj 0.0047 Tc 1.579 0 Td (etfets )Tj 0.0114 Tc 2.401 0 Td (differents )Tj 0.0455 Tc -23.829 -1.054 Td (sur )Tj 0.2 0.2 0.188 rg -0.035 Tc 7.9707 0 0 8.2 324.41 604.09 Tm (les )Tj 0.259 0.263 0.247 rg 0.0123 Tc 8.2 0 0 8.2 335.03 604.09 Tm (recepteurs )Tj 0.0093 Tc 4.448 0 Td (vagaux )Tj 0.0159 Tc 3.223 0 Td (bronchiques )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 12.4 0 0 12.4 440.99 604.09 Tm (a )Tj EMC ET BT /T1_0 1 Tf 0.0264 Tc 8.2 0 0 8.2 447.09 604.09 Tm (!'irritation. )Tj 0.2 0.2 0.188 rg 0.05 Tc 8.3613 0 0 8.2 486.67 604.09 Tm (La )Tj 0.259 0.263 0.247 rg 0.0128 Tc 8.2 0 0 8.2 498.25 604.09 Tm (premiere )Tj -0.02 Tc 3.912 0 Td (les )Tj 0.0118 Tc -26.699 -1.112 Td (stimule )Tj 0.05 Tc 8.4273 0 0 8.2 337.93 594.97 Tm (par )Tj 0.2 0.2 0.188 rg 0.0105 Tc 8.2 0 0 8.2 351.36 594.97 Tm (une )Tj 0.259 0.263 0.247 rg 0.0176 Tc 1.688 0 Td (action )Tj 0.0154 Tc 2.751 0 Td (chimique )Tj 0.0074 Tc 4.039 0 Td (directe )Tj 0.0022 Tc 2.984 0 Td (et )Tj 0.017 Tc 0.998 0 Td (indirectement )Tj 0.2 0.2 0.188 rg 0.05 Tc 8.4273 0 0 8.2 502.09 594.97 Tm (par )Tj 0.259 0.263 0.247 rg -0.0023 Tc 8.2 0 0 8.2 515.45 594.97 Tm (le )Tj 0.0138 Tc 0.946 0 Td (biais )Tj 0.05 Tc 8.2998 0 0 8.2 311.44 585.85 Tm (du )Tj 0.0166 Tc 8.2 0 0 8.2 323.05 585.85 Tm (bronchospasme, )Tj 0.2 0.2 0.188 rg 0.0176 Tc 7.073 0 Td (landis )Tj 0.259 0.263 0.247 rg 0.0446 Tc 2.809 0 Td (que )Tj ET BT /Suspect <>BDC /C0_0 1 Tf 0 Tc 3.12 0 0 6.24 419.05 585.85 Tm <006C007E>Tj 0.612 0.616 0.6 rg 1.92 0 0 6.24 425.77 585.85 Tm <005F>Tj 0.259 0.263 0.247 rg 3.84 0 0 6.24 427.68 585.85 Tm <007300650063006F006E006400650020>Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.6579 0 0 8.2 457.43 585.85 Tm (n'a )Tj 8.3045 0 0 8.2 470.8 585.85 Tm (qu'un )Tj 0.0007 Tc 8.2 0 0 8.2 493.35 585.85 Tm (etfet )Tj 0.0066 Tc 2.11 0 Td (indirect. )Tj -0.0039 Tc -24.285 -1.054 Td (Afin )Tj 0.05 Tc 8.2927 0 0 8.2 328.72 577.21 Tm (de )Tj 0.0142 Tc 8.2 0 0 8.2 339.82 577.21 Tm (tenter )Tj 0.016 Tc (d'identifier )Tj 0.2 0.2 0.188 rg -0.0023 Tc 7.428 0 Td (le )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf -0.0102 Tc 8.2 0 0 8.2 409.4298 577.21 Tm (role )Tj EMC /Suspect <>BDC 0.725 0.729 0.714 rg 0 Tc 1.737 0 Td (\267)Tj 0.259 0.263 0.247 rg 0.0026 Tc 0.128 0 Td (de )Tj EMC ET BT /T1_0 1 Tf -0.0128 Tc 8.2 0 0 8.2 434.8006 577.21 Tm (ces )Tj 0.0006 Tc 1.58 0 Td (afferences )Tj 0.2 0.2 0.188 rg 0.0362 Tc 4.39 0 Td (dans )Tj -0.035 Tc 7.8836 0 0 8.2 502.49 577.21 Tm (le )Tj 0.259 0.263 0.247 rg 0.037 Tc 8.2 0 0 8.2 510.16 577.21 Tm (controle )Tj 0.0129 Tc -24.227 -1.112 Td (ventilatoire )Tj 0.0019 Tc 5.32 0 Td (chez )Tj 0.0166 Tc 2.518 0 Td (l'homme, )Tj 0.0348 Tc 4.515 0 Td (nous )Tj 0.0198 Tc 2.626 0 Td (avons )Tj 0.0351 Tc 3.102 0 Td (compare )Tj -0.035 Tc 7.9707 0 0 8.2 495.29 568.09 Tm (les )Tj 0.0106 Tc 8.2 0 0 8.2 509.27 568.09 Tm (reponses )Tj 0.013 Tc -24.117 -1.112 Td (respiratoires )Tj 0.05 Tc 8.3101 0 0 8.2 356.08 558.97 Tm (au )Tj 0.2 0.2 0.188 rg 0.0193 Tc 8.2 0 0 8.2 367.69 558.97 Tm (bronchospasme )Tj 0.259 0.263 0.247 rg 0.017 Tc 6.839 0 Td (induit )Tj 0.05 Tc 8.4273 0 0 8.2 446.89 558.97 Tm (par )Tj 0.2 0.2 0.188 rg 0.0263 Tc 8.2 0 0 8.2 461.21 558.97 Tm (inhalation )Tj 0.259 0.263 0.247 rg 0.0246 Tc 4.623 0 Td (d'histamine )Tj 0.0155 Tc -22.888 -1.112 Td (ou )Tj 0.0026 Tc 1.639 0 Td (de )Tj 0.0071 Tc 1.529 0 Td (methylcholine )Tj 0.0019 Tc 6.373 0 Td (chez )Tj -0.0176 Tc 2.4 0 Td (des )Tj 0.0066 Tc 1.868 0 Td (sujets )Tj 0.0425 Tc 2.882 0 Td (normaux )Tj 0.05 Tc 8.3173 0 0 8.2 483.75 549.85 Tm (et )Tj -0.0176 Tc 8.2 0 0 8.2 495.28 549.85 Tm (des )Tj 0.2 0.2 0.188 rg 0.0071 Tc 1.93 0 Td (fumeurs )Tj 0.259 0.263 0.247 rg 0.0135 Tc -24.35 -1.054 Td (asymptomatiques. )Tj 0.0129 Tc 7.849 0 Td (Le )Tj 0.0061 Tc 1.341 0 Td (choix )Tj 0.0479 Tc 2.576 0 Td (d'un )Tj 0.0214 Tc 2.167 0 Td (groupe )Tj 0.0026 Tc 3.218 0 Td (de )Tj 0.0168 Tc 1.287 0 Td (fumeurs )Tj 0.0128 Tc 3.684 0 Td (se )Tj 0.0139 Tc 1.033 0 Td (justifie )Tj 0.2 0.2 0.188 rg 0.05 Tc 8.4273 0 0 8.2 527.05 541.21 Tm (par )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0185 Tc 8.2 0 0 8.2 311.25 532.56 Tm (!'hypothese )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0394 Tc 8.2 0 0 8.2 353.2012 532.56 Tm (qu'une )Tj 0.259 0.263 0.247 rg 0.0336 Tc 3.22 0 Td (augmentation )Tj 0.0026 Tc 6.146 0 Td (de )Tj 0.0155 Tc 1.357 0 Td (permeabilite )Tj 0.05 Tc 8.2927 0 0 8.2 486.64 532.56 Tm (de )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0129 Tc 8.2 0 0 8.2 497.97 532.56 Tm (!'epithelium )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0218 Tc 8.2 0 0 8.2 311.5266 523.4416 Tm (bronchique )Tj 0.0271 Tc 4.906 0 Td (devrait )Tj -0.0025 Tc 3.218 0 Td (faciliter )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0052 Tc 8.2 0 0 8.2 406.4826 523.4416 Tm (l'acces )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.2927 0 0 8.2 430 523.44 Tm (de )Tj 0.0237 Tc 8.2 0 0 8.2 440.37 523.44 Tm (!'histamine )Tj 0.2 0.2 0.188 rg -0.0068 Tc 4.889 0 Td (vers )Tj 0.259 0.263 0.247 rg -0.02 Tc 1.926 0 Td (les )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0184 Tc 8.2 0 0 8.2 507.3394 523.44 Tm (terminai\255)Tj EMC ET BT /T1_0 1 Tf 0.0206 Tc 8.2 0 0 8.2 310.9166 514.3298 Tm (sons )Tj 0.0031 Tc 2.238 0 Td (nerveuses, )Tj 0.0115 Tc 4.616 0 Td (accro!tre )Tj -0.0004 Tc 4.039 0 Td (ainsi )Tj 0.0206 Tc 2.278 0 Td (son )Tj 0.0176 Tc 1.878 0 Td (action )Tj 0.0171 Tc 2.927 0 Td (directe )Tj 0.05 Tc 8.3173 0 0 8.2 484.71 514.33 Tm (et )Tj 0.036 Tc 8.2 0 0 8.2 493.93 514.33 Tm (produire )Tj 0.05 Tc 8.4273 0 0 8.2 527.05 514.33 Tm (par )Tj 0.0166 Tc 8.2 0 0 8.2 310.96 505.69 Tm (consequent )Tj 0.0117 Tc 5.151 0 Td (des )Tj 0.0047 Tc 1.813 0 Td (elfets )Tj 0.0049 Tc 2.635 0 Td (differents )Tj 0.0026 Tc 4.39 0 Td (de )Tj 0.0024 Tc 1.405 0 Td (ceux )Tj 0.0361 Tc 2.4 0 Td (attendus )Tj 0.2 0.2 0.188 rg 0.0019 Tc 4.098 0 Td (chez )Tj 0.259 0.263 0.247 rg -0.035 Tc 7.9707 0 0 8.2 509.69 505.69 Tm (les )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.034 Tc 8.2 0 0 8.2 522.71 505.69 Tm (non\255)Tj EMC ET BT /T1_0 1 Tf 0.0122 Tc 8.2 0 0 8.2 310.9532 496.5634 Tm (fumeurs, )Tj 0.0022 Tc 4.039 0 Td (et )Tj 0.0049 Tc 1.113 0 Td (differents )Tj 0.0026 Tc 4.273 0 Td (de )Tj 0.0024 Tc 1.346 0 Td (ceux )Tj 0.0079 Tc 2.343 0 Td (induits )Tj 0.05 Tc 8.4273 0 0 8.2 444.97 496.56 Tm (par )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8.2 459.79 496.56 Tm (Ia )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0054 Tc 8.2 0 0 8.2 468.94 496.56 Tm (methylcholine. )Tj 0.05 Tc 8.2722 0 0 8.2 522.68 496.56 Tm (Huit )Tj 0.0066 Tc 8.2 0 0 8.2 310.92 487.44 Tm (sujets )Tj 0.2 0.2 0.188 rg 0.0328 Tc 2.823 0 Td (normaux )Tj 0.259 0.263 0.247 rg 0.05 Tc 8.9571 0 0 8.2 368.55 487.44 Tm (et )Tj 0.0184 Tc 8.2 0 0 8.2 379.08 487.44 Tm (sept )Tj -0.0027 Tc 2.228 0 Td (fumeurs )Tj 0.024 Tc 3.806 0 Td (asymptomatiques )Tj 0.0224 Tc 7.843 0 Td (furent )Tj -0.0012 Tc 3.052 0 Td (testes. )Tj 0.0044 Tc -25.173 -1.111 Td (L'experience )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0293 Tc 8.2 0 0 8.2 358.4652 478.3298 Tm (etait )Tj EMC /Suspect <>BDC -0.0027 Tc 2.459 0 Td (executee )Tj EMC ET BT /T1_0 1 Tf 0.0455 Tc 8.2 0 0 8.2 411.716 478.3298 Tm (sur )Tj 0.0187 Tc 1.878 0 Td (deux )Tj 0.2 0.2 0.188 rg 0.05 Tc 8.3013 0 0 8.2 448.04 478.33 Tm (jours )Tj 0.259 0.263 0.247 rg 0.0029 Tc 8.2 0 0 8.2 470.8 478.33 Tm (differents, )Tj 0.0059 Tc 4.737 0 Td (selon )Tj -0.035 Tc 7.9307 0 0 8.2 532.27 478.33 Tm (Ia )Tj 0.2 0.2 0.188 rg 0.0125 Tc 8.2 0 0 8.2 311.02 469.69 Tm (technique )Tj 0.259 0.263 0.247 rg 0.05 Tc 8.2998 0 0 8.2 346.48 469.69 Tm (du )Tj 0.0287 Tc 8.2 0 0 8.2 358.48 469.69 Tm (controle )Tj 0.0032 Tc 3.746 0 Td (croise. )Tj 0.0378 Tc 3.044 0 Td (Chaque )Tj 0.0476 Tc 3.545 0 Td (jour, )Tj -0.0023 Tc 2.427 0 Td (le )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0326 Tc 8.2 0 0 8.2 471.8204 469.69 Tm (VEMS )Tj EMC ET BT /T1_0 1 Tf 0.0142 Tc 8.2 0 0 8.2 498.1588 469.69 Tm (ainsi )Tj 0.2 0.2 0.188 rg 0.0446 Tc 2.283 0 Td (que )Tj 0.259 0.263 0.247 rg -0.0023 Tc 1.933 0 Td (le )Tj 0.0105 Tc -27.038 -1.113 Td (volume )Tj 0.0308 Tc 3.388 0 Td (courant )Tj -0.035 Tc 8.0418 0 0 8.2 368.55 460.56 Tm (\(VT\), )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf 7.9307 0 0 8.2 388.75 460.56 Tm (Ia )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0029 Tc 8.2 0 0 8.2 397.83 460.56 Tm (frequence )Tj 0.0398 Tc 7.7 0 0 7.7 433.83 460.56 Tm (\(f\) )Tj 0.05 Tc 8.3173 0 0 8.2 444.87 460.56 Tm (et )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8.2 454.51 460.56 Tm (Ia )Tj EMC /Suspect <>BDC 0.0329 Tc 8.2 0 0 8.2 463.6 460.56 Tm (duree )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.2927 0 0 8.2 485.68 460.56 Tm (de )Tj 0.0214 Tc 8.2 0 0 8.2 497.01 460.56 Tm (!'inspiration )Tj -0.004 Tc -22.691 -1.052 Td (\(Tt\) )Tj 0.0283 Tc 2.109 0 Td (etaient )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0149 Tc 8.2 0 0 8.2 356.0848 451.9336 Tm (determines )Tj EMC ET BT /T1_0 1 Tf 0.0127 Tc 8.2 0 0 8.2 397.8556 451.9336 Tm (lors )Tj 0.05 Tc 8.2927 0 0 8.2 415.12 451.93 Tm (de )Tj 0 Tc 8.2 0 0 8.2 428.62 451.93 Tm (t)Tj 0.09 0.094 0.078 rg 0.294 0 Td (r)Tj 0.259 0.263 0.247 rg 0.0126 Tc 0.343 0 Td (ois )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.043 Tc 8.2 0 0 8.2 448.2344 451.93 Tm (eta )Tj EMC ET BT /T1_0 1 Tf 0.0117 Tc 8.2 0 0 8.2 458.8944 451.93 Tm (pes )Tj -0.0158 Tc 1.916 0 Td (successives: )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf -0.0074 Tc 8.2 0 0 8.2 519.7876 451.93 Tm (I\) )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0133 Tc 8.2 0 0 8.2 530.3164 451.93 Tm (en )Tj 0.021 Tc -26.809 -1.112 Td (condition )Tj 0.0079 Tc 4.226 0 Td (basale; )Tj 0.0054 Tc 3.037 0 Td (2\) )Tj 0.0133 Tc 1.049 0 Td (en )Tj 0.0283 Tc 1.172 0 Td (condition )Tj 0.0026 Tc 4.215 0 Td (de )Tj 0.2 0.2 0.188 rg 0.0203 Tc 1.171 0 Td (controle )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0172 Tc 8.2 0 0 8.2 462.6582 442.8116 Tm (apres )Tj EMC ET BT /T1_0 1 Tf 0.0263 Tc 8.2 0 0 8.2 482.3464 442.8116 Tm (inhalation )Tj 0.0422 Tc 4.506 0 Td (d'une )Tj 0.0286 Tc -25.468 -1.112 Td (solution )Tj 0.0193 Tc 3.922 0 Td (saline )Tj 0.014 Tc 2.991 0 Td (isotonique )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0158 Tc 8.2 0 0 8.2 407.0376 433.6932 Tm (tamponnee; )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf -0.035 Tc 8.1987 0 0 8.2 451.59 433.69 Tm (3\) )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0172 Tc 8.2 0 0 8.2 462.64 433.69 Tm (apres )Tj EMC ET BT /T1_0 1 Tf 0.0205 Tc 8.2 0 0 8.2 485.6902 433.69 Tm (induction )Tj 0.05 Tc 8.435 0 0 8.2 522.64 433.69 Tm (d'un )Tj 0.0193 Tc 8.2 0 0 8.2 311.05 425.05 Tm (bronchospasme )Tj 0.0397 Tc 6.849 0 Td (par )Tj 0.0263 Tc 1.688 0 Td (inhalation )Tj 0.0305 Tc 4.565 0 Td (d'histamine )Tj 0.05 Tc 8.3916 0 0 8.2 461.2 425.05 Tm (ou )Tj 0.2 0.2 0.188 rg 0.012 Tc 8.2 0 0 8.2 473.26 425.05 Tm (methylcholine)Tj 0.341 0.345 0.333 rg 0 Tc 5.835 0 Td (. )Tj 0.259 0.263 0.247 rg -0.0124 Tc 0.66 0 Td (Les )Tj 0.0215 Tc -26.335 -1.112 Td (parametres )Tj 0.013 Tc 5.032 0 Td (respiratoires )Tj 0.0283 Tc 5.493 0 Td (etaient )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf -0.0146 Tc 8.2 0 0 8.2 423.3466 415.9316 Tm (mesuri:s )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.05 Tc 8.2927 0 0 8.2 453.52 415.93 Tm (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0112 Tc 8.2 0 0 8.2 465.03 415.93 Tm (facon )Tj EMC ET BT /T1_0 1 Tf 0.0046 Tc 8.2 0 0 8.2 487.6702 415.93 Tm (non-invasive )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 12.4 0 0 12.4 534.11 415.93 Tm (a )Tj EMC ET BT /T1_0 1 Tf 0.0231 Tc 8.2 0 0 8.2 310.29 406.81 Tm (!'aide )Tj 0.0026 Tc 2.54 0 Td (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0003 Tc 8.2 0 0 8.2 341.2204 406.81 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0125 Tc 8.2 0 0 8.2 349.9042 406.81 Tm (technique )Tj 0.0117 Tc 4.207 0 Td (des )Tj 0.0198 Tc 1.65 0 Td (pneumographes )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 12.8 0 0 12.8 453.95 406.81 Tm (a )Tj EMC ET BT /T1_0 1 Tf 0.0002 Tc 8.2 0 0 8.2 460.2 406.81 Tm (soufflet. )Tj 0.05 Tc 8.3613 0 0 8.2 490.03 406.81 Tm (La )Tj 0.0125 Tc 8.2 0 0 8.2 501.58 406.81 Tm (ventilation )Tj 0.05 Tc 8.4273 0 0 8.2 310.57 397.69 Tm (par )Tj 0.0197 Tc 8.2 0 0 8.2 323.98 397.69 Tm (minute )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.812 0 0 8 349.35 397.69 Tm (\(VE\), )Tj EMC ET BT 0.2 0.2 0.188 rg /T1_0 1 Tf 7.8836 0 0 8.2 368.09 397.69 Tm (le )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0152 Tc 8.2 0 0 8.2 375.28 397.69 Tm (debit )Tj EMC ET BT /T1_0 1 Tf 0.019 Tc 8.2 0 0 8.2 394.49 397.69 Tm (inspiratoire )Tj 0.259 0.263 0.247 rg 0.0157 Tc 4.982 0 Td (moyen, )Tj 0.0051 Tc 3.272 0 Td (index )Tj 0.05 Tc 8.2927 0 0 8.2 482.32 397.69 Tm (de )Tj 0.2 0.2 0.188 rg -0.035 Tc 7.9307 0 0 8.2 492.43 397.69 Tm (Ia )Tj 0.259 0.263 0.247 rg 0.029 Tc 8.2 0 0 8.2 500.08 397.69 Tm (commande )Tj 0.2 0.2 0.188 rg 0.0176 Tc -23.113 -1.054 Td (respiratoire )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf -0.004 Tc 8.2 0 0 8.2 351.742 389.0472 Tm (\(VT{ft\) )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.3173 0 0 8.2 379.59 389.05 Tm (et )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0003 Tc 8.2 0 0 8.2 388.26 389.05 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0135 Tc 8.2 0 0 8.2 397.3538 389.05 Tm (fraction )Tj 0.2 0.2 0.188 rg 0.0243 Tc 3.515 0 Td (inspiratoire )Tj 0.259 0.263 0.247 rg 0.05 Tc 8.2998 0 0 8.2 467.92 389.05 Tm (du )Tj -0.0093 Tc 8.2 0 0 8.2 479.44 389.05 Tm (cycle )Tj 0.0229 Tc 2.35 0 Td (respiratoire )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0064 Tc 8.2 0 0 8.2 310.4626 379.9316 Tm (\(TI/T,.,\) )Tj EMC ET BT /T1_0 1 Tf 0.0283 Tc 8.2 0 0 8.2 339.2692 379.9316 Tm (etaient )Tj 0.0316 Tc 3.045 0 Td (obtenus )Tj 0.05 Tc 8.4273 0 0 8.2 393.13 379.93 Tm (par )Tj 0.0074 Tc 8.2 0 0 8.2 406 379.93 Tm (calcul )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 12.4 0 0 12.4 428.03 379.93 Tm (a )Tj EMC ET BT /T1_0 1 Tf 0.0492 Tc 8.2 0 0 8.2 433.93 379.93 Tm (partir )Tj 0.0117 Tc 2.623 0 Td (des )Tj 0.0215 Tc 1.58 0 Td (donnees )Tj 0.0098 Tc 3.628 0 Td (enregistrees )Tj 0.0163 Tc -22.891 -1.112 Td (sur )Tj 0.0289 Tc 1.937 0 Td (ordinateur. )Tj 0.015 Tc 5.33 0 Td (En )Tj 0.0186 Tc 1.82 0 Td (reponse )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 12.4 0 0 12.4 416.51 370.81 Tm (a )Tj EMC ET BT /T1_0 1 Tf 0.0221 Tc 8.2 0 0 8.2 425.97 370.81 Tm (!'inhalation )Tj 0 Tc 5.409 0 Td (d)Tj 0.4 0.404 0.392 rg 0.584 0 Td (')Tj 0.259 0.263 0.247 rg 0.0127 Tc 0.302 0 Td (histamine )Tj 0.05 Tc 8.3916 0 0 8.2 515.44 370.81 Tm (ou )Tj 0.0026 Tc 8.2 0 0 8.2 529.84 370.81 Tm (de )Tj 0.2 0.2 0.188 rg -0.0163 Tc -26.802 -1.112 Td (methy1chol)Tj 0.09 0.094 0.078 rg 0 Tc 4.618 0 Td (i)Tj 0.259 0.263 0.247 rg -0.0095 Tc 0.3 0 Td (ne, )Tj 0.0019 Tc 1.748 0 Td (chez )Tj -0.02 Tc 2.401 0 Td (les )Tj 0.0071 Tc 1.637 0 Td (fumeurs )Tj 0.0164 Tc 3.865 0 Td (comme )Tj 0.0214 Tc 3.571 0 Td (chez )Tj -0.02 Tc 2.401 0 Td (les )Tj 0.0188 Tc 1.646 0 Td (non-fumeurs, )Tj 0.0355 Tc -22.194 -1.054 Td (aucun )Tj 0.0189 Tc 2.81 0 Td (changement )Tj 0.05 Tc 8.2927 0 0 8.2 375.76 353.05 Tm (de )Tj 0.042 Tc 8.2 0 0 8.2 385.9 353.05 Tm (mode )Tj 0.2 0.2 0.188 rg 0.0129 Tc 2.576 0 Td (ventilatoire )Tj 0.259 0.263 0.247 rg -0.0031 Tc 4.977 0 Td (ne )Tj 0.0208 Tc 1.22 0 Td (fut )Tj -0.0001 Tc 1.465 0 Td (observe. )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf 0.05 Tc 8.4707 0 0 8.2 500.12 353.05 Tm (Par )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0335 Tc 8.2 0 0 8.2 513.52 353.05 Tm (contre, )Tj 0.0133 Tc -24.821 -1.112 Td (en )Tj 0.0089 Tc 1.298 0 Td (reponse )Tj 0.2 0.2 0.188 rg 0.0157 Tc 3.445 0 Td (aux )Tj 0.259 0.263 0.247 rg 0.0187 Tc 1.756 0 Td (deux )Tj 0.0127 Tc 2.278 0 Td (substances, )Tj 0.0359 Tc 4.933 0 Td (pour )Tj -0.0043 Tc 2.282 0 Td (un )Tj 0.0242 Tc 1.348 0 Td (bronchospasme )Tj 0.2 0.2 0.188 rg 0.0026 Tc 6.721 0 Td (de )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0077 Tc 8.2 0 0 8.2 517.4314 343.9316 Tm (meme )Tj EMC ET BT /T1_0 1 Tf 0.0014 Tc 8.2 0 0 8.2 310.5044 334.8132 Tm (intensite, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.8117 0 0 8.2 342.7 334.81 Tm (VT )Tj EMC ET BT /T1_0 1 Tf 0.0224 Tc 8.2 0 0 8.2 354.15 334.81 Tm (et, )Tj 0.05 Tc 8.4273 0 0 8.2 364.81 334.81 Tm (par )Tj 0.0192 Tc 8.2 0 0 8.2 378.16 334.81 Tm (consequent, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.0677 0 0 8.5 420.95 334.81 Tm (VE )Tj EMC ET BT /T1_0 1 Tf 0.0228 Tc 8.2 0 0 8.2 431.92 334.81 Tm (augmentaient )Tj 0.0036 Tc 5.907 0 Td (significativement )Tj 0.0022 Tc -20.777 -1.055 Td (et )Tj 0.0362 Tc 1.055 0 Td (dans )Tj ET BT /Suspect <>BDC 0.341 0.345 0.333 rg /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8.2 337.39 326.16 Tm (Ia )Tj EMC /Suspect <>BDC 0.259 0.263 0.247 rg 0.0077 Tc 8.2 0 0 8.2 346.06 326.16 Tm (meme )Tj EMC ET BT /T1_0 1 Tf 0.0394 Tc 8.2 0 0 8.2 368.651 326.16 Tm (proportion )Tj 0.0214 Tc 4.848 0 Td (chez )Tj -0.035 Tc 7.9707 0 0 8.2 426.17 326.16 Tm (les )Tj 0.0187 Tc 8.2 0 0 8.2 437.2 326.16 Tm (deux )Tj 0.0213 Tc 2.343 0 Td (groupes )Tj 0.2 0.2 0.188 rg 0.0017 Tc 3.635 0 Td (testes)Tj 0.341 0.345 0.333 rg 0 Tc 2.265 0 Td (. )Tj 0.259 0.263 0.247 rg 0.0256 Tc 0.538 0 Td (Chez )Tj -0.02 Tc 2.401 0 Td (les )Tj 0.0188 Tc -26.685 -1.111 Td (non-fumeurs, )Tj 0.05 Tc 8.3916 0 0 8.2 357.52 317.05 Tm (on )Tj 0.0164 Tc 8.2 0 0 8.2 368.56 317.05 Tm (observait, )Tj 0.0133 Tc 4.272 0 Td (en )Tj 0.0235 Tc 1.23 0 Td (outre, )Tj 0.0105 Tc 2.702 0 Td (une )Tj 0.2 0.2 0.188 rg 0.0159 Tc 1.755 0 Td (relation )Tj 0.259 0.263 0.247 rg 0.0005 Tc 3.382 0 Td (significative )Tj 0.0328 Tc 5.155 0 Td (entre )Tj -0.035 Tc 7.9307 0 0 8.2 310.03 307.93 Tm (Ia )Tj 0.035 Tc 8.2 0 0 8.2 319.6 307.93 Tm (chute )Tj 0.05 Tc 8.2998 0 0 8.2 342.16 307.93 Tm (du )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0326 Tc 8.2 0 0 8.2 354.7 307.93 Tm (VEMS )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0022 Tc 8.2 0 0 8.2 381.9896 307.93 Tm (et )Tj 0.2 0.2 0.188 rg 0.0248 Tc 1.207 0 Td (!'augmentation )Tj 0.259 0.263 0.247 rg 0.05 Tc 8.2927 0 0 8.2 446.8 307.93 Tm (de )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf -0.035 Tc 7.0677 0 0 8 458.87 307.93 Tm (VE )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.05 Tc 8.3173 0 0 8.2 471.75 307.93 Tm (et )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf -0.006 Tc 8.2 0 0 8.2 481.9 307.93 Tm (VT{fl. )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0256 Tc 8.2 0 0 8.2 507.7628 307.93 Tm (Chez )Tj 0.2 0.2 0.188 rg -0.02 Tc 2.577 0 Td (les )Tj 0.259 0.263 0.247 rg 0.0038 Tc -26.695 -1.055 Td (fumeurs, )Tj 0.2 0.2 0.188 rg 0.0105 Tc 4.109 0 Td (une )Tj 0.259 0.263 0.247 rg -0.0043 Tc 1.929 0 Td (telle )Tj 0.0201 Tc 2.159 0 Td (correlation )Tj 0.0303 Tc 5.043 0 Td (n'etait )Tj 0.2 0.2 0.188 rg 0.0117 Tc 3.046 0 Td (pas )Tj 0.259 0.263 0.247 rg 0.0075 Tc 1.873 0 Td (presente. )Tj -0.0065 Tc 4.145 0 Td (Ces )Tj 0.0157 Tc 1.94 0 Td (resultats )Tj 0.0151 Tc -24.306 -1.112 Td (suggerent )Tj 0.0446 Tc 4.454 0 Td (que )Tj 0.0178 Tc 1.967 0 Td (!'histamine )Tj 0.0022 Tc 4.998 0 Td (et )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8.2 413.23 290.16 Tm (Ia )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.012 Tc 8.2 0 0 8.2 422.86 290.16 Tm (methylcholine )Tj 0.0449 Tc 6.315 0 Td (ont )Tj -0.0023 Tc 1.816 0 Td (le )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0119 Tc 8.2 0 0 8.2 499.1856 290.16 Tm (meme )Tj EMC ET BT /T1_0 1 Tf 0.0013 Tc 8.2 0 0 8.2 522.6376 290.16 Tm (effet )Tj 0.341 0.345 0.333 rg 0.05 Tc 8.3388 0 0 8.2 309.48 281.05 Tm (st)Tj 0.2 0.2 0.188 rg 0.0212 Tc 8.2 0 0 8.2 315.77 281.05 Tm (imulateur )Tj 0.259 0.263 0.247 rg 0.0455 Tc 4.209 0 Td (sur )Tj -0.02 Tc 1.587 0 Td (les )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0058 Tc 8.2 0 0 8.2 374.4 281.05 Tm (recepteurs )Tj EMC /Suspect <>BDC 0.259 0.263 0.247 rg 0 Tc 12.4 0 0 12.4 410.75 281.05 Tm (a )Tj EMC ET BT /T1_0 1 Tf 0.025 Tc 8.2 0 0 8.2 416.85 281.05 Tm (!'irritation )Tj 0.0117 Tc 4.53 0 Td (des )Tj 0.001 Tc 1.588 0 Td (voies )Tj 0.0032 Tc 2.393 0 Td (aeriennes. )Tj 0.0024 Tc 4.332 0 Td (Ceci )Tj 0.2 0.2 0.188 rg 0.0203 Tc -25.93 -1.112 Td (indique )Tj 0.259 0.263 0.247 rg 0.0446 Tc 3.335 0 Td (que )Tj -0.0031 Tc 1.751 0 Td (seules )Tj 0.2 0.2 0.188 rg -0.02 Tc 2.64 0 Td (les )Tj 0.259 0.263 0.247 rg -0.0059 Tc 1.287 0 Td (afferences )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0001 Tc 8.2 0 0 8.2 418.9246 271.9316 Tm (stimulees )Tj EMC ET BT /T1_0 1 Tf 0.0219 Tc 8.2 0 0 8.2 451.618 271.9316 Tm (indirectement )Tj 0.05 Tc 8.4273 0 0 8.2 500.65 271.93 Tm (par )Tj -0.0023 Tc 8.2 0 0 8.2 513.53 271.93 Tm (le )Tj 0.0094 Tc 1.005 0 Td (bia)Tj 0 g 0 Tc 1.207 0 Td (.)Tj 0.259 0.263 0.247 rg -0.035 Tc 7.8068 0 0 8.2 532.26 271.93 Tm (is )Tj 0.2 0.2 0.188 rg 0.05 Tc 8.2927 0 0 8.2 309.52 263.28 Tm (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8.2 323.95 263.28 Tm (Ia )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0269 Tc 8.2 0 0 8.2 336.4 263.28 Tm (contraction )Tj 0.05 Tc 8.2927 0 0 8.2 382 263.28 Tm (de )Tj 0.2 0.2 0.188 rg -0.0003 Tc 8.2 0 0 8.2 396.42 263.28 Tm (Ia )Tj 0.259 0.263 0.247 rg 0.0215 Tc 1.527 0 Td (musculature )Tj -0.0155 Tc 5.848 0 Td (lisse )Tj 0.0218 Tc 2.585 0 Td (bronchique )Tj 0.0384 Tc 5.428 0 Td (sont )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0026 Tc 8.2 0 0 8.2 309.5328 254.1616 Tm (impliquees )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0362 Tc 8.2 0 0 8.2 349.3602 254.1616 Tm (dans )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8.2 369.07 254.16 Tm (Ia )Tj EMC ET BT 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0089 Tc 8.2 0 0 8.2 379.19 254.16 Tm (reponse )Tj 0.05 Tc 8.3101 0 0 8.2 408.88 254.16 Tm (au )Tj 0.0193 Tc 8.2 0 0 8.2 421.45 254.16 Tm (bronchospasme )Tj 0.0078 Tc 6.896 0 Td (aigu, )Tj 0.0153 Tc 2.459 0 Td (que )Tj 0.0121 Tc 1.932 0 Td (ce )Tj 0.0347 Tc 1.283 0 Td (soit )Tj 0.05 Tc 8.2675 0 0 8.2 309.61 245.05 Tm (pour )Tj 0.2 0.2 0.188 rg 0.0336 Tc 8.2 0 0 8.2 330.93 245.05 Tm (!'adaptation )Tj 0.259 0.263 0.247 rg 0.05 Tc 8.2927 0 0 8.2 377.2 245.05 Tm (de )Tj -0.035 Tc 7.9307 0 0 8.2 390.67 245.05 Tm (Ia )Tj 0.029 Tc 8.2 0 0 8.2 401.68 245.05 Tm (commande )Tj 0.0155 Tc 5.21 0 Td (ou )Tj 0.2 0.2 0.188 rg 0.05 Tc 8.2998 0 0 8.2 457.84 245.05 Tm (du )Tj 0.259 0.263 0.247 rg 0.0225 Tc 8.2 0 0 8.2 472.3 245.05 Tm (mode )Tj 0.0105 Tc 2.927 0 Td (ventilatoire. )Tj 0.2 0.2 0.188 rg 0.0199 Tc -22.773 -1.054 Td (L'absence )Tj 0.05 Tc 8.2927 0 0 8.2 346 236.41 Tm (de )Tj 0.259 0.263 0.247 rg 0.0201 Tc 8.2 0 0 8.2 357.04 236.41 Tm (correlation )Tj 0.0181 Tc 4.974 0 Td (entre )Tj 0.0156 Tc 2.461 0 Td (l'intensite )Tj 0.05 Tc 8.2998 0 0 8.2 453.52 236.41 Tm (du )Tj 0.0193 Tc 8.2 0 0 8.2 466.09 236.41 Tm (bronchospasme )Tj 0.0022 Tc 6.837 0 Td (et )Tj -0.035 Tc 7.3018 0 0 8.2 531.32 236.41 Tm (Je )Tj 0.0254 Tc 8.2 0 0 8.2 309.04 227.29 Tm (changement )Tj 0.0026 Tc 5.385 0 Td (de )Tj 0.029 Tc 1.288 0 Td (commande )Tj 0.0129 Tc 4.924 0 Td (ventilatoire )Tj 0.0019 Tc 5.027 0 Td (chez )Tj -0.02 Tc 2.167 0 Td (les )Tj 0.2 0.2 0.188 rg 0.0168 Tc 1.402 0 Td (fumeurs )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf 0.0306 Tc 8.2 0 0 8.2 504.8724 227.29 Tm (asympto\255)Tj EMC ET BT /T1_0 1 Tf 0.0123 Tc 8.2 0 0 8.2 309.573 218.6472 Tm (matiques )Tj 0.0033 Tc 4.437 0 Td (suggere )Tj 0.2 0.2 0.188 rg 0.0446 Tc 3.868 0 Td (que )Tj ET BT /Suspect <>BDC 0.259 0.263 0.247 rg /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8.2 396.43 218.65 Tm (Ia )Tj EMC /Suspect <>BDC 0.0005 Tc 8.2 0 0 8.2 408.39 218.65 Tm (fumee )Tj EMC ET BT /T1_0 1 Tf 0.017 Tc 8.2 0 0 8.2 435.286 218.65 Tm (induit )Tj 0.2 0.2 0.188 rg 0.0105 Tc 3.228 0 Td (une )Tj 0.259 0.263 0.247 rg 0.0207 Tc 2.156 0 Td (dysfonction )Tj 0.0117 Tc 5.678 0 Td (des )Tj 0.0123 Tc -26.391 -1.113 Td (recepteurs )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 12.4 0 0 12.4 347.87 209.52 Tm (a )Tj EMC ET BT /T1_0 1 Tf 0.025 Tc 8.2 0 0 8.2 355.89 209.52 Tm (!'irritation )Tj 0.0105 Tc 4.765 0 Td (qui )Tj 0.0344 Tc 1.826 0 Td (pourrait )Tj ET BT /Suspect <>BDC 0.2 0.2 0.188 rg /T1_0 1 Tf 0.0119 Tc 8.2 0 0 8.2 442.0966 209.52 Tm (preceder )Tj EMC ET BT /T1_0 1 Tf 0.0276 Tc 8.2 0 0 8.2 474.9376 209.52 Tm (!'apparition )Tj 0.259 0.263 0.247 rg 0.0026 Tc 5.35 0 Td (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8.2 530.83 209.52 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0204 Tc 8.2 0 0 8.2 309.1 200.41 Tm (maladie )Tj 0.0147 Tc 3.622 0 Td (obstructive )Tj 0.0298 Tc 4.917 0 Td (chronique )Tj 0.05 Tc 8.3916 0 0 8.2 416.08 200.41 Tm (ou )Tj 0.0026 Tc 8.2 0 0 8.2 427.6 200.41 Tm (de )Tj -0.035 Tc 7.9307 0 0 8.2 438.19 200.41 Tm (Ia )Tj 0.0198 Tc 8.2 0 0 8.2 447.37 200.41 Tm (bronchite )Tj 0.0248 Tc 4.204 0 Td (chronique. )Tj ET endstream endobj 102 0 obj <>stream Hd͊zy8 >sRhF^#y QG#Oç==o/ϧ;c_mӷKv|~_oo~y>}~W=|z>{O݇q~?>Ï?o+~ߒ~;%zΏx߽w;>lp?(O?{wٸ^ 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